Paul Richard Carney, M.D. - University of Florida...University of Florida College of Medicine and...

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CURRICULUM VITAE January 2011 Paul Richard Carney, M.D. Current Position Professor of Pediatrics and Neurology Joint Professor of Neuroscience and Biomedical Engineering Wilder Chair for Research in Epilepsy Chief of the Division of Pediatric Neurology Director of the Comprehensive Pediatric Epilepsy Program Attending Pediatric Neurologist Shands Children’s Hospital University of Florida College of Medicine and McKnight Brain Institute Gainesville, Florida, U.S.A. Address Department of Pediatrics Division of Pediatric Neurology University of Florida College of Medicine JHMHC, Room HD-410, Box 100296 Gainesville, Florida, USA 32610 Phone: 352-273-9328 Fax: 352-392-9802 Email: [email protected]; [email protected] Websites: http://www.neurology.peds.ufl.edu/carneylab/index.htm http://www.neurology.peds.ufl.edu Research laboratory : Biomedical Science Building Room J383 University of Florida, Gainesville, FL 32610 Synopsis Paul R. Carney, M.D., Professor and Chief of the Division of Pediatric Neurology at the University of Florida College of Medicine since 2003 and a full-time member of the Department since 1998. He holds the Wilder Chair Professor in Epilepsy, is Director of the University of Florida Comprehensive Pediatric Epilepsy Center, and Professor of Pediatrics and Neurology. He is Graduate Faculty and Joint Professor in Neuroscience and Biomedical Engineering. As Director of the Pediatric Neurology at the University of Florida, Dr. Carney has led the department to become one of the top pediatric neurology divisions in the United States and a national leader in epilepsy. He initiated comprehensive new programs addressing physician and

Transcript of Paul Richard Carney, M.D. - University of Florida...University of Florida College of Medicine and...

Page 1: Paul Richard Carney, M.D. - University of Florida...University of Florida College of Medicine and McKnight Brain Institute Gainesville, Florida, U.S.A. Address Department of Pediatrics

CURRICULUM VITAE

January 2011

Paul Richard Carney, M.D.

Current Position

Professor of Pediatrics and Neurology

Joint Professor of Neuroscience and Biomedical Engineering

Wilder Chair for Research in Epilepsy

Chief of the Division of Pediatric Neurology

Director of the Comprehensive Pediatric Epilepsy Program

Attending Pediatric Neurologist Shands Children’s Hospital

University of Florida College of Medicine and McKnight Brain Institute

Gainesville, Florida, U.S.A.

Address

Department of Pediatrics

Division of Pediatric Neurology

University of Florida College of Medicine

JHMHC, Room HD-410, Box 100296

Gainesville, Florida, USA 32610

Phone: 352-273-9328

Fax: 352-392-9802

Email: [email protected]; [email protected]

Websites: http://www.neurology.peds.ufl.edu/carneylab/index.htm

http://www.neurology.peds.ufl.edu

Research laboratory:

Biomedical Science Building Room J383

University of Florida, Gainesville, FL 32610

Synopsis

Paul R. Carney, M.D., Professor and Chief of the Division of Pediatric Neurology at the

University of Florida College of Medicine since 2003 and a full-time member of the Department

since 1998. He holds the Wilder Chair Professor in Epilepsy, is Director of the University of

Florida Comprehensive Pediatric Epilepsy Center, and Professor of Pediatrics and Neurology. He

is Graduate Faculty and Joint Professor in Neuroscience and Biomedical Engineering.

As Director of the Pediatric Neurology at the University of Florida, Dr. Carney has led the

department to become one of the top pediatric neurology divisions in the United States and a

national leader in epilepsy. He initiated comprehensive new programs addressing physician and

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scientist development. His efforts led to more than $10 million in federal funding to support

translational neuroscience and biomedical engineering research, and $6 million in philanthropic

funds to carry forward the research and educational missions.

Dr. Carney is an internationally recognized expert in the diagnosis and treatment of children

and adults with neurological disorders. His research has focused on the development of novel

diagnostic methods and more effective treatments for children and adults with epilepsy. He has

authored more than 300 articles, abstracts, books, and book chapters. He is a Fellow of The

American Neurological Association and The American Pediatric Society, honors bestowed on

clinical scientists in academic medicine whose accomplishments are deemed of high importance

and scientifically distinguished.

Dr. Carney has received 10 years of continuous funding support from the National Institutes

of Health, National Science Foundation, and Department of Defense for basic neuroscience and

neuroengineering research in epilepsy. Epilepsy is the third most prevalent neurological disorder

affecting more 50 million people worldwide. More than one-third of individuals with epilepsy

are refractory to current therapies. Dr. Carney has been awarded the University of Florida Faculty

Research Prize in Clinical Sciences, the highest honor offered by the University of Florida

College of Medicine, for his major and significant contributions to medical research. He was also

recognized for his teaching excellence with the University of Florida Department of Pediatrics

Teaching Excellence Award. He has authored three of the leading textbooks in Pediatric

Neurology, Epilepsy and Neurophysiology, and Sleep Medicine, and serves on three major

editorial boards - Computers in Biology and Medicine, Recent Patents on Biomedical

Engineering, and Journal of Pediatrics. Dr. Carney received his MD from the University of

Valparaiso School of Medicine. He completed his residency in pediatrics at Case Western

Reserve University - Rainbow Babies and Children’s Hospital in Cleveland Ohio, followed by

fellowships in Pediatric Neurology, Epilepsy and Clinical Neurophysiology, and Sleep Medicine

at The University of Michigan in Ann Arbor Michigan.

Education

High School: 1970-74 Chardon High School, Chardon, OH

Undergraduate: 1974-79 John Carroll University, University Heights, OH

Bachelor of Science

Graduate: 1982-90 University of Valparaiso College of Medicine

Doctor of Medicine (with honors)

Clinical Training

1992-94 Pediatric Internship and Residency

Case Western Reserve University: Department of Pediatrics

Rainbow Babies and Children’s Hospital, Cleveland, OH

Program Director: Robert Kliegman, M.D.

1994-96 Pediatric Neurology Fellowship

University of Michigan Medical Center

Departments of Pediatrics and Neurology, Ann Arbor, MI

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Program Director: Gihan Tennekoon, M.D.

1996-98 Neurophysiology and Clinical Epilepsy Fellowship

University of Michigan Medical Center

Department of Neurology, Ann Arbor, MI

Program Director: Ivo Drury, MBBCh

1997-98 Sleep Disorders Fellowship

University of Michigan Medical Center

Department of Neurology, Ann Arbor, MI

Program Director: Michael Aldrich, M.D.

Research Training

1981-83 Research Associate

Case Western Reserve University

Department of Neuroscience

Advisor: Jerry Silver, Ph.D., Raymond Lasek, Ph.D.

Area: Axon guidance during early peripheral auditory nerve development

1990-92 Post Doctoral Research Associate

University of Valparaiso: Cell Biology Department

Primary advisor: Professor Doctor Eduardo Couve

Area: Axon guidance and neuronal cell migration during early avian peripheral

auditory system development

Academic Appointments

1998-05 Assistant Professor of Pediatrics

University of Florida Department of Pediatrics

Gainesville, FL

1998-05 Adjunct Assistant Professor of Neurology

University of Florida Dept of Neurology

Gainesville, FL

2000- Graduate Faculty

University of Florida Graduate School, Colleges of Medicine, Engineering

Health Professions, Food and Nutrition Sciences, and Education

Gainesville, FL

2001-05 Affiliate Assistant Professor of Neuroscience

University of Florida Department of Neuroscience

Gainesville, FL

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2004-05 Affiliate Assistant Professor of Biomedical Engineering

University of Florida Department of Bioengineering

Gainesville, FL

2006-07 Associate Professor of Pediatrics and Neurology

University of Florida Departments of Pediatrics and Neurology

College of Medicine

Gainesville, FL

2007- Professor of Pediatrics and Neurology

University of Florida Departments of Pediatrics and Neurology

College of Medicine

Gainesville, FL

2007- Joint Professor of Biomedical Engineering

University of Florida Dept of Biomedical Engineering

College of Engineering

Gainesville, FL

2007- Affiliate Professor of Neuroscience

University of Florida Neuroscience Department

College of Medicine

Gainesville, FL

Administrative Appointments

1999- Medical Director

Comprehensive Pediatric Epilepsy Program

Neurodiagnostics Laboratory

University of Florida Health Center

Gainesville, FL

2001-02 Interim Division Chief

Division Pediatric Neurology

University of Florida Department of Pediatrics

Gainesville, FL

2002- Division Chief

Division of Pediatric Neurology

University of Florida Dept of Pediatrics

Gainesville, FL

2007- Director

Wilder Center for Epilepsy Research

University of Florida College of Medicine

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Gainesville, FL

Hospital Appointments

1998- Attending Pediatric Neurologist

University of Florida/Shands Children’s Hospital

1998- Medical Staff in Child Neurology

University of Florida/Shands Children’s Hospital

1998- Pediatric Epilepsy & Clinical Neurophysiology Staff Physician

University of Florida/Shands Children’s Hospital

1998- Pediatric Sleep Medicine Staff Physician

University of Florida and Shands Children’s Hospital

Honors

1980 Diamond-Shamrock Corporation Cooperative Educational Scholarship, Cleve, OH

1980 John Huntington Scholarship for Undergraduate Studies, John Carroll University

1985 National Research Service Award, National Science Foundation (Neuroscience)

1990 Doctor of Medicine (with Honors), University of Valparaiso College of Medicine

1998 Fellow of the American Academy of Pediatrics

1999 Teaching Excellence Award, Dept of Pediatrics, University of Florida

2000 Honorary Fellow of the Society for Pediatric Research

2004 William Pierskalla Best Paper Award

2004 Wilder Epilepsy Research Chair, University of Florida College

2006 Honorary Member, Chilean Child, Adolescent Psychiatry, & Neurology Society

2006 Tenure, University of Florida College of Medicine

2008 Wilder Chair Professor, University of Florida College of Medicine

2008-10 Best Doctors in America Honorary Award

2009 Faculty Research Prize in Clinical Science for Outstanding Achievements and

Productivity Research, University of Florida College of Medicine

2010 American Neurological Association – Elected Member

2010 American Pediatric Society – Elected Member

Certifications

Ohio Medical State License

Michigan Medical State License

Florida Medical State License

American Board of Neurology and Psychiatry, Inc. with Special Competence in Child Neurology

Non-Tenure and Entrepreneurial Activities

1980-81 Research Chemist

Diamond Shamrock Corporation: Cleveland, OH

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2005-07 Scientific Medical Director

Optima Neuroscience, Synogen Group, Gainesville, FL

Real-time brain function monitoring software development

2007- President

Chronobionics, LLC, Gainesville, FL,

Closed-loop seizure prevention device development

http://www.chronobionics.com

Memberships and Offices in Professional Societies

American Academy of Pediatrics

Federation of American Societies for Experimental Biology

University of Florida, McKnight Brain Institute

American Epilepsy Society

Russell N De Jong Society, University of Michigan

American Sleep Disorders Society

American Academy of Neurology

Alachua County Medical Society

American Association for the Advancement of Science

Biomedical Research Partnership for Brain Dynamics, University of Florida

Society for Pediatric Research, American Academy of Pediatrics

University of Florida, Child Research Institute

Center for Optimization, College of Engineering, UF of Electrical Engineering and Electronics

Child Neurology Society Active Member

American Academy of Neurology Scientific Sleep Abstracts Reviewer

Society for Neuroscience

Fund Raising Activities

Endowment: B.J. and Eve Wilder Endowment for excellence in epilepsy research $ 2M gift

(+$2M state match) 2005

Endowment: B.J. & Eve Wilder Professorship $ 800,000 (+$ 500,000 state match) 2007

Endowment: Damiano Gift for research in stuttering $ 1M gift (+$1M state match), 2007

Scientific Activities

Current Editorial Board Positions

2005- Editorial Board, Computers in Biology and Medicine

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2007- Editorial Board, Recent Patents on Biomedical Engineering

2007- Editorial Board, The Journal of Pediatrics

Current Journal Reviewer Activities

1998- Pediatric Neurology

Epilepsia

Journal of Child Neurology

1999- Journal of Clinical Neurophysiology

2002- Lippincott Williams and Wilkins Publishers

Psychosomatic Medicine

Basic and Clinical Pharmacology & Toxicology

ACTA Neuropsychiatrica

2004- Sleep

2004- Experimental Medicine and Biology Society IEEE

2004- Clinical Pediatrics

2005- Epilepsy and Behavior

2005- Computers in Biology & Medicine

2007- Journal of Pharmacology & Experimental Therapeutics

2007- Journal of Pediatric Neurology

2007- American Academy of Neurology (Sleep Section)

2007- The FASEB Journal

2008- Journal of Pediatric Neurology IEEE Transactions on Biomedical Engineering

American Academy of Neurology Scientific Abstract Reviewer

2009- EURASIP Journal on Advances in Signal Processing

Chaos

2010- Journal of Neural Engineering

Grant Reviewer

1999 American Epilepsy Society

2000- University of Florida, Division of Sponsored Research

2000- Canadian Research Council

2007- NIH Study Section: Member, ZRG1 ETTN-E 10 B, Clinical Neurophysiology,

Devices, and Neuroprosthetics, Panel on 6/07, 09/07, 02/08, 06/08, 10/08, 03/09

2007- Graduate Student for Outstanding Research, Office of Graduate Education, Office of

the Dean, College of Medicine, University of Florida, Gainesville, FL

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2007- Natural Sciences and Engineering Research Council of Canada

2008- NIH Study Section, Member, Neurotechnology Study Section Emerging Technologies

and Training Neurosciences Integrated Review Group, 10/08, 02/09

University of Florida Division of Sponsored Research, Research Opportunity Fund

2010- NIH Study Section Co-Chair: Member, SBIR ETTN-K 10, 02/10

NIH Study Section, Emerging Technologies and Training in Neurosciences IRG

03/10

NIH Study Section, Small Business: Clinical Neurophysiology, Devices, Auditory

Devices and Neuroprothesis. 2010/10 ZRG1 ETTN-K (10) B 06/24/2010-06/25/2010

Consulting Activity

1999-01 Cephalon, Inc.

2001- Glaxo Smith Klein, Inc.

2001-02 UCB Pharma

2002- Lippincott Wilkins and Williams Publishers

2003- Novartis, Inc.

2006 Sanofi Aventis, Inc.

2007 Greenley Associates

2008 Foresight Science & Technology, Inc.

2009- Cyberonics, Inc.

