(Continuedfrom page 722)Polymer Materials. An Introduction for Technolo-

gists and Scientists. Christopher Hall. 2nd ed. Halsted(Wiley), New York, 1988. x, 243 pp., illus. $39.95.

Practical HPLC Method Development. Lloyd R.Snyder, Joseph L. Glajch, and Joseph J. Kirkland, Wiley-Interscience, New York, 1988. xviii, 260 pp., illus. $45.Preservation of Tubo-Ovarian Function in Gyne-

cologic Benign and Malignant Diseases. KihyoeIchinoe, Sheldon J. Segal, and Luigi Mastroianni, Eds..Raven, New York, 1989. xvi, 680 pp., illus. $98. SeronoSymposia Publications from Raven Press, vol. 48.

Principles and Applications of Photochemistry.Richard P. Wayne. Oxford University Press, New York,1988. xiv, 268 pp., illus. $55; paper, $24.95. OxfordScience Editions. Revision of Photochemistry.

Principles of Feedback Control. George Biernson.Wiley-Interscience, New York, 1988. 2 vols. Vol. 1,Feedback System Design. xxx, 497 pp., illus. $59.95.Vol. 2, Advanced Control Topics, xxx, 637 pp., illus.$69.95.Prospects in Systematics. D. L. Hawksworth, Ed.

Published for the Systematics Association by Clarendon(Oxford University Press), New York, 1988. xx, 457 pp.,illus. $92. The Systematics Association Special Volumeno. 36. From a symposium, London, U.K., July 1987.Proton Passae Across Cell Membranes. Gregory

Bock and Joan Marsh, Eds. Wiley-Interscience, NewYork, 1988. x, 268 pp., illus. $54.95. Ciba FoundationSymposium, vol. 139. From a symposium, London,U.K., Feb. 1988.

Psychoanalytic Process Research Strategies.Hartvig Dahl, Horst Kachele, and Helmut Thoma, Eds.Springer-Verlag, New York, 1988. xx, 334 pp., illus.$25. Based on a workshop, Hamburg, F.R.G., July1985.Psychological Testing. Principles, Applications,

and Issues. Robert M. Kaplan and Dennis P. Saccuzzo.2nd ed. Brooks/Cole, Pacific Grove, CA, 1988. xxii, 618pp., illus. $40.50.

Self-Directed Behavior. Self-Modification for Per-sonal Adjustment. David L. Watson and Roland G.Tharp. 5th ed. Brooks/Cole, Pacific Grove, CA, 1988.xvi, 334 pp., illus. $25.75.

Siliceous Deposits of the Tethys and PacificRegions. James R. Hein and Jelena Obradovic, Eds.Springer-Verlag, New York, 1989. x, 244 pp., illus. $69.Based on a conference, Yugoslavia, Sept. 1986.Social Behaviour in Fluctuating Populations. An-

drew Cockburn. Croom Helm (Routledge Chapman andHail), New York, 1988. xii, 249 pp., illus. $69.50.Studies in Behavioural Adaptation.

Soil Physics. T. J. Marshall and J. W. Holmes. 2nded. Cambridge University Press, New York, 1988. xii,374 pp., illus. $89.50; paper, $29.95.

Spiral Grain and wave Phenomena in WoodFormation. John Maddern Harris. Springer-Verlag,New York, 1989. xii, 214 pp., illus. $99. Springer Seriesin Wood Science.

State Variable Methods in Automatic Control.Katsuhisa Furuta and Akira Sano with Derek Atherton.Wiley, New York, 1988. viii, 212 pp., illus. $39.95.Surveys of Some Recent Resuit in Operator

Theory. Vol. 2. John B. Conway and Bernard B. Morrell,Eds. Longman Scientific, Harlow, U.K., and Wiley,New York, 1988. xiv, 266 pp. Paper, $59.95. PitmanResearch Notes in Mathematics, vol. 192. Based on alecture series, Bloomington, IN, 1985-86.Telephone Survey Methodology. Robert M.

Groves et al., Eds. Wiley, New York, 1988. xxii, 581 pp.$44.95. Wiley Series in Probability and MathematicalStatistics. From a conference, Charlotte, NC, Nov. 1987.

Theoretical and Computational Aspects of Simu-lated Annealing. P. J. M. van Laarhoven. Centrumvoor Wiskunde en Informatica, Amsterdam, 1988. viii,168 pp. Paper, Dfl. 25.30. CWI Tract 51.Theory of Discrete and Continuous Fourier Anal-

ysis. H. Joseph Weaver. Wiley-Interscience, New York,1989. xii, 307 pp., ilius. $39.95.A Theory of the Evolution of Development. Wal-

lace Arthur. Wiley-Interscience, New York, 1988. x, 94pp., illus. $34.95.

Turtles and Tortoises of the World. David Alder-ton. Facts on File, New York, 1989. 191 pp., illus.$22.95.The Undeclared Bomb. Leonard S. Spector. Bal-

linger (Harper and Row), Carnbridge, MA, 1988. xx,499 pp. $34.95; paper, $12.95. The Spread of NuclearWeapons.

Volcanic Hazards. Assessment and Monitoring.John H. Latter, Ed. Springer-Veriag, New York, 1989.xiv, 625 pp., illus. $98. Proceedings in Volcanology, vol.1. From a congress, New Zealand, Feb. 1986.

PersonnelPlacement

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POSITIONS WANTED

Chemist, Biochemist, Physiological Sciences, Ph.D.,M.D., Extensive teaching: clinicaland analytic biochem-istry, cancer, instrumentation; visible, UV, infrared,TLC, GC, electrophoresis, fluorometry; governmcnt,academic/hospital. Box 354, Rochelle Park, NJ 07662.

Clinical Chemist Ph.DIComputer Science A.D. IBM-PC-DOS, Advanced Basic, Cobol, RPG, research inhealth care, QC, supervisory experience. Hard-working.Seeking a challenging position. Telephone: 804-523-1284 evenings.

Flow Cytometry Operator. Experienced in operatingand managing a flow cytometry facility involved in celcycle and immunofluorescence analysis and sorting. Willrelocate. 2 Clifton Road, Clifton, NY 14431.

POSITIONS WANTED

Immunobiology Research Team; M.D. and Ph.D.'s;experienced in field of antigenspecific and nonspecificregulatory mechanisms in no immune and autoim-mune responses, hybridoma technology, cell cloning,immunoassays, protein purification, and some experiencein molecular biology; good funding and publicationrecord; experienced in grant application preparation,teaching and administration, seeing positions in acade-mia or industry. Box 67, SCIENCE.

Immunologist. Ph.D. Highly skilled scientist with expe-rience in cellular immunity in cancer and infectiousdiseases, hybridoma and monoclonal technology, and cellculture. Creative problem solver with excellent manage-ment and communication skills. Seeking position inacademic medicine or biotechnology R&D. Box 57,SCIENCE.

Immunologist, Ph.D. 1975. Mature scientist seeksacademia/research institute position in immunotherapyof leukemia/lymphoma. Medical school background.Teaching skills. Peer-reviewed publications. Availableimmediately. Box 61, SCIENCE.

Reproductive/Developmental Biologist D.V.M.,Ph.D. Extensive research experience in sperm motionanalysis; early mammalian embryo development; repro-ductive toxicology and immunology. Seeks challengingacademic or industrial position. Box 72, SCIENCE.

Research Scientist, Ph.D. Looking for an interestingresearch project. Background in wound healing, plasmaproteins, and connective tissue. Box 70, SCIENCE.

Toxicologist, Ph.D., Board-certified with 10-plus yearsof industral experience seeks position in California:chemical, consumer product, pharmaceutical, and haz-ardous waste site experience. Box 71, SCIENCE.

POSITIONS OPEN

ANIMAL NUYTRIONIST position with primaryresponsibility for comprehensive applied research pro-gram in fish nutrition, diet formulation, feed technology,and feeding strategies. Require Ph.D. or M.S. withmnimmum of 4 years of experience. Desire strongbackground in general animal nutrition, comparativephysiology, biochemistry, and analytical instrumentationanalysis. Send letter of application with resume by26 May 1989. For fiuther information, contact: Dr.Robert A. Busch, Clear Springs Trout Company,P.O. Box 712, Buhl, ID 83316. Telephone: 208-543-8217 Fax: 208-543-5608.

ANIMAL PHYSIOLOGIST. Search reopened. As-sistant professor, tenure-track, beginning August 1989;teach two courses per semester with laboratories; animalphysiology, comparative vertebrate anatomy, humananatomy, another course for majors or non-majors;supervise undergraduate research; advise. Ph.D. re-quired. Seton Hill College is a Catholic liberal artscollege for women, 35 miles east ofPittsburgh. By 2 June1989, send three letters ofrecommendation, statement ofteaching and research goals, eguipment needs, curricu-lum vitae, and transcripts to: Sister Bernadettc Fondy,Ph.D., Department of Biology, Seton Hill College,Greensburg, PA 15601. An Equal Opportunity/Alfimwa-tive Action Institution.

The University of California, Davis, School of Medi-cine, is recruiting for a full-time faculty member to bejointly appointed, 50% in the Department of Pharmacol-ogy and 50% at the California Primate Research Center.Appointment will be at the ASSISTANT OR ASSO-CIATE PROFESSOR level commensurate with quali-fications and experience. Candidates must have a Ph.D.and experience in reproductive and developmental phar-macology/toxicology. Responsibilities will include teach-ing at the medical and graduate student level.A letter outlining research and teaching background

and identifying current research interests, along withcurriculum vitae and the names of three references, mustbe received by 1 August 1989.

Reply to: Larry G. Stark, Ph.D., Professor andChairman, Department of Pharmacology, School ofMedicine, University ofCaliforniia, Davis, CA 95616.

The University ofCalifomia is an Afirmative Action/EqualOpportunity Employer.

PERSONNEL PLACEMENT 725I2 MAY I989

POSITIONS OPEN

APPLIED SCIENTISTS sought, B.S., M.S., Ph.D.,for environmental permitting. Prefer training and/orexperience in southeastern United States. Expertisesought in botany, wildlife, wetlands, CAD, GIS, waterquality, statistics. Send resume to: Personnel Depart-ment, Breedlove, Dennis and Associates, Inc., 2412Forsyth Road, Orlando, FL 32807. An Equal Opportu-.nity Employer.

ASSISTANT PLANT PATHOLOGISTAT

WSU-PROSSER (IAREC)Position is available 1 October 1989, or as soon as a

qualified candidate is selected. This is a tenure-track,100% research appointment, to conduct research onhop, grapevine, and other selected crops. Candidate willassume leadership in planning and implementing re-search programs, plant pathology, and cropping systemsmanagement. Strong background in virus and fingaldiseases is desired. Position located at Washington StateUniversity's Irrigated Agriculture Research and Exten-sion Center (WSU-IAREC), Prosser, Washington,where over 35 scientists work with 35 to 40 crops. Ph.D.is required; a degree or training in plant pathology ispreferred. Salary is commensurate with training andexperience. Send resume, copies of publications, tran-scripts, and at least three letters of reference, by 1 August1989, to: Dr. G. S. Santo, Search Committee Chair-man, POB 30, WSU-IAREC, Prosser, WA 99350.Telephone: 509-786-2226. WSU is an Equal Opportuni-ty/Affirmative Action Educator and Employer. Members ofethnic minorities, women, Vietnam-era or disabled veterans,persons with disability, and/or persons between the ages of40 to70 are encouraged to apply.

ASSISTANT PROFESSORAPPLIED MATHEMATICS

Assistant professor level of applied mathematics. Thisis a tenure-track position. A person is sought with anactive research program in the application of mathemat-ics and/or statistics to toxicology and occupational medi-cine. Candidates are sought w-ho have an interest in themathematical modeling of biological events. Currentresearch programs involve modeling carcinogen bio-chemistry, neurotoxicity of chemicals, pharmacokineticsof xenobiotic chemicals, deposition of chemicals in therespiratory tract and cancer surveillance. Active collabo-ration in one or more of these areas is available. Teachingresponsibility for basic statistics and decision theory tomedical and graduate students. Excellent computationalfacilities, including supercomputing, available.Send curriculum vitae and names offive references to:

Dr. D. B. Menzel, Professor and Chairman, Depart-ment of Community and Environmcntal Medicinc,University of California, Irvine, CA 92717.

The University ofCalifomia is an Afirmative Action/EqualOpportunity Employer.

ASSISTANT RESEARCH SCIENTIST FLOWCYTOMETRY: New York University (NYU) MedicalCenter is seeking an individual to operate and manage aflow cytometry facility. The facility has an Ortho OHdual laser sorter and a FAC scan analyzer. It is a corelaboratory and serves the needs of a diverse group ofscientists engaged in basic research in immunology,hematology, molecular biology, and cell biology. Re-sponsibilities include operation, troubleshooting andmaintenance of the sorters, data analysis, collaborativeexperimental design, and training/teaching of users. Can-didate must have 2 years of experience with a master's orbachelor's degree in science plus equivalent experience.Excellent salary and benefits package. Send curriculumvitae to: Joan Harmon, Personnel Department, NYUMedical Center, 550 First Avenue, New York, NY10016. Equal Opportunity Employer M/F.

ASSISTANT RESEARCH SCIENTIST IN EN-DOCRINOLOGY with experience in measurement ofsteroid receptors and studies on the mechanism of hor-mone action in the Department of Physiology andEndocrinology. Ph.D. in endocrinology with 4 years ofrelevant experience required. Salary: $25,000 per an-num. Qualified applicants apply with resume to: Geor-gia Departanent of Labor, 601 Greene Street, Augus-ta, GA 30913, or to the nearest Georgia Job ServiceCenter. Control #GA 5349466.

POSITIONS OPEN

ASSISTANT PROFESSORTenure-track assistant professor position for individual

with research interests in nutrition and internationalhealth or nutrition and immunology/infectious diseases.We are looking for a highly motivated individual withwell-developed ideas for pursuing his or her own inde-pendent research program. The Division of InternationalHealth and Public Health Nutrition has opportunitiesfor field research in Latin America and the Caribbean.Individuals with strong laboratory backgrounds and aninterest in international work are also encouraged toapply. The successful applicant will have a Ph.D. or M.D.degree with postdoctoral research experience and goodpotential for supporting his or her research via extramu-ral grant support. Send curriculum vitae and three lettersof reference to: Dr. Jose 0. Alvarez, Search Commit-tee, 303 Tidweli Hall, School of Public Health,University ofAlabama at Birmi , Birmingham,AL 35294. Telephone: 205-934-1732.UAB is an Equal Opportunity/Affimaive Acion Employer.

ASSISTANT PROFESSORCOLUMBIA UNIVERSITY COLLEGE OF

PHYSICIANS AND SURGEONSTenure-track position with a joint appointment in

the Departments of Ophthalmology and Biochemistryand Molecular Biophysics is available for an individualinterested in conducting independent research in themolecular biology ofthe visual system. We are particular-ly interested in control of gene expression and develop-ment, gene-related disease processes, and DNA repairand mutation. Applicants should have strong postdoctor-al experience in some aspect of molecular biology and agood publication record. Columbia University takes Affirm-ative Action to ensure Equal Opportunity. Send curriculumvitae and names and addresses of three references to:

Dr. Abraham SpectorCollege of Physicians and Surgeons

Columbia University630 West 168th StrectNew York, NY 10032

ASSISTANT PROFESSORCARDIOVASCULAR/BIOCHEMICAL

PHARMACOLOGYApplications are invited for a tenure-track assistant pro-

fessor position in the Department of Pharmacology andDivision of Cardiovascular Disease at the University ofAlabama at Birmingham. Applicants should have a Ph.D.in relevant area with two or more years of postdoctoraltraining. Interest and expertise in endothelial cell biologyand function in vivo and in vitro, EDRFs and EDCFs,signal transduction and second messengers studies isdesired. The successful candidate will be expected todevelop an independent research program with outsidefunding. ComPetitive salary and reasonable start-upfunds are available. Send curriculum vitae and threeletters of reference to: Dr. David D. Ku, Search Com-mittee Chairman, Department of Pharmacology,UAB Station, Box 402, Birmingham, AL 35294.UAB is an Equal Opportunity/Afirmative Action Employer.

