John Sebastián Henao Espinosa

Medical Student

July 16,2012

STUDY SHEDS LIGHT ON THE ASSEMBLY OF RIBOSOME

AND STOP AND GO: ‘TRAFFIC OFFICER’ PROTEIN DIRECTS

CRUCIAL STEP IN CELL DIVISION

INTRODUCTION

• Ribosomes, site of research to find cure

for cancer• ARN, the language

of the life

• Phosphate, the new traffic officer found.

• It is the same mechanism for all!

• how is the beginning of our life? Look at the cell

division process

“Scientists from the Florida campus of The Scripps Research Institute have identified a series of intricate biochemical steps that lead to the successful production of proteins, the basic working units of any cell”

News Medical

(July 6, 2012 )

Study sheds light on the assembly of ribosome

Study sheds light on the assembly of ribosome

The study gave new insights about the essambly of the

ribosomes

They are the

target of many

used antibiotics

it is seen like a promising area of research because of the importance of the ribosome function for cell growth

There are well-established links

between defects in ribosome assembly

and cancer

Study sheds light on the assembly of ribosome

If the translation process acts on the subunits prematurely, would be found a production of incorrectly assembled proteins.

to producing functional ribosome there are two steps:1) in the nucleolus, a protein-nucleic acid structure inside the nucleus .2) in the cytoplasm, the basic cellular stew where protein translation occurs.

At translation, the ribosome decodes information carried in mRNA to produce a chain of aminoacids

Study sheds light on the assembly of ribosome

“Does the conversion of inactive assembly intermediates into mature ribosomes require checkpoints to assure that subunits are functional?”

“What is important here is that the test cycle involves the same translational factors that are involved in normal translation”

They showed that during this translation-like cycle the newly made ribosome subunit joins with its complementary preexisting subunit to form a much larger complex

Said Karbstein

Final Conclusion

OBSERVATION

Thanks to this study, scientists can learn more about the

different process of the RNA with the end of attempt to find

different ways to repair the problems with the assembly of the ribosomes and beforehand,

finding new drugs that could combat strong diseases like cancer. In addition, I think its

fascinating to see this mechanism is conserved in creatures ranging from one-

celled organisms to humans .

Stop and Go: ‘Traffic Officer’ Protein Directs

Crucial Step in Cell Division

“The EMBL scientists discovered a new molecule, Lem4, which acts as a traffic officer, stopping one protein from adding phosphate tags to BAF and bringing in another protein to remove the existing tags.“This happens in both human cells and in the worm C. elegans, so it seems to be a strategy which evolved long ago," says Iain Mattaj, director general of EMBL”

Science Daily

( July 6, 2012 )

Stop and Go: ‘Traffic Officer’ Protein Directs Crucial Step in Cell Division

The cells divides to give rise to two cell

a protein called BAF performs this function throught phosphates removed

the nuclear envelope - has to be broken down and later rebuilt

The availability of phosphate Tags can involve regulating the activity of proteins that add phosphate an proteins that remove phosphate.

Stop and Go: ‘Traffic Officer’ Protein Directs Crucial Step in Cell Division

Lm4

Because they Stop one protein

They remove TheyAdd

Why is it called like traffic officer?

AND?

phosphate tags to BAF

• Although the human version of Lem4 is different that the worm version, both perform the same funciton at the final of the cell division

• Now, there is to investigate which is the need of Lem4 to start its double-action at the right moment

Stop and Go: ‘Traffic Officer’ Protein Directs Crucial Step in Cell Division

OBSERVATION

In my opinion, is a greatest form of deepen at the subject of molecular biology, knowing

about it and looking for the form of learning each day

more. The discovery of Lem4 is the

best opportunities to understand the mechanism of cell division, and find possible

cures to new diseases.

MEDICAL UTILITYSTUDY SHEDS LIGHT ON THE ASSEMBY

OF RIBOSOMA

Ribosomes can be used like molecular target drugs.

Learning new ways to attack several diseases like cancer

Knowing about the role of ARN at the transcripition process with the end of understand how is the structural, enzymatic and conveyor operation of the new proteins.

MEDICAL UTILITYstudy sheds light on the

assemby of ribosoma

Knowing perfectly the cell division process and the form like it is regulated by this new molecule. It´s important for future research where some types of diseases can be found by researches .

 

MEDICAL UTILITYStop and Go: ‘Traffic Officer’ Protein Directs Crucial Step in Cell Division

MEDICAL UTILITY

By knowing new cell cycle regulator molecules, the health team can find new targets for producing antibiotics and medicines for discover and prevent new diseases.

Stop and Go: ‘Traffic Officer’ Protein Directs Crucial Step in Cell Division

BIBLIOGRAPHY · Martinez S, Lina Maria. Biología Molecular.

5 ed Medellín: UPB. Fac Medicina

. Study sheds light on the aNews medical .(July 6, 2012)

 

· Stop and Go: ‘Traffic Officer’ Protein Directs Crucial Step in Cell Division. Science Daily. (July 6,2012)

  .

THANK YOU