Teaching Activities

1997-98 Invited Lecturer, Neurology resident’s neuroscience lecture series, University Michigan, Ann Arbor, MI

1998- Teaching attending physician, Pediatric Neurology Series Dept of Neurology,

University of Florida

In-patient teaching attending, Pediatric Neurology, University of Florida

Out-patient teaching attending, Ped Neurology, Epilepsy/Sleep Disorders Clinic, University of Florida

Lecturer, Neonatal Fellows Seminar Conf, Div of Neonatology, Dept. Pediatrics, University of Florida

General pediatrics morning conference attending, Dept. of Pediatrics, University of Florida

Lecturer, Pediatric Neurology Morning Conference, Dept. of Pediatrics, University of Florida

Lecturer, Epilepsy, Clinical Neurophysiology, and Sleep Medicine, UF Dept Neurology

1999- Oral examiner, second year medical students, UF College of Medicine

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2001- Teaching Preceptor, Biomedical Engineering, University of Florida, BME 6010

Clinical Shadowing Course, University of Florida College of Engineering

2004- Lecturer, Neuroscience course GMS6007, UF Department of Neuroscience

Member, Neurology Residency Advisory Committee, UF Department of Neurology

Lecturer, Neuroscience course GMS 6007, UF Department of Neuroscience

2005- Faculty Preceptor, MEL 4012 Undergraduate Physician Shadowing Program

2007- Lecturer, Physiology Graduate Level Course, UF Dept Biomedical Engineering

Courses Developed and Taught

2005- Biomedical Engineering BME 6010, Credit 3, Title, Clinical Preceptorship, Department Bioengineering, University of Florida College of Engineering, Summer, Fall, Spring Semesters, 20-30 students per semester.

University of Florida Graduate Student Activities

Doctoral Dissertations Committees: Chair/Co-Chair

2000-03 Sobha Fritz, Department of Child Psychology

Thesis: Maternal-child adherence in childhood epilepsy

Current position: Faculty, Emory University, Atlanta, GA

2001-05 Greg Selke, Department of Neuropsychology, College of Health Professions

Thesis: Emotional Reactivity to Picture Stimuli in Children in Children with and

without Attention-Deficit/Hyperactivity Disorder

Current position: Faculty, Brown University, Providence, RI

2001-04 Danielle Becker, Department of Neuropsychology

Thesis: Relation between sleep and epilepsy in children

Current position: Neurology resident, University of Pennsylvania

2002-06 Sandeep Nair, M.S., Dept of Bioengineering, College of Engineering

Thesis: Quantitative EEG signal analysis in rat limbic epilepsy model

Post Doc: Allegheny Universtiy, Pittsburg, PA

2003-08 Susan Bongiolatti, Department of Neuropsychology

Thesis: Frontal lobe dysfunction in childhood epilepsy & cognitive problems in

children with sleep disorders and epilepsy

Current position: Faculty, Case Western Reserve University, Cleveland, OH 2006-10 Rabia Zafar, Department of Neuroscience

Topic: Epilepsy gene therapy

2006-10 Mansi Parekh, Interdisciplinary Program, Department of Neuroscience

Topic: MRI and epileptogenesis in an animal model of limbic epilepsy

Current position, Post Doc University of Florida, Gainesville, FL

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2007-09 Jason Winters, Department of Biomedical Engineering

Topic: Real-time brain monitoring

Current position: Industry, Charlottesville, VA

2007-10 Stephen Meyers, Department of Biomedical Engineering

Topic: Closed-loop seizure prevention

Current position: Post Doc, University of Florida, Gainesville, FL

2008- Svetlana Kantorovich, Interdisciplinary Program, Department of Neuroscience

Topic: Convection enhanced drug delivery in epilepsy

2009- Francisco Delgado UF College of Engineering, Dept of Biomedical Engineering

Topic: Nanotechnology and epilepsy

Graduate Student Committee Member

1998-99 Jodi Passman, UF Department of Food and Agricultural Science

Thesis: Ketogenic diet and epilepsy

2000-01 Tran Ai Hang, UF Department of Food and Agricultural Science

Thesis: Ketogenic diet efficacy in epilepsy

2003-08 Anil Bollimunta, UF Dept of Biomedical Engineering, College of Engineering

Thesis: Techniques for analysis of neural activity: spontaneous and evoked

2003-05 Mandy Layman, UF Department of Food Science

Thesis: Ketogenic diet in intractable childhood epilepsy

2004-08 Chang-Chia Liu, UF Dept of Biomedical Engineering, College of Engineering

Thesis: Brain dynamics, system control and optimization techniques with

application in epilepsy

2005-08 Alex Cadotte, UF Dept of Biomedical Engineering, College of Engineering

Thesis: Non- linear dynamics for discrimination of pharmaceutical agents

on MEA's

2007-08 Nicole Nasewicz-Pies, UF Dept of School Psychology, College of Education

Thesis: Recognizing, differentiating, and referring students with absence

seizures: what factors affect pre-service teachers’ decision-making?

2007-08 Chelsey Durgin, UF Biomedical Engineering Dept,

Topic: Diffusion Tensor Imaging and Epilepsy

2006-08 Hector Selpulveda, UF Department of Biomedical Engineering

Topic: MRI and epilepsy

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2006-10 Mamta Wankhede, UF Department of Biomedical Engineering

2006-10 Mackenzie E. Hoffmann, UF Interdisciplinary Program, Dept of Neuroscience

Topic: Expanding the role of cannabinoids in the synaptic physiology of the

hippocampus

2008-10 Adam D. Fletcher, UF Department of Biomedical Engineering

Topic: A computational study of flow and mass transport in intrathecal drug

delivery

2007- Phil Barish, UF Department of Biomedical Engineering, College of Engineering

Topic: Optogenetics and epilepsy

2009- Katherine Follansbee-Junger, UF Department of Neuropsychology

Topic: Examining the contribution of health behaviors and psychological

functioning I anti- epileptic drug induced weight gain among children with

epilepsy.

2010- Jigesh Dalal, UF Department of Biomedical Engineering

Clinical Pre-Medical Research

2000-01 Scott Palmer, University of Miami Medical School

2000-01 Tang Tran, University of Florida College of Medicine

2001-02 Jonathan Day, Uniformed Services University

2002-03 Meadow Maze, University of Arizona

2002 Ryan Asdourian, University of Florida

2007-08 Angela Brown, University of Florida

2007-09 Richard Schatz, Washington University

2008 Kathryn P. Helmick, University of Florida

Post-Doctoral Fellows Supervised

2003-08 Wendy Norman, D.M.V., Ph.D.

Project title: Seizure Prediction in the Rat Chronic Limbic Epilepsy Model

Current position: Faculty, University of Florida Dept Veterinary Medicine

2004-06 Justin C. Sanchez, Ph.D.

Project title: Hybrid Brain Machine Interface in Epilepsy

Current position: Faculty, University of Miami Dept Biomedical Engineering

2005-07 Greg Selke, Ph.D.

Project title: Relation between Sleep Disorders and ADHD

Current position: Faculty Brown University, Providence, RI

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2006-09 Sachin Talathi, Ph.D.

Project title: Evolution into Epilepsy, Epilepsy Chronobiology

Current position: Faculty, University of Florida

2007-08 Dan Tarquinio, D.O, Research Neurology Fellow

Project: Rett Syndrome

(Co-Mentor’s Dr. Alan Percy, UAB, Dr. Dan Driscoll, UF

Current position: Neurology fellow, Boston University, Boston, MA

Current Post-Doctoral Fellows

2008- Alex Cadotte, Ph.D.

Project title: Effective Connectivity and Epilepsy

2008- Junli Zhao, M.D., Ph.D.,

Project title: Place cells activity in epilepsy

2009 Mansi Parekh, Ph.D.

Project title: Structural analysis in epilepsy

2009 Rabia Zafar, Ph.D.

Project title: Gene therapy in epilepsy: somatostatin and channel rhodopsins-2

Clinical Fellows Supervised

1998-99 Terry Bunch, M.D., Fellowship in Pediatric Neurology

2000-01 Brenda Wu, M.D., Ph.D., Fellow in Clinical Neurophysiology

2003-04 George Gacibieu, M.D., Fellow in Clinical Neurophysiology

Advisor to Pediatric Residents

1999- Advisor/Mentor Program, first-year medical students

2003-04 Liliana Petrova, M.D., Pediatric resident

Faculty Medical Student Advisor

2007-09 Richard Schatz Epilepsy animal models Medical Student, University of Florida

2008 (Summer) Advisor: Jenny Wilkerson, MSRP Fellowship (Summer, 2008)

Project: Relationship between sleep disturbance and daytime behavioral

problems in children with epilepsy

2008-09 Kathryn Helmick Epilepsy animal models Medical Student, UF

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2010 (Summer) Yeong Jung Park College of Medicine Medical Student Research Program,

Identifying Structural and Functional Correlates in Children and Adults with

Medically Intractable Epilepsy, Medical Student, University of Florida

College of Medicine

Local Committee and Administrative Services

1998 Biocomputing 2001, University of Florida, College of Engineering

1998 Conference Co-Organizer for Quantitative Neuroscience: Models, Algorithms,

Diagnostic and Therapeutic Applications Conference University of Florida

1998- University of Florida, EEG & Epilepsy Monitoring Unit Planning Committee Shands

Children’s Hospital

2000 University of Florida, Sleep Disorders Program Planning Committee

2000-03 Department of Pediatrics Strategic Planning Committee

2000-04 Department of Pediatrics Outpatient Clinic Planning Committee

2000 University of Florida Sleep Disorders Program Planning Committee Shands

Children’s Hospital

2001 Quantitative Neuroscience/Neural Engineering Seminar, University of Florida

McKnight Brain Institute, Weekly Seminar Fall & Spring Semesters

2001 Epilepsy Services of Florida

2001 NIH sponsored “Brain Dynamics Biomedical Partnership

2001 Co-Coordinator, Quantitative Neuroscience/Neural Engineering Seminar University

of Florida McKnight Brain Institute.

2002 Quantitative Neuroscience: Models, Algorithms, Diagnostic & Therapeutic

Applications, Univ. Florida

2003 Department of Neurology Epilepsy Faculty search committee, University of Florida

Division of Critical Care Faculty search committee, Dept of Pediatrics, University of

Florida

2003 Data Mining in Biomedicine, University of Florida, College of Engineering and

McKnight Brain Institute

2003 Quantitative Neuroscience/Neural Engineering Seminar Graduate Course in

Biomedical Engineering, University of Florida College of Engineering and McKnight

Brain Institute

2003 Dept of Bioengineering Faculty Search Committee, University of Florida College of

Engineering 2004-05

2003 University of Florida McKnight Brain Institute Director search committee

2003 Conference Co-organizer, Quantitative Neuroscience: Models, Algorithms,

Diagnostic and Therapeutic Applications Conference, University of Florida

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2003-08 Medical Advisor to NICA, Tallahassee, FL State of Florida

2004-05 Advisory Board, Data Mining in Biomedicine, UF College of Engineering

2004- Center for Applied Optimization, University of Florida, College of Engineering and

McKnight Brain Institute

2004-07 Search Committee for Department of Biomedical Engineering, University of Florida

College of Engineering

2005- Academic Graduate Committee, Dept of Biomedical Engineering, University of

Florida College of Engineering

2005 Co-Organizer, Conference on Systems Analysis, Data Mining, and Optimization in

Biomedicine, University of Florida Feb. 2-4, 2005

2005 Ad Hoc Advisory Board Member, Dept. Biomedical Engineering, College of

Engineering, University of Florida (May, 2005)

2005 Scientific Judge, Lincoln Middle School Science Fair, Gainesville, FL, Feb, 05

2006 Advisory Board, DIMACS Workshop on Data Mining, Systems Analysis, and

Optimization in Neuroscience, University of Florida, Gainesville, FL,

2006 Advisory Committee, Conference on Data Mining, Systems Analysis and

Optimization in Neuroscience February 15-17, 2006. University of Florida

2008 University of Florida College of Medicine Neurology Chair search committee

2009 University of Florida College of Medicine M.D./Ph.D. Program

National Committee and Administrative Services

1998 Platform Moderator, American Epilepsy Society

2001- Committee Member, American Epilepsy Society, Special Interest Group

2005 Invited Guest, National Science Foundation, Collaborative Research Computational

Neuroscience, Bethesda, MD, March, 05

2007-08 Member, American Epilepsy Society Scientific Program Committee

2008 Sleep Abstracts Reviewer, American Academy of Neurology

2008 Scientific Abstract Reviewer, American Epilepsy Society Annual Meeting

2008-12 Member, American Epilepsy Society Scientific Program Committee

2008 Scientific Abstract Reviewer, American Academy of Neurology 61th Annual Meeting

2008 Advisory Board, College of Engineering Department of Biomedical Engineering

University of Florida, October 16-17, 2008

2008-09 Member of the Advisory Committee, Fourth International Workshop on Seizure

Prediction spring, 2009

2009 Scientific Abstract Reviewer, American Academy of Neurology 61th Meeting

2009-12 Member, Pediatric Content Committee, American Epilepsy Society

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2010 Co Chair, American Academy of Neurology's Science Committee and Scientific

Program Subcommittee, S04: Sleep Disorders, April 13, 2010, 62nd

Annual Meeting

of the American Academy of Neurology, April 10 to April 17, Toronto

2010 Chair, Clinical Epilepsy Nanosymposium, Society for Neuroscience, November 14,

2010, San Diego, CA

Patents, Patent Invention Disclosures and Copyrights

1. Real-Time Brain Monitoring System

Inventors: Paul R. Carney, MD, J. Chris Sackellares, MD, Deng Shaiu, Ph.D.

UF Provisional Patent UF#-11220

2003

2. Multi-Dimensional Multi-Parameter Time Series Processing for Seizure Warning &

Prediction

Inventors: J. Chris Sackellares, MD, Paul R. Carney, MD Type: Provisional Patent UF#-No

028724-143

2003

3. Closed-Loop Micro-Control System for Predicting and Preventing Epileptic Seizures

Inventors: Justin Sanchez and Paul R. Carney

UF Provisional Patent UF#- 63815P(49163)

2005

4. Real-Time Brain Monitoring System,

Inventors: Paul R. Carney, MD, J. Chris Sackellares, MD, Deng Shiau, Ph.D. Type:

Provisional Patent UF#-#-11220

February 25, 2005

5. Interactive Dynamical Brain Monitoring and Neuro Diagnostic Systems

Inventors: Sackellares JC, Carney PR, and Shiau DS. (Attorney Docket No. 028724-

144.001United States Patent Application Number 11/065,703).

UF Provisional Patent UF

February 25, 2005

6. State Dependent, Direct and Model-based Closed-loop Seizure Control System

Inventors: Sackellares JC, Principe JC, Shiau DS, Pardalos PM, Carney PR, Cho J, Nair SP

Suharitdamrong W and Dance LK.

UF invention disclosure # – 11926.

2005

7. Neuromodulation of Excitation and Inhibition to Control Epilepsy and Neurological

Disorders

Inventors: Ditto, WL, Carney PR, Talathi S, Hwang, DU.

UF Invention disclosure UF # 12785

February 11, 2008

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8. Real-Time Brain Monitoring System

Inventors: Paul R. Carney, J. Chris Sackellares, Deng Shaiu

Patent Number 7433732

October 7, 2008

9. Magnetic Resonance Compatible and Susceptibility-Matched Apparatus and Method for MR

Imaging and Spectroscopy

Inventors: Thomas Harold Mareci, Paul Richard Carney, Garrett William Astary and Hector

Sepulveda

Application Number 61/232,288

August 7, 2009

10. Optically Active Opioid Receptors for the Treatment of Chronic/Acute Pain

Inventors: William Ogle and Paul R. Carney

Application Number 13317

2009

11. Detecting Epileptogenesis

Inventors: Sachin S. Talathi, Paul R. Carney, Dong-Uk Hwang, William L. Ditto

Attorney Docket No.: 450-P0005US

November, 2010

GRANT SUPPORT

Current Research Grant Support

Title: CRNCS: Evolution into Epilepsy

Agency: NIH R01-EB004752-01

Dates: 09/01/04 – 06/30/10

Effort: 1.8 calendar

Role: MPI

Direct: $1,287,170

Summary: The basic project goals are to use our computational algorithms and models to

evaluate potential hypothesis on the underlying functional and structural mechanisms of

epileptogenesis in a validated animal model of temporal lobe epilepsy.

