Holiday Reminders

The University of Pittsburgh will be Thursday November 26-27 for the Thanksgiving

Recess. UPMC will be closed Thursday, November 27.

The University of Pittsburgh will be closed Wednesday, December 24 through

Monday,January 3, 2016. The Administrative Offices will be minimally staff and open

during this time. University and Hospital offices will reopen Monday, January 3.

D E PA R T M E N T H I G H L I G H T S

Pathology News

O C T O B E R 2 8 , 2 0 1 5

Keep your

eyes open

to your

mercies.

The man

who forgets

to be

thankful

has

fallen asleep

in life.

Robert Louis

Stevenson 1850-1894

Dear Colleagues:

Our Department of Pathology is successfully adjusting its methods and parame-

ters within the spirit of changes occurring in UPMC and the School of Medi-

cine. UPMC is transforming itself gradually but steadily towards an IDFS

(Integrated Delivery and Finance System). This is a system that attempts to

encompass both the clinical delivery service and a financial insurance arm. The

objective is to create motivations for synergy, which aim to contain the cost of

diagnostic and therapeutic care. As with other clinical services, our department

is now supervising in an integrated administrative manner the diagnostic clini-

cal services of all UPMC sites under the rubric of a Pathology Service Line

(PSL). The mission of PSL is to streamline and integrate laboratory and histo-

pathology activities. Both our anatomic and lab medicine faculty and staff had

already accomplished most of the PSL goals, making this task easier. Through

its strong central components of anatomic, genomic and clinical pathology and

the highly capable similar services in the peripheral hospitals, our department is

justified to feel proud for the clinical services it provides to the UPMC system

In the School of Medicine, our special lectures, electives and the first year

pathobiology course continue to be very popular. The special autopsy elective is

breaking records of popularity with the medical students. A few new grants

were added to our portfolio of funded research and the department is committed

to provide support by whatever means possible to all our faculty and trainees.

I am taking this opportunity to express my thanks to our administrative and

technical staff who so ably manage to carry us through the complex navigation

channels that we traverse, as we try to meet due diligence, high performance

and steady aim throughout the academic year.

Best regards,

George Michalopoulos, M.D., Ph.D.

Maud Menten Professor and Chair

Department Highlights

Page 1

Concussion Movie

Page 2-3

Faculty Highlights

Page 4-5

Grant Administration

Page 6

SURP and CMP Graduate

Program

Page 7

Residency -

Fellowship

Page 8-9

Medical School

Page 10

Publications

Page 11-15

Presentations

Page 16-17

ECU Tracking

Page 17

Seminars

Page 18

Administrative

Updates

Page 19

PITTSBURGH PATHOLOGY DEPARTMENT PLAYS

BIG ROLE IN UPCOMING BLOCKBUSTER MOVIE

Dr. Ronald Hamilton from our Neuropathology Division is being portrayed by Stephen Moyer (from

True Blood, an HBO series) in CONCUSSION a major motion picture starring Will Smith. The movie,

which is set to be released nationwide on Christmas Day, focuses on the amazing story of Dr. Bennet

Omalu, a Nigerian immigrant, who discovered a progressive neurodegenerative disease he called Chronic

Traumatic Encephalopathy (CTE) in a former NFL football player (Mike Webster). Bennet, a forensic

pathologist working with Dr. Cyril Wecht at the Allegheny County Medical Examiner’s Office, had just

finished his Neuropathology Fellowship at UPMC, where he had been taught about neurodegenerative dis-

eases by Ron. He brought the case to Ron for confirmation and what happened to Bennet next was de-

scribed in a 2007 article in GQ called “Game Brain” (Jeanne Marie Laskas), which was the inspiration for

the movie. Ron’s role in the discovery of CTE was detailed in the book “League of Denial” (October,

2013); but how he will be portrayed in the movie is not known.

During the filming in Pittsburgh, Ron served as an informal advisor meeting with writer-director Peter

Landesman several times and he also supplied numerous props for the movie. During one of these visits,

Ron showed Peter the elaborate process required to simply get a slide ready to view under the microscope.

Peter was especially impressed with Jonette Werley, who has been with the Neuropathology Division for

30 years. Because of her expertise in Neurohistology, Bennet had brought the case to her for processing. A

crew spent a day filming Jonette for a short sequence that will be in the film. She’s a star!! Probably

the first histologist to make it to the big screen.

P A G E 2

Ron was able to get to the set twice and visit with Will Smith.

