Percutaneous Mechanical (Aspirative) Thrombectomy on ... · Percutaneous Mechanical (Aspirative)...
Transcript of Percutaneous Mechanical (Aspirative) Thrombectomy on ... · Percutaneous Mechanical (Aspirative)...
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Percutaneous Mechanical (Aspirative)
Thrombectomy on Vascular Urgencies
LUIZ ANTONIO FURUYA
EQUIPE SÃO PAULO – CIRURGIA VASCULAR E ENDOVASCULAR
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Disclosure
Speaker name:
LUIZ ANTONIO FURUYA
I have the following potential conflicts of interest to report:
Consulting
Employment in industry
Stockholder of a healthcare company
Owner of a healthcare company
Other(s)
I do not have any potential conflict of interestX
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Mechanical Aspirative Thrombectomy:
Iatrogenic Bleeding
Surgery Trauma
Surgery Time
Morbimortality
Immediate
thrombus removal
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ASPIREX S / ROTAREX S
MECHANICAL THROMBUS REMOVAL DEVICES THROUGH A STRONG
NEGATIVE PRESSURE DUE TO A HIGH SPEED ROTATING HELIX.
NEW “S” DEVICES WITH BETTER NAVEGABILITY AND SUCTION POWER
ROTAREX S ATHERECTOMY
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ASPIREX S / ROTAREX S
Target vessel diameter: 3 - 5 mm Cateter 6F
Target vessel diameter: 5 - 8 mm Cateter 8F
Target vessel diameter: 8-10 mm Cateter 10F
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ASPIREX S / ROTAREX S
INDICATIONS
- ACUTE ILIOFEMORAL DEEP VEIN
THROMBOSIS
- MASSIVE PULMONARY
THROMBOEMBOLISM
- ACUTE ARTERIAL OCCLUSION
- POPLITEAL ARTERY ANEURISM (“OFF
LABEL”)
- DIALYSIS ACCESS ACUTE OCCLUSION
- CHRONICAL ARTERIAL OCCLUSION
“ Mechanical debulking“
EMBOLISM
THROMBOSIS
BYPASS GRAFT OCCLUSION
STENT GRAFT OCCLUSION
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Acute Iliofemoral Deep Vein Thrombosis
• Post thrombotic syndrome 30-60%
• Pulmonary thromboembolism 50%
• 2-4 x > risk of recurrence (3 months) *
* Pharmacomechanical Thrombectomy for iliofemoral deep vein
thrombosis Cochrane Vascular Group Feb 2015 Protocol
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Systematic Review
• Intervention Review
• Thrombolysis for acute deep vein thrombosis
• Lorna Watson1, Cathryn Broderick2, Matthew P Armon3
• 1Cameron House, Leven, UK. 2Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.
• Editorial group: Cochrane Peripheral Vascular Diseases Group.
• Publication status and date: New search for studies and content updated (no change to conclusions), published in Issue 1, 2014.
• Review content assessed as up-to-date: 4 April 2013.
Thrombolysis X Anticoagulation
1103 patients / 17 RCTs
< PTS
RR 0,64 ( 0,52-0,79) P<0,0001 95%
> Complete thrombus removal ( lisis )
RR 4,91 (1,66-14,53) P=0,004 95%
Bleeding
10% thrombolysis x 8% anticoagulation
Iliofemoral DVT Aspirative ThrombectomyScientific Evidence
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Guidelines SVS- American Venous Forum 2012
Early thrombus removal strategies for acute
deep venous thrombosis:
Clinical Practice Guidelines of the Society
for Vascular Surgery and the American
Venous Forum
J Vasc Surg 2012; 55:1449-62
Early thrombus removal in patients with good functional status and DVT <14 days GRADE 2C
Thrombus removal in patients with limb-threatening due to iliofemoral venous outflow obstruction GRADE 1A
Low Quality Studies
Iliofemoral DVT Aspirative ThrombectomyScientific Evidence
ConclusionsMost data regarding early thrombus removal strategies are of low quality but do suggest patient-important benefits with respect to reducing postthrombotic morbidity. We anticipate revision of these guidelines as additional evidence becomes available
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• Catheter-directed Thrombolysis x Pharmacomechanical Thrombectomy
• Secondary Ischemia due to phlegmasiacerulea IC
• Clinical worsening besides anticoagulationIIa C
• First choice to lower risk bleeding patients toprevent PTS IIa B
• Non-indicated > 21 dias or higher riskbleeding III B
• Systemic fibrinolysis must not be usedroutinely III ACirculation 2011; 123:1788-1830
Iliofemoral DVT Aspirative ThrombectomyScientific Evidence
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Consider venous thrombectomy:
- Symptoms for < 7 days
- Life Expectancy > 1 year
- Resources and expertise are available
- Catheter-direct thrombolysis > Open surgery thrombectomy
Antithrombotic Therapy for VTE Disease 2012
Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical
Practice Guidelines
Clive Kearon, MD, PhD, Elie A. Akl, MD, MPH, PhD, Anthony J. Comerota, MD, Paolo Prandoni, MD, PhD, Henri Bounameaux, MD, Samuel Z. Goldhaber,
MD, FCCP, Michael E. Nelson, MD, FCCP, Philip S. Wells, MD, Michael K. Gould, MD, FCCP, Francesco Dentali, MD, Mark Crowther, MD, and Susan R.
