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Physics, Astrophysics and Applied Physics PhD School Metabolic radiotherapy Study and optimization...
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Transcript of Physics, Astrophysics and Applied Physics PhD School Metabolic radiotherapy Study and optimization...
Physics, Astrophysics and Applied Physics PhD School
Metabolic radiotherapy
Study and optimization of the production of relevant radionuclides
Simone ManentiR10548-R17
Thuesday, November 18, 2014
Physics, Astrophysics and Applied Physics PhD School
Physics, Astrophysics and Applied Physics PhD school
Applied Physics
Physics for Biomedicine
Physics, Astrophysics and Applied Physics PhD School
Image from http://hyperphysics.phy-astr.gsu.edu/
Physics, Astrophysics and Applied Physics PhD School
Available from: http://www.ncbi.nlm.nih.gov/books/NBK11464/
Physics, Astrophysics and Applied Physics PhD School
Image from: “The Opensource Handbook of Nanoscience and Nanotechnology”
Theranostics:therapy and diagnostics
Physics, Astrophysics and Applied Physics PhD School
Radiochim. Acta, 70-71, Pages 249–272
Characteristics of eligible radionuclides
• half life: few hours (~6) to days (~10)
• a suitable linear energy transfer (LET) value and range in the tissue
• a γ-emission that lays in an energy region suitable for the imaging
• high specific radioactivity (As)“specific activity” is defined as the amount
of radioactivity of the radionuclide of interest per unit mass of all the isotopes
of the radionuclide itself
Physics, Astrophysics and Applied Physics PhD School
M A IN S TE P S
R ad ion u c lid icP u rity
irrad ia tion con d it ion sop tim isa tion
th ick -ta rg e tyie ld s
th in -ta rg e texc ita tion fu n c tion s
N u c lear R eac tionS tu d ies
u ltra -h ig hp u rity eq u ip m en ts
U ltra -h ig hp u rity ta rg e ts
U ltra -h ig hp u rity ch em ica ls
N .C .A .rad ioch em ica l
p rocess in g
C h em ica lP u rity
S p ec ificA c tivity
R ad ioch em ica lP u rity
R ad ion u c lid icP u rity
Q u a lityC on tro l
N.C.A.Labelledcompound
Physics, Astrophysics and Applied Physics PhD School
Experimental procedure
Physics, Astrophysics and Applied Physics PhD School
X-ray and Auger electron emitter: 103Pd
103Pd(d,2n)103Pd
t1/2=16.991 d
electron capture=100%
Eγ=357.45 keV Iγ=0.0221%
Positron, X-ray and Auger electron emitter: 89Zr
89Y(d,2n)89Zr 89Y(p,n)89Zr
t1/2= 78.4 h
electron capture=76.6%
β+=22.3% Emax(β+)=897 keV Eave.(β+)=396.9 keV
Eγ=908.97 keV Iγ=100%
DIGITARE NOME CENTRO
DIGITARE NOME CENTRO
Physics, Astrophysics and Applied Physics PhD School
Thank you for your attention
Grazie per l’attenzione