Title: CRCNS: Automatic Prediction of the Onset of Epilepsy via Analysis of High Angular

Resolution Diffusion MRI

Agency NIH NIBIB R01 EB007082-02

Dates: 08/01/06 to 05/31/10

Effort: 1.2 calendar

Role: MPI

Direct: $1,296,877

Summary: The major goals of this study are to develop a computational algorithm for MR high

angular resolution diffusion imaging de-noising and estimation of the field of probability

densities. Then to develop and validate an atlas-based segmentation scheme that allows

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computation of fiber tracts and the signature of structural changes, during the period of

epileptogenesis, and predict the time of onset of epilepsy.

Title: Computational Transport Models for Convection-Enhanced CNS Delivery

Agency: NIH R01 NS063360

Dates: 07/01/08 to 07/31/13

Effort: 1.2 calendar

Role: MPI

Amount: $1,505,597

Summary: The goal of this study is to provide a fundamental understanding of convection

enhanced delivery of compounds into the hippocampus for the treatment of temporal lobe

epilepsy.

Title: Balanced Polyvalent Anti-Glutamatergic Action as a Novel Approach to Efficacious

Neuroprotection

Agency: NIH R21 NS060862-01A1 (Martynyuk, A)

Dates: 2008 to 2010

Role: Consultant

Summary: This study tests the hypothesis that in newborn rats, anesthetics that enhance GABA

A/glycine receptor activity may depolarize the neuronal membrane potential, trigger seizures, and

cause neurotoxicity.

Title: Photoacoustic Tomography of Epilepsy

Agency: Congressionally Directed Statement Medical Research Programs (USAMRMC)

Department of Defense ASDRP, Department of the Army

Role: PI (with J. Jiang)

Dates 04/01/09 to 03/31/13

Effort: 2.4 calendar

Summary: The underlying hypothesis of this application is that laser-induced photoacoustic

tomography provides a new high resolution, functional neuroimaging modality for imaging

epilepsy.

Title: Noninvasive Functional and Cellular Imaging of Epilepsy

Agency: NIH 1R01NS069848-01

Dates: 02/15/2010 to 01/31/2014

Effort: 1.8 calendar

Role: MPI

Summary: The primary goal of this project is to develop a DOT system for accurate localization

of epileptic focus. We also propose to study the neuro-vascular and neuro-cellular coupling of

neuronal activity and hemodynamic/cellular response using concurrent EEG and DOT

noninvasively in an epilepsy animal model.

Title: Control of Neural Synchrony with Light-Activated Opsins Working Group

Agency: University of Florida Computational Biology Working Group Seed Grant RFA

Direct: $80,000

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Dates: 04/01/10 to 03/31/11

Role: MPI

Agency: Cyberonics, Inc

Seizure prediction and detection

Dates: 10/01/10 to 09/30/11

Role: PI

Amount: $100,000

Pending Research Grant Support

Title: Brain-susceptibility-matched electrodes and cannula for distortion-free MR

Agency: NIH/NINDS

Role: PI

Dates: 04/01/2011 to 03/31/2013

Title: Ultrasound to control epilepsy: Sonoluminescent activation of neuron ion channels

Agency: NIH/NINDS

Role: Co-PI

Dates: 04/01/2011 to 03/31/2013

Title: Predicting Epilepsy in Limbic Brain Networks Derived from Diffusion MR Imaging

NIH/NINDS

Role: PI

Dates: 04/01/2011 to 03/31/16

Effort: 1.8 calendar

Title: Enhanced MR Imaging of Epileptogenesis with Histological Validation

Agency: NINDS/NIH

Dates: 07/01/08 to 06/30/11

Role: PI

Effort: 1.8 calendar

Title: Do GABA-ergic Anesthetics Generate Excitotoxicity in Neonates and Infants during

General Anesthesia?

Agency: NINDS/NIH (Martynyuk)

Dates: 04/01/09 to 03/31/11

Effort: 0.6 calendar

Score 10th

percentile, funding pending

Summary: The goal of this project is to assess the excitotoxicity effects of GABA in young

rodent pups.

Title: Early Diagnosis of Autism Using High-Angular-Resolution Diffusion Magnetic Resonance

Imaging

Agency: USAMRMC

Role: PI

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Dates: 11/01/08 to10/31/11

Effort: 1.8 calendar

Summary: The major goals of this project are to develop optimized MR HARDI acquisition

protocols, novel computationally efficient algorithms for MR HARDI denosing, to visualize the

displacement probability density field of white matter tracks in individuals with autism. We then

plan to use these methods to predict the onset of autism in young children.

Title: Collaborative Research in Computational Neuroscience: Chronobiology of Epilepsy

Agency: NSF CRCNS (Carney)

Dates: 01/01/09-12/31/13

Effort: 2.4 calendar

Summary: The goal of this research is to understand the influence of endogenous circadian

control on hippocampus postsynaptic activity in a rat model of limbic epilepsy.

Title: Spatial Measures of Connectivity for Early Seizure Prediction

Agency: Epilepsy Foundation of America

Dates: 01/10/09 to 12/31/09

Role: Postdoctoral Mentor to Post Doc Alex Cadotte, Ph.D.

Amount: $45,000

Summary: The primary aim of this study is to investigate measures of effective connectivity

during seizures in a rat model of temporal lobe epilepsy

Title: Enhanced MR Imaging of Epileptogenesis with Histological Validation

Agency: NIH R21 NS065359

Dates: 04/01/09-03/31/11

Role: PI

Effort: 1.2 calendar

Summary: This work focuses on the development of enhanced magnetic resonance for the study

of the structural changes that lead to the development of epilepsy. MR results are statistically

correlated with brain dynamic measures from multisite local field recordings and co registered

with quantitative histology.

Title: Develop and Validate a Transport Model of Adeno-Associated Viral Vector Convection

Enhanced Delivery for the Treatment of Epilepsy

Agency: UF Research Opportunity Fund

Dates: 01/01/09-12/31/09

Summary: This study tests the hypothesis that convection-enhanced delivery of adeno-associated

viral vector can be optimized by measuring and predicting the spatial and temporal distribution

of the vector transport in the brain.

Title: Cerebrospinal Fluid Flow Analysis for Intrathecal Drug Delivery

Agency: UF Research Opportunity Fund

Role: PI

01/01/09-12/31/09

Summary: The goal of this research is to develop a predictive model for intrathecal delivery.

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Title: Convection-Enhanced Delivery of Valproate-loaded Nanoparticles for Early Treatment of

Epilepsy

Agency: NIH RO1 Trans-NIH Recovery Act Research Support

Role : MPI

Dates: 10/01/09-09/30/11

Effort: 1.8 calendar

Summary: In this study we propose to provide neuroprotection through local delivery of a

histone deacetylase inhibitor drug, valproic acid, and determine if there is disruption of disease

progression in an established model of rat epilepsy. High concentrations of the drug, greater than

can be achieved through systemic delivery, will be achieved at the injury site using a novel drug

release system, direct tissue infusions of drug-loaded nanoparticles.

Title: CRNCS: Evolution into Epilepsy

Agency: NSF/NIH NIBIB R01-EB004752-01

Dates: 12/01/09 – 11/30/14

Effort: 2.4 calendar

Role: PI

Amount: $1,836,574.00

Summary: The basic project goals were to use our computational algorithms and models to

evaluate potential hypothesis on the underlying functional and structural mechanisms of

epileptogenesis in a validated animal model of temporal lobe epilepsy.

Title: Magnetoelencephalography

Agency: NIH Recovery Act Limited Competition: High-End Instrumentation Grant Program

(S10)

Role: PI

Title: Vagus Nerve Stimulation in an Animal Model of Chronic Limbic Epilepsy

Agency: NIH R21

Dates: 07/01/10-06/30/12

Effort: 1.2 calendar

Role: MPI

Summary: The aims of this project are to first test the efficacy of standard clinical vagus nerve

stimulation in a chronic model of limbic epilepsy and second to employ well-established

quantitative EEG tools in order to indentify the changes in brain dynamics in treatment

responders. The proposed research will provide the basis for a more extensive study of how to

develop more clinically efficacious VNS programming strategies through a better understanding

of the underlying changes in brain dynamics and periodic VNS.

Previous Research Grant Support

Title: Dichloroacetate Kinetics, Metabolism and Toxicity

Agency: NIH/NIEHS RO1

Dates: 07/01/04 to 06/30/09

Effort: 0.6 calendar

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Role: Co-I (Stacpoole, PW)

Summary: This multicenter study investigates the natural history of childhood mitochondrial

cytopathy. DCA is employed as experimental compounds in order to ameliorate the effects of

lactic acidosis.

Title: Postdoctoral Fellowship- Statistical Performance Analysis of Early Seizure Detection

Algorithms

Agency: Epilepsy Foundation of America

Dates: 01/01/08 to 12/31/08

Role: Postdoctoral Mentor for Sachin Talathi

Amount: $40,000

Summary: The goal is to develop and validate a mathematical algorithm for seizure detection in

a validated rat model of temporal lobe epilepsy.

Title: Bioengineering Research Partnership in Brain Dynamics

Agency: NIH R01 EB002089

Dates: 07/19/01 to 04/30/07

Effort: 4.8 calendar

Role: MPI

Summary: The goal of the Brain Dynamics Bioengineering Research Partnership was to

develop an on-line, real-time Automated Seizure Warning and Prevention System for use by

epileptic patients and their caregivers.

Title: On-Line Real-Time Seizure Prediction

2006-07

Role: Co-PI

NIH/NINDS (R01-NS050582-01A1)

Amount: $2,382,724

Title: Novel Anti-Epileptic Drug Discovery: Somatostatin Receptor Modulation for Treating

Epilepsy

2004-06

Research Opportunity Fund Competition, Division of Sponsored Research, University of Florida

Role: PI

Amount: $100,000

Title: An EEG Method for Real-Time Detection of Neonatal Seizures in the Neonatal Intensive

Care Unit

2003-06

Epilepsy Foundation of America Partnership for Pediatric Epilepsy Research Foundation

Role: PI

Amount: $75,000

Title: Outcome of Therapeutic Hypothermia in Pediatric Arrest

R21 HD 044981

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2003 -06

NIH/NICHD

Role: Co-I

$290,000

Title: Pediatric Epilepsy Program

Agency: Children’s Miracle Network Grant # 98HS-001

Amount: $2,587

Role: PI

Dates: 1998-99

Title: Epilepsy Monitoring Program

Agency: Children’s Miracle Network Grant # 98HF-015

Role: PI

Amount: $48,000

Dates: 1998-99

Title: Dynamical On-Line Real-Time Seizure Warning and Treatment in an Epilepsy-Prone

Rodent Model

Agency: University of Florida Division of Sponsored Research Opportunity Fund

Amount: $50,000

Role: PI

Dates: 2001-02

Title: In Vivo Neurophysiologic Characterization of the Epilepsy-Prone Sphingosine 1

Phosphate Receptor H218 Knockout Mouse

Agency: Children’s Miracle Network Grant

Role: PI

Amount: $40,000

Dates: 2000-01

Title: Dynamical Studies in Generalized Childhood Epilepsy

Agency: Biomedical Engineering Program

Dates: 1999-00

Role: PI

Amount: $25,000

Title: The Relationship between Sleep-Related Breathing Disorders and Hearing in Children

Agency: University of Florida College Investment Fund

Amount: $8,612

Role: PI

Dates: 1998-01

Title: Epilepsy Surgery Program

Agency: Children’s Miracle Network Grant # 99S-035 Intramural Patient

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Amount: $16,700

Dates: 1999-00

Title: Sleep Disorders Center

Agency: Children’s Miracle Network Grant # 99S-056

Amount: $7,500

Role: PI

Dates: 1999-2000

Title: Pediatric EEG/Sleep

Agency: Children’s Miracle Network Grant # 2000-044

Amount: $3,330

Role: PI

Dates: 2000-01

Title: Ketogenic Eggnog versus Ketogatornog Treatment for Seizures

Agency: Ross Foods, Inc.

Role: PI

Amount: $3,500

Dates: 1998-01

Title: Prevention of Dicloroacetate Toxicity

Agency: FD-R-002013-01

Role: Co-I

Amount: $880,000

Dates: 2001-04

Title: Subcortical Executive Function and Frontal Lobe Childhood Epilepsy

Agency: Epilepsy Foundation of America

Role: Mentor for Susan Bongiolatti Doctoral Student

Amount: $40,000

Dates: 2004-05

Title: On-Line Real-Time Seizure Prediction in Adult Patients with Epilepsy

Agency: Office of Technology Licensing, University of Florida Division of Sponsored Research

Amount: $26,872

Dates: 2004-05

Title: A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Stratified, Parallel-Group

Trial of the use of Telecommunications in Evaluating Compliance in Teen Epilepsy

Agency: NIH

Dates: 1998-03

Title: Home-based telecommunication mediated counseling for rural teens with epilepsy: multi-

point group vs. single family approaches

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Agency: NIH (NINDS)

Dates: 1998-03

Title: Preictal detection and seizure prevention in a transgenic mouse model of childhood

epilepsy

Agency: Children’s Miracle Network

Amount: $1,000

Dates: 2001-02

Title: Dichoroacetate Treatment of Congenital Acidosis

NIH, PA-94-036

$1,005,282

1998-00

Past Industry Research Support

Title: Rufinamide as adjunctive therapy in children and adults with inadequately controlled

partial seizures,

Novartis, Inc.,

1998-99

Title: In patient rufinamide as adjunctive therapy in children and adults with inadequately

controlled partial seizures

Novartis, Inc.

2000-01

Title: A multi-center, double-blind, randomized, placebo-controlled, parallel-group evaluation of

lamotrigine adjuntive therapy in subjects with primary generalized tonic-clonic seizures

Glaxo-Wellcome, Inc.

2001-02

Evaluation of the efficacy and tolerability of Levetiracetam add on treatment in refractory

pediatric patients with partial onset seizures

GlaxoSmithKline Grant # LAM40013

2002-03

Title: A Multicenter, Open label conversion of valproate monotherapy to lamotrigine

monotherapy in patients with epilepsy

Abbott Pharmaceuticals, Inc.

2002-03

Title: A multicenter, open label conversion of valproate monotherapy to lamotrigine

monotherapy in patients with epilepsy

GlaxoSmithKline Grant # LAM 40013

2002-04

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Title: Evaluation of the efficacy and tolerability of levetiracetam add-on treatment in refractory

pediatric patients with partial onset seizures: A 28-week double-blind placebo-controlled

multicenter trial

UCB Pharma Inc.

2002-03

Title:A multi-center open label, pilot study of lamotrigine as adjunctive therapy and

monotherapy in patients with epilepsy and co morbid depressive symptoms

GlaxoSmithKline Grant # LAM40117

2002-03

BIBLIOGRAPHY

Completed Publications in Scientific Journals

Peer-Reviewed Papers

1. Carney PR and Silver J. Studies on cell migration and axon guidance in the developing

distal auditory system of the mouse. J Comp Neur. 1983; 225:359-369.

