Pharmaceutica ' l - GBV11.50-12.20 DEVELOPMENT AND IN VITRO EVALUATION OF NIMOD1PINE TRANSDERMAL...

R 0 C 3 0 6CAS,I)

UB/TIB Hannover

'

PharmaceuticalTechnology Conference

Oxford • U.K.March 19th-21st 1996

CHRIST CHURCH COLLEGE ANDTHE TOWN HALL, OXFORD, UK

VOLUME 2Wednesday, March 20th, 1996

PharmaceuticalTechnology

CONFEHENtCE;

Oxford U.K.

WEDNESDAY March 20th

PLENARY LECTURE: Main Hall

8.30-9.00 PRESENT AND FUTURE TRENDS INPHARMACEUTICAL PACKAGINGDixie A. Dean, Consultant, U.K.

9.30 - 9.50 QQEEsE

RESEARCH PAPERS:

CONTROLLED DRUG DELIVERYMain Hall

9.50-10.20 PENETRATION OF LIPID MONOLAYERS BY A 14STEROIDAL DRUGR. Parmar, D.Q.M. Craig, K.M.G. Taylor & M.Thomas, School of Pharmacy, London Universityand Glaxo Wellcome Inhalations, U.K.

10.20-10.50 SLOW RELEASE OF TRYPANOCIDAL DRUGS 18FROM BIODEGRADABLE POLYESTERSY. Lemmouchi, E. Schacht, P. Kageruka, R. DeDeken & S. Geerts, University of Gent and Instituteof Tropical Medicine, Antwerp, Belgium.

10.50 -11.20 SUSTAINED RELEASE OF INJECTABLE ZINC • 30RECOMBINANT HIRUDIN CO-PRECIPITATES:DEVELOPMENT AND VALIDATION OFRELEASE MODELU. Gietz, T. Arvinte & H.P. Merkle, Swiss FederalInstitute of Technology Zurich and Ciba-Geigy,Switzerland.

UB/TIB Hannover113 797 648

89

InternationalAdvisory Board

F. CariiTrieste, Italy.

O.I. CorriganDublin, Ireland.

J. CucalaBarcelona, Spain.

M.A. DonsmarkCopenhagen, Denmark.

J.L FordLiverpool, United Kingdom.

M.J. GrovesChicago, USA.

A.M. Cuyot-HermannLille, France.

T.M. (onesLondon, United Kingdom.

K.A. KhanNottingham, United Kingdom.

|.W. McCinltyAustin, USA.

|. RakBratislava, Slovak Republic.

H. RupprechtRegensburg, Germany.

A. StammStrasbourg, France.

Conference Co-ordinator

M.H. RubinsteinLiverpool, United Kingdom.

Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2E|,United Kingdom

Telephone:National 0151 737 1993,International +44 151 737 1993

Fax:National 0151 737 1070,International +44 151 737 1070


arid 21 s t |

C0iNFEMENCE

Oxford U.K.

11.20-11.50 IN VITRO RELEASE CHARACTERISTICS OFCHLORPHENIRAMINE MALEATE FROMINDIVIDUAL SUSTAINED RELEASE BEADS: ANINVESTIGATION INTO THE FACTORSRESPONSIBLE FOR THE OBSERVEDVARIABILITYJ.A. Cowan, A. Griffin, M.A. Hayward & T.J.Grattan, Smith Kline Beecham ConsumerHealthcare and South Bank University, U.K.

TRANSDERMAL DRUG DELIVERYMAIN HALL

11.50-12.20 DEVELOPMENT AND IN VITRO EVALUATIONOF NIMOD1PINE TRANSDERMALFORMULATIONS USING FACTORIAL DESIGNS.A. Giannakou, P.P. Dallas, D.M. Rekkas & N.H.Choulis, University of Athens, Greece.

12.20-12.50 DERMAL ENHANCEMENT USING NOVELAZONE ANALOGS AND HYDROCORTISONE ASMODEL DRUG IN HAIRLESS MOUSE SKINB.B. Michniak, MR. Player, D.A. Godwin & J.W.Sowell, University of South Carolina, U.S.A.

12.50 -14.00 LUNCH: Tudor Hall, Christchurch

40

10.00-12.5014.00-17.00

14.00-16.30

16.30-17.00

TABLE-TOP EXHIBITION: AssemblyRoom, Old Library & Panel Room

POSTER-SESSION: Assembly Room,Old Library & Panel Room

TRANSDERMAL DRUG DELIVERYMain Hall

IN VIVO QUALIFICATION OF THE ADHESIVEPROPERTIES FOR SOME PRESSURESENSITIVE ADHESIVESD.F. McCafferty & R.K. Malcolm, The Queen'sUniversity of Belfast, U.K.