ASSISTANT ORASSOCIATE PROFESSOR

PHYSIOLOGY AND BIOPHYSICSThree tenure-leading faculty positions are available at the

assistant or associate professor levels. Candidates shouldbe trained in either microcirculatory control, neuralcontrol of the circulation or cellular or molecular cardio-vascular physiology. A doctoral degree plus 2 years ofpostdoctoral experience is required. Faculty are expectedto develop active independent research programs and toparticipate in the teaching programs of the department.Salary, benefits, and set-up funds are attractively compet-itive. Applicants should submit curriculum vitae, a letterof research goals, and the names and addresses of threereferences by 30 June 1989 to:

Irving H. Zucker, Ph.D.Chaiman

Department of Physiology and BiophysicsUniversity of Nebraska College of Medicinc

42nd and DeweyOmaha, NE 68105

The University ofNebraska is an Equal Opportunity/Afirmative Action Employer.

POSITIONS OPEN

ASSISTANT PROFESSOR(RESEARCH SCHOLAR)FACULTY OF MEDICINE

DEPARTMENT OF PHYSIOLOGYUNIVERSITY OF ALBERTA

$32,564 to $46,700Applications are invited for the position of assistant pro-

fessor (research scholar) in the area of renal physiology.Qualifications indude a Ph.D. or M.D. degree and ademonstrated outstanding ability for independent re-search. The successful candidate will participate in thedepartment's teaching program (both graduate and un-dergraduate) and other academic activities. The positionwill depend upon funding through an extern agencysuch as The Alberta Hentage Foundation for MedicalResearch, and the effective date ofemployment is depen-dent upon the success of the application.

The University of Alberta is committed to the principle ofequity in employment.

Interested applicants should submit their curriculumvitae, an outline of proposed research, and the names ofthree referees by 30 June 1989 to:

Dr. Peter K. T. PangProfessor and ChairmanDepartment of Physiology

University of AlbertaEdmonton, Alberta

T6G 2H7

ASSOCIATE INVESTIGATOR Research in signaltransduction in human neutrophils and rat lung macro-phages. This is a hard money position to work withdigital image analysis and fluorescence spectroscopy onan NIH-funded project. Background in computers,UNIX, MS-DOS, signal analysis, biophysics and cellbiology desirable. Ph.D./M.S. or equivalent experience.Position can be structured for postdoctoral apphlcants aswell. Position available immediately. Reply and curricu-lum vitae to: Thomas D. Coates, M.D., Division ofHematology, Childrens Hospital of Los Angeles,4650 Sunset Boulevard, Los Angeles, CA 90027.Telephone: 213-669-2352.

ASSOCIATE RESEARCH SCIENTIST: Execu-tion of synthetic organic techniques involved in researchin chemistry of antifungal agents and separation sciencein an effort to realize new and novel chemical structures.Isolate and characterize new derivatives involving use ofhigh-pressure liquid chromotography equipment. Use ofvarious sophisticated spectroscopic instruments to ascer-tain structure and purity. Use of high field nuclearmagnetic spectrophotometers for obtaining structuralinformation. Analysis, evaluation and initia interpreta-tion of experimentation concerning synthetic organictechniques. M.S. in medicinal chemistry with concentra-tion in synthesis of nuclear anti-viral agents and anti-fungal agents. Coursework must include use of high-pressure liquid chromotography equipment and highfield nuclear magnetic resonance spectrophotometers.No experience necessary. Forty hours per week; $36,000per year. Send resume in duplicate to: J.O. # 3049023,Job Service Technical Unit, Connecticut Departmentof Labor, 200 Folly Brook Boulevard, Wethersfield,CT 06109.

RESEARCH ASSOCIATE BIOCHEMISTAND/OR JUNIOR FACULTY POSMIION

Multidisciplinary group interested in developing noveltherapeutic strategies for melanoma therapy based oncytotoxic melanin precursors, seeks a Ph.D. chemist/biochemist with experience reiated to melanin synthesis,intermediary metabolism, or anti-melanoma pharmaccu-tical development. Unique opportunity for creative sci-entists to work independently and in collaboration with ateam oforganc chemists, biochemists and cell biologistsin a well-funded laboratory with modern facilities forsynthetic, organic and radiosynthetic chemistry, analyti-cal biochemistry, tissue culture and in vivo ammal stud-ies. Competitive salary commensurate with educationand experience. The University of Pittsburgh is an EqualOpportunity/Affirmative Action Employer. Interested appli-cants should send curriculum vitae to:

William D. Bloomer, M.D.Professor and Chairman

Deparment of Radiation OncologyUniversity of Pittsburgh230 Lothrop Strect

Pittsburgh, PA 15213

SCIENCE,VOL. 244726

POSITIONS OPEN

BIOCHEMIST: Position open for biochemist. Pri-mary responsibilities: not more than 20% of time teach-ing medical biochemistry to medical students and at least80% of time for research. Please send curriculum vitaedetailing teaching experience, research interests, granttrack record and the names of three references to: Dr.Arnold L. Nagler, Associate Dean, Basic Sciences,.New York College of Osteopathic Medicine, OldWestbury, NY 11568. Afirmative Action/Equal Opportu-nity Employer.

BIOLOGICAL SCIENCE ADMINISTRATORBusiness manager of Biology Department, Texas A&MUniversity. Senior staff member, responsible for non-academic matters of40-faculty member department. TheDepartment conducts research and teaching in a range ofbiological topics with competitive research funding cx-ceeding $3 million annually. Individual will plan andsupervise fiscal management, $3.25-million departmentalbudget, and administrative activities; supervise supportstaff. Required: bachelor's degree in science, business orrelated field, 2 years of experience in higher educationadminitation. Preferred: Previous experience in re-search administration and acquisition of extramuralfunding, and a biological science background. Salary:commcnsurate with experience. Send curriculum vitaeand names of references by 15 June 1989 to: Dr. T. C.Hall, Hcad, Department of Bioloy, Texas A&M Uni-versity, College Station, TX 77843-3258. TAMU is anAfirmative Action/Equal Opportunity Employer.

BIOLOGY: Tenure-track position at the ASSIST-ANT PROFESSOR level. Starting date is 15 August1989. Emphasis will be vascular plant taxonomy. Ph.D.required by starting date. Successful applicant will partic-ipate in the undergraduate/graduate program in biologyand will develop a research program in plant taxonomy.Teaching responsibilities will include plant taxonomy,possibly mycology and economic botany. The selectedcandidate will also participate in our freshman biologycourse for nonmajors. Submit letters of application,curriculum vitae and the names, addresses, and telephonenumbers of three references to: Dr. George R. Hoff-man, Chair, Department of Biology, University ofSouth Dakota, Vermillion, SD 57069. Preference giv-en to applications received by 25 May 1989. EqualOpportunity/Afirmative Action Employer.

CELLULAR BIOLOGIST. The David M. ClarkCenter, Arkansas Children's Hospital invites applicationsfor a tenured-track assistant professorship beginning fall1989. Applicants should have a Ph.D. and 2 years ofpostdoctoral training. The appointee will join investiga-tors focusing on pediatric cardiac and lung disease. Theindividual would establish independent research andparticipate in collaborative projects involving pulmonaryvascular or myocardial cells. Prior experience with thesetissues is desirable but not a requirement. Opportunitiesfor teaching and joint appointments exist with the basicscience divisions of the University ofArkansas for Medi-cal Sciences. Send curriculum vitae, statement ofresearchinterest, and names of three references to: A. FrancineTryka, M.D., The David M. Clark CardiovascularCenter, 800 Marshall, Little Rock, AR 72202.

CELLULAR IMMUNOLOGIST. Full-time re-search position available with immunology/molecularbiology group studying human autoimmune diseases.Ph.D. and extensive experience with B cell cloning, and Bcell studies required. Expertise with cell sorting usingCoulter Epic C desirable. An Equal Opportunity Employer.Send resume to: Dr. Vincent Agnello, ENRM Veter-ans Hospital (151), 200 Springs Road, Bedford, MA01730.

CHAIRMANDEPARTMENT OF MEDICINE

Four hundred thirty-five-bed acute-care communityteaching hospital seeking Chairman, Department ofMedicine. Responsible for Internal Medicine ResidencyProgram and Transitional Year Residency Program.Serves as Administrative Physician in Department ofMedicine. Apply by submitting curriculum vitae to:Richard D. Herman, M.D., Chairperson, SearchCommittee for Chairman, Department of Medicine,St. Luke's Hospital, 801 Ostrum Street, Bethlehem,PA 18015. An Equal Opportunity Employer.

12 MAY I989

Continued expansion at Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, has created the following openings in our Reproductive ToxicologySection-

Senior ScientistThe duties of this position will be to study the deleterious effects of new drugs on thereproductive processes. The successful candidate will assist in the design, executionand analysis of studies which focus on the mother, embryo/fetus, newborn and wean-ing. The position will also involve supervisory responsibilities and drug discovery teamparticipation.Requirements for this position include a Ph.D. in Reproduction Biology or closely alliedfield, 1-3 years' post-doc experience in reproductive toxicology, knowledge of GLPs;experience in embryo culture techniques is necessary.

Assistant ScientistsThe duties of these positions will be to conduct reproductive and developmental toxi-cology studies and will include neuropharmacological/behavioral testing.Requirements for these positions include a BS degree in biological sciences and 1-5years' experience in these areas: animal handling, safety evaluation studies, neuro-pharmacological/behavioral testing and offspring evaluation techniques.Qualified candidates should send resume, salary requirements and reference list (in-dicating position desired) in confidence to: Ms. S. Hultquist, PARKE-DAVIS, 2800Plymouth Road, Ann Arbor, Michigan 48105.

PARKE-DAVISDIVISION OF WARNER-LAMBERT COMPANY

"Equal Opportunity in Action"

Research Scientist!Pharmacokinetics

Triton Biosciences Inc., a subsidiary of Shell Oil Company located inthe San Francisco Bay Area, is a fully integrated pharmaceutical anddiagnostics company focused on product development opportunitiesin the areas of cancer, AIDS and other serious diseases. We currentlyhave an opening for a Pharmacokinetics Research Scientist.

Your duties will entail design of pre-clinical and clinical pharmacokineticstudies for pharmaceutical compounds, selecting contract laboratoriesto perform these studies, analyzing pharmacokinetic data and writingreports and summaries for regulatory submission. Experience withpharmacokinetics computer programs, particularly NONLIN, is highlydesirable. You should have a PhD in Pharmaceutics or PharmaceuticalChemistry with a research emphasis in pharmacokinetics and 0-2years of relevant experience. Some travel is required.Triton offers competitive salaries and benefits, including relocationassistance. For consideration, send your resume with cover letterhighlighting your qualifications and including the names of threereferences to Triton Biosciences Inc., Employment-Dept. JJB, 1501Harbor Bay Parkway, Alameda, CA 94501. EEO/AA employer.

* Triton Biosciences Inc.

11111fli a

ro HAI 11 WI II I

POSITIONS OPEN

CLINICAL LABORATORYHEMATOLOGIST

The University of Washington School of Medicine,Department of Laboratory Medicine, is recruiting ajunior faculty assistant director ofthe Clinical Hematolo-gy Laboratories at the University Hospital. Candidatesshould be Board-certified in clinical pathology and have"demonstrated competence in the diagnosis of lympho-mas, leukemias, and immunodeficiency diseases withexpertise in flow cytometry, immunocytochemistry, andmolecular biology. Please sumbit curriculum vitae by 1June 1989 to: J. C. Detter, M.D., Department ofLaboratory Medicine, University ofWashington, SB-10, Seattle, WA 98195. The University of Washington isan Equal Opportunity/Affirmative Action Employer.

DIRECTORCLINICAL RESEARCH CENTERMEDICAL RESEARCH INSTITUTE

OF DELAWARE (MRID)The Medical Research Institute of Delaware seeks a

clinical research scientist/administrator for an excitingcareer opportunity involving the development and direc-tion of its Clinical Research Center (CRC). Contributingmembers to the Institute include the Du Pont Company,ICI Americas Inc., the Jefferson Medical College, theMedical Center of Delaware, and the University ofDelaware. The CRC will focus initially on clinical phar-macology studies in normal human volunteers and willbe involved with studies with the faculty of the contrib-uting institutions. The Director must have ability inresearch and administration and will interact with themedical, education, and health care communities, indud-ing state and national agencies. Candidates should havean M.D. degree, Board certification with eligibility formedical licensure in Delaware, and credentials warrant-ing a faculty appointrnent at the Jefferson Medical Col-lege and the University of Delaware. Send letters ofapplication, curriculum vitae, and three letters of refer-ence to: Pcter Chodoff, M.D., M.P.H., ChristianaHospital, P.O. Box 6001, Newark, DE 19718. MRIDis an Equal Opportunity Employer.

DIRECTOROREGON INSTITUTE OF

MARINE BIOLOGYThe University of Oregon is seeking a resident Direc-

tor for the newly rebuilt Oregon Institute of MarineBiology (OIMB) in Charleston, Oregon (starting date,September 1990). Applicants with an internationallyrecognized basic research program, evidence of adninis-trative skills, and demonstrated commnitment to excel-lence in undergraduate and graduate education shouldsend a letter of interest, resume and recent publications,and have letters sent from three referees to: Chair,OIMB Search Committee, Department of Biolog,vUniversity of Orcgon, Eugene, OR 97403. Tece.phonc: 503-6864526. Deadline for applications: 30June 1989. Target decision date, September 1989 orearlier.The Director's position will be tenurable in the De-

partment of Biology at the associate or full professorlevel; salary is negotiable. We especially scek a marineecologist as director who will complement our presentdepartmental strengths in population ecology and physi-ology. The Institute operates year-round with residentfaculty, staff, and students. It has immediate access toestuarine salt marshes and mud flats, diverse rockyintertidal habitats, high energy beaches, and open ocean.

The University ofOregon is an Equal Opportunity/Afirma-tive Acion Institution.

The Division of Endocrinology/Metabolism/ClinicalNutrition, Department of Medicine, at Oregon HealthScienccs University, has a position available for a DIVI-SION HEAD. Must have a proven record of accom-plishment in clinical medicine, teaching, research andadministrative activities at the associate professor/profes-sor level. The Division has six full-time faculty positionswith interests in lipid and calcium metabolism, diabetes,and hyperthalamic pituitary disorders. Interested candi-dates should send curriculum vitae along with the namesand addresscs of three references to: Dr. William M.Bennett, Professor and Head, Division of Nephrolo-gy L-463, Oregon Health Sciences University, 3181S.W. Sam Jackson Park Road, Portland, OR 97201.OHSU is an Affirmative Action/Equal OpportunityEmployer.

