Plants Producing

8/20/2019 Plants Producing

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PLANTS PRODUCING:-

1)LATHYRISM 2)THIAMINE

DEFICICENCY 3)OXALATE

POISIONING


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LATHYRIUM

• It is cri!i"# $is%&s% c&'s%$ (%&ti"# !%#'*%s +, #%"'s Lathyrus(wild pea, common vetch)

• EPIDEMIOLOGY!

s%%" i" I"$i&" s'(c+"ti"%"tEt.+i& R'ssi& E'r+% / N+rt.&*%ric&0

*&i"! i" $r&'#.t c+"$iti+"s0

hippocrates ("#$!%%& ') reportedthis

• 2 t %s !&t. ri'* : Ost%+!&t. ris*


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A0 O*+EOL+-Y.I/M

• S%%" i" &"i*&!s c+"s'*i"# L0+$+r&t's s%%t%& ) L0'si!!i's / L0!&ti,+!i's

• c.&r&ct%ris%$ ( s0eletal de1ormities &"$

aortic rupture• !&t.r+#%"ic s'(t&"c%s is 'eta !2!( 3amma!l

3lutamly)!aminopropionitrile ('P2 )

• T.is is !+c&!i%$ ri*&ri! i" %&4 s%%$ +, t.is

!&"ts0• +"c% i"#%st%$ it *& (% c+"5%rt%$ i"t+ 'eta

aminopropionitrile .ic. is &!s+ r%s+"si(!%0

• It is .%&t !&(i!% 0


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• 6APN %7%rts its t+7ic %8%cts (

1) i".i(iti"# ,+r*&ti+" +, %!&stic 9(r%s i" t.%&!!s +, &rt%ri%s ( i"cr%&s%$ r+!i,%r&ti+" +,

9(r+(!&ts0

2) c&'si"# irr%#'!&riti%s i" s"t.%sis +, c+!!%"9(r%s0

c+!!%" cr+ss !i";i"#

+7i$&ti5% $%&*i"&ti+" +, %ti$% (+'"$ !si"%

LYSYL OXIDASE 6APN

O7i$is%$ !si"% r%si$'% &*i"+&ci$ +, &$ &c%"t

MECHANISM


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CLINICAL SINGS / TREATMENT

• L&*%"%ss +, .i"$ !%#s

• %7+st+s%s

•

&i" i" ,%%t• $isi"c!i"&ti+" t+ r&is%

NO SPECIFIC R7 / it is s*t+*&tic


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60 NEUROLATHYRISM

• A8%cti"# .'*&"s .+rs%s c&tt!%&ss+ci&t%$ it. !+"# t%r* =3*+"t.s) ,%%$i"# +, s%%$s L0s&ti5's

L0cic%r&0


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MECHANISM

• ODPA c&'s%s "%'r+"&! $&*% t+*+t+r c%!!s +, t.+r&cic / !'*(&rsi"&! "%r5%s t.r+'#. its %7cit&t+7ic

&cti+" +" #!'t&*&t% r%c%t+r

• ODPA %7%rts its $ir%ct "%'r+t+7ic&cti+" / *& c&'s% ,r%% r&$ic&!

$&*% t+ (r&i"0• S**%tric&! &7+"&! $%#%"%r&ti+" +,

(+t. cr+ss%$ &"$ '"cr+ss%$

r&*i$&! tr&cts i" si"&! c+r$ 0


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• C!0 Si#"s:-

o *'sc'!&r %&;"%ss

o s.i,ti"# +, %i#.t ,r+* +"% !%# t++t.%r

o &r&!sis +, !%# (!&$$%r r%ct'* /

sti8"%sso $s"+%&

• PM FINDINGS:-

o C+*!%t% $%*%!i"&ti+" +, !&t%r&!.it% c+!'*"s +" (+t. si$%s i" si"&!c&r$0

• R7 :- s*t+*&tic


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OSTEOLATHYRI

SM

NEUROLATHYRIS

M COMMON FORM *&i"!