2. Poston MR, Fredieu J, Carney P, Silver J. The role of glia and neural crest cells in creating

axon pathways and boundaries in the vertebrate central and peripheral nervous systems. In:

The Making of the Nervous System. Oxford University Press, Parnavelas JG, Stern CD,

Stirling RV, Eds. 1986, 282-313.

3. Carney PR, Couve E. Cell polarity changes and migration during early development of the

avian peripheral auditory system. Anat Rec.1989; 215:156-164.

4. Okun MS, Jummani RR, Carney PR. Antiphospholipid- associated recurrent chorea and

ballism in a child with cerebral palsy. Pediatr Neurol. 2000; 23(1):62-3.

5. Tran TX, Day JA, Eskin TA, Carney PR, Maria BL. Rasmussen’s syndrome: Etiology,

clinical features, and treatment options. CNS Drugs 2000; 14:343-354.

6. Kohrman MH, Carney PR. Sleep-related disorders in neurologic disease during childhood.

Pediatr Neurol. 2000; 23 (2):107-13.

7. Kramer MJ, LaRussa P, Tsai W, Carney P, Leber S, Gahagan S, Steinberg S, Blackwood A.

Disseminated vaccine strain varicella as the acquired immunodeficiency syndrome-defining

illness in a previously undiagnosed child. Pediatrics 2001; 108(2): e39-46.

8. Carney PR, Paige P. Neurologic Disorders. In: Handbook of Neonatal Intensive Care. Eds.

Merenstein, GB, Gardner SL. Pub. Mosby, 5th

ed. 2001; 644-678.

9. Carney PR. Rasmussen’s syndrome: Intractable epilepsy and progressive neurological

deterioration from a unilateral central nervous system disease. CNS Spectrums

2001;6(5):398-416.

10. MacLennan AJ, Carney PR, Zhu WJ, Chaves AH, Garcia J, Grimes JR, Anderson KJ, Roper

SN, Lee N. An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate

receptor in neuronal excitability. Eur J Neurosci. 2001; 14(2): 203-9.

11. Carney PR, Korhman, MH. Relation between epilepsy and sleep during infancy and

childhood. In: Sleep and Epilepsy: The Clinical Spectrum. Eds. Malow BM, Bazil C,

Sammaritano M. Pub. Elsevier Science 2002; 359-372.

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12. Glueckauf RL, Fritz SP, Ecklund-Johnson EP, Liss HJ, Dages P, Carney P.

Videoconferencing-based family counseling for rural teenagers with epilepsy: Phase 1

findings. Rehab Psychol. 2002; 47(1):49-72.

13. Iasemidis LD, Pardalos PM, Shiau DS, Chaowolitwongse W, Narayanan K, Kumar S,

Carney PR, Sackellares JC, Prediction of human epileptic seizures based on optimization

and phase changes of brain electrical activity. Optimization Methods and Software 2003;

18(1):81-104.

14. Yatsenko V, Carney P, Pardalos P, Sackellares JC, Shiau DS. Control of chaotic systems: a

practical application to epilepsy, Proc. of Second International Conference on Control

Problems, Moscow, Institute of Control Problems. 2003; 205-218.

15. Yatsenko V, Sackellares C, Pardalos P, Carney P. Geometric models, fiber bundles and

biomedical applications. Fifth International Conference: Symmetry in Nonlinear

Mathematical Physics, Institute of Mathematics. Kiev, 2003; 195-217.

16. Iasemidis LD, Shiau DS, Chaovalitwongse W, Sackellares JC, Pardalos PM, Principe JC,

Carney PR, Prasad A, Veeramani B, Tsakalis K. Adaptive epileptic seizure prediction

system. IEEE Trans Biomed Eng. 2003 May; 50(5):616-27.

17. Becker DA, Fennell, EB, Carney PR. Sleep disturbance in children with epilepsy. Epilepsy

Behav. 2003; 4(6):651-8.

18. Stickler DE, Carney PR, Valenstein ER. Juvenile-onset Leigh syndrome with an acute

polyneuropathy at presentation. Child Neurol. 2003; 18(8):574-6.

19. Becker DA, Fennell EB, Carney PR. Daytime behavior and sleep disturbance in childhood

epilepsy. Epilepsy Behav 2004; 5: 708-15.

20. Sackellares JC, Iasemidis LD, Shiau LD, Pardalos PM, Carney PR. Spatiotemporal

transitions in temporal lobe epilepsy. Quantitative Neuroscience: Models, Algorithms,

Diagnostics, and Therapeutic Applications. Kluver Academic Publishers 2004; 223-38.

21. Shiau DS, Chaovalitwongse W, Iasemidis LD, Pardalos PM, Carney PR, Sackellares JC.

Nonlinear dynamical and statistical approaches to investigate dynamical transitions before

epileptic seizures. Quantitative Neuroscience: Models, Algorithms, Diagnostics, and

Therapeutic Applications. Kluver Academic Publishers 2004; 239-50.

22. Yang MCK, Shiau DS, Sackellares JC, Carney PR. Testing whether a prediction scheme is

better than guess, In: Pardalos PM, Sackellares JC, Carney PR, and Iasemidis LD (eds.)

Quantitative Neuroscience, Kluver Academic Publishers 2004; 251-259.

23. Carney PR, Shiau DS,

Pardalos PM, Iasemidis LD, Chaovalitwongse W, Sackellares JC.

Nonlinear neurodynamical features in an animal model of generalized epilepsy. Quantitative

Neuroscience: Models, Algorithms, Diagnostics,and Therapeutic Applications. Kluver

Academic Publishers, 2004, 37-52.

24. Pardalos PM, Chaovalitwongse W, Iasemidis LD, Sackellares JC, Shiau DS, Carney PR,

Prokopyev OA, Yatsenko VA. Seizure warning algorithm based on optimization and

nonlinear dynamics. Math. Program Ser B, 35-50: 2004.

25. Pardalos PM, Boginski VL, Prokopyev OA, Suharitdamrong W, Carney PR,

Chaovalitwongse W, Vazacopoulos A. Optimization Techniques in Medicine. In: Eds. Audet

C, Hansen P, Savard G. Essays and Surveys in Global Optimization. Springer, 2005; 151-

173.

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26. Sanchez JC, Principe JC, Carney PR. Is neuron discrimination preprocessing necessary for

linear and nonlinear brain machine interface models? 11th International Conference on

Human-Computer Interaction, 2005; 1100-1115.

27. Iasemidis LD, Shiau DS, Pardalos PM, Chaovalitwongse W, Narayanan K, Prasad A,

Tsakalis K, Carney PR, Sackellares JC. Long-term prospective on-line real-time seizure

prediction. Clin Neurophysiol. 2005 Mar; 116(3):532-44. Epub 2005 Jan 6.

28. Chaovalitwongse W, Iasemidis LD, Pardalos PM, Shiau DS, Sackellares JC, Carney PR.

Performance of a seizure warning algorithm based on the dynamics of intracranial EEG.

Epilepsy Res. 2005 May; 64(3):93-113. William Pierskalla Best Paper Award, Institute for

Operations Research and the Management Sciences.

29. Dharnidharka VR and Carney PR. Isolated idiopathic hypomagnesemia presenting as

aphasia and seizures. Pediatr Neurol. 2005 Jul; 33(1):61-5.

30. Shiau DS, Nair SP, Iasemidis LD, Norman

W, Principe JC, Pardalos PM, Suharitdamrong

W,

Cho J, Sackellares JC, Carney PR. Seizure warning and dynamic response to electrical

stimulation in a rodent model of chronic limbic epilepsy. IEEE Engineering in Medicine and

Biology. 2005; 95-100.

31. Iasemidis LD, Shiau DS, Pardalos PM, Chaovalitwongse W, Narayanan K, Prasad A,

Tsakalis K, Sackellares JC, Carney PR. Long-term prospective on-line real-time seizure

prediction. Clinical Neurophysiol. 2005; 116 (3): 532-544.

32. Chaovalitwongse W, Pardalos PM, Iasemidis LD, Carney PR, Shiau DS, Suharitdamrong

W, Sackellares JC. A robust method for studying the dynamics of the intracranial EEG:

Application to epilepsy. Epilepsy Res 2005; 64: 93-113.

33. Shiau DS, Nair SP, Iasemidis LD, Carney PR, Norman WM, Principe JC, Pardalos PM,

Suharitdamrong W, Cho J, Sackellares JC. Seizure warning and dynamic response to

electrical stimulation in a rodent model of chronic limbic epilepsy. Proceedings of 3rd

European Medical and Biological Conference, Prague, Czech Republic: Vol. 11, 2005.

34. Pardalos PM, Sackellares JC, Carney PR, Iasemidis LD. Quantitative Neuroscience:

Models, Algorithms, Diagnostics, and Therapeutic Applications. Kluver Academic

Publishers, Norwell, MA 2004.

35. Nair S, Sackellares JC, Shiau DS, Norman W, Dance L, Pardalos P, Principe JP, Carney

PR. Effects of acute hippocampal stimulation on EEG dynamics. IEEE Med Biol. 2006;1:

4382-6.

36. Mishra M, Jones

B, Simonotto

JD, Furman

MD, Norman

W, Liu

Z, DeMarse

TB, Carney

PR, Ditto WL. Pre-ictal correlation and entropy analysis of microwire data from an animal

model of limbic epilepsy. IEEE Eng Med Biol. 2006;1: 1605-7.

37. Chaovalitwongse WA, Iasemidis LD, Pardalos PM, Carney PR, Shiau DS, Sackellares JC.

Reply to comments on Performance of a seizure warning algorithm based on the dynamics of

intracranial EEG by Mormann, F., Elger, C.E., and Lehnertz, K, Epilepsy Res. 2006

Oct;71(2-3):241-2.

38. Simonotto JD, Myers

SM, Furman

MD, Norman

WM, Liu

Z, DeMarse TB, Ditto WL,

Carney PR. Coherence analyses over the latent period of epileptogenesis reveal that high-

frequency communication is increased across hemispheres in an animal model of limbic

epilepsy. IEEE Eng Med Biol. 2006; 1:1154-6.

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39. Nelson R, Myers

S, Simonotto

J, Furman

M, Spano

M, Norman

W, Liu

Z, DeMarse T,

Ditto W, Carney PR. Detection of high frequency oscillations with teager energy in an

animal model of limbic epilepsy. IEEE Eng Med Biol Soc. 2006;1: 2578-80.

40. Sanchez JC, Carney PR, Principe JC. Analysis of amplitude modulated control features for

ecog neuroprosthestics. IEEE Eng Med Biol. 2006;1: 5468-71.

41. Qizhi Z, Liu Z, Carney PR, Jiang H. Imaging epilepsy using finite element-based

photoacoustic tomography: initial in vivo results. Biomedical Optics Tech Digest ME18;

2006

42. Geyer JD, Carney PR, Gilliam F. Focal epileptiform spikes in conjunction with k-

complexes. J Clin Neurophysiol. 2006 Oct; 23(5):437-440.

43. Sanchez JC, Mareci T, Norman W, Principe J, Ditto W, and Carney PR. Evolving into

epilepsy: Multiscale electrophysiological analysis and imaging in an animal model. Exp

Neurol. 2006 Mar; 198(1): 31-47.

44. Nair SP, Shiau DS, Iasemidis LD, Norman WM, Pardalos PM, Sackellares CS, Carney PR.

Seizure predictability in an experimental model of epilepsy. Proc Quant Neurosci Conf.

2006; 213-220.

45. Stickler DE, Valenstein E, Neiberger RE, Perkins LA, Carney PR, Shuster JJ, Theriaque

DW, Stacpoole PW. Peripheral neuropathy in genetic mitochondrial diseases. Pediatr

Neurol. 2006 Feb; 34(2):127-31.

46. Miller J, Carney P. Central hypothyroidism with oxcarbazepine therapy. Pediatr Neurol.

2006 Mar; 34(3): 242-4.

47. Stacpoole PW, Kerr DS, Barnes C, Bunch ST, Carney PR, Fennell E, Felitsyn NM,

Gilmore R, Greer M, Henderson G, Hutson AD, Neiberger R, O’Brien R, Perkins LA,

Quisling R, Shroads AL, Shuster JJ, Silverstein JH, Theriaque DW, Valenstein E. A

controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in

children. Pediatrics 2006 May; 117(5):1519-1531.

48. Sanchez JC, Alba N, Nishida T, Batich C, Carney PR. Structural modifications in chronic

microwire electrodes for cortical neuroprosthetics. IEEE TNSRE 2006;14(2): 217-221.

49. Chaovalitwongse WA, Iasemidis LD, Pardalos PM, Carney PR, Shiau DS, Sackellares JC.

Reply to comments on Performance of a seizure warning algorithm based on the dynamics of

intracranial EEG by Mormann, F., Elger, C.E., and Lehnertz, K. Epilepsy Res. 2006 Nov;

72(1):85-7.

50. Chaovalitwongse W, Pardalos PM, Iasemidis LD, Suharitdamrong DS, Dance LK, Prokopyev

OA, Boginski VL, Carney PR, Sackellares JC. Data mining in EEG: applications to epileptic

brain disorders. In: Data Mining in Biomedicine. Series: Springer Optimization and its

Applications, Pardalos, Panos M. Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:459:

2007.

51. Shaiu DS, Iasemidis LD, Yang MCK, Pardalos PM, Carney PR, Dance LD,

Chaovalitwongse W, Sackellares JC. Automated seizure prediction algorithm and its

statistical assessment: a report from ten patients. In: Data Mining in Biomedicine. Series:

Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L;

Vazacopoulos, Alkis (Eds.), 7:517:2007.

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52. Nair SP, Shiau DS, Iasemidis LD, Norman WM, Pardalos PM, Sackellares JC, Carney PR.

Seizure predictability in an experimental model of epilepsy. In: Data Mining in Biomedicine.

Series: Springer Optimization and its Applications, Pardalos, Panos M. Boginski, Vladimir L;

Vazacopoulos, Alkis (Eds.), 7:535:2007.

53. Prokopyev OA, Boginski VL, Chaovalitsongse W, Pardalos PM, Sackellares JC, Carney PR.

Network-based techniques in EEG data analysis and epileptic modeling. In: Data Mining in

Biomedicine. Series: Springer Optimization and its Applications, Pardalos, Panos M.

Boginski, Vladimir L; Vazacopoulos, Alkis (Eds.), 7:559:2007.

54. Hwang Dong-UK, Talathi S, Carney PR, Ditto W, Myers S, Norman W, Simonotto J. High

frequency oscillations in the limbic rat model of temporal lobe epilepsy. Computational

Neuroscience, 2007.

55. Martynyuk AE, Ucar DA,

Yang DD, Norman WM, Carney PR, Dennis DM, Laipis PJ.

Epilepsy in phenylketonuria: A complex dependence on serum phenylalanine levels.

Epilepsia. 2007 Jun; 48(6):1143-50.

56. Jian B, Vemuri BC, Ozarslan E, Carney P, Mareci T. A novel tensor distribution model for

the diffusion weighted MR signal. Neuroimage. 2007 Aug 1;37 (1):164-76.

57. Ramirez-Manzanares A, Rivera M, Vemuri BC, Carney P, Mareci T. Diffusion basis

functions decomposition for estimating white matter intra-voxel fiber geometry. IEEE

Transactions on Medical Imaging, 2007; 26:1091-1102.

