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K = koilocytes

Microinvasive Squamous Cell CA: Invasive Squamous Cell CA:

What is the most sensitive test for high grade dysplasia of the cervix?A. Pap smearB. HPV DNA test for high risk typesC. HPV test for DNA type 16D. HPV test for DNA type 18E. HPV serum antibodies to DNA type 16

Test q (almost the same): What is the most sensitive test for high grade dysplasia of the cervix? HPV DNA test for at least 13 high risk types

HPV DNA is most sensitive test for High Grade dysplasia: Pap smear 55%; HPV DNA 95%

LUNG CANCER Large cell carcinoma, adenocarcinoma and squamous cell

carcinoma: can be cured by surgery if caught early (

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Squamous cell carcinoma: Small cell carcinoma:

Paraneoplastic Syndromes: Adeno CA (gastric) Acanthosis nigricans Small Cell CA Eaton-Lambert Bronchogenic CA Osteoarthropathy Gastric CA Seborrheic keratosis Pancreatic CA Migratory thrombophlebitis (Trousseaus) Small Cell CA ACTH (Cushings); ADH (iADH) Squamous cell CA hypercalcemia PTH-like (Hypercalcemia)

Carcinoid tumor (lung or liver usually) Serotonin, bradykinin (Carcinoid syndrome)

Test q:A 64y/o man has noted changes in the texture and color of skin in his armpit and groin over the past 3mo. On phys exam, there is thickened,darkly pigmented skin in the axillae and flexural areas of the neck and groin. These areas are neither painful nor pruritic. A punch biopsy specimen ofthe axillary skin shows undulating epidermal acanthosis w/hyperkeratosis and basal layer hyperpigmentation. Which of the following underlying

diseases is most likely to be present in this patient? Gastric adenocarcinoma (see above acanthosis nigricans)

Test q:A 50y/o white male is seen for a life insurance phys exam. Under his arms, in his groin area, and on the sides of his neck the skin is thickenedand black. You must examine the patient for possible __? Gastric adenocarcinoma (see above acanthosis nigricans)

Test q: The most common paraneoplastic syndrome: Hypercalcemia.

Test q:Autopsy of a 58y/o woman reveals calcified deposits in otherwise normal appearing lung and kidney tissues. Which of the following would most

likely also be found during this autopsy? Parathyroid adenoma.

Test q:A 62y/o male long-time cigarette smoker presents w/a 3mo history of new onset muscle weakness. He complains that during the day his

muscles gradually become weaker in a pattern similar to myasthenia gravis. Suspecting a paraneoplastic syndrome, the astute physician orders a plainfilm of the chest. The radiograph reveals a hilar mass of the left lung. Transbronchial endoscopic needle aspiration biopsy confirms malignancy. What

type of neoplasm is most probable? Squamous cell carcinoma of lung.

Viruses and Cancer (RNA) HCV Hepatocellular HTLV-1 T-cell leukemia/lymphoma

Test q: An RNA virus now known to participate in some cases of liver cancer is: HCV

Viruses and Cancer (DNA) EBV t(8;14) Burkitt L., NP CA, MC Hodgkin HBV (