Performance Report 2012 - MedUni Wien · Performance Report 2012 Department of Pathophysiology &...

Performance Report 2012

Department of Pathophysiology &

Allergy Research

Center of Pathophysiology, Infectiology and Immunology

Medical University Vienna

Coordinated by:

Marion Sack

Content Page

Introduction 3

Organigram 7

Personnel 10

Impulsseminare 11

1. Detailed Reports of Divisions 12

1.1. Division for Comparative Immunology and Oncology 12

1.2. Division for Cellular and Molecular Pathophysiology 36

1.3. Division for Immunopathology 58

1.4. Division for Medical Biotechnology 80

1.5. Division for Allergy Research 99

Social Events 109

3

Scientific discovery is never the work of only one person.

Louis Pasteur __________________________________________________________________________

The progress report for 2012 of the Institute of Pathophysiology and Allergy Research (IPA)

shall give a detailed overview on the scientific and academic achievements of our

department. Although not fully manned, the IPA has accomplished very high standards of

internationally-recognized scientific output and academic teaching.

This success was achieved by exemplary teamwork, laudable commitment and a high level

of identification of all IPA members with the major goals of the institute and of the Medical

University of Vienna.

I wish to express my sincere thanks to all who have contributed to the IPA´s remarkable

scientific and teaching achievements and to those who supported us through administrative,

organizational and financial matters as well as the cleaning staff and those taking care of the

animal facility. I also thank all our national and international colleagues and collaborators at

other facilities throughout the world.

I wish everyone the successful continuation of our cooperative teamwork in the future!

Barbara Bohle

Head of the IPA

4

General overview

In 2012, the IPA comprised 20 highly active research groups who worked on both basic and

translational aspects in cellular and molecular pathophysiology, immunopathology,

comparative immunology, oncology, medical biotechnology and allergology.

The excellent scientific results in 2012 are reflected in numerous publications in peer-

reviewed high-impact journals, in research awards and in many contributions to prestigious

scientific national and international meetings. A total sum of 213.3 impact factors were

gained by all members of the IPA in 2012. Figure 1 illustrates the total sum of the IPA´s

impact factors for the period 2004-2012. The drop of the total sum of impact factors in 2012

compared to previous years is explained by the change of counting the impact factors. The

members of the IPA have decided to now count the full impact factor if they are first, last or

corresponding authors. If IPA members are co-authors only 50% of the journal´s impact

factor is counted.

Figure 1

0

100

200

300

400

500

600

2004 2005 2006 2007 2008 2009 2010 2011 2012

tota

l s

um

of

imp

ac

t fa

cto

rs

//

Also in terms of recruiting third party funding and research grants, the members of the IPA

were very successful in 2012. Again, several research projects funded by the Austrian

Science Fund (FWF) and other funding agencies, e.g. the Österreichische Nationalbank, the

medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien as well as the

European Commission, were granted to principal investigators at the IPA. In addition, the

doctoral college “Molecular, Cellular and Clinical Allergology” led by Prof. Winfried Pickl was

implemented by the FWF. Several members of the IPA belong to the faculty of this highly

competitive, multidisciplinary research program, namely Barbara Bohle, Heimo Breiteneder,

Erika Jensen-Jarolim, Margarethe Focke-Teijkl, Beatrice Jahn-Schmid, Karin Hoffmann-

Sommergruber, Rudolf Valenta and Susanne Vrtala. All members of the IPA are highly active

researchers and well embedded in the international fields of their expertise, reflected by

New calculation of IF

5

many successful and long lasting collaborations with national and international research

partners.

The ongoing commitment of the IPA’s members to teaching is reflected by a total sum of

242.12 semester hours for 2012. Hence, the IPA has delivered education of an exceptional

quality to students. The total numbers of semester hours of the members of the IPA held at

the Medical University from 2004-2012 are shown in Figure 2.

Figure 2

0

50

100

150

200

250

300

2004 2005 2006 2007 2008 2009 2010 2011 2012

su

m o

f s

em

es

ter

ho

urs

at

the

MU

V

Figure 3

0

10

20

30

40

50

60

70

2004 2005 2006 2007 2008 2009 2010 2011 2012

tota

l n

um

be

r o

f s

tud

en

ts

Academic teaching of young scientists is an important IPA focus and is demonstrated by the

high number of bachelor, diploma and PhD students at the IPA. In 2012, a total of 112 young

Austrian and international researchers were trained at the IPA. Figure 3 shows the total

numbers of diploma (white circles), PhD (black circles) and bachelor students (black

triangles) in the period 2004-2012.

In addition to the training of students, the IPA was also active in training physicians for

specializations in pathophysiology and immunology. Regular “Impulse Seminars” were

organized by the IPA which can be regarded as advanced training for medical doctors and

students and combined basic research with clinical aspects. Furthermore, members of the

IPA are active in teaching and examining not only at the Medical University but at other

universities, including universities of applied sciences. Several IPA members also act as

reviewers of external diploma and PhD theses, Habilitations, scientific manuscripts and

research grants, and are active on editorial and advisory boards and on the boards of

national and international research societies.

Apart from these positive developments there was also sad news: In 2012 we lost two

colleagues, Stefan Wagner and Peter Wyskovsky, who were long-lasting members of the

IPA.

6

We are very sad that we have lost our colleagues and friends too early and will always

remember Peter and Stefan!

Stefan Wagner started as diploma student at the IPA and achieved the

venia docendi in 2008. Since then, he led the research group

„Experimental Immunobiology“ and focussed on the development of novel

therapies based on monoclonal antibodies. He has not only contributed to

scientific and teaching achievements of the IPA but has also successfully

established and implemented the quality management system. Besides,

Stefan was a talented cellist and has enriched many events of the IPA

and of the Medical University of Vienna with his musical performances.

Peter Wyskovsky started to work at the institute in 1972 and continued

his work until his retirement. He contributed to many studies

investigating physiological and pathological processes in the liver and

worked with Vitamin D. He was an expert in the perfusion of rat livers

to study metabolic processes in this organ. Peter Wyskovsky has

trained many students who afterwards succeeded in research or as

medical doctors in hospitals. He was an open-hearted personality and

a very gifted and patient teacher. Peter was a photographer and has

captured many highlights of the IPA.

Performance Report 2012 Organigram

7

Organigram (December 2012) Head: Barbara Bohle, PhD, Professor for Cellular Allergology Deputy Head: Peter Pietschmann, MD, Assoc. Professor Department Secretary: Marion Sack Check point: Andreas Kunrath Student Secretary: Marion Krones, Julia Krüger

Division for Comparative Immunology and Oncology Head: Erika Jensen-Jarolim, MD, Professor for Pathophysiology, Professor for Comparative Medicine Secretary: Nora Diallo, substituted by Katica Josipovic Erika Bajna, CTA, 50%

WG AllergoOncology: Head: Erika Jensen-Jarolim, MD, Professor Beatrix Pfanzagl, Ass. Professor Kumiko Oida, PhD-Student Krisztina Szalai, PhD Judit Fazekas, Diploma Student Franziska Roth-Walter, PhD Janis Kinkel, Diploma Student Anna Lukschal, PhD-Student Anna Moskovskich, Diploma Student Caroline Stremnitzer, PhD-Student Gesa Bindke, Diploma Student Josef Singer, PhD-Student Ferdinand Felix, Diploma Student Durga Krishnamurthy, PhD-Student Anna Willensdorfer, CTA Cristina Gomez-Casado, PhD-Student Miroslawa Matz, Tech. Ass

WG Tumor Pathology: Head: Enikö Kallay, PhD, Assoc. Professor Charlotte Gröschel, MD Samawansha Tennakoon, PhD-Student Julia Höbaus, PhD-Student Abhishek Aggarwal, PhD-Student Doris Hummel, PhD-Student Lukas Gober, Diploma Student Ursula Thiem, PhD-Student Teresa Manhardt, CTA Irfete Fetahu, PhD-Student Maria Elena Manfredini, Project manager

WG Gastrointestinal Immunology: Head: Eva Untersmayr-Elsenhuber, MD, Priv.-Doz. Susanne Diesner, MD Cornelia Schultz, BMA Vera Elisabeth Assmann, Diploma Student

WG Nutritional Immunology: Head: Isabella Pali-Schöll, PhD, Priv.-Doz.

WG Molecular System Biology and Pathophysiology Head: Diana Mechtcheriakova, PhD, Priv.-Doz. Martin Svoboda, PhD Susi Wöhrer, Diploma Student Anastasia Meshcheryakova, PhD-Student Elfi Scharf, Diploma Student Tamara Kaufmann, Diploma Student

Division for Cellular and Molecular Pathophysiology Head: Peter Pietschmann, MD, Assoc. Professor Secretary: Birgit Schwarz Erika Bajna, CTA, 50%

WG Bone, Cartilage and conn. Tissue Research: Head: Peter Pietschmann, MD, Assoc. Professor Andrea Kapfenberger, Diploma Student Ursula Föger-Samwald, MSci Zahra Umar, Diploma Student


8

Ursula Semrad-Azizi, PhD- Student Katharina Wahl, CTA Eduardo Maldonado-Gonzalez, PhD-Student WG Cell Biology: Head: Renate Fuchs, PhD, Assoc. Professor Leszek Gajdzik, Technician Julian Otto, Diploma Student Manuel Jalali, Diploma Student

WG Pathophysioloy of the Placenta: Head: Isabella Ellinger, PhD, Assoc, Professor Pia Habringer, Diploma Student Hana Uher, BMA Marin Schaffhauser, Diploma Student

WG Cellular Pathology and Pharmacokinetics: Head: Theresia Thalhammer, PhD, Assoc. Professor Erdentetsetseg Rentsen, PhD-Student Aida Larijani, Diploma Student Radu Rogojanu, PhD-Student Johann Grünsteidel, Diploma Student Madonna Awad, Diploma Student Leonard Ndue, Diploma Student Afarin Alaghebandan, Diploma Student Sultan Sirag, Diploma Student Lukas Klameth, Diploma Student Simone Zotter, Diploma Student

Division for Immunopathology Head: Rudolf Valenta, MD, Professor for Allergology Secretary: Doris Werjant Editorial Secretary: Sanna Lippert SFB-Secretary: Anna Guentcheva substituted by Julia Krüger Milena Weber, CTA

WG Molecular Immunopathology: Head: Rudolf Valenta, MD, Professor Birgit Linhart, PhD Eva Wollmann, PhD-Student Christian Lupinek, MD Bharani Srinivasan, PhD-Student Raffaela Campana, PhD Isabella Breyer, Diploma Student Katarzyna Niespodziana, PhD Mareike Appel, Diploma Student Mirela Curin, PhD, Marina Schuschnig, Diploma Student Julia Eckl-Dorna, MD, PhD Sandra Gutfreund, Diploma Student Kuan Wei-Chen, PhD Hannes Mayerhofer, Diploma Student Tetiana Garmatiuk, MD Renata Kiss, CTA Daniela Gallerano, PhD-Student Clarissa Cabauattan, PhD-Student

WG Immunotechnology: Head: Susanne Vrtala, PhD, Assoc. Professor Irene Mittermann, PhD Srinita Banerjee, PhD-Student Alexandra Baar, PhD-Student Yvonne Resch, PhD-Student Sandra Pahr, PhD-Student

WG Immunochemistry: Head: Margarete Focke-Tejkl, PhD, Univ.-Doz. Katharina Marth, MD Verena Hameter, Diploma Student

WG Antibody Research Head: Sabine Flicker, PhD, Priv.-Doz. Elisabeth Gadermaier, PhD Nazanin Najafi, PhD-Student Christoph Madritsch, PhD-Student


9

Division for Medical Biotechnology Head: Heimo Breiteneder, PhD, Professor for Medical Biotechnology Secretary: Carina Baderer Nina Lengger, BMA

WG Biotechnology & Biochemical Diagnostics: Head: Heimo Breiteneder, PhD, Professor Merima Bublin, PhD Daniele Pucciarelli, PhD-Student Christine Hafner, MD Daniele Ackerbauer, Diploma Student Barbara Gepp, PhD-Student

WG Molecular Allergology: Head: Karin Hoffmann-Sommergruber, PhD, Assoc. Professor Christiane Agreiter, Diploma Student Magdolna Vermes, ARat Maria Berneder, Diploma Student Gerlinde Hofstetter, BMA

WG Experimental Immunobiology: Head: Stefan Wagner, PhD, Assoc. Professor Kazem Ashjaei, PhD-Student

WG Biochemistry and Bioinformatics: Head: Christian Radauer, PhD, Priv.-Doz. Eva Gushl, PhD-Student

WG Molecular Research in Traditional Chinese Medicine: Head: Yan Ma, PhD, Priv.-Doz. Administration TCM: Linda Lam Karoline Peter, PhD-Student

Division for Experimental Allergology Head: Barbara Bohle, PhD, Professor for Cellular Allergology Secretary: Dorothea Angelides CD-Laboratory Secretary: Bana Haddad Birgit Nagl, BMA

WG Allergy Research: Head: Barbara Bohle, PhD Claudia Kitzmüller, PhD Dagmar Kollmann, PhD-Student Stephan Deifl, PhD-Student Christian Zwicker, Diploma Student Nora Zulehner, PhD-Student Julia Kalser, Diploma Student Brinda Subbarayal, PhD-Student Sandra Heizer, BMA

WG Cellular Allergology: Head: Beatrice Jahn-Schmid, PhD, Priv.-Doz. Dries van Hemelen, PhD-Student

Facility Services and Animal Keeping:

Katharina Reinberger Brigitte Schwarz Andrea Vlasaty


Personnel

10

a) Personnel of IPA (between January and December 2012)1

Personnel (p.) 01.01.2012 31.12.2012

MUW total female total female

Univ.Prof. (full professors) RV, EJJ, BB, HB 4.00 2.00 4.00 2.00 Ao.Univ.Prof (Assoc.Prof) IE, RF, PP, TT 4.00 3.00 4.00 3.00

Univ./Priv.Doz. (Assoc.Prof) EUE, BJS 2.00 2.00 2.00 2.00

Assistant professors BP,KHS,EK,SV,

SW 5.00 4.00 5.00 4.00

Univ.Assistants BL, CR, YM 3.00 2.00 3.00 2.00 Technical personnel NB,LG,TM,MM,

MV,AK,BN,MW,

EB

9.00 8.00 NL,LG,TM,MM,MV,KW,BN,MW,

EB

9.00 8.00

Administrative personnel CB,MS,KJ,MK½,

JK½,AK, DW,DA,BS½

7.50 6.50 7.50 6.50

Supportive personnel AV, KR, BS 3.00 3.00 3.00 3.00

37.50 30.50 37.50 30.50

Third party funded p. Scientific personnel Univ.Doz.

(Assoc.Prof)

MFT, SF, DM, IPS,MB

5.00 5.00 5.00 5.00

PostDoc 17.00 14.00 19.00 17.00 Doctoral students

2 34.00 26.00 33.00 27.00

Technical personnel BMA 5.00 5.00 4.00 4.00 CTA 2.00 2.00 3.00 3.00 Administrative personnel AG, BH, SL 3.00 3.00 BH, SL, JK 3.00 3.00 Project employees MS, MEM, UFS 1,25 1,25 MEM, UFS , LL 1.25 1.25 Diploma students (FB

3) 10.00 7.00 9.00 7.00

77.25 63.25 72.25 62.25

Other scientific coworkers

Doctoral students 6.00 4.00 4.00 2.00

Diploma students 15.00 6.00 17.00 7.00

Student apprentices

2.00 1.00 2.00 1.00

23.00 11.00 23.00 10.00

MUW personnel total 137.75 104.75 132.75 102.75

At the end of 2012 28,25% of the entire personnel was MUV-paid personnel. Of all IPA-employees 77,40% were female.

1 in full time equivalents “FTE” 40 h = 1 FTE 2 due to novel rules by FWF PhD students are employed 75 % FTE to be able to spend time for education 3 FB: Forschungsbeihilfe: defined financial support

Performance Report 2012 Impulsseminare

11

Continuous education of staff

Among the activities in the field of continuous education of the members of the

Department in 2012 five “impulse seminars” were held. In these seminars, research

group leaders present and discuss recent results from their projects. The seminars

were very well attended and significantly promoted communication and active

discussion among the members of the IPA. The “impulse seminars” are recognized

as continuous medical education by the Austrian Chamber of Physicians. In 2012 the

following topics were covered:

01.05.2012 Barbara Bohle An apple a day keeps the doctor away: News about birch pollen-related apple allergy

01.06.2012 Heimo Breiteneder IgE epitope mapping with single-chain antibodies

05.10.2012 Enikö Kallay Epigenetic Regulations and the Vitamin D System

09.11.2012 Isabella Ellinger Placental research in transition: From methodical to functional studies. A Janus view on recent past and near future

07.12.2012 Margit Focke-Tejkl Development of a new grass pollen allergy vaccine


Comparative Immunology and Oncology

12

1. Detailed Reports of Divisions

1.1 Division for Comparative Immunology and Oncology Head: Erika Jensen-Jarolim, MD, Professor

1. Publications4 IF pro-rata Number Top/Std/Subst

Erika Jensen-Jarolim 24.806 11 4/4/3

Isabella Pali-Schöll 2.314 5 1/2/2

Eva Untersmayr-E. 5.991 5 2/1/2

Enikö Kallay 6.106 3 0/2/1

Diana Mechtcheriakova 4.280 2 0/2/0

Division Sum 43.497

Top point score 2 - among top 20 % of journal in field

Standard point score 1 - between 21-60 %, Substandard point score 0,2

2. Supervision of diploma and doctoral students

Bachelor st. Diploma st. Doctoral st.

Erika Jensen-Jarolim - 6 7

Isabella Pali-Schöll 1 - 1

Eva Untersmayr-E. - 1 -

Enikö Kallay 1 7

Diana Mechtcheriakova 1 3 1

Sum 2 11 16

3. Teaching SS* WS* total W+S oral Exams

AG Erika Jensen-Jarolim 9.61 11.11 20.72 11 AG Isabella Pali-Schöll 0.20 1.21 1.41 - AG Eva Untersmayr-E. 1.00 3.90 4.90 -

AG Enikö Kallay 1.91 8.77 10.68

AG Diana Mechtcheriakova 1.76 3.05 4.81 -

Sum 14.48 28.04 42.52 11

4 For working groups IFs of all publications including joint publications with other working groups are presented. In contrast, the

given sum of the division represents the net value of IFs without overlaps due to joint publications.



13

1.1.1. Publications a) Peer-reviewed original articles: n = 12 Nr. Article IF Class pro-rata IF

1. Szalai, K., T. Kopp, A. Lukschal, C. Stremnitzer, J. Wallmann, P. Starkl, L. Vander Elst, JM. Saint-Remy, I. Pali-Schöll, E. Jensen-Jarolim*. Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice. Exp Dermatol. 2012 Nov, 21(11):842-6. doi: 10.1111/exd.12015.

3.543 St 3.543

2. Starkl, P., F. Felix, D. Krishnamurthy, SR. Prickett, AL. Voskamp, C. Stremnitzer, M. Weichselbaumer, F. Roth-Walter, RE. O’Hehir, E. Jensen-Jarolim*. An unfolded variant of the major peanut allergen Ara h 2 with hypoallergenic potential. Clin. Exp Allergy, 2012 Dec. 42(12):1801-12. doi: 10.1111/cea.12031.

5.032 Top 5.032

3. Diesner, SC., A. Olivera, S. Dillahunt, C. Schultz, T. Watzlawek, E. Förster-Waldl, A. Pollak, E. Jensen-Jarolim, E. Untersmayr, J. Rivera*. Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy. Immunol Lett. 2012 Jan 30;141(2):210-9. Epub 2011 Oct 14.

2.526 St 2.526

4. Amir, S., K. Hartvigsen, A. Gonen, G. Leibundgut, X. Que, E. Jensen-Jarolim, O. Wagner, S. Tsimikas, JL. Witztum, CJ. Binder. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease. J Lipid Res. 2012 Jul;53(7):1316-26. Epub 2012 Apr 16.

5.559 Top 1.112

5. Krishnamurthy, D., P. Starkl, K. Szalai, F. Roth-Walter, C. Mannhalter, E. Untersmayr, E. Jensen-Jarolim, 2012. Neutrophils and platelets participate in casein-induced anaphylaxis in an experimental BALB/c mouse model. Clin Exp. Allergy, 42:1119-28, DOI: 10.1111/j.1365-2222.2012.04012.x

5.032 Top 5.032

6. Singer, J., T. Stockner, M. Weichselbaumer, M. Willmann, Y. Sobanov, F. Wrba, R. Horvath, JG. Thalhammer, D. Mechtcheriakova, E. Jensen-Jarolim, 2012. Comparative oncology: ErbB-1 and ErbB-2 homologues in cancer of dog are susceptible to cetuximab and trastuzumab targeting. Mol Immun 2012; 0(4): 200-9. DOI:10.1016/j.molimm.2012.01.002.

2.897 St 2.897

7. Spillner, E., M. Plum, S. Blank, M. Miehe, J. Singer, I. Braren. Recombinant IgE antibody engineering to target EGFR. Cancer Immunol. Immunother; 2012 Sep. 61(9):1565-73. doi: 10.1007/s00262-012-1287-4

3.701 St 0.740

8. Jensen-Jarolim, E., G. Pawelec. The nascent field of AllergoOncology. Cancer Immunol Immunother. 2012 Sep;61(9):1355-7. Epub 2012 Aug 22.

3.701 St 3.701

9. Dicke, T., - , A. Kaufmann, St. Bauer, H. 2.790 St 0.558

http://www.ncbi.nlm.nih.gov/pubmed/23163649





14

Renz, H. Garn, Absence of unspecific innate immune cell activation by GATA-3- specific DNAzymes. Nucleic Acid Therapeutics, 2012; 22(2):117-126.

10. Höbaus, J., IS. Fetahu, M. Khorchide, T. Manhardt, E. Kallay . Epigenetic regulation of the 1,25-dihydroxyvitamin D(3) 24-hydroxylase (CYP24A1) in colon cancer cells. J Steroid Biochem Mol Biol. 2012 Aug 20 pii: S0960-0760(12)00146-X

3.053 St. 3.053

11. Hummel, DM., U. Thiem , J. Höbaus , I. Mesteri , L. Gober , C. Stremnitzer , J. Graça , B. Obermayer-Pietsch , E. Kallay . Prevention of preneoplastic lesions by dietary vitamin D in a mouse model of colorectal carcinogenesis. J Steroid Biochem Mol Biol. 2012 Aug 20 pii: S0960-0760(12)00146-X

3.053 St. 3.053

12. Brozek, W., T. Manhardt., E. Kállay., M. Peterlik, H.S. Cross. Relative expression of vitamin D hydroxylases, CYP27B1 and CYP24A1, and of cyclooxygenase-2 and heterogeneity of human colorectal cancer in relation to age, gender, tumor location, and malignancy: Results from factor and cluster analysis. 2012. Cancers 4 (3) , pp. 763-776.

n.d. --- ---

sum 40.887 31.247 b) Invited Articles & Reviews with IF: n = 5 Nr. Article IF Class pro-rata IF

1. Bousquet, J., I. Pali-Schöll, et al. ARIA (Allergic Rhinitis and its Impact on Asthma) - Achievements in 10 years and future needs. J Allergy Clin Immunol, 2012; 130(5):1049-1062

11.000 Top 2.200

2. Diesner, SC., E. Förster-Waldl, A. Olivera, A. Pollak, E. Jensen-Jarolim, E. Untersmayr. Perspectives on immunomodulation early in life. Pediatric Allergy and Immunology, 2012 May, 23(3):210-23. doi: 10.1111/j.1399-3038.2011.01259.x.

2.459 Top 2.459

3. Diesner, SC., X. Wang, E. Jensen-Jarolim, E. Untersmayr, F. Gabor. Use of lectin-functionalised particles for oral immunotherapy, 2012 Feb. Therapeutic Delivers, 3(2):277-90.

n.d. --- ---

4. Diesner, SC., I. Pali-Schöll, E. Jensen-Jarolim, E. Untersmayr. Mechanismen und Risikofaktoren für Typ 1 Nahrungsmittelallergien: Die Rolle der gastrischen Verdauung. WMW, December 2012, Volume 162, Issue 23-24, pp 513-518. IF 0

n.d. --- ---

5. Mechtcheriakova, D., M. Swoboda, A. Meshcheryakova, E. Jensen-Jarolim. Activation-induced cytidine deaminase (AID) linking Th2 responses and cancer.Cancer Immunol.Immunother. 2012 Sep. 61(9):1591-8. doi: 10.1007/s00262-012-1255-z.

3.701 St. 3.701

sum 17.16 8.36

http://www.ncbi.nlm.nih.gov/pubmed?term=Hummel%20DM%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Thiem%20U%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=H%C3%B6baus%20J%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Mesteri%20I%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Gober%20L%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Stremnitzer%20C%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Gra%C3%A7a%20J%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Obermayer-Pietsch%20B%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Obermayer-Pietsch%20B%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Kallay%20E%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://link.springer.com/journal/10354/162/23/page/1

http://link.springer.com/journal/10354/162/23/page/1



15

c) Invited Articles & Reviews without IF: n = 0 d) Book contributions: n =1 1. Untersmayr, E., G. Bises, P. Starkl, C. Schultz, CL. Bevins, G. Boltz-Nitulescu, O.

Scheiner, F. Wrba, E. Jensen-Jarolim. FcεRI subunit expression pattern: functional implication in IgE-mediated intestinal disorders. In: G. Marone, J. Ring, (Eds.), Translational Science: From Basic to Clinical Immunology and Allergy (Proceedings of the 28th Symposium of the Collegium Internationale Allergologicum, 2012.

e) Abstracts, printed in periodicals: n = 15 1. Höbaus, J., IS. Fetahu, A. Aggarwal, DM. Hummel, I. Mesteri, E. Kállay.

Overexpression of the vitamin D degrading enzyme CYP24A1 in highly proliferative tumours. Oral presentation at the International Conference on Progress in Bone and Mineral Research 2012 Vienna 2012, Bone 2012 Vol 51. No 6.

2. Höbaus, J., U. Thiem, D. Hummel, I. Fetahu, L. Gober, T. Manhardt, E. Kallay.

Possible causes and consequences of the overexpression of the vitamin D catabolizing enzyme CYP24A1 in colorectal cancer. Journal of Clinical Endocrinology and Metabolism 5, 6. Oral presentation at the 17. Jahrestagung der Österreichischen Gesellschaft für Endokrinologie und Stoffwechsel ( April 19–20, Graz)

3. Hummel, DM., U. Thiem, J. Höbaus, IS. Fetahu, T. Manhardt, I. Mesteri, E. Kallay.

High Dietary Vitamin D Reduces the Load of Chemically-Induced Colorectal Tumors in Mice. Journal of Clinical Endocrinology and Metabolism 5, 6. Oral presentation at the 17. Jahrestagung der Österreichischen Gesellschaft für Endokrinologie und Stoffwechsel ( April 19–20, Graz, poster presentation)

4. Hummel, DM., U. Thiem , IS. Fetahu, J. Höbaus , L. Gober , N. Hacker , J. Graça , I.

Mesteri , E. Kallay . High dietary vitamin D can prevent chemically-induced colorectal tumorigenesis in mice. International Conference on Progress in Bone and Mineral Research 2012 Vienna 2012, Bone 2012 Vol 51. No 6.

5. Aggarwal, A., J. Höbaus, IS. Fetahu, I. Mesteri, E. Kállay. Involvement of the Calcium

Sensing Receptor in colorectal cancer proliferation. Oral presentation at the International Conference on Progress in Bone and Mineral Research 2012 including a symposium on Calcium Sensing Receptor, Vienna 2012, Bone 2012 Vol 51. No 6.

6. Tennakoon, S., B. Marian, J. Schmid, K. Kallay; Regulation of signalling pathways by

extracellular calcium and colon cancer cells. Oral presentation at the International Conference on Progress in Bone and Mineral Research 2012 including a symposium on Calcium Sensing Receptor, Vienna 2012, Bone 2012, No 6.

7. Gröschel, C., D. Hummel, T. Nittke, T. Manhardt, E. Kállay. The role of serine/threonine

protein kinases in regulating expression of the vitamin D metabolizing enzyme CYP24A1 in colon cancer. Poster presentation at the International Conference on Progress in Bone and Mineral Research 2012 including a symposium on Calcium Sensing Receptor, Vienna 2012, Bone 2012, Vol 51. No 6.

8. Fetahu, IS., J. Höbaus, D. Hummel, C. Gröschel, S. Tennakoon, T. Manhardt, I. Mesteri, S. Baumgartner-Parzer, E. Kallay. 2012. Involvement of epigenetic mechanisms in regulating expression of the calcium-sensing receptor in colorectal




http://www.ncbi.nlm.nih.gov/pubmed?term=Gober%20L%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Stremnitzer%20C%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Gra%C3%A7a%20J%5BAuthor%5D&cauthor=true&cauthor_uid=22982628

http://www.ncbi.nlm.nih.gov/pubmed?term=Mesteri%20I%5BAuthor%5D&cauthor=true&cauthor_uid=22982628




16

cancer. Bone 2012, Vol. 51, No 6. S23. Oral presentation at International Conference on Progress in Bone and Mineral Research 2012 including a symposium on Calcium Sensing Receptor, November 29-December 1, 2012. Vienna, Austria.

9. Fetahu, IS., J. Höbaus, D. Hummel, C. Gröschel, S. Tennakoon, T. Manhardt, I.

Mesteri, S. Baumgartner-Parzer, E. Kallay. 2012. Involvement of epigenetic mechanisms in regulating expression of the calcium-sensing receptor in colorectal cancer. Journal of Bone and Mineral Research 51, Issue.6, S23. Oral presentation at International Conference on Progress in Bone and Mineral Research 2012 including a symposium on Calcium Sensing Receptor, November 29-December 1, 2012. Vienna, Austria.

10. Fetahu, IS., J. Höbaus, D. Hummel, U. Thiem, T. Manhardt, E. Kallay. 2012. Are

epigenetic mechanisms responsible for silencing the calcium sensing receptor in colorectal cancer? European Journal of Cancer 48, Suppl. 5, S141. Poster presentation at the European Association for Cancer Research (EACR). July 2012. Barcelona, Spain.

11. Fetahu, IS., J. Höbaus, D. Hummel, U. Thiem, T. Manhardt, E. Kallay. 2012. Epigenetic

mechanisms and their role in regulation of the calcium sensing receptor expression in colorectal cancer. Journal of Clinical Endocrinology and Metabolism 5, 6. Oral presentation at the 17th Annual meeting of the Austrian Society for endocrinology and metabolism. April 2012. Graz, Austria.

