Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the...

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07/05/2022 Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus Susan Fisher, Ph.D.

Transcript of Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the...

Page 1: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

05/01/2023

Placental and Decidual Expression of Zika Virus Receptors: The Route to

Infection of the Embryo/Fetus

Susan Fisher, Ph.D.

Page 2: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

05/01/2023

The Maternal-Fetal Interface in Human Pregnancy

Preparedness for the Zika Virus: A Public Health Emergency

Romero R., Dey SK, Fisher SJ. (2014) Science. 345:760-5

Page 3: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

05/01/2023Preparedness for the Zika Virus: A Public Health Emergency

Anatomy of the human maternal-fetal interface.

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05/01/2023

Different Zika Virus Receptors* Are Expressed inDifferent Extraembryonic Compartments (RNA-seq)

Preparedness for the Zika Virus: A Public Health Emergency

**Hamel et al., Biology of Zika Virus Infection in Human Skin Cells. J Virol. 2015.

Page 5: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

05/01/2023

Different Zika Virus Receptors Are Expressed inDifferent Trophoblast Subpopulations (Laser

Capture Microdissection/Microarray)

Preparedness for the Zika Virus: A Public Health Emergency

Page 6: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

1st Trimester Floating Villi: Syncytiotrophoblasts and Cytotrophoblasts Express Zika Virus Receptors

Preparedness for the Zika Virus: A Public Health Emergency 05/01/2023

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1st Trimester Anchoring Villi: Invading Cytotrophoblasts Express Zika Virus Receptors

Preparedness for the Zika Virus: A Public Health Emergency 3/6/2016

Page 8: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

2nd trimester Trimester Floating Villi: Syncytiotrophoblasts Express Zika Virus Receptors

Preparedness for the Zika Virus: A Public Health Emergency 3/6/2016

Page 9: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

2nd Trimester Anchoring Villi: Invading Cytotrophoblasts Express Zika Virus Receptors

Preparedness for the Zika Virus: A Public Health Emergency 3/6/2016

Page 10: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

2nd Trimester Fetal Membranes: Decidua and Some Chorionic Cytotrophoblasts Express AXL

Preparedness for the Zika Virus: A Public Health Emergency 3/6/2016

Page 11: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

2nd Trimester Fetal Membranes: Some Chorionic Cytotrophoblasts and All Amniocytes Express AXL

Preparedness for the Zika Virus: A Public Health Emergency 3/6/2016

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The Decidua, But Not The Fetal Membranes, Expresses CD209.

Preparedness for the Zika Virus: A Public Health Emergency 3/6/2016

Page 13: Placental and Decidual Expression of Zika Virus Receptors: The Route to Infection of the Embryo/Fetus

05/01/2023Preparedness for the Zika Virus: A Public Health Emergency

Red Arrows: Proposed Routes by Which Zika Virus Infection Reaches the Embryo/Fetus

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