pharm pack

8/18/2019 pharm pack

1/20

Generic Drug Name Trade name Disease / Condition

Isotretinoin Accutane Acne; Vitamin A derivative

ddI (Dideoxyinosine) ddI, Videx, etc. antiviral

Zidovudine (AZT) AZT, Retrovir antiviral

DNAase Dornase

Hydroxyurea Hydrea ic!le cell anemia

Imatinib "leevec #$% (c&ronic myelo'enous leu!emia)

Allourinol %ourin, etc.

!et"otrexate $T, Amet&oterin

Anti*iotics

#luoro$uinolones #iro anti*iotics

!etronida%ole +la'yl anti*iotic

Tetracycline Tetracyn anti*iotic

&i'amycin Riamin, etc anti*iotic, anti-T

teroids (////sone)

#ortone "lucocoticoid 0 a mineralocorticoid

#luticasone (a steroid) +lonase

rednisone (a steroid)

clear *ronc&ioles clo''ed 1it& viscous DNA(as in #ystic i*rosis)

In&i*its ant&ine oxidase; decreases lasma

uric acid levelsin&i*its DH+R en2yme; results in decreasedsynt&esis o nucleotides

Cortisone / Cortisol (steroid)

a steroid; used to treat ast&ma; #34D,*ronc&itis, aller'ic r&initis

3rasone,Delatasone

In&i*its &os&oliase A5; results in less4rosta'landins, %eu!otrienes


2/20


3/20

Cloidogrel 4lavix

itamin 0

1ar'arin #oumadin Vitamin 9 anta'onist

Hearin (2222arin) activates anti-t&rom*in

4ain 8 +ever 8 inlammation

Acetamino"en Tylenol

Iburo'en

Indomet"acin

Narcotic anal'esics

3ium (oioids)

Codeine!or"ine

Heroin

oeramide Imodium stays in "I tract; slo1s do1n eristalsis

Naloxone 3iod anta'onist

Re'ulate *lood 'lucose levels

Asirin (Acetylsalicylic acid) In&i*its #3-: and #3-5, lessrosta'landins made

Irreversi*le in&i*itor o AD4 recetors onlatelets

involved in activation (*y 'amma-car*oxylation) o *lood clottin' actors

In&i*its #3-: and #3-5, less

rosta'landins made; #N reerenceNAID; in&i*its #3, less rosta'landinsmade

NAID; in&i*its #3, less rosta'landinsmade

3iods rom oium lant (many al!aloids,mor&ine main in'redient)

1or!s via µ, δ, γ recetors (in&i*itory)1or!s via µ, δ, γ recetors (in&i*itory)

1or!s via µ, δ, γ recetors (in&i*itory)


4/20

Insulin

Glucagon

!et'ormin "luco&a'e Insulin sensiti2er; : tar'et is liver

3ul'onyl ureas Amaryl, etc. #lose 9< c&annels in *eta cells;Acarbose 4recose amylase in&i*itors in "I tract

$i'litol "lyset amylase in&i*itors in "I tract

Rosi'lita2one TZDs Insulin sensiti2er; mostly in adiose tissue

4io'lita2one TZDs Insulin sensiti2er; mostly in adiose tissue

"%4-: ("luca'on-li!e etide)

Decrease *lood liid levels

3tatins (2222statin) 7'. %ovastatin in&i*its c&olesterol synt&esis

4rlistat Alli, enical

#ibrates Tricor, etc activate liorotein liase

-%etimibe Zetia 4revents c&olesterol a*sortion in intestine

Niacin Niasan, etc In&i*its &ormone-sensitive l iase

#&olestiol #&olestid

#is" oil

Anti-oxidants 4revent oxidation o %D%

"I dru's

4mera%ole (2222ra%ole) 4rilosec

Cimetidine (2222tidine) Ta'amet H5 (Histamine tye 5) recetor *loc!ers

!isorostol #ytotec Acetylc&oline Increases "I motility and secretions

*inds a surace recetor, activates intrinsictyrosine !inase

activates 'luca'on recetors (" rotein-couled)

3ne o t&e Incretins t&at increases insulinrelease

*ind, s=uester and remove *ile acids viaeces

mec&anism not clear; lo1ers %D%, increasesHD%

44I; *inds irreversi*ly to roton um andinactivates it.

4"75 analo'; decrease acid secretion,

romote mucus secretion


5/20

Dicyclomine

Histamine

"astrin

omatostatin##9

4"75 (rosta'landin) In&i*its acid secretion *y arietal cells

Alco&ol Deresses #N

Disul'iram Anta*use In&i*its alde&yde de&ydeo'enase

3steoorosis

#alcium sulementation-strogen relacement sex &ormone

&aloxi'ene (3-&!)

