Presentation1 Chitosan Final
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Transcript of Presentation1 Chitosan Final
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7/21/2019 Presentation1 Chitosan Final
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By :Hermawan Judawisastra, J.B.A Nordin, B. Sunendar
Material Science and Engineering Research GroupFaculty of Mechanical and Aerospace Engineering - ITB
Bandung, I !" ESIA
#
1 st International Conference on Materials Engineering(ICME) and 3 rd AUN/SEED-Net Regional Conference on
Materials (RCM) 2-3 e!r"ar# 2$11% &og#a'arta%Indonesia
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Increase of de$and for hu$anprosthetic de%ices & 'ody transplant
(ure titaniu$ and Ti)*Al)+ idelyused .e/cellent 'ioco$pati'ility, lo 0oung1s $odulus, and high toughness2
$ay release har$ful $etal particles . and Al ions2
3ydro/yapatite .4a 5 .(" +26 ."32 coating.sta'ility, 'ioco$pati'ility2
%ery 'rittle and easy to 7a8e out duringi$plantation
6# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
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43IT"SA :
; A'undant in nature; Bioacti%e (roperties
.anti'acterial, 'iodegrada'le, non-to/ic, andthe a'ility to attract and pro$ote 'one cellgro th and organi
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+
In%estigate e>ects of %arying 4hitosanM on:
; Bioactivity of Chitosan Membranes (L Mw and HMw!
; Adhesiveness of Chitosan Coatin"s on #i $A% &'
; Bioactivity of Chitosans A atite Coatin" on #i$A% &'
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
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5# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
A?!RI43@
4hitosan ?o Mchitosan
3igh M 4hitosan
!eacytelation
5- 5C D 5C
iscosity 6 ) 6 cps -6 cp
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*
Bioactivity of Chitosan Membrane
Adhesiveness of Chitosan Coatin"
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
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Bioactivity of Chitosan A atite Coatin"
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
sa$ple of Ti-*Al-+ coated ith 3igh M chitosan .Ti-3-4s2
; Ti -3-4s -3-A; Ti -3-4s -?-A
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a%enu$'er
.c$-#2
Assign$ent
day # day days
a%e
nu$'er.c$-#2
Intensity
a%enu$'er.c$-#2
Intensity
a%enu$'er.c$-#2
Intensity
6 6 36, 4363-4s 6 # = = 6 # = *= 95 6 # = #+=6?-4s 6 # = =##+ 6 += =## 6 # = +=
#9 94-"-4H 4-
439
3-4s #9 *= #*= #9 = #5= 9 #9 = 6 = #?-4s #96*= 6+=65 #9 = =9+ #9 = 6 =*#
Crysta%%inity )nde*H Cs + $- $$
L Cs & // 01+
FTIR Spectroscopy results
; The crystallinity inde/ .4rI2 of the sa$ples ere calculated fro$ the ratio of a'sor'a at #9 6 and 6 6 c$-# .special pea8s for chitosan2=
; Sharp 4rI increase of ?-4s indicates its higher co$pati'ility in o8u'o1s solution co$to 3-4s
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
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FTIR Spectroscopy results
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
3-4s 'efore and after i$$ersion ?-4s 'efore and after i$$ersion
; For 'ioacti%e product, appearance of phosphate group pea8s=; After i$$ersion: (ea8s of ?-4s are shaper after co$pared to 3-4s pea8s=; The high increased of ?-4s 4rI: the for$ation of poor crystalline phosphate=
?-4s is $ore 'ioacti%e co$pared to 3-4s
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SEM results
#
Before i$$ersion After days i$$ersion
3-M 4s
?-M4s
More crystalline
More 4a4" 1 granules# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
?-4s is $ore 'ioacti%e co$pared to 3-4s=
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SEM e/a$ination of =68gf load Micro%ic8ers indentatio
Ti-3-4s.3igh M 2
Ti-?-4s.?o M 2
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
Ti-3-4s is 'etter for Ti-*Al-+ coating than Ti-?-4s=
; locali
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#6
Apatite , Ti"6 Apatite , Ti"6
3igh M ?o M
JR! E/a$ination
; E/posure of Ti"6 due to 4s-Apatite 7a8ing ; Increase of apatite indication of cellsa'sorption and osteo'last generation
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
Ti -3-4s -?-A Ti -3-4s -3-A
Ti -3-4s -L-A is $ore 'io- acti%e Ti -3-4s -H -A
Hi"h Mw
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SEM e/a$ination .'efore i$$ersion2
Finer Apatite $olecules due toeasier interaction ith "3- and 36
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
3igh M ?o M Ti -3-4s -?-A Ti -3-4s -3-A
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SEM e/a$ination .after i$$ersion23igh M ?o M Reference
; 3-4s- H A e/hi'its ho$ogeneously gro n apatite agglo$eration=; 3-4s- L A sho s e%idence of ell for$ed apatite gro th, si$ilar to referen
and $ore li8ely to generate osteo'last=
# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
Ti -3-4s -?-A Ti -3-4s -3-A
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?o $olecular eight 4hitosan .?-4s2 is $ore'ioacti%e than high $olecular eight 4hitosan.3-4s2=
3igh M chitosan coating on Ti-*Al-+ .Ti-3-4s2is $ore adhesi%e co$pare to lo M chitosanon Ti-*Al-+ .Ti-?-4s2 as Ti-3-4s sho ed $oreductile fracture $ode=
4oated Ti-3-4s ith lo M chitosan andapatite .Ti-3-4s-?-A2 is $ore 'ioacti%e co$pareto Ti-3-4s ith high M and apatite .Ti-3-4s-3-A2= This type of coating layer also successfullyeli$inates Al and release=
#*# st I4ME & 9 rd R4M ) 0ogya8arta, Fe'ruary 6nd ) 9rd , 6 ##
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17/17## st I4ME & 9 rd R4M ) 0 g 8 t F ' 6 d ) 9 d 6 ##