12. Meshcheryakova, A., M. Svoboda, E. Bajna, et al. Title: Density and Organization of B

Cells, Including the Activation-induced Cytidine Deaminase (AID)-positive Sub-population, Within Active Tumor Border of Human Colorectal Cancer Liver Metastases Shows a Positive Association With Survival Prognosis. Conference: 22nd Biennial Congress of the European-Association-for-Cancer-Research Location: Barcelona, SPAIN Date: JUL 07-10, 2012 Source: EUROPEAN JOURNAL OF CANCER Volume: 48 Supplement: 5 Pages: S267-S267 Meeting Abstract: 1109 Published: JUL 2012

13. Meshcheryakova, A., M. Svoboda, E. Jensen-Jarolim; et al. Title: Understanding the

Potential Role of Sphingolipid Machinery Within the Epithelial to Mesenchymal Transition Process Using a Multigene-signature-based Expression Profiling Approach. Conference: 22nd Biennial Congress of the European-Association-for-Cancer-Research Location: Barcelona, SPAIN Date: JUL 07-10, 2012 Source: EUROPEAN JOURNAL OF CANCER Volume: 48 Supplement: 5 Pages: S106-S106 Meeting Abstract: 440 Published: JUL 2012

14. Svoboda, M., T. Kaufmann, A. Meshcheryakova.; et al. Title: Multigene Signature

Approach to Assess the Role of AID/APOBEC Family Members During the Epithelial-to-mesenchymal Transition Program Author(s): Conference: 22nd Biennial Congress of the European-Association-for-Cancer-Research Location: Barcelona, SPAIN Date: JUL 07-10, 2012 Source: EUROPEAN JOURNAL OF CANCER Volume: 48 Supplement: 5 Pages: S111-S111 Meeting Abstract: 464 Published: JUL 2012

15. Singer, J.; M. Weichselbaumer; T Stockner; et al. Title: Comparative oncology: ErbB-1 and ErbB-2 homologues in canine cancer are susceptible to cetuximab and trastuzumab targeting Author(s): Source: MOLECULAR IMMUNOLOGY Volume: 50 Issue: 4 Pages: 200-209 DOI: 10.1016/j.molimm.2012.01.002 Published: APR 2012



17

f) Abstracts, in congress proceedings or abstract books: n = 52 1. Singer, J., K. Szalai, K. Thell, M. Ritter, B. Pfanzagl, A. Willensdorfer, C. Stremnitzer,

U. Michaelis, E. Jensen-Jarolim, Evaluation of Immunogenicity and safety aspects of Adeno-associated virus-like particles (AAVLPs) as carriers for B-cell vaccines in an OVA-allergy model, 10th EAACI – European Academy of Allergy and Clinical Immunology, GA²LEN Immunology Winter School, Basic Immunology Research in Allergy, Are, Sweden, February 12-15, 2012

2. Diesner, SC., A. Olivera, S. Dillahunt, C. Schultz, T. Watzlawek, E. Förster-Waldl, A.

Pollak, E. Jensen-Jarolim, E. Untersmayr and J. Rivera, Sphingosine 1 phosphate homeostasis affects intestinal allergen uptake and oral sensitization in a mouse foodallergy model, 10th EAACI – European Academy of Allergy and Clinical Immunology, GA²LEN Immunology Winter School, Basic Immunology Research in Allergy, Are, Sweden, February 12-15, 2012

3. Jensen-Jarolim, E., K. Thell, K. Szalai, J. Singer, A. Willensdorfer, C. Stremnitzer, U.

Michaelis, M. Weghofer, Addressing immunogenicity and safety of B-Cell vaccines displayed by adeno-associates virus-like particles, 2nd Annual Global Vaccine Forum, Vienna, Austria, March 1-2, 2012

4. Singer, J., K. Szalai, K. Thell, A. Willensdorfer, C. Stremnitzer, H. Szöllösi, U.

Michaelis, M. Weghofer, E. Jensen-Jarolim, Evaluation of Adeno-associated virus likeparticles (AAVLP) coupled with HER-2 mimotopes as novel carrier system for anti-tumor vaccines, Annual Congress of the American Association for Cancer Research, Chicago, IL, March 31 – April 4, 2012

5. Syre, K., S. Wöhrl, G. Stingl, E. Jensen-Jarolim, T. Kinaciyan, Diagnosis and cross-

reactivity patterns in delayed type hypersensitivity reactions to parenteral anticoagulants, EAACI – European Academy of Allergy and Clinical Immunology Meeting, DHM5, Munich, April 11-14, 2012

6. Jensen-Jarolim, E., K. Szalai, K. Thell, A. Willensdorfer, J. Singer, M. Weghofer, U.

Michaelis, Safety Aspects of Allergen Subunit Vaccines , Adjuvant 2012 & Allergen Vaccines 2012 International Congress, Cuba, May 6-11, 2012

7. Jensen-Jarolim E, Singer J, Szalai K, Riemer AB, Mimotope vaccines against cancer to

induce IgG or IgE, Adjuvant 2012 & Allergen Vaccines 2012 International Congress, Cuba, May 6-11, 2012

8. Stremnitzer, C., K. Szalai, P. Starkl, A. Willensdorfer, S. Schrom, U. Reichart, M.

Mildner, E. Jensen-Jarolim, In skin, sensitization to the house dust mite allergen Der p 2 is not solely dependent upon TLR-4 activation, 8thPhD-Symposium, Young Scientist Association of the Medical University of Vienna, Vienna, AKH-Campus, June 13-14, 2012

9. Fazekas, J., J. Singer, M. Weichselbaumer, W. Wang, A. Mader, M. Matz, W.

Steinfellner, Y. Sobanov, D. Mechtcheriakova, E. Spillner, R. Kunert, E. Jensen-Jarolim, Expression of canine immunoglobulins against the tumour antigen EGFR, 8thPhD-Symposium, Young Scientist Association of the Medical University of Vienna, Vienna, AKH-Campus, June 13-14, 2012

10. Oida, K., A. Matsuda, A. Itai, E. Jensen-Jarolim, K. Ohmori, H. Matsuda, A. Tanaka,

NF- -independent growth of breast cancer cells,



18

EAACI – European Academy of Allergy and Clinical Immunology Congress, Geneva, June 16-20, 2012

11. Fazekas, J., J. Singer, W. Wang, M. Weichselbaumer, M. Mader, M. Matz, W.

Steinfellner, Y. Sobanov, D. Mechtcheriakova, W. Willmann, E. Spillner, R. Kunert, E. Jensen-Jarolim, Generation of a canine anti-ErbB-1 antibody for proof of concept studies of immunotherapy of cancer in veterinarian medicine, EAACI – European Academy of Allergy and Clinical Immunology Congress, Geneva, June 16-20, 2012

12. Stremnitzer, C., K. Szalai, A. Willensdorfer, P. Starkl, S. Schrom, U. Reichart, S.

Knapp, E. Jensen-Jarolim, Epicutaneous sensitization induces a Der p 2-specific, TH2-biased antibody response independent of TLR4 expression, European Congress of Immunology / Annual meeting of the Austrian Association of Allergy and Immunology, Glasgow, September 5-8, 2012

13. Lukschal, A., J. Wallmann, M. Bublin, D. Neumann, H. Breiteneder, B. Hantusch, T.

Stocker, I. Pali-Schöll, E. Jensen-Jarolim, A peptide mimicking an important epitope cross-reactive between birch pollen proteins and the celery allergen Api g 5, European Congress of Immunology / Annual meeting of the Austrian Association of Allergy and Immunology, Glasgow, September 5-8, 2012

14. Lukschal, A., J. Wallmann, A. Mari, C. Harwanegg, M. B. Mittlböck, Hantusch, K.

Szalai, I. Pali, E. Jensen-Jarolim, Prevalence of recognition of Phl p 5 B-cell epitope mimic H32 in patients from an Italian allergy clinic, European Congress of Immunology / Annual meeting of the Austrian Association of Allergy and Immunology, Glasgow, September 5-8, 2012

15. Schultz, C., SC. Diesner, F. Roth-Walter, T. Eiwegger, A. Pollak, Z. Szepfalusi, I. Pali-

Scholl, E. Jensen-Jarolim, F. Gabor, E. Untersmayr. M-cell specific targeting by neuraminidase-functionalized micro-particles as a novel oral immunotherapy for food allergy, European Congress of Immunology / Annual meeting of the Austrian Association of Allergy and Immunology, Glasgow, September 5-8, 2012

16. Roth-Walter, F., A. Willensdorfer, C. Stremnitzer, C. Schultz, S. Diesner, R. Zadnikar,

J. Fazekas, E. Untersmayr, I. Pali- Schöll, E. Jensen-Jarolim, Acrolein hampers antibody-formation upon nasal sensitization with KLH, European Congress of Immunology / Annual meeting of the Austrian Association of Allergy and Immunology, Glasgow, September 5-8, 2012

17. Schultz, C., S. Diesner, XY. Wang, V. Assmann, K. Kreiner, G. Ratzinger, F. Roth-

Walter, P. Starkl, D. Krishnamurthy, T. Eiwegger, A. Pollak, Zs. Szépfalusi, I. Pali-Schöll, E. Jensen-Jarolim, F. Gabor, E. Untersmayr, M-cell specific targeting by neuraminidase-functionalized microparticles as a novel oral immunotherapy for food allergy, CEPII- Center for Pathophysiology, Infectiology and Immunology, Zentrumsretreat, September 18, 2012

18. Gómez-Casado, C., L. Tordesillas, J. Cuesta-Herranz, P. Gamboa, A. Palacín, A. Díaz-

Perales, Pru p 3 mutants exhibit low IgE- binding capacity: a good strategy for specific peach immunotherapy, EACR – The European Association for Cancer Research Meeting, Dublin, September 17-19, 2012

19. Meshcheryakova, A., M. Svoboda, E. Jensen-Jarolim, D. Mechtcheriakova,

Understanding the potential role of sphingolipid machinery within the epithelial to mesenchymal transition process using a multigene-signature-based expression



19

profiling approach, EACR – The European Association for Cancer Research Meeting, Dublin, September 17-19, 2012

20. Roth-Walter, F., A. Willensdorfer, C. Stremnitzer, C. Schultz, S. Diesner, R. Zadnikar,

J. Fazekas, E. Untersmayr, I. Pali-Schöll, E. Jensen-Jarolim, Acrolein hampers antibody-formation upon nasal sensitization with KLH, ÖGAI-Österreichische Gesellschaft für Allergologie und Immunologie, Symposium of the Austrian Association of Allergy and Immunology, Klosterneuburg, November 30, 2012

21. Szalai, K., C. Stremnitzer, P. Starkl, A. Willensdorfer, S. Schrom, M. Mildner, U.

Reichart, E. Jensen-Jarolim, Skin sensitization with the house dust mite allergen Der p 2 is not exclusively mediated by TLR4 activation, ÖGAI-Österreichische Gesellschaft für Allergologie und Immunologie, Symposium of the Austrian Association of Allergy and Immunology, Klosterneuburg, November 30, 2012

22. Fazekas, J., J. Singer, W. Wang, A. Mader, M. Matz, W. Steinfellner, Y. Sobanov, D.

Mechtcheriakova, M. Willmann, E. Spillner, R. Kunert, E. Jensen-Jarolim, A comparative oncology study: anti-tumor immunotherapy targeted against EGFR in canine mammary carcinoma, ÖGAI-Österreichische Gesellschaft für Allergologie und Immunologie, Symposium of the Austrian Association of Allergy and Immunology, Klosterneuburg, November 30, 2012

23. Lukschal, A., M. Bublin, J. Wallmann, D. Neumann, T. Stocker, H. Breiteneder, I. Pali-

Schöll, E. Jensen-Jarolim, A peptide mimicking an important epitope cross-reactive between birch pollen and celery allergen Api g 5, ÖGAI-Österreichische Gesellschaft für Allergologie und Immunologie, Symposium of the Austrian Association of Allergy and Immunology, Klosterneuburg, November 30, 2012

24. Höbaus, J., U. Thiem, A. Aggarwal, IS. Fetahu, DM. Hummel, E. Kállay. Expression of

the 24-hydroxylase CYP24A1 correlates with gene amplification in highly proliferative colorectal tumors. 15th Workshop on Vitamin D (June 20-22, Houston, TX, USA, poster presentation)

25. Hummel, DM., U. Thiem, IS. Fetahu, J. Höbaus , T. Manhardt, E. Kallay . Effects of

dietary vitamin D on ch emically-induced colorectal tumors in mice. 15th Workshop on Vitamin D (June 20-22, Houston, TX, USA, poster presentation)

26. Aggarwal, A., J. Höbaus, IS. Fetahu, I. Mesteri, E. Kállay. Role of the CaSR in

colorectal cancer proliferation. International Conference on Stem Cell and Cancer (October 27-30, New Delhi, India, Oral Presentation)

27. Aggarwal, A., J. Höbaus, IS Fetahu, I. Mesteri, E. Kállay. Role of the Calcium Sensing

Receptor in regulating colorectal cancer proliferation. Poster presentation at the 12nd Symposium of the European Calcium Society on Calcium Binding Proteins in Normal and Transformed Cells, September 2012, Toulouse, France.

28. Aggarwal, A., J. Höbaus, IS. Fetahu, I. Mesteri, E. Kállay. Calcium mediated growth

control in normal and transformed colon cells: A possible role of the Oral/Poster presentation at the Retreat of CEPII, Vienna, September 2012.

29. Aggarwal, A., J. Höbaus, IS. Fetahu, I. Mesteri, E. Kállay. Deciphering the role of the

Calcium Sensing Receptor in regulating colorectal cancer proliferation. Poster presentation at the 8th Annual meeting of the Young Scientist Association - PhD symposium. June 2012, Vienna, Austria.







20

30. Tennakoon, S., B.Marian, J. Schmid, E. Kallay. Impact of extracellular calcium on signalling pathways in colon cancer cells; Poster presentation at the 12nd Symposium of the European Calcium Society on Calcium Binding Proteins in Normal and Transformed Cells, September 2012, Toulouse, France.

31. Tennakoon, S., B. Marian, J. Schmid, E. Kallay. Influence on proliferative signalling

pathways by extracellular calcium in colon cancer cells. CEPII Oral/Poster presentation at the Retreat of CEPII, Vienna, September 2012.

32. Tennakoon S., B. Marian, J. Schmid, E. Kallay. Signalling pathways of the Calcium

Sensing Receptor in colonocytes. Poster presentation at the 8th Annual meeting of the Young Scientist Association - PhD symposium. June 2012, Vienna, Austria.

33. Gröschel, C., D. Hummel, T. Nittke, T. Manhardt, E. Kállay. The role of serine/threonine

protein kinases in regulating expression of the vitamin D metabolizing enzyme CYP24A1 in colon cancer Oral/Poster presentation at the Retreat of CEPII, Vienna, September 2012.

34. Fetahu, IS., J. Höbaus, C. Gröschel, S. Tennakoon, A. Aggarwal, T. Manhardt, I.

Mesteri, S. Baumgartner-Parzer, E. Kallay: Role of epigenetic mechanisms in regulating expression of the calcium-sensing receptor in colorectal cancer. Poster presentation at the 12nd Symposium of the European Calcium Society on Calcium Binding Proteins in Normal and Transformed Cells, September 2012, Toulouse, France.

35. Fetahu, IS., J. Höbaus, D. Hummel, U. Thiem, T. Manhardt, E. Kallay: Role of

epigenetic mechanisms in regulation of the calcium sensing receptor expression in colorectal cancer, Oral presentation at the 8th Annual meeting of the Young Scientist Association - PhD symposium. June 2012, Vienna, Austria.

36. Fetahu, IS., J. Höbaus, C. Gröschel, S. Tennakoon, A. Aggarwal, T. Manhardt, I.

Mesteri, S. Baumgartner-Parzer, E. Kallay: DNA methylation and histone acetylation: important players in regulating the calcium-sensing receptor expression in colorectal cancer. Oral/Poster presentation at the Retreat of CEPII, Vienna, September 2012.

37. Kallay, E., E. Hannan, N. Hübner, H. Schulz, RV. Thakker. Calcium-dependent

regulation of replication in colon cancer cells: a possible role for the calcium sensing receptor. Poster presentation at the 12nd Symposium of the European Calcium Society on Calcium Binding Proteins in Normal and Transformed Cells, September 2012, Toulouse, France.

38. Höbaus, J., IS. Fetahu, U. Thiem, E. Kallay. Altered CYP24A1 expression in colorectal

cancer: is DNA methylation the reason? 15th Workshop on Vitamin D (June 20-22, Houston, TX, USA, poster presentation)

39. Meshcheryakova, A., D. Tamandl, M. Svoboda, E. Bajna, J. Stift, M. Sachsenmaier, T.

Grünberger, E. Jensen-Jarolim, M. Bergmann, D. Mechtcheriakova. (DM invited talk) Degree and organization of immune cells including B-cell populations within the active border of human colorectal cancer liver metastases: novel prognostic marker for clinical outcome? November 2012, “Bench to Bedside” in Surgical Oncology, 36-th Symposium of Austrian Society of Surgical Research, Vienna, Austria

40. Svoboda, M., A. Meshcheryakova, T. Kaufmann, E. Bajna, E. Jensen-Jarolim, D.

Mechtcheriakova. EMT-MET plasticity: Does AID play a role? Annual Meeting OEGAI 2012, Vienna, Austria



21

41. Meshcheryakova, A., M. Svoboda, D. Heiden, E. Bajna, E. Jensen-Jarolim, D. Mechtcheriakova. A multigene signature-based approach to uncover the contribution of the sphingolipid machinery to the process of epithelial to mesenchymal transition. Annual Meeting OEGAI 2012, Vienna, Austria

42. Meshcheryakova, A., D. Tamandl, M. Svoboda, E. Bajna, J. Stift, D. Heiden, M.

Sachsenmaier, T. Grünberger, E. Jensen-Jarolim, M. Bergmann, D. Mechtcheriakova. Degree and organization of immune cells including B lymphocytes within the active border of human colorectal cancer liver metastases as prognostic marker for clinical outcome. Annual Meeting OEGAI 2012, Vienna, Austria

43. Meshcheryakova, A., M. Svoboda, E. Bajna, J. Stift, D. Heiden, E. Jensen-Jarolim, M.

Bergmann, D. Tamandl, D. Mechtcheriakova TissueFAXS-based algorithm for quantitative analysis of infiltrating immune cells within complex malignant tissues: novel strategy for patient risk stratification. Biomarker Development 2012, Concepts - Assays – Bioinformatics, Vienna, Austria

44. Meshcheryakova, A., M. Svoboda, E. Jensen-Jarolim, D. Mechtcheriakova

Sphingolipid-related multigene signature predicts novel mechanisms contributing to the process of epithelial to mesenchymal transition. Biomarker Development 2012, Concepts - Assays – Bioinformatics, Vienna, Austria


Mechtcheriakova. Multigene signature approach to delineate the role of AID-driven events under diseased conditions: A step towards Personalized Medicine. Biomarker Development 2012, Concepts - Assays – Bioinformatics, Vienna, Austria

46. Meshcheryakova, A., S. Svoboda, D. Heiden, E. Bajna, E. Jensen-Jarolim, D.

Mechtcheriakova. A multigene signature-based approach to uncover the contribution of sphingolipid machinery to the process of epithelial to mesenchymal transition. Retreat of the Center of Pathophysiology, Infectiology and Immunology, 2012 Vienna, Austria

47. Svoboda, M., A. Meshcheryakova, K. Tamara, T. Kaufmann, E. Bajna, E. Jensen-

Jarolim, D. Mechtcheriakova. Activation-induced cytidine deaminase (aid) at the crosstalk between immunity and cancer: multigene signature approach to assess role of aid in tumorigenicity and pluripotency of epithelial cells. Retreat of the Center of Pathophysiology, Infectiology and Immunology, 2012 Vienna, Austria

48. Meshcheryakova, A., D. Tamandl, M. Svoboda, E. Bajna, J. Stift, M. Sachsenmaier, T.

Grünberger, E. Jensen-Jarolim, M. Bergmann, D. Mechtcheriakova. TissueFAXS-based algorithm for quantitative analysis of infiltrating immune cell populations within complex malignant tissues: novel strategy for risk stratification of patients with colorectal cancer liver metastases. Tumor Microenvironment - Innovation in Cancer Therapy, 2012, Vienna, Austria

49. Meshcheryakova, A., S. Svoboda, D. Heiden, E. Bajna, E. Jensen-Jarolim, D.

Mechtcheriakova. Sphingolipid-related multigene signature predicts novel mechanisms contributing to the process of epithelial to mesenchymal transition. Tumor Microenvironment - Innovation in Cancer Therapy, 2012, Vienna, Austria


Mechtcheriakova. Multigene signature approach to assess the role of AID/APOBEC family members during the epithelial-to-mesenchymal transition program. EACR 2012, Barcelona, Spain



22

51. Meshcheryakova, A., M. Svoboda, E. Bajna, J. Stift, M. Sachsenmaier, T. Grünberger, E. Jensen-Jarolim, M. Bergmann, D. Tamandl, D. Mechtcheriakova. Density and organization of B cells, including the activation-induced cytidine deaminase (AID)-positive sub-population, within active tumor border of human colorectal cancer liver metastases shows a positive association with survival prognosis. EACR 2012, Barcelona, Spain

52. Meshcheryakova, A., M. Svoboda, E. Jensen-Jarolim, D. Mechtcheriakova.

Understanding the potential role of sphingolipid machinery within the epithelial to mesenchymal transition process using a multigene-signature-based expression profiling approach. EACR 2012, Barcelona, Spain

g) Teaching Scripts and Books: n = 0 h) Articles in Medical Journals: n = 1 Enikö Kallay 1. Der Calcium-sensing Rezeptor: J. Klin. Endokrinol. Stoffw. 2012. 5(4) 28-30. i) Public activity: n=8 Erika Jensen-Jarolim 1. Medienportal.univie.ac.at, „Startschuss für die Erforschung der Mensch-Tier-

Beziehung“, March 29, 2012

2. derstandard.at, „Kranksein ist für alle gleich“, April 3, 2012

3. de.sott.net, “Fastfood, Medikamente und übertriebene Hygiene als Ursache für Allergien“, October 8, 2012

4. Profil, “Heavy Metal”, November 19, 2012, profil 47, p 93-96

5. www.profil.at, “Krebs, Demenz, Allergie: Krank durch Aluminium”, November 21, 2012

6. www.meinbezirk.at, „Allergien auf Bestellung“, December 12, 2012 Enikö Kallay /Charlotte Gröschel 1. Nacht der Forschung 2012 „Science Dabei“ / Wissenschafterinnennetzwerk Medizin.

„Die Sonne, Deine Freundin und Helferin. Sonne, Vitamin D, Prävention, Krebs, chronische Erkrankungen“

Diana Mechtcheriakova online: 1. The Global Medical Discovery, a Canadian organization that publishes a selected list of

globally significant patents, discoveries and publications, has listed a recent article of Diana Mechtcheriakova and research team in collaboration with Erika Jensen-Jarolim entitled " Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer" published in Cancer Immunol Immunother as one of the

http://www.profil.at/

http://www.meinbezirk.at/



23

Key scientific articles. Link to the Global Medical Discovery: http://globalmedicaldiscovery.com/

j) Radio and TV interviews: n = 4 Erika Jensen-Jarolim 1. ORF 2, Konkret, Aluminium (Impact of aluminum on the induction of allergy),

November 21, 2012

2. ORF 2, MENSCHEN & MÄCHTE, Die Akte Aluminium (Film von Bert Ehgartner), November 21, 2012

Isabella Pali-Schöll 1. ORF 2, Konkret, Aluminium (Impact of aluminum on the induction of allergy),

November 21, 2012 2. ORF 2, MENSCHEN & MÄCHTE, Die Akte Aluminium, November 21, 2012 k) Lay Information: Brochures and Workshops: n = 2 Eva Untersmayr-Elsenhuber/Isabella Pali 1. REVAN (Richtig essen von Anfang an): Allergien vorbeugen in Schwangerschaft,

Stillzeit und Säuglingsalter Eva Untersmayr-Elsenhuber 1. Eva Untersmayr-Elsenhuber, Thomas Dorner. Allergien und Asthma. Wiener

Kindergesundheitssurvey 2012.

1.1.2. Research Awards: n = 31

1. Philipp Starkl: Max Kade Stipendium Titel: Interactions between mast cells and

complement anaphylatoxins, at Prof. Steve Galli Lab, Department of Pathology, Stanford University, 2012-13

2. Marlene Weichselbaumer: Dr. Maria Schaumayer Dissertations‐Preis für ihre

Dissertation "Evaluation of carcinoembryonic antigen and its receptor as potential immunotherapeutic targets in canine mammary cancer" 25. Jan. 2012

3. Marlene Weichselbaumer: Armin Tschermak von Seysenegg Award 4. Josef Singer: Travel grant for the AACR Annual Meeting 2012 (March 31- April 4,

2012, Chicago, Illinois 5. Judit Fazekas: RotePfote Science Communication Award 6. Caroline Stremnitzer: Travel Grant to European Congress of Immunology, Glasgow.

http://globalmedicaldiscovery.com/



24

7. Julia Höbaus: Felix Bronner Dissertationsstipendium 2012. Österreichische Gesellschaft für Knochen und Mineralstoffwechsel

8. Julia Höbaus: Young Investigator Award 2012. Fifteenth Vitamin D Workshop. 9. Julia Höbaus: Wissenschaftspreis 2012 Österreichische Gesellschaft für

Endokrinologie und Stoffwechsel 10. Julia Höbaus: Mentoring Award 2012 Österreichische Gesellschaft für Endokrinologie

und Stoffwechsel 11. Doris Hummel: Mentoring Award 2012 Österreichische Gesellschaft für

Endokrinologie und Stoffwechsel 12. Doris Hummel: Young Investigator Award 2012 Österreichische Gesellschaft für

Endokrinologie und Stoffwechsel 13. Doris Hummel: Böhringer Ingelheim Fonds Travel Grant for Research Stay in

Kuopio/Finland April-June 2012 14. Doris Hummel: Poster Prize at the 3rd Center Retreat 15. Doris Hummel: TransVir Winter school bursary 16. Doris Hummel: Travel Stipend for the 15th Workshop on Vitamin D in Houston/Texas 17. Abhishek Aggarwal: Rote Pfote Science Communication Award 2012 (Vienna,

Austria) 18. Abhishek Aggarwal: Best Abstract Prize -Travel Award 2012 at International

Conference on Stem Cell and Cancer (New Delhi, India)

19. Abhishek Aggarwal: Best Oral Presentation Award at the International Conference on Stem Cell and Cancer (New Delhi, India)

20. Abhishek Aggarwal: ECS Fellowship awarded by the European Calcium Society

(Toulouse, France). 21. Abhishek Aggarwal: TransVir Winter school bursary 22. Samawansha Tennakoon: TransVir Winter school bursary 23. Irfete Fetahu: Young Investigator Award 2012 – Austrian Society for Endocrinology

and Metabolism 24. Irfete Fetahu: Poster Prize at the 3rd Center Retreat 25. Irfete Fetahu: Travel Stipend for the 12th European Calcium Society

Meeting/Toulouse, France. 26. Irfete Fetahu: TransVir Winter school bursary 27. Anastasia Meshcheryakova was awarded at the 8th YSA-PhD-Symposium 2012



25

28. Anastasia Meshcheryakova: Award of the Center of Pathophysiology, Infectiology & Immunology.

29. Martin Svoboda: Award of the Center of Pathophysiology, Infectiology & Immunology

30. Cornelia Schultz: Travel grant of the Austrian Society of Allergology and Immunology

for the European Congress of Immunology, Glasgow, 5-8th September 2012 31. Susanne Diesner: Travel grant of the European Academy of Allergy and Clinical

Immunology (EAACI) for the EAACI Ga2len Winter School in Are, Sweden

1.1.3. Invited lectures: n = 15 Erika Jensen-Jarolim 1. Vergleichende Ansätze in der Krebstherapie bei Mensch und Tier. February 29, 2012,

The Austrian Chamber of Economy, Vienna.

2. Allergy vaccines: the task of immunizing hypersensitive patients. 2nd Annual Global Vaccine Forum, March 1-2, 2012, Vienna

3. Allergic to Food. Public Lecture at Medical University Vienna, March 10, 2012.

4. Von Chancen und Limitationen der Komparativen Medizin, Association for Human- Animal Relations. University of Veterinary Medicine Vienna, April 19, 2012.

5. Mimotope vaccines in cancer to induce IgG or IgE. Adjuvant & Allergen Vaccines 2012, Cuba, May 6 – 12, 2012.

6. Safety Aspects of Allergen Subunit Vaccines. Adjuvant & Allergen Vaccines 2012, Cuba, May 6 – 12, 2012.

7. One Medicine for Humans and Animals. Public lecture at University of Veterinary Medicine Vienna, June 2, 2012.

8. Eine Medizin für Mensch und Tier. Kindertierwoche, University of Veterinary Medicine Vienna, June 2, 2012

9. European Academy of Allergy and Clinical Immunology, Geneva, Switzerland, Symposium - Gender difference and immediate type hypersensitivity reactions, June 17, 2012

10. Comparative Medicine, a strategy to foster AllergoOncology. Dept. of Immunology, Capital Medical University Beijing, October 23, 2012

11. „Neue Biomarker aus der Komparativen Medizin“. der Österreichischen Gesellschaft für Labormedizin und klinische Chemie, Salzburg, November 9, 2012

12. Chip allergy diagnosis: Case Reports and their therapy options. MSD Symposium, Hotel Savoy, Vienna, Nov 21, 2012.

Krisztina Szalai 1. Skin sensitization with the house dust mite allergen Der p 2 is not exclusively



26

mediated by TLR4 activation Österreichisch Gesellschaft für Allergologie und Immunologie, IST, Klosterneuburg, 30. November 2012. Enikö Kallay 1. “Epigenetic regulation of the vitamin D System” 2012. September 6-7; Wroclaw

Seminar on Nuclear Receptors, Wroclaw, Poland

Diana Mechtcheriakova

1. Degree and organization of immune cells including B-cell populations within the active

border of human colorectal cancer liver metastases: novel prognostic marker for clinical outcome? November 2012, “Bench to Bedside” in Surgical Oncology, 36-th Symposium of Austrian Society of Surgical Research, Vienna, Austria

Eva Untersmayr-Elsenhuber 1. S1P as a potential novel biomarker of allergic reactions. 15° corso pratico finalizzato

allo sviluppo continuo professionale di allergologia clinica per medici e infermieri dam 15 - 2012, 28. November 2012, Mailand Italien.

1.1.4. Congress organization

Division member Name:

National congress

Name, date

Function Intern. congress, Name, date

Function

Erika Jensen-Jarolim Comparative Medicine Minisymposium “Refinement” with

RotePfote – Krebsforschung für das Tier. Vetmeduni Vienna,

03.07.2012

Host, Organiser

Erika Jensen-Jarolim Comparative Medicine Minisymposium

“Molecular Imaging” with RotePfote –

Krebsforschung für das Tier. Vetmeduni Vienna,

18.10.2012

Host, Organiser

Enikö Kallay Multifaceted CaSR Annual meeting 26-

28.11.2012

Host, Organiser

Enikö Kallay Calcium Sensing Receptor Symposium

30.11-1.12.2012.

Organiser

M.E. Manfredini, A. Aggarwal,

S. Tennakoon, I. Fetahu, J. Höbaus, D. Hummel, Ch. Gröschel

Calcium Sensing Receptor Symposium

30.11-1.12.2012.

Co-Organiser

Enikö Kallay International Conference on Progress in Bone and

Mineral Research 29-30.11.2012.