On set, he was interviewed by a film crew who were apparently gathering behind-the-scenes footage for

a bonus feature on the CONCUSSION DVD.

August 31, 2015: Just before the beginning of the NFL season, Sony pictures released a trailer for CON-

CUSSION. Stephen Moyer (as Ron) can be seen in one scene in the trailer (0:55 sec) with his back

turned and his beard partly visible. This can be found on YouTube.

It was recently announced that CONCUSSION will be the Centerpiece of the American Film Institute

(AFI) festival November 11, 2015. The AFI is also awarding Will Smith the Hollywood Actor Award

for his role as Bennet Omalu.

P A G E 3

P A G E 4

Faculty Highlights

Marshall Austin, M.D., Biosketch citation in the Journal of American Of Cytopathology , Volume LII,

Number 5, September 2015.

Rohit Bhargava, M.D. Simplified and Illustrated Breast pathology: A book for All Breast Care Providers.

Published May 2015. Jaypee Medical Brothers and Publishers. Editor/Sole Author: Rohit Bhargava

John Ozolek, M.D.

Elected Chair of the Practice Committee of the Society for Pediatric Pathology (2016-2018).

Liron Pantanowitz, M.D.

Two pathology images won the competition held by UPCI called “Images of Fighting Cancer”. They will

be on display at this year’s Science 2015-Unleashed! Wednesday, Thursday, and Friday, 7–9 October, at

Alumni Hall. After the exhibit the Images will be hung in the Hillman Cancer Center for all to see.

Chengquan Zhao , M.D. was honored as guest professor of Obstetrics and Gynecology Hospital of Fudan

University, the largest OB/Gyn hospital in China on September 17, 2015.

Ralph Nauman, Retired after 41 years of service Dr. Donald Kelley, retired after 13

at the Clinical Laboratories. years at the Institute of Transfusion

Medicine.

Best Wishes for a Happy Retirement

Parmjeet Randhawa, M.D.

Served on the Distinguished Faculty Poster Review Panel, American Society of Transplantation, Cutting

Edge in Organ Transplantation Meeting, Chandler, Arizona, February 5-7, 2015.

Chaired the Business Meeting of the American Society of Transplantation, Transplant Diagnostics Com-

munity of Practice, American Transplant Congress, Philadelphia, PA, May 3, 2015.

Chaired the Concurrent Oral Abstract Sessions on “BK virus Infection after Kidney Transplantation” at

American Transplant Congress, Philadelphia, PA, May 4, 2015

Participated in World Health Organization ( WHO) and National Institute for Biological Standards and

Control (NIBSC) Collaborative Study to Validate an International Standard for BK virus nucleic acid

technology based assays, January 2015.

Faculty Highlights

P A G E 5

Award winning abstracts presented by Transplant Pathology Trainees at National Meetings

Gang Zeng, a post-doctoral fellow working with Dr. Randhawa, was the recipient of Best Trainee Abstract

Travel Award from The American Transplant Society of Transplantation Infectious Disease Community of

Practice. The title of the poster was “ Prospects of differentiating T-cell mediated rejection from BKV

nephropathy using next generation sequencing of the T-cell receptor”. This poster was presented at

the American Transplant Congress, Philadelphia, PA, on May 2, 2015. Related work was presented at

the Annual Felllows Conference on Advances in Organ Transplantation, Cambridge, MA, on. April 16,

2015, where it was conferred with the Most Innovative Abstract Award in the Basic Science Category.

Gang Huang, a Visiting Research Scholar from Guangzhou, China, visiting Dr. Randhawa’s laboratory, was

recipient of a Poster of Distinction Award from the American Transplant Congress. The titlel of the poster

was “ Evaluation of the gastrointestinal tract as a potential router of primary polyomavirus infection”. It was

presented at the American Transplant Congress, Philadelphia, PA, May 2, 2015 (Recipient of Poster of Dis-

tinction Award).

Sarah Voss, Clinical Fellow in Transplantation Pathology was the recipient of Recipient of The CEOT

Young Innovator Award. This work was presentated at the American Society of Transplantation Cutting

Edge of Organ Transplantation (CEOT) Meeting, Chandler, Arizona, Feburary 5-7, 2015. The title of the

abstract was“ Glomerulitis in non-antibody mediated glomerular injury”.

Grant Administration

P A G E 6

Character cannot be

developed in ease

and quiet. Only

through experience

of trial and suffering

can the soul be

strengthened,

ambition inspired,

and success

achieved.