51

62

74


F. CarliTrieste, Italy.


). CucalaBarcelona, Spain.


|.L. FordLiverpool, United Kingdom.


A.M. Guyot-HermannLille, France.

T.M. tonesLondon, United Kingdom.


J.W. McGinityAustin, USA.

|. RakBratislava, Slovak Republic.



Conference Co-ordinotor


Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2E),United Kingdom




March 19th, 20th and 21st Oxford 1996CONFERENCE

Oxford U.K.

17.00-17.30

17.30 -18.00

18.00-19.00

19.00

20.00

ASSESSMENT OF DAILY OESTRADIOL 77DELIVERY FROM DRUG IN ADHESIVETRANSDERMAL SYSTEMSA.W. Jenkins, G. Hewson & p. Gibson, EthicalPharmaceuticals Ltd., U.K.

THE USE OF MODULATED DIFFERENTIAL 83SCANNING CALORIMETRY IN THE STUDY OFHUMAN STRATUM CORNEUMN.J. Coleman, D.Q.M. Craig & A. Williams, Schoolof Pharmacy, London University, U.K.

PLENARY LECTURE:Main Hall

MEASURING THE MIX - ASSESSINGTHE CONSISTENCY OF WETGRANULATION USING MIXER-TORQUERHEOMETRYRay C. Rowe, Zeneca Pharmaceuticals,U.K.

CAPSUGEL RECEPTIONMcKenna & Ante-Room, ChristchurchCollege

CONFERENCE GALA EVENINGTudor Hall, Christchurch College


F. Carl)Trieste, Italy.




|.L. FordLiverpool, United Kingdom.

M.|. GrovesChicago, USA.


T.M. JonesLondon, United Kingdom.


J.W. McGinltyAustin, USA.

J. RakBratislava, Slovak Republic.




MM. RubinsteinLiverpool, United Kingdom.

Conference Address:

24 Menlove Gardens North,Liverpool L18 2E|,United Kingdom




Oxford 1996CONFERENCE

Oxford U.K.

WEDNESDAY MARCH 20th

RESEARCH PAPERS:

CAPSULES: Court Room

9.50-10.20 THERMAL ANALYSIS OF SELECTED 88NSAIDS/POLOXAMER SOUD DISPERSIONFORMULATIONS, WITH RESPECT TO LIQUIDFILLING INTO HARD GELATIN CAPSULESA. Utting, G. Rowley, N. Kassem & J. Lough,University of Sunderiand and Lilly Research CentreLtd., U.K.

10.20 -10.50 THE EFFECT OF MECHANICAL MIXING ON GEL 102RHEOLOGY FOR LIQUID-FILL HARD GELATINCAPSULE FORMULATIONSM.J.H. Ellison, G. Rowley, P A Walters & A.J.Coupe, University of Sunderiand and Pfizer CentralResearch, U.K.

GRANULATIONCourt Room

10.50 -11.20 A NEW APPROACH TO SCALE-UP OF A HIGH- 111SHEAR GRANULATION PROCESS USED IN THEMANUFACTURE OF METOPROLOL TARTRATETABLET FORMULATIONSG.Singh Rekhi, R. Caricofe, D.M. Parikh & L.Augsburger, University of Maryland, U.S.A.

11.20-11.50 THE INFLUENCE OF PLASTICI2ERS ON THE 125MORPHOLOGY AND MECHANICALPROPERTIES OF SPHERONISED GRANULESC. Wang, N.H. Shah, G. Zhang, M.H. Infeld, A.W.Malick & J.W. McGinity, University of Texas atAustin, Hoffmann-La Roche Inc. and HallmarkPharmaceuticals, U.S.A.




j . CucalaBarcelona, Spain.


J.L. FordLiverpool, United Kingdom.











Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2E|,United Kingdom




March 19th, 20th and 21 st Oxford 1 996CONFERENCE'

Oxford U.K.

FORMULATIONCourt Room

11.50-12.20 INFLUENCE OF EXOGENOUS FACTORS ON 127THE FORMULATION OF DRUG FORMS WITHPOTENTIAL LOCAL ANAESTHETICSZ. Vitkova, K. Gardavska, J. Cizmarik & J. Rak,Comenius University, Bratislava, Slovak Republic.

DISINTEGRATIONCourt Room

12.20 -12-50 BONDING AND DISINTEGRATION PROPERTIES 139OF LACTOSE AND MICROCRYSTALLINECELLULOSEF. Ferrari, M. Bertoni, M.C. Bonferoni, S. Rossi, C.Caramella & C. Nystrom, University of Pavia, Italyand Uppsala University, Sweden.