Co-Organiser



27

1.1.5. Hosting speakers

division member Speaker´s name Affiliation Date

Erika Jensen-Jarolim Dr. Giulia Gaydon Comparative Cognition, Messerli Research

Institute

January 12, 2012

Erika Jensen-Jarolim Prof. Hiroshi Matsuda Tokyo Agricultural University, Japan

March 19, 2012

Erika Jensen-Jarolim Prof. Claudia Stöllberger KH Rudolfsstiftung Vienna May 23, 2012

Erika Jensen-Jarolim Prof. Thomas Röder Zoologic Institute Christian-Albrechts-

University Kiel, Germany

July 3, 2012

Erika Jensen-Jarolim Dr. Peter König Institute of Anatomy University übeck,

Germany

July 3, 2012

Erika Jensen-Jarolim DDr. Luciana C. Mirotti Institute of Biomedical Sciences, University of

São Paulo, Brazil

July 3, 2012

Erika Jensen-Jarolim Dr. Sebastian Gehrig Clinical Department for Companion Animals and Horses, Clinical Unit of

Diagnostic Imaging

October 18, 2010

Erika Jensen-Jarolim Ao.Univ.-Prof. Dr. Sybille Kneissl

Clinical Department for Companion Animals and Horses, Clinical Unit of

Diagnostic Imaging

October 18, 2010

Erika Jensen-Jarolim Univ.-Prof. Thomas Helbich, MSc, MBA

Medical University of Vienna, Department for

Radiology

October 18, 2010

Diana Mechtcheriakova

Dr. Andreas Ritter von Onciul Ingenuity June 6, 2012

1.1.6. Mobility

Name Program University, Land Time frame Div In Out

Cristina Gomez-Casado

Span. Stip Universidad Politecnica de Madrid, Spain

07.08.2012-30.06.2013

1 x

Anna Moskovskich

MSc stud; Erasmus

Linköping University, Sweden 17.09.2012-30.09.2013

1 x

Judit Fazekas FWF University of Applied Sciences, FH Campus Wien

01.01.2012-14.03.2013

1 x

Philipp Starkl Max Kade Stipendium

Stanford University, California/USA 01.04.2012-open

1 x

Martin Svoboda FWF ETH/Nebion, Zürich, Switzerland 25.10.12-30.10.12

1 x

1.1.7. Activities in Advisory Boards

Name Society/Institute/Journal Function

Erika Jensen-Jarolim Medical University Vienna Member of Senate

Erika Jensen-Jarolim Research Center Borstel Member of Advisory Board

Erika Jensen-Jarolim Until May 2011: University Council of the Veterinary

University Vienna

Deputy Chair of Council

Erika Jensen-Jarolim Wiener Wirtschaftsförderungs- Kuratorium



28

und Technologiefonds (WWTF)

Erika Jensen-Jarolim Science jury of the county of Lower Austria

Juror

Erika Jensen-Jarolim Advisory Board für die Umsetzung der neuen Tierversuchsrichtlinie

Kommissionsmitglied

Erika Jensen-Jarolim Tierethik-Kommission der Gemeinde Wien

Mitglied der externen Gutachterkommission

Erika Jensen-Jarolim Niederösterr. Landesregierung (Erstellung der FTI-Strategie für

das Land NÖ)

Mitglied des Lenkungskreises

Erika Jensen-Jarolim Verein RotePfote President

Erika Jensen-Jarolim Österreichische Gesellschaft für Allergologie und Immunologie

Delegate zur World Allergy Organization

Erika Jensen-Jarolim Europäischen Akademie für Allergologie und Klinische

Immunologie (EAACI)

Mitglied der Interest Group for Comparative Veterinary

Allergology

Abhishek Aggarwal Samawansha Tennakoon

Julia Höbaus Irfete Fetahu

Doris Hummel

Young Scientist Association at the Medical University Vienna

Vice President Secretary Treasurer

Workshop Coordinator Communication Officer

1.1.8. Editorial Activities

Name Journal Function

Erika Jensen-Jarolim WAO Journal Associate Editor

Erika Jensen-Jarolim Wiener Med. Wochenschrift Associate Editor

Erika Jensen-Jarolim Int. Archs Allergy & Immunology Associate Editor

Erika Jensen-Jarolim Allergo Journal Associate Editor

Erika Jensen-Jarolim Immunology Letters Associate Editor

Erika Jensen-Jarolim The Open Allergy Journal Associate Editor

Erika Jensen-Jarolim Cancer Immunology, Immunotherapy

Associate Editor

1.1.9. Review Activities

Name Grants/Thesis/Habilitation

Erika Jensen-Jarolim PhD Thesis: Isabella Bejvl (Medical University Vienna)

Erika Jensen-Jarolim PhD Thesis: Martin Torzicky (Medical University Vienna)

Erika Jensen-Jarolim PhD Thesis: Anna Maria Eleonora Lukschal (Medical University Vienna)

Erika Jensen-Jarolim Diploma Thesis: Ferdinand Felix (Medical University Vienna)

Erika Jensen-Jarolim Diploma Thesis: Janis Kinkel (Medical University Vienna)

Erika Jensen-Jarolim MSc Diploma Thesis: Kathrin Thell (University Vienna)

Erika Jensen-Jarolim Habilitation: Dr. Eleonora Dehlink

Erika Jensen-Jarolim Habilitation: Dr. Thomas Eiwegger

Erika Jensen-Jarolim Habilitation: Dr. Andreas Brunner



29

Erika Jensen-Jarolim Habilitation: Dr. Jolanta Siller-Matula

Erika Jensen-Jarolim Habilitation: Dr. Andreas Janta

Erika Jensen-Jarolim Reviewer Wellcome Trust UK

Erika Jensen-Jarolim Academic Advisory Council Forschungszentrum Borstel

Erika Jensen-Jarolim Medical Research Council UK

Erika Jensen-Jarolim Jury: Science Award of Lower Austria

Erika Jensen-Jarolim Deutsche Gesellschaft für Kleintiermedizin

Erika Jensen-Jarolim Reviewer Research Grant Council of Hong Kong

Erika Jensen-Jarolim Steering Committee for building an FTI strategy (Lower Austria)

Erika Jensen-Jarolim WWTF: curatorium and committee Food & Nutrition

Erika Jensen-Jarolim Senate Medical University Vienna (appointments committee, senate committee for appeals in tuition- and

examination matters, senate committee for university courses)

Erika Jensen-Jarolim Reviewer: Journal of Allergy and Clinical Immunology

Erika Jensen-Jarolim Reviewer: PLoS One

Erika Jensen-Jarolim Reviewer: Cancer Immunology Immunotherapy

Erika Jensen-Jarolim Reviewer: Molecular Nutrition and Food Research

Erika Jensen-Jarolim Reviewer: Allergy Journal

Erika Jensen-Jarolim Reviewer: Clinical Experimental Allergy

Erika Jensen-Jarolim Reviewer: Cytokine

Erika Jensen-Jarolim Reviewer: Annals of Allergy, Asthma & Immunology

Erika Jensen-Jarolim Reviewer: World Journal of Pediatrics

Erika Jensen-Jarolim Reviewer: Journal of Pediatric Biochemistry

Enikö Kallay EU: Initial Training Network

Enikö Kallay FWO (Research Foundation Flanders) 2X

Enikö Kallay Cancer Research UK

Enikö Kallay Dutch Cancer society

Enikö Kallay EU: Marie Curie Individual Fellowships

Enikö Kallay PhD Thesis: Nair S. Lopes (Univ. Porto / Potugal)

Enikö Kallay PhD Thesis: Els Vanoirbeek (KU Leuven / Belgium)

Isabella Pali-Schöll Bentham Science Publisher: reviewer for the e-book proposal “Immunology of Pregnancy”

1.1.10. Filed and granted patents not disclosed

Name Patent

http://www.dict.cc/englisch-deutsch/academic.html

http://www.dict.cc/englisch-deutsch/advisory.html

http://www.dict.cc/englisch-deutsch/council.html



30

1.1.11. Grants Funding agency Title of project Principal investigator

FWF, doctoral college, CCHD

Cellular interactions decisive for immune response to oral antigens.

Erika Jensen-Jarolim

FWF Allergen mimotopes for epitope studies and vaccination. III.


Biomedical International R&D GmbH

Proof of Concept-Studien für Mimotop Impfstoffe I. Erika Jensen-Jarolim

FWF Targeting ERbB-1 and ERbB-2 overexpressed in cancer of dog by passive immunotherapy with lgG versus lgE antibodies. passive immunotherapy with lgG versus lgE antibodies.


FWF Development of mimotope vaccines for preclinical and comparative medicine studies. comparative medicine studies.


FWF Is cyp24a1 a proto-oncogene? A novel role for the catabolic vitamin D3 hydroxylase in colorectal tumourigenesis.

Enikö Kallay

Herzfelder’sche Familienstiftung

Is the calcium sensing receptor a tumour suppressor in colorectal cancer?

Enikö Kallay

Herzfelder’sche Familienstiftung

Modulating the Wnt-pathway in Premalignant Colorectal Adenoma in collaboration with B. Marian (Innere Med. I. Inst Cancer Research)

EU-Marie Curie The role of the Calcium Sensing Receptor (CaSR) in health and diseases, implications for translational medicine.

Enikö Kallay

FWF AID-gene regulatory network in cancer. Diana Mechtcheriakova

FWF Sphingolipid-related genes in cancer. Diana Mechtcheriakova

FFG, Bionanoinitiative Österreich

Nanohealth - NanoVac Isabella Pali-Schöll, Erika Jensen-Jarolim

FWF The impact of protein nitration on food allergy induction.

Eva Untersmayr-Elsenhuber

FWF Microparticles for oral immunotherapy of type I food allergy.


FWF-KLI Sphingosine-1-phosphate as a biomarker for disease severity of food adverse reaction.




31

1.1.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0 c) Professorships: n=0 d) Qualification Agreement: n = 2 1. Fulfillment of qualification criteria and appointment of Assoc. Prof. to Eva Untersmayr-

Elsenhuber (31.10.2012) 2. Enikö Kallay

1.1.13. Teaching a) Bachelor students: n =2 Isabella Pali-Schöll: Silke Schrom: 100% Bachelor thesis: Expression, Characterisation and Application of Recombinant Proteins for Studies of Allergic Diseases. 9 January 2012 - 9 May 2012. Bachelorstudiengang Molekulare Biotechnologie, Fachhochschule Campus Wien. Diana Mechtcheriakova Nadja Seidl: Assessment of the role of activation-induced cytidine deaminase, AID, during the epithelial-to-mesenchymal transition program” (2012-ongoing). University of Vienna b) Diploma, MDiploma and Master students: n =11 Erika Jensen-Jarolim: Kathrin Thell: MSc thesis: Proof of concept studies of tumor mimotope vaccines 2010 - 2012. Medical University Vienna Kinkel Janis: MDiploma thesis: Das Sensibilisierungspotenzial von durch Prozessierung veränderten Nahrungsmitteln. 2009-Ongoing. Medical University Vienna. Felix Ferdinand: MDiploma thesis: Der Einfluss von Prozessierung auf die Allergenität von Nahrungs-Proteinen. 2009-Ongoing, Medical University Vienna. Anna Moskovskich: MSc thesis: Immunoregulatory properties of Cinnamonaldehyde, 2012-Ongoing, Medical University Vienna Gesa Bindke: MSc thesis: Immunstimulatory properties of AAL upon oral delivery, 2012-Ongoing, Medical University Vienna



32

Judit Fazekas: MSc thesis: Expression of canine immunoglobulines against the tumor antigen EGFR. 2012 – 2013, Medical University Vienna Eva Untersmayr-Elsenhuber: Vera Elisabeth Assmann: MSc thesis: Factors influencing food allergy elicited by gastric acid suppression in a murine model, 2011 - Ongoing. University of Vienna Enikö Kallay Lukas Gober: Diploma thesis: Role of microRNAs in regulating the vitamin D signalling in colorectal cancer cells Diana Mechtcheriakova Tamara Kaufmann: Diploma thesis: Activation-induced cytidine deaminase (AID): potential novel biomarker and/or target during epithelial-to-mesenchymal transition program in cancer, 2011-Ongoing, University of Vienna Susi Wöhrer: Diploma thesis: The TissueFAXS-based algorithm to assess the prognostic significance of tumor-infiltrating immune cells in ovarian carcinoma, 2012-Ongoing, University of Vienna Elfi Scharf: Diploma thesis: The distribution pattern and prognostic power of tumor-infiltrating macrophages in ovarian carcinoma, 2012-Ongoing, University of Vienna c) PhD, MDSci, MD students: n = 16 Erika Jensen-Jarolim: Caroline Stremnitzer: PhD thesis: Molecular characteristics and biology of house dust mite allergens Der p1 and 2, 2010 – Ongoing, Medical University Vienna Singer Josef: PhD thesis: The role of IgE in cancer and allergy. 2010 – Ongoing, Medical University Vienna. Krishnamurthy Durga: PhD thesis: The role of the liver in the induction and control of food allergy, 2007 – Ongoing, Medical University Vienna. Lukschal Anna: PhD thesis: Epitop specific IgE detection, 2008 – Ongoing, Medical University Vienna. Cristina Gomez-Casado: PhD thesis: Molecular basis of allergenicity and cross-reactivity among plant food allergens, 2012 – Ongoing, Medical University Vienna Jordakieva Galateja: PhD thesis: Blutzellendynamik nach Allergener Exposition bei Sensibilisierten, 2012 – Ongoing, Medical University Vienna

Oida Kumiko: PhD thesis: Nuclear factor-B plays a critical role both in intrinsic and acquired resistance against endocrine therapy of human breast cancer cells, 2012 – Ongoing, Medical University Vienna



33

Isabella Pali-Schöll: Anna Lukschal: 5% PhD thesis: Epitop specific IgE detection, 2008-2012, Medical University Vienna. Enikö Kallay: Julia Höbaus: PhD thesis: Mechanisms of 25-Hydroxyvitamin D3-24-Hydroxylase Overexpression in Colorectal Cancer (in progress) Doris Hummel: PhD thesis: Is the vitamin D 25 hydroxylase an oncogene? (in Progress) Irfete Fetahu: PhD thesis: Regulators of the Calcium Sensing Receptor in colorectal cancer Samawansha Tennakoon: PhD Thesis: Ligand-dependent CaSR signalling in colonocytes Abishek Aggarwal: PhD thesis: Role of CaSR in proliferation of Colon Cancer Cells Charlotte Gröschel: Modulating the Wnt-Pathway in Colorectal Adenoma Cells, role of Vitamin D. Ursula Thiem: Co-Supervisor: Vitamin D and the immune system: Evaluation of the effects of high-dose vitamin D3 therapy in the immune response in vitamin D deficient kidney transplant recipients. Diana Mechtcheriakova Anastasia Meshcheryakova: PhD thesis. 2011 – Ongoing, Medical University Vienna

1.1.14. Exams a) Oral examinations: n = 3 Erika Jensen-Jarolim

Doctoral viva (functional Pathology)

Hinterleiter Claudia

Putz Markus Walter

Djordjevic Peter b) Bachelor, Diploma and Thesis-Examinations: n= 5 Erika Jensen-Jarolim PhD Thesis for: Frau Mag. Isabella Bejvl Dr. Martin Torizcky Mag. Anna Lukschal Enikö Kallay PhD Thesis for: Els Vanoirbeek KU Leuven / Belgium Nair S. Lopes Univ. Porto / Potugal c) Exam supervising: n = 0



34

1.1.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr.

SS 2012 Jensen-Jarolim Erika 2.00 0.67 648010 Progress Report in Comparative Allergology, Oncology and Immunology

Jensen-Jarolim Erika 2.00 0.33 860016 JC: New Developments and Comparative Aspects in Allergology, Oncology and Immunology

Jensen-Jarolim Erika 2.00 0.67 860057 TS: New Developments and comparative aspects in allergology, oncology and immunology

Jensen-Jarolim Erika 2.00 0.35 860079 JC New Developments and comparative aspects in allergology, oncology and immunology

Jensen-Jarolim Erika 2.00 0.07 860220 Basisvorlesung Immunologie

Jensen-Jarolim Erika 2.00 0.03 860961 CCHD Journal Club

Kallay Enikö 1.00 0.34 860005 Creative and critical Journal Club II

Kallay Enikö 2.00 0.67 860057 TS: New Developments and comparative aspects in allergology, oncology and immunology

Kallay Enikö 2.00 0.23 860800 Basic Seminar Malignant Diseases II

Kallay Enikö 2.00 0.67 648010 Progress Report in Comparative Allergology, Oncology and Immunology

Mechtcheriakova Diana 2.00 0.66 648010 Progress Report in Comparative Allergology, Oncology and Immunology

Mechtcheriakova Diana 2.00 0.33 860016 JC: New Developments and Comparative Aspects in Allergology, Oncology and Immunology

Mechtcheriakova Diana 2.00 0.66 860057 TS: New Developments and comparative aspects in allergology, oncology and immunology

Mechtcheriakova Diana 2.00 0.11 860961 CCHD Journal Club

Pali-Schöll Isabella 3.00 0.20 896009 Immunologie und Infektiologie aus genderspezifischer Sicht

Pfanzagl Beatrix 2.27 2.00 802001 BL 4 - Funktionssysteme und biologische Regulation

Pfanzagl Beatrix 2.27 5.28 802001 BL 4 - Funktionssysteme und biologische Regulation

Singer Josef 3.00 0.21 896009 Immunologie und Infektiologie aus genderspezifischer Sicht

Untersmayr-Elsenhuber Eva 1.00 1.00 800000 Senior-Mentoring Humanmedizin

Sum 14.48

WS 2012/13 Höbaus Julia 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Jensen-Jarolim Erika 5.80 0.40 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Jensen-Jarolim Erika 2.00 0.20 562019 BVo: Immunologie

Jensen-Jarolim Erika 3.00 0.20 648011 Immunpathologische Laboratoriumstechnik - mit Demonstrationen (Wahlfachausbildung gem. § 13/1 lit. a StG)

Jensen-Jarolim Erika 5.00 2.50 648012 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG)

Jensen-Jarolim Erika 2.00 0.67 648802 Progress Report in Comparative Allergology, Oncology and Immunology

Jensen-Jarolim Erika 2.00 0.33 860060 JC New Developments and comparative aspects in allergology, oncology and immunology

Jensen-Jarolim Erika 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology



35

Jensen-Jarolim Erika 6.00 0.28 860580 TS: CCHD Doctoral Seminar

Jensen-Jarolim Erika 2.00 0.30 860924 JC: CCHD

Kallay Enikö 5.80 0.27 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Kallay Enikö 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen

Kallay Enikö 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester

Kallay Enikö 1.00 0.33 860030 Creative and critical Journal Club III

Kallay Enikö 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology

Kallay Enikö 2.00 0.20 860966 Basisseminar: Zelluläre Signaltransduktion

Kallay Enikö 5.00 5.00 514051 Wachstumsregulation humaner Kolontumorzellen - (Wahlfachausbildung gem. § 13 StG)

Kallay Enikö 2.00 0.67 648802 Progress Report in Comparative Allergology, Oncology and Immunology

Mechtcheriakova Diana 3.00 1.40 648011 Immunpathologische Laboratoriumstechnik - mit Demonstrationen (Wahlfachausbildung gem. § 13/1 lit. a StG)

Mechtcheriakova Diana 2.00 0.66 648802 Progress Report in Comparative Allergology, Oncology and Immunology

Mechtcheriakova Diana 2.00 0.33 860060 JC New Developments and comparative aspects in allergology, oncology and immunology

Mechtcheriakova Diana 2.00 0.50 860061 TS: New Developments and comparative aspects in allergology, oncology and immunology

Mechtcheriakova Diana 6.00 0.05 860580 TS: CCHD Doctoral Seminar

Mechtcheriakova Diana 2.00 0.11 860924 JC: CCHD

Pfanzagl Beatrix 1.00 2.00 801011 Problemorientiertes Lernen - 1. Semester

Pfanzagl Beatrix 1.13 0.53 801001 BL 1 - Gesunde und kranke Menschen

Singer Josef 1.13 0.67 801001 BL 1 - Gesunde und kranke Menschen

Singer Josef 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Singer Josef 2.00 2.00 803009 Problemorientiertes Lernen - 3. Semester

Untersmayr-Elsenhuber Eva 3.00 1.40 648011

Immunpathologische Laboratoriumstechnik - mit Demonstrationen (Wahlfachausbildung gem. § 13/1 lit. a StG)

Untersmayr-Elsenhuber Eva 5.00 2.50 648012 Wissenschaftliche Arbeiten (Wahlfachausbildung für Dissertanten gem. § 13/1 lit. a StG)

Pali Isabella 3,00 0.11 805.000 BL 13 - Ernährung und Verdauung

Pali Isabella 2,00 0.50 860.061 TS: New Developments and comparative aspects in allergology, oncology and immunology

Pali Isabella 6,00 0.30 860.580 TS: CCHD Doctoral Seminar - WS

Pali Isabella 2,00 0.30 860.060 JC New Developments and comparative aspects in allergology, oncology and immunology

Sum 28.04

Total sum SS+WS 42.52

https://campus.meduniwien.ac.at/med.campus/lv.detail?cperson_nr=99806&clvnr=274995





Cellular and Molecular Pathophysiology

36

1.2. Division for Cellular and Molecular Pathophysiology Head: Peter Pietschmann, MD, Associate Professor 1. Publications5 IF Number Top/Std/Subst

Isabella Ellinger 0.199 -- 0/0/1

Renate Fuchs -- -- --

Peter Pietschmann 4.293 2.6 0/2/3

Theresia Thalhammer 2.329 1 0/1/0

Division-Sum 6.622 3,6





Isabella Ellinger 0 2 1

Renate Fuchs 0 3 0

Peter Pietschmann 1 9 3

Theresia Thalhammer 0 14 4

Sum 1 28 8


Isabella Ellinger 3.39 7.31 10.70 0 Renate Fuchs 3.63 11.83 15.46 0 Peter Pietschmann 6.56 22.07 28.63 6

Theresia Thalhammer 7.00 0.46 7.46 0

Sum 20.58 41.67 62.25 6





37

1.2.1. Publications a) Peer-reviewed original articles: n = 6 Nr. Article IF Class pro-rata IF

1. Schamall, D., P. Pietschmann, D. Moser, M. Dockner, and M. Teschler-Nicola. Diagnosis of contact injuries in a mediaeval skeleton analysed by µCT and histology. Wien Med Wochenschr 2012; 162:386-393.

-- SSt --

2. Kerschan-Schindl, K., J. Patsch, S. Kudlacek, A. Gleiss, and P. Pietschmann. Measuring quality of life with German osteoporosis quality of life questionnaire in women with osteoporosis. Wien Klin Wochenschr 2012; 124:532-537.

0.809 SSt 0.809

3. Kerschan-Schindl, K., P. Riss C. Krestan, M. Rauner, C. Bieglmayer, A. Gleiss, V. Fialka-Moser, B. Niederle, and P. Pietschmann. Bone metabolism in patients with primary hyperparathyroidism before and after surgery. Horm Metab Res 2012; 44:476-481.

2.188 St 2.188

4. Herman, S., D. Krenbek, M. Klimas, M. Bonelli, C.W. Steiner, P. Pietschmann, J.S. Smolen, and C. Scheinecker. Regulatory T cells form stable and long-lasting cell cluster with myeloid dendritic cells (DC). Int Immunol 2012; 24:417-426.

3.415 St 0.683

5. Heindl, A., K. Seewald, M. Schepelmann, R. Rogojanu, G. Bises, T. Thalhammer, and I. Ellinger. A novel nucleus-based classifier for discrimination of osteoclasts and mesenchymal precursor cells in mouse bone marrow cultures. ICMIA Proceedings 2012; NL 70000

0.199 -- 0.199

6. Kiskova, T., C. Ekmekcioglu, M. Garajová, P. Orendas, B. Bojková, N. Bobrov, W. Jäger, M. Kassayová, and T. Thalhammer. A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Eur J Cancer Prev 2012; 21:163-170.

2.130 St 2.130

sum 8.741 6.009

b) Invited Articles & Reviews with IF: n = 1 Nr. Article IF Class pro-rata IF

1. Gosch, M., C. Kammerlander, K. Pils, M. Lechleitner, U. Benvenuti-Falger, T. Roth, B. Joosten-Gstrein, and P. Pietschmann. Osteoporotic treatment options in geriatric patients. Z Gerontol Geriatr 2012; 45:417-428.

0.613 SSt 0.613

sum 0.613 0.613 c) Invited Articles & Reviews without IF: n = 6

1. Ellinger, I., and R. Fuchs. hFcRn-mediated transplacental immunoglobulin G transport: Protection of



38

and threat to the human fetus and newborn. Wien Med Wochenschr 2012; 162:207-213.

2. Ellinger, I. Editorial: The multifaceted human placenta – update on an amazing

organ. Wien Med Wochenschr 2012; 162:184-186. 3. Fuchs, R., and D. Blaas. Productive entry pathways of human rhinoviruses.

Advances in Virology 2012; doi:10.1155/2012/826301. 4. Pietschmann P. Editorial: Morbus Paget. J Miner Stoffwechs 2012; 19:2, p 61 5. Pietschmann, P. Editorial: =steology. Wien Med Wochenschr 2012; 162:369 6. Kurz, H. and P. Pietschmann. Infectious diseases in the past and today. Wien Med

Wochenschr 2012; 162:131. 7. Pietschmann, P. Musculoskeletal diseases. Wien Med Wochenschr 2012; 162:91. 8. Mikosch, P, and P. Pietschmann. Editorial: Nuclear and radiation accidents. Wien

Med Wochenschr 2012; 162:46. d) Book contributions: n = 9 1. Azizi-Semrad U, Pietschmann P, Willheim M. Effects of vitamin D in the immue

system. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 63-90

2. Bertl K, Pietschmann P, Matejka M. Osteoimmunological aspects of peridontal

diseases. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2011, pp. 241-267

3. Heindl A, Schepelmann M, Ecker R, Pietschmann P, Ellinger I, Seewald AK,

Thalhammer T. Towards the automated detection and characterization of osteoclasts in microscopic images. In: Pietschmann P (ed). Principles of Osteoimmunology – Molecular Mechanisms and Clinical Applications. SpringerWienNewYork 2012, pp. 27-48

4. Pietschmann P., K. Kerschan-Schindl, K. Redlich, M. Aringer. Osteoporose und

weitere metabolische Osteopathien. In: Stummvoll G, Pretterklieber ML, Kainberger F (eds). Bewegung und Leistung, Schmerz (MCW Block 21, 9. Auflage). Facultas Verlag 2012, pp. 127-139

5. Pietschmann P. Autoimmunendokrinologie. In: Ludvik B, Bischof M, Kraupp M,

Luger A (eds). Endokrinologie und Stoffwechsel (MCW Block 10). Facultas Verlag 2012, pp. 18-25

6. Pietschmann P, Nanoff C, Dudczak R, Kainberger F. Knochen- und Kalzium-

Stoffwechsel. In: Ludvik B, Bischof M, Kraupp M, Luger A (eds). Endokrinologie und Stoffwechsel (MCW Block 10). Facultas Verlag 2012, pp. 204-217

7. Patsch J, Pietschmann P. Degenerative und altersassoziierte Erkrankungen. In:

Marian B (ed). Krankheit, Krankheitsursachen und –bilder (MCW Block 8). Facultas Verlag 2012, pp.414-422



39

8. Erlacher L, Azizi-Semrad U, Pietschmann P. Bausteine des Bindegewebes. In: Dunky A, Graninger W, Herold M, Smolen J, Wanivenhaus A (eds.) Praktische Rheumatologie. Springer WienNewYork 2012, pp. 9-13

9. Pietschmann P, Kerschan-Schindl K. Osteoporose. In: Kautzky-Willer A (ed.).

Gendermedizin. Böhlau Verlag Wien-Köln-Weimar 2012, pp. 103-122

e) Abstracts, printed in periodicals: n = 4 1. Schraml S, Weilner S, Wassermann K, Wieser M, Messner P, Maier AB, Redl H,

Pietschmann P, Grillari-Voglauer R, Grillari J (2012) MicroRNA-31-a novel therapeutic target for bone regeneration and osteoporosis. Journal of Tissue Engineering and Regenerative Medicine 6:31-31

2. Föger-Samwald U, Patsch JM, Deutschmann J, Hornek L, Salem S, Becker P, Pail

P, Schamall D, Mousavi M, Becker S, Kainberger FM, Resch H, Pietschmann P (2012) Bone microarchitecture and local gene expression in elderly men with osteoporotic hip fractures. Bone 51:037, S13

3. Kocijan R, Muschitz C, Amrein K, Fahrleitner-Pammer A, Pietschmann P, Haschka

J, Dinu S, Resch H (2012) Serum sclerostin levels, bone turnover markers and body composition in mild, moderate and severe osteogenesis imperfecta. Bone 51:028, S10

4. Heindl A, Dekan S, Rogojanu R, Ecker R, Thalhammer T, Bises G, Uhrova H,

Seewald A, Ellinger I (2012). Methods for automated in situ analysis of biomarkers in human placental chorionic tissue- quantification of the receptor for advanced glycated end products (RAGE) in human healthy and pre-eclamptic placentas. Placenta 33 (9): A88

f) Abstracts, in congress proceedings or abstract books: n = 17 1. Rogojanu R, Bises G, Mesteri U, Thiem U, Heindl A, Seewald AK, Ellinger I,

Thalhammer T. An automated microscopic image analysing system for the determination of the epithelium to stroma ratio in colorectal cancer: Assessment of a putative marker for tumor progression. 4th International Conference on Drug Discovery & Therapy, Dubai, Vereinigte Arabische Emirate, 12.-15. 2 2012.(Poster)

2. Gajdzik L, Edlmayr J, Valenta R, Blaas D, Fuchs R. Entry of HRV89 involves

dynamin and clathrin. EUROPIC 2012, St. Raphael, Frankreich, 3.-8.6.2012. (Poster) 3. Molcan L, Ellinger I, Trubulová N, Zeman M. Expression of melatonin receptors in

mesenteric arteries of hypertensive rats. 10th Meeting of France - New EU Coutries, Hradec Králové, Tschechien, 12.-15.6.2012

4. Föger-Samwald U, Patsch J, Salem S, Pail P, Schamall D, Mousavi M, Kainberger

F, Pietschmann P (2012) Gene Expression and bone architecture in men with osteoporotic hip fractures. 8th YSA-PhD-Symposium, , Wien, 13. - 14.6.2012, Abstract book S 88, P62.

5. Kisková T, Jendzelovsky R. Papcova Z, Orendas P, Bojkova B, Kassayova M,

Fedorocko P (2012). Anti-tumour effects of combination resveratrol and celecoxib in vitro and in vivo. 8th YSA-PhD-Symposium, 13. - 14.6.2012 , Wien, Abstract book S 115, P116.



40

6. Heindl A, Dekan S, Rogojanu R, Ecker R, Bises G, Thalhammer T, Uhrova H,

Seewald AK, Ellinger I (2012). Expression level of the receptor for advanced glycated end products (RAGE) in the syncytiotrophoblast correlates with the severity of per-eclampsia as demonstrated by a novel method for automated in-situ quantifications of proteins. 8th YSA-PhD-Symposium, Wien, 13. - 14.6.2012, Abstract book S 102, P90.