POSITIONS OPEN

THE UNIVERSITY OF TEXASAT DALLAS

DIRECTOR OF THE INSTITUTEFOR ENVIRONMENTAL SCIENCES

The University ofTexas at Dallas seeks annlications fora non-faculty research scientist position as Eirector ofthenewly established Institute for Environmental Sciences(IES). Through the use of simulation modeling, includ-ing analysis of model reliability, IES will address signifi-cant environmental issues by conducting multidis-ciplinary research that integrates scientific, social, andeconomic concepts. Aggressive leadership will be re-quired to launch the institute and to persuade specialistsfrom diverse backgrounds to participate in IES research.The successful applicant will be an established scientistwith competence in computer-based modeling, the abili-ty to secure external funding, and experience administer-ing multidisciplinary teams. Preferred areas of specializa-tion include: systems ecology or surface or groundwaterhydrology. Salary will be commensurate with experienceand qualifications. Applications must be received by 15June 1989 (indication of sex and ethnicity is requestedfor statistical purposes but is not required) and mustcontain a resume and a list of references who can becontacted. Applications should be sent to:

Search # 290The University of Texas at Dallas

P.O. Box 830688Richardson, TX 75083-0688

The University of Texas at Dallas is an Affirmative Action!Equal Opportunity Employer.

DIRECTOR, OFFICE OFBIOLOGICAL PRODUCT REVIEW

$68,700 to $76,400In addition, physicians may be eligible for a retention

bonus of up to $20,000 per annum.Incumbent directs 90 professional and support staff in

the evaluation and regulation of biological productspresented for investigational use or for market release.Applicants should have an M.D. degree from an ap-proved medical school or a doctorate in a related biologi-cal or physical science; experience at the executive level inplanning, directing and evaluating broad scientific re-search or regulatory programs and activities which dem-onstrate the ability to effectively coordinate and produc-tively integrate the multidisciplinary efforts ofa scientific,profissional and technological workforce; administrativeor managerial experience at the executive level whichdemonstrates strong leadership abilities in a scientificenvironment; and experience which indicates the abilityto implement Equal Employment Opportunity Pro-grams.

Application for Federal Employment, SF-171, is re-quired and must be received by 12 June 1989.For additional information contact: Mr. John Ander-

son, Division of Human Resources Management,Food and Drug Administrtion, Room 4B-09, HFA-408, Parklawn Buildi, 5600 Fishers Lane, Rockvile, MD 20857. Telephone: 301-443-1755.

An Equal Opportunity Employer.

Geo-Centers, Inc., a rapidly growing professional serv-ices research and development firm, specializing in chem-ical materials, biological and optical sciences, has animmediate opening for an ELECTRON MICROSCO-PYTECHNICIAN. This position involves the prepara-tion of samples for microscopic analysis, assist with themaintenance of SEM and TEM systems, obtain anddevelop micrographs and video recordings of samples,and perform freeze fracture preparations. The successfulapplicant should have demonstrated practical experiencein the operation and maintenance of SEM,TEM facili-ties, and possess a B.S. degree in chemistry, physics, orbiochemistry. Geo-Centers, Inc., offers competitive sala-ries, relocation assistance, and an outstanding benefitspackage. U.S. citizenship required. Qualified candidates areurged to send their resume, along with salary require-ments and history to: Geo-Centers, Inc., 10903 IndianHead Highway, Ft. Washington, MD 20744. Atten-tion: Deborah Hall-Groene/Code 2128. Geo-Centers,Inc., is an Equal Opportunity/Afirmative Acion Employer(Principals Only).

POSITIONS OPEN

DIRECTOR CLINICAL RESEARCH CENTER

Northwestern University seeks a Director for its Clini-cal Research Center (CRC). Candidates should hold anM.D. degree, be eligible for a senior faculty appointmentwith tenure and must have achieved national recognitionfor a biomedical research program. Candidates shouldhave previous experience as the Director or AssociateDirector of a CRC or comparable experience. The searchcommittee wishes to identify and interview qualified women orminority candidatesfor this position. Applications or nomina-tions, including curriculum vitae and a letter describingthe candidate's qualifications in detail, should be submit-ted to: Donald Nutter, M.D. Northwestern Universi-ty Medical School, Morton 4-656, 303 East ChicagoAvenue, Chicago, IL 60611-3008. Applications mustbe received by 1 August 1989. Northwestern University isan Equal Employment Opportunity/Affirmative Acion Em-ployer. Employment eligibility verification required upon hire.

FACULTY POSITIONMICROBIOLOGY AND IMMUNOLOGY

Applications for a tenure-track assistant professorshipare invited from candidates with a background in immu-nology utilizing molecular and/or cellular technologies.Candidates should have a Ph.D. or M.D. with provenability or high potential for an independent, funded,productive research program. Send curriculum vitae,bibliography, and statement of research and teachinginterests to:

John M. Lehman, Ph.D.Department of Microbiology/Immunology #A-68

Albany Medical College47 New Scotland Avenue

Albany, NY 12208The Albany Medical Center is an Equal Opportunity!

Afirmative Action Employer.UNIVERSITE DE MONTREAL

The Department of Pathology of the University ofMontreal Medical School invites applications for thefollowing FACULTY POSMIIONS:

(A) Associate or full professor M.D. and/or Ph.D.with experience in research in oncology and molecularbiology. The selected candidate will be expected to act asthe scientific coordinator of a developing group inoncogenetic research and to share teaching responsibil-ities, mostly at the graduate level. A good knowledge ofthe French language is preferable. Salary will be com-mensurate with academic level.

(B) Research professor M.D. and/or Ph.D. interestedin developing research in molecular genetic or molecularbiology. The candidate will integrate a research group inoncogenetics and will share responsibilities in teachingat all levels. The candidate's profile should allow compet-itiveness for the obtention of external research funds inthe 2 years following his or her arrival. A good knowl-edge of the French language is preferable.Send curriculum vitae and the names of three referees

by 15 June 1989 to: Dr. Jean Michaud, Chairman,Departmcnt of Pathology, Universite de Montral,P.O. Box 6128, Station "A," Montreal, Quebec, H3C3J7.

In accordance with Canadian immigration requirements, thisadvertisement is directed in priority to Canadian citizens andpermanent residents of Canada. The University ofMontreal isan Equal Opportunity Employer.

MICROBIOLOGY POSITION in 4-year liberalarts college, starting no later than February 1990. Excel-lence in college teaching emphasized. Must teach in thevarious areas of microbiology, immunology and cellbiology, or introductory biology. Credentials for asso-ciate or full professor appointment preferred. Letter,transcripts, and three letters of recommendation to: Dr.Edgar Webber, Chair, Microbiology Search Commit-tee, Natural Sciences, Keuka Colkge, Keuka Park, NY14478. Affirmative Action/Equal Opportunity Employer.

MOLECULAR BIOLOGY RESEARCH Ph.D.Oncology research position immediately available. Fo-

cus on c-able oncogene and growth factors. Salary$21,640 per year with benefits. Reply: Frank Andrews,M.D., Department of Medicine (111), VA MedicalCenter, 1660 South Columbian Way, Seattle, WA98108. Telephone: 206-764-2475 or 2878. U.S. citi-zenship, Equal Opportunity Employer, Hispanics, women, andminorities are encouraged to apply.

SCIENCE, VOL. 244728

POSITIONS OPEN

FARM ADVISOR-GROUNDWATER TOXI-COLOGY (Santa Clara, Alameda, Contra Costa andSan Matco Countics). Headquarters: Santa Clara Coun-ty. The University of California, Division ofAgricultureand Natural Resources, Cooperative Extension is seekinga career-track academic candidate to develop, conductand evaluate educational and research programs to ad-dress specific, identified problems within the subjectareas of groundwater toxicology, Froundwater ollutionand toxic materials for the residents of souem SanFrancisco Bay Area. Minimum Master's degree or equiv-alent combination of education and experience in a fieldrelated to groundwater toxicology, groundwater pollu-tion and/or toxic materials required. Doctorate levelcourse work or field experience preferred. Additionalcourse work or experience in an agricultural sciencepreferred. Knowledge of Cooperative Extension policiesand procedures desirable. Assure Affirmative Action in

development and delivery ofprograms. Beginning salary,Cooperative Extension Assistant Advisor rank, commen-surate with experience and professional qualifications.For complete description and application, contact: Uni-versity of California Division of Agricultare andNatural Resources Personnel, 6t Floor, 300 laeDrive, Oakland, CA 94612-3560. Teephone: 415-987-0088. Close 30 June 1989. Refer to #A-89-055.Afirmative Action/Equal Opportunity Employer M/F/H.

MARINE GENE PROBE IABORATORYDALHOUSIE UNIVERSITY

The Marine Gene Probe Laboratory (MGPL), recentlyestablished with funds from the Government of NovaScotia, will occupy a leading position in basic and appliedresearch in fish and shellfish genetics.MGPL is seeking to appoint:

RESEARCH ASSOCIATESPOSTDOCTORAL FELLOWS

SCIENTIFIC TECHNICAL STAFFGRADUATE STUDENTS

Experience of recombinant DNA and an interest in

fish/shellfish genetics is essential. These are term appoint-ment for 3 years, renewal contingent on funding. Sala-ries will be commensurate with experience and competi-tive internationally.The MGPL is located on Dalhousie University campus

in a dynamic Biology Deartment with strong links tothe Departments of Bioemistry and Oceanography,the Canadian Federal Government Laboratories of theDepartment of Fisheries and Oceans, and the BedfordInstitute of Oceanography. In accordance with Canadianimmigration requirements, this advertisement is direced to Cana-dian citizens and permanent residents of Canada. Other appli-cants will be considered ifno candidates meeting the above criteriaare availabk. Dalhousie University has a policy ofAfinnativeAction in hiring qualified women academic staff Applicationsincluding a fill curriculum vitae and three referencesshould be sent to: Dr. R. W. Doyle, Marinc GencProbe Laboratory, Department ofBiology, DalhousieUniversity, Halifix, Nova Scotia, Canada B3H 4J1before 15 June 1989.

CENTERS FOR DISEASE CONTROLCENTER FOR INFECTIOUS DISEASES

DIVISION OF HOST FACTORSMOLECULAR BIOLOGIST

A position is availabk to study molecular and cellularresponses ofhuman lymphoid cells involved in immuno-deficient, autoimmune, and/or infectious diseases. Thisposition is with Dr. Steven McDougal, Clinical Immu-nology Branch, Division of Host Factors. A M.D. orPh.D. is preferred with postdoctoral or appropriateresearch experience. Applicants should be capable ofcollaborative and independent investigations as evi-denced by publications. Salary range: $34,580 to$53,460, depending on experience. To apply, please sendcurnculum vitac and three names and add of refcr-ences by 1 August 1989, to:

Mr. William NelsonPersonnel Management Office, Room 1/1058

Centers for Disease Control1600 Clifton Road, NE

Atlanta, GA 30333CDC is an Equal Opportunity Employer and provides a

smoke-free work environment.

I2 MAY 1989

Researchsc tis

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pbharmaceutica/innovationlsisw/'ty/oubae in1mind,

cometoScberingflougb A'esearc/

We're a progressive $3-billion pharmaceuticalsleader recognized worldwide for our dedication todiscovery. We have the following rewarding researchopportunities:Scientist, Drug MetabolismRequires BS in Chemistry or Biology and 7 years'experience or an MS with 5 years' experience. Back-ground in H PLC, knowledge of drug metabolismand demonstrated strengths in modern analyticaltechniques essential.Associate Scientist, BiotechnologylBiochemistryRequires BS in Biochemistryand 4 years' experienceoran MS with 2 years' experience. Background withpurification and characterization of proteins isessential. Experience with techniques using columnchromatography, H PLC, gel electrophoresis, anduse of antibodies for detecting proteins preferred.Assistant ScientistWill support drug safety metabolism studies at ourLafayette, NJ Toxicology/Pathology lab. Requires BSin Biological or Animal Sciences and 2 years' experi-ence in both Histology and Necropsy techniques, oran MS degree.We provide competitive salaries and an excellentbenefits package. For prompt, confidential con-sideration, send resume to: Ms. P. Valendo,Schering-Plough Research, 60 Orange Street,Bloomfield, NJ 07003. We are an equal oppor-tunity employer.Watyou veimrmnd,Fwepuatfmactiom

1 Schering-Plough 1

-

SENIOR RESEARCH UNIVEK.ITYBIOCHEMISTTlGUELPH

The Merck Sharp and Dohme Research Laboratories is cur- DEPARTMENTS OF VETERINARYrently offering an excellent career opportunity for a MICROBIOLOGY AND IMMUNOLOGYBiochemist within the Antifungal Discovery Group in the AND

Department of Exploratory Microbiology and Genetics. Thegroup is responsible for the identification of targets forin- MOLECULAR BIOLOGY AND GENETICShibition of antifungal drugs, the development of screenswith which to select potential inhibitors, and confirmation Applications are invited for a tenure track position asof the mode of action of new inhibitors by development of assistant professor immunology. Responsibilities includeassays for specific inhibition. The successful candidate will research and teaching in the area of immunogeneticshave responsibility fprogratblisongded on the research particularly applications of molecular genetics to antibodygoals of the group. The incumbent will direct and perform design and production. The principal orientation is towards

basic and applied research on the biochemistry of fungal health maintenance in veterinary and human medicine. Theprocesses, particularly membrane-associated functions. A position will be central to a collaborative research programPh.D in Biochemistry or equivalent and significant postdoc- involving immunologists, geneticists and microbiologists.toral experience is desired. Relevant interest and experience Appointment will be made in the Department of Veterinaryin enzyme purification, assay development and biochemicalpathway dissection is preferred. Knowledge of fungal Microbiology and Immunology with a joint appointment in

physiology and/or genetics a plus. Ability and desire to work the Department of Molecular Biology and Genetics. Appli-as part of a team toward the development of antifungal cants should have a PhD in immunology with emphasis onantibiotics is essential. the molecular genetics of immunoglobulins and monoclonalMerck Sharp and Dohme Research Laboratories are located antibodies.in Rahway, New Jersey, approximately 25 miles from New In accordance with Canadian Immigration requirements,York City. Our salaries, benefits, and growth potential are . . . . .Canadian cexcellent. Interested candidates should submit their cur- prority will be given to Canadian citzens and permanentriculum vitae with the names of three references and salary residents of Canada. Subject to final budgetary approval.requirements to Ms. Dolores Barefield, Merck Sharp and Please address enquiries to Dr. Bruce Wilkie, Chairperson,Dohme Research Laboratories, P.O. Box 2000, WB 5362, Department of Veterinary Microbiology and Immunology,

Rahway,Now Jersey 07065.Ontario Veterinary College, University of Guelph, Guelph,Ontario, Canada, N1G 2W1. Applications will be accepteduntil June 30, 1989 or until the position is filled.

E K The University of Guelph is committed to EmploymentEquity.

iThe Sartorians say | BUILDING Anew labs need NEW LAB?perfect balance. LET THE SCIENCE FREE PRODUCT

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The Sartorians bring you perfect balance.In fact, from heavy-duty floor balances to SM L RT SALTE TTNultra-sensitive super micros, the Sartorians SIMPLY WRITE US A LETTER STATINGoffer the world's most technologically advanced THE SPECIFICS ABOUT YOUR PROPOSEDscientific balances.

