PEPTAMEN®

Designed for Absorption and Tolerance

Enteral feeding success is dependent on a formula being absorbed and well-tolerated.

REDUCED HOSPITAL AND ICU MORTALITY RATES5

% OF

PATI

ENTS

HOSPITAL MORTALITY

43.9

ICU MORTALITY

22.5

50

45

40

35

30

25

20

15

10

5

0

33.828.3

Late

EN

Early

EN

Late

EN

Early

EN

P<.001

P=.03

A multi-institutional retrospective analysis of 1,174 hemodynamically unstable mechanically ventilated ICU patients were divided into two groups: Early EN (< 48 hrs after mechanically ventilated) or late EN. Hospital and ICU Mortality Rates were significantly reduced in the early EN group.

DECREASED LENGTH-OF-STAY3,4 Providing enteral nutrition earlier has been shown to reduce length of ICU and hospital stays.

2.2 fewer days in

hospital3

IMPROVE NUTRITION INTAKE FOR BETTER OUTCOMES1

INCREASED VENTILATOR-FREE DAYS2 Higher protein and calorie delivery

in the ICU has been shown to significantly increase ventilator-free days.

2.3 fewer days in

ICU4

Extra 30g protein per day =

Extra 1,000 kcal per day =

2.81 DAYS2

1.92 DAYS2

1. Wei X, et al. CCM 2015: DOI 10.1097/CCM. 2. Elke G, et al. Crit Care 2014; 18:R29. 3. Marik P, Zaloga G. CCM 2001; 29:2264-2270. 4. Doig G, et al. Clinico Econ and Outcomes 2013; 5:429-436. 5. Khalid I, et al. AJCC 2010; 19:261-268.

References: 1. Wei X, et al. CCM 2015: DOI 10.1097/CCM. 2. Elke G, et al. CRIT CARE 2014, 18:R29. 3. Marik P, Zaloga G. CCM 2001;29:2264-2270. 4. Doig G, et al. CLINICO ECON AND OUTCOMES 2013;5;429-436. 5. Khalid I, et al. AJCC 2010; 19:261-268.

Enteral feeding success is dependent on a formula being absorbed and well-tolerated.

PEPTAMEN® IS PROVEN TO REDUCE LOS AND ICU COSTS

1. Tiengou LE, et al. JPEN 2006;30:1-5. 2. Louie BE, et al. Can J Surg 2005;48:298-306. 3. Donald P, et al. Nutr Res 1994;14:3-13. 4. Dylewski ML et al. Nutrition Poster 72; A.S.P.E.N. Clinical Nutrition Week 2006. 5. Solomon SB, et al. J AM Diet Assoc 1998;98:460-2. 6. Fried MD, et al. J of Peds 1992;120:569-72. 7. Aguilar-Nascimento JE, et al. Nutrition 2011;27:440-444. 8. Ruppin DC, et al. Drugs 1989;20:216-224.

PEPTAMEN® INTENSE VHPHighest percentage of calories from protein (37%) of any complete feeding formula.

Lower carbohydrate level than Vital® High Protein to support the nutritional management of blood glucose in the ICU.

REDUCED COST OF NUTRITIONAL THERAPY2

Day

s

Standard FormulaP=0.006

PEPTAMEN®

30

25

20

15

10

5

0

-4 Days

Cost

per

Pa�

ent (

$)

Parenteral FormulaP=0.08

PEPTAMEN®

3000

2500

2000

1500

1000

500

0

-$1,233

A randomized, prospective study in 30 acute pancreatitis patients requiring enteral nutrition. Patients received Peptamen or an isocaloric, isonitroge-

nous, and isovolumic standard enteral nutrition solution.

A randomized, controlled study in 28 acute pancreatitis patients selected to receive either Peptamen or parenteral nutrition. Both groups were provided

25 kcal/kg/day and 1.5 g/kg/day of protein until they could tolerate a regular diet.

Enzymatically hydrolyzed

protein to provide easy-to-absorb

peptides2-6

100% whey peptides to support anabolism

and protection against oxidative stress3,7

High proportion of MCT to facilitate

fat absorption and spare nitrogen

for anabolism8

REDUCED LENGTH OF HOSPITAL STAY1

2.2 fewer days in

hospital

2.3 fewer days in

ICU

GI dysfunction and intolerance can compromise patients’ comfort and outcomes, and result in calorie or protein malnutrition.

A COMPROMISED GUT CAN CAUSE POOR OUTCOMES

Adequate nutrient provision is dependent on a formula being absorbed and well-tolerated.1. Rombeau JL, Takala J. Intensive Care Med 1997;23:476-9. 2. Landzinski J et al. JPEN 2008;32:45-50. 3. Mentec H et al. Crit Care Med 2001;29:1955-1961. 4. Gungabissoon et al. JPEN 2015;39(4):441-448.