7. Gonzalez-Sanchez E, Perez MJ, Nytofte NS, Briz O, Serrano MA, Monte MJ, Jimenez F, Gonzalez-San Martin F, Marin JJG. Protective effect of biliverdin and biliverdin reductase against bile acid-induced toxicity in liver cells. 8th YSA-PhD- Symposium, Wien, 13. - 14.6.2012, Abstract book S 95, P75 (Poster)

8. Rogojanu R, Thiem U, Mesteri I, Ellilnger I, Heindl A, Seewald AK, Haisan A,

Thalhammer T, Bises G. Automatic analysis of tumor budding in colorectal cancer specimens. 8th YSA-PhD-Symposium, Wien, 13. - 14.6.2012, Abstract book S 162, P 209 (Poster)

9. Misof B, Patsch J, Roschger P, Muschitz C, Paschalis E, Prokop E, Klaushofer K,

Pietschmann P (2012) Intravenous ibandronate treatment of 24 months increases cancellous and cortical bone mineralization density in male patients with idiopathic osteoporosis. ASBMR 2012 Annual Meeting, MO0069, S368

10. Heindl A, Seewald AK, Schepelmann M, Rogojanu R, Bises G, Thalhammer T,

Ellinger I. A novel nucleus-based classifier for discrimination of osteoclasts and mesenchymal precursor cells in mouse bone marrow cultures. WASET 2012 Amsterdam International Conference, Amsterdam, Niederlande, 25.-26.7.2012.(oral presentation)

11. Heindl A, Seewald A, Thalhammer T, Bises G, Dekan S, Mesteri I, Rogojanu R,

Ellinger I. Automated recognition of Tissue-associated erythrocytes (ARETE) – A new tool in Tissue-Cytometry. 54th Symposium of the Society for Histochemistry, Wien, 5.-8. 9.2012

12. Ruiz de Garibay AP, del Pozo-Rodriguez, Solinis MA, Gascon AR. SLN-Based gene

therapy for fabry disease. Protamine and dextran-protamine containing vectors enhance alpha-galactosidase an enzymatic activity in HEPG2 cells. 3rd Retreat of the Center of Pathophysiology, Infectiology and Immunology, Wien 18.-19.9.2012, Program and Abstract Book S 15, SP 5

13. Gajdzik L, Edlmayr J, Valenta R, Blaas D, Fuchs R. Entry of HRV89 involves

dynamin and clathrin. 3rd Retreat of the Center of Pathophysiology, Infectiology and Immunology, Wien 18.-19.9.2012, Program and Abstract Book S 25, SP 15

14. Heindl A, Thalhammer T, Bises G, Schepelmann M, Uhrova H, Rogojanu R,

Seewald A, Ellinger I. Automated recognition of Tissue-associated erythrocytes (ARETE)- A new versatile tool for Tissue-Cytometry. 3rd Retreat of the Center of Pathophysiology, Infectiology and Immunology, Wien 18.-19.9.2012, Program and Abstract Book S 34, SP 24

15. Wagner S, Uhrova H, Ellinger I, Salzer H, Gundacker C. Mercury toxicokinetics in

human term placenta: functional proof and localization of candidate proteins. 3rd Retreat of the Center of Pathophysiology, Infectiology and Immunology, Wien 18.- 19.9.2012, Program and Abstract Book S 80, SP70



41

16. Föger-Samwald U, Rauner M, Kurz MF, Brünner-Kubath C, Kapfenberger A, Varga P, Kudlacek S, Wutzl A, Höger H, Sipos W, Zysset P, Shi GP, Pietschmann P. Cathepsin S deficient mice exhibit a bone and fat phenotype. 3rd Retreat of the Center of Pathophysiology, Infectiology and Immunology, Wien 18.-19.9.2012, Program and Abstract Book S 24, SP 14

17. Heindl A, Dekan S, Rogojanu R, Ecker R, Thalhammer T, Bises G, Uhrova H, Seewald A, Ellinger I (2012). Methods for automated in situ analysis of biomarkers in human placental chorionic tissue- quantification of the receptor for advanced glycated end products (RAGE) in human healthy and pre-eclamptic placentas. 15th IFPA Meeting, Hiroshima, Japan, 18.-21.9.2012.

g) Teaching Scripts and Books: n = 1 1. Pietschmann P. Principles of Osteoimmunology – Molecular Mechanisms and

Clinical Applications. SpringerWienNewYork 2012 h) Articles in Medical Journals: n = 1 1. Pietschmann, P. and U. Föger-Samwald. FRAX® - Was ist das? Skriptum

Kongressjournal der Wiener Medizinischen Wochenschrift 2012; 12:18-19. i) Public activity n = 5 Peter Pietschmann:

1. Interview. “Wir müssen das Armentarium auch einsetzen.” Spectrum Osteoporose 2/2012, S 26-27.

2. Interview bei Radiodoktor, ORF, Ö1, “Osteoporose”, 29.10.2012

Isabella Ellinger:

3. ange Nacht der Forschung: “Eine neue Sicht auf Krankheitsbilder”, 27.4.2012

4. Kinder Uni Wien: “Cell City – Was geht ab in der Zelle”, 10.7.2012

5. Kinder Uni Wien: “Was tut Daniel Düsentrieb? So werkt ein Forscher”, 11.7.2012

1.2.2. Research Awards: n = 7 Dipl.Ing. Andreas Heindl:

- Theodor Körner-Preis 2012 - Poster Award, 3rd Retreat of the Center for Pathophysiology, Infectiology and

Immunology Mag. Ursula Föger-Samwald:

- Walter Doberauer Stipendium für Altersforschung (ÖGGG) - Poster Award, 3rd Retreat of the Center for Pathophysiology, Infectiology and

Immunology Ester Gonzalez-Sanchez:



42

- Poster Award, 8th YSA-PhD- Symposium 2012 Michaela Jungmann:

- Award for reports on Talente Praktika (FFG) Dr. Janina Patsch:

- Herbert Czitober Forschungspreis (ÖGPMR – Österr. Gesellschaft für Physikalische Medizin und Rehabilitation

Mag. Martin Schepelmann: - Poster Award, 3rd Retreat of the Center for Pathophysiology, Infectiology and

Immunology Mag. Silvia Zaussinger:

- Leistungsstipendium für Diplomarbeit

1.2.3. Invited lectures: n = 39 Isabella Ellinger:

1. „A new vista on disease pattern“ Symposium: Bridges in Pathophysiology, MedUniWien, 12.4.2012

2. „Applications and developments in TissueCytometry“, TissueGnostics Distributor

Meeting, 10.10.2012 Renate Fuchs:

3. „Entry of HRV89 involves dynamin and clathrin“. Virus-Cel Interactions, Konnevesi, Finnland, 20.8.2012

Peter Pietschmann:

4. „Biologika in der Gerontoosteologie“. Wissenschaftliche Sitzung der ÖGGG und des LBI für Altersforschung: Biologika in der Geriatrie, Wien, 17.1.2012

5. „Metabolische Chirurgie – Komplikationen erkennen und behandeln: Osteoporose“. 4.

Multidisziplinäres Symposium zur Chirurgie des adipösen Diabetikers, Wien, 24.2.2012

6. „Osteoporose – Bewährtes und neue Therapieoptionen“. ÖÄK Diplomlehrgang

Geriatrie 2.0, Wien, 9.3.2012

7. „Genexpressionsanalytik“. Osteologie 2012 Kongress, Basel, 29.3.2012

8. „Knochen und Fettgewebe – Pathophysioloische Relationen“. Osteologie 2012 Kongress, Basel. 31.3.2012

9. „Introduction to Osteoimmunology“. Symposium „Bridges in Pathophysiology“. MUW Wien, 12.4.2012



43

10. „Bone Phenotype of Obese and Cathepsin S Deficient Mice“. 17. Jahrestagung der Österreichischen Gesellschaft für Endokrinologie und Stoffwechsel (ÖGES), Graz, 19.4.2012

11. „Novel therapies for osteoporosis“. 3. Convegno internazionale di geriatria e gerontologia, Venedig, Italien, 26.4.2012

12. „Pathophysiologisches Modell der altersassoziierten Osteoporose“. 20. Osteoporoseforum der ÖGKM, St. Wolfgang, 10.5.2012

13. „Renovaskuläre Knochenerkrankung“. 20. Osteoporoseforum der ÖGKM, St. Wolfgang, 11.5.2012

14. „Vitamin D: Kardiovaskuläre Aspekte“. 20. Osteoporoseforum der ÖGKM, St. Wolfgang, 12.5.2012

15. „Osteoporose“. Jahrestagung der österr. Gesellschaft für Gynäkologie und Geburtshilfe. Graz, 7.6.2012

16. „Gerontoosteologie“. Osteo ounge: Osteoporosemanagement beim geriatrischen Patienten. Wien, 13.6.2012

17. „Assessment und Therapie von Osteoporosepatienten“. Symposium des BÖPMR „Mobilität im Alter“. Wien, 15.6.2012

18. „Vitamin D: Skelettale und extraskelettale Effekte“. Fortbildungsveranstaltung Universitätsklinik für Frauenheilkunde. Wien, 18.6.2012

19. „Pathophysiology and treatment of osteoporosis“. University of Wisconsin, Madison, USA, 21.8.2012

20. „The Pathophysiology of fat and bone interactions“. University of California, San Francisco, USA, 24.8.2012

21. „Osteoimmunologie – ein pathophysiologischer Link zwischen Knochenstoffwechsel und Inflammation“. 43. ÖGIM 2012, Graz, 21.9.2012

22. „Therapie der Osteoporose beim geriatrischen Patienten“. Fachtag: Polypharmazie und Geriatrie. Wien, 20.10.2012

23. „Klinische Diagnostik“. DVO Grundkurs II – Diagnostik der Osteoporose. Salzburg, 27.10.2012

24. „ abordiagnostik“. DVO Grundkurs II der Osteologie Akademie – Diagnostik der Osteoporose. Salzburg, 27.10.2012

25. „Frakturdiagnostik“. DVO Grundkurs II der Osteologie Akademie – Diagnostik der Osteoporose. Salzburg, 27.10.2012



44

26. „Fallstudien zur Frakturrisikoermittlung und Therapieentscheidung“. DVO Grundkurs II der Osteologie Akademie – Diagnostik der Osteoporose. Salzburg, 27.10.2012

27. „Diagnose der sekundären Osteoporosen und anerer Knochenerkrankungen“. DVO Grundkurs II der Osteologie Akademie – Diagnostik der Osteoporose. Salzburg, 28.10.2012

28. „Fallstudien zur Diagnose der sekundären Osteoporosen und anderer Knochenerkrankungen“. DVO Grundkurs II der Osteologie Akademie – Diagnostik der Osteoporose. Salzburg, 28.10.2012

29. „Future Treatment of Osteoporosis“. 2. International Scientific and Educational Symposium of Bioregenerative Medicine in Slovakia. Bratislava, 8.11.2012

30. „Neues aus der Pathophysiologie“. Management der Osteoporose 2012, Wien, 9.11.2012

31. „Kalzium und Vitamin D in der Knochengesundheit“. 11. Wiener Osteoporosetag, Wien, 9.11.2012

32. „Gerontoosteologie“. Wissenschaftliche Sitzung der ÖGGG und des BI für Altersforschung, Wien, 15.11.2012

33. „Pathophysiologie und Risikofaktoren“. Osteoporose-Kurs, Wien, 23.11.2012

34. „Sekundäre Osteoporosen“. Osteoporose-Kurs, Wien, 23.11.2012

35. „FRAX – Was ist das?“ Jahrestagung der Österreichischen Gesellschaft für Rheumatologie und Rehabilitation, Wien, 24. 11.2012

36. „Bone microarchitecture and local gene expression in elderly men with osteoporotic hip fractures“. International Conference on Progress in Bone & Mineral Research, Wien, 30.11.2012

Theresia Thalhammer:

37. “The role of organic anion transporting polypeptides in ovarian cancer”. 4th International Conference on Drug Discovery & Therapy, Dubai, Vereinigte Arabische Emirate, 12.2.2012-15.2.2012

38. “Nuclear receptors regulate the expression and function of S C-membrane

transporters”. Conference on Nuclear Receptors 2012, Wroclaw, Polen, 6.9.2012

39. “S C-transporters in cancer”. Erasmus Meeting 2012, Sofia, Bulgarien, 17.9.2012



45

1.2.4 Congress organization


National congress Name, date

Function Intern. congress, Name, date

Function

Peter Pietschmann

Wissenschaftliche Sitzung der

Österreichischen Gesellschaft für

Geriatrie und Gerontologie und

des Ludwig Boltzmann-Instituts für Altersforschung,

Wien, 17.1.2012

organisation

Peter Pietschmann

Forum für Geriatrie und Gerontologie „Aktives Altern –

Fakt oder Fiktion?, Bad Hofgastein, Salzburg, 10.3.-

13.3.2012

congress president

Isabella Ellinger,

Peter Pietschmann

Symposium „Bridges in Pathophysiology“,

Wien, 12.4.2012

congress organisation

Andreas Heindl 8th YSA-PhD-Symposium, Wien,

13.-14.6.2012

organising committee

Peter Pietschmann,

Isabella Ellinger, Theresia

Thalhammer

8th YSA-PhD-Symposium, Wien,

13.-14.6.2012

guiding poster

session

Isabella Ellinger 9th WISIA Symposium, Graz,

22.-23.6.2012

Co-organizer

Isabella Ellinger 10th WISIA Symposium, Wien,

23.-24.11.2012

Co-organizer

Peter Pietschmann

International Conference on

Progress in Bone and Mineral Research

2012, Vienna, 29. 11.– 1. 12.2012

organizing committee



Isabella Ellinger Sonja Seewald Sonja Seewald, Steuerberatung 27/01/2012

Isabella Ellinger, Renate Fuchs,

Theresia Thalhammer

Prof. Zdenek Dvorak

Department of Cell Biology and Genetics, Palacky University,

Olomouc, Czech Republic

09/03/2012

Isabella Ellinger, Renate Fuchs, Peter

Pietschmann, Theresia

Thalhammer

Johannes Grillari, PhD

Department of Biotechnology, BOKU Vienna

16/03/2012



46



Thalhammer

Ursula Thiem, MD Depatment of Pathophysiology and Allergy Research, MedUniWien,

Vienna

16/03/2012



Thalhammer

Katharina Kerschan-Schindl, ao.Univ.Prof.Dr.

Universitätsklinik für Physikalische Medizin und Rehabilitation

23/03/2012

Isabella Ellinger Martin Schepelmann,

Mag.

School of Biosciences, University of Cardiff, GB

11/05/2012

Isabella Ellinger, Theresia

Thalhammer

Ester Maria Gonzalez-Sanchez

Laboratory of Experimental Hepatology and Drug Targeting, University of Salamanca, Spain

15/06/2012

Renate Fuchs Prof.Dr. Holland Cheng

Department of Molecular & Cellular Biology, University of California,

Davis, CA, USA

04/09/2012

Isabella Ellinger Prof. Zodwa Dlamini

Florida Science Campus, University of South Africa

05/12/2012



Thalhammer

Lisa Gfrerer, Dr.med.univ.BA

Harvard Medical School, Center of Regenerative Medicine, Harvard

Stem Celll Institute

21/12/2012

1.2.6. Mobility

Name Program University, country

Time frame

Division In Out

Molcan Lubos Ernst-Mach-Stipendium der Aktion Österreich-Slowakei

Comenius University, Faculty of Sciences,

Department of Animal Physiology

and Ethology, Bratislava, Slovakia

01/10/2011-

31/01/2012

2 X

Ester Maria Gonzalez-Sanchez

Programa Nacional de Formacion de Profesorado Universitario

University of Salamanca, Spain

30/04/2012-

31/07/2012

2 X

Malgorzata Kucinska

WTZ Polen-Incoming University of Medical Sciences,

Dept. of Toxicology, Poznan, Polen

01/06/2012 -

06/07/2012

2 X

Danka Obreshkova,

Prof.

Erasmus Programme Medical University Sofia, Faculty of

Pharmacy, Department for Pharmaceutical

Chemistry, Sofia, Bulgarien

10/07/2012 -

13/07/2012

2 X

Aritz Perez Ruiz de Garibay,

Mag.

Research Grant of the Basque Government

Universidad del Pais Vasco, Facultad de

Farmacia, Vitoria-Gasteiz, Spain

27/072012-27/12/2012

2 X



47



Peter Pietschmann Habilitationskommission “konservativ” (Interne, Pädiatrie,

Dermatologie, Radiologie)

Mitglied der Kommission

Peter Pietschmann Bundesministerium für Gesundheit

Beirat für Altersmedizin



Isabella Ellinger Wiener Medizinische Wochenschrift

Guest Editor

Peter Pietschmann Wiener Medizinische Wochenschrift

Associate Editor

Peter Pietschmann Hormone Metabolic Research Member Editorial Board

Peter Pietschmann Zeitschrift für Gerontologie und Geriatrie

Member Editorial Board

Peter Pietschmann Journal für Mineralstoffwechsel Member Editorial Board, Guest editor

Theresia Thalhammer Journal of Drug Delivery (JDD) Guest editor



Isabella Ellinger Foundation for Polish Science – Parent Bridge Program (May 2012)

Peter Pietschmann Deutsche Forschungsgemeinschaft (Grant)

Peter Pietschmann Medizinische Universität Wien – Begutachtung von 2 Habilitationen

Peter Pietschmann Medizinische Universität Wien – Begutachtung 1 PhD Dissertation

Peter Pietschmann Medizinische Universität Wien – Begutachtung 1 MD Dissertation

Theresia Thalhammer Medizinisch-Wissenschftlicher Fonds des Bürgermeisters der Bundeshauptstadt Wien (Grant)

Theresia Thalhammer ÖAD (Grant)

Theresia Thalhammer Slovak Academia of Sciences (Grant)

1.2.10. Filed and granted patents

Name Patent

Isabella Ellinger Austrian Patent (A1444/210) by TissueGnostics Metastrukturerkennung in Geweben



48


Springer Verlag GmbH

Unterstützung der Errichtung und Betreibung eines Editorials Office für die Wiener Medizinische Wochenschrift und der Publikationstätigkeit der Arbeitsgruppe Knochen-, Gender- und Altersforschung.

Peter Pietschmann

SERVIER & ADIR Strontium ranelate effect on osteoblast-induced differentiation and activity through the modulation of RANKL.

Peter Pietschmann

Roche Austria GmbH

Errichtung eines Forschungsnetzwerks auf dem Gebiet der Gerontologie.

Peter Pietschmann

Amgen Cathepsin S in Osteoimmunology: additional studies. Peter Pietschmann

MSD – Merck, Sharp & Dohme

Cathepsin K in Osteoimmunology. Peter Pietschmann

Roche Austria GmbH

Errichtung eines Forschungsnetzwerks auf dem Gebiet der Gerontologie.

Peter Pietschmann

Novartis Pharma GmbH

Bone, Gender und Aging Research. Peter Pietschmann

Ludwig Boltzmann-Institut für Altersforschung

Gene expression and bone microarchitecture in elderly women with osteoporotic hip fractures.

Peter Pietschmann

ÖGGG Gene expression in elderly women. Peter Pietschmann

FFG Bridge Automatisierte Zellerkennungs-Technologien für Forschung und Diagnose.

Isabella Ellinger, Co-Applicant: Theresia Thalhammer, Giovanna Bises

FFG Hg-Transport Teil I – generation innovation Praktika (Talente – Praktika für Schülerinnen und Schüler)

Isabella Ellinger

FFG Hg-Transport Teil II.- generation innovation Praktika (Talente – Praktika für Schülerinnen und Schüler)

Isabella Ellinger

FFG Melatonin/Blutdruck - generation innovation Praktika (Talente – Praktika für Schülerinnen und Schüler)

Isabella Ellinger

Landesklinikum Donauregion Tulln

Mercury toxicokinetics in human term placenta: functional proof and localization of involved candidate proteins.

Applicant: Dr. Claudia Gundacker Co:Applicant: Isabella Ellinger

Medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien

Proteins of the family of “organic anion transporters (OATP) and their potential role in lung and colon cancer therapy.

Theresia Thalhammer (Cooperation:Dr. Buxhofer-Ausch, SMZ-Ost)

Medizinisch-wissenschaftlicher Fonds des Bürgermeisters der Stadt Wien

Identifikation und Validation therapeutischer Targets beim kleinzelligen Lungenkarzinom

Principle Investigator: Theresia Thalhammer (Cooperation Univ.Prof.Dr. Primar Klaus Geissler, Ludwig Boltzmann Institut, KH Hitzing, 5. Med. Abt. mit Onkologie

Ludwig-Boltzmann Institut für Translationale Onkologie

Investigation of genetic and molecular biological characteristics of the tumor cells.

Principle Investigator: T. Thalhammer Koordinator Prof. Robert Zeillinger, Prof. G. Hamilton

FFG Rhinovirus infection - generation innovation Praktika (Talente – Praktika für Schülerinnen und Schüler)

Renate Fuchs

FFG Rhinovirus entry - generation innovation Praktika (Talente – Praktika für Schülerinnen und Schüler)

Renate Fuchs



49

1.2.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0 c) Professorships: n = 0

1.2.13. Teaching a) Bachelor students: n = 1 Peter Pietschmann: Sonja Dorfer, FH Campus Vienna, Bachelor study: Biomedizinische Analytik, 22/02/2012 – 31/07/2012 b) Diploma, MDiploma and Master students: n = 28 Renate Fuchs: Jalali Manuel: MDiploma Thesis. Mechanismus von Virusinfektionen: Einfluß von Ethylisopropylamilorid auf die Infektion von HRB89. (07/2011 – in progress). Medical University of Vienna OTTO Julian: MDiploma Thesis: Rolle der Clathrin-abhängigen Endozytose im Infektionsmechanismus des humanen Rhinovirus 89 (06/2012 – in progress), Medical University of Vienna Spanberger Thomas: MDiploma Thesis. Mechanismus von Virusinfektionen. (05/2009 – in progress), Medical University of Vienna. Isabella Ellinger: Habringer Pia: MDiploma Thesis: Studying the effects of the RAGE-ligands advanced glycation end products (AGEs) on the expression level of the RAGE-variants full length RAGE and soluble RAGE (flRAGE and sRAGE) in trophoblast-like BeWo cells. (05/2012 – in progress) Medical University of Vienna Schaffhauser Martin: MDiploma Thesis. Investigating the contribution of the receptor for advanced glycation end products (RAGE) to the gestational disorder pre-eclampsia: do RAGE-ligands S100 calcium-binding and High Mobility Group Box 1 affect the expression of RAGE-protein variants flRAGE and sRAGE in trophoblast-like BeWo cells? (05/2012 – in progress) Medical University of Vienna



50

Peter Pietschmann: Alaghebandan Afarin: MDentDiploma Thesis: Knochen-Histomorphometrie bei Männern mit osteoporotischen Hüftfrakturen (03/2012 – in progress) Medical University of Vienna Diebler Julian: MDiploma Thesis. Effekte verschiedener BMP-Kombinationen auf murine Osteoklasten und Osteoblasten in der Zellkultur (11/2011 – 06/2012). Medical University of Vienna Kapfenberger Andrea: Diploma (Master) Bioverfahrenstechnik: Einfluss von Cathepsin S auf Knochenstruktur und adipozytäre Differenzierung. (10/2012 – in progress) University of Applied Sciences (FH Campus Vienna) Kurz Michael: MDiploma Thesis. Knochenveränderungen bei Cathepsin S Knockout-Mäusen. (01/2010 – 07/2012) Medical University of Vienna Mayr Helene: MDiploma Thesis. Knochenhistomorphometrie bei einer experimentellen Osteoporosetherapie. (01/2009 –03/2012), Medical University of Vienna. Mukaddam Sena: MDentDiploma Thesis. Knochenstruktur bei Morbus Paget: Analyse von historischen Knochenmaterial mittels HRpQCT (10/2008 – 02/2012). Medical University of Vienna Ortner Nadine: Diploma Microbiology and Immunology. Osteomacrophages in cathepsin S knock out mice (11/2011 – 08/2012) University of Vienna. Sillipp Josef: MDiploma Thesis. Development and evaluation of an automatic method for bone histomorphometry. (05/2010 – 05/2012)Medical University of Vienna Umar Zahra: MDiploma: Wirkung von Osteoprotegerin-Fc auf Knochenstruktur und Knochenumbau beim Schwein (Sus scrofa) (08/2012 – in progress). Medical University of Vienna Theresia Thalhammer: Awad Madonna: DiplomaGenetic. OATP-Proteine in soliden Tumoren (04/2011 – 12/2012) University of Vienna Burger Kathrin: DiplomaPharm Thesis. Einfluß von Melatonin auf das Wachstum von Osteoklasten: Untersuchungen mittels eines neuen automatisierten Imageanalysesystems. (09/2010 – 01/2012). University of Vienna. Durmaz Yasemin: DiplomaPharm Thesis. Expression von Enzymen und Transportproteinen in Tumorzellen und Geweben: Bedeutung für die Therapie. (09/2011 – in progress). University of Vienna



51

Eskandari Hamidreza: MDiploma thesis: Studies on the expression of organic anion transport polypeptides in human cell lines (11/2008 – in progress), Medical University of Vienna. Gründsteidel Johann: MDiploma thesis: Prostaglandin transporting OATPs in ovarian cancer. (10/2010 – in progress). Medical University of Vienna Klameth Lukas: Diploma Biology: pH- regulation in tumors. (03/2012 – in progress) University of Vienna Larijani Aida: DiplomaPharm: OATP Transporter in soliden Tumoren. (03/2012 – in progress) University of Vienna Ndue Leonard: MDiploma.Cyclooxygenase-2 Expression beim fortgeschrittenen Ovarialkarzinom. Korrelation mit klinischen Daten (07/2011 – in progress). Medical University of Vienna Sultan Sirag: MDiploma: Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle des Prostaglandintransporters OATP2A1 (07/2011 – in progress). Medical University of Vienna Türkay Emel: MDiploma thesis. Expression of the transporter OATP 5A1 in normal and malignant human tissue. (11/2008 – in progress), Medical University of Vienna. Zakaria Susanna: DiplomaPharm Thesis. Proteins of the family of „organic anion transporters (OATP)“ and their potential role in lung and colon cancer therapy. (09/2010 – 06/2012). University of Vienna. Zaussinger Siliva: DiplomaPharm Thesis. Charakterisierung eines neuen OATPs (LS-3TM12) in Lebertumoren: Bedeutung für die Tumortherapie. (09/2010 – 04/2012). University of Vienna. Zhang Wenyi: MDiploma thesis.Prostaglandin-Homöostase beim Ovarialkarzinom – Rolle des Transporters MRP4. (05/2011 – in progress). Medical University of Vienna Zotter Simone: DiplomaPharm: Expression von Transportproteinen in Tumorproben von Patienten (10/2012 – in progress). University of Vienna c) PhD, MDSci, MD students: n = 8 Isabella Ellinger: Heindl Andreas, Dipl.Ing: PhD Thesis. Automated cell detection technologies for science and diagnostics (03/2009 – 12/2012), Medical University of Vienna



52

Peter Pietschmann: Azizi-Semrad Ursula: MD Thesis. Extended cytokine profiling of functional human peripheral blood CD4+ T lymphocytes (Th1, Th2 and Th17) and the effect of different micro-environments on their differentiation. (11/2007 – 11/2012). Medical University of Vienna. Gfrerer Lisa: PhD (Doctor of Philosophy N094): Functional analysis of IRF6 and SPECC1l in Zebrafish models of orofacial cleft (12/2012 – in progress) Medical University of Vienna Maldonado-Gonzalez Eduardo: PhD Thesis. The role of Serotonin transporter (5-HTT) and insulin degrading enzyme (IDE) Polymorphism in vascular diseases (05/2011 – in progress) Medical University of Vienna. Theresia Thalhammer: Terezia Kiskova: PhD Thesis. Physiology of animal sciences – studies on chemical induced breast cancer in rats. (02/2011 – 07/2012) Pavol Jozef Safárik University, Kosice Rentsen Erdentetsetseg: PhD Thesis. Identifikation und Validation therapeutischer Targets beim kleinzelligen Lungenkarzinom. (11/2011 – in progress) Medical University of Vienna Riha Juliane, Mag.pharm: PhDPharm Thesis. Metebolismus und Transport neuer Zytostatika in humanen Tumorzelllinien in Gewebe (10/2009 – in progress), University of Vienna.

Rogojanu Radu: PhD Thesis. Automatic recognition of tumor areas in colon cancer (03/2009 – in progress). practical training for study: Isabella Ellinger: KRSTIC Denis, Höhere Technische Bundeslehr- und Versuchsanstalt für chemische Industrie, Rosensteingasse, October 24, 2012 – December 12, 2012 POZDENA Christoph, Höhere Technische Bundeslehr- und Versuchsanstalt für chemische Industrie, Rosensteingasse, October 24, 2012 – December 12, 2012 Peter Pietschmann: LAMM Christiane, Universität Wien Wahlbeispiel im Studienplan Molekulare Mikrobiologie und Immunologie, Schwerpunktfach Immunologie, December 3, 2012 – February 1, 2013 Theresia Thalhammer: Schölm Madeleine, Masterstudienlehrgang “Biotechnologisches Qualitätsmanagement”, November 22, 2011 – June 30, 2012



53

summer practical training: Isabella Ellinger: GRBIC Stefan, Höhere Technische Bundeslehr- und Versuchsanstalt für chemische Industrie, Rosensteingasse, July 2 – 27, 2012 JUNGMANN Michaela, Höhere Technische Bundeslehr- und Versuchsanstalt für chemische Industrie, Rosensteingasse, July 2 – 27, 2012 POZDENA Christoph, Höhere Technische Bundeslehr- und Versuchsanstalt für chemische Industrie, Rosensteingasse, July 2 – 27, 2012 Renate Fuchs: KUHN Lena, Höhere Technische Bundeslehr- und Versuchsanstalt für chemische Industrie, Rosensteingasse, July 2 – 27, 2012 LEWANDOWSKY Dawid, Höhere Lehr- und Versuchsanstalt für Textilindustrie und Datenverarbeitung, Spengergasse, July, 30 – August, 24, 2012 d) Further teaching activities: Peter Pietschmann: Coordinator of the Doctoral program “Bone and Joint Regeneration” (Medical University of Vienna)

1.2.14. Exams a) Oral examinations: n = 6 b) Diploma and Thesis-Examinations: n = 15 Peter Pietschmann: Biljana Radovanovic, MDent Diploma Examination, 14.3.2012 Laleh Nikpournovri, MDent Diploma Examination, 14.3.2012 Nicola Thomsen, MDent Diploma Examination, 14.2.2012 Tobias Wich-Herrlein, MDent Diploma Examination, 14.2.2012 Dr. Bernhard Pommer, Doctoral Examination (N790), 26.6.2012 Helene Mayr, MD Diploma Examination, 28.3.2012 Josef Sillipp; MD Diploma Examination, 23.5.2012 Michael Kurz, MD Diploma Examination, 27.7.2012 DI Andreas Heindl, MD Thesis Examination, 20.12.2012 Sena Mukaddam, MDent Diploma Examination, 20.2.2012 Isabella Ellinger: Helene Mayr, MD Diploma Examination, 28.3.2012 Josef Sillipp; MD Diploma Examination, 23.5.2012 Michael Kurz, MD Diploma Examination, 27.7.2012



54

DI Andreas Heindl, MD Thesis Examination, 20.12.2012 Theresia Thalhammer: Sena Mukaddam, MDent Diploma Examination, 20.2.2012 c) Exam supervising: n = 2 Isabella Ellinger: SSM2, 15/03/2012 SSM1, 07/12/2012 d) Reviewing of Doctoral Thesis: n = 0



55

1.2.15. Lectures, Seminars, Lab SWST pro-rata LV Nr.

SS 2012 MUW Ellinger Isabella 2.27 0.80 802001 BL 4 - Funktionssysteme und biologische Regulation

Ellinger Isabella 2.27 0.75 806021 SSM 2 - Methoden der zellulären Pathophysiologie

Ellinger Isabella 4.00 1.00 808004 SSM 3-Projektstudie (Wahlpflichtteil)

Ellinger Isabella 1.00 0.34 860005 Creative and critical Journal Club II

Ellinger Isabella 2.00 0.50 860006 Journal Club and Progress Report II

Fuchs Renate 2.27 1.87 802001 BL 4 - Funktionssysteme und biologische Regulation

Fuchs Renate 2.27 0.76 806021 SSM 2 - Methoden der zellulären Pathophysiologie

Fuchs Renate 4.00 0.50 808004 SSM 3-Projektstudie (Wahlpflichtteil)

Fuchs Renate 2.00 0.50 860006 Journal Club and Progress Report II

Pietschmann Peter 2.00 0.13 870201 Medical Propedeutics II - Anatomy & Physiology

Pietschmann Peter 2.53 0.40 804000 BL 10 - Endokrinologie und Stoffwechsel

Pietschmann Peter 2.27 0.76 806021 SSM 2 - Methoden der zellulären Pathophysiologie

Pietschmann Peter 4.00 0.50 808004 SSM 3-Projektstudie (Wahlpflichtteil)

Pietschmann Peter 2.00 0.20 850101 Basic Seminar

Pietschmann Peter 2.00 1.00 850102 Thesis Seminar (TS Bones and Joint Regeneration SS 2012)

Pietschmann Peter 1.00 0.13 850103 Journal Club (JC Bones and Joint Regeneration SS 2011)

Pietschmann Peter 1.00 0.34 860005 Creative and critical Journal Club II

Pietschmann Peter 2.00 0.07 860053 JC Endocrinology and Metabolism "SS12" (Pflichtfach)

Pietschmann Peter 2.00 0.07 860055 TS Endocrinology and Metabolism - SS12 (Wahlpflichtfach)

Pietschmann Peter 2.00 0.13 860220 Basisvorlesung Immunologie

Pietschmann Peter 2.00 0.07 860956 PS: "Clinical Endocrinology, Metabolism and Nutrition II (Wahpflichtfach, compulsatory optional course

Pietschmann Peter 5.00 1.60 648015 Anleitung zu wissenschaftlichen Arbeiten - (Wahlfachausbildung gem. § 13/1 lit.a StG.)