Helen Keller

(1880-1968)

VISAS

The number of visa applications in the Department of Pathology has grown

considerably over the past several years; in addition, Federal and University

requirements concerning the applications have become more involved. The

once paper process is now an electronic submission to the Office of Interna-

tional Services. Time is still of the essence and if you plan to bring on a

foreign national Visiting Scholar or Post Doc, please allow at least three (3)

months for the internal approval process, exchange of visitor information,

submission and flow of paperwork through OIS.

If you have specific questions concerning visas, the application process or

policies for the department, please contact Mary Lou Benedetti

(benedettim@upmc.edu) or April Lehman (lehmanad@upmc.edu).

CONFLICT OF INTEREST

REMINDER: The Office of Research will not submit any proposal that

involves faculty who are non-compliant. Continuing projects will not be

processed as well, until the required compliance modules and forms are

complete.

CARY WU, PH.D. GRANTS RECEIVED

Cary Wu, Ph.D. NIH RO1; Grant title: Signaling Mechanisms of Focal Adhesion Protein Kindlin-2 in Chondrogenesis; Source: NIH/NIAMS; Term 6/1/2015-5/31/2020; Amount: $2,159,850

Cary Wu, Ph.D. NIH R21; Grant title: A novel kindlin-2 regulatory pathway in bone remodeling; Source: NIH/NIAMS; Term 4/1/2015-3/31/2017; Amount: $383,350

Nahed Ismail, M.D., Ph.D., USDA funding for a project focused

on “comparative genomics of multi-drug resistant

Acinetobacter baumanii in different geographic re-

gions”, 200K/two years ; period 9/1/2015-8/30/2017

KARI NEJAK-BOWEN, Ph.D. received her first R01 (funding started

July 1, 2015); project title is "Role and regulation of beta-catenin in

cholestatic liver disease" (Project Period: 07/01/2015 – 04/30/2020).

$1,125,000 Directs; $607,500 Indirects; $1,732,500 Total award

P A G E 7

I am happy to report that our program continues to do quite well. During the course of the past academic

school year, seven students graduated; however, we also matriculated eight new students (five from IBGP

and three from MSTP), presently putting us at 28 students so that we continue to remain one of the largest

of the six Interdisciplinary Program affiliates. Despite losing some faculty members through career

changes, overall our faculty numbers have been growing. This past academic year we added six new facul-

ty members to CMP: Kari Nejak-Bowen, Stephen Chan, Elena Gonchorova, and Cynthia St. Hilaire

(primary), as well as Sarah Berman and Bryan Brown, (secondary) making our current total 71, up three

from last year at this time. Please remember to tell interested faculty about joining CMP. We are always

willing to add qualified SOM faculty to our graduate program if their interests match with ours.

The specifics of SURP are as follows:

The cost to the individual investigator is $3500.00. In some cases, there may be supplemental funding

from UPSOM. Please contact me at 412-648-9690 or wmars@pitt.edu if you are interested in learning

more about these funding opportunities.

The program will run from May 23-July 29. Students are expected to have a specific project that they

work on full time. They are also expected to attend supplemental programming 1-2 hours a week. At the

end of the experience they must write an abstract and do a 10-minute power point presentation of their

work. Student housing and travel will generously be provided by UPSOM.

The success of this program relies on quality mentors well as quality students. Part of our past success has

been due to participation of interested faculty such as you. In addition, we have implemented several tech-

niques designed to attract the highest quality students to our program such as a shared online application

process. I would venture that many of you who have participated as SURP mentors in the past can attest

to the quality of the students that we are attracting. You need not be graduate faculty to take on a student.

If you have any questions or are willing to be a mentor this year, please contact me at 412-648-9690, or via e-

mail at wmars@pitt.edu. The application process has already begun. Also, remember that if you are interested in

having issues brought before the CMP steering committee, please share them with either our CMP administrator,

Tara Rohall (rohallta@upmc.edu), or with me (wmars@pitt.edu). Thanks so much!

Wendy M. Mars, Ph.D.

Director, Pathology SURP and CMP graduate program

From the desk of Dr. Wendy M. Mars ….

SURP AND CMP GRADUATE PROGRAM

SAVE THE DATES

On May 25, 2016 we will hold our annual Pathology Retreat, combining our basic and clinical research-

ers for an afternoon of stimulating talks, once again followed by a poster session at the University Club.

This year our keynote speaker will be Charles A Parkos, MD/PhD, the Chairman of Pathology at the

University of Michigan.

