Presented By William Tap at 2014 ASCO Annual Meeting
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Transcript of Presented By William Tap at 2014 ASCO Annual Meeting
<br /> A Pilot Study of PLX3397, a Selective Colony-Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitor, in Pigmented Villonodular Synovitis (PVNS)
Presented By William Tap at 2014 ASCO Annual Meeting
Pigmented Villonodular Synovitis (PVNS)<br />Tenosynovial Giant Cell Tumor (TGCT)
Presented By William Tap at 2014 ASCO Annual Meeting
Pigmented Villonodular Synovitis (PVNS)
Presented By William Tap at 2014 ASCO Annual Meeting
Slide 4
Presented By William Tap at 2014 ASCO Annual Meeting
Can we help patients (PVNS) <br />with a highly targeted therapy (PLX3397)<br />that blocks the CSF1R pathway <br />in this clonal neoplastic process frequently<br />initiated by a single genetic event?
Presented By William Tap at 2014 ASCO Annual Meeting
Study Goals
Presented By William Tap at 2014 ASCO Annual Meeting
Study Design
Presented By William Tap at 2014 ASCO Annual Meeting
Efficacy Assessments
Presented By William Tap at 2014 ASCO Annual Meeting
Tumor Volume Score (TVS)
Presented By William Tap at 2014 ASCO Annual Meeting
Patient Disposition
Presented By William Tap at 2014 ASCO Annual Meeting
Patient Characteristics: Safety Population (n=23)
Presented By William Tap at 2014 ASCO Annual Meeting
Safety: PVNS Expansion Cohort AEs<br />n = 23 Safety Population
Presented By William Tap at 2014 ASCO Annual Meeting
Treatment-Related AEs ≥ Grade 3
Presented By William Tap at 2014 ASCO Annual Meeting
Duration of Treatment (DOT), April 2014 data cutoff:<br />Median 256 days (range 21-585 days)
Presented By William Tap at 2014 ASCO Annual Meeting
14 patients evaluable with TVS
Presented By William Tap at 2014 ASCO Annual Meeting
Slide 16
Presented By William Tap at 2014 ASCO Annual Meeting
Slide 17
Presented By William Tap at 2014 ASCO Annual Meeting
Slide 18
Presented By William Tap at 2014 ASCO Annual Meeting
Slide 19
Presented By William Tap at 2014 ASCO Annual Meeting
Slide 20
Presented By William Tap at 2014 ASCO Annual Meeting
Slide 21
Presented By William Tap at 2014 ASCO Annual Meeting
Conclusions
Presented By William Tap at 2014 ASCO Annual Meeting
Thank You
Presented By William Tap at 2014 ASCO Annual Meeting