Ibandronate (2222dronate)

Calcitonin

TH

Autonomic Nervous ystem

#&oliner'ic a'onist

#&oliner'ic a'onist

#&oliner'ic a'onist

ilocarine 4iloine $uscarinic a'onist

Nicotine

$uscarine a'onsit at muscarinic recetors

$uscarinic anta'onist; decreases acidsecretion

H5 recetor activation; increases acidsecretion

a'onist in *one, anta'onist 8 artial a'onistelse1&ere

is&os&onates, decrease osteoclastactivity

*et"anec"ol (#&oliner'ica'onist)

Carbac"ol (#&oliner'ica'onist)

!et"ac"oline (#&oliner'ica'onist)

a'onist at nicotinic recetors (*loc!er at &i'&conc)


6/20

-dro"onium 7nlon Acetylc&oline 7sterase in&i*itor

Neostigmine (2222stigmine) 4rosti'min Acetylc&oline 7sterase in&i*itor

yridostigmine (2222stigmine) $estinon Acetylc&oline 7sterase in&i*itor

"ysostigmine (2222stigmine) Antilirium Acetylc&oline 7sterase in&i*itor

Donee%il Aricet Acetylc&oline 7sterase in&i*itor (#N)

Rivasti'mine 7xelon Acetylc&oline 7sterase in&i*itor (#N)

Atroine Atroin $uscarinic *loc!er; enters #N at &i'& conc.

3coalamine Hyoscine $uscarinic *loc!er; also readily enters #NIratroium ////troium $uscarinic *loc!er (reers lun's)

Glycoyrrolate Ro*inul $uscarinic *loc!er

ralidoxime (A!) 4rotoam Antidote to insecticide (nerve 'as) oisonin'

4rgano"os"ates Nerve 'ases

3arin Nerve 'as

-c"ot"io"ate 4&os&oline

3uccinylc"oline Anectine Deolari2in' N$> *loc!er

Curare ///#?R/// Non Deolari2in' N$> *loc!ers

Gallamine +laxedil Non Deolari2in' N$> *loc!ers

*otulinum toxin otox

Dantrolene Dantrium in&i*it release o calcium rom sarcolasm

Irreversi*le in&i*itor o acetylc&olinein&i*itors



#leaves NA4-5@ rotein re=uired ordoc!in' o acetylc&oline-containin' vesicles;revents acetylc&oline release


7/20


8/20

4indolol 4artial a'onist

Ace*utolol 4artial a'onist

abetalol Trandate al&a : *loc!er and *eta *loc!er

Carvedilol #ore' al&a : *loc!er and *eta *loc!er

Albuterol (2222terol) Ventolin

almeterol erevent

$etaroterenol

Ter*utaline ret&ine

&itodrine Butoar

T"eo"ylline

#romolyn odium Nasalcrom

Tyramine 7exor

-"edrine 7&edrine

Am"etamine Adderall

!et"yl"enidate Ritalin

C4!T in"ibitor

!A4 in"ibitor

*eta 5 a'onist; increases cA$4; relaxessmoot& muscle





in&i*its cA$4 4D7 in lun's; lo1 t&eraeuticindex

ta*ili2es mast cell mem*rane; In&i*itsde'ranulation

recursor to noreine&rine; ric& in 1ines

and c&eese; t&ese oods are contraindicatedin atients on $A3 in&i*itors

7ntacaone(#omtan)

COMT is the enzyme that inactivatescatecholamines

ele'iline(Derenyl)

$A3 is an en2yme t&at inactivatescatec&olamines


9/20

Cocaine dru' o a*use

Tricyclic anti5deressants Deranil, 7lavil

33&Is 4ro2ac, Zolot, etc.Dia%eam (2222%eam) Valium en2os increase #l- current

+lunitra2eam en2os; increase #l- current

idocaine (2222caine) loc!s Na< c&annels; no nerve transmission

Histamine %ocal vasodilator

Di"en"ydramine enadryl H: (&istamine-:) *loc!er

Cimetidine (2222tidine) Ta'amet H5 (&istamine-5) *loc!er

Adenosine Adenocard %ocal vasodilator; s&ort &al-lie o seconds

-ndot"elin 4raxilene

osentan Tracleer 7ndot&elin anta'onist

Ni'ediine (2222diine) 4rocardia

eraamil

Diltia2em #a5< c&annel *loc!er; Vasculature #ardiac

Hydrala%ine Aresoline Arterial vasodilator; oen 9< c&annels

!inoxidil Ro'ain, Re'aine Arterial vasodilator; oen 9< c&annels

in&i*its reuta!e o doamine, serotonin, andN7

Imiramine, amitrytaline; in&i*its reuta&eo N7 and serotonin

+luoxetine (4ro2ac), ertraline (Zolot), etc.

&ave adrener'ic side eects

Ro&ynol, Rooies,etc.