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U.S. Department of Energy

POSTGRADUATERESEARCH PROGRAMSToxicologyFossil EnergyHazardous WastesEconomics/Energy Policy

ArtificialIntelligence

EngineeringPhysical SciencesEnvironmentalSciences

Life SciencesComputer SciencesRisk Analysis

* Research at national laboratories* Stipends $19-35,000 depending on

degree, program, research area* Recent graduate degree* U.S. citizens or PRAs eligible* Information

Postgraduate Research Programsf§ YD University Programs Division

IATJ Oak Ridge Associated Universities&IyJ-n P.O. Box 1 1 7

Oak Ridge, TN 37831-0117(615) 576-3190

ONE DISCOVERY

DESERVES ANOTHER

Boef* er Mwnnhem is a rpodfygmwro kaderin tefiadofMeicalRasew-ch end Biocheimk 7hs

kIads1mv has been attained through emphass on quaityend team effhft le to our growth, we ae currently

sekg quaIedWidAduds for the folgposiins atour Indieos hadqWter

APPLICATIONS SCIENTISTXi poston /sisesponsiLe fodevor ping new sboratoryoppications andprotocols for &xist* products, to act asa resource of technicdk7owkee for our nwketng and

tehnicservice deptments, to present technicalselnmVs to AW nd industial customers,end topaf?,apate in technicaltrainng for our field sales force.Minimum r nents indude lbbratory expenence in

Immunology, rfokcu/r Bil, or Protelf (emistry anda Ph. 1. i7aireated fhSdi Exceknt communicaion and

puuic Wp&* skA are requiiredr 7 position wilrequreapproximate* 10% trvl se respond to Dept.

RM

PROTEIN CHEMISTSTheae posbitu responblk for purificatn,

conju9ation and dwacta uaton ofimmunoregents fordijnos#c test develpment Minimum requirements

indude a BS Degree in Chemistry or &i denistly plus2 yeas post-graduate xpenience in proten chmistry.

Preference wvYbe given to oppkcants with a basickiowkd4e ofpreparative end enm ica

inmunodemnistry. Pease respond to Dept. G.F.S.

At Boehnnger Mennheim, we offer n exacitng anddiffing work environment as well as en excelentcompes aend beeft program. Ifyou meet the

above reqirements end wolddike tojin en orgntat ais a kader in its fide, we invite you to sedyour

resume with salwy history for confidentiacondaration.Pase desnate w/ich positn is of inteest. To inquire

about other qppotuAes notkW above, pklse caY our,vb Ahe at (317) 845-M himen Aesources, Boe er

A ,unham, P.G Box 501(1, 9115 HA'gue Road,InW4 I, IN 45 An Equal OppoftIIiry Enpyer

BOEHRINGERMANNHEIM

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NATIONAL INSTITUTE OF CHILD HEALTHAND HUMAN DEVELOPMENT

NATIONAL INSTITUTES OF HEALTH

POSTDOCTORAL FELLOWSHIPS IN HUMANAND PRIMATE DEVELOPMENT

The Laboratory of Comparative Ethology is seekingoutstanding candidates for several postdoctoralfellowships beginning October 1989, to study all aspectsof human and primate development, includingperceptual, cognitive, emotional, and social behaviorsfrom infancy to adulthood. Doctoral training inpsychology, biology, sociology, anthropology, or statisticsis required. Candidates must be U.S. citizens orpermanent residents. Salary range is from $24,000 -$27,000 depending on research experience. Relevantlaboratories are directed by Drs. Marc H. Bornstein,Michael E. Lamb, John Newman, Stephen J. Suomi,and David Symmes. A CV and three letters of referenceshould be sent to:

Fellowship CommitteeLaboratory of Comparative EthologyNICHD/NIH Kv

>9000 Rockville Pike -0Building 31, Room B2B15Bethesda, Maryland 20892 OHE>

NIH IS AN EQUAL OPPORTUNITY EMPLOYER

I

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m

POSITIONS OPEN

MOLECULAR CELL PHYSIOLOGISTSThe Department of Physiology and Biophysics of the

University of Texas Medical Branch at Galveston mvitesapplications for tenure-track positions at the assistant,associate, and full professor levels. Individuals with dem-onstrated competence in molecular approaches to cellphysiology are especially encouraged to apply. Candi-dates must have Ph.D. and/or M.D. degrees. Salaries andstart-up funds are highly competitive. The Departmnentoffers a stimulating scientific environment and is deeplycommitted to high-quality research and teaching. Sendcomplete curriculum vitae, including publications list,brief statement of future research plans, and names andaddresses of three references, to: Mrs. Ann Elbert,Department ofPhysiology and Biophysics, Universityof Texas Medical Branch, Galveston, TX 77550.UTMB is an Equal Opportunity/M/F/H/V Afirmative Ac-tion Employer. UTMB hires only individuals authorized towork in the United States.

MOLECULAR GENETICIST to conduct studieson the molecular mechanisms involved in neoplasticdevelopment. Must have at least 3 years of postdoctoralexperience in the identification and expression of mam-malian genes. Extensive experience with viral (includingretroviral) vectors in cell lines and transgenic mice thatexpress acive oncoproteins and other products in induc-ibfk and constitutive expres*ion systems is required.Extensive experience in the use of molecular diagnostictechniques such as the polymerase chain reaction toidentify genetic abnormality in cancer cells is required.Annual starting salary is $44,000. Submit curnculumvitae to: The Squibb Institute for Medical Research,Human Resources Department 100, P.O. Box 4000,Princeton, NJ 08543. An Equal Opportunity Employer.

NEUROSCIENTIST, RESEARCH ASSOCI-ATEINSTRUCTOR. Research position open imme-diately to study the electrophysio and anatomy ofbasal forebrain cholinergic neurons in mammals. Candi-dates should have a Ph.D. in an appropriate disciplineplus experience in immunohistochemistry and/or clectro-physiofogy of CNS neurons. $20,000 first year, 1 to 3years of support. Send curriculum vitae and name ofthree references to: Dr. Robert T. Matthews, Depart-ment of Medical Anatomy, Tcxas A&M University,College Station, TX 77843.

NEUROSCIENTISTS, CELL AND MOLECU-LAR BIOLOGISTS. Tenure-track faculty positionsopen in gross and microscopic anatomy. Research inter-ests in neurosciences, cell and molecuar biology. Rankand salary commensurate with experience. Rescarchstart-up funds available. Send curriculum vitae, statementof research interests, and the names and addresses ofthree references to: Dr. James C. Story, Chairman,Department of Anatomical Sciences, Meharry Medi-cal College, 1005 D. B. Todd Boulevard, Nashvill,TN 37208, by 17 July 1989. An Equal OpportunitylAfirmative Action Employer.

OB/GYN FACULTY POSMIION-POSTDOC-TORAL -The Department of Obstetrics and Gynecol-ogy, University of Oklahoma Health Sciences Ccnter inOklahoma City is seeking an individual with researchinterest in endometriosis. Training in immunology, bio-chemistry; Ph.D. required. Must be skillcd in studentand resident teaching, research design, and statisticalanalysis. Send curriculum vitae and bibliography: Rob-crt A. Wild, M.D., Associate Professor, Departmentof Obstetrics and Gynecology, University ofOlaho-ma College of Medicinc, P.O. Box 26901, 4SP720,Oklahoma City, OK 73190.

PHARMACOLOGIST: Faculty/research, assistantprofessor position for appropriate Ph.D. or Pharrn.D.Qualifications and cxperience must indude strong medi-cal school teaching skills and research accomplishmentsInterested qualified candidates are invited to send curric-ulum vitae including teaching experience, statement ofresearch interests, research background, prior and cur-rent funding, and the names of threc refcrences to:Robert E. Mancini, Ph.D., D. O., Associate Dean forAcademic and Research Affairs and Chairman, De-partment of Pharmacology/Toxicology and Experi-mental Therapeutcs, New York College of Osteo-pathic Medicine, Box 170, Old Westbury, NY 11568.

OREGON HEALTH SCIENCES UNIVERSITYCENTER FOR RESEARCH ON

OCCUPATIONAL ANDENVIRONMENTAL TOXICOLOGYNEUROTOXICOLOGICAL SCIENCES

Newly created, state-supported, multidisciplinaiy Centerin neuroscience-rich environment seeks potential or estab-lished independent SCIENTISTS primarily to conductbasic research on molcular and cellular mechanisms under-lying adverse actions of chemicals on the mammalianervous system. Specal intrst areas in xenobiotic-recep-tor-gene interactions, urbations of gaen-productexpression and their relationship to neurodegenerativediseases. Other areas indude behavioral toxicology; analyti-cal and synthetic chemisty; chronotoxicology; dcvelop-mental neurobiology and mutagenesis; geronto-neurotoxi-cology; immnunoneurotoxicology; neuroepidemiology;molecular neurophysiology; molacular toxicogenetics;neuroendocine and ncurosensory toxicology; toxicog-nosy; and tumorigenesis. Ten scientist and staff scientistpositions available (start-up 1989 to 1991) on term,tenure-track or tenure appointments equivalent to assistant,associate or full professor, dcpending on qualificatns,expenece and potentiaL Salares compeitive with othermajor universities, with 50%+ generated from fundedresearch. Submit fully developed application by 9 June1989 to: Dr. P. S. Spencer, Dirctor and Senior Scien-tst, Center for Research on and Environ-mental Toxicol , Oregon Heal S Universi,P.O. Box 8366, Pordand, OR 97207-8366. OregonHealth Sciences University is an Equal Opportunity AffirnativeAction Employer.

PHYSICAL OCEANOGRAPHER-CIRCULA-TION MODELER. The National Ocean Service has aGS-13 vacancy with duties that includc application ofcirculation models to estuaries, verification measure-ments, and information products. Experience in circula-tion modeling required. Quality raning factors include:extensive knowledge of physical oceanography and ad-vanced mathematics; knowledge of engineering relatedto oceanographic measurements and- data quantity;knowledge of automatic data processing. Submit SF171to arrive no later than 30 May 1989 to: NOAA/NCASCPersonnel Division, 11420 Rockville Pike, Rockville,MD 20852. For a copy ofVacancy Announcement NC/N-89-72NJH, call: 301-443-8105. Additional technicalinformation can be obtained from Dr. Hcnry R. Frcy at301-443-8510.

PHYSIOLOGY OF SPACEFLIGHTPhysiologist to manage NASA Space Shuttlc experi-

ments on cardiovascular, endocrine and rcnal rcsponsesto weightlessness in small and large primates. Ph.D.required with strong academic record of research andpublications in relevant field. Send resumn and threereferences to: Dr. Susanne Churchill, Associate Direc-tor, Institute for Circadian Physiology, 677 BcaconSteet, Boston, MA 02215; by 1 June 1989.

POSTDOCTORAL FELLOW: One position avail-able to participate in studies ofDNA repair in mammali-an cells. Will join research group utilizing enzymatic,mutational and molecular techniques to elucidate pro-cesses of DNA repair induced by x-rays and anticanceralkylating agents. Must have previous experience inbiochemistry and/or molecular biology. Starting salarydernds on experience. Send resume with names of two

erefcnces to: W. D. Henner, M.D., Ph.D., OregonHealth Sciences University, L586, 3181 S.W. SamJackson Park Road, Portland, OR 97201. EqualOpportunity Employer.

POSTDOCTORAL FELLOW: A postdoctoral po-sition is available in the Department of CardiothoracicSurgery of the New England Medical Center Hospitalsand Tufts University School of Medicine beginning 1July 1989 or earlier. Research will concentrate on therole of humoral mediators in solid organ preservation fortransplanation. Salary commnensurate with experience.Send curriculum vitae to: Raymond J. Connolly,PhD., Director of Surgical Research, Box 37, NcwEngland Medical Ccnter, 760 Washington Strcet,Boston, MA 02111. New England Medical Center is anEqual Opportunity Employer.

POLLUTION-CONTROL TECHNICIAN toconduct tests and field investigations to obtain data foruse by company engaged in sewer systems flow studiesand sewer systems flow measuring devices, using com-puterized instrumentation monitoring systems. Deter-mines sources and methods of controlling pollutants inwater and soil utilizing knowledge of engineering andphysics. Collects samples of gases from sewer systems toassist in evaluation of atmospheric pollutants. Collectswater samples from streams and lakes to assess pollutionproblem. Prepares samples to testing, records date, andprepares summaries and charts for review. Must haveB.S in hysics. Must be able to extensively travel to jobsites wnich may be located anywhere in the UnitedStates. Placing instruments in sewer systems by goingthrough a manhole is routine daily work. $27,000 peryear plus per diem and company van for travel. Resumeto: Mrs. Armstrong, Alabama Statc EmploymcntScrvice, P.O. Box 428, Huntsvillc, AL 35804. JobOrder No. AL0589248.

POSTDOCTORAL FELLOW: Two positions: (i)analysis of rat liver adhesion molecules (ii) characteriza-tion of hepatic or pancreatic stem cells. Competitivesalaries. Candidates with a Ph.D. or M.D., and experi-ence in molecular genetic, developmental, or immuno-logical methods should submit their curriculum vitae,reprints, and names of three references to: Dr. DouglasHixson, Medical Oncology, Rhode Island Hospital,593 Eddy Street, Providence, RI 02903. Equal Oppor-tunity/Affirmative Action Employer.

POSTDOCTORAL FELLOW IN INSECT BE-HAVIOR: A recent Ph.D. graduate in animal behavior,ecology, entomology or a related field is sought tocollaborate on studies of sexual selection and behavior infield crickets. Research includes field work and studies ina modern and well-equipped laboratory. Responsibilitiesinclude assisting in supervision of graduate and honorsresearch students and some undergraduate teaching. Theinitial appomtment is for 1 year and is renewable.Intended starting time is fall/winter, 1989. Send curricu-lum vitae including the names, addresses, and telephonenumbers of three referees by 15 July 1989 to: Dr.Wllliam H. Cade, Department of Biological Sciences,Brock University, St. Catharines, Ontario, CanadaL2S 3A1. In accordance with Canadian Immigration require-ments, this advertisement is directed to Canadian citizens andpermanent residents. Brock University is an Equal OpportunityEmployer.

POSTDOCTORAL POSMIION available June 1989or thereafter, for studies of bacterial chromosome struc-ture, involvement of DNA gyrase, and function ofprokaryotic repetitive sequences. This project will em-ploy biochemical, recombinant DNA, and modern mo-lecular biological techniques. Experience in nucleic acidbiochemistry and enzyme purification preferred. Elec-tron microscope expertise desirable. Send curriculumvitae and names/telephones of three references to: Dr. G.Ferro-LuTzzi Ames, Biochemistry Department, Uni-versity of California, Berkeley, CA 94720.

POSTDOCTORAL POSITION available immnedi-ately to study regeneration in the central and peripheralnervous system. Both in vivo and in vitro models will beused. Experience with animal models, cell biology, im-munochemistry and tissue culture desirable. Send curric-ulum vitae, names, addresses, and telephone numbers ofthree references, and a brief description of researchexperience to: R. Pitas, Gladstone Foundation Labo-ratorics for Cardiovascular Disease, University ofCalifornia, P.O. Box 40608, San Francisco, CA94140-0608.

POSTDOCTORAL POSITIONTUMOR VIROLOGY

NYU MEDICAL CENTERWe have recently discovered RNA covalently linked to

SV40 TAg and to the oncogene product p53. TheRNAs, the bonding and the possible significance tooncogenic transformation will be studied. Must be U.S.citizen or permanent resident. Send curriculum vitae andnames of three references to:

Dr. Robert CarrollD arment of Pathology

New York University Medical School550 First Avenue

New York, NY 10016

SCIENCE, VOL. 244732

POSITIONS OPEN POSITIONS OPEN

POSITIONS OPEN

POSTDOCTORAL OR RESEARCHPOSITION AVAILABLE INCELLULAR IMMUNOLOGY

FOR Ph.D. OR M.D.