References: 1. Wei X, et al. CCM 2015: DOI 10.1097/CCM. 2. Elke G, et al. CRIT CARE 2014, 18:R29. 3. Marik P, Zaloga G. CCM 2001;29:2264-2270. 4. Doig G, et al. CLINICO ECON AND OUTCOMES 2013;5;429-436. 5. Khalid I, et al. AJCC 2010; 19:261-268.

PEPTAMEN® CAN REDUCE SIDE EFFECTS OF INTOLERANCE

REDUCED INCIDENCES OF DIARRHEA4

A retrospective study in 17 pediatric burn patients requiring enteral nutrition. Patients received either Peptamen (n=9) or an intact casein-based formula (n=8).

IMPROVEMENT IN WEIGHT LOSS1

Wei

ght (

kg)

Standard Formula

P=0.01

PEPTAMEN®0

-0.5

-1

-1.5

-2

-2.5

-3

-1.1 kg

# of

Epi

sode

s of D

iarr

hea

Standard FormulaP=0.03

PEPTAMEN®

4

3.5

3

2.5

2

1.5

1

0.5

0

2.6

0.67

60 25

Adequate nutrient provision is dependent on a formula being absorbed and well-tolerated.

Enzymatically hydrolyzed

protein to provide easy-to-absorb

peptides2-6

100% whey peptides to help

facilitate gastric emptying6

High proportion

of MCT to decrease potential

for fat malabsorption7

PEPTAMEN® has the proof with more than clinical studies and years of experience.

A randomized, prospective study in 30 acute pancreatitis patients requiring enteral nutrition. Patients received Peptamen or an isocaloric, isonitrogenous,

and isovolumic standard enteral nutrition solution.

1. Tiengou LE, et al. JPEN 2006;30:1-5. 2. Louie BE, et al. Can J Surg 2005;48:298-306. 3. Donald P, et al. Nutr Res 1994;14:3-13. 4. Dylewski ML et al. Nutrition Poster 72; A.S.P.E.N. Clinical Nutrition Week 2006. 5. Solomon SB, et al. J AM Diet Assoc 1998;98:460-2. 6. Fried MD, et al. J of Peds 1992;120:569-72. 7. Ruppin DC, et al. Drugs 1989;20:216-224.

“Frankly, when they raced Alec into my ICU, nutrition concerns were

probably the last thing on my mind.”

• Contains high levels of branched-chain amino acids to support muscle synthesis for tissue growth and repair1

• A rich source of cysteine, a precursor to glutathione, to protect against oxidative stress and tissue damage2,3

• Helps to facilitate gastric emptying4

100% Whey Protein to Promote Tolerance and Anabolism

PEPTAMEN®

Designed for Absorption & Tolerance

PEPTAMEN® formulas are designed for absorption and tolerance with smaller, easy-to-absorb peptides.

High proportion of MCT to facilitate fat absorption

More Easy-to-Absorb Peptides

• 50-70% of fat as Medium Chain Triglycerides (MCT)

• Directly absorbed into portal circulation to help provide readily available energy5

Smaller peptides, especially di- and tri-peptides are more readily absorbed than free amino acids or larger peptides.6-10

Peptamen formulas have a greater percentage of smaller peptides compared to Vital® formulas.

% O

F PR

OTE

IN B

Y W

EIG

HT

PROTEIN MOLECULAR WEIGHT (Da)

<1000 1000 – 5000 >5000

37%33.6%

60

50

40

30

20

10

0

53%

28.3%

10%

38.1%

SmallerPeptides

LargerPeptides

PEPTAMEN®*VITAL®†

*Nestlé Health Science data on file reflecting the average peptide length and percent by weight of the Peptamen® family of formulas based on multiple batch testing of Peptamen Intense VHP®. † Vital High Protein, Abbott Vital® Family Monograph. Vital is a registed trademark of Abbott Laboratories. 1. Ha E, Zemel MB. J Nutr Biochem 2003;14:251-258. 2. Rowe B et al. J Am Coll Nutr 1994;3:535A. 3. Aguilar-Nascimento JE et al. Nutrition 2011;27:440-444. 4. Fried MD, et al. J of Peds 1992;120:569-72. 5. Ruppin DC, et al. Drugs 1989;20:216-224. 6. Grimble GK et al. Clin Nutr 1994;13(suppl):42. 7. Raybould HE. J Physiol Biochem 2008;64:349-356. 8. Grimble GK. Ann Rev Nutr 1994;14:419-447. 9. Borlase BC et al. Surg, Gynecology and Obstetrics 1992;174:181-188. 10. Tiengou LE, et al. JPEN 2006;30:1-5.

Designed for Absorption & Tolerance

The PEPTAMEN® family provides a variety of nutritional solutions for your patients with GI dysfunction:

NOW**PEPTAMEN® 1.5 with PREBIO1™

PEPTAMEN® with PREBIO1™

PEPTAMEN AF® PEPTAMEN® INTENSE VHP

PEPTAMEN® 1.5 PEPTAMEN®

**Formerly known as Peptamen® Bariatric

PEPTAMEN® formula is the only enzymatically hydrolyzed 100% whey formula designed for absorption and tolerance.