12.50 -14.00 LUNChL Tudor Hall, Christchurch

10.00-12.5014.00 -16.30

14.00 -17.00

17.00-17.30

TABLE-TOP EXHIBITION: AssemblyRoom, Old Library & Panel Room

POSTER-SESSION: Assembly Room,Old Library & Panel Room

EXCIPIENTSCourt Room

STUDY OF DIFFERENT TRICALCIUMPHOSPHATES' FROM DIFFERENT SOURCESP. Conflant, C. Barthelemy, A-M. Guyot-Hermann &J-C. Guyot, Universite of Lille II and University ofScience of Lille Flandres-Artois, France

148









T.M. |onesLondon, United Kingdom.


|.W. McGinityAustin, USA.






Conference Address:

24 Menlove Gardens North,Liverpool L18 2E|,United Kingdom





Oxford U.K.

17.30-18.00

18.00-19.00

19.00

20.00

THE EFFECTS OF MOISTURE CONTENT ANDPARTICLE SIZE ON THE FUNCTIONALPROPERTIES OF MICROCRYSTALLINECELLULOSE FOR USE IN DIRECTCOMPRESSIONM. Celik, B.E. Sherwood, R.C. Moreton, J.D. Cobb,D.J. Schaibie & J.A. Zeleznik, Rutgers University,Piscataway and Mendell Co., U.S.A.

PLENARY LECTURE:Main Hall

MEASURING THE MIX - ASSESSINGTHE CONSISTENCY OF WETGRANULATION USING MIXER-TORQUERHEOMETRYRay C. Rowe, Zeneca Pharmaceuticals,U.K.

CAPSUGEL RECEPTION:Me Kenna & Ante-Room, ChristchurchCollege

CONFERENCE GALA EVENING:Tudor Hall, Christchurch College

161InternationalAdvisory Board



). CucalaBarcelona, Spain.

MA. DonsmarkCopenhagen, Denmark.










Conference Co-ordinotor


Conference Address:

24 Menlove Gardens North,Liverpool L18 2E),United Kingdom




March 19th, 20th and 21 s\[ Oxford 1996CONFERENCE

Oxford U.K.

WEDNESDAY MARCH 20th

ON DISPLAY 14.00 - 1630Assembly Room, Old Ubrary &

Panel Room

EMULSIONS

31. DRUG DIFFUSION FROM MICROEMULSIONS 172E. Khalil, Jordan University, Jordan

32. OSMOTIC INDUCED PHASE INVERSION OF 177MULTIPLE W/0/W INTO A W/O EMULSION:TRANSFORMATION OF PHASE INVERTEDEMULSION INTO A W/0/W EMULSIONE. Fredro-Kumbaradzi, F. Popovska-Pavlovska, A.Simov & K. Goracinova, University 'St Cyril andMethodius', Skopje, Macedonia.

EXCIPIENTS

33. A COMPARATIVE EVALUATION OF THE 184PROPERTIES OF VARIOUS CELLULOSESK. lida, K. Aoki, K. Danjo, A. Otsuka & C.Y. Chen,Meijo University, Japan.

34. EVALUATION OF ERA-TAB AS A DIRECT 195COMPRESSION EXCIPIENTS-H. Hsu, T-R Tsai, W-H. Chuo & T-M. Cham,Kaohsiung Medical College, Republic of China.

DISINTEGRATION

35. EVALUATION OF FAST DISINTEGRANTS IN 210TABLETS CONTAINING A GAS EVOLVINGDISINTEGRANT: DISSOLUTION OFTERFENADINE TABLETSH. Ibrahim, E. Sallam, R. Abu Dahab, M. Shubair &E. Khalil, ACDIMA and APM, Jordan.







M.|. GrovesChicago, USA.










Conference Address:

24 Menlove Gardens North,Liverpool L18 2EJ,United Kingdom




March; 19th, 20th and 21 st Oxford 1 996CONFERENCE

Oxford U.K.

GRANULATION

36. RELATIONSHIP BETWEEN THE PHYSICAL 225PROPERTIES OF GRANULES AND TABLETSMADE FROM CRUDE DRUG POWDERS ANDTHE PHYSICAL PROPERTIES OF THE BINDERSOLUTIONK. Konishi, H. Sunada, Y. Yonezawa, K. Danjo & H.Yamaguchi, Meijo University, Japan

37. PREPARATION OF CARBOPOL GRANULES BY 240FLUID BED GRANULATION: IMPROVEMENT OFCOMPRESSION ABILITY INDICESD.C. Ferreira, E. Vilar, A.P. Rocha, P. Costa & J.M.Sousa Lobo, University of Porto and LaboratoriesBial, Portugal.

