Powering Implantable Medical Devices - Berkeley Nano - Medical... · 3 Highlights fFounded by...
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Powering Implantable Medical Devices Dr. Sujeet Kumar MIT•Stanford•UC Berkeley Nanotechnology Forum October 6, 2005
Transcript of Powering Implantable Medical Devices - Berkeley Nano - Medical... · 3 Highlights fFounded by...
Powering Implantable
Medical Devices
Dr. Sujeet Kumar
MIT•Stanford•UC Berkeley Nanotechnology ForumOctober 6, 2005
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About Us
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Highlights
Founded by Wilson Greatbatch in 1970; IPO in 2000 (NYSE: GB)Leading component supplier to the Cardiac Rhythm Management (CRM) industryHigh growth medical technology marketProven product portfolio of technology leadership products Pipeline of emerging technology opportunities
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Critical Component Supplier
Batteries
Capacitors
Commercial Batteries
Feedthroughs
Enclosures Coated Electrodes
EMI Filters
Engineered Components
Value Add Assembly
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Corporate Strategy
Maintain a strong new product pipeline with advanced proprietary technology
Leverage manufacturing and assembly capabilities to provide best value solution
Drive quality improvements throughout product life cycle
Broaden traditional customer interface
Technology Manufacturing
Quality
Customer
Commercialization
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Facility Locations
Tijuana, MX
Fremont, CA
Carson City, NV
Minneapolis, MN
Western NY
Canton, MA
Columbia, MD
1. Advanced Power Source Plant 2. Battery Plant / R&D Center3. Capacitors Plant4. Machined and Molded Components Plant5. Destructive Analysis Facility6. Sales & Marketing Facility7. Headquarters Facility
9. Feedthrough and Coatings Plant
12. Advanced Research Lab (Nanomaterials)
11. Filtered Feedthrough Plant 8. Commercial Battery Plant
13. Assembly Plant
10. Enclosure Plant
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Sales
83.8
14.0
27.9
25.4
26.1
27.4
190.2172.7
141.9
107.7
0
50
100
150
200
250
2000 2001 2002 2003 2004
Full Year GuidanceElectrochem Commercial PowerImplantable Medical Components
$ Millions
* Represents midpoint of Management’s guidance dated May 3, 2005
$200.1M
$97.8M
$135.6M
$167.3M
$216.3M
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Market & Products
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CRM MarketMarket that deals with electrical problems of the heartBradycardia/TachycardiaCongestive Heart FailureSudden Cardiac Death
Estimated $11 billion market in 200680% of Greatbatch revenues driven by CRM
Customer concentrationMedtronicGuidantSt. Jude MedicalBiotronikELA
30%
10%
36%
24%
GuidantSt. Jude MedicalMedtronicOthers
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Detects abnormally slow heart beat (bradycardia)
Resynchronize ventricular contraction; now combined with ICD + pacing in one device
Detects abnormally fast heart beat (tachycardia); shocks the heart to restore normal function
Function
0 – 4%
35%
10 – 15%
Unit Growth –2005E
Cardiac Resynchronisation
Therapy
Device
Pacemakers
Implantable
Cardioverter
Defibrillators
CRM Devices – Function & Growth
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How It Works
ICD SVO Battery
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ICD Selection Criteria Closely Tied to Power Source Characteristics
Feature Set
Device Lifetime
Charge Times
Programmer & Interface
Shape
Size
Role of Power SourceCriterion
Source: Morgan Stanley CRM Conference 09/03
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Technology Leadership
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Silver Vanadium Oxide: Background
Battery chemistry originally developed at Greatbatch, Inc.
98% of ICDs use SVO as the high rate battery due to its combination of:
High rate capability enabling faster charge times
High capacity enabling longer device lifetimes
Stepped discharge profile enabling easier end-of-life detection
Battery function in ICD
Monitor circuitry on continuous basis
Charge high voltage capacitors in less than 15 seconds
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QSeries Battery TechnologyOur next generation of battery that combines the advantages of two distinct cathode materials via an innovative electrode design
SVO: Low energy density but high rate capabilityCFx: High energy density but low rate capability
Qseries battery technology is the best implantable battery technology available today.
Technology protected by IP5 years of real-time data
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Innovation in
Nanotechnology
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NanoGram Devices Corporation
Spun out of NanoGram Corporation in August 2002Leader in nanomaterials enhanced power sources; developed NanoSVO for implantable medical devicesRaised $9.2MM in Series A financing led by Venrock, Bay Partners, and Nth Power (January 2003)Acquired by Greatbatch in March 2004 for $45MM; currently Advanced Research Laboratories
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Nanoparticle Manufacturing Technology (NPM™)
Unique FeaturesAuto nucleation due to abrupt
temperature changeSize growth control due to quenchingWall free reaction zone reduces contaminationUniform laser reaction zone chamber
Engineering BenefitsFlexible design of reactor by opticsProgrammable control of process
CapabilityControl of grain growthUniform sizeHigh chemical purity
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Technology Benefits
Nozzle Length (mm)
Thro
ughp
ut (
kg/h
r)
Complex compositions
Highly reproducible
Controlled properties
Scaleable---VOX 702 ---VOX 709 ---VOX 716 ---VOX 703 ---VOX 710 ---VOX 717 ---VOX 704 ---VOX 711 ---VOX 718 ---VOX 705 ---VOX 712 ---VOX 719 ---VOX 706 ---VOX 713 ---VOX 720 ---VOX 707 ---VOX 714 ---VOX 722 ---VOX 708 ---VOX 715
VO2
---VOX 702 ---VOX 709 ---VOX 716 ---VOX 703 ---VOX 710 ---VOX 717 ---VOX 704 ---VOX 711 ---VOX 718 ---VOX 705 ---VOX 712 ---VOX 719 ---VOX 706 ---VOX 713 ---VOX 720 ---VOX 707 ---VOX 714 ---VOX 722 ---VOX 708 ---VOX 715
VO2
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NanoSVO TechnologyNanoscale version of bulk SVOPrecisely tailored nanocrystalline structure yielding
low impedance and high power capability
High power capability
Low impedance
Greater stability
Smaller size
Improved design flexibility
Technology Benefits
AnodeCurrent Collector
LOAD
Li +
Li +
Li +
Bulk CathodeElectrolyte
+ -
Anode
LOAD
Li +
Li +
Li +
Nano Cathode
Current Collector
Electrolyte
+ -
Bulk Nano
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Higher Current or
“Rate” Capability
Low Impedance
Shorter Charge Times
Greater Capacity
per Volume
Longer Lifetimes
Nanotechnology Benefits Dramatic in Medical Implantable Power Source Market
“Fast Lithium
Transport”
Nano-enhanced Cathode Has Better
Accessibility for Lithium Ions