4etide &ormone; syner'istic 1it& RAAat&1ay

*loc!s #a5< c&annels; Vasculature CC

#ardiac#a5< c&annel *loc!er; cardiac CCVasculature


10/20

Digitalis7 Digoxin Di'an inotroe; treatment or &eart ailure

!ilrinone (2222none) 4rimacor cA$4 4D7 in&i*itor; &eart 8 vasculature

3ildena'il (2222a'il) Via'ra c"$4 4D7@ in&i*itor

Renal

Aldosterone Rea*sor*s Na


11/20

!ec"anism

de'rades viscous DNA and &els clear lun's

in&i*its usion !inase resent only in cancer cells

4r&ylactic treatment or c&ronic 'out

anti-mitotic a'ent; anti-cancer a'ent

in&i*it *acterial DNA 'yrase 8 tooisomerase

treat acterial and arasitic inections

In&i*its *acterial rotein synt&esis

Natural &ormone made *y adrenal cortex

Anti-inlammatory dru'

Anti-inlammatory dru'

Alters 'ene exression; causes *irt& deects; youn'emales &ave to *e on *irt&control ills *eore Accutane is rescri*ed

in&i*its DNA synt&esis *y reverse transcritase;

c&ain terminator in&i*its DNA synt&esis *y reverse transcritase;c&ain terminator

#ytotoxic dru'; results in increased exression oetal &emo'lo*in

In&i*its *acterial RNA olymerase; also in&i*its

&uman mitoc&ondrial RNA olymerase


12/20

In&i*it &eler T cell activation via calcineurin

In&i*it &eler T cell activation via calcineurin

Treat $acrocytic or me'alo*lastic anemia

4romotes R# ormation; 'ro1t& actor or R#s

"H 1or!s via somatomendins (made *y liver)

Increases *ot& serum #a5< and &os&ate levels

In&i*it &eler T cell activation *y in&i*itin' rotein

synt&esis (via mT3R at&1ay)

Iron, or&yrin and 'lo*in are re=uired orassem*lin' &emo'lo*in

treat $acrocytic or me'alo*lastic anemia; treatin'neuroat&y due to :5 deiciency

&un'er si'nal; romotes 'luconeo'enesis; antidoteto treat overdose o *eta *loc!ers

"ro1t& actor, ana*olic, romotes transort onutrients ('lucose, amino acids, 9


13/20

anti-coa'ulant; tar'et latelets

anti-coa'ulant; ta!es days *eore ully eective

anti-coa'ulant; &as to *e in6ected; 1or!s raidly

ain reliever, reduce ever

ain reliever, reduce ever and anti-inlammatory

ain reliever, reduce ever and anti-inlammatory

narcotic ain reliever narcotic ain reliever

narcotic, addictive and dru' o a*use

common anti-diarr&eal dru'

treat oioid overdoase

rolonds *leedin' time; also used to treat ever, ainand inlammation

deiciency leads to rolon'ed *leedin' time; ina*ilityto clot *lood


14/20

anta'onistic to 'luca'on; lo1ers *lood 'lucose levels

Treat tye 5 dia*etes

oral &yo'lycemic; more insulin releasedTreat tye 5 dia*etes



decreases lasma liid levels

treat &yerliidemias

treat &yerliidemias

treat &yerliidemias

treat &yerliidemias

Decrease acid secretion

Decrease acid secretion

treat adverse eects o NAIDs

anta'onistic to insulin; increases *lood 'lucoselevels

cometitively in&i*its !ey en2yme H$"-#oAreductase


15/20


16/20

treat $yast&enia 'ravis

treat $yast&enia 'ravis

also enters #N; treat overdose o atroine

Al2&eimerEs disease

Al2&eimerEs disease

treat or'ano&os&ate oisonin'

Transdermal atc& 8 revent motion sic!ness

Recovers acetylc&oline esterase activity i 'iven early

used as insecticides, 1arare

used as insecticides, 1arare

used to treat 'laucoma

Treat mali'nant &yert&ermia

&ort &al lie o minutes; used to test or myast&enia'ravis (Tensilon test)

mostly cosmetic use; aroved or treatin' ocaldystonias


17/20

treat &yertension

treat &eoc&romocytoma

treat *eni'n rostate &yertro&y

emer'ency anti-&yertensive

c&oice anti-&yertensive durin' re'nancyerectile dysunction

neurotransmitter released *y adrenal medulla;emer'ency si'nal

neurotransmitter released *y symat&etic nerveterminals


18/20

Anti-&yertensive

Anti-&yertensive

treat ast&ma, #34D

treat ast&ma, #34D

treat ast&ma, #34D

treat ast&ma, #34D

treat remature uterine contractions

ronc&odilator

ro&ylactic treatment or ast&ma

increase catec&olamines

increase catec&olamines li!e doamine; treatmentr 4ar!insonEs


19/20

addictive and &as many ot&er #N eects

anti-anxiety dru's

*anned in ?A; date rae dru'

%ocal anest&etic

treat aller'ies

reduce acid secretion

constricts *lood vessels

treat ulmonary &yertension

anti-&yertensive

Toical or &air 'ro1t&

anti-deressants; selective serotonin reuta!e

in&i*itors


20/20

Treat erectile dysunction

timulates ums in 4rincial cells

diuretic; 9< sarin'

anti-&yertensive

Raises 4; used in some &osital settin's

Vasodilator; lo1ers 4

No clinical use

Treat ulmonary &yertension

Treat edema, #H+

Treat &yertension

Treat &yertensionTreat &yertension

in&i*its Na89 AT4ase um; increase cytosoliccalcium levels; increases ontractility and cardiacoutut

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