presentspresents

The Canine Thyroid EpidemicThe Canine Thyroid Epidemic

with Dr Jean Dodds, D.V.M.with Dr Jean Dodds, D.V.M.

presentspresents

The Canine Thyroid EpidemicThe Canine Thyroid Epidemic

with Dr Jean Dodds, D.V.M.with Dr Jean Dodds, D.V.M.

In support of Hemopet

Since 1994Since 1994Since 1994Since 1994

Dr Jean Dodds,Dr Jean Dodds,D.V.M.D.V.M.

WELCOMEWELCOME

4

www.hemopet.orgwww.hemopet.org

Welcome to theWelcome to the

Canine Thyroid EpidemicCanine Thyroid Epidemic

with Dr Jean Dodds, D.V.M.with Dr Jean Dodds, D.V.M.

Welcome to theWelcome to the

Canine Thyroid EpidemicCanine Thyroid Epidemic

with Dr Jean Dodds, D.V.M.with Dr Jean Dodds, D.V.M.

In support of Hemopet

7

by

W. Jean Dodds, DVM

Hemopet/Hemolife

8

Puppies have higher basal thyroid levels than adults

Geriatrics have lower basal thyroid levels than adults

Large/giant breeds have lower basal thyroid levels

Sight hounds have much lower basal thyroid levels

9

Dividing the daily dose q 12 hrs avoids “peak and valley” effect of once daily dosing

Achieves better steady state over 24 hrs; half-life =12-16 hrs

Dosing should be given directly by mouth rather than in food bowl

Thyroxine binds to calcium and soy; should be given apart from meals (1 hr before or 3 hrs after)

10

Complete thyroid antibody profile preferred

cTSH poorly predictive (~ 70%) compared to humans

Basal levels affected (up to 25%) by certain drugs (steroids, Pb, sulfonamides, excess iodine)

Basal levels lowered by estrogen; raised by progesterone [sex hormonal cycle effects]

Rabies vaccine in prior 45 days can raise TgAA by ~ 25 %

11

Complete thyroid antibody profile required

Test intact bitches during anestrus

Need T3AA, T4AA, TgAA; not just freeT4, TSH, TgAA

OFA Thyroid Registry is limited panel

Some cases (~8%) are T3AA and/or T4AA +, but TGAA -

12

Treat all cases + for T3AA and/or T4AA, or TgAA

Don’t wait until dog gets ill or has aberrant behavior

If only low-grade TgAA + , retest profile in 2-4 mos

Treat with thyroxine BID; retest profile in 2-4 mos

Always monitor with thyroid antibody profile

13

• Screen relatives annually from puberty

• Consider for breeding, if negative, after age three

• Heritable trait, regardless of clinical status

14

1. Classical clinical hypothyroidism & low thyroid values occur after =/> 70% thyroid tissue destroyed

2. Other clinical / behavioral changes (especially aggression) seen during early phase

3. T4 alone gives misleading results; over-diagnose hypothyroidism with non-thyroidal illness or certain drugs; under-diagnose hyperthyroidism in cats or from thyroxine overdosage; inaccurately assesses thyroxine therapy; and fails to detect autoimmune thyroiditis

15

4. Even T4 plus freeT4 and TSH = inadequate, if thyroiditis present

5. Age-and breed-specific norms essential for accurate diagnosis; reference lab ranges not based on age and breed type

6. Sight hounds all have lower basal thyroid activity than other breeds

7. Thyroxine binds to calcium & soy; must be given apart from meals; BID therapy preferred

16

8. Dispensing thyroxine by human pharmacist often under-dosed [animal doses 10 x higher]

9. Stopping thyroxine to retest basal capacity needs 6 weeks or more

10. Thyroid Support or Thytrophin inadequate alone to fully correct true hypothyroidism or thyroiditis

17

cTSH poorly predictable for 1o

hypothyroidism in dogs [~ 70%] vs. people [95%]

Dog has second regulatory pathway via growth hormone

False negatives and false positives (i.e. discordant) occur in ~ 30% of cases

18

Blood samples should be drawn 4-6 hrs post-pill for BID Rx.

Blood samples drawn 8-10 hrs post-pill for SID Rx (horses)

Minimum testing needed is T4 and freeT4

Thyroid antibody profile preferred; a must for thyroiditis cases

19

Because the body can increase thyroxine turnover rate ~ 50 % and excrete it faster to avoid thyrotoxicosis

20

Principal reason for pet euthanasia is undesirable behavior

Association between behavioral / psychologic changes and thyroid dysfunction long recognized in humans

66% of people with ADHD found to be hypothyroid; thyroxine largely curative

21

Parallel findings in dogs with thyroiditis/hypothyroidism; & cats with hyperthyroidism

Typical clinical signs: unprovoked aggression, sudden onset seizure disorder, disorientation, moodiness, erratic temperament, hyperactivity, hypoattentiveness, depression, fearfulness , phobias, anxiety, passivity, submissiveness, compulsiveness, and irritability

22

Individuals deficient in selenium show clinical signs of hypothyroidism because tissue levels of thyroid hormones are depleted, while blood thyroid levels rise

Diagnosis could be overlooked on the basis that blood levels of thyroid hormones appear normal

