Pediatric Psychopharmacology National Institute of Mental Health.
-
Upload
hilary-melton -
Category
Documents
-
view
218 -
download
0
Transcript of Pediatric Psychopharmacology National Institute of Mental Health.
Pediatric Psychopharmacology
National Institute of Mental Health
Child and Adolescent Treatment and Preventive Intervention
Research Branch
Mission:
To promote, conduct, and coordinate federally funded research on the effects of treatment and prevention of mental illness in children and adolescents
Primary Research Questions
1. What is the efficacy/effectiveness and safety of the most commonly used treatment and preventive interventions?
2. How current interventions can be improved?
3. How novel interventions can be developed?
Primary Research Questions4. What is the long-term impact of
treatments?5. How to address treatment non-
response?6. Which interventions for which
patients?7. What is the impact of comorbidity?8. How do interventions work?
Child and Adolescent Treatment and Preventive Intervention Research Branch
CT - FY99 Funding Total: $40.5 millions
45%55%
Prevention
Treatment
Child and Adolescent Treatment and Preventive Intervention Research Branch
FY 99 Funds Treatment Research
($ 22.3 millions)
Combined Tx42%
Psychosocial Tx32%
Psychopharm26%
Child and Adolescent Treatment and Preventive Intervention Research Branch
Research funding in 1999 (millions):
Prevention $ 18.2 Psychosocial Tx $ 7.1 Psychopharm. $ 5.9 Combined Tx $ 9.3
Child and Adolescent Treatment and Preventive Intervention Research Branch
Major areas of funding by disorder(1999, in millions)
Depression $ 8.0 Anxiety $ 2.6 ADHD $ 2.5 Autism $ 2.2
Research
Units
Pediatric
Psychopharmacology
Network
Research Units on Pediatric
Psychopharmacology Research Units on Pediatric
Psychopharmacology
Network of research units devoted to multi-site clinical trials in children
Units are at academic research settings Main focus is on efficacy and safety of
psychotropic medications that are commonly used in children without adequate data
Established in 1996-1997 through competitive
contracts
Research Units on Pediatric
Psychopharmacology Research Units on Pediatric
Psychopharmacology
Columbia University L. Greenhill, M.D. Johns Hopkins University M. Riddle, M.D. Pittsburgh University B. Birmaher, M.D.
Yale University F. Volkmar, M.D. UCLA J. McCracken, M.D. Indiana University C. McDougle, M.D. Ohio State University M. Aman, Ph.D.
Research Units on Pediatric PsychopharmacologyResearch Units on Pediatric Psychopharmacology
Each RUPP has experts in child psychiatry, psychopharmacology, pediatrics, clinical trial design and methods
Data management center Network statistician The network as a resource available to potential
sponsors of clinical trials in children (e.g., NIH, industry, private foundations)
Research Units on Pediatric
Psychopharmacology Research Units on Pediatric
Psychopharmacology NIMH supports: Basic infrastructure for the units Data management center Specific protocols in areas that are:
Of public health importance Not funded, or unlikely to be
funded through grant mechanisms Not sponsored by industry
Research Units on Pediatric
Psychopharmacology
Research Units on Pediatric
Psychopharmacology
Some Multisite Protocols:
SSRI for Children with Anxiety Disorders Risperidone for Children with Autism and Behavioral Disturbances SSRI for Depressed Children with Bipolar Disorder Sequential Treatments for Children with Comorbid ADHD and Anxiety Disorders
TADSTreatment for Treatment for
Adolescents with Adolescents with Depression StudyDepression Study
Primary Aims
To compare the effectiveness of FLX, CBT,
COMB, and PBO for reducing MDD symptoms
and patient disability acutely. To compare the effectiveness of the three
active treatments (FLX, CBT, and COMB)
during long-term treatment. To compare the speed of response of FLX,
CBT and COMB.
TADS N=432 Age: 12-17 years Dx: major depression Design: parallel-group Tx: Med, CBT, CBT+Med, Placebo Sites: 10
Stages of Treatment Model
Stage I: Acute treatment for 12 weeks
Stage II: Consolidation for 6 weeks Stage III: Maintenance for 18 weeks Stage IV: One year open follow-up
Recently Funded Grants Relapse prevention in youths with
depression Treatment of SSRI-resistant depression
in adolescents Mood stabilizers for youths with bipolar Efficacy and safety of methylphenidate
in preschoolers with ADHD
Preschool ADHD Treatment Study
Age 3-5 yrs (N=198) vs. Age 6-8 yrs (N=66)
Screening/evaluation 8 weeksOpen titration 3 weeksPlacebo-controlled trial 12 weeksOpen maintenance 10 monthsBlinded discontinuation 6 weeks
Some areas in need of expansion
Schizophrenia and other psychoses Bipolar Depression in prepubertal children Autism Comorbid conditions