58. Talathi SS, Hwang DU, Ditto W, Carney PR. Early seizure detection in an animal model of

temporal lobe epilepsy, Data Mining, Systems Analysis and Optimization in Biomedicine,

AIP Conf Proc, 2007; 953:292-307.

59. Sanchez JC, Gunduz A, Carney PR, Principe JC. Extraction and localization of mesoscopic

motor control signals for human ECoG neuroprosthetics. J Neurosci Methods. 2008;167

(1):63-81.

60. Wang Q, Liang X, Liu Z, Zhang Q, Carney PR, Jiang

H. Visualizing localized dynamic

changes during epileptic seizure onset in vivo with diffuse optical tomography. Med Phys.

2008;1: 216-224.

61. Zhang Q, Liu Z, Carney PR, Yuan Z, Chen X. Roper SN, Jiang H. Noninvasive imaging of

epileptic seizures in vivo using photoacoustic tomography. Phys. Med. Biol. 2008 53:1921-

1931.

62. Talathi SS, Hwang DU, Ditto WL, Spano M, Myers SM, Winters, J, Simonotto J, Carney

PR. Non-parametric early seizure detection in an animal model of temporal lobe epilepsy. J

Neural Eng. 2008 Mar; 5 (1):85-98.

63. Carney PR, Cadotte A, DeMarse TB, Vemuri B, Mareci T. Ditto W. Effective and

anatomical connectivity in a rat model of spontaneous limbic seizures. In: Seizure Prediction

in Epilepsy: From Basic Mechanisms to Clinical Application. Wiley Vch Verlag GmbH &

Co. KGaAA, Schelter B, Timmer J, Schultze-Bonhage A, Eds, 45-59, 2008.

64. Stacpoole PW, Gilbert LR, Neiberger RE, Carney PR, Valenstein E, Theriaque DW,

ShusterJJ. Evaluation of long-term treatment of children with congenital lactic acidosis with

dichloroacetate. Pediatrics. 2008 May;121(5):e1223-8.

65. Geyer JD, Carney PR, Dillard SC, Davis L, Ward LC. Antidepressant medications,

neuroleptics and prominent eye movements during NREM Sleep. J Clin Neurophysiol. 2009

Feb; 26(1):39-44.

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66. Nair SP, Shiau DS, Principe JC, Iasemidis LD, Pardalos PM, Norman WM, Kelly KM,

Sackellares JC, Carney PR. An investigation of EEG dynamics in an animal model of

temporal lobe epilepsy using the maximum Lyapunov exponent. Exp Neurol. 2009 Mar;

216(1):115-21.

67. Talathi SS, Hwang DU, Ditto WL, Mareci T, Sepulveda H, Carney PR. Circadian control of

neural excitability in an animal model of temporal lobe epilepsy. Neurosci Lett. 2009 May

15; 455(2):145-9.

68. Komalapriya C, Romano MC, Thiel M, Schwarz U, Kurths J, Simonotto J, Furman M, Ditto

WL, Carney PR. Predictability of spontaneous limbic seizures using recurrence measures.

Int. J. Bifurcation and Chaos, 19 (2) 605-617, 2009.

69. Cadotte A, Mareci T, DeMarse T, Prarekh M, Rajagovindan R, Ditto W, Talathi S, Hwang

DU, Carney PR. Temporal lobe epilepsy: anatomical and effective connectivity. IEEE

Trans Neural Syst Rehabil Eng. 2009 Jun; 17 (3):214-23.

70. Gunduz A, Sanchez JC, Carney PR, Principe JC. Mapping broadband electrocorticographic

motor control features to two-dimensional hand trajectories in humans motor control features.

Neural Netw. 2009 Nov;22(9):1257-70

71. Talathi SS, Hwang DU, Miliotis A, Carney PR, Ditto WL. Predicting synchrony in

heterogeneous pulse coupled oscillators. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug;

80(2 Pt 1):021908.

72. Saxonhouse M, Tarquinio D, Carney P, Bennett J, Smith A, Hunger S, Geyer J. Low

molecular weight heparin use in a case of noncardiogenic multifocal perinatal

thromboembolic stroke. Adv Hematol. 2009:153643.

73. Kumar R, Vemuri BC, Wang F, Syeda-Mahmood T, Carney PR, Mareci TH. Multi-fiber

reconstruction from DW-MRI using a continuous mixture of hyperspherical von Mises-

Fisher distributions. Inf Process Med Imaging. 2009; 21:139-50.

74. Talathi, SS, Hwang D, Carney, PR, Ditto W. Synchrony with shunting inhibition in a

feedforward inhibitory network. J Comput Neurosci. 2010 Apr; 28(2):305-21.

75. Astary GW, Kantorovich S, Carney

PR, and Mareci

TH, Malisa Sarntinoranont

M. Regional

convection enhanced delivery of gadolinium labeled albumin into the rat hippocampus in

vivo. J Neurosci Methods. 2010 Mar 15;187 (1):129-37.

76. Cadotte AJ, DeMarse TB, Mareci TH, Parekh M, Talathi SS, Hwang DU, Ditto WL, Ding M,

Carney PR. Granger causality relationships between local field potentials in an animal

model of temporal lobe epilepsy. J Neurosci Methods. 2010 May 30;189(1):121-9.

77. Fisher N, Talathi SS, Carney PR, Ditto WL. Effects on homeostatic spike rate. Biol Cybern.

2010 May; 102(5):427-40.

78. Nandan M, Talathi SS, Myers S, Ditto WL, Khargonekar PP, Carney PR. Support vector

machine algorithms for seizure detection in an animal model of chronic epilepsy. J Neural

Eng. 2010 Jun;7(3):036001.

79. Parekh MB, Carney PR, Sepulveda H, Norman W, King M, Mareci TH. Early MR Diffusion

and Relaxation Changes in the Parahippocampal Gyrus Precede the Onset of Spontaneous

Seizures in an Animal Model of Chronic Limbic Epilepsy. Exp Neurol. 2010 Apr 12; 224

(1):258-270.

80. Talathi SS, Carney PR, Khargonekar PP, Control of neural synchrony using

channelrhodopsin-2: A computational study, J Comput Neurosci. 2010 Dec 21.

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Under Review

1. Tarquinio D, Smith A, Bennett J, Carney PR, Hunger SP, and Saxonhouse MA. A severe

case of multi-focal cerebral infarction in a full-term neonate: is anticoagulation necessary?

Pediatric Neurology.

2. Gunduz A, Sanchez JC, Carney PR, Principe JC. Deciphering two-dimensional hand

trajectories from broadband ecog in humans. IEEE TNSRE.

3. Gunduz A, Sanchez JC, Carney PR, Principe JC. Analysis of movement-related features in

broadband human electrocorticography for deciphering two-dimensional hand trajectories. J

Neurosci Methods.

4. Geyer JD, Lichstein KL, Ruiter ME, Carney PR, Dillard SC. Paradoxical insomnia and

cognitive intervention. J Clinical Sleep Medicine.

5. Geyer JD, Lichstein KL, Ruiter ME, Ward LC, Carney PR, Dillard SC. Sleep education for

paradoxical insomnia. J Behavioral Sleep Medicine.

6. Goodmon K, Gulati S, Jones

LL, Concepcion

L, Liu Z MD, Andrade E, Carney PR, Borum

PR. AED Medication Score: A Tool to Assess the Efficacy of Ketogenic Therapy. Pediatric

Neuology.

7. Carney PR, Talathi SS, Hwang DU, Ditto W. Circadian Regulation of Neural Excitability

in Temporal Lobe Epilepsy. Chapter 19, Ed: Osorio I. International Seizure Prediction

Conference Proceedings, 2010.

In preparation

1. J. H. Kim, G. Astary, S. Kantorovich, T. H. Mareci, P. Carney, M. Sarntinoranont.

Computational Model and In Vivo MR Experiments for Convection Enhanced Delivery in the

Rat Ventral Hippocampus.

2. J. H. Kim, G. Astary, T. L. Nobrega, T. H. Mareci, P. Carney, M. Sarntinoranont. Dynamic

Contrast-Enhanced MRI of Gd-albumin Delivery to the Rat Hippocampus In Vivo by

Convection-Enhanced Delivery.

Textbooks

1. James D. Geyer, Paul R. Carney, Troy T. Payne, Michael Aldrich. Atlas of Digital

Polysomnography. 1st ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2000.

2. Paul R. Carney, James D. Geyer, Richard Berry, eds. Clinical Sleep Disorders, 1st ed.

Lippincott Williams & Wilkins, Inc., Philadelphia, 2005.

3. James D. Geyer, Janice M. Keating, Daniel C. Potts, Paul R. Carney. Neurology for the

Boards, 3rd

ed. Lippincott-Williams & Wilkins, Inc., Philadelphia, 2006.

4. James D. Geyer, Daniel C. Potts, Edward E. Marsh, Paul R. Carney. Neurology for Wards

and Mini-Boards: The Complete Medical Student Guide. 1st ed. Lippincott-Williams &

Wilkins, Inc., Philadelphia 2009.

5. Paul R. Carney and James D. Geyer JD. Pediatric Practice: Neurology, McGraw Hill

Professional Pubs, 1st edition. 2009.

6. L. John Greenfield, James D. Geyer, Paul R. Carney. Reading EEGs: A Practical

Approach. 1st ed. Lippincott-Williams & Wilkins, Inc., Philadelphia 2009.

7. James D. Geyer, Paul R. Carney, Troy T. Payne. Atlas of Digital Polysomnography. 2nd

ed.

Lippincott-Williams & Wilkins, Inc., Philadelphia, 2009.

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Textbooks under preparation

1. Paul R. Carney, James D. Geyer, Richard Berry, eds. Clinical Sleep Disorders, 2nd

ed.

Lippincott-Williams & Wilkins, Inc., Philadelphia, 2011.

2. Paul R. Carney and James D. Geyer. Clinical Neurophysiology: Methods and Clinical

Applications. CRC Press. 2011.

Monographs and Book Chapters

1. Becker DA, Bongiolatti SR, Carney PR. (2005). Sleep questionnaires. In: Carney PR,

Geyer JD, Berry R, eds. Clinical Sleep Disorders, 1st ed. Philadelphia: Lippincott Williams

& Wilkins 2005; 479-481.

2. Carney PR, Becker DA, Bongiolatti S. (2005) Ontogeny of Sleep. In: Carney PR, Geyer

JD, Berry R, eds. Clinical Sleep Disorders, 1st ed. Philadelphia: Lippincott Williams &

Wilkins 2005; 95-98.

3. Becker D, Carney PR. Pediatric and adolescent presentations. In: Carney PR, Geyer JD,

Berry R, eds. Clinical Sleep Disorders, 1st ed. Philadelphia: Lippincott Williams & Wilkins

2005; 136-146.

4. Berry R, Geyer JD, Carney PR. Introduction to sleep medicine. In: Carney PR, Geyer JD,

Berry R, eds. Clinical Sleep Disorders, 1st ed. Philadelphia: Lippincott Williams & Wilkins:

2005; 3-28.

5. Becker D, Bongiolatti S, Carney PR. Sleep questionnaires. In: Carney PR, Geyer JD, Berry

R, eds. Clinical Sleep Disorders, 1st ed. Philadelphia: Lippincott Williams & Wilkins 2005;

479-481.

6. Ringdahl D, Snively C, Carney PR. Pharmacological treatments. In: Carney PR, Geyer JD,

Berry R, eds. Clinical Sleep Disorders, 1st ed. Philadelphia: Lippincott Williams & Wilkins

2005; 484-487.

Geyer JD, Carney PR, Dillard SC, Tsikhlakis JC. Sleep and Vascular Disorders. In:

Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters

Kluwer, Lippincott Williams & Wilkins, Phil. 2009:100-106.

7. Carney PR, Geyer JD, Saxonhouse MA, Gomez CR, Malaty I. Pediatric Stroke. In:

Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters

Kluwer, Lippincott Williams & Wilkins, Phil. 2009:130-140.

8. Geyer JD, Carney PR, Lichstein K, Dillard SC, Henderson MM. Sleep and Acute Stroke.In:

Stroke: A Practical Approach. Edited by James D. Geyer and Camilo R. Gomez, Wolters

Kluwer, Lippincott Williams & Wilkins, Phil. 2009:301-307.

9. Fisher N, Talathi S, Cadotte A,

Meyers, S, Carney PR

Epilepsy Detection and

Monitoring, In: Quantitative EEG Analysis Methods and the Application. Eds: Shanbao

Tong and Nitish V. Thakor, Artech House, Inc., of Norwood, MA, USA, pp 141-167, 2009.

10. Carney PR, Fisher N,

Ditto, WL. Geyer JD. Quantitative Sleep Monitoring. In:

Quantitative EEG Analysis Methods and the Application. Editors: Shanbao Tong and Nitish

V. Thakor, Artech House, Inc., of Norwood, MA, USA, pages 257-288, 2009.

11. Carney PR. Geyer JD, Tinuper P. Bisulli F, Provini F. Treating Epilepsy in the Presenceof

Sleep Disorders. Chapter 34, In: Medical and Surgical Treatment of Pediatric Epilepsy. Eds:

Helen Cross, Michael Duchowny, Tracy Glauser, Edouard Hirsch, Alexis Arzimanoglou.

McGraw-Hill Pubs, 2009.

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12. Carney PR. Alterations of Consciousness New Patient. In: Child Neurology Telephone

Encounter Guides. Eds. Sprague-McRae, J, Rosenblum R, Morrison L. Association of Child

Neurology Nurses, 1st Ed., 2009.

13. Philip Barish, Svetlana Kantorovich, Paul R. Carney, William Ogle. Decoding Neural

Circuitry with Optogenetics: Applications for Epilepsy. From the Hallowed Halls of Herpes

virology – A Tribute to Bernard Roizman. Eds.: John A. Blaho and Joel D. Baines, Editors

World Scientific Publishing / Imperial College Press, 2010.

14. Carney PR, Talathi SS, Geyer JD. Pediatric Sleep Issues. Chapter 21, Sleep Medicine

Updates, Ed. Octavian Ioachimescu, 1st edition, Bentham Publishing, E-Book, In Press.

Peer- Reviewed Conference Proceedings and Meeting Abstracts

1. Carney PR, Silver J. A mechanism for the guidance of peripheral spiral ganglion cell axons

in the developing mouse auditory system. Soc. Neurosci. XVI, 1980; 6:487.

2. Carney PR, Silver J, Manubens L. Cell migration and axon guidance in the developing rat

auditory system. 3 rd Reg. Chile Biol. Soc. 1983; 4:10.

3. Carney PR, Couve E. Cell polarity changes and migration during early development of the

avian peripheral auditory system Fourth International Congress of Cell Biology (Montreal).

1988; 7.2.28.

4. Larson W, Carney P, Aldrich M. Atypical presentation of Leigh disease in a teenage

woman. Mitochondrial Diseases Symposium. Indianapolis, Ind., 1995.

5. Payne T, Kothary S, Varma N, Nasreddine W, Carney P, Shu V, Beydoun A. Serum

sodium and thyroid function after replacement of carbamazepine with oxcarbazepine.

Epilepsia 1997; 3.023.

6. Carney P, Nasreddine W, Drury I, Varma N, Payne T, Shu V, Beydoun A. The

relationship between thrombocytopenia and valproate dose. Epilepsia 1997; 3.054.

