Plants Producing

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    PLANTS PRODUCING:-

    1)LATHYRISM   2)THIAMINE

    DEFICICENCY   3)OXALATE

    POISIONING

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    LATHYRIUM

    • It is cri!i"# $is%&s% c&'s%$ ( %&ti"# !%#'*%s +, #%"'s Lathyrus (wild pea, common vetch)

    •  EPIDEMIOLOGY!

      s%%" i" I"$i&" s'(c+"ti"%"t Et.+i& R'ssi& E'r+% / N+rt. &*%ric&0

     *&i"! i" $r&'#.t c+"$iti+"s0

     hippocrates ("#$!%%& ') reported this

    •  2 t %s !&t. ri'* : Ost%+!&t. ris*

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    A0 O*+EOL+-Y.I/M

    • S%%" i" &"i*&!s c+"s'*i"# L0+$+r&t's s%%t %& ) L0'si!!i's / L0!&ti,+!i's

    •  c.&r&ct%ris%$ ( s0eletal de1ormities &"$

    aortic rupture •  !&t.r+#%"ic s'(t&"c%s is 'eta !2!( 3amma!l

    3lutamly)!aminopropionitrile ('P2 )

    •  T.is is !+c&!i%$ ri*&ri! i" %&4 s%%$ +, t.is

    !&"ts0 •  +"c% i"#%st%$ it *& (% c+"5%rt%$ i"t+ 'eta

    aminopropionitrile .ic. is &!s+ r%s+"si(!%0

    • It is .%&t !&(i!% 0

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    • 6APN %7%rts its t+7ic %8%cts (

      1) i".i(iti"# ,+r*&ti+" +, %!&stic 9(r%s i" t.% &!!s +, &rt%ri%s ( i"cr%&s%$ r+!i,%r&ti+" +,

    9(r+(!&ts0

      2) c&'si"# irr%#'!&riti%s i" s"t.%sis +, c+!!%" 9(r%s0

      c+!!%" cr+ss !i";i"#

    +7i$&ti5% $%&*i"&ti+" +, %ti$% (+'"$ !si"%

      LYSYL OXIDASE 6APN

      O7i$is%$ !si"% r%si$'%   &*i"+&ci$ +, &$ &c%"t

    MECHANISM

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    CLINICAL SINGS /  TREATMENT

    • L&*%"%ss +, .i"$ !%#s

    •  %7+st+s%s

     &i" i" ,%%t •  $isi"c!i"&ti+" t+ r&is%

      NO SPECIFIC R7 / it is s*t+*&tic

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    60 NEUROLATHYRISM

    •  A8%cti"# .'*&"s .+rs%s c&tt!% &ss+ci&t%$ it. !+"# t%r* =3*+"t.s ) ,%%$i"# +, s%%$s L0s&ti5's 

    L0cic%r&0

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    MECHANISM

    •  ODPA c&'s%s "%'r+"&! $&*% t+ *+t+r c%!!s +, t.+r&cic / !'*(&r si"&! "%r5%s t.r+'#. its %7cit&t+7ic

    &cti+" +" #!'t&*&t% r%c%t+r

    •  ODPA %7%rts its $ir%ct "%'r+t+7ic &cti+" / *& c&'s% ,r%% r&$ic&!

    $&*% t+ (r&i"0 • S**%tric&! &7+"&! $%#%"%r&ti+" +,

    (+t. cr+ss%$ &"$ '"cr+ss%$

    r&*i$&! tr&cts i" si"&! c+r$ 0

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    • C!0 Si#"s:-

    o  *'sc'!&r %&;"%ss

    o  s.i,ti"# +, %i#.t ,r+* +"% !%# t+ +t.%r

    o  &r&!sis +, !%# (!&$$%r r%ct'* /

    sti8"%ss o  $s"+%&

    •  PM FINDINGS:-

    o  C+*!%t% $%*%!i"&ti+" +, !&t%r&! .it% c+!'*"s +" (+t. si$%s i" si"&! c&r$0

    •  R7 :- s*t+*&tic

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    OSTEOLATHYRI

    SM

    NEUROLATHYRIS

    M  COMMON FORM *&i"!

    &8%cts c&tt!%

     L0+$+r&t's

    6APN S>ELETAL DEFORMITIES /

    AORTIC RUPTURE

     COMMON IN HUMANS HORSE /

    CATTLE ( !+"# t%r* =3*+"t.s)

    ,%%$i"#

    L0s&ti5's ODAP

    NEURONAL DAMAGE OF THORAIC

    / LUM6AR SPINAL NER?ES

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     THIAMINE DEFICIENCY

    •  6RAC>EN FERN POISONING

    •  ,%r"!&"ts :- pteridium a9ulinum(r&c;%" ,%r")

    • Ot.%r !i;% :- .+rs% t&i! r+c; ,%r"

    • It r+$'c%s t.i&*i"% $%9ci%"c i" *+"+#&stric &"i*&!s / 6@ $%!%ti+" i" r'*i"&"ts

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    MECHANISM

    I" To#i!it$ o %ra!&en 'ern ( Horse Tail : In non) ruminants

    I" citric &ci$ cc!% T.i&*i"% is r%B'ir%$ ,+rPr'5&t% Ac%t! C+-A ->%t+#!'t+r&t% S'cci"! C+-A

    I" t+7icit:  T.i&*i"&s %

    Pri*i$i"% T.i&+!%

    This !auses a*normal ener+$ meta*olism ,hi!h a-e!tsmainl$ CNS"