&8%cts c&tt!%

L0+$+r&t's

6APNS>ELETAL DEFORMITIES /

AORTIC RUPTURE

COMMON IN HUMANS HORSE /

CATTLE ( !+"# t%r* =3*+"t.s)

,%%$i"#

L0s&ti5'sODAP

NEURONAL DAMAGE OF THORAIC

/ LUM6AR SPINAL NER?ES


11/28

THIAMINE DEFICIENCY

• 6RAC>EN FERN POISONING

• ,%r"!&"ts :- pteridiuma9ulinum(r&c;%" ,%r")

• Ot.%r !i;% :- .+rs% t&i! r+c; ,%r"

• It r+$'c%s t.i&*i"% $%9ci%"c i"*+"+#&stric &"i*&!s / 6@ $%!%ti+"i" r'*i"&"ts


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13/28

MECHANISM

I" To#i!it$ o %ra!&en 'ern ( Horse Tail : In non)ruminants

I" citric &ci$ cc!% T.i&*i"% is r%B'ir%$ ,+rPr'5&t% Ac%t! C+-A->%t+#!'t+r&t% S'cci"! C+-A

I" t+7icit: T.i&*i"&s%

Pri*i$i"% T.i&+!%

This !auses a*normal ener+$ meta*olism ,hi!h a-e!tsmainl$ CNS"

T.i&*i"%


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II" To#i!it$ o %ra!&en 'ern ( Horse Tail :In ruminants T.is is $'% t+ &!&stic &"%*i& ,&ct+r- /taquiloside

C&'s%s $%&t. +, r%c'rs+r c%!!s i" 6M / &8%cts r+$'cti+" +,"%%r (!++$ c%!!s0

C&tt!% &r% *+st s'sc%ti(!%)

III" Tumour. hematuria or red ,ater disease

T.is is $'% t+ !+"# t%r* c+"s'*ti+" +, 6r&c;%" F%r" c+"t&i"i"#c&rci"+#%"ic s'(st&"c%- Pt&B'i!+si$%0C&tt!% &r% *+r% s'sc%ti(!% $'% t+ &!;&"i"% 'ri"%

Pt&B'i!+si$%

Di%"+"%

A!;!&t%s DNA!%&$i"# t+ t'*+'r

H%*&t'ri&


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CLINICAL SI0NS:HORSE:As 6r&c;%" st#%rs

E*&ci&ti+"@%i#.t !+ssL%t.&r#St#%ri"# #&itU"st%&$"%ss

R%c'*(%"cC+!icH%*+#!+(i"'ri&D%&t. i" 2-1 $&s0

PIG:L%ss $isti"ct si#"sR%s%*(!% .%&rt ,&i!'r%

RUMINANTS:6M $%r%ssi+"

6!%%$i"# ,r+* +ri9c%s..%*&)A"+r%7icPr%ticE$%*& +, t.r+&t r%#i+"

Ds"+%&H%*&t'ri& T'*+'rs-.%*&"#is&rc+*&9(r+*&

SHEEP:6ri#.t (!i"$"%ssA!%rt &ttit'$%H%*&t'ri&


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18/28

HUMAN RIS2:

R%#'!&r c+"s'*ti+" +, '"tr%&t%$ *i!;,r+* c&tt!% it. &cc%ss t+ (r&c;%" ,%r"

*& i"$'c% #&stric +r +%s+.%&!'!c%r0


19/28

O3ALATE /OISONIN0

Occ'rs ( c+"s'*i"# +7&!&t% c+"t&i"i"# !&"ts0

-alo3eton 3lomeratus &"$ O5alis pescaprae &r%t+ i*+rt&"t+7&!&t% r+$'ci"# !&"ts +, t.% +r!$0

Ot.%r !&"ts:

O&;E!%.&"t Gr&ss

S'#&r 6%%tPi# %%$Gr%&s% @++$6&ssi&

>+c.i&


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PROPERTIES O7&!&t%s +cc'r i" !&"ts ri*&ri! &s s&!ts +, c&!ci'* s+$i'*

&**+"i'* +t&ssi'* &"$ *"%si'*0

-alo3eton 3lomeratus c+"t&i"s3 +" DM (&sis) +7&!ic &ci$HOOC-COOH) &s s+!'(!% s+$i'* &"$ +t&ssi'* +7&!&t%s 3-!%&5%s 1-s%%$s 3-st%*)0

Asper+illus &" +7&!&t% r+$'ci"# ,'"#'s *& %!%5&t% +7&!&t%c+"t%"t i" *+'!$ ,%%$0

T.% s+$i'* &"$ +t&ssi'*+7&!&t%s (%i"# s+!'(!% &r% ,r%% t+(% &(s+r(%$ +r t+ r%&ct it. t.%c&!ci'* i" t.% G! tr&ct t+ ,+r*

i"s+!'(!% s&!ts0

T.% c&!ci'* &"$*"%si'*+7&!&t%s &r% I"s+!'(!% s+!%ss &(s+r(%$ ,r+* t.%

GIT0


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FACTORS AFFECTING TOXICITY:S%ci%s:

T% +, !&"t

F+r* +, +7&!&t% r%s%"t i" !&"t

D'r&ti+" +, %7+s'r%

HORSESHEEP CO@

C+**+"! &8%ct%$P&st'r% c+"t&i"i"#2 s+!'(!% +7&!&t%i!! c&'s% $%&t.