7. Carney PR, Blaivas M, Drury I. Histopathological findings in a familial form of medically

refractory temporal lobe epilepsy. Epilepsia 1998.

8. Herrmann DN, Carney PR, Wald JJ. Juvenile myasthenia gravis: treatment with immune

globulin and thymectomy. Pediatr Neurol. 1998; 18:63-66.

9. Tran TX, Palmer SC, Ni OK, Muir AB, Carney PR. Epilepsia partialis continua as a

presenting manifestation of diabetic ketoacidosis. Ann Neurol. 1999; 46: 96.

10. Muir A, Carney PR. Epilepsia partialis in a ketoacidotic child. Ann Neurol. 1999;

46:96.Tran TX, Palmer SC, Ni O, Iasemidis LD, Pardalos PM, Srivastava A, Won J, Shiau

DS,Lee N, MacLennan AJ, Sackellares JC, Carney PR. Predictability of seizures in an

epilepsy-prone transgenic mouse model, Epilepsia 2001; 42 (7): 225.

11. Saxonhouse MA, Bhatti MT, Driebe WT, Freeman BE, Maria BL, Carney PR. Primary

antiphospholipid syndrome presenting with a branch retinal artery occlusion in a 15-year-old

boy. J Child Neurol. 2002; 17(5):392-4.

12. Sackellares JC, Shiau DS, Iasemidis L, Pardalos P, Chaovalitwongse W, Carney PR. Can

knowledge of cortical cite dynamics in a preceding seizure be used to improve prediction of

the next seizure? Annals Neurol. 2002; 52 (3S), S65-S66.

13. Carney PR, Maze MF, Shiau DS, Srivastiva A, Iasemidis LD, Pardalos PM, Sackellares,

JC. State-specific nonlinear neurodynamic features in an animal model of generalized

epilepsy. Epilepsia 43 Suppl. 7 :270 (Abst. 3.063 ) , 2002.

14. Shiau DS, Sackellares JC, Iasemidis LD, Maze MF, Carney PR. Nonlinear Approximate

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Entropy Analysis of Brain Electrical Activity in a Generalized Epilepsy Animal Model.

Epilepsia 2002; 443 (7): 273.

15. Sackellares JC, Iasemidis LD, Shiau DS, Chaovalitwongse W, Pardalos P, Carney PR.

Dynamical Dependence of Seizure Prediction on Preceding Seizures. Epilepsia 43 Suppl.

7 :50 (Abst.1.136), 2002

16. Iasemidis LD, Shiau, DS, Chaovalitwongse W, Pardalos PM, Carney PR, Sackellares

JC. Adaptive Seizure Prediction System. Epilepsia 43 Suppl. 7:264 (Abst. 3.048 ), 2002.

17. Chaovalitwongse W, Iasemidis LD, Prasad A, Shiau, DS, Pardalos PM, Carney PR,

Sackellares JC. Seizure Prediction by Dynamical Phase Information from the EEG.

Epilepsia 43 Suppl. 7 :45 (Abst.1.121), 2002.

18. Snively C, McClernan CS, Maze MF, Carney PR. Efficacy and tolerability of the

ketogenic diet in the very young. Epilepsia 43 Suppl. 7:225 (Abst. 2.281), 2002.

19. Sackellares JC, Shiau DS, Iasemidis LD, Pardalos PM, Chaovalitwongse W, Carney

PR,Can knowledge of cortical site dynamics in a preceding seizure be used to improve

prediction of the next seizure? Ann Neurol. 2002; 52, (3S), S65-S66.

20. Chaovalitwongse W, Iasemidis LD, Prasad A, Shiau DS, Pardalos, PM, Carney PR,

Sackellares JC. Seizure prediction by dynamic phase information from the EEG.

Epilepsia 2002; 443(7):45.

21. Sackellares JC, Iasemidis LD, Shiau D-S, Chaovalitwongse W, Pardalos PM, Carney

PR. Dynamic dependence of seizure prediction on preceding seizures. Epilepsia 43

Suppl. 7:50 (Abst. 1.136) , 2002.

22. Iasemidis LD, Shiau D-S, Chaovalitwongse W, Pardalos PM, Carney PR, Sackellares

JC. Adaptive seizure-prediction system. Epilepsia 2002, 443(7): 264.

23. Carney PR, Maze MF, Shiau DS, Srivastiva A, Iasemidis LD, Pardalos PM, Sackellares,

JC. State-specific nonlinear neurodynamic features in an animal model of generalized

epilepsy. Epilepsia 2002; 443(7):270.

24. Shiau DS, Sackellares JC, Iasemidis LD, Maze MF, Carney PR. Nonlinear approximate

entropy analysis of brain electrical activity in a generalized epilepsy animal model.

Epilepsia 2002; 443(7):273.

25. Shiau DS, Iasemidis LD, Sackellares JC, Pardalos PM, Carney PR, Chaovalitwongse W.

Nonlinear Dynamics and Global Optimization Approaches to Investigate Dynamical

Transitions Before and After Epileptic Seizures. Quantitative Neurosciences Conference

at University of Florida, February 5-7, 2003.

26. Sackellares JC, Iasemidis LD, Shiau DS, Carney PR, Pardalos PM, Chaowalitwongse

W, Preictal Transition in Temporal Lobe Epilepsy. Quantitative Neurosciences

Conference at University of Florida, February 5-7, 2003.

27. Carney PR, Iasemidis LD, Sackellares JC, Srivastava A, Shiau DS, Maze MF, Zhang L,

MacLennan AJ, Pardalos PM. Seizure Prediction by Nonlinear Times Series Analyses of

Brain Electrical Activity in the H218 Animal Model. Quantitative Neurosciences

Conference at University of Florida, February 5-7, 2003.

28. Iasemidis LD, Sackellares JC, Pardalos PM, Shiau DS, Chaovalitwongse W, Carney PR.

Epileptic Seizure Prediction. Quantitative Neurosciences Conference at University of

Florida, February 5-7, 2003.

29. Chaovalitwongse W, Pardalos PM, Sackellares JC, Iasemidis LD, Shiau DS, Carney PR.

Nonlinear Dynamics and Global Optimization in EEG with Applications for Prediction of

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Epileptic Seizures. Quantitative Neurosciences Conference at University of Florida,

February 5-7, 2003.

30. Sackellares JC, Shiau DS, Pardalos PM, Carney PR, Chaowalitwongse W. Time

Irreversibility of Brain Spatio-Temporal Dynamics at Epileptic Seizure Transitions.

International Nonlinear Sciences Conference, Vienna, Austria, February 7-9, 2003.

31. Sackellares JC, Yang MCK, Iasemidis LD, Shiau DS, Pardalos PM, Carney PR. Real –

Time Prospective Seizure Prediction and Statistical Assessment. NIH Biomedical

Information Science Technology InitiativeConsortium BISTIC, Bethesda, MD, Nov 6-7,

2003.

32. Shiau DS, Sackellares JC, Iasemidis LD, Carney PR, Pardalos PM, Chaovalitwongse W.

Dynamical Entrainment Among Epileptic Brain Areas, Ann Neurol. 2003; 54 (S7: S55).

33. Sackellares JC, Iasemidis LD, Shiau DS, Suharitdamrong W, Dance LK,

Chaovalitwongse W, Pardalos PM, Carney PR. An Automated Seizure Warning

Algorithm for Scalp EEG. Epilepsia 2003; 44 (9), 228.

34. Carney PR, Sackellares JC, Shiau DS, Iasemidis LD, Chaovalitwongse W,

Suharitdamrong W, Pardalos PM. Detection of Seizures in Newborns by Quantitative

EEG Signal Analyses. Epilepsia 2003; 44 (9) 54-55.

35. Sackellares JC, Yang MCK, Shiau DS, Iasemidis LD, Pardalos PM, Carney PR.

Prospective controlled trial of an automatic seizure prediction algorithm. . American

Academy of Neurology 55th

Annual Meeting, 2003. Neurology 60 Suppl. 1, Number 5,

2003.

36. Carney PR, Nair SP, Iasemidis LD, Shiau DS, Pardalos PM, Shenk D, Norman WM,

Sackellares JC. Quantitative analysis of EEG in the rat limbic epilepsy model. American

Academy of Neurology 56th

Annual Meeting, San Francisco, April 24-May 1, Poster

P04.016, 2004.

37. Sackellares JC, Iasemidis LD, Shiau DS, Yang CK, Dance LD, Pardalos PM, Carney

PR. Automated seizure warning system performance in temporal lobe epilepsy.

American Academy of Neurology, 56th

Annual Meeting, San Francisco, April 24-May 1,

Poster P02.033, 2004.

38. Nair SP, Shiau DS, Norman WN, Shenk D, Suharitdamrong W, Iasemidis LD, Pardalos

PM, Sackellares JC, Carney PR. Dynamical changes in the rat chronic limbic epilepsy

model. Epilepsia 45 Suppl. 7:211 (Abst. 2.060 ) , 2004.

39. Shiau DS, Iasemidis LD, Yang MCK, Carney PR, Pardalos PM, Suharitdamrong W,

Nair SP, Sackellares JC. Pattern-match regularity statistics-a measure quantifying the

characteristics of epileptic seizures. Epilepsia 45 Suppl. 7 :85 (Abst. 1.213 ) , 2004.

40. Furman, Michael; Sackellares, J. Chris; Carney, Paul; Miliotis, Abraham;

Simonotto, Jennifer; Ditto, William Phase Tracking of Moving Epileptic Foci Using EEG

and Phase-Dynamic Quantification Analysis. American Physical Society, March Meeting

2004, March 22-26, 2004, Palais des Congres de Montreal, Montreal, Quebec, Canada,

MEETING ID: MAR04, abstract #V8.008

41. Shiau DS, Sackellares JC, Iasemidis LD, Nair SP, Norman W, Carney PR. Automated

Seizure Warning in an Epileptic Rat Model. 57th Annual Meeting of the American

Academy of Neurology, Miami Fl, April, 2005. Neurology 64 Suppl. 1 (Abst. A:266),

2005.

42. Stickler DE, Valenstein E, Neiberger RE, Perkins LA, Carney PR, Shuster JJ, Theriaque

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DW, Stacpoole PW. Peripheral neuropathy in genetic mitochondrial diseases. Muscle

and Nerve, 57th Annual Meeting of the American Academy of Neurology, April, 2005,

43. Shaiu DS, Iasemidis LD, Sackellares JC, Suharitdamrong W, Shenk D, Carney PR.

Quantitative methods for distinguishing neonates at risk for seizures from normal

newborns. PAS 2005: 57: 2655.

44. Furman M, Ditto W, Simmonoto J, Carney PR. High-Resolution Phase Tracking of

Moving Epileptic Foci with Phase-Dynamic Quantification Analysis. Epilepsia 46 Suppl.

8:314 (Abst. 3.113) , 2005.

45. Liu Z, Norman W, Shenk D, Carney PR, Similarity of electroencephalographic changes

in a rat model of human temporal lobe epilepsy. Epilepsia 2005; 46 (8): 292.

46. Bongiolatti S, Fennell E, Carney PR. Sleepiness as a Factor in Varying Degrees of

Behavior Problems in Children with Epilepsy. Epilepsia 46 Suppl. 8:75 (Abst. 1.176)

2005.

47. Simmonoto J, Furman, Norman W, Sanchez J, Ditto W, Carney PR. Nonlinear Analysis

of High-Resolution Microwire Electrode Data from a Chronic Limbic Epilepsy Model

over the Latent Period. Epilepsia 46 Suppl. 8:124(Abst.2.098), 2005.

48. Nair S, Shaiu D, Pardalos PD, Iasemidis L, Sackellares JC, Carney PR. Dynamical

Responses to Hippocampal Stimulation in a Rodent Model of Chronic Limbic Epilepsy.

Epilepsia 46 Suppl. 8:332 Abst. 3.163, 2005.

49. Sanchez J, Norman W, Mareci T, Carney PR. Multiscale Electrophysiological analysis

and imaging in an animal model of limbic epilepsy. Epilepsia 46 Suppl. 8:10, 2005.

50. Geyer JD, Carney PR, Gilliam F. Focal Dyshormia: Focal epileptiform spikes in

conjunction with K-complexes. Epilepsia 46 Suppl. 8:27 (Abst. 1.041), 2005.

51. Shiau DS, Liu C, Suharitdamrong W. Pardalos PM, Carney PR, Sackellares JC.

Distinguishing independent bitemporal form unilateral onset in epileptic patients by the

analysis of nonlinear characteristics of EEG signals. Epilepsia 46 Suppl. 8 :321 (Abst.

3.131), 2005.

52. Shaiu DS, Iasemidis LD, Sackellares JC, Suharitdamrong W, Shenk D, Carney PR.

Quantitative methods for distinguishing neonates at risk for seizures from normal

newborns. PAS 2005: 57: 2655.

53. Shiau DS, Nair SP, Iasemidis LD, Carney PR, Norman

W, Principe JC, Pardalos PM,

Suharitdamrong W, Cho J, Sackellares JC. Seizure warning and dynamic response to

electrical stimulation in a rodent model of chronic limbic epilepsy. 2005; IEEE EMBC.

54. Singh T, Little LE, Nathoo S, Snively C, Ringdahl D, Winger K, Jackson C, Carney PR,

Liu Z, Borum P. Evaluating potential growth abnormalities in a patient population.

Annual Meetings of the American Epilepsy Society and Canadian League Against

Epilepsy, 2006.

55. Snively C, Carney PR, Liu Z, Ringdahl D, Winger K, Jackson C,

Singh T, Little LE,

Borum PR. Developing an Evidence-Based Ketogenic Therapy Program for Treatment

of Epilepsy. Annual Meetings of the American Epilepsy Society and Canadian League

Against Epilepsy, 2006.

56. Sepulveda H, Hoang-Minh L, Parekh MB, Hadlock A, Norman W, Sanchez JC,. Ditto

WL, Carney PR, Mareci T. Evolution of Temporal Lobe Epilepsy Observed with 11.1

Tesla MRI In Vivo. 60th Annual Meeting of the American Epilepsy Society, San Diego,

CA, 2006.

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57. Parekh M, Hoang-Minh LB, Sepulveda H, Haddock A, Norman W, Sanchez JC, Ditto

WL, Carney PR, Mareci TH. Diffusion Tensor MR Imaging of the Rat Model of Mesial

Temporal Lobe Epilepsy. 60th Annual Meeting of the American Epilepsy Society, San

Diego, CA, 2006.

58. Nair SP, Norman WM, Dance L, Pardalos PM, Principe J, Carney PR. Development of

Spatiotemporal Dynamical Transitions during Epileptogenesis. 60th Annual Meeting of

the American Epilepsy Society, San Diego, CA, 2006.

59. Zhang Q, Zhao Z, Liu, Carney PR, Jiang H. Imaging of Seizure-Onset Zone with Non-

Invasive Photoacoustic Tomography in a Rat Model of Focal Seizures. 60th Annual

Meeting of the American Epilepsy Society, San Diego, CA, 2006.

60. Hoang-Minh L, Sepulveda H, Parekh M, Hadlock A, Norman W, Sanchez JC, Ditto WL,

King MA, Carney PR, Liu Z, Mareci T. MRI Measurements at 17.6 Tesla in an Animal

Model of Mesial Temporal Lobe Epilepsy Correlated with Histological Analysis. 60th

Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006.

