Policy Levers and Strategies - National Academies
Transcript of Policy Levers and Strategies - National Academies
MakingtheLivingWorldEngineerable- Synthe7cBiology,theUKApproachLionelClarke,co-chairmanUKSynthe6cBiologyLeadershipCouncil*NAS,WashingtonD.C.16Nov2016*Note:presenta6onrepresentsapersonalreflec6on,notanofficialviewoftheSBLC
PolicyLeversandStrategies
Whatisthe(UKSynthe6cBiology)Roadmap?1
Ø Todevelopemergingpla6ormtechnologywithmul:plepoten:alapplica:onsintoaneffec:vecapabilitydeliveringclearvalue
Ø NOTaprojectplantoafixedtarget…astraightroad…...morelikeahikingmapinunfamiliarterritory…orperhapsaguidetose6ngupaNa8onalPark–wheretobuildpathsandbridges,wheretopostwarningsignsandsetupsafetybarriers…
Whatisthe(UKSynthe6cBiology)Roadmap?2
Ø Drivenbyunmetneeds,spanninghealthtosustainableenergyØ notaprojectplantowardsasetendpoint,yetpurposeful
Ø Aguidingframework,reflec:ngcommiHeeconsensusØ alignedbehindacommonvisionandvaluesystemØ relevantdepartmentsandstakeholdersremainresponsiblefordelivery
Ø Speedandefficiencyenhancedbyan:cipa:ngfutureapplica:onsØ S7mula7ngdiscussionsandac7onswellinadvanceofpoten7aldeployment
Ø MechanismforassessingprogressandreshapingasneededØ follow-updocumentsbuilduponoriginalRoadmapfounda7on,notdisplace
TheUKApproach
Ø Synthe:cBiologyiden:fiedasapoten:allysignificantscien:ficgrowthareawithacademicstrengthintheUKØ PublicDialogue2011providedpreliminaryguidanceØ ….buthowtorealiseitspoten7al?
Ø ConveneaRoadmapCoordina:onGroupØ Ledbyanindustrialist,butwithkeystakeholderrepresenta7onØ BroaderengagementviaworkshopsandSpecialInterestGroupØ Governmentobservers,butindependentrecommenda7ons
Ø ConveneaLeadershipCounciltooverseeprogress,updateandre-steerasneededØ Sub-groupsandOpenMee7ngstoenablemoreinclusionandengagement
Vision:…ofasynthe7cBiologySectorthatis:Ø economicallyvibrant,diverseandsustainable:
wherebusinessesaresuccessfullydevelopingandintroducingnewproducts,processesandservices–leadingtosignificantrevenuesandemployment
Ø cuSngedge:leadingscien7ficadvancesandwitharesilientplaVormofunderpinningtechnologies–deliveringclearadvantagesinapplica7ondevelopment
Ø ofclearpublicbenefit:anexemplarofresponsibleinnova7on,incorpora7ngtheviewsofarangeofstakeholdersandaddressingglobalsocietalandenvironmentalchallengeswithinaneffec7ve,appropriateandresponsiveregulatoryframework
Ø Learnfrompast–GMOsandotherexperiencesØ Technologymustbedevelopedinasociallyresponsible
fashion–‘ResponsibleResearchandInnova7on(RRI)’Ø UKneedstobe,andbeseentobe,leadingthewayin
frameworksandmethodologiesforRRIØ RelevantStakeholders,RegulatorsandPublicsshouldbe
engagedinprocessesfromoutset;SocietyhastobeEnrolledØ GatherpreliminaryviewsviaPublicDialogue(2011)
ValueSystem
fivekeyques6onsthatsynthe6cbiologistsshouldbewillingandabletoanswer:
Ø whatisthepurpose?Ø whydoyouwanttodoit?Ø whatareyougoingtogainfromit?Ø whatelseisitgoingtodo?Ø howdoyouknowyouareright?Addedtowhichweshouldalsobepreparedtoconsider:Ø Whatmaybetheconsequenceofnotdoing?
ResponsibleResearchandInnova7on
2011
July2012Roadmap:BuildingFounda7ons-mul7disciplinarycentres,communityandvaluesystems
Jan2013Synthe7cBiologyPolicy:oneofthe‘EightGreatTechnologies’
Synthe:cBiologyUK:anindependentlycoordinatedresponsetoastrategicchallenge
1+6SBRCs,2DTCs&1IKCestablished:ExtendingUKFounda7onalandTransla7onalCapability
CambridgeUniversityandJohnInnesCentrevImperialCollegeLondon
2009
Synthe6cBiologyDoctoralTrainingCentre
SBRCs:Synthe6cBiologyResearchCentresDTC:DoctoralTrainingCentresIKC:Innova6onandKnowledgeCentre
+Governancesub-group+Sci&Techsub-group+BIASynBioAdvisoryCommifeealsoworkingwithBSI,NPL
UKSynthe:cBiologyLeadershipCouncilCo-Chairmen:Prof.LionelClarkeRt.Hon.DavidWillefs(2012-14)GeorgeFreemanMP(2014-16)
Dstl
Synthe7cBiology–anadvancingfron7er?