Studies deal with immunopharmacologv of imrnmuno-suppressive agents including mechanisms of action at theccllular and molecular level, and use in tolerance induc-

*tion as part of a major program in transplantation.Salary is commensurate with experience and begins at

$24,000.Send curriculum vitae together with names of three

references to: Marvin R. Garovoy, M.D., Director,Immunogenetics and Transplantation Laboratory,University of California, 513 Parnassus Avenue,Health Sciences East, Room 520, San Francisco, CA94143.

Thte Uniiversity of California is atn Equal Opporttutnity!Affinnative Employer. Wometn atnd mnitnorities are encouraged toapply.

POSTDOCTORAL POSITION available for a sci-entist interested in the enzvmologv and molecular biolo-gv of peptide hormones including angiotensin, natrio-peptins and hvpothalmic peptides. Send resume andthree references to:

Professor I. B. WilsonDepartment of Chemistry

and BiochemistryUniversity of Colorado

Boulder, CO 80309-0215The University is atn Equial Opportutity Etnployer.

POSTDOCTORAL POSITIONIN HIV RESEARCH FORNUCLEIC ACID CHEMIST

A postdoctoral/research associate position is availableimmediatelv. We need a colleague to join in our effort toscale up swnthesis of antisense oligonucleotides and tojoin in collaborative studies on their chemotherapeuticeffect against HIV and other viral diseases. Both unmodi-fied and intemucleotide phosphate backbone modifiedanalogs of oligodeoxynucleotiles are under studv. [Proc.Natl. Acad. Sci. U.S.A. 85, 5507-5511 (1988); ibid., pp.7079-7083; ibid., pp. 7448-7451.] The candicateshould have a strong background in svnthetic nucleicacid chemistry. Salarv will depend on degree of experi-ence. Contact: Dr. Sudhir Agrawal (508-842-8921,extension 325) or Dr. Pau Zamecnik (508-842-8921, extension 331) or else send curriculum vitae andnames and telephone numbers of three references toeither of the above: c/o Personnel Office, WorcesterFoundation for Experimental Biology, 222 MapleAvenue, Shrewsbury, MA 01545.

At: Equal Opportunity/Affirtnative ActionEmployer M/F/H.

POSTDOCTORAL POSITIONMOLECULAR ENDOCRINOLOGY

Available summer 1989 to study glxcoprotein hor-mone gene expression using recombinant DNA and genetransfer procedures. Salary competitive. Send resume andthree references to: Dr. Margaret A. Shupnik, Box511, University of Virginia Health Sciences Center,Charlottesville, VA 22908. At: Equal Opportunity/Af-firnative Action E:nployer.

POSTDOCTORAL POSITIONSTwo postdoctoral positions are available in a multidis-

ciplinary program to study the molecular biologv of thelargest and most destructive group of viral plant patho-gens, the potvviruses. Laboratories in the Departmentsof Biochemistry, Agronomv and Plant Pathology at theUniversity of kentuckv are engaged in studies ofsXynthet-ic infectious RNA transcripts, transgenic plants carryingpotzviral genes, cistron mapping, polvprotein process-ing, function of viral proteins, and replication strategy ofpotyv^iruses. The salar, is $20,000 and positions areavailable immediatelv. Applicants should submit curricu-lum vitae and name of three references to either:

Robert E. Rhoads Arthur G. HuntDepartment of Biochemistry Department ofAgronomyMS 607 Medial Center or N212L AgriculturalUniversiy of Kentucky Sdences NorthLexington, KY 40536 Univesity of Kentucky

Lexngtoi, KY 40546The Utniversity of Kentucky is an Equial Opportunity/

Affirmative Action Employer.

12 MAY I989

GlaXo Inc. is not onl~ one of the Top 5 ethicalpharmaceuticalfirmns in Amlerica, uwe're also the fastestgrouwing research-oriented company in the countrY Aspart of our continuing grou'th, Glaxo is expanding itsresearch facilities in Research Trianigle Park, NorthCarolina to one million square feet, under the direction ofDr Pedro Cuatrecasas. This has created oppportunities for

POSTDOCTORALFELLOWSHIPSThe Departmnenits of Structuiral and Biophysical (hemnistryand LEnzymnology have positions for Post -DoctorclScientists. These positions are at,ailable for onte to threeYears to highly, quialified inditiidutals for research onl ati'ide rantige of topics cassociated u ith proteini - related druigtargets. O)pportui ities are at'ailable in the follou ing aCIeas.* Synthetic Peptide/Protein Chemistry andBiochemistry.

* Mass Spectrometry of Proteins and Glycoproteins.* X-ray Crystallography of Macromolecules.* NMR Studies of Macromolecular Systems includingProteins, Protein - drug and DNA - drug Interactions.

* Computational Chemistry and Knowledge-basedModelling.

* In vitro Enzymology.* Studies of Metabolic Control Pathways inCultured Cells.

Opportunlities exist Jor collaboratit e initeraoctionis iuith (auvide range of scientists at Glaxo and at the neighboringuinit ersities. Puiblicationi of research in leadinzg journlalsanid attendance at ntational scientific meetings andsyminposia are enicouiraged.Wie offer excellent compensation and beniefits, astiniuilatinig ui'ork eni ironmient thatfosters innoitatit 'eresearch and professional grourth. Candidates initerestedin these positions shouild send their curricilumisl v1itae,together uiith the nIamIes of three references, to:

Human Resources DepartmentJob #PF

Glaxo Inc.aXlP.O. Box 13398

Research Triangle Park, N.C. 27709

(No Phone Calls, Please)No Private Agency Referrals, Please

An Equal Opportunity Employer M/F/H/ V

Paving the way to a healthier world.

L

POSITIONS OPEN

POSTDOCTORAL POSITIONAvailable for research on mechanisms ofpathogenicity

of streptococci and Bacteroides. Work involves transposonmutagenesis, gene cloning, and chemical characterizationofvirulence factors. Requirements include a recent Ph.D.in microbiology or related field and experience in molec-ular biology, bacterial physiology, or biochemistry. Ap-pointment is for up to 3 years. Please send curriculumvitae and three letters of recommendation to: Dr. M. W.Stinson, Department of Microbiology, School ofMedicine and Biomedical Sciences, Statc Universityof New York, Buffalo, NY 14214. SUNY is an EqualOpportunity Employer.

POSTDOCTORAL POSITION available immedi-ately for a cell biologist to study endocytosis and theinteractions of pathogens with plants. The applcantshould have experience in biochemical, molecular, andultrastructural techniques. Prior work need not be withplants or in plant pathology. One-year appointment(renewable for two). Competitive salary. Send curricu-lum vitae, names of three references, and relevant publi-cations to: Dr. Lawrence R. Griffing, Department ofBiology, Texas A&M University, College Station, TX77843; telephone: 409-845-1625. TAMU is an EqualOpportunity/Affirnative Action Employer.

POSTDOCTORAL POSITIONPostdoctoral position available immediately in a multi-

disciplinary viral immunology research center to studythe immune responses to human cytomegalovirus. Expe-rience in molecular biology or immunology is required.Send curriculum vitae, research experience, and threeletters of recomrnendation to:

Ms. Marge MooreBiomedical Research InstituteChildren's Hospital of St. Paul

345 North Smith AvenueSt. Paul, MN 55102

POSTDOCTORAL POSITION available immedi-ately to particatete in research directed toward a molecu-lar understanding of cell differentiation and reproductionin the filamentous fungus Aspergillus nidulans. Classicaland molecular genetic approaches will be used to investi-gate the expression of essential genes and biochemicalfunctions of gene products. Experience in molecularbiology or genetics is desirable. Send resume and threeletters of reference to Dr. Bruce L. Miller, Departmentof Bacteriology and Biochemistry. University of Ida-ho, Moscow, ID 83843. Equal Opportunity/AfirmativeAction Employer.

POSTDOCTORAL POSITION-BOTANY-tostudy maternal and paternal effects on pollen tubegrowth, ovule fertilization, and embryo development.Skills in structural botany and interest in ecological/evolutionary questions required. Begins 1 September1989. Send curriculum vitae and three letters ofreferenceto: Dr. D. L. Marshall, Biology Department, Univer-sity ofNew Mexico, Albuquerque, NM 87131 by 10June 1989. UNM is an Equal Opportunity/AffirmativeAction Employer.

POSTDOCTORAL POSITION IN MOLECU-LAR NEUROBIOLOGY. IImmediate opening onNIH grants to study the neurotrophic effects of theinsulin-like growth factor gene family, nerve regenera-tion, synaptogenesis, or pathogenesis of diabetic neurop-athy. Location near scenic Rocky Mountains. Submitcurriculum vitae with names, and telephone numbers ofthree references to: Dr. Dougas Ishii, PhysiologyDepartmcnt, Colorado State University, Fort Collins,CO 80523. CSU is an Equal Opportunity/AfirmativeAction Employer.

POSTDOCTORAL POSITIONSSeveral postdoctoral positions are available immediate-

ly to work on channel protein-structure and function.Research experience in membrane biophysics, molecularbiology or protein engineering is required. Send resume,reprints, and two names of references to: Dr. MauricioMontal, University of California San Diego, La Jolla,CA 92093-0319. An Equal Opportunity/AffimativeAction Employer.

-a~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~734

APPLIED BIOSYSTEMS INC., the leading international manufacturer of instrument/reagent sys-tems for biotechnology research, is seeking accomplished professionals to be located at ourfacilities in the San Francisco Bay Area.

SCIENTISTS AND ASSOCIATE SCIENTISTSPositions are currently available for protein chemists, molecular biologists, organic and analyticalchemists with strong backgrounds in structural chemistry and separation sciences.

CHROMATOGRAPHIY-conduct research in promising areas for micromolecular separa-tions. Expertise in instrumentation dealing with HPLC and its use in protein or DNA isolation/characterization needed.

ELECTROPHORESIS-explore and develop novel directions in the separation of biomacro-molecules and their constituents. Analytical capillary electrophoresis and micropreparative isola-tions by HPEC are areas of current interest.

SEQUENCING-investigate/develop new chemical methodologies for the analysis of proteins.Experience in sample preparation, protocol development and methods troubleshooting required.A BS, MS or PhD in Biochemistry, Analytical or Organic Chemistry, or an equivalent combinationis required. Practical laboratory experience from 1-5 years and indepth understanding of instru-mentation essential. (Ref. #SC1891W)Qualified candidates may send their resume, (INDICATING THE REFERENCE CODE), to AppliedBiosystems, Inc., H.R. Dept., 850 Lincoln Centre Drive, Foster City, CA 94404. We are an equalopportunity employer.

_AppWd

Regulatory Toxicologists(Senior and Postdoctoral)

The Agricultural Research Division of American Cyanamid Company has along-standing and highly successful commitment to the discovery and develop-ment of products to improve worldwide crop and livestock production. We aregrowing rapidly and currently have the following opportunities at our laboratoryand experimental farm complex ideally located near Princeton, one hour fromNew York City and Philadelphia.Senior Toxicology Program ManagerThe successful candidate will have a PhD in Toxicology or related medical fieldand 3 to 5 years of industrial, government or contract laboratory experience intoxicology. Knowledge of whole animal toxicology is essential. You will design,monitor and review the full range of toxicity testing performed in-house oron-contract for EPA and FDA registrations of pesticides and animal drugs.Postdoctoral in Regulatory ToxicologyWe offer a postdoctoral position which requires a PhD in Toxicology or relatedmedical field.American Cyanamid offers a competitive compensation and benefits package.For prompt and confidential consideration, please forward your resume andsalary history, indicating the position of your specific interest, to theEmployment Office, Dept. SC-55, American Cyanamid Company, AgriculturalResearch Division, P.O. Box 400, Princeton, New Jersey 08540. An EqualOpportunity Employer, M/F/H/V.

~! CVA iVAl MD

THE COMMITMENT GROWS EVERY DAY.

Ph.D. SCIENTISTS

Molecular and Cell Biology Research

E _J

For more than a century, scientists at ELI LILLY AND COMPANY have developedinnovative, high quality pharmaceutical products. Lilly invests over $500 million annuallyin research-and-development programs. More than 3,000 scientists at the company'sLilly Research Laboratories are pursuing creative research programs that involve manyimportant health care needs.

lb further build its research capabilities, Lilly is seeking self-motivated, innovativescientists to plan, organize, and manage programs for the Molecular and Cell BiologyDivision.The ideal candidates will have a Ph.D. in biochemistry or molecular biology and at

least two years of postdoctoral research experience in one of the following areas:* Receptor cloning and/or study of mechanisms that modulate receptor response toLigand binding.

* Signal transduction downstream from a receptor through G-proteins, kinases andthe like.

* Transcriptional regulation of receptor genes.In addition, these scientists must have the leadership capabilities needed-technical,

communication, interpersonal, and organizational skills-to build a research program.Eli Lilly and Company is committed to scientific excellence. Lilly provides a stimu-

lating professional atmosphere with many opportunities for collaborative, multidiscipli-nary research. The company offers an attractive total compensation program. Entrylevel and salarywill be based upon each candidate's experience.For prompt consideration, please forward your curriculum vitae to:

John W. Crooks, ManagerPh.D. Recruitment (MCB)Eli ily and CompanyLily Corporate CenterIndianapolis, hIdiana 46285

Senior Research BiologistFMC CORPORATION, a Fortune 150 leader in the field ofAgricultural Chemical Research, is looking for a SeniorResearch Biologist to support our insecticide research.This position will be responsible for the laboratoryprofiling of potential insecticide field candidates, in-cluding test design, result interpretation and follow-uptesting. This individual will also participate in theselection and recommendation of candidate insecti-cides for initial field testing.As Research Biologist you will be responsible for designand coordination of FMC's field screening and fieldevaluation program on a worldwide basis including theanalysis of field results and the preparation of productprofiles prior to hand-off to full commercial development.In addition, the position offers staff supervisory, safetyand security responsibilities. Individual will also havethe opportunity to participate in frequent presentationsto management.Job candidates must possess a PhD in Entomologywith 3-5 years post-PhD industry experience desirable,including experience conducting field trials involvingmajor pest crop market segment. Individual shouldalso be familiar with the strengths and weaknesses ofcommercial insecticides.FMC offers an R & D center in a prime location, challeng-ing work, and excellent benefits and a salary commen-surate with Your experience Please forward your resumeto: Melody Evans, lDpt. 89s24 FMC CORPORATION,Chemical R & D Center, Box 8, Princeton, NJ 08543.Females are encouraged to apply. Equal OpportunityEmployer, M/F.

fMC®

Associate Director/DirectorRegulatory Affairs

Merck, Sharp and Dohme Research Laboratories, the worldleader in Pharmaceutical Research, is seeking an experiencedscientist for the position of Associate Director/Director for itsRegulatory Affairs Department in Blue Bell, PA. The successfulcandidate will have an M.D. or Ph.D and possess 5 to 10 yearsscientific experience In at least two of the following areas:Molecular Biology, Virology, Vaccine Development, QualityControl, Clinical Infectious Disease or Regulatory Liaison.Major responsibilities will include liaison with regulatory agen-cies worldwide regarding a wide range of Issues involving vac-cines, biologicals and anti-virals, providing the Company withinput regarding worldwide regulatory requirements, and direc-ting our research laboratories in meeting these requirements.Merck offers excellent salary opportunities and a benefitsprogram that includes a tax sheltered income program, grouplife Insurance, major medical and dental coverage, educa-tional assistance and relocation. Our facilities are located inan attractive suburban Philadelphia area.Interested candidates should submit their resume and salaryrequirements in complete confidence to:

Janet E. Mama (BL1-1)MERCK SHARP & DOHMERESEARCH LABORATORIES

Department 89B-4West Point, PA 19486

EEOIAA/V/H Employer_

L

I

The growth and development of Abbott Laboratories over thelast 101 years has been an exciting process. We've achieved ourworld leadership position through aggressive and vell-fundedresearch in diverse medical areas. Our Pharmaceutical ProductsDivision is one such area where discoveries and innovations areconstantly being made.

