Physiology of Aging - Dr Williams
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Author: Brent C. Williams, M.D., M.P.H., 2009
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Spring 2009M1 Human Growth & Development 3
Physiology of Aging
Brent C. Williams, MD, MPH
Associate Professor of Medicine
University of Michigan
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4
Intended Learning Outcomes
Distinguish usual from successful aging. Describe the major age-associated changes in
human physiology. Understand the “anti-aging” effects of
exercise. Be able to assess nutritional status of older
adults, including risks from medications. Appreciate the importance of functional
assessment of older individuals.
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5
What is Aging?
Ed from Ohio, flickr
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Aging
is not a diseaseoccurs at different rates
•among individuals
•within individuals
does not generally cause symptoms
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Characteristics of Mammalian Aging
cellular and physiologic deteriorationincreased mortality with age
following maturationincreased vulnerability to diseasedecreased ability to adapt to stress
• impaired homeostasis
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“Normal” Aging as:
Optimal – Best example or idealizedUsual - most commonUniversal – seen in all humansAll are influenced by:
• Genetics - Lifestyle
• Physiology - Socioeconomics
8
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Problems with Normal Aging
heterogeniety
normal does not imply without risk
normal does not imply natural
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Aging
Disease Non-disease
Usual Successful
Rowe & Kahn, Science 237:143, 1987
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From Usual to Successful Aging – Clinical Approach
Normalizing - Helps patients understand what to expect
• Adjust to likely changes (e.g., sleep/wake, bowels, balance, benign forgetfulness)
• Identify potential symptoms of disease (sleep apnea, depression; hypothyroidism; gait disorder; cognitive impairment)
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Usual to Successful Aging for Clinicians (cont’d)
Maintain or improve modifiable causes of age-related change
• Exposures (UV radiation, noise)
• Psychological well-being (social isolation)
• Cognition (mental inactivity)
• Nutrition (cholesterol, sodium, calcium)
• Exercise (fitness, strength, balance)
12
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Most people live nowhere near their limits. They settle for an accelerated aging, and early
and precipitous fall. They give aging a bad name.
George Sheehan, M.D.
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14
Intended Learning Outcomes
Distinguish usual from successful aging. Describe the major age-associated changes in
human physiology. Understand the “anti-aging” effects of
exercise. Be able to assess nutritional status of older
adults, including risks from medications. Appreciate the importance of functional
assessment of older individuals.
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15
What is normal (clinically expected) aging physiology?
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Aging Physiology
Source Undetermined
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Overview of Aging Physiology
SkinBody
CompositionVisionSpecial SensesNervous System
Musculoskeletal System
RenalGICardiovascular
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Aging Skin
Source Undetermined
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Source Undetermined
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Aging and Central Adiposity
Source Undetermined
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Source Undetermined
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Source Undetermined
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Age-Associated Factors - Vision
visual acuity (cataracts, macular degeneration)
dark adaptationperipheral vision
(glaucoma)contrast sensitivityaccommodation
Source Undetermined
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Age-Associated Factors-Special Senses
Auditory and Vestibular• Presbycusis: high frequency hearing loss
• Vestibular dysfunctionSmellOral/Dental• Teeth: 40% of elderly are edentulous
• Taste
• Salivary functionPearson Scott Foresman, wikimedia commons
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Age-Associated Factors-Nervous System
CNS: decrease in nerve cell number
basal ganglia atrophy dopamine and muscular
rigidity step height reaction time PNS: decreased vibratory
sensationGray’s Anatomy, wikimedia commons
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Age-associated Factors: Musculoskeletal system
30% loss in muscle mass 3rd to 8th decade - sarcopenia.
Osteoarthritis• weight bearing (spine/knees/1st metatarsophalangeals)• repeated strain (distal interphalanges/1st carpometacarpals)
Osteopenia/-porosis (80% women >65 y/o osteopenia)• decreased activity, dietary calcium, estrogen withdrawal
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Aging Renal Physiology
GFR 30-46%
Tubular function
Renal plasma flow ~50%
CrCl = [(140 - age) x (BW)]/[72 x SrCr ]
• Multiply x 0.85 for females
• BW in kg (LBW or IBW with edema or obesity)
Gray’s Anatomy, wikimedia commons
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Absorption: GI Physiology
GI absorptive cells GI motility or normal
Sphincter activity GI blood flow Gastric acid secretion Active transport
Source Undetermined
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Wikimedia commons
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Afterload: Vascular Changes
Vascular Smooth Muscle
• Increased thickness of intima and media
•Matrix» Collagen deposition, increased fibronectin,
crosslinking (AGEs)» Fragmentation of elastin, calcium deposition
Net result is increased vascular stiffness.