Schamall Doris 3.20 1.16 804008 Organmorphologie I

Thalhammer Theresia 1.00 1.50 806009 Ärztliche Gesprächsführung B

Thalhammer Theresia 2.00 0.50 860006 Journal Club and Progress Report II

Thalhammer Theresia 5.00 4.00 514032 Wissenschaftliches Arbeiten - Pathophysiologie der Wirkung von Umweltgiften

Thalhammer Theresia 5.00 1.00 514032 Wissenschaftliches Arbeiten - Pathophysiologie der Wirkung von Umweltgiften

Sum 20.58



56

WS 2012/13 MUW Ellinger Isabella 1.13 2.13 801001 BL 1 - Gesunde und kranke Menschen

Ellinger Isabella 1.07 0.93 801004 BL 2 - Der menschliche Körper

Ellinger Isabella 1.73 1.87 801006 BL 3 - Vom Molekül zur Zelle

Ellinger Isabella 0.50 0.53 803001 BL 7 - Wissenschaft und Medizin (SSM 1)

Ellinger Isabella 1.00 1.00 800000 Senior-Mentoring Humanmedizin

Ellinger Isabella 1.00 0.33 860030 Creative and critical Journal Club III

Ellinger Isabella 1.00 0.25 860031 TS: Stimulating Friday Seminar

Fuchs Renate 2.27 0.27 805002 BL 14 - Niere und Homöostase

Fuchs Renate 1.73 4.27 801006 BL 3 - Vom Molekül zur Zelle

Fuchs Renate 1.13 3.07 801001 BL 1 - Gesunde und kranke Menschen

Fuchs Renate 6.27 1.13 801005 BL 3 - Vom Molekül zur Zelle

Fuchs Renate 2.00 0.20 562019 BVo: Immunologie

Fuchs Renate 2.50 2.50 803051 SSM 1 - Mechanismus von Virusinfektionen

Fuchs Renate 1.00 0.25 860031 TS: Stimulating Friday Seminar

Fuchs Renate 2.00 0.14 618002 Journal Club/Progress Reports III : Molecular Mechanisms in Cell Biology

Pietschmann Peter 5.87 1.20 825001 BL Z-1 Kau- und Bewegungsapparat

Pietschmann Peter 4.00 0.27 807002 BL 21 - Bewegung und Leistung, Schmerz

Pietschmann Peter 4.53 0.13 807009 BL 22/23 - Public Health

Pietschmann Peter 5.80 0.40 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Pietschmann Peter 2.00 0.70 653346 Dissertantenseminar: Durchflusszytometrie - Methodik und immunologische Anwendungsmöglichkeiten

Pietschmann Peter 2.50 1.25 803069 SSM 1 - Knochenerkrankungen - Von der Wissenschaft in die Praxis

Pietschmann Peter 1.00 0.13 850081 Journal Club (Doctoral Program N790 "Bones and Joint Regeneration")

Pietschmann Peter 2.00 1.00 850082 Thesis Seminar (Doctoral Program N790 "Bones and Joint Regeneration")

Pietschmann Peter 1.00 1.00 850085 Journal Club (Creative and Critical Journal Club)

Pietschmann Peter 2.00 0.32 850101 Basic Seminar

Pietschmann Peter 2.00 0.25 850971 Practical Seminar (Doctoral Program N790 "Bones and Joint Regeneration")

Pietschmann Peter 2.00 0.07 860014 TS Endocrinology and Metabolism

Pietschmann Peter 2.00 0.07 860015 JC Endocrinology and Metabolism

Pietschmann Peter 2.00 0.07 860016 Basic Seminar "Endocrinology and Metabolism I" (Wahlpflichtfach)

Pietschmann Peter 1.00 0.33 860030 Creative and critical Journal Club III

Pietschmann Peter 1.00 0.25 860031 TS: Stimulating Friday Seminar

Pietschmann Peter 2.00 2.00 648801 Experimentelle Arbeitstechniken in der Osteologie



57

Pietschmann Peter 5.00 0.50 514053 Anleitung zu wissenschaftlichen Arbeiten - (Wahlfachausbildung gem. § 13/1 lit.a StG.)

Pietschmann Peter 1.00 1.00 520419 Pathophysiologie und Klinik der metabolischen Osteopathien

Pietschmann Peter 10.00 10.00 520711 Wissenschaftliche Arbeiten auf dem Gebiet der metabolischen Osteopathien

Pietschmann Peter 1.00 1.00 561277 Pathophysiologie der rheumatischen Erkrankungen

Thalhammer Theresia 2.00 0.07 860014 TS Endocrinology and Metabolism WS 2012

Thalhammer Theresia 2.00 0.07 860015 JC Endocrinology and Metabolism WS 2012

Thalhammer Theresia 2.00 0.07 860016 Basic Seminar "Endocrinology and Metabolism I" (Wahlpflichtfach)

Thalhammer Theresia 1.00 0.25 860031 TS: Stimulating Friday Seminar

Sum 41.27 Total sum SS+WS MUW 61.85

WS 2012/13 Veterinary University of Vienna Komparative Medizin Ellinger Isabella 2.00 0.13 Cell Development

Ellinger Isabella 2.00 0.14 Human pregnancy and reproduction

Pietschmann Peter 2.00 0.13 Skeleton and bones, human aspects

62.25


Immunpathology

58

1.3. Division for Immunpathology Head: Rudolf Valenta, MD, Professor

1. Publications6 pro-rata IF Number Top/Std/Subst

Valenta Rudolf 112.586 30 22 Top, 6 St.

2 noch kein IF

Flicker Sabine 3.205 1 0 Top, 1 St.

Focke-Tejkl Margarete 7.510 4 4 Top, 0 St.

Linhart Birgit 14.935 4 2 Top, 2 St.

Vrtala Susanne 31.503 6 5 Top, 1 St.

Division-Sum 115.899 29 21 Top, 6 St.

2 noch kein IF





Valenta Rudolf 1 1 7 Flicker Sabine 0 0 3 Focke-Tejkl Margarete 0 1 0 Linhart Birgit 0 1 1 Vrtala Susanne 0 0 2

Sum 1 3 13


Valenta Rudolf 24.80 18.93 43.73 2 Flicker Sabine 0.50 0,50 1.00 1 Focke-Tejkl Margarete 5.00 4.77 9.77 0 Linhart Birgit 2.50 0.77 3.27 0 Vrtala Susanne 4.00 5.77 9.77 1

Sum 36.80 30.74 67.54 4




Immunpathology

59

1.3.1. Publications a) Peer-reviewed original articles: n= 24 Nr. Article IF Class pro-rata IF

1. Valent, P., C. Akin, M. Arock, K. Brockow, J. H. Butterfield, M. C. Carter, M. Castells, L. Escribano, K. Hartmann, P. Liebermann, B. Nedoszytko, A. Orfao, L. B. Schwartz, K. Sotlar, W. R. Sperr, M. Triffiani, R. Valenta, H.-P. Horny, and D. D. Metcalfe*. 2012. Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal. Int. Arch. Allergy Immunol. 157:215-225; DOI: 10.1159/000328760

2.403 St. 0.481

2. Niespodziana, K., K. Napora, C. Cabauatan, M. Focke-Tejkl, W. Keller, V. Niederberger, M. Tsolia, I. Christodoulou, N. G. Papadopoulos, and R. Valenta. 2012. Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections. FASEB J. 26: 1001-8; DOI: 10.1096/fj.11-193557.

5.712

T. 5.712

3. Bousquet, J., L. Heinzerling, C. Bachert, N. G. Papadopoulos, P. J. Bousquet, P. G. Burney, G. W. Canonica, K. H. Carlsen, L. Cox, T. Haahtela, K. C. Lodrup Carlsen, D. Price, B. Samolinski, F. E. Simons, M. Wickman, I. Annesi-Maesano, C. E. Baena-Gagnani, K. C. Bergmann, C. Bindeslev-Jensen, T. B. Casale, A. Chiriac, A. A. Cruz, R. Dubakiene, S. R. Durham, W. J. Fokkens, R. Gerth-van-Wijk, O. Kalayci, M. L. Kowalski, A. Mari, J. Mullol, L. Nazamova-Baranova, R. E. O´Hehir, K. Ohta, P. Panzner, G. Passalacqua, J. Ring, B. Rogala, A. Romano, D. Ryan, P. Schmid-Grendelmeier, A. Todo-Bom, R. Valenta, S. Woehrl, O. M. Yusuf, T. Zuberbier, and P. Demoly; Global Allergy and Asthma European Network; Allergic rhinitis and its impact on asthma. 2012. Practical guide to skin prick tests in allergy to aeroallergens. Allergy. 67:18-24; DOI: 10.1111/j.1398-9995.2011.02728.x.

6.271

T. 1.254

4. Blatt, K., H. Herrmann, I. Mirkina, E. Hadzijusufovic, B. Peter, S. Strommer, G. Hoermann, M. Mayerhofer, K. Hoetzenecker, W. Klepetko, V. Ghanim, K. Marth, T. Füreder, V. Wacheck, R. Valenta, and P. Valent. 2012. The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils. PLoS One. 7:e29925; DOI: 10.1371/journal.pone.0029925.

4.092

T. 0.818

5. WHO collaborating center for asthma and rhinitis, Bousquet, J., J. M. Anto, P. Demoly, H. J. Schünemann, A. Togias, M. Akdis, C. Auffray, C. Bachert, T. Bieber, P. J. Bousquet, K. H. Carlsen, T. B. Casale, A. A. Cruz, T. Keil, K. C. Lodrup-Carlsen, M. Maurer, K. Ohta, N. G. Papadopoulos, M. R. Rodrigues, B. Samolinski, I. Agache, A. Andrianarisoa, I. Annesi-Maesano, F. Ballester, C. E. Baena-Cagnani, X. Basagafia, E. D. Bateman, O. E. H.

2.403 St. 0.481


Immunpathology

60

Bel, A. Bedbrook, B. Beghue, M. Beji, A. Ben Kheder, M. Benet, K. S. Bennoor, K. C. Bergmann, R. Berrissoul, C. Bindslev Jensen, Bleecker S. Bonini, A. L. Boner, L. P. Boule, C. E: Brightling, J. L.Broze, A. Bush, W. W. Busse, P. A. M. Camargos, G. W. Canonica, W. Carr, A. Cesario, Y. Z. Chen, A. Chin-Suorn, A. Chiriac, D. J. Costa, L. Cox, A. Custovic, R. Dahl, U. Darsow, T. Didi, W. K. Dolen, H. Douagui, R. Dubakiene, A. El-Meziane, J. Fonseca, W. J. Fokkens, E. Fthenou, A. Gamkrelidze, J. Garcia-Aymerich, R. Gerth van Wijk, E. Gimeno, S. Guerra, T. Haahtela, H. Haddad, P. Hellings, B. Hellquist-Dahl, C. Hohmann, P. Howarth, J. O. Hourihane, M. Humbert, B. Jacquemin, J. Just, O. Kalayci, M. A. Kaliner, F. Kauffmann, M. Kerkhof, G. Khayat, B. Koffi, N´Goran, M. Kogevinas, G. H. Koppelman, M. L. Kowalski, I. Kull, P. Kuna, D. Larenas, I. Lavi, L. T. Le, P. Lieberman, B. Lipworth, B. Mahboub, M. J. Makela, F. Martin, F. D. Martinez, G. D. Marschall, A. Mazon, E. Melen, E. O. Meltzer, F. Mihaltan, Y. Mohammed, A. Mohammadi, I. Momas, M. Morais-Almeida, J. Mullol, A. Murano, R. Naclerio, S. Nafti, L. Namazova-Baranova, M. C. Nawijn, D. Nyembue, S. Oddie, R. O´Hehir, Y. Okamoto, M. P. Orru, C. Ozdemir, G. S. Ouedroago, S. Palkonen, P. Panzer, G. Passalaqua, R. Pawankar, B. Pigearias, I. Pin, M. Pinart, C. Pison, T. A. Popov, D. Porta, D. S. Postma, D. Price, K. F. Rabe, J. Ratomahoro, S. Reitam, D. Rezagui, J. Ring, R. Roberts, J. Roca, B. Rogala, A. Romano, J. Rosaro-Pinto, D. Ryan, M. Sanchez-Borges, G. K. Scadding, A. Sheikh, F. E. R. Simons, V. Siroux, P. Schmidt-Gredelmeier, H. A. Smit, T. Sooronbaev, R. T. Stein, P. J. Sterk, J. Sunyer, I. Terreehorst, E. Toskala, Y. Tremblay, R. Valenta, D. Valeyre, O. Vandenplas, C. van Weel, M. Vassilaki, R. Varraso, G. Viegi, D. Y. Wang, M. Wickman, D. Williams, S. Wöhrl, J. Wright, A. Yorgancioglu, O. M. Yusuf, H. J. Zar, M. E. Zernotti, M. Zidarn, N. Zhong, and T. Zuberbier. In collaboration with the WHO Collaborating Center for Asthma and Rhinitis. 2012. Severe chronic allergic (and related) diseases: a uniform approach – a MeDALL-GA²LEN-ARIA position paper. Int. Arch. Allergy Immunol. 158:216-231; DOI: 10.1159/000332924

6. Pahr, S., C. Constantin, A. Mari, S. Scheiblhofer, J. Thalhamer, C. Ebner, S. Vrtala, I. Mittermann, and R. Valenta. 2012. Molecular characterization of wheat allergens specifically recognized by patients suffering from wheat-induced respiratory allergy. Clin. Exp. Allergy. 42: 597-609; DOI: 10.1111/j.1365-2222.2012.03961.x.

5.032

T. 5.032

7. Twaroch, T. E., E. Arcalís, K. Sterflinger, E. Stöger, I. Swoboda, and R. Valenta. 2012. Predominant localization of the major Alternaria allergen Alt a 1 in the cell wall of airborne spores. J. Allergy Clin. Immunol. 129: 1148-1149; DOI: 10.1016/j.jaci.2011.10.008

11.003

T. 11.003


Immunpathology

61

8. Zuidmeer-Jongejan, L., M. Fernandez-Rivas, L. K. Poulsen, A. Neubauer, J. Asturias, L. Blom, J. Boye, C. Bindslev-Jensen, M. Clausen, R. Ferrara, P. Garosi, H. Huber, B. M. Jensen, S. Koppelman, M. L. Kowalski, A. Lewandowska-Polak, B. Linhart, B. Maillere, A. Mari, A. Martinez, C. E. Mills, C. Nicoletti, D. J. Opstelten, N. G. Papadopoulos, A. Portoles, N. Rigby, E. Scala, H. J. Schnoor, S. Sigursdottir, G. Stavroulakis, F. Stolz, I. Swoboda, R. Valenta, R. van den Hout, S. A. Versteeg, M. Witten, and R. van Ree. 2012. FAST: Towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies. Clin. Transl. Allergy. 2:5; DOI: 10.1186/2045-7022-2-5.

9. Eckl-Dorna, J., A. Ellinger, K. Blatt, V. Ghanim, I. Steiner, M. Pavelka, P. Valent, V. R. Valenta, and V. Niederberger. 2012. Basophils are not the key antigen-presenting cells in allergic patients. Allergy. 67: 601-8; DOI: 10.1111/j.1398-9995.2012.02792.x.

6.271

T. 6.271

10. Chen, K-W., M. Focke-Tejkl, K. Blatt, M. Kneidinger, A. Gieras, F. Dall´antonia, I. Faé, G. Fischer, W. Keller, P. Valent, R. Valenta, and S. Vrtala. 2012. Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients. Allergy. 67: 609-21; DOI: 10.1111/j.1398-9995.2012.02794.x

6.271

T. 6.271

11. Sibanda, E., D. Gallerano, E. Wollmann, and R. Valenta. 2012. EFIS-EJI African International Conference on Immunity (AICI). Eur J Immunol. 42: 1070-1071; DOI: 10.1002/eji.2012700025.

5.103

T. 5.103

12. Herrmann, H., K. Blatt, V. Ghanim, M. Kneidinger, K. Marth, R. Valenta, and P. Valent. 2012. Glucocorticosteroids rescue basophils from dasatinib-augmented immunoglobulin E-mediated histamine release. Int. Arch. Allergy Immunol. 159: 15-22; DOI: 10.1159/000335146.

2.403 St. 0.481

13. Casset, A., A. Mari, A. Purohit, Y. Resch, M. Weghofer, R. Ferrara, W. R. Thomas, C. Alessandri, K.-W. Chen, F. de Blay, R. Valenta, and S. Vrtala. 2012. Varying allergen composition and content affects the in vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts. Int. Arch. Allergy Immunol. 159: 253-262; DOI: 10.1159/000337654

2.403 St. 2.403

14. Baranyi, U., N. Pilat, M. Gattringer, B. Linhart, C. Klaus, E. Schwaiger, J. Iacomini, R. Valenta, and T. Wekerle. 2012. Persistent molecular microchimerism induces long-term tolerance towards a clinically relevant respiratory allergen. Clin Exp. Allergy. 42: 1282-92; DOI: 10.1111/j.1365-2222.2012.04049.x.

5.032

T. 1.006

15. Calderon, M. A., P. Demoly, R. Gerth van Wijk, J. Bousquet, A. Sheikh, A. Frew, G. Scadding, C. Bachert, H. J. Malling, R. Valenta, B. Bilo, A. Nieto, C. Akdis, J. Just, C. Vidal, E. M. Varga, E. Alvarez-Cuesta, B. Bohle, A.


Immunpathology

62

Bufe, W. G. Canonica, V. Cardona, R. Dahl, A. Didier, S. R. Durham, P. Eng, M. Fernandez-Rivas, L. Jacobsen, M. Jutel, J. Kleine-Tebbe, L. Klimek, J. Lötvall, C. Moreno, R. Mosges, A. Muraro, B. Niggemann, G. Pajno, G. Passalacqua, O. Pfaar, S. Rak, G. Senna, G. Senti, E. Valovirta, M. van Hage, J. C. Virchow, U. Wahn, and N. Papadopoulos. 2012. EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy. Clin. Transl. Allergy. 2: 20; DOI: 10.1186/2045-7022-2-20

16. Eckl-Dorna, J., I. Pree, J. Reisinger, K. Marth, K-W. Chen, S. Vrtala, S. Spitzauer, R. Valenta, and V. Niederberger. 2012. The majority of allergen-specific IgE in the blood of allergic patients does not originate from blood-derived B cells or plasma cells. Clin. Exp. Allergy. 42: 1347-55; DOI: 10.1111/j.1365-2222.2012.04030.x.

5.032

T. 5.032

17. Twaroch, T., M. Focke-Tejkl, K. Fleischmann, C. Lupinek, K. Blatt, R. Ferrara, A. Mari, C. Ebner, P. Valent, S. Spitzauer, I. Swoboda, and R. Valenta. 2012. Carrier-bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternate allergy. Clin. Exp. Allergy. 42: 966-75; DOI: 10.1111/j.1365-2222.2012.03996.x.

5.032

T. 5.032

18. Chen, K. W., K. Blatt, W. R. Thomas, I. Swoboda, P. Valent, R. Valenta, and S. Vrtala. 2012. Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy. J. Allergy Clin. Immunol. 130:435-443.e4; DOI: 10.1016/j.jaci.2012.05.035

11.003

T. 11.003

19. Korošec, P., R. Valenta, I. Mittermann, N. Celesnik, M. Silar, M. Zidarn, and M. Košnik. 2012. High sensitivity of CAP-FEIA rVesp v 5 and rVesp v 1 for diagnosis of Vespula venom allergy. J. Allergy Clin. Immunol. 129: 1406-8; DOI: 10.1016/j.jaci.2011.12.975.

11.003

T. 2.201

20. McLean, G. R., R. P. Walton, S. Shetty, N. Paktiawal, T. Kebadze, L. Gogsadze, K. Niespodziana, R. Valenta, N. W. Bartlett, and S. L. Johnston. 2012. Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1. Antiviral Research. 95: 193-201; DOI: 10.1016/j.antiviral.2012.06.006

4.301

T. 0.860

21. Baar, A., S. Pahr, C. Constantin, S. Scheiblhofer, J. Thalhamer, S. Giavi, N. G. Papadopoulos, C. Ebner, A. Mari, S. Vrtala, and R. Valenta. 2012. Molecular and immunological characterization of Tri a 36, a low-molecular weight glutenin as a novel major wheat food allergen. J. Immunol. 189: 3018-25; DOI: 10.4049/jimmunol.1200438

5.788

T. 5.788

22. Bousquet, J., H. J. Schünemann, B. Samolinski, P. Demoly, C. E. Baena-Cagnani, C. Bachert, S. Bonini, L. P. Boulet, P. J. Bousquet, J. L. Brozek, G. W. Canonica, T. B. Casale, A. A. Cruz, W. J. Fokkens, J. A. Fonseca, R. Gerth van Wijk, L. Grouse, T. Haahtela, N. Khaltaev, P. Kuna, R. F. Lockey, K. C. Lodrup Carlsen, J. Mullol, R. Naclerio, R. E. O´Hehir, K. Ohta, S. Palkonen, N. G.

11.003

T. 2.201


Immunpathology

63

Papadopoulos, G. Passalacqua, R. Pawankar, D. Price, D. Ryan, F. E. Simons, A. Togias, D. Williams, A. Yorgancioglu, O. M. Yusuf, W. Aberer, M. Adachi, I. Agache, N. Aït-Khaled, C. A. Akdis, A. Andrianarisoa, I. Annesi-Maesano, I. J. Ansotegui, I. Baiardini, E. D. Bateman, A. Bedbrook, B. Beghé, M. Beji, E. H. Bel, A. Ben Kheder, K. S. Bennoor, K. C. Bergmann, F. Berrissoul, T. Bieber, C. Jensen, M. S. Blaiss, A. L. Boner, J. Bouchard, F. Braido, C. E. Brightling, A. Bush, F. Caballero, M. A. Calderon, M. A. Calvo, P. A. Camargos, L. R. Caraballo, K. H. Carlsen, W. Carr, A. M. Cepeda, A. Cesario, N. H. Chavannes, Y. Z. Chen, A. M. Chiriac, T. Pérez Chivato, E. Chkhartishvili, G. Ciprandi, D. J. Costa, L. Cox, A. Custovic, R. Dahl, U. Darsow, F. De Blay, D. Deleanu, J. A. Denburg, P. Devillier, T. Didi, D. Dokic, W. K. Dolen, H. Douagui, R. Dubakiene, S. R. Durham, M. S. Dykewicz, Y. El-Gamal, A. El-Meziane, R. Emuzyte, A. Fiocchi, M. Fletcher, T. Fukuda, A. Gamkrelidze, J. E. Gereda, S. G. Diaz, M. Gotua, M. A. Guzmán, P. W. Hellings, B. Hellquist-Dahl, F. Horak, J. O´B Hourihane, P. Howarth, M. Humbert, J. C. Ivancevich, C. Jackson, J. Jus, O. Kalayci, M. A. Kaliner, A. F. Kalyoncu, T. Keil, P. K. Keith, G. Khayat, Y. Y. Kim, B. Koffi N´goran, G. H. Koppelman, M. L. Kowalski, I. Kull, V. Kvedariene, D. Larenas-Linnemann, L. T. Le, C. Lemière, J. Li, P. Lieberman, B. Lipworth, B. Mahboub, M. J. Makela, F. Martin, G. D. Marshall, F. D. Martinez, M. R. Masjedi, M. Maurer, S. Mavale-Manuel, A. Mazon, E. Melen, E. O. Meltzer, N. H. Mendez, H. Merk, F. Mihaltan, Y. Mohammed, M. Morais-Almeida, A. Muraro, S. Nafti, L. Namazova-Baranova, K. Nekam, A. Neou, B. Niggemann, E. Nizankowska-Mogilnicka, T. D. Nyembue, Y. Okamoto, K. Okobo, M. P. Orru, S. Ouedraogo, C. Ozdemir, P. Panzner, I. Pali-Schöll, H. S. Park, B. Pigearias, W. Pohl, T. A. Popov, D. S. Postma, P. Potter, K. F. Rabe, J. Ratomaharo, S. Reitamo, J. Ring, R. Roberts, B. Rogala, A. Romano, M. Roman Rodrigues, J. Rosado-Pinto, L. Rosenwasser, M. Rottem, M. Sanchez-Borgas, G. K. Scadding, P. Schmid-Grendelmeier, A. Sheikh, J. C. Sisul, D. Solé, T. Sooronbaev, V. Spicak, O. Spranger, R. T. Stein, S. W. Stoloff, J. Sunyer, A. Szczeklik, A. Todo-Bom, E. Toskala, Y. Tremblay, R. Valenta, A. L. Valero, D. Valeyre, A. Valiulis, E. Valovirta, P. Van Cauwenberge, O. Vandenplas, C. van Weel, P. Vichyanond, G. Viegi, D. Y. Wang, M. Wickman, S. Wöhrl, J. Wright, B. P. Yawn, P. K. Yiallouros, H. J. Zar, M. E. Zernotti, N. Zhong, M. Zidarn, T. Zuberbier; in collaboration with the World Health Organization Collaborating Center for Asthma and Rhinitis. 2012. Allergic rhinitis and its impact on asthma (ARIA): achievements in 10 years and future needs. J. Allergy Clin. Immunol. 130:1049-62; DOI: 10.1016/j.jaci.2012.07.053.

23. Lupinek, C.*, K. Marth*, V. Niederberger*, and R. Valenta*. 2012. Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults. J. Allergy Clin Immunol. Aug.

11.003

T. 11.003


Immunpathology

64

3; DOI: 10.1016/j.jaci.2012.06.028.

24. Flicker, S., B. Linhart, C. Wild, U. Wiedermann, and R. Valenta. 2012. Passive immunization with allergen-specific IgG antibodies for treatment and prevention of allergy. Immunobiol. 130: 1418-1420; DOI: 10.1016/j.imbio.2012.10.008

3.205

St. 3.205

sum 131.769 90.819

b) Invited Articles & Reviews with IF: n= 5

Nr. Article IF Class pro-rata IF

1. Linhart, B., and R. Valenta. 2012. Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives. Vaccine. 19; 30(29): 4328-35; DOI: 10.1016/j.vaccine.2011.11.011. Review.

3.766

St. 3.766

2. Antó, J. M., M. Pinart, M. Akdis, C. Auffray, C. Bachert, X. Basagaña, K. H. Carlsen, S. Guerra, L. von Hertzen, S. Illi, F. Kaufmann, T. Keil, J. P. Kiley, G. H. Koppelman, C. Lupinek, F. D. Martinez, M. C. Nawijn, D. S. Postma, V. Siroux, H. A. Smit, P. J. Sterk, J. Sunyer, R. Valenta, S. Valverde, C. A. Akdis, I. Annesi-Maesano, F. Ballester, M. Benet, A. Cambon-Thomsen, L. Chatzi, J. Coquet, P. Demoly, W. Gan, J. Garcia-Aymerich, E. Gimeno-Santos, C. Guihenneuc-Jouyaux, T. Haahtela, J. Heinrich, M. Herr, C. Hohmann, B. Jacquemin, J. Just, M. Kerkhof, M. Kogevinas, M. L. Kowalski, B. N. Lambrecht, S. Lau, K. C. Lødrup Carlsen, D. Maier, I. Momas, P. Noel, S. Oddie, S. Palkonen, I. Pin, D. Porta, A. Punturieri, F. Rancière, R. A. Smith, B. Stanic, R. T. Stein, W. van de Veen, A. J. van Oosterhout, R. Varraso, M. Wickman, C. Wijmenga, J. Wright, G. Yaman, T. Zuberbier, and J. Bousquet; WHO Collaborating Centre on Asthma and Rhinitis (Montpelliert). 2012. Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDaLL) seminar. J. Allergy Clin. Immunol. 129:943-954; DOI: 10.1016/j.jaci.2012.01.047. Review.

11.003

T. 2.201

3. Linhart, B., and R. Valenta. 2012. Vaccines for allergy. Curr Opin Immunol. 24: 354-60; DOI: 10.1016/j.coi.2012.03.006. Review.

9.522

T. 9.522

4. Valenta, R., R. Campana, K. Marth, and M. van Hage. 2012. Allergen-specific immunotherapy: from therapeutic vaccines to prophylactic approaches. J Intern Med. 272: 144-57; DOI: 10.1111/j.1365-2796.2012.02556.x. Review.

5.483

T. 5.483

5. Focke-Tejkl, M., and R. Valenta. 2012. Safety of 4.108 T. 4.108





Immunpathology

65

engineered allergen-specific immunotherapy vaccines. Curr. Opin. Allergy Clin. Immunol. 12: 555-63; DOI: 10.1097/ACI.0b013e328357ca53. Review.

sum 33.882 25.080

c) Invited Articles & Reviews without IF: n = 1 1. Gadermaier, E. In shape- the art of mapping conformational epitopes. Int Arch Allergy

Immunol. 2012;157(4):321-2. doi: 10.1159/000332948 d) Book contributions: n = 0 e) Abstracts, printed in periodicals: n = 0 f) Abstracts, in congress proceedings or abstract books: n = 29 1. B. Linhart, M. Focke-Tejkl & R. Valenta. Vaccination with carrier-bound peptides from

the major birch pollen allergen Bet v 1 lacking allergen-specific T cell epitopes reduces Bet v 1-specific T cell responses. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012

2. C. R. Cabauatan, C Lupinek, R. Weiss, M. Focke-Tejkl, P. L. Bhalla, M. B. Singh, P. A. Knight, M. van Hage, J. D. A. Ramos & R. Valenta. IgE reactivity profiling of allergic individuals in the Philippines. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012

3. D. Gallerano, M. Focke, P. Ndlovu, I. Makupe, E. N. Sibanda & R. Valenta. Dissecting HIV-1 clade C specific antibody responses. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012

4. M. Curin, I. Swoboda, M. Focke, K. Blatt, P. Valent, H. Grönlund, S. Spitzauer & R. Valenta. Design of hypoallergenic derivatives of the major cat allergen Fel d 1 by rational reassembly as a mosaic protein. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012

5. M. Narayanan, M. Focke-Tejkl, R. Valenta & B. Linhart. Evidence for T cell- independent boost of allergen-specific secondary IgE responses by B cell epitopes. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012

6. S. Banerjee, Y. Resch, K. W. Chen, K. Blatt, I. Swoboda, M. Focke-Tejkl, M. van Hage, A. Mari, A. Purohit, G. Pauli, E. N. Sibanda,_ W. Thomas, A. A. Adegnika, V. Krzyzanek, U. Malkus, P. Valent, R. Valenta, S. Vrtala. The IgE-reactivity of Der p 11, the mite paramyosin, differs considerably between certain geographical areas. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012.

7. B. Srinivasan, M. Focke-Tejkl, I. Swoboda, C. Constantin, I. Mittermann, S. Pahr, H. Vogelsang, W.D. Huber, R. Valenta. Identification, characterization and epitope mapping of gamma gliadin, a major wheat antigen in celiac desease. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012.


Immunpathology

66

8. Baar, S. Pahr, C. Constantin, S Giavi, N. Papadopulos, A. Pelkonen, M. Mäkelä, C. Ebner, A. Mari, S. Vrtala, R. Valenta. Isolation, expression and characterization of IgE reactive-portions of high molecular weight glutein like wheat fool allergens. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012.

9. K. Marth, E. Wollmann, D. Gallerano, R. Valenta, E. Sibanda, Persistence of allergen- specific IgE responses in patiens suffering from AIDS. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012.

10. K-W. Chen, K. Blatt, W.R. Thomas, I Swoboda, P. Valent, R. Valenta, S. Vrtala. Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012.