We are seeking a Ph.D. level behavoral pharmacologist to becomepart of an interdisciplinary team which seeks to identify noveltherapeutic agents for disorders of cognitive function. Thesuccessful candidate vwll work in an environment committed toresearch in CNS therapeutic agents, using the most advancedapproaches in neurobiology and chemistry to achieve these goals.A minimum of 2 years postdoctoral experience, and a record ofdemonstrated scientific achievement are required. Previousindustrial experience and expertise in behavioral testing relatedto cognitive function are highly desirable.In addition to excellent salaries and a benefits package thatincludes profit sharing and a stock retirement plan, we offer abeautiful suburban location approximately 30 miles north ofChicago. For consideration, please send your resume with salaryhistory to: Paricia Hand, Cowporate Placeme, Dept.SCI/5-12, Job #0001, Abbott Laborabtoes, I AbbolPk Road, Abbott Park, IL 600". (To facilitate handlingyour resume, please indicate Job number on your cover letter orresume.) Abbott is an Affirrative Action Enployer.

ABBOTI I LABORATORIES_ ~~~Quality

Health CareWorldwide

18s8-1989

PENNSTATE~ The Pennsylvania State University

College of Medicine

NEUROSCIENCE RESEARCHIN ANESTHESIA

The Department of Anesthesia of The Pennsylvania State University College ofMedicine and the University Hospital of The Milton S. Hershey Medical Center isinviting applications for a research faculty position to begin in the Summer or Fallof 1989. The Department presently has four areas of concentration in researchrelated to physiology and pharmacology of the anesthestic state: includingcardiovascular, pulmonary, neurophysiological and neuropharmacological areas.We are seeking candidates with a Ph.D. or M.D. qualification with substantial postdoctoral experience in one or more of the following areas: mechanisms of drugaction, neurotransmitters, membrane receptors, signal transduction, ion-chan-nels, and mechanisms of consciousness. We are particularly interested incandidates who are able to relate their research to the questions of mechanisms ofpain and anesthesia. Significant research accomplishment and demonstratedability to obtain independent funding are essential. Excellent opportunities exist forresearch collaboration and a joint appointment in a basic science department andparticipation in the Neuroscience Program.

Applicants should submit, prior to May 26, 1989, curriculum vitae, reprints,statement of current and planned research interests, and names of at least threereferences to:

Jullen F. Blebuyek, M.B., D.Phil.Eric A. Walker, Professor and Chairman

Department of AnesthesiaTHE PENNSYLVNIA STATE UNIVERSITY

COLLEGE OF MEDICINETHE MILTON S. HERSHEY MEDICAL CENTER

P.O. Box 850Hershey, PA 17033

Equal Opportunity/Affirmadve Action Employer

DEPARTMENT OF SURGERYPOSTDOCTORAL RESEARCH FELLOWSHIPS

METROHEALTH MEDICAL CENTERCASE WESTERN RESERVE UNIVERSITY

The Surgery Department at MMC/CWRU announces the availabil-ity, beginning July 1, 1989, of several Postdoctoral (M.D. and/orPh.D.) research fellowships.A fundamental goal of basic research in the Surgery Department isthe application of basic biochemical, immunological, biophysical,and morphological methods to important biological questionsrelated to the surgical disciplines. Special areas of methodologycurrently emphasized in the Department include: a wide range offluorescence methods (steady-state, lifetime, polarization, FRAP,phosphorescence), basic immunology and cellular immunology,differential scanning calorimetry, and FPLC and HPLC protein,peptide, and phospholipid isolation and characterization. Exten-sive facilities also exist in the Department for tissue culture andbasic molecular biological studies.Applicants experienced in biophysical chemistry, membrane bio-physics, spectroscopy, immunology, and molecular biology whoare interested in applying these disciplines to model as well asbiological systems are encouraged to apply. Clinically trainedapplicants interested in gaining the expertise to apply basicmethodology to biomedical problems should also consider apply-ing. Specific areas of research will depend on the Fellow's interestsas well as those of the Department. Substantial independence inthe execution and development of research problems will beafforded each fellow. Stipends are approx. $27,000. Call (216)459-4456 for more detailed information.MetroHealth Medical Center & Case Western Reserve Universityare both Equal Opportunity Employers which encourage appli-cants from qualified minority groups and women.

CNS PharmacologyPostdoctoral FellowshipPfizer Pharmaceuticals

A postdoctoral fellowship in CNS pharmacologyis now available in our New Drug Developmentgroup located in New York City. As a member ofa multidisciplinary project team, you will havethe opportunity to apply pharmacologic prin-ciples to the preclinical and clinical develop-ment of new drugs. The fellowship covers a 1-2 year period. Qualified individuals will havecompleted all requirements for the doctoraldegree and have no more than one year of post-doctoral (non-industry) experience. For furtherinformation contact: Charlene Mirett, AssociatePersonnel Manager, Pfizer Pharmaceuticals, 235East 42nd Street, New York, NY 10017. Anequal opportunity employer.

El-

Smith Kline & French, a leader in Phanraceutical Researb, hasexcting opportunities for Scientists to join iks exanding ProteinBiochemistry Department. The selected individuals wil design,conduct and interpret experinents invoving the purificaton andcharacterization of vaccine, diagnostic and therapeutic proteincandidates as part of our broad programs in the new research areaof biopharmaceuticals.The successful candidate(s) will have:* BS/MS in Biochemistiy or Chemistry with 2+ yean laboratory

experience in protein purification and characterization.* Experience in column chromatography inciding HPLC, FPLC,

etc.* Experience in state-of-the-art techniques in protein analysis

induding SDS-PAGE, Westem blotting and t1A* Excellent oral and written communication skills.* High motivation with the ability to work independently and as a

team member.Our beautiful, new reseah facility is located in suburbanPhiladelphia, near Valley Foige. Smith Kline & French provides astimulating and challenging envronment with opportunity forprofessional growth. We offer an atracve compensation andbenefits package. For confdental comsideration, please forwardyour resume to: N. Hasson, HOIOS, Smith Kline & FrenchLaboratories Research & Develpment, P.O. Box 1539, King ofPrussia, PA 19406.0939. We are an Equal Opportunity Employer,M/F/H/V. _~A

BOEHRINGER INGELHEIM PHARMACEUTICALS, Inc. isengaged in the discovery, development, manufacture and marketingof novel therapeutic agents. The following position is available inthe department of Drug Metabolism and Pharmacokinetics at ourResearch and Development Center, located in DANBURY, CT.

This position is responsible for performing the followingactivities:

* Developing new methods for quantitation ofcompounds inplasma and tissue.

* Preparing qualitative comparisons of metabolite profiles invarious species.

* Isolating metabolites for identification.* Developing isolation methods for metabolites labeled with

trace radioactivity.* Developing clean-up procedures and methods for

quantitation of drugs and metabolites.* Serving as representative for the department on project and

development teams.Requirements include a Bachelor's or Master's Degree in

Analytical Chemistry, Biochemistry or similar discipline with anumber of years related experience. Ability to analyze data,troubleshoot instrumentation and a familiarity with computers. Ex-perience with a variety of chromatographic systems (TLC, HPLC,LC, GC) and isolation, identification and quantitation oftrace com-pounds in complex biological matrixes.

BOEHRINGER INGELHEIM offers a competitive salary andbenefits package including relocation assistance, modern facilitiesand the opportunity to have your contributions recognized. If in-terested, please send your curriculum vitae to Dept. JC-1S-948,BOEHRINGER INGELHEIM PHARMACEUTICALS, Inc., 90 EastRidge, P.O. Box 368, Ridgefield, CT 06877. We are an equal op-portunity employer m/f/h/v.

(j BoehringerIngeiheim

S IEh kb dRnt

CIENCE

N9- a_ ----

_MMAII

bish Er_ S

JUNE 16, 1989This issue of SCIENCE highlights a tuming point in science, the point at whichbasic, teoretical science - knowledge of gene regulation and grwth regula-tfon, for example - begins to yield prctical benefits to manind.The issue concentrates on what is being done with the technology and thepotential for the futurp rather than on the tchnology if. Fr example:* How geneticaly-altered species of plants, animals and bactena will transform

the worfds agriculture and the pharmaceuical industry.* How scientists are developing the capabiit to precisely inbduce changes

into desired genes and to restore gene functon in ways that will revolutionizegene therapy.

This issue will be referred to, discussed, and retlaned. Lead articles are listedbelow:TopicsHomologous Recombination Genetically Engineeredin Mammalian Systems BacteriaPerspectives in Genetically Genetic EngineeringEnoneered Plants of Flamentous FungiPerpecties in GeneticallyEngineered Animals

Bonus: Full page ads In this issue will also be studiedby Harvey Research

DON'T MISS THIS EXCEPTIONALOPPORTUNITY TADVERTISE

YOUR KEY PERSONNEL NEEDS TO150,000 OF YOUR COLLEARUESCall: Gwen Canter, Tlaffc Mana r

(212) 730-1050Closing date: (Camera Ready Material) May 26,1989

NEUROSCIENTISTS

Faculty Positions Open

Tenure-track Appointment. Associate or AssistantProfessor. Rank and salary commensurate with careerdevelopment. Research, service, and teaching.Participate in graduate training program. Minimumrequirements: Ph.D.; 2 years of postdoctoralexperience in neuroscience research; and fundedand/or fundable research program.

Fixed-term Appointment. Research AssistantProfessor or Research Associate. Rank and salarycommensurate with career development. Positionfunding and continuation dependent upon extramuralgrant funds. Minimum requirements: Ph.D. withresearch in neuroscience.

Send letter of application, curriculum vitae, and namesof 3 references to: Dr. Carl R. Morgan, Departmentof Anatomy and Cell Biology, East CarolinaUniversity, School of Medicine, Greenville, NC 27834-4354. East Carolina is a constituent institution of theUniversity of North Carolina, an AffumativeAction/Equal Employment Opportunity Employer.Federal law requires proper documentation of identiyand employabiUity at the time of employment It isrequested that this documentation be included withcumrulum vitae. Applications should be received by16 June 1989.

POSITIONS OPEN

POSTDOCTORAL POSMON available immedi-ately to study the structure-function relationships of theglycoprotein of feline immunodeficiency virus (FIV).Applicants with experience in recombinant DNA meth-odologies, particularly in the construction and screeningof genomic and cDNA libraries preferred. Annual salaryrange $20,000 to $25,000, dependent upon experience.Please send curriculum vitae and names of references to:Dr. Edward Stephens, Department of Infectious Dis-eases, College of Veterinary Medicine, Box J-137, J.Hillis Miller Health Center, University of Florida,Gainesville, FL 36210-0137. The University of Floridais an Equal Opportunity/Afirmative Action Employer.

POSTDOCTORAL POSMON IN BIO-CHEMICAL PHARMACOLOGY for recent Ph.D.interested in the biochemical modulation of anticancerdrug activity. Research in the use of nucleoside transportinhibitors to increase the selectivity of antimetabolitesagainst human tumors growing in culture or as xeno-grafts in mice. [J. Biol. Chem. 263, 19419 (1989)]Salary $22,000 to $25,000. Send curriculum vitae andnames of four referees to: Judith A. Belt, Ph.D., De-partment of Biochemical Pharmacology, St. JudcChildren's Research Hospital, 332 North Lauder-dalc, P.O. Box 318, Memphis, TN 38101.An Equal Opportunity/Afirmative Action Employer.

POSTDOCTORAL POSMONIN NEUROBIOLOGY

Associate needed for study of axon growth and syn-apse formation. Send curriculum vitae, a description ofexperience and career goals, and namnes of three refer-ences to: Dr. Kenneth J. Muller, Department ofPhysiology and Biophysics, University of MiamiSchool of Mcdicine, P.O. Box 016430, Miami, FL33101. For further information, call: 305-547-6821.An Equal Opportunity/Affirmative Action Employer.

POSTDOCTORAL POSITIONS available imme-diately to study biochemical and molecular mechanismsof chemical carcinogenesis. Projects in several areas areavailable using mouse epidermis in vivo and/or keratino-cyte culture models including: (i) DNA-repair mecha-nisms in keratimocytes m relation to differentiation stageand type and location of DNA lesion; (ii) role ofoxidation in epidermal toxicity and skin tumor promo-tion bv anthrones; and (iii) role of epidermal proteinkinase C and other signal transducuon pathways inmediating genetic differences in gene expression andtumor promotion in inbred mouse strains. Backgroundin enzymology, free radical biochemistry, or molecularbiology techniques would be helpful. Salary negotiable.Send curriculum vitae and the names and addresses ofthree refcrences to: Dr. John DiGiovanni, Universityof Tcxas M. D. Anderson Science Park, RDivision, P.O. Box 389, Smithville, TX 78957. TheUniversity of Texas M. D. Anderson Cancer Center is anAfirmative Action/Equal Opportunity Employer.

POSTDOCTORAL RESEARCH ASSOCIATEPosition available immediately for Ph.D. with strong

background in mammalian cell biology/membrane bio-chemistry to join a research project investigating mam-mary epithelial cell differentiation, under the direction ofDr. Kam Thompson. Emphasis will be placed ondetermining if 'tage-specific markers for nor mamma-ry epitheli cell evefopment can be defined.Send curriculum vitae with complete reference infor-

mation to: Children's Hospital Oakland-ResarchInstitute, Human Resources Department 1455, 74752nd Street, Oaldand, CA 946Mo. Equal OpportunityEmployer.

RESEARCH ASSOCIATE with graduate degree orexperienced RESEARCH ASSISTANT with B.S. orA.B. and knowledge of cell culture techniques, blottingand other molecular biology procedures, and/or proteinchemistry. Ongoing research program involves mecha-nisms of promotion of biosynthesis of inhibitors ofhemostatic enzymes: including specific mRNA produc-tion by human cells, analysis of certain plasma proteins,using functional and analytical techniques including co-agulation and enzymatic assays, and gel electrophoresis.Salary commensurate with qualifications; immediateopening. Children's Hoial Rescarch Foundation(CBRP), Etland and Becsda Avenues, Cincnnati,OH 45229 (Dr. V. H. Donaldson). Telephone: 513-5594244. CHRF is an Equal Opportunity Employer.

738

POSTDOCTORAL POSITIONS available for re-cent Ph.D.'s to participate in an active research programon the structure, regulation and expression of DNArepair genes in human cells. Current efforts focus on thetranscnptional expression of DNA repair genes and theintracellular localization ofDNA repair enzymes in rela-tion to DNA damage and rerir. Submit curriculumvitae and the names of three references to: Dr. MichaelA. Sirover, Fels Institutc for Cancer Rcscarch andMolecular Biology, Temple University School ofMedicine, 3420 North Broad Strect, Philadelphia,PA 19140. An Equal Opportunity/Affirmative AcionEmployer.