The Summer Undergraduate Research Program (SURP) will begin early next year, on May 23, 2016. For

SURP, we are once again actively seeking interested faculty willing to host college undergraduates in their la-

boratories for a 10-week scientific research experience. SURP is a highly competitive outreach program, spe-

cifically designed to recruit high quality students into applying for graduate degrees through the University of

Pittsburgh School of Medicine (UPSOM) programs such as the Interdisciplinary Biomedical Graduate Program

and the Medical School.

Residency Program

Appointment of Associate Director

Marie DeFrances has been appointed Associate Director of the Residency Program

effective September 1, 2015. She will report to the Program Director Dr Macpherson

and continues her role in being responsible for the pathology medical school curricu-

lum and activities.

Recruitment for Class starting July 1, 2016

On October 16th the first of 11 interview days was held. Six candidates are invited for

each Friday interview day through January 15, 2016. Candidates are given the oppor-

tunity to request meeting with faculty of their interest. Such meetings will be sched-

uled as per faculty interest and availability Thursday afternoon or late Friday after-

noon. Thank you to those who have already agreed to meet with candidates.

Program Updates

Russ Silowash and Humberto Trejo Bittar have developed an Access based tool called

‘Report Formatting Reference Library’. It enables residents to review de-

identified anatomic pathology reports searchable by organ system, case type or attend-

ing. This is significantly enhancing the preview process for residents prior to sign out

with the attending.

Dr. Pantanowitz has launched a ‘Sandbox Server’ for use by residents to develop in-

formatics software tools as part of their research and education enhancements. An ear-

ly user will be Tom Pearce who is developing a robust on line tool to support and en-

hance the anatomic pathology unknown slide conference.

From the desk of Dr. Trevor Macpherson…..

RESIDENCY AND FELLOWSHIP

P A G E 8

Graduation date is Saturday May 14, 2016. Graduating residents, fellows and clinical in-

structors will be recognized.

Fellowship Program

Dr. Somak Roy has been appointed Associate Director of the MGP Fellowship

Dr. Humberto Trejo Bittar is our Chief Fellow.

Recruitment for fellows for start date July 1, 2017 has commenced.

All ACGME accredited fellowships are required effective July 1, 2016 to implement

their Clinical Competency Committee and Program Evaluation Committee

Congratulations to Sara Wheeler and Dan Rhoads whose young investigator presenta-

tions were two of the three presentations selected as ‘Young Investigator Award with

Distinction at ACLPS meeting.

Heather Metz - CMP Graduate Student

Neutrophil Elastase Promotes Myofibroblast Differentiation in Lung Fibrosis.

Alyssa Gregory, Corrine Kliment, Heather Metz, Kyoung-Hee Kim, Julia Kargl, Brit-

tani Agostini, Lauren Crum, Elizabeth Oczypok, Tim Oury, A. McGarry Houghton.

Presentation:

Heather E. Metz, Stephanie E. Busch, Mark L. Hanke, Julia Kargl, Kyoung-Hee Kim, A.

McGarry HoughtonInsulin Receptor Substrate-1 Regulates Immune Cell Content in

Lung Adenocarcinoma. American Association for Cancer Research International Con-

ference 2015, Pittsburgh, PA.

P A G E 9

P A G E 1 0

From the desk of Dr. Marie DeFrances…..

MEDICAL SCHOOL

Jackie Birkness, a fourth year medical student and an officer of the Pathology Medical

Student Interest Group, and Alex Kikuchi, an MSTP student performing his dissertation

studies in the lab of Dr. Paul Monga, were recently notified that they were chosen to receive

the "Academic Excellence and Achievement in Pathology Award" from the American Society

of Clinical Pathology (ASCP). The ASCP states that many highly qualified candidates made

the selection process difficult. Congratulations, Jackie and Alex!

In other news, three Klionsky Summer Research Fellows (Tani Pollock, Erica Johnson, and

Peter Wu) participated in a new pathology initiative called STEPS (Summer Training

Experiences in Pathology for Medical Students). STEPS was designed to provide second year

medical students with opportunities to observe the clinical practice of Pathology one morning

a week while carrying out summer research in our department. Eight activities were planned

in different subspecialities of pathology such as autopsy, clinical chemistry, blood banking,

and genomic pathology. Thanks to all who helped make STEPS a success!

The School of Medicine held a “Scholarly Research Project Speed Dating” event on October

19 from 5-7 pm to match medical students with research mentors. Faculty who would like to

mentor a medical student Scholarly Research Project should send a brief statement about their

research interest to Suzann Beardsley (suzann@medschool.pitt.edu) .

