PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh...

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PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1 , Jayesh Desai 2 , Emily Chan 3 , J Randolph Hecht 4 , Peter J O’Dwyer 5 , Richard J Lee 6 , Keith B Nolop 7 , Suman Bhattacharya 8 , Leonard Saltz 9 1 The University of Texas M.D. Anderson Cancer Center, Houston, TX; 2 Royal Melbourne Hospital, Parkville, Australia; 3 Vanderbilt-Ingram Cancer Center, Nashville, TN; 4 David Geffen School of Medicine at UCLA, Los Angeles, CA; 5 Abramson Cancer Center at University of Pennsylvania, Philadelphia, PA; 6 Roche, Nutley, NJ; 7 Plexxikon, Berkeley, CA; 8 Genentech, Inc., South San Francisco, CA; 9 Memorial Sloan-Kettering Cancer Center, New York, NY

Transcript of PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh...

Page 1: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors

Scott Kopetz1, Jayesh Desai2, Emily Chan3, J Randolph Hecht4 , Peter J O’Dwyer5, Richard J Lee6, Keith B Nolop7, Suman Bhattacharya8, Leonard Saltz9

1 The University of Texas M.D. Anderson Cancer Center, Houston, TX; 2 Royal Melbourne Hospital, Parkville, Australia;

3 Vanderbilt-Ingram Cancer Center, Nashville, TN; 4 David Geffen School of Medicine at UCLA, Los Angeles, CA;

5 Abramson Cancer Center at University of Pennsylvania, Philadelphia, PA; 6 Roche, Nutley, NJ;

7 Plexxikon, Berkeley, CA; 8 Genentech, Inc., South San Francisco, CA;

9 Memorial Sloan-Kettering Cancer Center, New York, NY

Page 2: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 3: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 4: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 5: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 6: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 7: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 8: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 9: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 10: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 11: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 12: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 13: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 14: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534

Page 15: PLX4032 in Metastatic Colorectal Cancer Patients with Mutant BRAF Tumors Scott Kopetz 1, Jayesh Desai 2, Emily Chan 3, J Randolph Hecht 4, Peter J O’Dwyer.

Kopetz, Desai, et al ASCO 2010 Abs# 3534