POSTDOCTORAL POSITIONS IN INSECTENDOCRINOLOGY available 1 June 1989 to study(i) molecular aspects of a juvenile hormone receptor genein Drosophila (T. Wilson) or (ii) ecdysone regulation ofmale accessory gland genes in Tenebrio (G. Happ).Experience in molecular biology or biochemistrv pre-ferred. Send curriculum vitae to either of the above at:Depuartment ofZoology, University ofVermont, Bur-lington, VT 05405. An Equal Opportunity/AfirmativeAction Employer.

POSTDOCTORAL RESEARCH position avail-able to work on the molecular cell biology of phagocyteoxidant and anti-oxidant systems. A Ph.D. or equivalentin molecular biology or a related field is preferred.Contact: Dr. Peter E. Newburger, Departments ofPediatrics and Molecular Genetics-Microbiology,University ofMassachusetts Medical School, Worces-ter, MA 01655. Telephonc: 508-8564225. The Uni-versity ofMassachusetts is an Affirmative Action/Equal Oppor-tunity Employer.

POSTDOCTORAL RESEARCH ASSOCIATEA position is available at the level of postdoctoral

research associate to teach medical physiology to first-year mcdical, dental, and pharmacv students, to teachgraduate level coursc in physiology, to conduct interdis-ciplinary resarch on the central nervous system effects ofbacterial products and immune response modifiers, andto direct support personnel. Other special requirementsare: knowledge and experience in use of HPLC and gaschromatography, knowlcdge and experience in use ofmass spectrometry, experience in microbiological tech-niques including growth of bacteria and isolationof various bactenal products and relevant publications.The annual salary will be $24,000. Applicants witha Ph.D. degree send curriculum vitae and the names ofthree references to: Jack Hilzheim, Tennessec JobServicc, 1309 Poplar, Memphis, TN 38104. An EqualOpportunity Affirmative Action Employer. Minorities andwomen are encouraged to apply.

POSTDOCTORAL RESEARCHERREGULATION OF I-A EXPRESSIONTHE OHIO STATE UNIVERSITY

Postdoctoral position available 1 Julv 1989 to studyregulation ofMHC Class II exprcssion that is controlledby the Bcg gene. Applicants should have a Ph.D. degreewith experience in membrane biochemistry, molecularbiology, immunology or mnicrobial-host cell interactions.Please send a copy ofyour curriculum vitae and names ofthree references to: Dr. Bruce S. Zwilling, Departmentof Microbiology, The Ohio State University, 484West 12th Avenue, Columbus, OH 43210. The OhioState University is an Affirmative Action/Equal OpportunityEmployer and specifically invites and encourages minority andwomen applicants.

The Department ofChemistry, Yale University, invitesapplications for a tenured position at the level of PRO-FESSOR in the area oforganic chemistry, especially as itrelates with other areas of chemistry such as theory,materials science, and biochemistry. We are conducting aparallel search for those interested specifically in syntheticorganic chemistry. An outstanding, established teacher-scholar is sought whose research interests will comple-ment those of the current staff. The position is to beoccupied in the academic year 1989 to 1990.

Applicants should submit curriculum vitae, and a listof publications to: Professor Peter B. Moore, Chair-man, Department ofChemistry, Yale Univcrsity, 225Prosect Strcet, P.O. Box 6666, New Haven, CT06511-8118 before June 1989. Yale University is anEqual Opportunity/Affirmative Action Employer.

POSTDOCTORAL RESEARCH IN NEUROBI-OLOGY-The Arizona Research Laboratories (ARL)Division of Neurobiology, a research unit devoted toccllular, developmental, and molecular neurobiology andneuroethology of insects, invites inquiries from potentialpostdoctoral trainees. Applicants should send resume,statement of interests and plans, and names and addressesof three references to: Dr. John G. Hildebrand, Direc-tor, ARL Division of Neurobiology, 611 Gould-Simpson Building, University of Arizona, Tucson,AZ 85721. The University ofArizona is an Equal Opportu-nity/Affirmative Action Employer.

PROTEIN ANDNUCLEIC ACID BIOCHEMIST

HOWARD HUGHESMEDICAL INSTlTUTE AT THE

MASSACHUSEITS GENERAL HOSPITALA unique and exciting opportunity is open for an

appropriately qualified biochemist to operate a Micro-chemical Facilitv equipped with state-of-the-art instru-mentation. Functions of the facility include proteinmicrosequencing, peptide and nucleic acid synthesis andcharacternzations. The studies involve the design of pro-tein analogs of important hormone ligands and compo-nents of nuclear transcription factors. In addition tosupervision of the facility, opportunities exist for inde-pendent and/or collaborative research on the structuraland functional aspects of bioactive proteins. Prerequisitesare a M.S. or Ph.D. degree in biochemistry. Top salaryand extensive benefits are available. Send resume to: JoelF. Habener, M.D., Howard Hughes Medical Insti-tute, Wcllman 3, Massachusetts General Hospital,Boston, MA 02114.

RESEARCH ASSOCIATES AND Ph.D.'sIN MARINE SCIENCES

Several positions on: production and export ofphyto-plankton to (a) larval and adult scallops and (b) codlarvae (with L. Legendre); transport/feeding/survival of(c) scallop larvae (with J. J. Dodson) and (d) cod larvae(with L. Fortier); (e) aquaculture of scallops in openwaters (with J. H. Himmelman); (f) development ofclonal antibody for identification of scallop larvae (withJ. J. Dodson); (g) small-scale hydrodynamics of larvalscallop settlement (with E. Bourget). Research asso-ciates: Ph.D. preferably with postdoctoral experience[except (g): research engineer]. Laval University isFrench-speaking, but research may be conducted inEnglish. Scnd curriculum vitae, representative reprints,names, addresses, and telephone numbers of threereferees, and specify a firm date of availability, to:GIROQ, Departement de biologie, Univcrsite Laval,Qubecc, Quebc, Canada, GlK 7P4.

RESEARCHERAINFECTIOUS DISEASE IM-MUNOLOGY to perform research on projects relatedto T cell responses to bacterial polysaccharides based onprevious experience with tissue culture. Work relates toTcell responses to bacteria, namely a host's response topolysaccharide antigens. Will investigate properties ofTcells which respond to human bacterium pathogen Bacte-roides fragilis. VWill work in isolation of clones ofl olysac-charide-specific T cells. Must use previous expenence inT cell manipulation and in animal models of infection to:expand T cells responsive to polysaccharide in vitro;clone T cells which respond to polysaccharide; character-ize those cells; define which cels are present in abscessesmice develop in response organism; measure release oflymphokines (mediators) from immune cells; and definetheir role in affecting response. Will instruct other re-search associates in growth of antigen-specific T cellclones involving cloning and characterization of herpessimplex virus-specific T cells. Candidate must possess anM.D. in medcine together with 1 year in positionoffered. Must also possess demonstrated expertise inproducing and maintaining murine and human T cellslines and clones; demonstrated expertise in in vivotransfer of cells; demonstrated expertise in performingresearch involving small animal laboratory techniques;demonstrated expertise in cell culture techniques; dem-onstrated expertise in functional and biochemical charac-terizations of T cell products. Salary is $35,000 per yearfor 5-day, 40-hour work week. R6sum6s only to: Massa-chusetts Department of Employment and Training,Charles F. Hurley Building, 19 Staniford Street,Boston, MA 02114. Job Order #9550. Equal Opportu-nity Employer.

SCIENCE, VOL. 244

POSITIONS OPEN POSITIONS OPEN

--A*, 122--L-IUM ARRISOL;AW EMEI I T-01

San Antonio, Texas

TOXICOLOGY

MAMMALIANTOXICOLOGISTFMC Corporation, a Fortune 150 internationalmachinery and chemical corporation has anopening for a Mammalian Toxicologist at ourChemical Research and Development Centerlocated in Princeton, NJ. Responsibilities willinclude evaluating and interpreting data frommammalian toxicology programs and preparingrisk assessments; assisting in the compilationand dissemination of technical information;acting as study director/study monitor forMammalian Toxicology programs; assistingregistration specialists with toxicology studiesnecessary for registration of industrial andagricultural chemicals; and preparing MSDS'sand product literature.Position requires an MS/PhD degree in Tox-icology or related field, and/or up to 2 years in-dustrial experience. FMC offers excellent salaryand benefits package. Please send resume withsalary requirements to: FMC CORPORATION,Dept. 89-27, P.O. Box 8, Princeton, NJ 08543.ATTN: Personnel Manager. Equal OpportunityEmployer, M/F.

fMC®_

Southwest Research Institute has an immediate opening for a senior professional to head its Department ofBiosciences and Bioengineering.The Department is currently engaged in contract research and development work for both industrial and goven-

ment clients in the general areas of biomedical instrumentation, field and clinical evaluations, human factors andperformance assessment, toxicology and applied pharmacology. These activities are supported by well-establishedinstitute divisions in such fields as chemistry and chemical engineering, engineering and materials sciences, automa-tion and data systems, and others.

Applicants should possess advanced degrees in bioengineering and/or biosciences related to the above mentionedareas and have a strong background in medical and physiological effects. Applicants should also possess superiormanagement skills and leadership ability as well as a proven track record in contract research and development.Knowledge of and experience with regulatory agencies would be considered a positive factor.

Southwest Research Institute is a nonprofit research and development organization conducting contract researchand development at a current annual volume in excess of $180M, with a current regular staff of over 2,300. Anexcellent benefits program is available for all regular staff and our salary structure is highly competitive.Resumes may be forwarded in complete confidence to: Mr. C.J. Luna, Sr. Personnel Specialist, SouthwestResearch Institute, Personnel Dept. #373, P.O Drawer 28510, 6220 Culebra Road, San Antonio,Texas 78228 or call collect (512) 522-3378. Equal Opportunity/Affirmative Action Employer.

S k IRneSouthwestR ~~~~~ResearchInstitute

POSITIONS OPEN

Need one RESEARCH ASSOCIATE to performstudies on maternal drug abuse and neurochemical devel-opment of offspring. Contact: Dr. Theodore A. Slot-kin, Department of Pharmacology, Box 3813, DukeUniversity Medical Center, Durham, NC 27710.Duke University is an Equal Opportunity/Affirmative ActionEmployer.

SENIOR CHEMIST-Responsibilities in-clude supervising the research and developmentof new inks and related materials in connectionwith the company's ink projects; characterizingand defining suitable inks for print testing;checking compatibilities and setting up analyticalquality control methods. Oversee the work ofthree chemists. An applicant must have (i) aMaster of Science degree with a concentration ineither inorganic or physical chemistry, and (ii)either 2 years ofexperience as a senior chemist or5 years of experience in physical or inorganicchemistrv. Also required is a strong backgroundin and knowledge of organic chemistry, includ-ing dye and so[vent chemistry; a strong back-ground in and knowledge of analytical chemis-try, including HPLC, GC, FrIR, UV-VIS andAA, and also including fluorescent or colorime-try; and a strong background in and knowledgeof surface chemistry and solution chemistry.Salary range: $47,000 to $53,000 per year. Sendresume to: Job Service Technical Unit, Con-necticut Department of Labor, 200 FoilyBrook Boulevard, Wethersfield, CT 06109.Refer to job order #3042844.

STUDY DIRECTORTOXICOLOGY

Hazleton Laboratories America, Inc., has an opportu-nity for a toxicologist with a strong scientific backgroundand excellent communication skills. Responsibilities in-clude:* Serve as study director on toxicology studies* Prepare protocols, study schedules, resource estimates* Prepares interim and final reports* Communicates and consults with clients* Provides technical/scientific expertise for other areas

Requirements include the following:* Ph.D. in toxicology or a related science* Three years of experience in the field* Effective client communication skillsSend letter of introduction and r6sum6 to: Personnel

Manager, Hazleton Laboratories, P.O. Box 7545,Madison, WI 53707.

An Equal Opportunity Employer.

THEORETICAL NEUROBIOLOGYThe Neurosciences Institute (NSI) invites applications

for positions as INSTITUTE FELLOWS IN THEO-RETICAL NEUROBIOLOGY. The NSI supports anin-house research program dedicated to developing ex-perinentally testable theoretical models of neural sys-tems. Current models include simulations of pharmaco-logical effects on neuronal networks, the design of net-work automata, and analysis of visual systems. Advancedsupercomputer facilities are available.

Institute Fellows are appointed for 2 years with thepossibility of renewal and receive stipends that dependon qualifications and experience. Applicants should be atthe postdoctoral or assistant professor level and musthave a background in experimental or theoretical neuro-science or related fields.The NSI is an independent organization located on the

campus of The Rockefeller University in New York Citv.The NSI serves as the home of the NeurosciencesResearch Program and is ap international center of studyand research for distinguished visiting neuroscientists.Fellows have opportunities to use the Institute's exten-sive facilities and to interact with visiting scientists.

Applicants should send a short statement of researchinterests, curriculum vitae, and the names of three refer-ences to: Dr. W. Einar Gall, Research Director, TheNeurosciences Institute, 1230 York Avenue, NcwYork, NY 10021.

SCIENCE, VOL. 244

Molecular VirologistThe Department of Medical Microbiology andInfectious Diseases, University of Alberta invitesapplications for a faculty position in virology.

Applicants should have a PhD degree with atleast three years of postdoctoral research exper-ience.The successful candidate is expected to de-velop a strong extramurally funded research pro-gram in the area of molecular virology. Prioritywill be given to individuals with expertise in theapplication of molecular approaches to the un-derstanding of the pathogenesis of retroviral dis-eases. Up to 75% of time will be devoted to re-search, with the remaining time available forparticipation in undergraduate and graduateteaching, including the supervision of graduatestudents. Salary and rank will be commensuratewith training and experience. Annual salaryrange for 1988-89: Asst. Prof. C$33,144 toCS47,280; Assoc. Prof. CS41,390 to C$59,534;Prof. CS52,730-. The successful candidate will beeligible to apply for salary and establishmentfunding support by competitive application fromthe Alberta Heritage Foundation for Medical Re-search.In accordance with Conadion immigration re-quirements, priority will be given to Canadiancitizens and permanent residents of Canada.

The closing date for application is June 30, 1989.

Please send applications consisting of detailedcurriculum vitae, statement of research program,reprints of the applicant's five most significantpublications and the names of three referees to:

Dr. David L. J. Tyrrell, Chairman, Department ofMedical Microbiology and Infectious Diseases,1-41 Medical Sciences Building, the University ofAlberta, Edmonton, Alberta, T6G 2H7, Canada.

The University of Alberta is committed to theprinciple of equity in employment.

HUGH KNOWLES CHAIRSAUDIOLOGY AND HEARING SCIENCE

NORTHWESTERN UNIVERSITYNorthwestern University announces the estab-lishment of two endowed chairs, the HughKnowles Chair in Audiology and the HughKnowles Chair in Hearing Science. Each Chair,funded by a generous gift from Knowles Elec-tronics, Inc., will be filled by faculty of distin-guished scholarly achievement or unusual prom-ise and developing international reputation. Ap-plicants for the Audiology Chair should be Ph.D.scholars with an interest in auditory systemfunction, having quantitative background (e.g.,bioengineering, computer science or psycho-acoustics). Applicants for the Hearing ScienceChair should be Ph.D. or M.D. scholars withaccomplishments in basic or clinical neurosci-ence and an interest in either higher nervoussystem function or neurobiology of the peripher-al auditory system. These positions will be filledat either the full or associate professor level.Generous start-up funds, laboratory space and acompetitive salary are provided.Applications and nominations are invited. Re-view of applications will begin immediately, butthese positions will remain available until filled.Please send curriculum vitae along with a letterof interest to:

Chair, Search CommitteeAudiology and Hearing Impairment Program

Northwestern University2299 Sheridan RoadEvanston, IL 60208

Northwestern University is an EO/AA Employer.Hiring is contingent upon eligibility to

work in the United States.