Please send newsworthy items as they happen to:

szalkuskict@upmc.edu.

Thank you.

RESIDENT PUBLICATIONS

Pradhan D, Roy S, Quiroga-Garza G, Cieply K, Mahaffey AL, Bastacky S, Dhir R, Parwani AV. Valida-

tion and Utilization of a TFE3 Break-apart FISH Assay for Xp11.2 Translocation Renal Cell Carcinoma and

Alveolar Soft Part Sarcoma. Diagnostic Pathology. 2015 Sep 29;10(1):179. PMID: 26415891

Pradhan D, Amin RM, Jones MW, Surti U, Parwani AV. Giant-Cell Arteritis of the Female Genital Tract

with Occult Temporal Arteritis and Marginal Zone Lymphoma Harboring Unusual 20q Deletion – A Case

Report and Literature Review. International Journal of Surgical Pathology. 2015 Sep 9. PMID: 26353853

Pradhan D, Sharma A, Mohanty SK. Cribriform-Morular Variant of Papillary Thyroid Carcinoma – a re-

view. Pathology – Research and Practice. 2015 Oct;211(10):712-6. PMID: 26293799.

Pradhan D, Pattnaik N, Silowash R, Mohanty SK. IgG4- related kidney disease – a review. Pathology –

Research and Practice. 2015 Oct;211(10):707-11. PMID: 26341570

Pradhan D, Arora P, Gami A, Kaur N. Immunoglobin G Kappa Biclonal Gammopathy associated with

Multiple Myeloma, Plasmacytoma and Cast Nephropathy. Journal of cancer research and therapeutics. 2015

Jul-Sep;11(3):660. PMID: 26458669.

Diwaker P, Pradhan D, Garg G, Bisaria D, Gogoi K, Mohanty SK. Uterine Angioleiomyoma: A Rare Vari-

ant of Uterine Leiomyoma - A Case Report and Literature Review. Journal of cancer research and therapeu-

tics. 2015 Jul-Sep;11(3):649. PMID: 26458617

Mohanty SK, Gordon OK, Bose S, Pradhan D, Dadmanesh F. Expression of IMP, CK8/18 and CK 14 in

BRCA-related invasive Breast Carcinomas. The Breast Journal. 2015 Sep 22.PMID: 26390986

PRESENTATIONS

Platform :

Pradhan D, Patadji S, Zhao C. Clinical Significance of Atypical Glandular Cells on Pap Test: Analysis of

Over 3000 Cases of AGC Pap in a Large Academic Hospital. 104th USCAP Annual meeting, March

2015, Boston, MA. (Abstracts of the 104th USCAP (United States and Canadian Academy of Pathology)

Annual Meeting, March 21-27, 2015, Boston, MA. Lab Invest. 2015 Feb;95 Suppl 1:4-530. PMID:

26005736)

Pradhan D, Monaco SE, Parwani AV, Ahmed I, Pantanowitz L. Evaluation of Panoramic Digital Images

using Panoptiq for Frozen Section Diagnosis. Pathology Informatics Summit, May 2015, Pittsburgh, PA.

Posters:

Patadji S, Pradhan D, Zhao C. Significance of HR-HPV Detection in Women with AGC on Pap Test:

Analysis of 1857 Cases From One institute. 104th USCAP Annual meeting, March 2015, Boston, MA.

(Abstracts of the 104th USCAP (United States and Canadian Academy of Pathology) Annual Meeting,

March 21-27, 2015, Boston, MA. Lab Invest. 2015 Feb;95 Suppl 1:4-530. PMID: 26005736)

P A G E 1 1

P. Randhawa, G. Zeng, M. Bueno-Fernandez, A. Salgarkar, A. Lesniak, MS, K. Isse, K. Seyb, A. Perry,

I. Charles, C.Hustus, M. Huang, M.Smith, M. Glicksman. Inhibtion of large T antigen ATPase activity a

potential strategy to develop anti-JCV drugs. Antiviral Research, 2014: 112: 113-119.

P. Randhawa, Diana V. Pastrana, Gang Zeng, Yuchen Huang, Ron Shapiro, Puneet Sood, Chethan Putt-

tarappa, Mel Berger, Sundaram Hariharan, Christopher B. Buck. Commercially available immunoglobu-

lins contain virus neutralizing antibodies against all major genotypes of polyomavirus BK. Am J Trans-

plantation, 2015: 15: 1014-1020.

