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COMPARISON BETWEEN THEEFFECTIVENESS OF INTRAVENOUS AND

INTRAMUSCULAR MAGNESIUM SULPHATEADMISSION IN SEVERE PREECLAMPSIA

Renaldy, Tun Ali Ibrahim, Wim T P, Azhari, Mutiara B A

Obstetric and Gynecology Departement,Faculty of Medicine Sriwijaya University,Mohammad Hoesin Hospital, Palembang

Objective: To compare the effectiveness between

intravenous magnesium suphate and intramuscular insevere preeclampsia patient, based on gestosis index,

and ion Magnesium value

Material and method: This is a randomized clinical trial

that was performed to 26 pregnant women with severepreeclampsia in Obstetric and Gynecology Department

ward, between 17 April 2009 until 17 December 2009.The data analysis using Chi-square test and multiple

logistic regression analysis

Result: Mean age of the study sample for theintravenous group is 29,65 6,35 years, and 29,81

6,99 years in the intramuscular group. Meanmagnesium ion value was 1,860,43mg/dl in the

intravenous group and 1,950,47mg/dl in theintramuscular group. Mean magnesium ion value in

severe preeclampsia patient 4 hours after the

magnesium sulphate admission was 3,680,94mg/dl inintravenous group and 3,731,19mg/dl inintramuscular group. Mean magnesium ion value in

severe preeclampsia patient 6 hours after themagnesium sulphate admission was 3,43 0,85mgdl in

intravenous group and 3,37 1,04mg/dl inintramuscular group

Conclusions: There are no significant differencesbetween mean magnesium ion value in severepreeclampsia patient before, after 4 hours, and 6

hours after the magnesium sulphate admission,through intravenous or intramuscular

Bibliography:

1. Bailis A, Witter FR. Hypertensive Disorders ofPregnancy, In The John Hopkins Manual of

Gynecology and Obstetrics, LippincootWilliams&Wilkins;2007.p180-91

2. Sibai BM, Graham JM, McCubbin JH. AComparison of Intravenous and Intramuscular

Magnesium Sulfate Regimens in Preeclampsia,Am J Obstet Gynecol, November 15, 1984;

150:728-333. Szal SE, Croughan-Minihane MS, Kilpatrick SJ.

Effect of Magnesium Prophylaxis andPreeclampsia on the Duration of Labor, Am J

Obstet and Gynecol, 1999; 180:1475-9

Figure 1. Magnesium2+ ion levels distribution before theadministration of intravenous and intramuscular magnesiumsulfate

Figure 2. Magnesium2+ ion levels distribution after 4 hoursof intravenous and intramuscular administration ofmagnesium sulphate

Figure 3. Magnesium2+ ion levels distribution after 6 hours ofintravenous and intramuscular administration of magnesiumsulphate

evels distribution after 4 hours of intravenous and intramuscular administration of magnesium sulphate