rodent model of stroke by using both functional outcome measuresand kinematic measures of limb movement patterns.Design: A randomized, placebo-controlled study in rodents.Setting: An animal research laboratory.Participants: Adult male Long Evans black-hooded rats (n�12).Interventions: The animals were trained in a skilled forelimbreaching task and then underwent surgical occlusion of the middlecerebral artery, which produced a stroke that impaired the trainedpaw. One week after stroke, the animals were randomly assigned toeither a stem cell (SC) or vehicle control (VC) group. Measurementsof reaching behavior were then compared at baseline and at 10weeks after stroke (PS-Wk10).Main Outcome Measures: Outcome scores (the number ofpellets retrieved) and forelimb kinematics (zero crossings and in-flections in the velocity profile).Results: Both groups improved their outcome scores during the10-week recovery period. However, the SC group recovered signif-icantly more function than the controls in terms of outcome mea-sures. Furthermore, the animals in the VC group appeared toimprove their functional performance by using compensatory strat-egies that involved an increased number of trajectory adjustments,whereas the SC-treated group’s kinematics more closely resembledtheir prestroke performance.Conclusions: Our findings demonstrate that rodents treatedwith hABM-SC therapy experienced enhanced motor recovery afterstroke and also used fewer compensatory trajectory adjustmentscompared with controls. Furthermore, this study demonstrates thatkinematic measures established in stroke research on humans arealso sensitive to performance differences pre- versus poststroke inthe rodent model, which reinforces the utility of this method toevaluate treatments that may ultimately translate to patient popula-tions.

Poster 92The Identification of Transient AlteredConsciousness Induced by Military-related BlastExposure and Its Relation to PostconcussionSyndrome.William C. Walker, MD (Virginia Commonwealth Univer-sity School of Medicine, Richmond, VA, United States);David X. Cifu, MD, Jessica M. Ketchum, PhD, Scott D.McDonald, PhD, Michelle Nichols, MSN, RN.

Disclosures: W. C. Walker, Congressionally Directed MedicalResearch Program, PT074224, research grants.Objective: To analyze the interim agreement and relationship tocurrent symptoms of questionnaire responses for recalled symp-toms of altered consciousness in subjects who may have sustained ablast-associated mild traumatic brain injury (TBI) in the past 2years.Design: A prospective cohort study.Setting: Outpatient clinics at a Veterans Affairs polytrauma reha-bilitation center and participating military treatment facilities.Participants: Eighty-nine active duty or veteran subjects whoexperienced acute effects from a blast within the past 2 years whiledeployed in support of Operations Enduring and Iraqi Freedom;Severe TBI was an exclusion criterion.Interventions: Not applicable.Main Outcome Measures: Standardized, self-report mea-sures of current postconcussive symptoms (PCS) by using the

Rivermead Post-Concussion Symptom Questionnaire (RPQ), post-traumatic stress disorder (PTSD) by using the PTSD Checklist,Civilian Version (PCL-C), depression by using the Centers forEpidemiological Studies Depression Scale (CES-D), and pain byusing the Short Form McGill Pain Questionnaire (SF-MPQ).Results: Thirty-one subjects (34.8%) responded positively to atleast 1 of 3 concrete altered consciousness items: gap in memory(19.1%), memory not continuous (15.7%), and/or told by observerthey had loss of consciousness (LOC) (21.3%). There was evidenceof significant agreement between memory gap and memory notcontinuous (87.6% concordant; ��0.57 [95% confidence interval,0.35-0.80]). As expected, because LOC is not necessary when thereis amnesia, concordance was lower between LOC and memory notcontinuous (80.9% concordant), and between LOC and memorygap (77.5% concordant). Each altered consciousness item was pre-dictive of current symptom distress.Conclusions: All altered consciousness questionnaire responsesthat suggested TBI were predictive of current symptom distress inthis population. Some inconsistencies were found in subjects’ itemresponses, which suggests a structured interview may improvediagnostic accuracy for TBI.

Poster 259Effect of Partial Weight-supported Treadmill GaitTraining on Balance in Patients With ParkinsonDisease.Anupam Gupta, MD (National Institute of Mental Healthand Neurologic Sciences, Bangalore, India); MohanGanesan, MPT, Pramod Pal, DM, Satyaprabha Talak-kad, MD.

Disclosures: A. Gupta, none.Objective: To evaluate the effect of partial weight-support tread-mill training (PWSTT) on balance in Parkinson disease (PD).Design: Sixty patients with idiopathic PD from Hoehn and Yahrstage 2-3, on stable doses of dopaminomimetic drugs were ran-domly assigned into 3 groups. Group I (controls) did not receive anyspecific intervention, group II underwent conventional gait training(CGT) and group II underwent PWSTT, with 20% unweighing.Training was given for 30 minutes per day, 4 days per week for 4weeks (16 sessions). Both groups were evaluated in best “ON” state,by using the unified PD rating scale (UPDRS) and Dynamic Postu-rography, which measured overall balance index (OBI), anterior-posterior index (API), mediolateral index (MLI), and the limits ofstability (LOS) in 8 directions. Evaluations were done before andafter 4 weeks of training.Setting: Neurologic rehabilitation division, tertiary university re-search hospital.Participants: Sixty patients with idiopathic PD.Interventions: Randomized control trial. Patients randomized in 3groups. Group I (controls) did not receive any specific intervention,group II underwent conventional gait training (CGT), and group IIunderwent PWSTT with 20% unweighing. Training was given for 30minutes per day, 4 days per week for 4 weeks (16 sessions).Main Outcome Measures: Dynamic posturography, whichmeasured overall balance index (OBI), anterior-posterior index(API), mediolateral index (MLI), and the limits of stability (LOS) in8 directions.Results: After 4 weeks, significant group effect was observed be-tween the groups in OBI (F�6.57; P�.039), API (F�5.17;

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P�.009), and MLI (F�8.81; P�.001), LOS total score (F�16.76;P�.001) and all 8 direction scores. Occasion effect was significantbetween the groups except backward direction. Bonferroni adjustedcomparison showed improvement in all subcomponents of LOSonly in PWSTT group after 4 weeks. No significant improvementwas observed in CGT group.Conclusions: PWSTT improved dynamic balance and limits ofstability in all direction in PD. Four weeks training was optimum.