Kahn, MD
Aspirative Thrombectomy – Iliofemoral DVTScientific Evidence
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Iliofemoral DVT Aspirative ThrombectomySystematic Review
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Iliofemoral DVT Aspirative ThrombectomySystematic Review
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Acute Iliofemoral Deep Vein Thrombosis -Aspirative Thrombectomy
• Phlegmasia Cerulea Dolens – Ischemia
• Symptoms < 14 days
• Clinical worsening besidesanticoagulation
• Patients with good life expectancy
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INDICATIONS:
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APPROACH:
• US-Guided Punction
• Always beginning with inferior vena cava filter implant
• Introducer ( Sheath ) must be at least 1FR larger than thedevices to be used
• Continuous pressurized saline infusion
• Systemic heparinization + local heparinization
• Aspirex®10 F ( if possible, or 8F and then 10F )
COMUM FEMORAL VEIN
GREAT SAPHENOUS VEIN
POPLITEAL VEIN
SMALL SAPHENOUS VEIN
RIGHT INTERNAL JUGULAR VEIN
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Complications
• Venous Perforation
• Pulmonary Thromboembolism
• DVT worsening
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ACUTE LEFT ILIOFEMORAL DEEP VEIN THROMBOSIS
M.J.M.L, 43 y.o., FEMALE, PAIN AND ABRUPT LEFT LOWER EXTREMITY EDEMA. USG: COMUM ILIAC VEIN AND PROXIMAL EXTERNAL ILIAC VEIN OCCLUDED.
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ACUTE LEFT ILIOFEMORAL DVT
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ACUTE LEFT ILIOFEMORAL DEEP VEIN THROMBOSIS
A.M.C, 27 y.o, FEMALE, PRESENTING WITH PHLEGMASIA ALBA DOLENS. USG: LEFT ILIOFEMORAL OCCLUSION
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ACUTE LEFT ILIOFEMORAL DVT
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ACUTE LEFT ILIOFEMORAL DVT
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ACUTE LEFT ILIOFEMORAL DVT
M.J.P.F, 57 y.o., SEVERE LEFT LOWER EXTREMITY EDEMA ,INCREASING WITH HEPARIN SUSPENSION
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ACUTE LEFT ILIOFEMORAL DVT
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ACUTE LEFT ILIOFEMORAL DVT
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D.O.M.S, 34 y.o., 10 DAYS SEVERE LEFT LOWER EXTREMITY EDEMA
ACUTE LEFT ILIOFEMORAL DVT
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ACUTE LEFT ILIOFEMORAL DVT
D.O.M.S, 34 y.o., 10 DAYS SEVERE LEFT LOWER EXTREMITY EDEMA
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ACUTE LEFT ILIOFEMORAL DVTM.C.O.T, 40 y.o, SUDDEN LEFT LOWER EXTREMITY EDEMA AFTER 10 DAYS ANKLE IMOBILIZATION DUE TO A FRACTURE
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ACUTE LEFT ILIOFEMORAL DVTM.C.O.T, 40 y.o, SUDDEN LEFT LOWER EXTREMITY EDEMA AFTER 10 DAYS ANKLE IMOBILIZATION DUE TO A FRACTURE
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In Conclusion
• Mechanical Aspirative Thrombectomy is usefull in iliofemoral DVT’s treatment
• Technological innovation – still need more qualityscientific evidences
• Main goals – morbimortality reduction / earlyrevascularization
• Expertise and resources must be available
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Percutaneous Mechanical (Aspirative)
Thrombectomy on Vascular Urgencies
LUIZ ANTONIO FURUYA
EQUIPE SÃO PAULO – CIRURGIA VASCULAR E ENDOVASCULAR