Presentazione di PowerPoint - Dipartimenti€¦ · School of Natural Sciences, University of...
Transcript of Presentazione di PowerPoint - Dipartimenti€¦ · School of Natural Sciences, University of...
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100mV
4mV
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LTP
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1997 Sjöström and Gerstner (2010)
STDP LTP
LTD
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Donald Hebb, 1949
La connessione tra due neuroni è rinforzata se i due neuroni sono attivi
simultaneamente (fire together, wire together)
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Kauer and Malenka, 2007
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Palmer et al., 2012 Larkum et al., 2009
“Enigma supremo”
D. Hubel
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Model of STDP induction in apical dendrites of layer 5 pyramidal neurons.
Johannes J. Letzkus et al. J. Neurosci. 2006;26:10420-
10429
©2006 by Society for Neuroscience
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Bottom-up
Top-down
Contextual Amplification
Apical Amplification
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V1 Higher
bottom-up
top-down
LGN
S1 M1
bottom-up
top-down
Engel et al., 2001
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V1 Higher
bottom-up
top-down
LGN
MC
Som
VIP top-down
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Cerminara et al., 2015
Marr-Albus-Ito Error
Context
LTD @ PF-PC decreased AMPA-R
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Classen et al., 1998
30 minuti di “esercizio” possono modificare la mappa corticale di M1
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Fire together, wire together
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Is it really better to have your brain lesion early? A revision of the “Kennard principle”
Schneider, 1979
? La plasticità è sempre
buona?
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Giannetti et al., 2000
Plasticità (maladattativa)
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Granato A et al. J. Neurosci. 2012;32:1377-1382
©2012 by Society for Neuroscience
Intellectual disability Ca++
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