Saturday, November 19, 201111:00 AM - 12:00 PMTampa, Level 2, Convention Center

802. BEST RESEARCH PRESENTATIONS –MUSCULOSKELETAL MEDICINE

Poster 135Dietary Intake as a Predictor of Low Bone Densityin Young Female Runners.Lauren Sayres, BA (Stanford University, Stanford, CA,United States); Julia Arroyo, MD, Hervé Collado, MD,Phil Cutti, MSc, Michael Fredericson, MD, Kristin Sainani,PhD, Adam S. Tenforde, MD.

Disclosures: L. Sayres, none.Objective: To test the hypothesis that reduced consumption ofcalcium-rich foods is associated with low bone density in youngfemale runners and to explore whether other nutritional factors arepredictive of bone density.Design: Cross-sectional design.Setting: University human performance laboratory; online ques-tionnaire.Participants: 87 female high school distance runners (age,15.4�1.1 years; body mass index [BMI], 20.0�2.4 kg/m2).Interventions: The subjects completed a questionnaire regardingnutritional factors of interest, including intake of calcium-contain-ing foods and supplements, and a modified Food Frequency Ques-tionnaire. The subjects also received a dual-energy x-ray absorpti-ometry scan that assessed bone mineral density (BMD) at multipleregions, including lumbar spine (LS), femoral neck (FN), pelvis (P),and total body (TB); BMD values were adjusted for age, height,weight, and race.Main Outcome Measures: Association of nutritional variablesto regional BMD values.Results: We observed significant associations between consump-tion of milk (��0.246), dairy products (��0.249), and dietaryphosphorous (��0.556) and TB BMD (P�.05). We also observedseveral nonsignificant trends (P�.10): consumption of calcium-containing multivitamins, dietary protein, and overall caloric intakeand TB BMD were positively related; iron intake was inverselyrelated to LS BMD; and consumption of caffeinated beverages wasinversely related to FN BMD. Nutritional variables were adjusted fortotal caloric intake.Conclusions: Milk, dairy products, and supplements are sources ofcalcium that correlate with higher TB BMD in this population. Dietaryphosphorous and protein may also be related to higher TB BMD. Fewassociations of nutrition to improved LS BMD were observed, and lowLS BMD values have been previously reported in this population.

Overall, nutritional intake represents a modifiable risk factor for BMDand is particularly important in young female runners due to height-ened risk of poor skeletal health and bone-related injuries.

Poster 83A Randomized Controlled Trial on the Effects ofOral Collagen Treatment on the Medial Knee JointSpace and Functional Outcome Among PatientsDiagnosed With Osteoarthritis of the Knee.Maria Lourdes R. Bernardo, Doctor of Medicine (Veter-ans Memorial Medical Center, Quezon City, Philip-pines).

Disclosures: M. R. Bernardo, none.Objective: To determine the effects of the intake of oral collagenversus nonsteroidal anti-inflammatory drugs on the medial kneejoint space and the functional outcome among patients diagnosedwith osteoarthritis of the knee.Design: Randomized, single blind, open-labeled, controlled trial.Setting: Outpatient.Participants: 113 patients randomly assigned to group A (n�55)or B (n�58).Interventions: Group A subjects received oral collagen hydroly-sate, 400 mg/capsule, 3 capsules once a day at bedtime. Group Bunderwent the conventional treatment of nonsteroidal anti-inflam-matory drug for 5 days then as needed for pain. Both groups alsowere prescribed with topical analgesic to be applied twice a day asneeded for pain, and physical therapy treatment thrice a week for 2weeks. Follow-up evaluation was done every month to assess devel-opments from the symptoms. Initial radiograph of the knee wasdone before the intake of the medications and repeated after 6months of completion of the intervention.Main Outcome Measures: Western Ontario and McMasterUniversities (WOMAC) Knee Osteoarthritis Index, Likert Scale andmeasurement of the radiographed medial compartment of the tib-iofemoral joint by using a standard ruler in millimeters.Results: Patients in group A scored significantly lower in theaverage WOMAC score from baseline to the 6th month follow-up(P�.04), whereas group B had no significant change in their averageWOMAC score after 6 months (P�.21). There was no significantdifference in the medial knee joint space measured at baseline andafter 6 months in both groups (group A, P�.42; group B, P�.32).Conclusions: The administration of 1200 mg of collagen hydro-lysate daily for a period of 6 months has a beneficial impact on painsymptoms and joint function in patients with osteoarthritis.

Poster 133Determinants of Physical Activity: A FirstCharacterization of the Nationally RepresentativePhysical Activity Database in National Health andNutrition Examination Survey.Ming-Chih J. Kao, PhD, MD (Stanford University MedicalCenter, Palo Alto, CA, United States); Michael Goldin,Amy Patel, Matthew Smuck, MD.

Disclosures: M. J. Kao, none.Objective: To characterize physical activity measurement in rela-tion to demographics, anthropometrics, behaviors, and comorbidities.Design: Cross-sectional population-based survey.Setting: A population-based survey.

S164 PRESENTATIONS