11. S. Pahr, C. Constantin, N. Papadopoulos, S. Giavi, M. Mäkelä, A. Pelkonen, C. Ebner, A. Mari, S. Scheiblhofer, J. Thalhamer, I. Mittermann, S. Vrtala, R. Valenta. Alpha purothionin, a new wheat food allergen, belongs to a family of plant defence proteins. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012.

12. Y. Resch, K. Blatt, U. Malkus, I. Swoboda, S. Seiberler, I. Mittermann, F. Horak, N. Novak, V. Krzyzanek, P. Valent, R. Valenta, S. Vrtala. Molecular and immunological characterization of Der p 18, a chitinase-like house dust mite allergen. 3rd retreat of the Center for Pathophysiology, Infectiology and Immunology, September 18 - 19, 2012.

13. C. Madritsch, S. Flicker, E. Gadermaier, R. Valenta, Conversion of human allergen- specific IgE into therapeutic IgG antibodies. 8th Annual PEGS, Boston, MA, USA, May 2012.

14. C. Madritsch, S. Flicker, E. Gadermaier, R. Valenta. Conversion of human allergen- specific IgE into therapeutic IgG antibodies. ÖGAI Symposium 2012, Klosterneuburg, November 30, 2012.

15. E. Gadermaier, S. Flicker, C. Lupinek, P. Steinberger, R. Valenta. Determination of allergen-specificity by heavy chains in grass pollen allergen-specific IgE antibodies. ÖGAI Symposium 2012, Klosterneuburg, November 30, 2012.

16. E. Gadermaier, S. Flicker, K. Blatt,, P. Valent, R. Valenta. Grass pollen allergen- specific ScFv with therapeutic potential. 8th Annual PEGS, Boston, MA, USA, May 2012.

17. F. Horak, P. Zieglmayer, R. Zieglmayer, P. Lemell, M. Focke-Tejkl, A. Neubauer, J. Klinger, H. Huber, M. Weber, R.Henning, R. Valenta. First in man immunotherapy study with the novel grass pollen allergy vaccine BM32 using the Vienna Challenge Chamber. 29th Symposium of the Collegium Internationale Allergologicum, Jeju Island, Republic of Korea, October 14-19, 2012.

18. H. Hochwallner, A. Scheynius, J. Alm, C. Lupinek, C. Harwanegg, S. Spitzauer, O. Wagner, R. Valenta. Chip-based analysis of IgG against micro-arrayed allergens reveals a correlation of allergen-specific IgG reactivity profiles in human breast milk and blood. EAACI Allergy School, Food Allergy Training Course, Vienna, August 25, 2012.

19. K. Marth, I. Breyer, M. Focke-Tejkl, K. Blatt, Mohamed Shamji, J. Layhadi, A.Gieras I. Swoboda, D. Zafred, Wl. Keller, P. Valent, St. Durham, r. Valenta. Recombinant


Immunpathology

67

fusion proteins consisting of hepatitis PreS-fused non-allergenic Bet v 1 peptides focus blocking IgG towards IgE epitopes and shift T cell responses to a tolerogenic phenotype, ÖGAI Symposium 2012, Klosterneuburg, November 30, 2012.

20. K. Marth, I. Breyer, M. Focke-Tejkl, K. Blatt, Mohamed Shamji, J. Layhadi, A.Gieras I. Swoboda, D. Zafred, Wl. Keller, P. Valent, St. Durham, r. Valenta. Recombinant fusion proteins consisting of hepatitis PreS-fused non-allergenic Bet v 1 peptides focus blocking IgG towards IgE epitopes and shift T cell responses to a tolerogenic phenotype. 29th Symposium of the Collegium Internationale Allergologicum, Jeju Island, Republic of Korea, October 14-19, 2012.

21. K-W. Chen, K. Blatt, W.R. Thomas, I Swoboda, P. Valent, R. Valenta, S. Vrtala. Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy. ÖGAI Symposium 2012, Klosterneuburg, November 30, 2012.

22. M. Narayanan, M. Focke-Tejkl, R. Valenta, B. Linhart. B cell epitopes boost IgE responses in the absence of T cell help. Keystone Symposia on Molecular and Cellular Biology, December 13-18, 2012.

23. S. Banerjee, Y. Resch, K. Chen, I. Swoboda, M. Focke, K. Blatt, M. Hage, A. Mari, A. Purohit, G. Pauli, E. Sibanda, W. Thomas, A. Adegnika, V.Krzyzanek, U. Malkus, P. Valent, R. Valenta, S. Vrtala. Der p 11, the mite paramyosin, is an important allergen only in certain geographical areas. 8th YSA-PhD-Symposium, Vienna, June 13 - 14, 2012.

24. S. Banerjee, Y. Resch, K. Chen, I. Swoboda, M. Focke, K. Blatt, M. Hage, A. Mari, A. Purohit, G. Pauli, E. Sibanda, W. Thomas, A. Adegnika,V.Krzyzanek, U. Malkus, P. Valent, R. Valenta, S. Vrtala. The IgE-reactivity of Der p 11, the mite paramyosin, differs considerably between certain geographical areas.Annual Meeting of the ÖGAI Symposium 2012, Klosterneuburg, November 30, 2012.

25. S. Pahr, C. Constantin, N. Papadopoulos, S. Giavi, M. Mäkelä, A. Pelkonen, C. Ebner, A. Mari, S. Scheiblhofer, J. Thalhamer, I. Mittermann, S. Vrtala, R. Valenta. Alpha purothionin, a new wheat food allergen, belongs to a family of plant defence proteins. EAACI Allergy School, Food Allergy Training Course, Vienna, August 25, 2012.

26. V. Niederberger, J. Eckl-Dorna, K. Marth, M. Focke-Tejkl, M. Weber, R. Henning, A. Neubauer ,R. Valenta. Skin test evaluation of a new vaccine against grass pollen allergy based on recombinant fusion proteins consisting of hepatitis B PreS and peptides from four major grass pollen allergens.. 29th Symposium of the Collegium Internationale Allergologicum, Jeju Island, Republic of Korea, October 14-19, 2012.

27. Y. Resch, K. Blatt, U. Malkus, C. Fercher I. Swoboda, M. Focker, K. Chen, S. Seiberler, I. Mittermann, F. Horak, N. Novak, W. Keller, V. Krzyzanek, P. Valent, R. Valenta, S. Vrtala. The major house dust mite allergen for dogs, Der p 18, is important for mite-allergic humans suffering from atopic dermatitis. Annual Meeting of ÖGAI Symposium 2012, Klosterneuburg, November 30, 2012.

28. Y. Resch, K. Blatt, U. Malkus, I. Swoboda, S. Seiberler, I. Mittermann, F. Horak, N. Novak, V. Krzyzanek, P. Valent, R. Valenta, S. Vrtala. Molecular and immunological characterization of Der p 18, a chitinase-like house dust mite allergen. 3rd European Congress of Immunology, Glasgow, September 5 - 8, 2012.


Immunpathology

68

29. Y. Resch, M. Weghofer, A. Mari, S. Scheiblhofer, M. Focke, J. Thalhamer, R. Valenta, S. Vrtala. The effect of in vitro-gastro-duodenal digestion of the major shrimp allergen tropomyosin on IgE reactivity and allergenic activity. 8th YSA-PhD-Symposium, Vienna, June 13 - 14, 2012.

g) Teaching Scripts and Books: n = 0 h) Articles in Medical Journals: n = 0

i) Public activity: n = 32

1. NEWS LEBEN Nr. 4 Klarheit mit einem Tropfen Blut

2. Ganze Woche Nr. 13 Neuer Test und schnelle Hilfe für Allergiker

3. Der Standard vom 26.03.2013 Jeder Kontakt heizt die Krankheit an

4. Kronen Zeitung "Apfel gegen Birke"

5. Bezirksblätter Osttirol vom 12./22. März 2012 Schnupfen tricks Immunsystem aus

6. healtheconomy vom 16.03.2012 Spritze gegen Kreuzallergien

7. Format 11/12 Gegen Schnupfen nicht immun

8. Die Presse vom 7.03.2012 Vielversprechende Allergieimpfung

9. Die Presse vom 11.03.2012 Schnupfen ist eine zwar unangenehme, aber eigentlich

harmlose Krankheit: diese althergebrachte Weisheit wird nun in einem großen EU-

Projekt hinterfragt.

10. Wiener Zeitung vom 8.03.2012 Immer wieder Schnupfen?

11. Leben Nr. 68 vom 8.03.2013 Immer wieder Schnupfen

12. Salzburger Nachrichten vom 8.03.2012 Gegen Schnupfen nicht immun

13. Die Presse vom 8.03.2012 Schnupfen: Keine Immunität

14. Kurier vom 8.03.2012 Immunabwehr ist bei Schnupfen fehlgeleitet

15. Leben vom 7.03.2012 Kreuzallergie auf der Spur

16. Salzburger Nachrichten vom 7.03.2012 Impfung gegen Kreuzallergie

17. Leben vom 6.03.2012 Chip soll Allergie erkennen

18. Kurier vom 6.03.2012 Allergie: Diagnose mir einem Blutstropfen

19. Kronen Zeitung vom 6.03.2012 Mittels Chip Allergie früh erkennen

20. Wiener Zeitung vom 6.03.2012 Pollen blasen zum Angriff

21. Kurier vom 5.03.2012 Allergien: Infotag an der MedUni Wien

22. APA-Journal vom 5.03.2012 Für Allergiediagnostik reicht ein Blutstropfen

23. APA-Journal vom 02.03.2012 Allergie-Informationstag der MedUni Wien

24. oe1.ORF.at am 10.05.2012 Ein Jahr Forschungsstrategie

25. News vom 06.03.2012 Hoffnung für Allergiker

26. Madonna vom 10.05.2012 Per Blutstropfen zur Allergiediagnose

27. derstandard vom 06.03.2012 Allergien: Hoffnung für 400.000 Österreicher

28. derstandard vom 05.03.2012 Ein Blutstropfen reicht für die Allergie-Diagnose

29. Kleine Zeitung vom 08.03.2012 Achtung! Pollen im Anflug

30. Heute in Österreich, ORF 2, 5.3.2012 17:05 Uhr: Allergietest für Schulkinder

31. Zeit im Bild, ORF 2, 05.03.2012 19:30 Uhr: Mikrochip testet über 100 Allergien aus

32. Wissen aktuell; Ö1; 7.03.2012 13:55 Uhr: Warum wir gegen Schnupfen nicht immun

werden


Immunpathology

69

1.3.2. Research Awards: n = 8 1. Eckl-Dorna Julia: Hansaton Wissenschaftspreis, HNO – Österreichische Gesellschaft

für Hals- Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, September 14, 2012.

2. Gallerano Daniela: Poster Award, 3rd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 18, 2012

3. Madritsch Christian: Poster Award of the Austrian Society of Allergology and Immunology, Annual Meeting of the Austrian Society for Allergology and Immunology, Vienna, Austria, November 2012

4. Narayanan Meena: Keystone Symposia Global Health Travel Award, Bill and Melinda Gates Foundation.

5. Niespodziana Katarzyna: “AAAAI Young Investigators Award” of the American Academy of Allergy, Asthma & Immunology

6. Resch Yvonne: Travel Award of the ÖGAI for the 3rd European Congress of Immunology, Glasgow, September 5-8, 2012

7. Srinivasan Bahrani, EFIS travel grant for ECI 2012, Glasgow, September 5-8, 2012.

8. Valenta Rudolf: “Inventor of the year 2012” of the Medical University of Vienna.

1.3.3. Invited lectures: n = 15 1. Margarete Focke-Tejkl: Adjuvant 2012 & Allergen Vaccines 2012 Congress in

Varadero, Cuba on “Molecular and immunological characterization of BM32, a grass pollen allergy vaccine based on non-allergenic peptides fused to hepatitis PreS“

2. Rudolf Valenta 29th Symposium of the Collegium Internationale Allergologicum (CIA) – Allergen Specific Immunotherapy, Poster Session 10, Chairperson, October 14-19, 2012, Jeju Island, Republic of Korea.

3. Rudolf Valenta 33rd Annual Meeting of SPAIC (Portuguese Society of Allergology and Clinical Immunology) – Asthma, allergy and co-morbidities: “New approaches for immunotherapy with recombinants”, October 4-6, 2012, Fátima, Portugal

4. Rudolf Valenta 3rd European Congress of Immunology – ECI 2012: “Immunotherapeutics provide insights into pathogenesis”, September 5-8, 2012, Glasgow, Scotland

5. Rudolf Valenta Adjuvant & Allergen Vaccines 2012: “From mechanisms of allergen-specific immunotherapy towards side effect-free allergy vaccines”, May 5-11, 2012, Varadero, Cuba

6. Rudolf Valenta Allergy meeting, University of Copenhagen: “Allergens and allergen specific immune therapy”, November 28, 2012, Copenhagen, Denmark

7. Rudolf Valenta Asthma Birth Cohorts Workshop, NIH Neuroscience Center. September 11-12, 2012, Bethesda, Maryland, USA


Immunpathology

70

8. Rudolf Valenta EAACI (European Academy of Allergy and Clinical Immunology) Congress 2012: “Autoreactive IgE in Chronic allergic disease”, “Immune responses induced by immunotherapy”, “Choosing the right extract for immunotherapy”, June 16-20, 2012, Geneva, Switzerland

9. Rudolf Valenta MeDALL – Mechanisms of the Development of ALLergy. Second annual meeting: “Characterization of inhalt and food allergens”, “IgE microarrays in MeDA ”, 23-24, 2012, Paris, France

10. Rudolf Valenta Second international meeting on gluten sensitivity at the Schär Institute: “Identification and epitope characterization of a novel IgA reactive wheat antigen”, December 1-2, 2012, Munich, Germany.

11. Rudolf Valenta Seminar, Vortrag, Charité Centrum für Innere Medizin und Dermatologie, February 6, 2012, Berlin, Germany

12. Rudolf Valenta V World Asthma & COPD Forum: “Therapeutic targeting of IgE”, April 22-24, 2012, New York, USA

13. Rudolf Valenta Vortrag, Seminarreihe Immunologie, Allergologie, Pneumologie, Philipps Universität Marburg: “Towards side effect-free vaccination against allergy”, January 30, 2012, Marburg, Germany

14. Rudolf Valenta Workshop Molekulare Allergologie, Allergien besser verstehen: „Pathomechanismen der Allergie“, „Mechanismen der SIT“, August 31 - September 1, 2012, Vienna, Austria

15. Rudolf Valenta Advisory Board Meeting. MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, January 12-14, 2012, London, Great Britain




Function Intern. Congress, Name, date

Function

Rudolf Valenta Molekulare Allergologie, Phadia, 08/31/2012.-

09/01/2012,

Co-organizer

Rudolf Valenta Neues aus der Allergieforschung

Tag der offenen Tür an der

Medizinischen Universität Wien,

10.3.2012

Organizer

Rudolf Valenta SFB-Meeting, Ottenstein,

11/04/2012.-11/05/2012

Organizer


Immunpathology

71

1.3.5. Hosting speakers division member Speaker´s name Affiliation Date

Rudolf Valenta Dr. Joost van Neerven

Wageningen University Cellbiology and Immunology Wageningen, the

Netherlands

01/20/2012

Rudolf Valenta Prof. Annika Scheynius

Translational Immunology Unit, Department of Medicine

Solna,Karolinska Institutet, Stockholm Sweden

02/27/2012

Rudolf Valenta Ass. Prof. Dr. Johannes Huppa

Center for Pathophysiology, Infectiology and Immunology, Inst. for

Hygiene and Applied Immunology Immune Recognition Unit Medical

University of Vienna, Lazarettgasse 19, 1090 Vienna

02/28/2012

Rudolf Valenta Wagner Kurt Stadt Wien 02/10/2012

Rudolf Valenta Univ.Prof. Dr. Mannhalter Christine

FWF Austrian Science Fonds 02/10/2012

Rudolf Valenta Dr. Sabine Haubenwallner

FWF Austrian Science Fonds 02/10/2012

Rudolf Valenta Prof. Dr. Zsolt Szepfalusi

Uni-Klinik für Kinderheilkunde, MedUni Wien

02/10/2012

Rudolf Valenta Prof. Dr. Winfried Pickl

Institut für Immunologie, MedUni Wien

02/10/2012

Rudolf Valenta Prof. Dr. Walter Keller

Institut für Molekulare Biowissenschaften, Uni Graz

02/10/2012

Rudolf Valenta Prof. Dr. Erika Jensen-Jarolim

MedUni Wien und Messerli Forschungsinstitut der VetMed Uni

Wien

02/10/2012

Rudolf Valenta Prof. Dr. Ursula Wiedermann-

Schmidt

Institut für Spezifische Prophylaxe und Tropenmedizi, Med Uni Wien

02/10/2012

Rudolf Valenta Prof. Dr. Markus Ollert

Klinik und Poliklinik für Dermatologie und Allergologie der Technischen

Universität München

06/11/2012

Rudolf Valenta Prof. Dr. Mats Ohlin Department of Immunotechnology, Lund University, Schweden

09/26/2012

1.3.6. Mobility

Name Program University, Country

Time frame Division In Out

Bianca Tudor Praktikant-MUW student

MUW Wien 02/06/2012 - 03/09/2012

3 X

Susanne Hradetzky

PhD student Hannover, Deutschland

04/23/2012 – 05/16/2012

3 X

Susan Paketci Beobachter zur Weiterbildung

Schülerin 06/26/2012 – 07/13/2012

3 X

Nina Celesnik Praktikum, PhD-studen

Klinika Golnik 09/17/2012 – 10/05/2012

3 X

Davide Ret Praktikant 11/19/2012 – 12/10/2012

3 X

Victoria Garib Open Medical Institute

Uzbekistan/Taschkent

11/07/2012 – 03/31/2013

3 X


Immunpathology

72



Rudolf Valenta Iranian Journal of Allergy, Asthma and Immunology”

International Board Consultant



Rudolf Valenta International Archives of Allergy and Immunology

Editor in Chief

Rudolf Valenta International Archives of Allergy and Immunology

Editorial Board

Rudolf Valenta ACI International Editorial Board

Rudolf Valenta Allergo Journal Editorial Board

Rudolf Valenta Journal of Investigational Allergology & Clinical

Immunology

Editorial Board

Rudolf Valenta European Journal of Clinical Investigation

Editorial Board

Rudolf Valenta Calcium Binding Proteins Editorial Board

Rudolf Valenta International Journal of Immunorehabilitation

Editorial Board

Rudolf Valenta American Journal of Plant Sciences

Editorial Board

Rudolf Valenta Revista Alergia Mexico Editorial Board

Rudolf Valenta Clinical Reviews in Allergy and Immunology

Editorial Board



Susanne Vrtala Tiroler Wissenschaftsfonds

Susanne Vrtala The Slovenian Research Agency


Name Patent

Method for designing hypoallergenic Proteins

Europa, EP12168095 3, 2012 angemeldet

Hypoallergenic allergen derivates of Pru p 3 for

immunotherapy of IgE-mediated peach allergy

Europa, EP 11.195132.3 PCT, PCT/EP2012/076553 Anmeldedatum: 21.12.2012

Hepatitis B AC Peptide Carrier Fusion Proteins as Allergy

Vaccines

PCT, PCT/EP2012/061040, angemeldet

Hypoallergenic polypeptides for the treatment of house dust mite

allergy

PCT/EP2012/063443, Europa, 24.7.2012 angemeldet

Rhinovirus VP1-Vakzin Pharmacutical composition for

the treatment and preventioon of a rhinovirus infection

PCT, PCT/AT/2010/000416, angemeldet Japan, 2012-535540, angemeldet

USA, 13/504766, angemeldet Australien, 2010312300; angemeldet


Immunpathology

73

Kanada; 2778540, angemeldet Europa ex PCT, 10775690.0, angemeldet

Anmeldedatum: 28.06.2012

S. Aureus Allergen USA, 13/395118, angemeldet Kanada, 2773236, angemeldet

Australien, 2010294472, angemeldet Japan, 2012-528277, angemeldet

Europa ex PCT, 10754430.6 Anmeldedatum: 22.08.2012

Hypoallergenic hybrid polypeptides for the treatment of

allergy

Europa ex PCT, 10.752799.6, 2012 angemeldet Australien, 2010294248; 2012 angemeldet

USA, 13/395,596; 2012 angemeldet Kanada, 2,773,424, 2012 angemeldet

Japan, 2012-528359, 2012 angemeldet 2012-528359

Allergen-Derivat China, ZL200580041627, 2012 erteilt

Wheat allergens II International PCT. PCT/SE2012/050121, 2012-02-08 angemeldet

PHA-1783 POLYALLERGENS Japan, 2012-01-30 re-examination

PHA-1881 PHL P 6 USA, 2012-07-27 re-examination

Hepatitis B Allergen Carrier internationales Patent, Anmeldedatum: 11.06.2013, 2012 bewilligt, PCT/EP2012/061040

Hausstaubmilbenallergen Australien, Anmeldedatum: 27.04.2007, Ablauftermin: 27.04.2027, bewilligt 2012

PHL P12 China, Anmeldedatum: 02.12.2005, Ablauftermin: 02.12.2025, bewilligt 2012, (PAT) ZL200580041627

Allergen Carrier Russian Federation, Anmeldedatum: 11.06.2007, Bewilligt 2012

Allergen from house-dust mites 2005-201717, Australien, Anmeldedatum: 22.04.2005, Erteilungstag: 22.10.2012

Wheat antigens and peptides for diagnosis of wheat induced

hyposensitivity


Hypoallergenic hybrid polypeptides


Nutritional formulation comprising a cow’s milk peptide-

containing hydrolysate and/or peptides derived thereof for

tolerance induction

Indonesien; 2012 Kolumbien 2012

1.3.11. Grants

Funding agency Title of project Principal investigator

FWF-SFB Coordination project Rudolf Valenta

FWF-SFB Molecular approaches to dissect pathomechanisms of allergy.

Rudolf Valenta

Biomay Impfstoffe und Toleranzstrategien für Typ I Alllergie.

Rudolf Valenta

Phadia Utility of recombinant allergens, wheat and venom allergens.

Rudolf Valenta

Christian Doppler Forschungsgesellschaft

Therapeutic peptide vaccines for allergic asthma. Rudolf Valenta

EU-Kommission/FP7 „Health“

EU Projekt MedAll Rudolf Valenta

EU-Kommission/FP7 „Health“

EU Projekt Predicta Rudolf Valenta


Immunpathology

74

Karger Verlag Personalkosten, Sachkosten Rudolf Valenta FWF Doktoratskolleg Rudolf Valenta FWF-SFB Coordination project, „Towards prevention and

therapy of allergy“ Rudolf Valenta

FWF-SFB “Towards prophylactic vaccination of allergy” Rudolf Valenta FWF-SFB Molecular, immunological and structural

characterization of mite allergens for diagnosis, prevention and specific immunotherapy.

Susanne Vrtala

Christian Doppler Forschungsgesellschaft

Development of allergen chips. Susanne Vrtala

FWF-SFB “Strategies for diagnosis, treatment and prevention of house dust“

Susanne Vrtala

FWF Regulatory role of allergen-specific antibodies Sabine Flicker FWF-SFB Allergen specific antobodies for therapy and

prevention of allergy Sabine Flicker

European Research Grant - FP7 - Seventh Framework

Towards safe and effective immunotherapy of persistent life-threatening food allergies.

Birgit Linhart

Bundesministerium für Wissenschaft und Forschung, Eu-Zusatzfinanzierung

Towards safe and effective immunotherapy of persistent life-threatening food allergies.

Birgit Linhart

FWF Recognition of allergen epitopes in secondary IgE response.

Birgit Linhart

1.3.12. Career Developments a) Habilitations: n= 0 b) Habilitations in progress: n = 2 1. Linhart Birgit: Molekulare Allergologie (2010 – ongoing)

2. Mittermann Irene: Molekulare Allergologie, "Molecular characterisation of allergens for diagnosis and therapy". (2010 – ongoing)

c) Professorships: n= 0

1.3.13. Teaching a) Bachelor students: n = 1

1. Gutfreund Sandra: Bachelor student, (2011 – in progress), Investigation of the

function of Hfq protein by mutational analysis in E.coli

b) Diploma, MDiploma and Master students: n = 3

1. Gstöttner Antonia: Diploma student, From mechanisms of food allergy to new forms of

diagnosis and treatment (2012 – in progress)


Immunpathology

75

2. Hameter Verena: Diploma student, Expression, purification, structural and immunological characterization of a Phl p5 mosaic protein (2011 – in progress)

3. Breyer Isabella: Diploma student, Entwicklung und präklinische Evaluierung neuer Vakzine gegen Allergien, (09/07/2009 – 2012)

c) PhD, MDSci, MD students: n = 13 1. Baar Alexandra: PhD student: Characterization of wheat allergens, (2009-in progress)

2. Banerjee Srinita: PhD student: Production and evaluation of peptide vaccines for house

dust mite immunotherapy (2009-in progress)

3. Cabauatan Clarissa: PhD student: Pollen Aerobiology and Pollen-Specific Immunoglobulin-E Levels of Selected Allergic Patients in the Philippines (2011 – in progress).

4. Cornelius Carolin: PhD student: Characterization of immune responses towards Hepatitis B virus antigens and epitopes (2012 – in progress)

5. Gadermaier Elisabeth: PhD Thesis: Allergen-specific antibodies (2006-2012)

6. Gallerano Daniela: PhD student, Towards the definition of HIV-related anitbody-signatures and new immunogens for vaccine design (2009 – in progress).

7. Madritsch Christoph: PhD Thesis: Isolation of grass pollen specific IgE variable regions to study mechanisms of effector cell degranulation (2009- in progress)

8. Narayanan Meena Balakumari: PhD thesis: Mechanisms underlying secondary antibody responses (12/16/2009 – in progress).

9. Nazanin Najafi: PhD thesis: IgE dependent activation of effector cells (2012- in progress)

10. Pahr Sandra: PhD student: Characterization of wheat food allergens (2010-in progress).

11. Resch Yvonne: PhD thesis: Characterization of mite allergens (2010-in progress)

12. Srinivasan Barani: PhD thesis: Characterization of wheat allergens in celiac disease patients (2008 – in progress).

13. Wollmann Eva: PhD thesis: Immune responses in human immunodeficiency virus infected and allergic patients (2011 – in progress)

1.3.14. Exams: n = 4 Susanne Vrtala: 1 a) Oral examinations: n = 2 b) Diploma and Thesis-Examinations: n = 1

Sabine Flicker: Elisabeth Gadermaier, PhD thesis examination, 7/5/2012


Immunpathology

76

Rudolf Valenta: Elisabeth Gadermaier, PhD thesis examination, 7/5/2012 Rudolf Valenta: Andreas Farkas, PhD thesis examination, c) Exam supervising: n= 1 Susanne Vrtala: 1


Immunpathology

77

1.3.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2012

Flicker Sabine 2.00 0.50 860037 Journal Club and Progress Report

Focke-Tejkl Margarete 5.00 1.00 648026 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)

Focke-Tejkl Margarete 2.00 0.50 860037 Journal Club and Progress Report

Focke-Tejkl Margarete 10.00 2.50 648022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Focke-Tejkl Margarete 4.00 1.00 648033 Wissenschaftliches Arbeiten

Linhart Birgit 2.00 2.00 802011 Problemorientiertes Lernen - 2. Semester

Linhart Birgit 2.00 0.50 860037 Journal Club and Progress Report

Swoboda Ines 5.00 1.00 648026 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)

Swoboda Ines 10.00 2.50 648022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Swoboda Ines 4.00 1.00 648033 Wissenschaftliches Arbeiten

Valenta Rudolf 5.00 5.00 648020 Hämathologie - Ausgewählte Kapitel ausFunktioneller Pathologie

Valenta Rudolf 10.00 2.50 648022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Valenta Rudolf 2.00 2.00 648024 Journal Club und Progress Report

Valenta Rudolf 5.00 2.00 648026 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)

Valenta Rudolf 4.00 4.00 648027 Pathologie des Herz- und Kreislaufsystems - Ausgewählte Kapitel aus funktioneller Pathologie

Valenta Rudolf 4.00 1.00 648033 Wissenschaftliches Arbeiten

Valenta Rudolf 2.00 0.18 860007 Special Course: Scientific Presentation

Valenta Rudolf 2.00 0.17 860201 IAI-Journal Club

Valenta Rudolf 2.00 0.18 860202 Special Course: Basic techniques in molecular and cellular biology

Valenta Rudolf 2.00 0.13 860220 Basisvorlesung Immunologie

Valenta Rudolf 2.00 0.14 901929 IAI-Basic Seminars

Valenta Rudolf 2.00 2.00 901931 Special Course: Advanced Molecular cloning techniques

Valenta Rudolf 2.00 1.00 901941 Special Course: Allergology

Vrtala Susanne 2.00 0.50 860037 Journal Club and Progress Report

Vrtala Susanne 10.00 2.50 648022 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Vrtala Susanne 4.00 1.00 648033 Wissenschaftliches Arbeiten

Sum 36.80


Immunpathology

78

WS 2012/13

Flicker Sabine 2.00 0.50 860019 Humoral immune responses

Focke-Tejkl Margarete 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Focke-Tejkl Margarete 5.00 1.00 514034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)

Focke-Tejkl Margarete 4.00 1.00 648002 Wissenschaftliches Arbeiten

Focke-Tejkl Margarete 10.00 2.50 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Linhart Birgit 2.20 0.27 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Linhart Birgit 2.00 0.50 860019 Humoral immune responses

Marth Katharina 5.80 0.13 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Marth Katharina 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Mittermann Irene 1.13 0.53 801001 BL 1 - Gesunde und kranke Menschen

Mittermann Irene 1.00 2.00 801011 Problemorientiertes Lernen - 1. Semester

Mittermann Irene 2.00 0.50 860019 Humoral immune responses

Valenta Rudolf 5.80 0,40 803002 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Valenta Rudolf 4.00 4,00 514002 Pathologie des Herz- und Kreislaufsystems - Ausgewählte Kapitel aus funktioneller Pathologie

Valenta Rudolf 5.00 2.00 514034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)

Valenta Rudolf 2.00 0.10 562515 Molekulare Aspekte der Medizinischen Forschung (Molekulare Medizin IIa)

Valenta Rudolf 2.00 2.00 648001 Journal Club and Progress Report

Valenta Rudolf 4.00 1.00 648002 Wissenschaftliches Arbeiten

Valenta Rudolf 10.00 2.50 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Valenta Rudolf 3.00 0.40 840052 Medizinisches Propädeutikum Teil 1

Valenta Rudolf 2.00 0.18 860008 Special Course: Scientific Presentation

Valenta Rudolf 2.00 0.18 870011 Medical Propedeutics II ¿ Linking Biology and Diseases - WS 2012

Valenta Rudolf 2.00 0.13 901929 IAI-Basic Seminars

Valenta Rudolf 2.00 2.00 901931 Special Course: Advanced Molecular cloning techniques

Valenta Rudolf 2.00 0.17 902241 IAI-Journal Club

Valenta Rudolf 2.00 0.18 902920 Special Course: Basic techniques in molecular and cellular biology

Vrtala Susanne 1.13 0.27 801001 BL 1 - Gesunde und kranke Menschen

Vrtala Susanne 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester

Vrtala Susanne

5.00 1.00 514034 Molekulare Allergologie - Anleitung zum Wissenschaftlichen Arbeiten (Wahlfachausbildung gem. § 13 lit.a StG.)

