Pathophysiology Shock
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Transcript of Pathophysiology Shock
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Pathophysiol
ogy Cyntia Dasuki1061050004
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Hypovolemic shock refers to a medicalor surgical condition in hich rapid!uid loss results in multiple organ
failure due to inade"uate circulatingvolume and su#se"uent inade"uateperfusion$
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%he human #ody responds to acutehemorrhage #y activating the folloingma&or physiologic systems' the
hematologic( cardiovascular( renal( andneuroendocrine systems$
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%he hematologicsystem
)cute severe #loodloss
)ctivating coagulation
cascade * contracting#leeding vessels
form an immature cloton the #leeding source
Platelets are activated
damaged vessel
e+poses collagen
causes ,#rindeposition and
sta#ili-ation of the clot
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%he cardiovascularsystem
increasing the heartrate
constrictingperipheral #lood
vessels
redistri#uting #lood to the #rain( heart( and kidneys and aayfrom skin( muscle( and ./ tract$
increasingmyocardial
contractility
%his response occurssecondary to an increased
release of norepinephrine anddecreased #aseline vagal tone
)lso responds#y(
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%he renal system
stimulating an increase inrenin secretion from the
&u+taglomerular apparatus
converted to angiotensin //
enin convertsangiotensinogen to
angiotensin /
)ngiotensin // has main e2ects(
#oth of hich help to reversehemorrhagic shock(vasoconstriction of arteriolarsmooth muscle( and stimulationof aldosterone secretion #y theadrenal corte+$
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%he neuroendocrinesystem
causing an increase incirculating antidiuretic hormone
3)DH
)DH is released from the posteriorpituitary gland in response to a decreasein the sodium concentration
)DH indirectly leads to an increasedrea#sorption of ater and salt 3aCl #y thedistal tu#ule( the collecting ducts( and the
loop of Henle$
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eference
Paul olecki$ Hypovolemic 7hock$8edscape$ 01$ Donloaded fromhttp'99emedicine$medscape$com
9article9:60145;overvie