(per 1000 mL)PEPTAMEN® PEPTAMEN®

with PREBIO1™

PEPTAMEN® 1.5 PEPTAMEN®1.5 with

PREBIO1™

PEPTAMEN AF® PEPTAMEN® INTENSE VHP

Calories kcal 1000 1000 1500 1500 1200 1000

Total Fat g 40* 408 56** 56** 54* 38‡

Sodium mg 480 480 880 880 720 680

Potassium mg 1600 1600 2080 2080 1800 1500

Total Carbohydrate g 128 128 188 192 112 76

Dietary Fiber g — 4 — 6.4 6 4

Protein g 40 40 68 68 76 92

Vitamin A Retinol Beta-Carotene

mcg mcg

8001000

8001000

12001500

12001500

10001200

8001000

Vitamin C mg 120 120 180 180 140 120

Calcium mg 800 800 1000 1000 800 680

Iron mg 16 16 24 24 20 16

Vitamin D mcg 13.2 13.2 20 20 16 13.2

Vitamin E mg 20 20 30 30 32 20

Vitamin K mcg 80 80 120 120 100 80

Thiamin mg 2.4 2.4 3.2 3.2 2.8 2.4

Riboflavin mg 2.0 2.0 3.2 3.2 2.4 2.0

Niacin mg 22 22 33.2 33.2 26.4 22

Vitamin B6 mg 2.4 2.4 3.6 3.6 2.8 2.4

Folic Acid mcg 200 200 300 300 240 200

Vitamin B12

mcg 8 8 12 12 12 8

Biotin mcg 32 32 48 48 40 32

Pantothenic Acid mg 4.8 4.8 7.2 7.2 6 4.8

Phosphorus mg 700 700 1000 1000 800 680

Iodine mcg 140 140 200 200 180 140

Magnesium mg 300 300 420 420 340 300

Zinc mg 14 14 22 22 17.6 14

Selenium mcg 72 72 100 100 80 80

Copper mg 2 2 3.2 3.2 2.4 2

Manganese mg 2.8 2.8 4.4 4.4 3.2 2.8

Chromium mcg 48 48 72 72 60 60

Molybdenum mcg 100 100 160 160 180 160

Chloride mg 1000 1000 1760 1760 1360 1120

Choline mg 480 480 720 720 560 480

L-Carnitine mg 100 100 160 160 120 100

Taurine mg 100 100 160 160 120 100

*MCT provides 28 g per 1000 mL. **MCT provides 40 g per 1000 mL. ‡MCT provides 18 g per 1000 mL

PRODUCT CODE UPC (GTIN) NDC FORMAT NUMBER PACKAGING

PEPTAMEN® 1.5 UNFLAVORED

9871618192 0-07-98716-18192-1 98716-0081-9224 x 250 mL cartons/case

PEPTAMEN® 1.5 VANILLA

9871618190 0-07-98716-18190-7 98716-0081-9024 x 250 mL cartons/case

PEPTAMEN® 1.5 ULTRAPAK®

9871628194 1-07-98716-28194-9 98716-0181-946 x 1000 mL bags/case

PRODUCT CODE UPC (GTIN) NDC FORMAT NUMBER PACKAGING

PEPTAMEN®UNFLAVORED 9871616269 0-07-98716-16269-2 98716-0062-69

24 x 250 mL cartons/case

PEPTAMEN® 1.5 with PREBIO1TM

VANILLA4390034958 1-00-43900-34958-6 43900-0349-58

24 x 250 mL cartons/case

PEPTAMEN® 1.5 with PREBIO1TM

ULTRAPAK®4390034957 1-00-43900-34957-9 43900-0349-57

6 x 1000 mL bags/case

PRODUCT CODE UPC (GTIN) NDC FORMAT NUMBER PACKAGING

PEPTAMEN AF®UNFLAVORED

9871666370 0-07-98716-66370-0 98716-0663-6024 x 250 mL cartons/case

PEPTAMEN AF® ULTRAPAK®

9871676390 0-07-98716-76390-5 98716-0663-806 x 1000 mL bags/case

PRODUCT CODE UPC (GTIN) NDC FORMAT NUMBER PACKAGING

PEPTAMEN® WITH PREBIO1TM

VANILLA9871618185 1-07-98716-18185-0 98716-0181-85

24 x 250 mL cartons/case

PEPTAMEN® WITH PREBIO1TM ULTRAPAK®

9871622804 1-07-98716-22804-3 98716-0128-046 x 1000 mL bags/case

PRODUCT CODE UPC (GTIN) NDC FORMAT NUMBER PACKAGING

PEPTAMEN® INTENSE VHPUNFLAVORED

4390097235 1-00-43900-97235-7 43900-0972-3424 x 250 mL cartons/case

PEPTAMEN® INTENSE VHPULTRAPAK®

4390097267 1-00-43900-97267-8 43900-0972-666 x 1000 mL bags/case

ORDERING INFORMATIONNUTRIENTS

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