Vrtala Susanne 4.00 1.00 648002 Wissenschaftliches Arbeiten


Immunpathology

79

Vrtala Susanne 10.00 2.50 648005 Immunologie - Ausgewählte Kapitel aus Funktioneller Pathologie

Sum 30.74



Medical Biotechnology

80

1.4 Division for Medical Biotechnology Head: Heimo Breiteneder, Professor

1. Publications7 IF Number Top/Std/Subst

Heimo Breiteneder 1.830 3 0 Top, 3 Std

Karin Hoffmann-S. 5.347 3 2 Top, 1 Std

Yan Ma 0.437 1 0 Top, 1 Std

Christian Radauer 0.567 1 0 Top, 1 Std

Division-Sum 7.177



2. Supervision of diploma and doctoral students Bachelor st. Diploma st. Doctoral st.

Heimo Breiteneder 2 4 Karin Hoffmann-S. 5 1 Yan Ma 4 2 Christian Radauer 1 1 Stefan Wagner 1

Sum 12 8 3. Teaching SS* WS* total W+S oral Exams

Heimo Breiteneder 3.67 5.0 8.67 0 Merima Bublin 1 0 1.00 3 Christine Hafner 0 1.00 1.00 4 Karin Hoffmann-S. 3.67 5.8 9.47 8 Yan Ma 7.89 4.02 11.91 22 Christian Radauer 0.67 1.53 2.20 0 Sum 16.9 17.35 34.25 37





81

1.4.1. Publications a) Peer-reviewed original articles: n = 6

Nr. Article IF Class pro-rata

IF

1. Alessandri, S., A. Sancho,S. Vieths, C. Mills, J. Wal, P. Shewry, N. Rigby, and K. Hoffmann-Sommergruber. 2012. High-throughput NMR Assessment of the Tertiary Structure of Food Allergens. PLoS One (7): e39785.

4.092 Top 4.092

2. Hoflehner, E., K. Hufnagl, I. Schabussova, K. Hoffmann-Sommergruber, B. Bohle and U. Wiedermann. 2012. Prevention of Birch Pollen-related Food Allergy by Mucosal Treatment with Multi-Allergen-Chimers in Mice. PlosONE 7(6): e39409

4.092 Top 0.818

3. Somkuti, J., M. Bublin, H. Breiteneder and L. Smeller. 2012. Pressure-temperature stability, Ca(2+) Binding, and pressure-temperature phase diagram of cod parvalbumin: Gad m 1. Biochemistry 51(30):5903-11

3.422 St. 0.684

4. Dietl, W., K. Trescher, P. Hohensinner, F. Nagel, Y. Ma, M. Wolfsberger, R. Plasenzotti, K. Hoffmann-Sommergruber, J. Wojta, M. Bauer, and BK. Podesser. 2012. SiNiTang – A Traditional Chinese Herbal Remedy Improves Cardiac Function Post-MI. J Clinic Experiment Cardiol 10.4172/2155-9880.S5-004.

2.184 St. 0.437

5. S. Vázquez-Cortés, I. Eguiluz Gracia, C. Radauer, H. Breiteneder, and M. Fernández-Rivas. 2012. Diagnostic performance of single and multiplex IgE testing to recombinant parvalbumins in fish allergy. Ann Allergy Asthma Immunol. 109: 362-363.

2.833 St. 0.567

6. Marazuela EG, Hajek R, Villalba M, Barber D, Breiteneder H, Rodríguez R and E. Batanero. A non-allergenic Ole e 1-like protein from birch pollen as a tool to design hypoallergenic vaccine candidates. Mol Immunol 2012;50(1-2):83-90.

2.897 St. 0.579

sum 19.52 7.177

b) Invited Articles & Reviews with IF: n = 0


sum c) Invited Articles & Reviews without IF: n = 5 1. Hoffmann-Sommergruber Karin: Papadopoulos NG, I.Agache, S. Bavbek, BM. Bilo, F. Braido, V. Cardona, A. Custovic, J. Demonchy, P. Demoly, P. Eigenmann, J. Gayraud, C. Grattan, E. Heffler, PW. Hellings, M. Jutel, E. Knol, J. Lötvall, A. Muraro, LK. Poulsen, G. Roberts, P. Schmid-Grendelmeier, C. Skevaki, M. Triggiani, R. Vanree, T. Werfel, B. Flood, S. Palkonen, R. Savli, P. Allegri, I. Annesi-Maesano, F. Annunziato, D. Antolin-Amerigo,








82

C. Apfelbacher, M. Blanca, E. Bogacka, P. Bonadonna, M. Bonini, O. Boyman, K. Brockow, P. Burney, J. Buters, I. Butiene, M. Calderon, LO. Cardell, JC Caubet, S. Celenk, E. Cichocka-Jarosz, C. Cingi, M. Couto, N. Dejong, S. Del Giacco, N. Douladiris, F. Fassio, JL. Fauquert, J. Fernandez, MF. Rivas, M. Ferrer, C. Flohr, J. Gardner, J. Genuneit, P. Gevaert, A. Groblewska, E. Hamelmann, HJ. Hoffmann, K. Hoffmann-Sommergruber, L. Hovhannisyan, V. Hox, FL. Jahnsen, O. Kalayci, AF. Kalpaklioglu, J. Kleine-Tebbe, G. Konstantinou, M. Kurowski, S. Lau, R. Lauener, A. Lauerma, K. Logan, A. Magnan, J. Makowska, H. Makrinioti, P. Mangina, F. Manole, A. Mari, A. Mazon, C. Mills, EC. Mingomataj, B. Niggemann, G. Nilsson, M. Ollert, L. , O'Mahony, S. O'Neil, G. Pala, A. Papi, G. Passalacqua, M. Perkin, O. Pfaar, C. Pitsios, S. Quirce, U. Raap, M. Raulf-Heimsoth, C. Rhyner, P. Robson-Ansley, RR. Alves, Z. Roje, C. Rondon, O. Rudzeviciene, F. Ruëff, M. Rukhadze, G. Rumi, C. Sackesen, AF. Santos, A. Santucci, C. Scharf, C. Schmidt-Weber, B. Schnyder, J. Schwarze, G. Senna, S. Sergejeva, S. Seys, A. Siracusa, I. Skypala, M. Sokolowska, F. Spertini, R. Spiewak, A. Sprikkelman, G. Sturm, I. Swoboda, I. Terreehorst, E. Toskala, C. Traidl-Hoffmann, C. Venter, B. Vlieg-Boerstra, P. Whitacker, M. Worm, P. Xepapadaki and CA. Akdis. Research Needs in Allergy Clinical and Translational Allergy. 2012. 2:21 (doi:10.1186/2045- 7022-2-21)

2. Ma Yan: Ma, Y., Food allergy prevalence: new possibilities for therapy and prevention. 2012. Med. Wochenschr.162(23-24):519-524. 3. Radauer Christian: C. Radauer, J. Kleine-Tebbe, and K. Beyer. Serie Molekulare Allergologie – Teil 8: Stabile pflanzliche Nahrungsmittelallergene: Speicherproteine. 2012. Allergo J, 21: 155-158. A. Kühn, C. Radauer, I. Swoboda, J. Kleine-Tebbe. Serie Molekulare Allergologie – Teil 7: Fischallergie: Parvalbumine und andere Allergene. 2012. Allergo J, 21: 16-18 C. Radauer. Latex-Frucht-Syndrom: Finger weg von Latex. 2012. CliniCum Pneumo, 5, 24-26,

d) Book contributions: n = 3 1. Dorsch-Häsler, C., K. Hoffmann-Sommergruber.Synthesebuch NRP59 2012 Kapitel:

3.2. Gesundheitliche Aspekte von GV-Pflanzen,mit Relevanz für die Schweiz. In: Medical Issues Related to Genetically Modified Plants of Relevance to Switzerland.vdf Hochschulverlag AG ETH Zürich 2012; doi 10.3218/3497-4

2. Hoffmann-Sommergruber, K., S. Alessandri, A.I. Sancho, S. Vieths, P. Shewry,C.

Mills. High-Throughput NMR Authentication of food allergens; 277-280. In: Translational Science: From Basic to Clinical Immunology and Allergy. Proceedings of the 28th Symposium of the Collegium Internationale Allergologicum (CIA) Pacini Editore, Pisa, IT; 2012. G. Marone, M. Triggian, A. Genoese eds.

3. Ma, Y. Warum wird in der Traditionellen Chinesischen Medizin nicht operiert? In: Kinderuni Wien, Studienbuch S91, Eigenverlag 2012 e) Abstracts, printed in periodicals: n = 9 1. Thuy-My Le*, Merima Bublin*, Heimo Breiteneder, Montserrat Fernández-Rivas,

Riccardo Asero, Barbara Ballmer-Weber, Laura Barreales, Peter Bures, Simona Belohlavkova, Frédéric de Blay, Michael Clausen, Ruta Dubakiene, David Gislason,



83

Els van Hoffen, Monika Jedrzejczak-Czechowicz, Marek L. Kowalski, Tanya Kralimarkova, Jonas Lidholm, Åsa Marknell DeWitt, Clare E.N. Mills, Nikolaos G. Papadopoulos, Todor Popov, Ashok Purohit, Ronald van Ree, Suranjith Seneviratne, Athanasios Sinaniotis, Colin Summers, Sonia Vázquez-Cortés, Stefan Vieths, Lothar Vogel, Karin Hoffmann-Sommergruber, André C. Knulst, Kiwi fruit allergy across Europe: clinical manifestation and IgE recognition patterns Conference. 31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI). Sponsor(s): European Acad Allergy & Clin Immunol (EAACI) Allergy Volume: 67 Special Issue: SI Supplement: 96 Pages: 60-61 Meeting Abstract: 125 Published: NOV 2012, Geneva, Switzerland, June 16-20, 2012.

2. Zuidmeer-Jongejan, L , Fernandez-Rivas, M, Reig, I, Barreales, L; Knulst, A, Le, T,

Purohit, A, de Blay, F, Clausen, M, Gislason, D, Dubakiene, R, Kowalski, M, Jedvzejczak-Czechowicz, M, Lidholm, J, Kralimarkova, T, Popov, T, Asero, R, Seneviratne, S, Sinaniotis, N, Papadopoulos, Bures, P, Scheurer, S, Vieths, S, Hoffmann-Sommergruber, K, van Ree, R, Ballmer-Weber, B: Component resolved diagnosis (CRD) for tomato allergy in twelve European countries (EuroPrevall study) Conference. 31st Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI). Sponsor(s): European Acad Allergy & Clin Immunol (EAACI) Source: Allergy Volume:Special Issue: SI Supplement: 96 Pages: 596-596 Meeting Abstract: 1584 Published: NOV 2012, Geneva, Switzerland. JUN 16-20, 2012.

3. Lukschal, A ., Wallmann, J., Bublin, M., Breiteneder, H., Hantusch, B., Pali-Scholl,

I., Jensen-Jarolim, Erika: A peptide mimicking an important carbohydrate epitope cross-reactive between birch proteins and celery allergen Api g 5. Immunology 2012. Volume: 137, Spp: 1: 435-436, September 5, 2012.

4. Ashjaei, K., Lengger, N., Smole, U., Bublin, M., Hoffmann-Sommergruber, K.,

Breiteneder, H. Wagner, S.: Differential T-cell responses to dendritic cells stimulated by inhalant and food allergens. Allergy Volume: 67 ; Supp: 96: 48-48. June 18, 2012.

5. Ackerbauer, D., Kostadinova, M., Bublin, M., Breiteneder, H.: Identification of a

major IgE-binding epitope of beta-parvalbumins using scFv antibodies. Immunology 2012, Volume: 137, Supp: 1: 450-450. September 05, 2012.

6. Ackerbauer, D., Kostadinova, M., Moraes, A., Bublin, M., Valente, A., Breiteneder,

H.: Production of C-13, N-15-labelled Gad m 1 for the determination of its structure and a major IgE-binding epitope. Allergy 2013, Volume: 67 ; Supp: 96: 550-550. June 16, 2012.

7. C. Radauer, A. Pomes, A. Nandy, F. Ferreira, P. Rozynek, M. Raulf-Heimsoth, R. E.Goodman, H. Breiteneder. Curation of the IUIS allergen database based on sequence similarity and protein family classification. Immunology 2012, 137 Suppl. 1: 442. Poster presentation at the 3rd European Congress of Immunology, Glasgow, United Kingdom. Sept. 5-8, 2012.

8. Gepp, B., Lengger, N., Briza, P., Wallner, M., Smole, U., Ferreira, F., Radauer, C., Breiteneder, H.,: Epitope grafting between Bet v 1 and its homologue Api g 1 produces chimeric proteins with highly different lysosomal stability. Allergy Volume: 67 ; Supp: 96: 37-38. June 16-20, 2012.

9. Guhsl, E., Hofstetter, G., Ebner, C., Hemmer, W., Breiteneder, H., Radauer, C.,: Directed in vitro evolution as a tool for the identification of conformational IgE epitopes of the major birch pollen allergen Bet v 1. Immunology 2012, Volume: 137, Supp: 1: 450-450. September 05, 2012.

http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=T2BfOh4daiJ5h36E15a&page=1&doc=4

http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=T2BfOh4daiJ5h36E15a&page=1&doc=4

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Zuidmeer-Jongejan,%20L

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Fernandez-Rivas,%20M

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Reig,%20I

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Barreales,%20L

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Knulst,%20A

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Le,%20T

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Purohit,%20A

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=de%20Blay,%20F

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Clausen,%20M

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Gislason,%20D

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Dubakiene,%20R

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Kowalski,%20M

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Lidholm,%20J

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Kralimarkova,%20T

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Popov,%20T

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Asero,%20R

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Seneviratne,%20S

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Sinaniotis,%20N

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Papadopoulos,%20N

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Bures,%20P

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Scheurer,%20S

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Vieths,%20S

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Hoffmann-Sommergruber,%20K

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=van%20Ree,%20R

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=T2BfOh4daiJ5h36E15a&field=AU&value=Ballmer-Weber,%20B

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=Z1FilgeHgIOlNjGG5F5&field=AU&value=Bublin,%20M

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=Z1FilgeHgIOlNjGG5F5&field=AU&value=Bublin,%20M

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=Z1FilgeHgIOlNjGG5F5&field=AU&value=Hantusch,%20B

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=R1DBbIAlBpl2aJI5CBI&field=AU&value=Ackerbauer,%20D&cacheurlFromRightClick=no

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=R1DBbIAlBpl2aJI5CBI&field=AU&value=Bublin,%20M

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&colName=WOS&SID=R1DBbIAlBpl2aJI5CBI&field=AU&value=Valente,%20A



84

f) Abstracts, in congress proceedings or abstract books: n = 12 1. Kazem Ashjaei, Nina Lengger, Ursula Smole, Merima Bublin, Heimo Breiteneder,

Karin Hoffmann-Sommergruber, Stefan Wagner. Specific interaction of dendritic cells in response to several allergens. 8th YSA-PHD-Symposium, Vienna, Austria, June 13-14, 2012. 63 (P12).

2. Kazem Ashjaei, Nina Lengger, Ursula Smole, Merima Bublin, Heimo Breiteneder,

Karin Hoffmann-Sommergruber, Stefan Wagner. Influence of Dendritic cells of allergic individuals stimulated with specific and unspecific allergens on autologous helper T-cells. 3rd Retreat of the center (CEPII), Vienna, Austria, September 18, 2012.

3. Sabrina Brandtner: "Pollen sampling in Vienna: Determination of Bet v 1 and Phl p 5

content in 2010 to 2011" 56. Österreichischer HNO Kongress der Österreichischen Gesellschaft für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Austria, . September 12.-15, 2012.

4. K. Hoffmann-Sommergruber “Allergen protein families – what makes them so

pe u r?” HESI-I SI Meeting “Symposium on Sensitizing Properties of Proteins” Hosted by the HESI Protein Allergenicity Technical Committee, Prague, Czech Republic, April 12, 2012. 5. K. Hoffmann-Sommergruber: “Assessing the risk of anaphylaxis in patients with

or ergy syndromes” EAACI Annual Meeting Geneva: Postgraduate Course. Geneva, Switzerland June 16, 2012.

6. K. Hoffmann-Sommergruber: Komponentendiagnostik bei Nahrungs mittelallergien. Wörtherseesymposium:, Carinthia, Austria, June 22, 2012.

7. K. Hoffmann-Sommergruber “Aut ent t on of food ergen qu ty”. „Belgrade Food Int. Conference: Food, health and well being (Nov. 26 – 28, 2012), Belgrade, Serbien, November 27, 2012. 8. Ma Yan, Peter Karoline, Liu Jianggang, Zhang Lei, Bauer Rudolf, Breiteneder Heimo, Shi Dazuo: Anti-inflammatory effects of Chinese herbal medicine on ventricular remodelling mechanisms after acute myocardial infarction. Joint Meeting of the CACMS and the Austrian TCM Platform organized by Eurasia Pacific Uninet, Vienna, Austira, August 24-28, 2012. 9. Ma Yan, Su Rui, Breiteneder Heimo, Fan Jiping: Application of the Chinese herbal medicine in the treatment of mild to moderate degrees of depressive disorder. Joint Meeting of the CACMS and the Austrian TCM Platform organized by Eurasia Pacific Uninet, Vienna, Austria. August 24-28, 2012. 10. Ma Yan, Chen Shao-liang, Mohl Werner, Maurer Gerald: Sino-Austrian Diagnosis, Treatment and Research Center of Cardiovascular Diseases. Eurasia Pacific Uninet - 4th Plenary Meeting, Shanghai, China. October 26-28, 2012. 11. Pucciarelli, D., van den Driesch, S., Wagner, S., J. Vellekoop, M., Breiteneder, H.,

Hafner, C.: A mid-infrared sensor system for detecting changes in melanoma cells treated with anti-225D9.2-TT antibodies. Young Scientist Association-PhD Symposium, Medical University of Vienna; Vienna, Austria, June 13-14, 2012.

12. Pucciarelli, D., Lengger, N., Wagner, S., Breiteneder, Heimo and Hafner, C.: Anti-

CSPG4-specific antibodies enhance the effects of the braf inhibitor PLX-4032 on



85

melanoma cells. 3rd Retreat of the Center of Pathophysiology, Infectiology and Immunology; Medical University of Vienna; Vienna, Austria Sept 18, 2012.

g) Teaching Scripts and Books, n = 67 Breiteneder Heimo ehrunterlagen (Teaching Scripts) für VO 502.362 „Nahrungsmittelallergie“ 1. Nahrungsmittelallergene: Proteinfamilien und Kreuzreaktivitäten, Teil A 2. Nahrungsmittelallergene: Proteinfamilien und Kreuzreaktivitäten, Teil B 3. Gentechnisch veränderte Nahrungsmittel und Allergie 4. Physikalisch-chemische Eigenschaften von Nahrungsmittelallergenen Lehrunterlagen (Teaching Scripts) für VO 648.401 „Ausgewählte Kapitel der medizinischen Biotechnologie“ 1. Embryonic stem cells 2. From Dolly to iPS cells 3. Animal Biopharming 1 4. Animal Biopharming 2 ehrunterlagen (Teaching Script) für „Universitätslehrgang für Grundlagen und Praxis der TCM“ 1. Zhan Zhuang Gong Lehrunterlage für Unterrichtstätigkeit im Rahmen des EU Projektes EngCaBra 1. How to write a scientific paper Bublin Merima: Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St. 1. Das mukosale I(mmunsystem) 2. IgE-vermittelte Nahrungsmittelallergie: Epidemiologie, Symptome, Diagnose, Therapie, Prävention 3. Nicht IgE-vermittelte Nahrungsmittelunverträglichkeiten 4. Methoden zur Identifizierung und Charakterisierung von Nahrungsmittelallergenen Hafner Christine: Lehrunterlagen für Unterrichtstätigkeit im Rahmen des EU Projektes EngCaBra 1. Experimental tumor therapies 2. Cell based therapies 3. Medical sampling and diagnostic methods for skin cancer Lehrunterlagen für die Vorlesung Stem Cells and Tissue Engineering 881.002 (gem. mit Cornelia Kasper und Regina Guillani) 1. Structure, organization and Control of Cells and Tissue 2. Immunology, Tolerance, Transplant Immunology 3. Introduction to Regeneration, Wound Healing, Strategies for the Reconstruction of

Specific Tissues 4. Tissue Engineering: Bioengineered skin constructs



86

Hoffmann-Sommergruber Karin: Lehrunterlagen für die Vorlesung NM-Allergien und Intoleranzen 514.074 NM Allergien und Intoleranzen (gemeinsam mit Priv. Doz. Dr. Merima Bublin) VO 2 St. 1. Einführung: Immunsystem, Grundlagen und Pathomechanismus der allergischen

Reaktion 2. NM Allergien: Symptome, Prävalenz 3. Allergene 4. Diagnostik von NM-Allergien und Fallbeispiele 5. NM-Intoxikationen, Immunmediierte NM-Allergien - Zöliakie; NM- Intoleranzen;

Fallbeispiele 6. NM Allergien: Genetische Aspekte; Umwelteinflüsse bei Allergieentstehung;

Hygienehypothese 7. Präventionsmaßnahmen: Allergenkennzeichnung 8. NM-Allergien: Therapienansätze Lehrunterlagen für die Vorlesung Ausgewählte Kapitel der medizinischen Biotechnologie 648.401 (gem. mit Priv. Doz. Wagner, Doz. Radauer, Prof. Breiteneder und Priv. Doz. Bublin) VO 2 St. 1. Vakzine und Adjuvantien 2. GM-Food 3. GM-Food and PMPs

Lehrunterlagen für die VO: Infectious Diseases and Vaccines 881.001, 2 St. (gemeinsam mit Reingard Grabherr, im Rahmen des Masterlehrganges: Medizinische Biotechnologie: (BOKU – MedUniWien): 1. Immunology 2. Molecular Biology: Isolation and detection methods 3. Bacterial Infections 4. Allergy Vaccines 5. Vaccines and Adjuvants Ma Yan: ehrunterlagen für die Vorlesungen „Akupunktur und zugehörige Therapien“ und „Chinesische Medizin in der Praxis“: 1. 891.009: M3 - Einführung in die Medizinische chinesische Fachsprache und Kultur (3) SE 0,67 St. 2. 891.013: M3 - Akupunktur-Behandlung und Moxibustion VO 2,67 St. 3. 891.015: M3 - Innere Medizin in der TCM VO 1,34 St. 4. 891.016: M3 - Experimentelle Akupunktur VO 0,67 St. 5. 891.017: M3 - Klassische Literatur der Akupunktur und Moxibustion SE 0,13 St. 6. 891.018: M3 - Klinische Observation in China oder in Österreich PR 2,67 St. 7. 891.013: M4 - Einführung in die medizinische chinesische Fachsprache und Kultur (4) SE 0,54 St. 8. 891.015: M4 - Orthopädie in der TCM VO 0,54 St. ehrunterlagen für die Vorlesungen „Tuina und Qigong Therapien“: 1. 890.048: Lebensqualität, Qualitätsmanagement, Management, Wissenschaftliches Arbeiten SE 2,17 St. 2. 891.050: M5 - Tuina und Massage VO 1,6 St. 3. 891.051: M5 - Klinische Observation oder Praktikum in China oder in Österreich PR 2,67 St. 4. 891.052: M5 - Einführung in die Medizinische chinesische Fachsprache und Kultur (5) SE 0,8 St.



87

Lehrunterlagen für die Vorlesungen: 1. 890.048: Lebensqualität, Qualitätsmanagement, Management, Wissenschaftliches Arbeiten SE 2,17 St. Radauer Christian: Lehrunterlagen für die Vorlesung Nahrungsmittelallergie 502.362, VO 2 St. 1. Molekulare und zelluläre Grundlagen der IgE-vermittelten Allergie 2. Ursachen allergischer Erkrankungen 3. Probleme in der Allergiediagnostik; Allergene und Kreuzreaktionen pflanzlicher und tierischer Nahrungsmittel 4. Allergenität verarbeiteter Nahrungsmittel; Versteckte Allergene und

Lebensmittelkennzeichnung Lehrunterlagen für die Vorlesung "Ausgewählte Kapitel der medizinischen Biotechnologie"; 648.401; VO 2 St. 1. Design von Antikörperderivaten für Diagnostik und Therapie 2. Kombinatorische Methoden zur Entwicklung neuer Wirkstoffe ehrunterlagen für die Vorlesung „Ausgewählte Kapitel der medizinischen Biotechnologie“ 648.401 VO 2 SSt. 1. Kombinatorische Methoden zur Entwicklung neuer Wirkstoffe 2. Antikörperderivate für Diagnostik und Therapie ehrunterlagen für die Vorlesung „Nahrungsmittelallergie“ 502.362 VO 2 SSt. 1. Mechanismus der IgE-vermittelten allergischen Reaktion 2. Genetische und umweltbedingte Ursachen allergischer Erkrankungen 3. Wichtige Allergenquellen und Kreuzreaktivitäten in der Nahrungsmittelallergie:

molekulare Ursachen, klinische Relevanz, Probleme in der Diagnostik 4. Allergenität verarbeiteter Nahrungsmittel ehrunterlagen für die Vorlesung „Biological Therapeutics“ 881.000 VO 2 SSt. 1. Antibody structure, function, development and production 2. Therapeutic monoclonal antibodies 3. Monvalent antibody fragments 4. Bivalent and bispecific antibody fragments 5. Antibody conjugates h) Articles in Medical Journals: n= 0 i) Public Activity: n = 2 Hoffmann-Sommergruber Karin: Zeitungsartikel: Standard; „Aug 9, 2012: „Das Immunsystem spielt verrückt!“ Ma Yan: MedUnique Magazin Ausgabe 01/2012: „Tradition und Moderne“. Zukunft S12.

1.4.2. Research Awards: n = 6 Gepp Barbara:

1. Oral Abstract Prize at the 31st Annual Congress of the European Academy of Allergy & Clinical Immunology from EAACI, June 18, 2012 Geneva, Switzerland.



88

2. Junior Poster Prize at the 31st Annual Congress of the European Academy of Allergy

& Clinical Immunology from EACCI, June 16, 2012 Geneva, Switzerland.

3. Travel grant for the 31st Annual Congress of the European Academy of Allergy and Clinical Immunology from EACCI, June 16 – 20, 2012 Geneva, Switzerland.

Guhsl Eva: 1. Travel grant for ECI Glasgow 2012 from ÖGAI, European Congress of Immunology,

Sept. 5.-8., 2012, Glasgow, UK Ma Yan:

1. Travel grant for 4th Plenary Meeting of Eurasia-Pacific Uninet - China. 2012

2. International Award for Contribution to Chinese Medicine from World Federation of Chinese Medicine Societies. China 2012

1.4.3. Invited lectures: n = 24 Breiteneder Heimo:

1. Society of Toxicology Annual Meeting: “The allergenicity and immunomodulatory effects of food substances.” San Francisco, USA. March 14, 2012

2. ImmunoDay 2012: „nsLTPs, PR10-Proteine, Profiline und Co. Grundlagen der molekularen Allergiediagnostik.“ Hannover,Germany. May 22, 2012

3. Impulse Seminar: “IgE epitope mapping with single-chain antibodies.” Dept. Pathophysiology and Allergy Research Vienna, Austria. June 01, 2012.

4. Workshop Molekulare Allergologie: “Allergene: Nomenklatur, Definition und

Datenbanken.“ Vienna, Austria. Aug 31, 2012

5. 4th EngCaBra Project Meeting: “How to write a scientific paper.” Vienna, Austria. Sept 26, 2012. Bublin Merima:

1. Österreichisches Akademisches Institut für Ernährungsmedizin: "Gentechnisch veränderte Lebensmittel", Vienna, Austria. Jan 21, 2012.

2. Pirquet-Club, IgE-Kreuzreaktivität zwischen nicht verwandten Proteinen am Beispiel der Hauptallergene der Erdnuss. organized by the Austrian Society of Allergology and Immunology. Medical University of Vienna, Austria: Dez 3, 2012.

Hafner Christine:

1. 4th EngCaBra Project Meeting: “Cell-based therapies”, Vienna, Austria. Sept 27,

2012.

2. 4th EngCaBra Project Meeting: “Course on medical sampling and diagnosis methods



89

for skin cancer”, Vienna, Austria. Sept 28, 2012.

3. 4th EngCaBra Project Meeting: “Experimental tumor therapies”, Vienna,Austria. Sept 26, 2012. Hoffmann-Sommergruber Karin:

1. HESI-I SI Meeting “Symposium on Sensitizing Properties of Proteins” Allergen protein families – what makes them so peculiar? hosted by the HESI Protein Allergenicity Technical Committee Prague, April 11 – 13, Prague, Czech Republic. April 12, 2012.

2. EAACI Annual Meeting Geneva: June 16: Postgraduate Course: “Assessing the risk of anaphylaxis in patients with oral allergy syndromes”. Geneva, Switzerland.

June 16, 2012.

3. EAACI Annual Meeting Geneva: “Recognition and uptake of food allergens” (Introductory Lecture to OAS Session, Mechanisms of Food Allergy). Geneva, Switzerland.

June 18, 2012.

4. Business Meeting Food Allergy –EAACI Geneva, “Overview of Activities of IG Food Allergy”. Geneva, Switzerland. June 17, 2012.

5. Wörtherseesymposium:“Komponentendiagnostik bei Nahrungsmittelallergien“.Velden, Austria. June 22, 2012.

6. Österreichisches Akademisches Institut für Ernährungsmedizin "Gentechnisch veränderte Lebensmittel – Nutzen oder Risiko für den Konsumenten?". Vienna, Austria. Sept 08, 2012. (im Rahmen der Fortbildung Ernährungsmedizin)

7. Belgrade Food Int. Conference: Food, health and well being: “Authentication of food allergen quality.” Belgrade, Serbien. Nov 27, 2012.

Ma Yan:

1. Kinderuni Wien 2012 „Warum wird in der Traditionellen Chinesischen Medizin nicht operiert?“ Vienna General Hospital, Medical University of Vienna, July 18, 2012.

2. Joint Meeting of the CACMS and the Austrian TCM Platform organized by Eurasia Pacific Uninet “Anti-inflammatory effects of Chinese herbal medicine on ventricular remodelling mechanisms after acute myocardial infarction” Vienna, Austria. Aug 26, 2012.

3. Joint Meeting of the CACMS and the Austrian TCM Platform organized by Eurasia Pacific Uninet “Application of the Chinese herbal medicine in the treatment of mild to moderate degrees of depressive disorder”. Vienna, Austria. Aug 27, 2012.

4. Dongfang Hospital of Beijing University of Chinese Medicine “Chinese Medicine Education in Europe”. Beijing, China. Oct 24, 2012.

5. Universitätslehrgang Interdisziplinäre Schmerzmedizin. Medical University of Vienna „Einführung in die Traditionelle Chinesische Medizin - Akupunktur, Kräutermedizin“.Vienna, Austria. Nov 27 2012.



90

6. Medical University of Vienna „ ebensqualität, Qualitätsmanagement, Management, Wissenschaftliches Arbeiten.“ Vienna, Austria. Nov 24, 2012. Christian Radauer:

1. Fortbildungsveranstaltung: “Nahrungsmittelunverträglichkeit – harmlose Kreuzreaktion oder Risiko der Anaphylaxie”? Steiermärkische Gebietskrankenkasse „Nahrungsmittelallergien – molekulare Grundlagen“. Graz, Austria. Jan 19, 2012.





Function

Breiteneder Heimo 4th EngCaBra Project

meeting and lecturing September 25-29, 2012

Organizer

Hoffmann-Sommergruber

Karin

EAACI Summer School on Food Allergy, EAACI Vienna, Austria. August

23- 25, 2012

Chair of the organising committee


Karin

EAACI Annual Meeting Geneva: Postgraduate

Course: Managing difficult issues in Food allergy, Geneva, Switzerland.

June 16, 2012

Chair of Session


Karin

EAACI Annual Meeting Geneva: Business

Meeting IG Food Allergy, Geneva , Switzerland.