P. Sood, P. Randhawa, Mehta R, Hariharan H, Tevar A. Donor kidney microthrombi and outcomes of

kidney transplant: a single center experience. Clin Transplant 2015, Mar 4. doi: 10.1111/ctr.12539. [Epub

ahead of print].

Randhawa PS: Immunohistochemistry in kidney disease: a cautionary tale. http://

ajkdblog.org/2014/10/30/immunohistochemistry-in-kidney-disease-a-cautionary-tale/h

Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamaguchi Y, Lu P, Branca MF, Ma C, Prindle T Jr, Mie-

lo S, Pompa A, Hodzic Z, Ozolek JA, Hackam DJ. Breast milk protects against the development of ne-

crotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation

of the epidermal growth factor receptor. Mucosal Immunol. 2015 Apr 22. doi: 10.1038/mi.2015.30.

[Epub ahead of print].

Ozolek JA, Cohen DE, Kool M, Pfister SM, Korshunov A, Bukowinski AJ, Davis AW. Medulloepitheli-

oma with peculiar clinical presentation, stem cell phenotype and aberrant DNA methylation profile. CNS

Oncol. 2015 Jun 29:1-10. [Epub ahead of print].

Niehaus JZ, Good M, Jackson LE, Ozolek JA, Silverman GA, Luke CJ. Human SERPINB12 Is an

Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cyto-

chem. 2015 Jul 28. Epub ahead of print] PMID: 26220980.

Picarsic J, Buryk MA, Ozolek JA, Ranganathan S, Monaco SE, Simons JP, Witchel S, Gurtunca N, Joyce

J, Zhong S, Nikiforova MN, Nikiforov Y. Molecular characterization of sporadic pediatric thyroid carci-

noma with the DNA/RNA ThyroSeq v2 next-generation sequencing assay. Pediatr Dev Pathol. 2015 Sep

14. [Epub ahead of print].

P A G E 1 2

PUBLICATIONS

Hu D*, Gur M*, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I, Wan Y. Interplay between

arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.

Nat. Commun. 6:8419 doi: 10.1038/ncomms9419 (2015) (* co-first author).

Li Z, and Zhao C. Clinicopathological and immunohistochemical characterization of dedifferentiated en-

dometrial carcinoma. Appl Immunohistochem Mol Morphol. 2015 Sep 14. [Epub ahead of print].

Crothers BA, Darragh TM, Tambouret RH, Nayar R, Barkan GA, Zhao C, Booth CN, Padmanabhan V,

Tabatabai ZL, Souers RJ, Thomas N, Wilbur DC, Moriarty AT. Trends in Cervical Cytology Screening

and Reporting Practices: Results From the College of American Pathologists 2011 PAP Education Supple-

mental Questionnaire. Arch Pathol Lab Med. 2015 Jun 5. [Epub ahead of print]

Stoler MH, Austin RM, Zhao C. Point-Counterpoint: Cervical Cancer Screening Should Be Done by Pri-

mary Human Papillomavirus Testing with Genotyping and Reflex Cytology for Women over the Age of

25 Years. J Clin Microbiol. 2015 Sep;53(9):2798-804.

Li Z, Ranade A, Zhao C. Pathologic findings of follow-up surgical excision for radial scar on breast core

biopsy. Human Pathol accepted May 2015

Serdy K, Yildiz-Aktas I, Li Z, Zhao C. The value of Papanicolaou tests in the diagnosis of endometrial

carcinoma: a large cohort from an academic medical center. Am J Clin Pathol. Accepted July 2015

Wang H, Li H, Xing X, Zhao C, Luo B. Genotypic analysis and latent membrane protein 1 expression of

Epstein-Barr virus in extranodal NK/T-cell lymphoma from Northern Chinese patients. Arch Virol. 2015

Aug;160(8):2071-4.

Liang H, Griffith CC, Ma L, Ling B, Feng D, Li Z, Zhao C. The sensitivity of Pap cytology and HPV test-

ing to detect cervical cancer: prior testing results in 178 patients with invasive cervical cancer at a large

general hospital in China. JASC online May 2015

Zheng B, Griffith CC, Yan S, Chen C, Ding X, Yang H, Zhao C. Prior high risk HPV testing and Pap test

results of 427 invasive cervical cancers in China’s largest CAP certified laboratory. Cancer Cytopathol.