61. Bongiolatti SR, Fennell EB, Carney PR. Sleep Fragmentation and Disruptive Behaviors

in Children with Epilepsy and Co-morbid Sleep Disordered Breathing. Journal of the

International Neuropsychological Society 2006; 12(S1): 109.

62. Zhang Q, Liu L, Carney PR, Jiang H. Imaging of Seizure-Onset Zone with Non-Invasive

Photoacoustic Tomography in a Rat Model of Focal Seizures. 60th Annual Meeting of the

American Epilepsy Society, San Diego, CA, 2006.

63. Parekh MB, Hoang-Minh L, Sepulveda H, Handlock A, Norman W, Sanchez, JC Ditto

WL, Carney PR, Mareci TH. Diffusion Tensor MR Imaging of the Rat Model of Mesial

Temporal Lobe Epilepsy. 60th Annual Meeting of the American Epilepsy Society, San

Diego, CA, 2006.

64. Geyer JD, Carney PR, Dillard SC. Epilepsy and Restless Legs Syndrome. 60th Annual

Meeting of the American Epilepsy Society, San Diego, CA, 2006.

65. Martynyuk, AE, Carney PR, Dennis DM, Laipis PJ. Mechanisms of Epileptic Activity in

Phenylketonuria: Decreasing Levels of Phenylalanine Trigger Seizures. 60th Annual

Meeting of the American Epilepsy Society, San Diego, CA, 2006.

66. Loomis-Roux AR, Smith-Bonahue T, Carney PR. School Adjustment in Children with

Epilepsy: Examining Parent Perceptions. 60th Annual Meeting of the American Epilepsy

Society, San Diego, CA, 2006.

67. Zhang Q, Liu Z, Jiang H, Carney PR. Imaging of epilepsy using photoacoustic

tomography. 60th Annual Meeting of the American Epilepsy Society, San Diego, CA,

2006.

68. Sanchez JC, Liu Z, Carney PR. Identifying the seizure onset zone using amplitude

modulated slow potentials, gamma, fast gamma, and neural ensemble activity. 60th

Annual Meeting of the American Epilepsy Society, San Diego, CA, 2006.

69. Geyer JD, Carney PR, Dillard SC, Parrish P. Anti-depressant Medications, Neuroleptics

and Prominent Eye Movements During. Sleep, Vol 29 Abstract Suppl 2006 p.A34.

70. Zhang QZ, Liu Z, Carney PR, Jiang HB, Imaging epilepsy using finite-based

photoacoustic tomography: Initial in vivo results. Optical Society America Annual

Meeting, Lauderdale, FL 2006.

71. Singh, T, Little, LE, Nathoo S, Carney PR, Borum PB. Evaluating potential growth

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abnormalities in a patient population at Shands/UF on ketogenic therapy for seizures.

Experimental Biology Meeting, 2006.

72. Sanchez JC, Gunduz A, Carney PR, Principe JC. Extraction and localization of

mesoscopic motor control signals for human ECoG neuroprosthetics. Neuroplasticity

Conference, 2006.

73. Sanchez JC, Principe JC, Carney PR. Choosing the Appropriate Level of Abstraction

for Brain Machine Interfaces: Data Collection and Analysis Insights. DIMACS Workshop

on Data Mining, Systems Analysis, and Optimization in Neuroscience, Feb 15-17, 2006.

74. Carney PR. Dynamical EEG Properties in the Limbic Epilepsy Rat Model. DIMACS

Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience, Feb 15-

17, 2006.

75. Bongiolatti SR, Fennell EB, Carney PR. Sleep Fragmentation and Disruptive Behaviors

in Children with Epilepsy and Co-morbid Sleep Disordered Breathing, International

Neuropsychological Society, Boston, MA, Feb. 3-6, 2006. 2(S1):109, 2006.

76. Hwang Dong-UK, Talathi S, Carney PR, Ditto W, Myers S, Norman W, Simonotto J.

High frequency oscillations in the limbic rat model of temporal lobe epilepsy, J.

Computational Neuroscience, 2007.

77. Bing J, Vermuri BC, Ozarslam E, Carney P, Mareci T A novel tensor distribution for the

diffusion weighted MR signal. IEEE International Symposium on Biomedical Imaging:

From Nano to Macro. April 12-17, 2007.

78. Talathi SS, Carney, PR, Dong-Uk Hwang, Ditto W, Myers S, Simonotto J. High

frequency oscillations in rat model of chronic limbic epilepsy, CNS, Toronto, Canada,

July 2007.

79. Carney PR, Cadotte AJ, Ditto WL, Mareci T, DeMarse TB, Temporal Lobe Epilepsy:

Anatomical and Effective Connectivity, Conference on Computational Neuroscience (Feb

2008) Gainesville, FL.

80. Cadotte AJ, DeMarse TB, Ditto WL, Carney PR, Granger Causality Analysis of

Spontaneous Seizure in an Animal Model of Temporal Lobe Epilepsy, Pediatric Science

Days, Univ of Florida (March 2008) Gainesville, FL.

81. Cadotte AJ, DeMarse TB, Mareci T, Talathi S, Hwang DU, Ditto W, Carney PR,

Granger Causality Analysis of Spontaneous Seizure in an Animal Model of Temporal

Lobe Epilepsy, Gordon Research Conference- Mechanisms of Epilepsy and

Synchronization (Aug 2008) Waterville, ME.

82. Talathi SS, Dong-Uk Hwang, Ditto WL, Spano ML, Sepulveda H, Mareci T, Carney PR.

Chronobiology of epilepsy, Nature, 2008.1679.1, 2008.

83. Talathi SS, Dong-Uk Hwang, Ditto W, Carney PR. Loss of balance and circadian phase

reversal in an animal model of limbic epilepsy, IEEE BMES, St Louis.

84. Dong-Uk Hwang, Talathi SS, Winters J, Ditto W, Carney PR. Controlling firing activity

of population spikes during epileptogenesis in an animal model of temporal lobe

epilepsy, IEEE BMES, St Louis.

85. Geyer JD and Carney PR. The association between acute cerebral infarction and

restless legs. American Academy of Neurology 60th

Annual Meeting, Chicago, April 12-

19, 2008, Scientific Abstract Number 1548, Poster number P05.170.

86. Kumar R, Barmpoutis A, Vemuri BC, Carney PR, Mareci TH. Multi-fiber reconstruction

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from DW-MRI using a continuous mixture of von mises-fisher distributions. IEEE Conf.

on Mathematical Methods for Biomedical Image Analysis. June, 2008.

87. Zafar R and Carney PR. Gene therapy for temporal lobe epilepsy: the role of adeno

associated viral vector delivered somatostatin. Soc for Neuroscience Annual Meeting,

Platform, Wash D.C. 2008.

88. Cadotte A. DeMarse T, Carney PR. Analysis of spontaneous temporal lobe seizures

using granger causality. Soc for Neuroscience Annual Meeting, Platform, Wash D.C.

2008.

89. Parekh MB, Sepulveda, Hoang King M, Mareci T, Carney PR. Diffusion tensor MR

imaging of a rat model of temporal lobe epilepsy. 38th Annual Meeting, Society for

Neuroscience 15-19 Nov 2008. Epilepsy: Circuits and Therapy.

90. Zafar R, Carney PR. Adeno associated viral vector delivered somatostatin as a

candidate for gene therapy for temporal lobe epilepsy. 62nd Annual Meeting of the

American Epilepsy Society, Biennial North American Regional Epilepsy Congress,

December 8, 2008 Platform Session #: A.08.

91. Cadotte A, DeMarse T, Ditto W, Carney PR. In vivo causal analysis of initiation,

propagation and termination of spontaneous temporal lobe seizure. 62nd Annual Meeting

of the American Epilepsy Society, Biennial North American Regional Epilepsy Congress,

December 8, 2008 Platform Session #: A.03

92. Talathi SS, Hwang DU, Cadotte A, Ditto WL, Carney PR. Imbalance in hippocampal

network synchrony during epileptogenesis. 62nd Annual Meeting of the American

Epilepsy Society, Biennial North American Regional Epilepsy Congress, December 6,

2008 Poster Session IW.O3.

93. Kantorovich, S, Astary GW, Parekh M, Mareci TH, Sarntinoranont M, Carney PR.

Convection enhanced delivery as a local anit-convulsant delivery method for the

treatment of epilepsy. Soc for Neuroscience Annual Meeting, Chicago, 2009.

94. Zafar R, King MA, Frazier CJ, Carney PR. Adeno-associated viral vector delivered

somatostatin as a neuroprotective agent for temporal lobe epilepsy. Soc for Neuroscience

Annual Meeting, Chicago, 2009.

95. Parekh MB, Triplett WT, King MA, Mareci TH, Carney PR. Early damage in the

parahippocampal gyrus after status epilepticus as a structural signature for the

development of spontaneous seizures-a longitudinal study using enhanced MRI. Soc for

Neuroscience Annual Meeting, Chicago, 2009.

96. Talathi SS, Hwang DU, Ditto WL, Carney PR. Circadian control of neural excitability in

an animal model of temporal lobe epilepsy. 61st Annual Meeting of the American

Academy of Neurology, 2009.

97. Talathi SS, Hwang

DU, Miliotis A, Carney

PR, Ditto

WL. Synchrony with Shunting

Inhibition. Eighteenth Annual Computational Neuroscience Meeting CNS 2009.

98. Astary GW, Kantorovich S, Parekh MB, Triplett WT, Carney PR, Mareci TH,

Sarntinoranont M. Regional convention-enhanced delivery of gadolinium-labeled

albumin in the rat hippocampus in vivo. BMES, 2009.

99. Myers S, Talathi S, Carney PR. Determining the firing rate of interictal population

spikes leading to seizures. 2.102, 63rd

Annual Meeting of the American Epilepsy Society,

Boston, MA, 2009.

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100. Zhou J, Talathi S, Cadotte A, Liu Z, Holmes G, Carney PR. The effects of

hippocampus CA1 single neuron firing properties on interictal spike patterns during onset

in a rat model of temporal lobe epilepsy. 3.330, 63rd

Annual Meeting of the American

Epilepsy Society, Boston, MA, 2009.

101. Talathi S, Nandan M, Ditto W, Khargonekar P, Carney PR. Support vector machine

algorithms for early seizure detection in an animal model of temporal lobe epilepsy.

3.242, 63rd

Annual Meeting of the American Epilepsy Society, Boston, MA, 2009.

102. Cadotte A, Talathi S, Zhou J, Myers S, Hwang D, Ditto W, Carney PR. Analysis of

hippocampal interdependencies for early seizure detection. 3.067, 63rd

Annual Meeting of

the American Epilepsy Society, Boston, MA, 2009.

103. Sarntinoranont, M., Kim, J.H., Carney, P.R., and Mareci, T.H. Diffusion Tensor

Imaging- based Computational Models of Convection-Enhanced Delivery. 6th Annual

World Congress of the International Brain Mapping & Intraoperative Surgical Planning

Society (IBMISPS), Boston, MA, August 26-29, 2009.

104. Astary, G.W., Kantorovich, S., Parekh, M.B., Carney, P.R., Mareci, T.H and

Sarntinoranont, M. Convection Enhanced Delivery of an MR Contrast Agent to the

Dorsal and Ventral Hippocampus. 2009 BMES Annual Meeting, Pittsburgh, PA, October

7-10, 2009.

105. Cadotte A, Parekh M, Triplett W, Talathi S, Mareci T, Carney P. Integration of structure,

behavior, and function for temporal lobe epilepsy: Evidence for future directions for

exploration of ictogenic and epileptogenic transitions. American Clinical

Neurophysiology Society, Annual Meeting Feb 2-7, 2010, San Diego, CA, Poster and

Abstract B109.

106. Ratnadura S, Talathi SS, Carney PR, Pramod P. Khargonekar PP. Synchronization

induced by signal propagation delays in inhibitory networks. Nineteenth Annual

Computational Neuroscience Meeting July 24-30, 2010, San Antonio, Texas.

107. Talathi SS, Ratnadura S, Kantorovich S, Carney PR, Khargonekar PP. Control of neural

synchrony with light-activated opsins. Nineteenth Annual Computational Neuroscience

Meeting July 24-30, 2010, San Antonio, Texas.

108. Kim, J.H., Astary, G., Kantorovich, S., Mareci, T.H., Carney, P., Sarntinoranont, M.

Measurement of In Vivo Tracer Distribution during CED in the Rat Brain using DCE-

MRI. 37th

Annual Mtg and Expo of the Controlled Release Society, Portland, OR, July

10-14, 2010, accepted.

109. Luis Colon-Perez, William Triplett, Stephen Eisenscheck, Paul Carney, Thomas Mareci.

Fiber tracking the cingulum in the human brain using a novel statistical model of water

diffusion measured with MRI. University of Florida College of Medicine Research Day.

04/24/10.

110. Mansi Parekh, William Triplett, Paul Carney, Thomas Mareci. White Matter

Reorganization in a Rat Model of Temporal Lobe Epilepsy Observed using Enhanced

MRI. University of Florida College of Medicine Research Day. 04/24/10.

111. Garrett Astary, Svetlana Kantorovich, Jung Hwan Kim, Sung Jin Lee, Tatiana Nobrega,

Mansi Parekh, William Triplett, Paul Carney, Thomas Mareci, Malisa Sarntinoranont.

Convection-Enhanced Delivery for the Potential Delivery of Therapeutic Agents for the

Treatment of Epilepsy. University of Florida College of Medicine Research Day

04/24/10.

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112. Svetlana Kantorovich, Philip Barish, Sachin Talathi, Shivakeshavan Ratnadurai, Junli

Zhou, Stephen Myers, William Ogle, Pramod Khargonekar, Paul Carney. Control of

hippocampal neural activity using optical stimulation. University of Florida College of

Medicine Research Day. 04/24/10.

113. Allen H, Lee

K, Jones

L, Andrade

E, Carney

P, Liu

Z, Borum

P. Ketogenic Therapy

Education Modules for Caregivers and Healthcare Professionals. Experimental Biology

2010 in Anaheim CA.

114. Kantorovich S., Astary, G., Parekh M.B., Mareci T.H., Sarntinoranont M., Carney P.

Status epilepticus affects hippocampal structure and infusate distribution

profiles. Neuroscience 2010. San Diego CA, Nov 13-17th, 2010, submitted.

115. Cadotte A, Myers S, Parekh M, Talathi SS, Mareci T, Carney PR. Slow changes during

epileptogenesis in a spontaneously seizing animal model of temporal lobe epilepsy.

American Epilepsy Society 64th

Annual Meeting Dec 3-7, 2010.

116. Talathi SS, Zhao J, Cadotte A, Carney PR. Circadian rhythm of core body temperature

in an animal model of chronic epilepsy. American Epilepsy Society 64th

Annual Meeting

Dec 3-7, 2010.

117. Zhen Yuan, R. Jiang, L. Ji, J. Zhou, P. Carney, H. Jiang. Combining Granger causality

and diffuse optical tomography to investigate the effective connectivity in temporal lobe

epilepsy. Poster No. 3.235. American Epilepsy Society 64th

Annual Meeting Dec 3-7,

2010.

118. Qizhi Zhang, B. Hu, Z. Yuan, J. Zhou, P. Carney, H. Jiang. High temporal resolution

photoacoustic imaging for seizure localization and network mapping. Poster No. 3.172

American Epilepsy Society 64th

Annual Meeting Dec 3-7, 2010.

