Pharmanex

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CordyMax Cs-4:Dietary Supplement

CordyMax Cs-4 is an all-natural supplement that promotes vitality and stamina without the use of stimulants. CordyMax Cs-4 promotes the efficient use of oxygen and increases the body’s resistance to daily environmental stresses.

Vitality and Stamina.

CordyMax Cs-4: What is it?• CordyMax Cs-4 is an all natural supplement that

promotes vitality and stamina without the use of stimulants.

• CordyMax Cs-4 is a proprietary natural fermented product derived from fresh, natural Cordyceps sinensis, a mushroom from Qinghai Province in China.

• Cordyceps sinensis is a blade shaped mushroom that grows primarily in the Tibetan plateau at altitudes above 14,000 feet.

CordyMax Cs-4: Benefits

• Promotes vitality and stamina in all essential body organs

• Reduces fatigue

• Promotes healthy lung function

• Improves liver and kidney functions

• Positive benefit for sexual health

• Support of 30 clinical studies

CordyMax Cs-4: Advantage• Unique fermentation process• Standardised

– HPLC to guarantee potency and consistent results by supplying minimum levels of 0.14% adenosine

• Clinically and scientifically proven– 15 years of research; over 30 clinical studies– Contains no stimulants, reduce fatigue, increase energy– Not dependent on anecdotal data for efficacy

• Studies support resistance to free radical attack– Superoxide Dismutase– Mitochondria

CordyMax Cs-4: Advantage

• Pharmanex’s exclusive CordyMax Cs-4 formula is recognised in China as the fermented Cordyceps mushroom product offering health benefits most comparable to the rare and protected wild mushroom of the Tibetan high plateau.

• CordyMax Cs-4 has been placed under intellectual property protection, and only Pharmanex has an exclusive license outside of China.

CordyMax Cs-4: Clinical Studies

Health Benefit No. of studiesRespiratory 20Sexual function 5Cardiovascular function 4Free radical scavenging 4Kidney function 3Immune function 2Liver function 1Anti-fatigue 2

Recent data:Improved bioenergy status in animals (JACM 2001;7:231-240)Elevated VO2max in frail elderly subjects (MSSE 1999;31:S174)Enhanced exercise performance in athletes (MSSE 2001;33:S164)

CordyMax Cs-4: Clinical Studies• Abstracts• Supplementation with Cordyceps Cs-4

fermentation product promotes fat metabolism during prolonged exercise.

• Increased aerobic capacity in healthy elderly humans given a fermentation roduct of Cordyceps Cs-4.

• CordyMax Cs-4 enhances endurance in sedentary individuals.

CordyMax Cs-4: Clinical Studies

• Pharmanex Web Site - http://www.pharmanex.com.au/au/au/product/clinical_studies_references.shtml

• PubMed Web Site - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

JACM 2001;7:231-240

0

1

2

3

4

5

6

Placebo Cs-4 (200mg/kg/d) Cs-4 (400mg/kg/d)

Hepatic B-ATPB-ATP/Pi

31P

NM

R s

pect

rosc

ope

(w/M

DP

A r

ef)

•Male C57-BL/6 mice (n=5-6/group)•Treatment by gavage for 7days

•Hepatic ATP levels and inorganic phosphate by 13P NMR•B-ATP and B-ATP/Pi ratio increased in both Cs-4 groups (p<0.001)

•“Cs-4 increased hepatic energy state”

*

* = P<0.001

*

MSSE 1999;31:S174

+9%

CordyMax Cs-4

Placebo

0%

Imp

roved

Aero

bic

Cap

acit

y

(VO

2 m

ax)

•30 healthy, elderly Chinese subjects•Randomized to Cs-4 (3g/d/6wk) or placebo

•Incremental work rate cycle ergo meter protocol•Increased VO2max 1.88+0.13 to 2.00+0.14 (p<0.05)

“Cs-4 has potential for improving exercise capacity and resistance to fatigue”

MSSE 2001;33:S164

-15

-10

-5

0

5

10

15

Placebo Cs-4

HRO2 PulseRERLA

Perc

ent c

hang

e fr

om b

asel

ine

NSNSNS

NS

P=0.056

P=0.058

P<0.05

P<0.05

•30 highly trained male endurance athletes•Baseline VO2max = 62.6+7.7 ml/kg/min

•Cs-4 (4.5g/d/6wk) or placebo•60 min sub maximal performance test at 70% VO2max

“Cs-4 has positive circulatory and metabolic effects and may enhance fat mobilization and beta-oxidation during prolonged exercise”

CordyMax Cs-4:Enhances Endurance in Sedentary Individuals

Pharmanex data demonstrates that healthy sedentary adults consuming

CordyMax Cs-4 for 12 weeks can:

(1) Increase oxygen consumption (+5% in VO2peak)

(2) Enhance fat metabolism (-2% in RER)

(3) Improve exercise performance (-20 sec in 1-mile walk)

(+3% work output on bike test)

This confirms previous findings in animals, frail elderly and elite athletes,

showing a metabolic effect of Cs-4 supplementation to favourably influence oxygen consumption, energy metabolism and endurance performance.

CordyMax Cs-4: RecommendedAdult Usage

• For persons with busy, stressful and/or hectic lifestyles; athletes and the elderly, those desiring increased stamina.

• Take 2 capsules 2 to 3 times daily with food and drink.

• Women who are pregnant or are lactating, and people with know medical conditions, should consult a physician prior to taking supplements. Keep out of reach of children.

CordyMax Cs-4: Q&A• Who should take CordyMax Cs-4?• As a food supplement for use by individuals with busy, hectic lifestyles,

athletes and the elderly, and those desiring increased vitality without the use of stimulants.

• How are the ingredients in CordyMax Cs-4 standardised?• Each 525 mg capsule of proprietary CordyMax Cs-4 is standardised by

HPLC to guarantee potency and consistent results by supplying minimum levels of 0.14% adenosine. An additional test method is used to standardise to less than 6% mannitol, which is an indicator of polysaccharide content.

• If I’m taking CordyMax Cs-4, do I need to take OverDrive?• CordyMax Cs-4 is a daily supplement for your daily stamina and vitality.

OverDrive is focused more for the athlete. Even if you are not an athlete but have a busy and hectic lifestyle, CordyMax Cs-4 and OverDrive taken together is a great combination.

CordyMax Cs-4: Marketing Material

• Pharmanex Brochure (5 pk)$8.00

• Pharmanex Cap (ea)$12.95

• Power of Wisdom & Knowledge Video (ea)$7.50

• Pharmanex Pill Box (ea)$3.00

• CordyMax Cs-4 Brochure (5 pk)$4.50

CordyMax Cs-4: Summary

• Capsules

• Vitality and Stamina– Increased VO2 max– Healthy lung function & capacity

• Cordyceps sinensis proprietary ingredient

• Standardised

• Over 30 clinical studies