PBL 5
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Transcript of PBL 5
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CELL INJURY:MECHANISM &
CONSEQUENCES
4th September, 2015
Prepared by : PBL 5
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ADAPTATION VS CELL INJURY
Cell injury is a reversible or irreversible conditions which occur after the limits of adaptive response to a stimulus are exceeded
Cells may recover if the injury is mild and transient (reversible) but if the stress is severe and progressive, cell death occurs (irreversible)
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CAUSES OF CELL INJURY
Oxygen Deprivation (Hypoxia)Chemical Agents Infectious AgentsImmunological ReactionsGenetic FactorsNutritional ImbalancesPhysical AgentsAgeing
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REVERSIBLE INJURY
Cellular swelling: Inability to maintain ion and fluid homeostasis
Fatty change : Lipid vacuoles in the cytoplasm
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MECHANISMS OF CELL INJURY
Mitochondrial damage Influx of Calcium Ions Membrane damage Protein misfolding/DNA damage
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