23

Iodine excess causes alterations in thyroid activity, blocking both its characteristic functions and cell proliferation

Feeding excessive amounts of iodine in foods and supplements (kelp, seaweed) reduces thyroid function

Could contribute to the rising prevalence of hypothyroidism in young dogs

Iodine increases auto-antigenic potency of thyroglobulin leading to induction of autoimmune thyroiditis

24

Multiple endocrine glands become involved in a systemic immune-mediated process

Patients have underlying autoimmune thyroid disease and concurrent Addison’s disease, diabetes, reproductive failure, skin disease, alopecia, and IBD

Most commonly associated non-endocrinologic autoimmune disorders are: AIHA, ITP, chronic active hepatitis, and immune-complex glomerulonephritis (SLE)

 

25

 

Canine autoimmune thyroid disease similar to human Hashimoto’s Disease

Affected humans & dogs have MHC gene profile which predispose to thyroiditis

Unique DLA-DQA1*00101 genetic determinant of DLA class II haplotype found in Doberman Pinscher, English Setter and Rhodesian Ridgeback; doubles risk of hypothyroidism; 11 more breeds now under study

Second genotype of the CTLA locus found in Boxer, Shih Tzu, Yorkshire Terrier, Irish Water Spaniel, and Siberian Husky affected with thyroiditis

Holds promise for a genetic marker test to identify affected breeding stock and allow for selective breeding to reduce disease incidence

26

Soon to be released…

27

28

Thyroid 5 TM is composed of T4, Free T4, T3, Free T3 and TGAA

 The TGAA (thyroglobulin autoantibody) test is included for genetic screening of breeds and cross-breeds at risk for heritable autoimmune thyroiditis. The confirmatory TGAA method is preferred because it removes any non-specific binding that could falsely elevate the result

 

NEW HEMOLIFE THYROID 5 TM PANEL

29

Also, since ~ 8% of thyroiditis cases have high circulating T3AA and/or T4AA but normal TGAA, T3AA and T4AA is measured IF warranted from initial results or when either of these tests were previously high

As relatively few cases have high T3AA and/or T4AA, it will be more cost effective for clients to have the new Thyroid 5 TM profile run rather than our current D8T + TGAA combination

Novel, ‘green’ non-RIA technology never used before in veterinary medicine (patented)

NEW HEMOLIFE THYROID 5 TM PANEL

30

HEMOPET / HEMOLIFE

11561 Salinaz Avenue Garden Grove, California 92843

Phone 714 -891-2022 Fax 714 -891-2123

www.hemopet.org ; hemopet@hotmail.com

THYROID GOLD ™ REGISTRATION CERTIFICATE

This is to certify that __________________________________ , Reg. # ____________ __, owned by _________________________________________________________________, has successfully earned the THYROID GOLD ™ Registration Certificate . Testing was peformed on, Date _______________; Hemolife Acc. # __________.

Certificate Number : _________ W. J ean Dodds, DVM

President

31

To get your dog’s thyroid accurately tested…

Get your downloadable form at

http://www.wisdomfordoglovers/get-the-wisdom

If you have questions…

Susan at info@wisdomfordogs.com

Dr. Jean at hemopet@hotmail.com

Available now at www.WisdomForDogLovers.comAvailable now at www.WisdomForDogLovers.com

SUPPLEMENTS…

Are they Helping, Harming, or

Just Wasting MY Money!?!

SUPPLEMENTS…

Are they Helping, Harming, or

Just Wasting MY Money!?!

presentspresentspresentspresents

Monday, July 18, 2011 at 6pm PSTMonday, July 18, 2011 at 6pm PST

with Dr Jean Doddswith Dr Jean Dodds

Monday, July 18, 2011 at 6pm PSTMonday, July 18, 2011 at 6pm PST

with Dr Jean Doddswith Dr Jean Dodds

In support of HemopetIn support of Hemopet

PresentsPresents

Vaccination protocolsVaccination protocolsA Secret Many Vets Don’t Want You to Know!A Secret Many Vets Don’t Want You to Know!

PresentsPresents

Vaccination protocolsVaccination protocolsA Secret Many Vets Don’t Want You to Know!A Secret Many Vets Don’t Want You to Know!

In support of HemopetIn support of Hemopet

Monday, May 9, 2011 at 6pm PSTMonday, May 9, 2011 at 6pm PST

with Dr Jean Doddswith Dr Jean Dodds

Monday, May 9, 2011 at 6pm PSTMonday, May 9, 2011 at 6pm PST

with Dr Jean Doddswith Dr Jean Dodds

website:website: www.wisdomfordoglovers.comwww.wisdomfordoglovers.com

facebook:facebook: http://www.facebook.com/wisdomfordoglovershttp://www.facebook.com/wisdomfordoglovers

Delivering Leading Edge Science and Wisdom for Dog OwnersDelivering Leading Edge Science and Wisdom for Dog Owners

37

Spread the wordSpread the word

Thanks a heap for paying it forward…Thanks a heap for paying it forward…tell your fur-friends about Wisdom for Dog Loverstell your fur-friends about Wisdom for Dog Lovers

38

For the love of dogs…For the love of dogs…

www.wisdomfordoglovers.com