2015 Jul;123(7):428-34.

Tao X, Griffith CC, Zhou X, Wang Z, Yan Y, Li Z, Zhao C. History of high risk HPV and Pap test results

in a large cohort of patients with invasive cervical carcinoma: experience from the largest women’s hospi-

tal in China. Cancer Cytopathol. 2015 Jul;123(7):421-7.

Woodard A, Austin MR, Li Z, Beere J, Zhao C (corresponding). Prevalence of HPV16/18 genotypes and

histopathologic follow-up outcomes in women with negative cytology and positive high risk HPV test re-

sults. JASC 2015;4:261-2661.

PUBLICATIONS

P A G E 1 3

Ningappa M, Min J, Higgs BW, Ashokkumar C, Ranganathan S, Sindhi R. Genome-wide association

studies in biliary atresia. Wiley Interdiscip Rev Syst Biol Med. 2015 May 11. doi: 10.1002/wsbm.1303.

[Epub ahead of print] PubMed PMID: 25963027.

Harmon CM, Azzuqa AA, Ranganathan S, Mahmood B, Good M. Mid-Aortic Syndrome in a Preterm

Infant: A Rare Cause of Hypertension. J Pediatr. 2015 May 30. pii: S0022-3476(15)00475-8. doi:

10.1016/j.jpeds.2015.05.007. [Epub ahead of print] PubMed PMID: 26037732.

Ranganathan S, Celik N, Mazariegos G, Sindhi R. Liver allograft fibrosis and minimization of immuno-

suppression. Pediatr Transplant. 2015 Sep 3. doi: 10.1111/petr.12590. [Epub ahead of print] PubMed

PMID: 26333572.

Picarsic J, Buryk MA, Ozolek JA, Ranganathan S, Monaco SE, Simons JP, Witchel S, Gurtunca N, Joyce

J, Zhong S, Nikiforova MN, Nikiforov Y. Molecular characterization of sporadic pediatric thyroid carci-

noma with the DNA/RNA ThyroSeq v2 next-generation sequencing assay. Pediatr Dev Pathol. 2015 Sep

14. [Epub ahead of print] PubMed PMID: 26367451.

Ningappa M, So J, Glessner J, Ashokkumar C, Ranganathan S, Min J, Higgs BW, Sun Q, Haberman K,

Schmitt L, Vilarinho S, Mistry PK, Vockley G, Dhawan A, Gittes GK, Hakonarson H, Jaffe R, Subrama-

niam S, Shin D, Sindhi R. The Role of ARF6 in Biliary Atresia. PLoS One. 2015 Sep 17;10(9):e0138381.

doi: 10.1371/journal.pone.0138381. eCollection 2015. PubMed PMID: 26379158.

PUBLICATIONS

R. Marshall Austin, Agnieszka Onisko. Increased Cervical Cancer Risk Associated with Extended

Screening Intervals after Negative Human Papilloma Virus (HPV) Test Results: Bayesian Risk Estimates

using the Pittsburgh Cervical Cancer Screening Model. Journal of American Society of Cytopathology,

In Press, Available online 21 May 2015.

Agnieszka Onisko and R. Marshall Austin. Dynamic Bayesian Network for Cervical Cancer Screening,

In Peter J.F. Lucas and Arjen Hommersom(eds), Foundations of Biomedical Knowledge Representations,

Springer, pages 223-235, 2015.

Agnieszka Onisko, Allan Trucker, and Marek J. Druzdzel. Prediction

and Prognosis of Health and Disease, In Peter J.F. Lucas and Arjen

Hommersom(eds), Foundations of Biomedical Knowledge Represen-

tations, Springer, pages 193-201, 2015.

P A G E 1 4

Picarsic J, Jaffe R. Nosology and Pathology of Langerhans Cell Histiocytosis. Hematol Oncol Clin North

Am. 2015 Oct;29(5):799-823.

Rollins BJ, Allen CE, Collin M, Jaffe R, Picarsic JL, Rodriguez-Galindo C. Dedication. Hematol Oncol Clin

North Am. 2015 Oct;29(5):xi-xii. d. Epub 2015 Aug 25. PubMed PMID: 26461160.

Johnson WT, Patel P, Hernandez A, Grandinetti LM, Huen AC, Marks S, Ho J, Monaco SE, Jaffe R, Picar-

sic J. Langerhans Cell Histiocytosis and Erdheim-Chester Disease, both with cutaneous presentations, and

papillary thyroid carcinoma all harboring the BRAF(V600E) Mutation. J Cutan Pathol. 2015 Oct 10.. [Epub

ahead of print] PubMed PMID: 26454140.