119. Ruixin Jiang, Z. Yuan, Q. Zhang, L. Ji, J. Zhou, P. Carney, H. Jiang. Noninvasive

imaging of epilepsy using fast diffuse optical tomography. Poster No. 3.157. American

Epilepsy Society 64th

Annual Meeting Dec 3-7, 2010.

120. Andrade E, Liu Z, Eisenschenk S, Cibula, SJ, Goldsmith I, Parekh M, Triplett W,

Cadotte A, Mareci T, Carney PR. 3T Brian MRI and Ictal Findings of patients with

nonlesional partial epilepsy refractory to medical treatment. American Epilepsy Society

64th

Annual Meeting Dec 3-7, 2010.

121. Alex Cadotte, S. Myers, M. Parekh, S. Talathi, T. Mareci and P. Carney. Slow changes

in functional connectivity during epileptogenesis in a spontaneously seizing animal model

of temporal lobe epilepsy. 1.056 American Epilepsy Society 64th

Annual Meeting Dec 3-7,

2010.

122. Astary GW, Kantorovich S, Carney PR, Sarntinoranont M, Mareci TH. Gd-albumin

relaxivity in the rat thalamus at 11.1T. ISMRM 2011 Annual Meeting.

123. Talathi SS, Carney PR. Khargonekar PP. In-phase neural synchrony through optical

stimulation. Poster No. 44.10/H38. 2010 Neuroscience. San Diego, CA: Society for

Neuroscience, 2010. Online.

124. Twyford P. DeMarse T, Barish P, Ogle W, Carney PR. Spatiotemporally precise

optical system for controlling neural activity in vitro. Poster No. 816.1/NNN22. 2010

Neuroscience San Diego, CA: Society for Neuroscience, 2010.

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Selected Invited Talks at Regional, National and International Meetings

1. Evaluation and Treatment of the Seizing Child, University of Florida, Emergency Medicine

Clinical Lecture, August, 1998

2. Cephalon, Inc., Speaker Bureau on Sleep Disorders

3. Pediatric epilepsy surgery; evaluation and management, University of Florida pediatric

nursing in-service, August, 1998

4. Sleep Disorders. East Side Community Health Center: Florida representative Karen Chestnut,

Acute repetitive seizures and other epileptic emergencies: management strategies, University

of Florida, Department of Pediatrics, September, 1998,

5. Temporal lobe epilepsy surgery during childhood. Neurology Grand Rounds, State

University of New York, Buffalo, NY, February, 1998

6. University of Michigan, Ann Arbor, Pediatric Resident’s Noon Conferences 1999

7. University of Florida College of Medicine medical student and pediatric house officer rural

medicine expedition and course (Nicaragua). Group leader: Donald Eitzman, M.D., February,

1999

8. Update on Epilepsy: Consensus Conference in Child Neurology, Orlando, Fl, Management of

medically refractory seizures, University of Florida, Department of Pediatrics, February, 1999

9. University of Valparaiso School of Medicine, Department of Cell Biology, Neuroscience

Lecture series, Director: E. Couve, 1990-92

10. Health in a Heartbeat radio program on WUFT-FM (Classic 89), Topic: Spinal muscular

dystrophy, February, 2000

11. Public Relations, A Question of Health” TV 20, Theme: Sleep Disorders, Panel Member,

January, 2000

12. University of Florida/Shands Hospital Epilepsy Surgery Patient Reunion, Invited Speaker,

Topic: New Anticonvulsant Drugs, September, 2000

13. Children’s Miracle Network, TV 20, PersonalPortrait: Sara Higgins. Story reviews the

personal experience of an 8-year-old child with refractory epilepsy undergoing a presurgical

and surgical evaluation for epilepsy surgery, June, 2001

14. American Epilepsy Society Annual Meeting, Special Interest Group and Participatory

Roundtable, New Orleans, LA. Topic: Brain Dynamics in Rat Chronic Limbic Epilepsy

Model, 2001

15. Children’s Miracle Network, Radio Telethon Fund Raiser. Interview reviews medical needs

of children with complex neurologic problems, including epilepsy, sleep disorders, and

developmental delay, August, 2001

16. Predictability of seizures in a transgenic epilepsy-prone mouse model, Spring Epilepsy

Research Conference, Cayman Islands, Platform session, April, 2001

17. Sleep disordered breathing during childhood: diagnosis and treatment, Nemours Children

Foundation Grand Rounds, Jacksonville, March, 2001

18. Practical Approach to the Diagnosis and Management of Sleep Disorders, North Florida

Neurological Society, February 13, 2002

19. Recent Advances in Modeling and Prediction of Epileptic Seizures, Grand Rounds,

Department of Neurology, Case Western Reserve University, Cleveland, OH, March 1, 2002

20. Biomedical Research Partnership seminar series. Colleges of Medicine and Biomedical

Engineering. University of Florida. Talk: Seizure prediction in the H218 sphingosine 1-

phosphate mouse model. January 15, 2002

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21. Practical Approach to the Diagnosis and Management of Sleep Disorders, North Florida

Neurological Society, February 13, 2002

22. University of Chile and University of Valparaiso, Chilean Pediatric Neurology Society,

Valparaiso, Chile, 1st International Iberoamerican Pediatric Neurology Conference, Topics:

Childhood Epilepsy and “Childhood Sleep Disorders, March, 2003

23. Seizure Prediction and Substrates for Seizure Prediction Platform, Topic; Seizure prediction

by nonlinear time series analyses of brain electrical activity. April 23, 2003

24. Florida Chapter AAP Annual Meeting and Florida Pediatric Alumni Association Annual

Meeting, Topic: “Recent Advances in the Diagnosis and Treatment of Pediatric Epilepsy”.

June 20, 2003

25. The First International Collaborative Workshop on Seizure Prediction, International Seizure

Prediction Group, Bonn, Germany. Topic: Seizure Prediction in a Generalized Epilepsy

Animal Model, March, 10, 2003

26. Grand Rounds, University of Florida, Department of Pediatrics, Jacksonville, FL, Title:

Catastrophic Childhood Epilepsy: Advances in Diagnosis and Management, April, 23, 2004

27. Grand Rounds, University of Arkansas, Department of Pediatrics. Topic: Modeling and

Seizure Prediction, May 12, 2004

28. Conference on Data Mining in Biomedicine, Center for Applied Optimization, Modeling and

Computation for Engineering, Science and Industry, College of Engineering, University of

Florida, Gainesville, Topic: A Quantitative EEG Method for real-time Detection of Neonatal

Seizures in the Neonatal Intensive Care Unit. February 16-18, 2004

29. Quantitative Neuroscience/Neural Engineering Seminar, University of Florida, Neonatal

Seizures, March 2, 2004

30. Children’s Medical Services, Nursing Symposium, Topic: Childhood Sleep Disorders:

Evaluation and Management, April, 2004

31. University of Valparaiso, Society for Pediatric Neurology, Topics: Phamacoresistant

Childhood Epilepsy and Evaluation and Treatment of Sleep Disorders, June, 2004

32. American Academy of Neurology, Miami, FL, Topic: Seizure Prediction in a Limbic Model

of Temporal Lobe Epilepsy, May 2, 2005

33. Research Seminar Grand Rounds, Department of Physical Medicine and Rehabilitation,

University of Florida, Gainesville, FL Topic: Brain Machine Interface for Epilepsy,

September 14, 2005

34. Chilean Pediatric Society, Chile, 1st International Iberoamerican Pediatric Neurology

Conference, Topics: Childhood Epilepsy and Childhood Sleep Disorders, October, 2005

35. Conference on Systems Analysis, Data Mining, and Optimization in Biomedicine, Topic:

Dynamical Characteristics in Rat Chronic Limbic Epilepsy Model, February 2-4, 2005

36. Neuroscience Grand Rounds, Topic: Pathophysiology of Temporal Lobe Epilepsy, University

of Florida, February 5, 2006

37. Conference on Data Mining, Systems Analysis and Optimization in Neuroscience University

of Florida. http://www.ise.ufl.edu/cao/neuroscience2006/ Topic: EEG Dynamics in an

Animal Model of Temporal Lobe Epilepsy, February 15-17, 2006.

38. College of Engineering Recruitment, University of Florida, Gainesville, FL Topic: Brain

Dynamics and Neural Networks in Epilepsy, February 17, 2006

39. 4th International Sleep Disorders Forum Rome, Italy, 7-8 September, 2006

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40. DIMACS Workshop on Data Mining, Systems Analysis, and Optimization in Neuroscience,

Gainesville, FL, Topic: Dynamical EEG Properties in the Limbic Epilepsy Rat Model,

February 15-17, 2006

41. Florida Neurological Society, Topic: Epilepsy Behavioral and Cognitive CoMorbidity in

Pediatric Epilepsy: Recognition, Mechanisms, Assessment and Treatment., Orlando, Florida,

December 14, 2006

42. 23rd

Congreso de Psiquiatria y Neurologia de la Infancia y la Adolescencia. Topics:

Seizure Prediction; Emerging Technologies for Epilepsy: Diffusion Tensor Imaging and

Photoacoustic Tomography. Viña del Mar, Chile, South America, October 12-14, 2006

43. 60th

Annual Meeting of the American Epilepsy Society, Sensing the Brain; Engineering

Special Interest Group, Topic: Neural Prosthetic for Epilepsy, , San Diego, CA. December 1,

2006

44. 4-D Neuroimaging 2rd

Annual International Users Group Meeting, Denver, June 6-8, 2007

45. Data Mining, Systems Analysis & Optimization in Biomedicine University of Florida College

of Engineering, March 28-30, 2007

46. Neural Interface for Repair and Treatment: Potential for Epilepsy, Mt Sinai School of

Medicine, New York, NY, September 17, 2007

47. Third International Seizure Prediction Workshop, Talk: Dynamics of a Limbic Epilepsy

Model, Freiburg, Germany. September 30-October 4, 2007

48. International Conference on Translational Research, Peking Union Medical College

Hospital (PUMC), Topic: Neural Interface for Repair and Treatment: Potential for Epilepsy.,

Beijing, China, November 11-13, 2007

49. State Key Laboratory of Brain and Cognitive Science Institute of Psychology, Chinese

Academy of Sciences.. Topic: Sleep disorders in children and adults. Beijing, China,

November. 15, 2007

50. Capital Medical University Beijing Tiantan Hospital. Topic: Brain Machine Interface for

Epilepsy. Beijing, China, November 15, 2007.

51. Neural Interface for Repair and Treatment: Potential for Epilepsy, University of Florida

Department of Neuroscience, January 16, 2008

52. Conference on Computational Neuroscience 2008. Topic: Temporal Lobe Epilepsy:

Anatomical and Effective Connectivity. University of Florida, Center for Applied

Optimization, Gainesville FL February 20, 2008

53. American Association of Critical-Care Nurses. Swamped with Knowledge 2008. Topic: To

Seize or Not to Seize: That is the Question, Gainesville, Florida, March 1, 2008

54. XXIX Annual Child Neurology Postgraduate Course Miami Children’s Hospital. Topics:

Sleep and Epilepsy and Epilepsy Co-Morbidity. Miami, Florida. May 2, 2008

55. 7th Curso International de Neuropsiquiatria Infantile. Viña del Mar, Chile, May 30-31, 2008.

56. 4-D Neuroimaging 3rd

Annual International Users Group Meeting, , Barcelona, Spain, July

13-15, 2008

57. Neural Interface for Repair and Treatment: Potential for Epilepsy, Grand Rounds, Emory

University/Georgia Tech, Atlanta, Department of Neuroscience, September 9, 2008

58. Biomedical Engineering Update: University of Florida College of Engineering, Department

of Biomedical Engineering Advisory Board Meeting, October 17, 2008

59. Neural Interface for Repair and Treatment of Epilepsy, Department of Neurology Grand

Rounds, Wake Forest University, December 15, 2009.

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60. Optogenetics Deconstruction of Hippocampus Epileptic Neural Circuitry. American Clinical

Neurophysiology Society, Annual Meeting San Diego, CA, Feb 2-7, 2010

61. Circadian Regulation of Neural Excitability in Temporal Lobe Epilepsy. Nocturnal Frontal

Lobe Epilepsy: An Interdisciplinary Perspective. National Institutes of Health Office of Rare

Diseases Research and Alliance for Epilepsy Research. Sanibel Symposium. Sanibel, FL,

Feb 11-12, 2010

62. Grand Rounds, Curing Epilepsy: Progress and Future Directions, Medical College of

Milwaukee, Milwaukee, WI Dec 13, 2010

63. Grand Rounds, Epilepsy: From Bench to Bedside, University of Florida Department of

Pediatrics, Dec 17, 2010

Selected Articles/Interviews

“Spinal muscular dystrophy”, Health in a Heartbeat radio program on WUFT-FM (Classic

89), 6/1999

“A Question of Health”, Public Relations, TV 20, Theme: Sleep Disorders, Panel Member,

01/2000

“Medical needs of children with complex neurologic problems, including epilepsy, sleep

disorders, and developmental delay”. Children’s Miracle Network, Radio Telethon Fund

Raiser. 8/2001

“Story reviews the personal experience of an 8 year-old child with refractory epilepsy

undergoing a presurgical and surgical evaluation for epilepsy surgery”, Children’s Miracle

Network, TV 20, Personal Portrait:. 6/2001

“Hannah Beth’s Story”, Channel 20 TV (Sarasota, FL) news interview on mitochondrial

disorders in children, 7/2004

“UF tries out mind-controlled computers”. Gainesville Sun, July 31, 2004

“Childhood Sleep Disorders”, University of Florida College of Journalism, 2/2004

“Mathematical Analysis of EEG May Lead To Quicker Diagnosis”. Epilepsy Action feature

story, 2005

“New Brain Monitoring Method Would Pinpoint Babies at Risk for Seizure”, Medgadgets

feature Story, 2005

“Sleep Disorders in Children with Epilepsy: More Common than You Think”, Feature Story

Epilepsy.com, 2005

“Epilepsy - New brain monitoring method would pinpoint babies at risk for seizures”.

Epilepsy News today feature story, 2005

“Solving sleep problems helps epileptic children”, University of Florida feature story, March

30, 2005.

“UF researchers explore epilepsy, sleep problems”, Feature story Gainesville Sun, April 18,

2005

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“Confusion and speech problems are frequent signs of seizures, but babies offer few such

clues as to what ails them”, UF feature story Tuesday, 17-May-2005 AZoMed.com, 2005

“Epilepsy Surgery”, Children’s Miracle Network feature story, 2005

“Recreating Epilepsy”, University of Florida College of Engineering feature story, 2006

“Convention Enhanced Delivery in Epilepsy”, University of Florida Foundation Feature

Story, Nov, 2009.

http://www.floridatomorrow.ufl.edu/gallery/video_galleries/Initiatives/Eng_Neuro_Thera_Vi

deo.htm

Neural Interface Technology. University of Florida Biomedical Engineering Society seminar.

Feb 7, 2010.

“Monsters in My Head”. Animal Planet, Medical Detective Work,

http://animal.discovery.com/ August 25, 2010.

“Reflex Epilepsy: Features in The Body Odd on msnbc.com http://bodyodd.msnbc.msn.com/,

The Press-Enterprise.com http://topics.pe.com Zacquisha http://zacquisha.com September 20,

2010.