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Dr. M. Gossell-Williamsmaxine.gossell@uwimona.edu.jm

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To cover the nutraceuticalusefulness of polyphenols

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naturally occurring compounds

mainly ANTIOXIDANTS

found largely in the fruits & vegetables

e.g. grapes, apples, pears, cherries and various berriescontains up to 200-300 mg /100 grams fresh weight.

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100 mg polyphenols =

cup of tea or coffeeglass of red wine

http://rds.yahoo.com/_ylt=A0PDoTGj8JJNMS8A06GjzbkF/SIG=12uk59qgf/EXP=1301504291/**http%3a//upload.wikimedia.org/wikipedia/commons/1/1f/Brown_cup_of_coffee.jpghttp://rds.yahoo.com/_ylt=A0PDoX1I8JJN9ToAsjWjzbkF/SIG=130kv6js5/EXP=1301504200/**http%3a//www.scenicreflections.com/files/Glass_of_Red_Wine_Wallpaper_taa51.jpg

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1.Phenolic acidsGallic acid

Caffeic acid

Source

Blueberries, oilseed,apricots

2. StilbenesResveratrol

Sources

Grapes, Peanuts,

Pomegranate

3. LignansExamples

Secoisolariciresinol

Sources

Flax seed,

Pumpkin seeds,

Sesame seed

4. Flavonoids

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Flavonols

Flavanones

Flavanols Flavones

Anthocyanins

Isoflavones

FLAVONOIDS

Quercetin

Kaempferol

Myricetin

proanthocyanidins

NaringeninHesperetin Epicatechin

Catechin

Gallocatechin

Apigenin

Luteolin

Cyanidin

Delphinidin

Malvidin

Daidzein, Genistein

Sources: Apples, Grapes, Onions, Soya beans, Cranberries

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Phytoestrogens = Oestrogenic-like qualities(phytoestrogen) :1000 x LESS

LIMITED EVIDENCE

reduce menopausal symptoms

prevention of bone resorption

(osteoporosis) in post-menopausal

women

Reduce LDL and increase HDL

http://ods.od.nih.gov/News/The_Scoop_-_October_2011.aspx#6

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Genistein supplements

Sold in 1000 mg supplements

Recommended for menopausal

women

1 -2 capsules per day

Soya Vaginal Gel.

Contains soyabean extract with 10%

isoflavone

Use for vaginal dryness associated with

menopause.

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Contain mainly epicatechins

CV benefits- decrease systolic BP

Capsules and tablets = 50 to 100 mg per day ofextract

Dose: 1 capsule /day of a 100mg preparation

Contains cathechin

Decreases TC and LDL

Major component of Green tea extract

Dose: Not yet standardize

250-300 mg daily

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CONTAINS Proanthocyanidins

UsesAntioxidant , Prevent UTIs

Proanthocyandins of cranberry prevent E. coliadhesion to urinary tract

More research required

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Good scientific evidence-more studies needed

Suggest more useful for recurrent UTIs

reduces adherence of bacteria to cells lining thebladder thereby reducing UTI

800-900 mg daily-oral

Cochrane Database Syst Rev. 2008 Jan 23;(1):CD001321

Possible stone formation dueto oxalate composition canoccur with excessiveconsumption.

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Main component= Secoisolareciresinol

Phytoestrogens

Shown to reduce plasma cholesterol and

reduce arthrosclerosis

Flax seed- purported usefulness in

menopause, including reduce risk of breast

cancer

More research required

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PRESCRIBED TEXT

1. Dietary Supplements Pamela Mason

WEBSITES

1. Medline Plus

2. National Centre for Complementary &Alternative Medicine

3. Office of Dietary Supplements