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Summary: Age-associated changes in cardiovascular physiology
Maintenance of resting left ventricular function.
Decreased ability to compensate for stress or impaired LV function.
•Blunted heart rate response to exercise requires a compensatory increase in stroke volume to increase cardiac output.
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Effect of Aging & CAD on Exercise LV Ejection Fraction
Fleg et al., J App Physiol, 1993
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Aging and
Aerobic Capacity
Source Undetermined
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2:00:00
2:37:30
3:15:00
3:52:30
4:30:00
5:07:30
5:45:00
6:22:30
7:00:00
20 30 40 50 60 70 80 90 100Age (years)
Mar
atho
n T
ime
Source Undetermined
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"I don't know if I'll do it next year. ... But wait until I hit that magic 95-year-old age group."
John Besson, Jr., after finishing the 2002 Portland Marathon, and lowering the 90+ U.S. best from 7:25 to 6:48
2:00:00
2:37:30
3:15:00
3:52:30
4:30:00
5:07:30
5:45:00
6:22:30
7:00:00
20 30 40 50 60 70 80 90 100Age (years)
Source Undetermined
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36
Intended Learning Outcomes
Distinguish usual from successful aging. Describe the major age-associated changes in
human physiology. Understand the “anti-aging” effects of
exercise. Be able to assess nutritional status of older
adults, including risks from medications. Appreciate the importance of functional
assessment of older individuals.
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37Source: Vita et al., NEJM 338:1035, 1998
Aging, Health Risks and Cumulative Disability
Longitudinal study of 1741 U Penn alumni Health Risk in 1962 (age mean 43 yrs.)
determined from BMI, smoking, and exercise; low, moderate, high
Disability index determined in 1986: 100% greater in high than low risk group (1.02 vs, 0.49; P<0.001)
Progression in disability postponed by 7 years.
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Vita et al., NEJM 338:1035, 1998
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39
True or False?
Older people should stop exercising and rest.
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Rather than seeking permission to
exercise, you should have to get
permission to be sedentary.
Maria Fiatarone, M.D.
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PhysiologicCharacteristic
Aging Exercise
Fat mass Bone mineral density VO2 max Muscle strength Glucose tolerance Insulin sensitivity Cholesterol
Aging: A state of chronic exercise deficiency?Only 29% of elderly report any regular exercise.
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Benefits of Exercise
Weight loss• Decrease central adiposity
• Increase lean body mass Blood pressure decline Aerobic capacity increase Insulin sensitivity increase Increase bone mass Increase muscle strength Increase perceived well being
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43
Source Undetermined
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Source Undetermined
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Intended Learning Outcomes
Distinguish usual from successful aging. Describe the major age-associated changes in
human physiology. Understand the “anti-aging” effects of
exercise. Be able to assess nutritional status of older
adults, including risks from medications. Appreciate the importance of functional
assessment of older individuals.
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Protein-Calorie Malnutrition Among Older Persons
5-12% in community
30-61% hospitalized
40-85% in long-term care facilities.
46
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Inadequate Nutrition Among Older Individuals
Increases severity of disease Increases possibility of physical
limitations due to decreased musculature Decreases functional status Can increase drug effects due to changed
metabolism and/or weight loss
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Importance of Nutrition for Older Adults
Older Adults are at increased risk of inadequate diet from:• Diseases - acute/chronic
» half of hospitalized older patients are malnourished.half of hospitalized older patients are malnourished.
• Physical limitations
• Inability to chew and poor oral health
• Social isolation/depression/low income
• Impaired functional status
• Alcohol use and abuse
• Drug - nutrient Interactions
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Causes of Malnutrition
Medications Oral factors Wandering (dementia) Emotional probs Neoplasia Hyperthyroidism etc Anorexia Enteric problems
Late-life paranoia Eating problems Swallowing disorders Low-salt /chol
Social problems
Source: Morley Ann Int Med 1995;123:850-859
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Assessing Nutritional Status Screening tools (e.g. DETERMINE; Mini-Nutritional
Assessment) to identify patients at risk.