38. THE INFLUENCE OF PROCESS VARIABLES ON 247PELLETIZATION IN A SMALL SCALE HIGHSHEAR MIXERL. Maggi, R. Bettini, P.L. Catellani, G. Massimo, P.Santi & P. Colombo, University of Parma, Italy.

EXPERIMENTAL DESIGN

39. PARTIAL LEAST SQUARES ANALYSIS IN THE 259PREDICTION OF CONTACT ANGLES FORPHARMACEUTICAL MATERIALSE.Suihko, A. Poso, J. Gynther & P. Paronen,University of Kuopio, Finland.

MANUFACTURING

40. APPLICATION OF MANUFACTURING 265EXECUTION SYSTEMS IN PHARMACEUTICALPRODUCTIONM.Meyer, Consilium, U.K.

41. ORBITAL WELDING FOR HYGIENIC 278PHARMACEUTICAL AND BIOTECHNOLOGYAPPLICATIONSB.K. Henon, Arc Machines Inc, U.S.A.

















Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2EJ,United Kingdom




March 1 9th, 20th and 21st Oxford 1 996CONFERENCE

Oxford U.K.

TRANSDERMAL DRUG DELIVERY

42. IN VITRO EVALUATION OF A SERIES OF AMINO 296ACID ANALOGS AS DERMAL PENETRATIONENHANCERS IN HAIRLESS MOUSE SKINT.K. Fincher, S.D. Yoo, M.R. Player, J.W. Sowed Sr& B.B. Michniak, University of South Carolina,U.S.A.

43. ENHANCEMENT OF PERCUTANEOUS 303ABSORPTION OF A LORAZEPAMTRANSDERMAL THERAPEUTIC SYSTEM, BYAZONEP. Costa, D.C. Ferreira, R. Morgado & J.M. SousaLobo, University of Porto, Portugal.

44. OPTIMISATION OF TRANSDERMAL RELEASE 314OF N.S-A.I.D.'SS. Braha, I. Popovici, M. Dumitrache, M., Pavelescu& E. Braha, University of Medicine and Pharmacy'Gr. T. Popa', Rumania.

VAUDATION

45. THE ROLE OF THE INSTRUMENT 327MANUFACTURER IN THE QUALIFICATION OF ASPECTROMETER BASED SYSTEMJ.P. Hammond, ATI Unicam, U.K.

MEDICAL DEVICES

46. INFLUENCE OF BIOMATERIAL SURFACE 330CHARACTERISTICS ON ENCRUSTATION OFURETERAL STENTSM.M. Tunney, P.F. Keane & S.P. Gorman, TheQueen's University of Belfast and Belfast CityHospital, U.K.

47. ASSESSMENT OF THE MECHANICAL 333PROPERTIES OF POLYURETHANE URETERALSTENTSM.C. Bonner, M. Akay, D.S. Jones, P.F. Keane &S.P. Gorman, Belfast City Hospital, Queen'sUniversity of Belfast and University of Ulster, U.K.



O.I. CorrlganDublin, Ireland.



JX. FordLiverpool, United Kingdom.











Conference Address:

24 Meniove Gardens North,Liverpool L18 2E),United Kingdom




/vtarch 19th, 20th and 21st Oxford 1996CONFERENCE

Oxford U.K.

48.

49.

MIXING

POWDER MIXING: COMPARATIVE STUDY OFPILOT SCALE AND SEMI-INDUSTRIALBLENDERSJ.M. Sousa Lobo, A.P. Rocha & R. Morgado,University of Porto and Laboratories Bial, Portugal.

TABLETS 0.4mg:THE KEY TO

BLENDTABLET

336

343

345

348

FOLIC ACIDVALIDATIONUNIFORMITYC. Haughey, D. O'Callaghan & P.D. Moir, ClonmelHealthcare Ltd., Ireland

MICROBIOLOGY

50. INFLUENCE OF SALIVA IN MICROBIALADHERENCE TO ENDOTRACHEAL TUBESD.S. Jones, J.G. McGovem, A.D. Woolfson & S.P.Gorman, The Queen's University of Belfast, U.K.

51. MODIFICATIONS OF THE SURFACE CHARGEOF CANDIDA ALBICANS DO NOT DIRECTLYACCOUNT FOR THE ANTI-ADHERENCEPROPERTIES OF THE NON-ANTIBIOTIC,ANTIMICROBIAL AGENT CETYLPYRIDINIUMCHLORIDED.S. Jones, L.J. Schep & M.G. Shepherd, TheQueen's University of Belfast, U.K. and Universityof Otago, New Zealand

MODELLING

52. PARAMETER ESTIMATIONS IN MODELS FOR 351ENZYMATICALLY ACTIVE MEMBRANESG. Dimitriu, University of Medicine and Pharmacy'Gr. T. Popa', Rumania.

