Portfolio Vetra - Overview
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Transcript of Portfolio Vetra - Overview
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B I O C E R M I C A S DE ALTA
TECNOLOGIA PARA
F A B R I C A N T E S DE BIOMATERIAIS
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A THIRD GENERATION BIOMATERIAL
Vetra developed a bioglass with enhanced bioactivity. It means it can induce a specific positive response of the body and is also totally bioabsorbable, which eliminates the need for a second surgical removal procedure.
OSSEOINDUCTIVE
HIGHLY BACTERICIDAL AGENT
NO SIDE EFFECTS
GREEN FRIENDLY PRODUCTION
REGENERATES SOFT TISSUES AND NERVES
TOTALLY BIODEGRADABLE
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OUR PRODUCTS AND AVAILABLE FORMS monoliths, powder (particle size range: 5m to 2 mm), granules, 3D
shapes, scaffolds, fibers and meshes.
BIOFUNCTIONALIZATION DENTAL AND ORTHOPAEDIC
IMPLANTS
BIOACTIVES PADS AND FIBERS
COSMETIC PRODUCTS
POWDERS AND GRANULES
(BONE GRAFTING)
HIGH STRENGTH SCAFFOLDS
(HIGHLY POROUS 3D STRUCTURES)
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IN VITRO AND IN VIVO TESTS COMPENDIUM
IN VITRO Citotoxicity, genotoxicity, Immunologic (Oxidative burst), Antibacterial Test (ISO 22.196:2011), Bioactivity (ISO 23.317:2007)
IN VIVO Bone healing, skin regeneration, biofunctionalized implants.
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IN VITRO TESTS - RESULTS OVERVIEW
Osteoblasts Osteosarcoma cells Fibroblasts (animal) Human Fibroblast.
citotoxicity
Non cytotoxic Stimulates Cell Adhesion and Proliferation
Fibroblasts Osteoblast and Sistemic
genotoxicity
Biocompatible Non genotoxic (No DNA damage)
Macrophages Neutrophils
Immunologic (Oxidative Burst)
Less inflammatory reactions
Simulated Body Fluid (SBF)
Bioactivity (ISO 23.317:07)
Highly Bioactive
S. aureus S. epidermidis P. aeruginosa E. coli
Antibacterial Test (ISO 22196:11)
Bactericide for all bacteria Killed up to 99,9999% of bacteria.
IN VIVO TESTS - RESULTS OVERVIEW
tibia defects in rats
bone healing
Stimulated faster bone regeneration
Improved Mechanical Properties of newly formed bone
Higher expression of collagen type I, RANK-L and RUNX-2
Calvaria defects in rats
bone healing
Stimulated bone regeneration
denser neobone
3 Degree Burned Skin (rat study)
Skin regeneration
Stimulated faster skin regeneration
Higher expression of VEGF and TGF- factors.
Osseointegration in dogs mandible
biofunctionalized
implants
Osseointegration 1,5 faster (2weeks)
Peripheral Nerve (rat study)
nerve regeneration
Faster Nerve Regeneration
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ONGOING TESTS
Antibacterial
In Vitro
Antibacterial
In Vitro
Biofilm Reduction
Antibacterial
In Vivo
Bone Healing
Clinical
Minimum inhibitory
concentration.
E.N.T. (ears, nose
and throat)
infections
Alveolar
augumentation