Photograph of a Zmpste24−/− mouse, illustrating a characteristic dragging of the hind limb.

Bergo M O et al. PNAS 2002;99:13049-13054

©2002 by National Academy of Sciences

Growth rates and grip strength in mice.

Fong L G et al. PNAS 2004;101:18111-18116

©2004 by National Academy of Sciences

Western blots of extracts from wild-type, Zmpste24–/–, and Zmpste24–/–Lmna+/– MEFs with a carboxyl (C)-terminal prelamin A antibody and an amino (N)-terminal lamin A/C antibody.

Fong L G et al. PNAS 2004;101:18111-18116

©2004 by National Academy of Sciences

Nature 423, 298-301 (15 May 2003) | doi:10.1038/nature01631; Received 10 February 2003; Accepted 8 April 2003