Pharmacology of South American freshwater stingray venom (Potamotrygon motoro): Rodrigues, R. F....

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Toxlcon, 1974, Vo( . 12, pp. 89 . PerQemon Press . Printed in Great Britain rt r~ V~ r " WS Rt~alauss, R . F . (Department of Pharmacology, University of SRo Paulo, S$o Paulo, Brazil) . Pharmarnlogy of South American freshwater stingray venom (Potmnotrygon niotoro) . 7Yans . N .Y . Acad . Sci . 34, 677, 1972. BlotoalcAl.r.Y active extracts were obtained from stings of the freshwater stingray Potamotrygon nrotoro, collected from the Aragusia Rives in Central Brazil . Active fractions were found in aqueous extracts of dried stings, and the aqueous fraction obtained from the dried atxtone extracts of fresh stings (the activity in the latter fraction was insoluble in petroleum bane) . At~ive fractions caused t~ntni<ctiona of guiltea pig ileum which were blocked by atropine but not by pyrilamine meleate or hexamethonium . Fractions active on guinea pig ileum produced hypotension (which was inhibited by previous administration of atropine) in rats . Incubation of some active fractions with chynwtrypsin did not affect activity, and boiling of several fractions for one minute as pH 7 did not affect the activity of two extracts but did decrease the activity of one fraction . P.R.S . Elvrmt, F. (Buroau ofVector Control and Solid Waste Management, California State Depart- ment of Public Health). A short review of scorpion biology, management of stings, and control . Calj/: Vector Yaws 19, 69, 1972 . Tms axt~,t .Erlz article aummatizes the general biology of scorpions, giving particular attetltion to American species, and to problems relating to their habitat and control, to the prevention of stings and the manage- ment of poisoning by these animals. In this reviewer's opinion, this is the most informative, wncise and well-written short dotalment on this subject that her yet appeared in many years . The paper should be in the ßles of every public health o1$cial or physician interested in the problem of scorpion envenomation, and it will be of equal interest to ell biologists working with arthropods . i10XICON 197~ Yo7. t1 89 F .E.R .

Transcript of Pharmacology of South American freshwater stingray venom (Potamotrygon motoro): Rodrigues, R. F....

Toxlcon, 1974, Vo(. 12, pp. 89 . PerQemon Press. Printed in Great Britain

rt r~V~r"WS

Rt~alauss, R. F. (Department ofPharmacology, University ofSRo Paulo, S$o Paulo, Brazil) .Pharmarnlogy of South American freshwater stingray venom (Potmnotrygon niotoro) . 7Yans.

N.Y. Acad. Sci. 34, 677, 1972.

BlotoalcAl.r.Y active extracts were obtained from stings of the freshwater stingray Potamotrygon nrotoro,collected from the Aragusia Rives in Central Brazil . Active fractions were found in aqueous extracts ofdried stings, and the aqueous fraction obtained from the dried atxtone extracts of fresh stings (the activityin the latter fraction was insoluble in petroleum bane).

At~ive fractions caused t~ntni<ctiona of guiltea pig ileum which were blocked by atropine but not bypyrilamine meleate or hexamethonium. Fractions active on guinea pig ileum produced hypotension (whichwas inhibited by previous administration of atropine) in rats . Incubation of some active fractions withchynwtrypsin did not affect activity, and boiling of several fractions for one minute as pH 7 did not affectthe activity of two extracts but did decrease the activity of one fraction .

P.R.S .

Elvrmt, F. (Buroau ofVector Control and Solid Waste Management, California State Depart-ment of Public Health). A short review of scorpion biology, management of stings, and

control. Calj/: Vector Yaws 19, 69, 1972 .

Tms axt~,t .Erlz article aummatizes the general biology of scorpions, giving particular attetltion to Americanspecies, and to problems relating to their habitat and control, to the prevention of stings and the manage-ment ofpoisoning by these animals.In this reviewer's opinion, this is the most informative, wncise and well-written short dotalment on this

subject that her yet appeared in many years. The paper should be in the ßles of every public health o1$cialor physician interested in the problem of scorpion envenomation, and it will be of equal interest to ellbiologists working with arthropods .

i10XICON 197~ Yo7. t189

F.E.R .