     T.i&*i"%

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    II" To#i!it$ o %ra!&en 'ern ( Horse Tail : In ruminants T.is is $'% t+ &!&stic &"%*i& ,&ct+r- /taquiloside

     C&'s%s $%&t. +, r%c'rs+r c%!!s i" 6M / &8%cts r+$'cti+" +, "%%r (!++$ c%!!s0

    C&tt!% &r% *+st s'sc%ti(!%)

    III" Tumour. hematuria or red ,ater disease

     T.is is $'% t+ !+"# t%r* c+"s'*ti+" +, 6r&c;%" F%r" c+"t&i"i"# c&rci"+#%"ic s'(st&"c%- Pt&B'i!+si$%0 C&tt!% &r% *+r% s'sc%ti(!% $'% t+ &!;&"i"% 'ri"%

    Pt&B'i!+si$ %

    Di%"+" %

    A!;!&t%s DNA !%&$i"# t+ t'*+'r

    H%*&t'ri&

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    CLINICAL SI0NS: HORSE: As 6r&c;%" st#%rs

    E*&ci&ti+" @%i#.t !+ss L%t.&r# St#%ri"# #&it U"st%&$"%ss

    R%c'*(%"c C+!ic H%*+#!+(i"'ri& D%&t. i" 2-1 $&s0

    PIG: L%ss $isti"ct si#"s R%s%*(!% .%&rt ,&i!'r%

    RUMINANTS: 6M $%r%ssi+"

    6!%%$i"# ,r+* +ri9c%s ..%*&) A"+r%7ic Pr%tic E$%*& +, t.r+&t r%#i+"

    Ds"+%& H%*&t'ri&  T'*+'rs- .%*&"#is&rc+*&9(r+*&

    SHEEP: 6ri#.t (!i"$"%ss A!%rt &ttit'$% H%*&t'ri&

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    HUMAN RIS2:

     R%#'!&r c+"s'*ti+" +, '"tr%&t%$ *i!; ,r+* c&tt!% it. &cc%ss t+ (r&c;%" ,%r"

    *& i"$'c% #&stric +r +%s+.%&! '!c%r0

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    O3ALATE /OISONIN0

    Occ'rs ( c+"s'*i"# +7&!&t% c+"t&i"i"# !&"ts0

    -alo3eton 3lomeratus &"$ O5alis pescaprae &r% t+ i*+rt&"t +7&!&t% r+$'ci"# !&"ts +, t.% +r!$0

    Ot.%r !&"ts:

    O&; E!%.&"t Gr&ss 

    S'#&r 6%%tPi# %%$ Gr%&s% @++$ 6&ssi&

    >+c.i&

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    PROPERTIES  O7&!&t%s +cc'r i" !&"ts ri*&ri! &s s&!ts +, c&!ci'* s+$i'*

    &**+"i'* +t&ssi'* &"$ *"%si'*0

    -alo3eton 3lomeratus c+"t&i"s3 +" DM (&sis) +7&!ic &ci$ HOOC-COOH) &s s+!'(!% s+$i'* &"$ +t&ssi'* +7&!&t%s 3- !%&5%s 1-s%%$s 3-st%*)0

    Asper+illus &" +7&!&t% r+$'ci"# ,'"#'s *& %!%5&t% +7&!&t% c+"t%"t i" *+'!$ ,%%$0

     T.% s+$i'* &"$ +t&ssi'* +7&!&t%s (%i"# s+!'(!% &r% ,r%% t+ (% &(s+r(%$ +r t+ r%&ct it. t.% c&!ci'* i" t.% G! tr&ct t+ ,+r*

    i"s+!'(!% s&!ts0

     T.% c&!ci'* &"$ *"%si'* +7&!&t%s &r% I"s+!'(!% s+ !%ss &(s+r(%$ ,r+* t.%

    GIT0

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    FACTORS AFFECTING TOXICITY: S%ci%s:

     T% +, !&"t

    F+r* +, +7&!&t% r%s%"t i" !&"t

    D'r&ti+" +, %7+s'r%

    HORSESHEEP CO@

    C+**+"! &8%ct%$ P&st'r% c+"t&i"i"# 2 s+!'(!% +7&!&t% i!! c&'s% $%&t.

    Ut+ # +, s+$i'* +7&!&t% #i5%" +r&!! r+$'c%s ,&t&! %8%ct

    C&" t+!%r&t% 't+ J# +, +7&!!ic &ci$ it.+'t .&r*,'!! %8%ct (%c&'s%

    r+$'c%s i"s!+'(!% C& +7&!&t% ,r+* ,r%% +7&!&t%

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    MECHANISM O' ACTION

    I0 O7&!&t% K S%r'* c&!ci'*  C&!ci'* +7&!&t%

    it $%!%t%s i+"is%$ c&!ci'*)

    HY/OCALCE MIA

    I"t%r,%rsit. %!%ctric&! &cti5it +, .%&rt *'sc!% /

    "%r5%

    I*&irs (!++$ c!+tti"# *%c.&"is *

    I"t%r,%rs it. *i!; r+$'cti+ " / (+"% #r+t.

    I*&irs "+r*&! c%!! *%*(r&" % ,'"cti+"

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    II" Insolu*le o#alate !r$stals produ!es dire!t e-e!t:

    D%+siti+" i" r%"&! t'('!%s c&'s%s +7&!&t%

    "%.r+sis

    O7&!&t%s #%t crst&!i% i" (r&i" tiss'%

    / c&'s%s &r&!sis / CNS $is+r$%rs

    Acc'*!&ti+ " i" r'*%" %it.%!i&! !i"i"# c&'s%s .%*+rr.% s

    D