Anthropometric data
• BMI, percent weight change
• Changes in body composition
Albumin, cholesterol
Vitamin levels - 25-OH-D3, B12
Involuntary weight loss > 10% (high specificity)
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Food Check List
Activities of Daily Living• What are they able to do?
Food intake• Food preparation capability or food provided
•What is being consumed?»Total amount of foodTotal amount of food»Types of food (fruits, vegs, protein foods, Types of food (fruits, vegs, protein foods,
grains)grains)»Fluids: Water especiallyFluids: Water especially
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Medication Check List
Number of medications Possible nutrient-drug interactions Vitamin B12 status (B12 is less absorbed with
increasing age due to less intrinsic factor being produced in the stomach)
Vitamin D status (low milk intake, no sunshine)
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How Drugs Affect Nutritional Status
Approximately 34 million Americans are 65 years or older yet they consume 30% of all medications.• Average patient taking 3 to 7 medications at one time.
Medications alter food intake, absorption, metabolism and excretion of nutrients.
Decreases in appetite, taste and smell. May cause GI disturbances such as nausea,
constipation, and/or diarrhea.
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Dietary Recommendations for Older Individuals
Adequate protein (1.0 gm/kg rather than 0.8).Ample fruits and vegetables for nutrients and
to avoid constipation.Optimal Calcium intake for men and women >
age 65: 1500 mg dailyWhole grain products (nutrient density and
fiber).Ample fluids, especially water.
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Intended Learning Outcomes
Distinguish usual from successful aging. Describe the major age-associated changes in
human physiology. Understand the “anti-aging” effects of
exercise. Be able to assess nutritional status of older
adults, including risks from medications. Appreciate the importance of functional
assessment of older individuals.
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True or False?
The majority of older people are self sufficient.
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Katz Activities of Daily Living (ADL) Scale
Definition: Things you needed to be able to do to go to kindergarten.
Components• Bathing• Dressing• Toileting• Transfer• Grooming• Feeding
Rated by level of assistance requiredIndependent, needs some assistance, unable
to perform task
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Instrumental Activities of Daily Living
Definition: Things you needed to do for yourself when you went off to college.
Grocery Shopping Meal preparation Driving or using public transportation Taking medications Laundry Using telephone Managing finances Housework
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Instrumental Activities of Daily Living
Definition: Things you needed to do for yourself when you went off to college.
Grocery ShoppingGrocery Shopping Meal preparationMeal preparation Driving Driving or using public transportation Taking medications Taking medications Laundry Using telephone Managing finances Housework
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ADL/ IADL Limitations
National Health Interview Survey, 1999 data. CDC. NCHS.
> age 65 65-74 years > age 750
10
20 ADL Limitation
IADL Limitation
Per
cen
tag
eP
erce
nta
ge
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Self-rated Health
01020304050
60708090
100
Poor or Fair Good
Age < 65Age > 65
Source Undetermined
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Intended Learning Outcomes
Distinguish usual from successful aging. Describe the major age-associated changes in
human physiology. Understand the “anti-aging” effects of
exercise. Be able to assess nutritional status of older
adults, including risks from medications. Appreciate the importance of functional
assessment of older individuals.
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Additional Source Information
for more information see: http://open.umich.edu/wiki/CitationPolicy
Slide 5: Ed from Ohio, flickr, http://www.flickr.com/photos/ed_aisela/206151319/, CC:BY-NC-SA, http://creativecommons.org/licenses/by-nc-sa/2.0/deed.enSlide 10: Rowe and Kahn, Science 237:143, 1987Slide 16: Source UndeterminedSlide 18: Source UndeterminedSlide 19: Source UndeterminedSlide 20: Source UndeterminedSlide 21: Source UndeterminedSlide 22: Source UndeterminedSlide 23: Source UndeterminedSlide 24: Pearson Scott Foresman, Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Ear_4_%28PSF%29.png Slide 25: Gray’s Anatomy, Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Gray715.png Slide 27: Gray’s Anatomy, Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Gray1127.png Slide 28: Source UndeterminedSlide 29: Wikimedia Commons, http://commons.wikimedia.org/wiki/File:Illu_artery.jpg Slide 32: Fleg et al., J App Physiol, 1993Slide 33: Source UndeterminedSlide 34: Source UndeterminedSlide 35: Source UndeterminedSlide 38: Vita et al., NEJM 338:1035, 1998Slide 43: Source UndeterminedSlide 44: Source UndeterminedSlide 60: National Health Interview Survey, 1999 data. CDC. NCHS.Slide 61: Source Undetermined