MANAGER,COLLABORATIVERESEARCH

We are a growing International division of Baxter Healthcare Cor-poration. Today as we strive to meet new long-term objectives, anoutstanding opportunity is offered at one of our Deerfield locations.

We have need of a Scientist to manage outside, contracted researchprograms. These programs cover a broad range of nutrition research,from basic science to clinical studies and are international in scope.The successful candidate will have a Ph.D. in biochemistry, nutrition, orphysiology and from 1-3 years of postdoctoral experience. Experiencein metabolism research and some exposure to clinical research aredesirable.A highly competitive salary and comprehensive benefits program is

included in this total package. Immediate attention will be given to thoseindividuals who submit their resumes with salary history and expecta-tions. Please send resume to: Baxter Healthcare Corporation, c/oBentley, Barnes & Lynn, Inc., 420 N. Wabash Ave., Dept. S-0232,Chicago, IL 60611. (All resumes will be forwarded unopened andimmediately to Baxter.) Equal Opportunity Employer.

BaxterL

74-0

1 -T UI BS/MS SCIENTISTSFauw,wmem m , POLYMER CHEMIS RY AND DRUG DELIVERYNORTH A ITMU R ImEuIE l| Amgen, a rapidly developing biopharmaceutical company, is currently seeking two

IE3F 1~N~-_PK F pPM c $TES innovative BS/MS level scientists to contribute to our on-going research efforts in the

Task: to initiate work on policy problems associated development of novel drug delivery systems for protein and peptide pharmaceuticals.with the use, development and conservation of thenatural resources, especially savanna land, of RESEARCH ASSOCIATE -PIARMACEUTICSNorthem Australia. Oa8l8caeons: A PhD in eco- Dept. #393nomics, agricultural economics, or natural resource Qualified candidates for this position must have a BS or MS in Chemistry or a relatedmanagement and experience in the analysis of

field and some experience in polymer chemistry and drug delivery. Experience inresource related problems is essential. Postgradu-ate research experience in the relationships between spray coatings and micro-encapsulation for drug delivery systems or devices issocial and ecological sciences would be an advan- hiqhly desirable.tage. Pest: Full time research, available January1990, location, Darwin, Australia. Secondmentsfrom other institutions considered. Details: A short RESEARCH ASSOCIATE - DRUGDELIVERYstatement of proposed research is to be submitted Dept #394with the application. Further details from the Execu- .394tive Director, NARU, PO Box 41321, Casuarina, NT Candidates for this position must have a BS or MS in Chemistry or a related discipline0811, Phone (089) 275 688, FAX (089) 450 752. and experience with lipid vesicles and emulsion micro-emulsion technology.Closing date: 30 June 1989. Ref: PA 30.3.3. Experience with one or more of the following techniques - FTIR. Gel Electro-

Senior Research Fellow; AS42,582-AS5,619 p.a.; ohoresis. HPLC. light scattering. NMR and DSC - is desirable.Research Fellow; A$30,737-AS40,100 p.a.; Post- Amgen offers the unique opportunity to contribute to challenging and exciting researchdoctoral Fellow Grade 1 (fixed point); AS26,617- programs on the leading edge of pharmaceutical science. Amgen also offers an excellentAS3o,360 p.a. APPOINTMENT: Senior Research compensation and benefits package as well as an attractive location northwest of LosFellow/Research Fellow up to three years, possibility Aglsof extension to five years; Postdoctoral Fellow Anqeles.normally two years, possibility of extension to threeyears. APPLICATIONS should be submitted in dupli- Qualfied applicants should send a resume or c.v.. in confidence. to:cate to the Registrar, The Australian National Uni- AMGEN, INC.versity, GPO Box 4, Canberra ACT 2601, Australia,quoting reference number and including curriculum Recruitment, (specify Dept. #)vitae, list of publications and names of at least three 1900 Oak Terrace Lanereferees. The University reserves the right not to T Oaksmake an appointment or to appoint by invitation a Thousand Oaksany time. Further information is available from the CA 91320Registrar. lll Eaualu^ 1 | tTHE UNIVERSITYISAN EQUAL OPPORTUNITY EMPLOYER. Emplover

CardovsulrToxicology ResearchZ ] ~~~~~Formore than a century, scientists at ELI LILLYAND COMPANY have developed

innovative, high quahity pharmaceufical products. Lilly invests over $500 million annuallyin research-and-development programs. More than 3,000 scientists at the company'sLilly Research Laiboratories are pursuing creative research programs that involve manyimportant health care needs.

OpwtwftEMOOM To further build its research capabilities, Lilly is seeking a self-motivated, innovativeKIOP6tUUt7UhIIO~f scientist in the Cardivaswular PhyIology/Pharmacology area:

* To direct laboratory efforts investigating the cardiac and hemodynamic effects of newpharmaceuticals and agrichemicals in the context of toxicology research and safetyassessment, utilizng a variety of conscious animal models and state-of-the-artinstrumentation.

* Must have Ph.D. in pharmacology, physiology, or a related discipline. (Postdoctoraltraning is preferable, but not essential.)

. Laboratory experience in the design, execution, and analysis of hemodynamic param-eters in whole animal preparations is required.

. Experience with the programming or use of laboratory computers is necessary.In addition, this scientist must have the leadership capailities needed-technical,

communication, interpersonal, and organizational skills-to build a research program.Eli Lilly and Company is committed to scenfic excellence. Lilly provides a stimu-

lating prfessional atmosphere with many opportunities for collaborative, multidiscpli-nary research. The company offers an attractive totalcompensation program. Entrylevel and slary will be based upon each candidate's experience.For prompt consideration, please forward your cwauiadum vitae to:

JohnW.Croo, ManagerPh.D. Recruitment (CTR)Eli illy and Compily Corporate Center

Indianapolis, Indiana 46285

POSITIONS OPEN

SENIOR FACULTY POSMONMOLECULAR BIOLOGIST

The Departncnt ofMolecular Biology and Biochemis-try at Wesleyan University invites applications for atenured position at the associatc or full professor level.The position was made possible in part by a grant to theUniversity from the Howard Hughes Medical Institute.The Molecular Biology and Biochemistry Departmenthas a strong Ph.D. program, complemented by similarprograms inbiology and chemistry. Areas of strength inthe life sciences include molecular, cell and developmen-tal biology, genetics, neurosciences, molecular biophys-ics, and i ch stry.We seek a person of demonstrated scientific accom-

plishmnent who uses molecular genetic approaches tostudy fundamental problems in biology. Further infor-mation may be obtained from: Dr. Lcwis Lukens at203-347-9411, extension 2309. Interested applicantsshould send curriculum vitae, summary of research plans,and names and addresses of five referees to: SearchCommittee, Department of Molecular Biology andBiochemisty, Wesleyan University, Middletown, CT06457.

Wesleyan University is an Equal Opportunity/AfirmativeAction Employer. We encourage applications from minoritycandidates and women.

SENIOR RESEARCH ASSOCIATE for universityin central Ohio to conduct scholarly research in areas ofmolecular spectroscopy and reaction dynamics usingvarious lasers. Publishes articles in peer-reviewed jour-nals. Requires Ph.D. in chemistry or physics and 2 yearsof expenence operating, maintaining, and modifyingNd:YAG, excimer and pulsed dye lasers and use of theselasers in the production of tunable coherent light in theextreme ultraviolet(less than 200 nanometers); 1 year ofexperience operating and maintaining optical mixingcrystals, photo-multipliers and vacuum and air mono-chromators; one or more publications in the area ofmolecular spectroscopy and reaction dynamics in scholar-y joumals. Forty hours per week; 8 a.m. to 5 p.m.;Z29,800 per year. Qualified applicants reply by r6sumrto: C. Bussard, JO#1167300, Ohio Bureau of Em-ployment Services, P.O. Box 1618, Columbus, OH43216.

STABLE ISOTOPESPOSTDOCTORAL POSITIONS

University of California, Santa Barba. Applicationsare invited for two stable isotope postdoctoral positionsavailable 1 July 1989. Research involves studies of themechanisms responsible for the distribution of oxygenand hydrogen isotopes in plants and applications ofstable isotopy of these elements to problems in plantphysiology, physiological ecology and paleoclimatology.For examples, see Plant Physiol. 82, 211, 423 and 428(1986) and Geochim. Cosmochim. Acta 52, 2189 (1988).Training in plant biology desired; no experience withisotopes required. Annual salary: $23,892 to $35,832.Submit r6sume, including discussion of research inter-

ests, and the names, addresses, and telephone numbers ofthree references to: Michael DeNiro, Geological Sci-ences Department, University of California, SantaBarbara, CA 93106. Deadline: 12 June 1989. UCSB isan Equal Opportunity/Afirmative Action Employer. Proof ofU.S. citizenship or eligibility for U.S. employment will berequired prior to employment (IRCA 1986).

VISION SCIENTISTA basic research position in vision science, with joint

appointments in the R. S. Dow Neurological SciencesInstitute and Department of Ophthalmology of GoodSamaritan Hospital and Medical Center is available for aPh.D. of M.D. with research interests at the cellular orsub-cellular level. Generous start-up funds and space arecommitted to this position. Level of appointment depen-dent upon prior research accomplishments. Postdoctoralresearch expenence required. Opportunity exists for in-teraction with the 16 basic neuroscience research labora-tories (four dedicated to vision research) that are affiliat-ed with the R. S. Dow Neurological Sciences Institute,and with clinicians in the Department of Ophthalmolo-g Send curriculum vitae and names of three referencesFy 31 June 1989 to: M. W. Kaplan, Ph.D., Chairman,Vision Scientist Searh Committee, CS. Dow Nes-rological Sciences Institute, Good Samaritan Hospi-tal and Medical Center, 1120 N.W. 20th Avenue,Portland, OR 97209-1595. An Equal OpportunityEmployer.

SENIOR RESEARCH SCIENTIST. Ph.D. in vi-rology/microbiology required. Seeking an cxperienced,highly qualified virologist willing to work with humanimmunodeficicncy virus in a laboratory sctting. Strongmolecular biology background essential with capabilityto develop and carry out AIDS research projects. Pleasesend curnculum vitac and names of three refcrcnces to:Dr. A. E. Friedman-Kien, Department of Microbiolo-gy, New York University Medical Ccnter, 550 FirstAvenue, New York, NY 10016. An Equal OpportunityEmployer M/F.

AWARDS

RESEARCH AWARDSThe International Life Sciences Institute Research

Foundation (ILSI Research Foundation) announces thattwo awards for basic research projects in toxicology andnutrition, each of up to $100,000 over 3 years, will bemade in 1990. Thepurpose of the awards is toencourageinnovative, young investigators in basic biomedical sci-ences to apply mode owldge and techniques tobasic problems related to comparative toxicology orspecific nutritional effects on growth and development.The closing date for applications is 1 September 1989.For further information, write: ILSI Research Founda-tion, 1126 16th Street, NW, Suite 100, Washington,D.C. 20036.

FELLOWSHIPS

POSTDOCTORAL FELLOWSHIPThe Hypertension Research Division at Henry Ford

Hospital is a multi-disciplinary laboratory in the Heartand Vascular Institute, involved in the study of vasoac-tive substances in the regulatnon of blood pressure. Anopportunity is available for a Ph.D. or M.D. within aproductive environment which integrates cardiovascularand renal physiology, biochemistry, pharmacology, mo-lecular biolo and medicine. A variety of projects andexposure to different techniques are available, dependingupon prior research experience or the motivation of theapplicant. Salary and benefits are negotiable dependingupon previous experience. Applicants should send theircurriculum vitae and two references (or "letters of refer-ence") to:

Dr. Oscar A. CarreteroDivision Head

Hypertension Research Division7123 E & R BuildinHenry Ford Hospit

2799 West Grand BoulevardDetroit, MI 48202

ACADEMIC FELLOWSHIPS IN NEONATAL-PERINATAL MEDICINE/CELL AND MOLECU-LAR BIOLOGY. Advanced training in cell and molecu-lar biology integrated with clinical training, leading tocompetence as a physician-scientist with sub-board eligi-bility in neonatal-perinatal medicine is offered in aninnovative 3- to 5-year program. Mentor-based researchtraining is available in: computer-enhanced imaging,developmental gene regulations, molecular biology ofantioxidant systems, infectious agents, inherited disease,and signal transduction, molecular toxicology of oxi-dants, neutrophil biology, protein phosphorylation andprotein phosphatases, pulmonary macrophage biology,and type II pneumocyte biology. Contact: David War-burton, M.D., Academic Training Program in Neona-tal-Perinatal Medicine/Cell and Mo IecuYBiologyDepartment of Pediatrics, USC School of Medicine,Childrens Hospital of Los Angeles, Box #83, 4650Sunset Boulevard, Los Angeles, CA 90027. Tele-phone: 213-669-2101; FAX 213-664-6917.

POSTDOCTORAL FELLOWSHIPS IN MO-LECULAR BIOLOGY at Harvard Medical School.Unexpected opcnings cxist in July 1989 for two individ-uals holding Ph.D. or M.D. degrees for NIH-supportedpostdoctoral training in molecular biology of ion trans-port proteins. Strong backgrounds in biochemistry re-quired. Only U.S. citizens or permanent residents are eligible.Send curriculum vitae and three references to: Dr. BarryM. Brenner, Director, Renal Division, Brigham andWomen's Hospital, 75 Francis Street, Boston, MA02115. HMS/BWH are Equal Opportunity Employers.

Conference on:THE BIOLOGICAL ACTIONS OF

EXTRACELLULAR ATPsponsored by The New York Academy of Sciences

Adam's Mark Hotel, Philadelphia, PA27 to 29 November 1989

For fiuther information: Conference Department,Ihe New York Academy of Sciences, 2 East 63rdStrect, Ncw York, NY 10021. Telephonc 212-838-0230.

FIRST INTERNATIONAL CONFERENCE ONWASTE MINIMIZATION AND CLEAN TECH-NOLOGY: MOVING TOWARD THE 21ST CEN-TURY

Geneva, Switzerland, 29 May to 1Junc 1989. Interna-tional Conference Center. Features plenary sessions,workshops, and technical tours.To register, contact: Ms. M. Mowery, APWA, P.O.

Box 94310, Chicago, IL 60678-4310. Telephone:312-667-2200; FAX: 312-667-2304.

IMAGING IN MEDICINE AND BIOLOGY:CURRENT ISSUES AND PROSPECTS

6 to 8 September 1989Drexcl University

Philadelphia, PennsylvaniaSession topics and lead speakers:

Imaging of the Nervous SystemMonte Buchsbaum, M.D., University of California,

IrvineCell ImlaginLee Maly, Ph.D., University of Pennsylvania

Imnaging of Organ SystemsAlexander Margulis, M.D., University of Califomia,San Francisco

Structural ImagingThomas Budinger, M.D., Ph.D., University of Cali-

fornia, BerkeleyHuman Image Understanding

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