Ut+ # +,s+$i'* +7&!&t%#i5%" +r&!!r+$'c%s ,&t&!%8%ct

C&" t+!%r&t%'t+ J# +,+7&!!ic &ci$it.+'t.&r*,'!! %8%ct(%c&'s%

r+$'c%si"s!+'(!% C&+7&!&t% ,r+*,r%% +7&!&t%


22/28

MECHANISM O' ACTION

I0 O7&!&t% K S%r'* c&!ci'* C&!ci'*+7&!&t%

it $%!%t%s i+"is%$ c&!ci'*)

HY/OCALCEMIA

I"t%r,%rsit.%!%ctric&!&cti5it +,.%&rt*'sc!% /

"%r5%

I*&irs(!++$c!+tti"#*%c.&"is*

I"t%r,%rsit. *i!;r+$'cti+" / (+"%#r+t.

I*&irs"+r*&!c%!!*%*(r&"% ,'"cti+"


23/28

II" Insolu*le o#alate !r$stals produ!es dire!te-e!t:

D%+siti+"i" r%"&!t'('!%sc&'s%s+7&!&t%

"%.r+sis

O7&!&t%s#%tcrst&!i% i"(r&i" tiss'%

/ c&'s%s&r&!sis /CNS$is+r$%rs

Acc'*!&ti+" i" r'*%"%it.%!i&!!i"i"#c&'s%s.%*+rr.%s

D%+siti+" /crst&!i&ti+"c&'si"# $&*%i" (!++$ 5%ss%!s

III" Intereren!e ,ith !ellulose di+estion:

I" s.%% +7&!&t%s &r% r%&$i! $%t+7i9%$ i" r'*%" / c+"5%rt%$ t+c&r(+"&t% &"$ (ic&r(+"&t% .ic. *& r+$'c% s%5%r% &!;&!+sis0

I4" O#ali! a!id is !orrosi5e


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CLINICAL SI0NS

ACUTE /OISONIN0:

O7&!&t% i"$'c%$.+c&!c%*i& r%s'!ts i":S&!i5&ti+"I"c++r$i"&ti+" Titc.i"# +, *'sc!% T%t&"M$ri&sisC+*&D%&t.

R%"&! t'('!&r "%cr+sis r%s'!ts

i":A+t&%*i&H%r;&!%*i&C&r$i&c ,&i!'r%O!i+#'ri&

SU%ACUTE /OISONIN0:

Sti8 #&itR%c'*(%"cR%$ (r+" c+!+'r 'ri"%

CHRONIC /OISONIN0:Ur%*i&A!('*i"'ri&H%*&t'ri&


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/M 'IN1IN0S

E$%*& / .%*+rr.%s +, r'*%" &!! i" r'*i"&"ts

GIT i" si"%0

>i$"% *& (% %$%*&t+'s / $&r; i" c+!+'r0

C&!ic'!i ,+'"$ i" 'r%t.r&! r+c%ss / si#*+i$ %7'r%+, ('!! / r&*0

?&ri+'s tiss'% *& s.+ c&"+sis0

1IA0NOSIS:

PC? $%cr%&s%s6UN / (!++$ > K i"cr%&s%s0


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TREATMENT :

N+t s%ci9c +"! s'+rti5% t.%r&0

C& s&!t- C& (+r+#!'c+"&t%2 s+!") 3-*! I?

A$*i"istr&ti+" +, !i*% &t%r t+ r%5%"t ,'rt.%r&(s+rti+" +, s+!'(!% +7&!&t%0


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LATHYRISM

Ost%+!&t.ris*

L0+$+r&t's

N%'r+!&t.ris* L0s&ti5's

6APN

ODAP

6RAC>ENFERN

Pt%ri$i'*

&B'i!i"'*

T.i&*i"&

s%

H+rs% t&i!Pt&B'i!+si

$%

'%rc%ti"

O7&!&t%+is+"i"

#

H&!+#%t+"

O7&!is

S+!'(!% N&/ > +7&!&t%

I"S+!'(!%c& / *#

+7&!&t%


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Plants Producing

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