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Pecoraro Research Group - University of...
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Dendrimers (BLB) Pecoraro Research Group Vincent L. Pecoraro: [email protected] Webpage: https://sites.lsa.umich.edu/pecoraro-lab Toxic Metal Binding Sites Molecular Magnetism Lanthanide Luminescence Hydroxamic acid derivatives Metal salts M = Ring Metal M = Center Metal Dendrimers 16Cys 19Leu 12Leu N terminus C terminus GRAND-CSL16CL30H a site X-ray crystallography NMR structural determination Molecular Recognition/Catalysis Ru or Rh style catalyst Rational design to improve NiR activity Gated NiR Catalysis Carbonic Anhydrase (PDB 3PBJ) Spectroscopy 2 4 6 8 10 12 -3 -1 1 3 k/Å -1 k 3 ´ EXAFS 0 1 2 3 4 5 6 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 R/Å FT magnitude B C Superoxide Dismutase Asymmetric 3SCC Enzyme Design a b (c) d e f g a’ • Inductively Coupled-Plasma Optical Emission • Electronic Absorption • X-Ray Absorption • Heavy metal NMR • Circular Dichroism • Magnetic CD • Fluorescence • Stopped Flow • 111m Cd PAC • Fun trips to Stanford • Mass spectrometry • EPR • Electrochemistry Outside the Lab
Transcript of Pecoraro Research Group - University of...
Dendrimers (BLB)
Pecoraro Research GroupVincent L. Pecoraro: [email protected]
Webpage: https://sites.lsa.umich.edu/pecoraro-lab
Synthetic Method (BS / BLB)
MC (large MC image)
Toxic Metal Binding Sites
Molecular MagnetismLanthanide Luminescence
Hydroxamic
acid
derivatives
Metal salts M = Ring Metal
M = Center Metal
Dendrimers
16Cys
19Leu
12Leu
N terminus
C terminus
GRAND-CSL16CL30Ha site
X-ray crystallography
NMR structural determination
Molecular Recognition/Catalysis
Ru or Rh style catalyst
Rational design to improve NiR activity
Gated NiR Catalysis
Carbonic
Anhydrase(PDB 3PBJ)
Spectroscopy
2 4 6 8 10 12
-3
-1
1
3
k/Å-1
k3 ´ E
XAFS
0 1 2 3 4 5 60.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
R/Å
FT m
agnit
ude
A B
C
8960 8990 9020 90500
1
2
3
E/eV
Norm
alize
d In
tens
ity
Superoxide Dismutase
Asymmetric
3SCC
PECTIDES(large pymol) Enzyme Design
ab
(c)de
fg
a’
• Inductively Coupled-Plasma Optical Emission• Electronic Absorption• X-Ray Absorption• Heavy metal NMR• Circular Dichroism•Magnetic CD• Fluorescence• Stopped Flow• 111mCd PAC• Fun trips to Stanford• Mass spectrometry• EPR• Electrochemistry
Outside the Lab