OCULAR DELIVERY

53. OCULAR BIOAVAILABILITY OF TIMOLOL 360FORMULATED IN AN IN SITU GELLINGCARRAGEENAN VEHICLEG. Chastaing, J. Grove, A. Rozier & B. Plazonnet,Merck-Sharp & Dohme-Chibret Laboratories,France.















Conference Co-ordlnotor


Conference Address:






Oxford U.K.

PARENTERAL NUTRITION

54. IMPORTANCE OF THE CALIBRATION FOR A 362PARENTERAL NUTRITION POCKETVOLUMETRIC FILLING PUMPC. Brilloit Petit, E. Brudieu, F. Le Gorrec, C. Villier,F. Chauvelot, P. Trouiller & J. Calop, CentreHospitalier Universitaire, Grenoble, France

POLYMORPHISM

55. THE EFFECT OF PHARMACEUTICAL 363ADDITIVES ON THE PHYSICOCHEMICALPROPERTIES OF ETHINYLOESTRADIOLE. Sallam, N. Salman, T. Arafat & R. Zaru, ArabManufacturing Company, A.P.I.C.O., JordanUniversity and University for Women, Jordan.

56. HABIT MODIFICATIONS OF PARACETAMOL 365CRYSTALS AND THEIR TABLETINGCHARACTERISTICSH.A. Garekani, J.L. Ford, M.H. Rubinstein & A.R.Rajabi-Siahboomi, Liverpool John MooresUniversity, U.K.

57.

58.

59.

CRYSTALLINE FORMS OF ELGODIPINE 389HYDROCHLORIDE - A NEW CALCIUMANTAGONISTJ. Cucala, X. Alberich & J. Mestre, Prodesfarma,Spain.

POWDER CHARACTERISATION

INVESTIGATION INTO THE COMPLEXATION OFNON STEROIDAL ANTI-INFLAMMATORYDRUGS WITH CAFFEINEJ.J. Gerber, M.M. de Villiers & W. Liebenberg,Potchefstroom University for CHE, South Africa.

PARTICLE SIZE SEPERATION AND ANALYSISOF A COMMERCIAL MAGNESIUM STEARATEPOWDERD.G. Brown, D.Q.M. Craig, J.M. Newton & G.T.Simpkin, University of London and Rhone-Poulenc-Rorer, U.K.

403

412

















Conference Address:





March T9th,2Oth and 21st Oxford 1996CONFERENCE

Oxford U.K.

65.

66.

67.

68.

69.

BIOACTMTY

ACUTE TOXIC TEST OF SWEDISH BITTERS -MEDICINE FOR LONG UFE - USING ARTEMINASALINA (LEACH)N.I. Yao Fiagbe, University of Science &Technology, Kumasi, Nigeria.

TRANSEPITHELIAL TRANSPORT OF ABORONATED DI-PEPTIDE ACROSS A CELLMODEL: HCT-8J.G. Eley, I.H. Hall, M.C. Miller III & A.L Elkins,Universities of Samford, Alabama and NorthCarolina at Chapel Hill, U.S.A.

BIOADHESION

TENSILEFILMS BY

MECHANICAL CHARACTERISATION OFBIOADHESIVE PERIODONTAL GELS USINGTEXTURE PROFILE ANALYSISD.S. Jones, A.D. Woolfson & J Djokic, The Queen'sUniversity of Belfast, U.K.

453

471

482DETERMINATION OF THEPROPERTIES OF BIOADHESIVEMEANS OF A TEXTURE ANALYSERA.D. Woolfson, D.F. McCafferty & C.R. McCallion,The Queen's University of Belfast, U.K.

AN INVESTIGATION INTO THE BIOADHESIVE 493NATURE OF MYVEROL18-99P.B. Geraghty, D. Attwood, J.H. Collett & Y.Dandiker, University of Manchester, U.K.

505

















Conference Address:

24 Menlove Gardens North,Liverpool LI 8 2EJ,United Kingdom



Pharmaceutica ' l - GBV11.50-12.20 DEVELOPMENT AND IN VITRO EVALUATION OF NIMOD1PINE TRANSDERMAL...

Documents

Transcript of Pharmaceutica ' l - GBV11.50-12.20 DEVELOPMENT AND IN VITRO EVALUATION OF NIMOD1PINE TRANSDERMAL...