Synthe7cBiologystemsfromconfluenceofmodernsmartdata-intensivetechnologieswithadvancingbiologicalunderstandingatthegene7clevel
Ø ‘AnaloguetoDigitalRevolu:oninBiology’Asaresultofgreaterautoma7onandtheapplica7onofengineeringprinciplesofcharacterisa7on,standardisa7onandmodularisa7ontobiologicalsystems,predictabilityanddevelopmentspeedscanbeincreasedandcostsreduced
DomainofSynthe7
cBiology
‘Analogue’
‘Digital’
Design
BuildTest
Produce
Analyse
Registriesofstandardizedparts
EngineeringPrinciplesofcharacterisa7on,standardisa7on,modularisa7on
1953:DiscoveryofstructureofDNACrickandWatson
1990-2003HumanGenomeProject
1984:DNAfingerprin7ng
1970’s:gene7cengineeringdeveloped
HighThroughputAnalysistechniquesdeveloped
CostsofReadingandWri7ngDNAreduced
Costsofdatahandlingandanalysisreduced
Rapid,accurategene-edi7ngtoolsdeveloped(e.g.CRISPR)
SpeedandPredictabilityincreased
Biodesign
Design-to-outcomeprocessesaccelerated
Synthetic Biology: a timely response !linking technological potential to market needs !
Ref:UKSynthe6cBiologyRoadmapJuly2012
GlobalChallengesandNeedsIncreasingeffec7venewsolu7onsbecomingtechnologicallypossibleandcommerciallyviable
‘RapidbutnotHasty’valuesystem,regulatorydevelopment,governanceandsocialengagementembeddedinRoadmapandStrategicPlan
Synthe:cBiology
Design
BuildTest
Produce
Analyse
Biodesign
RapidTechnologicalDevelopmentDNAsequencing,synthesisandautomatedhigh-throughputanalysisincreasingspeedandpredictabilityDNAdesignandgeneassemblybecomingmuchcheaperandmorewidelyaccessible,facilita7ngroutestoinnova7vebio-basedsolu7ons
Commercial considerations provide !a further set of checks and constraints !
Ø Whatistheneed?Ø Howeffec7vearecurrentsolu7ons?Ø Howcouldanimprovedsolu7onhelp?Ø Howcouldsynthe7cbiologycontributetowardsgenera7ngthissolu7on?
Ø Howwillsuitabilityandacceptabilitybechecked?
hfps://connect.innovateuk.org/web/synthe7c-biology-special-interest-group/2016-uk-synbio-strategic-plan
UKSynBioStrategicPlan2016LaunchEvent:24Feb2016
July2012Roadmap:BuildingFounda7ons-mul7disciplinarycentres,communityandvaluesystems
Jan2013Synthe7cBiologyPolicy:oneofthe‘EightGreatTechnologies’
Feb2016StrategicPlan2016:commercialisingapplica7ons
Synthe:cBiologyUK:anindependentlycoordinatedresponsetoastrategicchallenge
Synthe7cBiology–2016UKStrategicPlanmappingoutroutestoindustrialisa7onandcommercialisa7onfrominnova7veresearchbase
SupplyingthePipelinewith
Op7ons
Transla7ngInves7ng
Commercialising
DevelopingEconomicandSocialValue
EXPERTWORKFORCE
SUPPORTIVEBUSINESS
ENVIRONMENT
INDUSTRIALISATIONANDCOMMERCIALISATION
EFFECTIVETOOLKITS
EFFICIENTENTERPRISE
Standards&Metrology
DesignTools
Leading-edgeAccessible
infrastructure
NetworkedandPartnered
Value-driven
Transla:onandDeliveryFocus
Skilled
Entrepreneurialmindset
StructuredTraining
Confidencetoinvest
Effec:veGovernance
Responsiblestewardship
HEALTHYRESEARCHBASE–INNOVATIVEOPTIONS
QuickWinsGrandChallengesandAspira:ons
SBLC
Agility
Responsiveness
Coordina:on
UKSynthe7cBiology–Interna7onalPartnerships
• UKhassetouttobeamongsttheworldleadersinsynthe:cbiology.Coordinatedinvestmentsandini:a:veshelpingtoachieveandbenefitfromthis.– over£300minvestedinR&Dtodate,plusprivateinvestments.SecondonlytotheUS.– seekingtoleverageinvestmentstodatetoretainini7a7veandafractfurtherinvestments
• Informa:on-basedpla6ormlendsitselftogeographicallydistributedopera:ons– opportuni7esarisingindevelopingaswellasdevelopedmarkets– UK-basedcommercialapplica7onsfordevelopingmarketsincludearsenicsensorforcleanwater,
controlofmosquito-bornediseasessuchasZika,bespokedrugsandvaccineproduc7on
• Interna:onalpartnershipsanimportantfeatureofrecentdevelopmentofthefield– shapedthroughworkshopsandjointresearchprogrammeswithUS,Europe,Chinaandothers– seekroleas‘partnerofchoice’–valuableinestablishingstandards,regula7ons,accesstomarkets– interna7onaltrainingandresearchpartnershipsincludeLEAP,synberc,iGEMandERA-SynBio