June 17, 2012

Chair of Session


Karin

EAACI Annual Meeting Geneva: Junior Member Poster session, Geneva,

Switzerland. June 16, 2012

Chair of Session


Karin

EAACI Annual Meeting Geneva: Oral Abstract

Session: Mechanisms of Food Allergy, Geneva, Switzerland. June 18,

2012

Chair of Session


Karin

EAACI Annual Meeting Workshop: Quality Issues for allergenic molecules,

Geneva, Switzerland. June 18, 2012

Chair of Session



Hoffmann-Sommergruber Karin

Markus Ollert Technical University, Munich, GER July 11, 2012

Ma Yan Prof. Dr. Chang Jingling

Beijing University of Chinese Medicine

May 02, 2012



91

Ma Yan Dr. Xue Mei China Academy of Chinese Medical Sciences.

June 26, 2012

1.4.6. Mobility

Name Program University, Land Time frame Division In Out

Maria Torres, MSc Spain;

Visiting scientist Madrid Complutense University, ES

April 26 – July 26,

2012

4 X

Chang Jingling Eurasia-Pacific Uninet Scholarship Award

University of Beijing, China

Dez 1 – Feb 29, 2012

3 X

Xue Mei, Eurasia-Pacific Uninet Scholarship Award

Centre of Cardiovascular

Diseases, Xiyuan Hospital,

Academy of Chinese Medical Sciences, China

April - July 2012

4 X

Nicole Popp Laboratory internship FH Campus, Vienna

Feb 2 –March 30,

2012

4 X



Breiteneder Heimo International Union of Immunological Societies, Allergen Nomenclature

Sub-committee

Chair and Member

Breiteneder Heimo AllFam Database of Allergen Families

Member of Scientific Advisory Board

Breiteneder Heimo SDAP Structural Database of Allergenic Proteins


Bublin Merima AllFam Database of Allergen Families


Hoffmann-Sommergruber Karin European Academy of Allergy, Asthma and Clinical Immunology

Chair Interest Group Food Allergy

Hoffmann-Sommergruber Karin ÖGAI Board Member

Hoffmann-Sommergruber Karin Pirquet Club Scientific secretary

Ma Yan Consortium for Globalization of Chinese Medicine

Expert of Education Session

Ma Yan World Federation of Chinese Medicine

Member of Cardiovascular Specialist Committee

Ma Yan The World Federation of Chinese Medicine Societies

Member of Testing and Assessment Committee

Ma Yan Eurasia-Pacific Uninet Represent Member of Board of Directors

Ma Yan ASEAN-European Academic University Network

Represent Member of Board of Directors

Radauer Christian International Union of Immunological Societies, Allergen Nomenclature

Sub-committee


Radauer Christian AllFam Database of Allergen Families

Project Manager and Administrator

Radauer Christian WHO/IUIS Allergen Nomenclature Sub-Committee

Member

Radauer Christian AllFam database of allergen families Project manager



92

Wagner Stefan AllFam Database of Allergen Families




Breiteneder Heimo International Archives of Allergy and Immunology

Member of Editorial Board

Breiteneder Heimo Allergy Member of Editorial Board

Hoffmann-Sommergruber Karin International Archives of Allergy and Immunology

Member of Editorial Board



Hoffmann-Sommergruber Karin Czech Science Foundation: Grant reviewing


Name Patent

Heimo Breiteneder, Merima Bublin, Christian Radauer

Method for designing hypoallergenic proteins. EP 12168095.3, May 2012



93


FWF-SFB Molecular, immunological and structural characterization, and modifications of plant-food and latex allergens for diagnosis, prevention and specific immunotherapy.

Heimo Breiteneder

FFG Strukturelles Engineering der Hauptallergene der Erdnuss für die allergenspezifische Immuntherapie.

Heimo Breiteneder

European Community

Biomedical engineering for cancer and brain disease diagnosis and therapy development.

Heimo Breiteneder

FWF-SFB Molecular, immunological and structural characterization and modifications of plant-food and latex allergens for diagnosis, prevention and specific immunotherapy.

Heimo Breiteneder

Roche Austria GmbH

The effect of mimotope vaccine induced antibodies specific for CSPG4 and BRAF inhibitor on melanoma cells.

Heimo Breiteneder

Padia Reinigung und Charakterisierung von 5 mg des Walnussallergens Jug r 2.

Heimo Breiteneder

FWF-SFB Recombinant allergen derivatives and adjuvants to direct dendritic cells.

Heimo Breiteneder

FWF Conformational immunoglobulin E epitopes of Bet v 1. Christian Radauer

FWF-SFB Structure function relationship of food allergens. Karin Hoffmann- Sommergruber

Bundesministerium für Gesundheit, Familie und Jugend (BMGFJ) / Bundesministerium für Wissenschaft und Forschung (BMWF)

TCM and Age Related Diseases. Yan Ma

Medizinische Universität Wien

Universitätslehrgang Grundlagen und Praxis der TCM.

Yan Ma

Bundesministerium für Gesundheit, Familie und Jugend (BMGFJ) / Bundesministerium für Wissenschaft und Forschung (BMWF)

Prevention and early intervention of chronic diseases by TCM: Evaluation of immunomodulatory, anti-inflammatory and neuroprotective effects

Yan Ma

Eurasia Pacific Uninet

Evaluation of TCM Education in Vienna and Exchange Learning in China.

Yan Ma


Study on a Chinese Herbal Medicine for treating mild to moderate degrease of depressive disorder.

Yan Ma


4th Plenary Meeting of Eurasia-Pacific Uninet - China. 2012.

Yan Ma

European Community EDQM

Patienten/Konsumenten zu Anwendungen der TCM.

Yan Ma

OEAD Technologiestipendien Ost- Zentral- Südasien (Postdoc) Yan Ma



94

1.4.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0 c) Professorships: n = 0 d) Qualification Agreement: n = 3 Karin Hoffmann-Sommergruber QV- Succesfully finalised 31/5/2012, Assoc Prof. Yan Ma: Ass. Prof. 7/2012 Stefan Wagner QV- Succesfully finalised 31/5/2012, Assoc Prof.

1.4.13. Teaching a) Bachelor students: n = 0 b) Diploma, MDiploma and Master Students: n = 11 Ackerbauer Daniela: Diploma thesis. Generation of recombinant human single chain antibodies against inhalative and food allergens using phage display. (Oct 2010 – 29.05.2012). Agreiter Christiane: Diploma thesis. Purification of seed storage proteins from tree nuts and peanut and their range of cross-reactivity – implication for the nut allergic patient. (Nov 2011 – in progress). Berneder Maria: Diploma thesis. From the allergic sensitization to the effector phase: Methods to follow allergen uptake by dendritic cells, allergen characterization and evaluation of allergen chips. (Jan 2011 – in progress). Brandtner Sabrina: Master Thesis (FH, Campus Wien). Pollen sampling and Determination of Aeroallergen concentrations (Bet v 1, Phl p 5) in Ambient Air. (Nov 30, 2012). Feder Astrid: Master Thesis. Kontrollierte Prospektive Randomisierte Studie zur Effizienz der Akupunktur als perioperative Schmerztherapie bei Knietotalendoprothesen. (Nov 2012-in progress) Hinterhölzl Elisabeth: Diploma thesis. “Effects of acupuncture on chronic non-specific back pain.” (Nov 2010 – in progress).



95

Hofstetter Gerlinde: Master Thesis (FH, Campus Wien). Entwicklung eines Immunoassays zum Nachweis von Bet v 1 verwandten Allergenen in pflanzlichen Nahrungsmitteln (Oct 2012- in progress). Claudia Jelinek: Diploma thesis. Characterisation of protein pattern and allergens from sunflower (Helianthus anuus) seeds). (Dez 19, 2012). Kriehuber Michael: Diploma Thesis. The informed patient and TCM – Pretest of a TCM-Patient-Information-Text regarding Relevance, Comprehensibility and Utility. (June 2012 – in progress). Kühebacher Maria: Diploma Thesis. Reinigung und immunologische Charakterisierung des Lipid Transfer proteins Cor a 8 und komponentenspezifische Allergiediagnostik bei Haselnussallergikern (April 2011 – in progress). Marchart Kristina: Diploma thesis. Qualitative und quantitative analysis of Chinese medical herbs for the prevention and therapy of acute myocardial infarction and diabetes. (Nov 2009 – in progress). c) PhD, MDSci, MD students: n = 6 Ackerbauer Daniela: Doctoral thesis. The interaction of inhalative and ingestive allergens with cells of the innate immune system . (ab 29.05.2012). Ashjaei Kazem: PhD thesis. Influence of allergens on human dendritic and basophil cells. (April 2010 – in progress). Gepp Barbara: PhD thesis. Identification of allergenic determinants of Bet v 1 homologs using dendritic cells as read-out system. (April 2010 – in progress). Guhsl Eva: PhD thesis. Identification of conformational immunoglobulin E epitopes of the major birch pollen allergen, Bet v 1: their cross-reactivities and clinical relevance in the birch pollen-plant food syndrome. (Oct 2010 – in progress). Karoline Peter: PhD thesis. Analysis of the effective components of a Chinese herbal formula and its effects on post-infarction ventricular remodeling in rats. (Oct 2009 – in progress). Kostadinova Maria: PhD thesis. Entwicklung einer Vakzine gegen Erdnussallergie. (Nov 29, 2012). Daniela Pucciarelli: PhD thesis. Melanoma cell detection and identification in biopsies by IR spectroscopy. (July 2011 – in progress)



96

1.4.14. Exams a) Oral examinations n = 37

Bublin Merima n = 3 Christine Hafner = 4 Hoffmann-Sommergruber Karin n = 8 Ma Yan n = 22 b) Diploma and Thesis-Examinations: n = 3 Breiteneder Heimo: Daniela Ackerbauer: Diploma-Examination; Examiner: May 29, 2012 Maria Kostadinova: Thesis-Examination; Examiner: Nov 29, 2012 Bublin Merima: Maria Kostadinova. Thesis-Examination. Examiner: Nov 29, 2012 Hoffmann-Sommergruber Karin: Diplomprüfung Medizin: Janis Kinkel. Examiner: May 23, 2012 Diplomprüfung Medizin: Ferdinand Felix. Examiner: Dec 7, 2012 c) Exam supervising: n = 4 Breiteneder Heimo: SIP2 + SIP6 Saalleiter. Nov 28, 2012 Hoffmann-Sommergruber Karin: Beisitz Kommissionelle Prüfung Funkt Pathophysiologie Jan 17, 2012 Hoffmann-Sommergruber Karin:. Beisitz Kommissionelle Prüfung Funkt Pathophysiologie Jan 30, 2012 Radauer Christian: SIP5. July 2, 2012



97

1.4.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr.

SS 2012 Breiteneder Heimo 2.00 0.67 648401 Ausgewählte Kapitel der medizinische Biotechnologie

Breiteneder Heimo 2.00 2.00 514057 Dissertanten- und Diplomandenseminar: Anleitung zu Wissenschaftlichen Arbeiten

Breiteneder Heimo 1.00 1.00 514073 Neueste molekularbiologische Techniken - (Privatissimum)

Bublin Merima 2.00 1.00 514074 Nahrungsmittelallergien und -Intoleranzen

Hoffmann-Sommergruber Karin 2.00 1.00 514074 Nahrungsmittelallergien und -Intoleranzen

Hoffmann-Sommergruber Karin 2.00 2.00 648037 Journal Club und Progress Report

Hoffmann-Sommergruber Karin 2.00 0.67 648401 Ausgewählte Kapitel der medizinische Biotechnologie

Ma Yan 0.67 0.67 891.009 M3 - Einführung in die Medizinische chinesische Fachsprache und Kultur (3)

Ma Yan 2.67 2.00 891.013 M3 - Akupunktur-Behandlung und Moxibustion

Ma Yan 1.34 1.34 891.015 M3 - Innere Medizin in der TCM

Ma Yan 0.67 0.67 891.016 M3 - Experimentelle Akupunktur

Ma Yan 0.13 0.13 891.017 M3 - Klassische Literatur der Akupunktur und Moxibustion (-)

Ma Yan 2.67 2.00 891.018 M3 - Klinische Observation in China oder in Österreich

Ma Yan 0.54 0.54 891.013 M4 - Einführung in die medizinische chinesische Fachsprache und Kultur (4)

Ma Yan 0.54 0.54 891.015 M4 - Orthopädie in der TCM

Radauer Christian 2.00 0.67 648401 Ausgewählte Kapitel der medizinische Biotechnologie

Sum 16.90

WS 2012/13 Breiteneder Heimo 2.00 2.00 514057 Dissertanten- und Diplomandenseminar

Breiteneder Heimo 1.00 1.00 514073 Anleitung zum wissenschaftlichen Arbeiten

Breiteneder Heimo 2.00 2.00 648007 Journal Club and Progress Report

Hafner Christine 3.00 1.00 88.002 Stem Cells and Tissue Engineering

Hoffmann-Sommergruber Karin 2.20 0.80 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Hoffmann-Sommergruber Karin 2.00 1.00 881.001 Infectious Diseases and Vaccines

Hoffmann-Sommergruber Karin 2.00 2.00 648008 Journal Club und Progress Report

Hoffmann-Sommergruber Karin 2.00 2.00 648009 Anleitungen zu wiss. Arbeiten

Ma Yan 2.17 0.22 502.362 Lebensqualität, Qualitätsmanagement, Management, Wissenschaftliches Arbeiten

Ma Yan 1.60 1.00 891.009 M5 - Tuina und Massage

Ma Yan 2.67 2.00 891.013 M5 - Klinische Observation oder Praktikum in China oder in Österreich

Ma Yan 0.80 0.80 891.015 M5 - Einführung in die Medizinische chinesische Fachsprache und Kultur (5)



98

Radauer Christian 2.00 1.00 881.000 Biological Therapeutics

Radauer Christian 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Sum 17.35



Allergy Research

99

1.5 Division for Allergy Research Head: Barbara Bohle, Professor

1. Publications8 IF pro rata Number Top/Std/Subst

Bohle Barbara 23.596 8 5 / 3 / 0

Beatrice Jahn-Schmid 14.536 3 2 / 1 / 0

Division-Sum 23.596





Bohle Barbara 1 4 4

Beatrice Jahn-Schmid

Sum 1 4 4


Bohle Barbara 15.30 12.73 28.03 Beatrice Jahn-Schmid 2.00 5.53 7.53

Sum 17.30 18.26 35.56




Allergy Research

100

1.5.1. Publications a) Peer-reviewed original articles: n= 8 Nr. Article IF Class pro-rata IF

1. Hoflehner E, Hufnagl K, Schabussova I, Jasinska J, Hoffmann-Sommergruber K, Bohle B, Maizels RM, Wiedermann U. (2012) Prevention of Birch Pollen-Related Food Allergy by Mucosal Treatment with Multi-Allergen-Chimers in Mice. PLoS ONE 7(6): e39409. doi:10.1371/journal.pone.0039409

4.092 Top 0.818

2. Jahn-Schmid, B., Hauser M, Wopfner N, Briza P, Berger UE, Asero R, Ebner C, Ferreira F, Bohle, B.Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6.J Immunol. 2012 Feb 1;188(3):1559-67.doi: 10.4049

5.788 Top 5.788

3. Kitzmüller, C., M. Wallner, S. Deifl, S. Mutschlechner, C. Walterskirchen, G.J. Zlabinger, F. Ferreira and B. Bohle. A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T cell activation. Allergy 67:1375. doi: 10.1111/all.12016, 2012

6.271 Top 6.271

4. Knapp, B., G., Fischer, D., Van Hemelen, I. Fae, B., Maillere, C., Ebner, W., Schreiner, B. Bohle, and Jahn-Schmid B. Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background. BMC Immunol. 13:43, 2012.doi:10.1186/1471-2172-13-43

2.531 St 2.531

5. Canonica, G.W, C.E. Baena-Cagnani, E. Compalati, B. Bohle, S. Bonini, J. Bousquet, L. Cox, A.H. Fink-Wagner, S. González Díaz, L. Jacobsen, G. Passalacqua, R. Pawankar, S. Vieths, O. Yusuf, and T. Zuberbier. 100 Years of Immunotherapy: The Monaco Charter. Under the High Patronage of His Serene Highness Prince Albert II of Monaco. Int Arch Allergy Immunol., 160:346. 2012.DOI:10.1159/000343883

2.403 St 0.481

6. Calderon M.A., P. Demoly, R. Gerth van Wijk, J. Bousquet, A. Sheikh, A. Frew, G. Scadding, C. Bachert, H.J. Malling, R. Valenta, B. Bilo, A. Nieto, C. Akdis, J. Just, C. Vidal, E.M. Varga, E. Alvarez-Cuesta, B. Bohle, A. Bufe, W.G. Canonica, V. Cardona, R. Dahl, A. Didier, S.R. Durham, P. Eng, M. Fernandez-Rivas, L. Jacobsen, M. Jutel, J. Kleine-Tebbe, L. Klimek, J. Lötvall, C. Moreno, R. Mosges, A. Muraro, B. Niggemann, G. Pajno, G. Passalacqua, O. Pfaar, S. Rak, G. Senna, G. Senti, E. Valovirta, M. van Hage, J.C. Virchow, U. Wahn, and N. Papadopoulos. EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy. Clin Transl Allergy, 2:20. doi: 10.1186/2045-7022-2-20. 2012

3.360

St 0.672

7. Karle, A.C, G.J. Oostingh, S. Mutschlechner, F. Ferreira, P. Lackner, B. Bohle, G.F. Fischer, A.B. Vogt, and A. Duschl. Nitration of the Pollen Allergen Bet v 1.0101 Enhances the Presentation of Bet v 1-derived Peptides by HLA-DR on Human Dendritic Cells. Plos One, 7:e31483, 2012

4.092 Top 0.818

8. Kitzmüller, C., B. Nagl, S. Deifl, C. Walterskirchen, B. Jahn-Schmid, G. J. Zlabinger, and B. Bohle. Human blood basophils

6.217 Top 6.217


Allergy Research

101

do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. Allergy, 67:593. doi: 10.1111/j.1398-9995.2011.02764.x, 2012

sum 34.754 23.596

b) Invited Articles & Reviews with IF: n=0


1.

sum c) Invited Articles & Reviews without IF: n = 0 d) Book contributions: n = 1 1. Brinda Subbarayal, Marija Geroldinger-Simic and Barbara Bohle

Birch pollen-related food allergy: an excellent disease model to understand the relevance of immunological cross-reactivity for allergy. Allergic Diseases -Highlights in the Clinic, Mechanisms and Treatment, ISBN 978-953-51-0227-4, edited by Celso Pereira, 2012, pp. 141-164

e) Abstracts, printed in periodicals: n = 0 f) Abstracts, in congress proceedings or abstract books: n = 14 1. Bernhard Knapp, Gottfried Fischer, Dries Van Hemelen, Ingrid Fae, Bernard Maillerea,

Christof Ebner, Wolfgang Schreiner, Barbara Bohle and Beatrice Jahn-Schmid. Association of HLA-DR1 with the Allergic Response to the Major Mugwort Pollen Allergen: Molecular Background. European Congress of Immunology, Glasgow UK, 2012. Poster

2. Dries Van Hemelen, Vera Mahler, Ingrid Fae, Gottfried Fischer, Victoria Leb-Reichl,

Wilfried Pickl, Christof Ebner, Barbara Bohle and Beatrice Jahn-Schmid. Application of HLA class II peptide tetramers for the identification of peptide reactive CD4 T cells in the model of mugwort pollen allergy. ÖGAI -Symposium, IST, Klosterneuburg, Austria, 2012. Poster

3. Claudia Kitzmueller, Birgit Nagl, Stephan Deifl, Christian Walterskirchen, Beatrice

Jahn-Schmid, Gerhard-Johann Zlabinger, Barbara Bohle. Human basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1. EAACI Winter School, February 12th -15th, 2012, Aare, Sweden

4. C. Kitzmueller, M. Wallner, S. Deifl, S. Mutschlechner, G. Zlabinger, F. Ferreira, B.

Bohle. A hypoallergenic variant of the major birch pollen allergen Bet v 1 shows distinct characteristics in antigen processing and T cell activation. 3rd European Congress of Immunology, September 5th – 8th, 2012, Glasgow, Great Britain


Allergy Research

102

5. Kitzmüller C. , Wallner M. , Deifl S. , Mutschlechner S. , Walterskirchen C. , Zlabinger G. , Ferreira F. , Bohle B. A hypoallergenic variant of the major birch pollen allergen Bet v 1 shows distinct characteristics in antigen processing and T cell activation. 3rd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 18th, 2012, Vienna, Austria

6. Claudia Kitzmüller, Nora Zulehner, Anargyros Roulias, Peter Briza, Fatima Ferreira and

Barbara Bohle. Bet v 1 and homologous food allergens are very similar in their processing by antigen-presenting cells but differ in T cell reactivity. Annual Meeting of the Austrian Society for Allergology and Immunology. 30th November, 2012, Gugging, Austria

7. Christian Zwicker, Stephan Deifl, Claudia Kitzmüller, Gabriele, Gadermeier,Fatima

Ferreira and Barbara Bohle. Immunological Characterization of Glutathione-S-Transferase in Birch Pollen. 3rd Retreat of the Center for Pathophysiology, Infectiology and Immunology, September 18th, 2012, Vienna, Austria

8. Nora Zulehner, Birgit Nagl, Victoria Leb-Reichl, Christian Walterskirchen, Gerhard

Zlabinger, Winfried Pickl and Barbara Bohle. Human allergen-specific T cell clones show high heterogeneity and plasticity within the Th2 lineage. EAACI Winter School 2012, Are, Sweden

9. Nora Zulehner, Birgit Nagl, Victoria Leb-Reichl, Christian Walterskirchen, Gerhard

Zlabinger, Winfried Pickl and Barbara Bohle. Heterogeneity of allergen-specific Th2 cells in Type I allergy. European Congress of Immunology 2012, Glasgow, Scotland

10. Stephan Deifl, Claudia Kitzmüller, Gerhard Zlabinger, Peter Steinberger & Barbara

Bohle. Different TLR agonists exert diverse effects on immune cells from allergic individuals. European Congress of Immunology 2012, Glasgow, Scotland

11. D. Kollmann, C. Ebner, A. Mangold, H.J. Ankersmit, B. Bohle. The role of alpha-Gal in allergic reactions to meat 10th EAACI-GA²LEN Immunology Winter School 2012, Are, Sweden

12. D. Kollmann, C. Ebner, W. Emminger, A. Mangold, H.J. Ankersmit, B. Bohle.

Immunological reactions to the carbohydrate antigen alpha-Gal. European Congress of Immunology 2012, Glasgow, Scotland

13. D. Kollmann, C. Ebner, W. Emminger, B. Bohle. Characterization of alpha-Gal-specific

IgE, Zentrums-Retreat CePII 2012, Wien

14. D. Kollmann, M. Geroldinger-Simic, T. Kinaciyan, H. Huber, B. Bohle. Successful use of recombinant Mal d 1 and Bet v 1 for skin testing. ÖGAI-Meeting 2012, Klosterneuburg

g) Teaching Scripts and Books: n = 0 d) Articles in Medical Journals: n = 1

Bohle Barbara, “Von Birkenpollen und Äpfeln”, Medical Tribune, 44. Jahrg., Nummer 18, 02-05-2012


Allergy Research

103

i) Public activity n = 4 Bohle Barbara: „Spritze gegen Kreuzallergien“, Pharmareport: ifescience, 16-03-2012 Bohle Barbara: Portrait: „Aufsteiger BOKU – Alumni“, Boku Magazin, April 2012 Bohle Barbara: „Forscherin und Fahrradlbergerin“, Vorarlberger Nachrichten, 22.09.2012 Bohle Barbara: „Apfel gegen Birke“, Krone-Gesund, 01-2012

1.5.2. Research Awards: n = 2 1. Stephan Deifl, travel award of the Austrian Society for Allergology and Immunology

(ÖGAI) to attend the ECI congress 2012, Glasgow, UK

2. Dagmar Kollmann, Reisestipendium der ÖGAI für den ECI 2012 in Glasgow, Scotland

1.5.3. Invited lectures: n = 3 1. Bohle Barbara, DGAKI Allegie Workshop, "Allergen-spezifische Immunmechanismen

der Nahrungsmittelallergie", MAINZ, D, 2012-03-22 bis 2012-03-23

2. Bohle Barbara, Bencard Allergiesymposium, „Adjuvantien in der SIT bzw. welche

Bedeutung haben sie für die Zukunft“, Wien, 2012-10-20 3. Bohle Barbara, Allergy, Universität Kopenhagen, „Regulation of type 1 allergy by the

immune system“, Kopenhagen, 2012-11-30





Function

Bohle Barbara EAACI Winterschool 27. - 30. 01. 2013

Local organiser

1.5.5. Hosting speakers division member Speaker´s name Affiliation Date

1.5.6. Mobility

Name Program University, Land Time frame Division In Out

Dries van Hemelen

PhD University Medical Center Groningen,

Netherlands

06/2011 - 05/2013

6 X

Ana Sancho PhD Universität Salzburg 30/07/2012 –

15/10/2012

6 X


Allergy Research

104



Bohle Barbara Paul Ehrlich Institut, Langen, D Scientific advisor



Bohle Barbara International Archives of Allergy and Immunology

Managing Editor

Bohle Barbara Clinical and Experimental Allergy

Editorial Board Member

Bohle Barbara Immunotherapy Editorial Board Member



Bohle Barbara NIAID Clinical Trial Implementation , Cooperative Agreements, 2012-05-01

Bohle Barbara Helmholz, Post Doc Doktoranden Programm,2012-09

Bohle Barbara PhD Thesis of Martina Gattringer, "Prevention of IgE-mediated allergy by molecular chimerism and costimulation blockade in a

murine model"

Bohle Barbara PhD Thesis of Adriana De Sousa, “Mapping Innate Immunity pathways: from nucleic-acid recognition

to kinase wiring”

Bohle Barbara Diss. Gutachten, Dr. Hoetzenecker Konrad, “The secretome of mononucleat cells as a therapeutic tool in myocardial infarction and

myocarditis: an experimental study”


Name Patent


Allergy Research

105


FWF-SFB The role of cell – mediated immunity in Type I food allergies.

Barbara Bohle

Christian Doppler Gesellschaft und Biomay

Immunmodulation allergischer Erkrankungen.

Barbara Bohle

FWF Doktoratskolleg

Inflammation and Immunity.

Barbara Bohle

FWF Therapy of birch pollen- related food allergy. Barbara Bohle

FWF-SFB The Immunological basis of clinical tolerance to allergens. Barbara Bohle

FWF Strukturelle Merkmale und Immunogenität von Allergieimpfstoffen.

Barbara Bohle

1.5.12. Career Developments a) Habilitations: n = 0 b) Habilitations in progress: n = 0 c) Professorships: n = 0

1.5.13. Teaching a) Bachelor students: n =1 1. Martin Kastner: Bachelor student, 2012 – in progress, Allergenexpression in Hefe d) PhD, MDSci, MD students: n =4

1. Dagmar Kollmann: PhD Thesis: The role of alpha-Gal in allergic reactions to meet. (2011 – in progress)

2. Stephan Deifl: Doctoral Thesis: Development of allergy vaccines using Toll-like receptor ligands as immunomodulatory component (2009 in progress)

3. Brinda Subbarayal: Doctoral Thesis, Characterisation of allergen specific IgG4

antibodies (2008 - in progress)

4. Nora Zulehner: PhD Thesis: Characterization of different phenotypes of allergenspecific Th2 cells (2011 - in progress)

1.5.14. Exams a) Oral examinations: n = 0 b) Diploma and Thesis-Examinations: n = 13


Allergy Research

106

Barbara Bohle: Diploma thesis examination of Margit Scharitzer

Barbara Bohle: Diploma thesis examination of Patrik Dolliana

Barbara Bohle: Diploma thesis examination of Daniela Altenriederer

Barbara Bohle: Diploma thesis examination of Lucian Beer

Barbara Bohle: Diploma thesis examination of Mario Reis

Barbara Bohle: Diploma thesis examination of Thomas Haider

Barbara Bohle: Diploma thesis examination of Christian Walterskirchen

Barbara Bohle: Diploma thesis examination of Markus Öllinger

Barbara Bohle: Diploma thesis examination of Thubian Nabhan Abduljabbar

Barbara Bohle: Diploma thesis examination of Anna Friederike Megerle

Barbara Bohle: PhD thesis examination of Adriana Alexandra De Sousa

Barbara Bohle: PhD thesis examination of Martina Gattringer

Beatrice Jahn Schmid: Diploma thesis examination of Christian Walterskirchen c) Exam supervising: n = 1

Beatrice Jahn-Schmid: SIP 3, 27-09-2012


Allergy Research

107

1.5.15. Lectures, Seminars, Lab courses SWST pro-rata LV Nr. SS 2012

Bohle Barbara 1.00 1.00 809061 MS: Methoden der Allergologie

Bohle Barbara 4.00 2.00 648000 Anleitung zum wissenschaftlichen Arbeiten

Bohle Barbara 2.00 2.00 648035 Journal Club und Progress Report

Bohle Barbara 2.00 2.00 648036 Dissertantenseminar Ziele und Methoden der Allergologie

Bohle Barbara 4.00 0.50 808004 SSM 3-Projektstudie (Wahlpflichtteil)

Bohle Barbara 2.00 0.18 860007 Special Course: Scientific Presentation

Bohle Barbara 2.00 2.00 860101 Special Course: Cellular allergology

Bohle Barbara 2.00 0.17 860201 IAI-Journal Club

Bohle Barbara 2.00 0.18 860202 Special Course: Basic techniques in molecular and cellular biology

Bohle Barbara 2.00 0.13 860220 Basisvorlesung Immunologie

Bohle Barbara 2.00 0.14 901929 IAI-Basic Seminars

Bohle Barbara 2.00 1.00 901941 Special Course: Allergology

Bohle Barbara 2.00 2.00 902211 Dissertantenseminar: Ziele und Methoden der Allergologie

Bohle Barbara 2.00 2.00 902696 Journal Club and Progress Report

Jahn-Schmid Beatrice 4.00 2.00 648000 Anleitung zum wissenschaftlichen Arbeiten

Sum 17.30

WS 2012/13


Bohle Barbara 2.00 1.00 648006 Dissertantenseminar Ziele und Methoder der Allergologie

Bohle Barbara 4.00 2.00 648100 Anleitung zum wissenschaftlichen Arbeiten

Bohle Barbara 2.00 0.18 860008 Special Course: Scientific Presentation

Bohle Barbara 2.00 0.13 901929 IAI-Basic Seminars

Bohle Barbara 2.00 2.00 901933 Special Course: Cellular allergology

Bohle Barbara 2.00 2.00 902211 Dissertantenseminar: Ziele und Methoden der Allergologie

Bohle Barbara 2.00 0.17 902241 IAI-Journal Club


Bohle Barbara 2.00 0.18 902920 Special Course: Basic techniques in molecular and cellular biology

Jahn-Schmid Beatrice 2.20 0.53 803003 BL 8 - Krankheit, Krankheitsursachen und Krankheitsbilder

Jahn-Schmid Beatrice 2.00 1.00 648000 Journal Club und Progress Report


Allergy Research

108

Jahn-Schmid Beatrice 2.00 1.00 648006 Dissertantenseminar Ziele und Methoder der Allergologie

Jahn-Schmid Beatrice 4.00 2.00 648100 Anleitung zum wissenschaftlichen Arbeiten

Jahn-Schmid Beatrice 1.00 1.00 902542 Grundlagen der Allergologie

Kitzmüller Claudia 1.00 1.00 801011 Problemorientiertes Lernen - 1. Semester

Kitzmüller Claudia 1.13 1.07 801001 BL 1 - Gesunde und kranke Menschen

Sum 18.26



Social Events

109

IPA social events 2012

Antrittsvorlesungen Barbara Bohle und Heimo Breiteneder


Social Events

110

Weihnachtsfeier des IPA 2012 im Jugendstilhörsaal und danach im SOHO


Social Events

111


Social Events

112

Performance Report 2012 - MedUni Wien · Performance Report 2012 Department of Pathophysiology &...

Documents

Transcript of Performance Report 2012 - MedUni Wien · Performance Report 2012 Department of Pathophysiology &...