Picarsic J, Buryk MA, Ozolek JA, Ranganathan S, Monaco SE, Simons JP, Witchel S, Gurtunca N, Joyce J,

Zhong S, Nikiforova MN, Nikiforov Y. Molecular characterization of sporadic pediatric thyroid carcinoma

with the DNA/RNA ThyroSeq v2 next-generation sequencing assay. Pediatr Dev Pathol. 2015 Sep 14.

[Epub ahead of print] PubMed PMID: 26367451

PUBLICATIONS

AK Au, Y Chen, L Du, CM Smith, MD Manole, SA Baltagi, CT Chu, RK Aneja, H Bayır, PM Kochanek & RSB Clark. (2015) Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing brain and in primary cortical neurons in vitro. Biochim. Biophys. Acta (Molecular Basis of Disease) 1852: 1902-1911. doi:10.1016/j.bbadis.2015.06.007

M Kostic, MHR Ludtmann, H Bading, M Hershfinkel, E Steer, CT Chu, AY Abramov & I Sekler. (2015) PKA phosphorylation of NCLX reverses mitochondrial calcium overload and depolarization, promoting survival of PINK1-deficient dopaminergic neurons. Cell Reports 13: 376-386.

Book Chapter

EK Steer, MK Dail & CT Chu. (2016) PINK1 as a sensor for mitochondrial function: Dual roles. In The Functions, Disease-Related Dysfunctions and Therapeutic Targeting of Neuronal Mitochondria. (VK Gribkoff, EA Jonas, JM Hardwick, Editors). John Wiley and Sons, Inc., New Jersey, pp. 240-253.

Thursday, November 26, 2015

P A G E 1 5

Charleen Chu, M.D., Ph.D.

Dendritic mitochondrial homeostasis: A-kinase story, July 1, 2015, Gordon Conference on Parkinson’s

Disease, New London, NH.

Parkinson’s disease genes in dendrite maintenance, August 11, 2015, Academia Sinica, Taipei, Taiwan.

Mitophagy in Parkinson’s disease: Brakes & Accelerators, August 24, 2015, 25th Biennial Meeting of

the International Society for Neurochemistry, Cairns, Australia

SOS: Mitochondrial Distress in Parkinson’s Disease, October 1, 2015, Department of Anesthesiology

and Critical Care, University of Pennsylvania.

Nahed Ismail, M.D., Ph.D.

Plenary Presentation: Type I interferon: Master regulator of inflammasome activation in ehrlichiosis. 27th

anuual meeting of the American Society for Rickettsiology (ASR), June 2015

George K. Michalopoulos, M.D., Ph.D. “Liver Regeneration: Signaling Pathways for Initiation and Termi-

nation”, 3rd Alcohol and Cancer Conference, Crete, Greece, May 29-June 2, 2015.

Jennifer Picarsic, M.D.

Histiocyte Society 31st Annual Meeting, Athens, Greece. 9/28/15 Guest speaker, LCH Symposium: Langerhans

cell histiocytosis of the central nervous system: Challenges in pathologic diagnosis.

Parmjeet Randhawa, M.D.

Next generation sequencing of the T-cell receptor of differentiation of T-cell mediated rejection from BKV

induced inflammation in the kidney. US and Canadian Academy of Patholgy Meeting, Boston, MA.

A Whirlwind Tour of Kidney Transplant Pathology, Temple University School of Medicine, Philadel-

phia, PA, April 17, 2015.

BKV nephropathy: are we making any progress with therapy. American Transplant Congress,

Philadelphia, PA, May 2, 2015.

Novel Approaches to the Pathologic and Virologic Diagnosis of BKV infection. American Transplant

Congress, Phliadelphia, PA, May 5, 2015.

Sarangarajan Ranganathan, M.D.

Ranganathan S . Teratoid Hepatoblastoma—A Clinicopathologic and Immunohistochemical Analysis

with Description of Unusual Variants. 2015 Society for Pediatric Pathology Meeting , March 2015.

Pediatr. Dev Pathol 18; e21, 2015.

McFadden K, Ranganathan S. Clinicopathologic Features of angiomatoid fibrous histiocytoma – a sin-

gle Institutional experience. SPP 2015 Fall Meeting, Toronto, Oct 2015.

PRESENTATIONS

P A G E 1 6

Chengquan Zhao, M.D.

Frozen of ovarian epithelial tumor: diagnostic challenge and pitfall. National Advanced Pathology

Meeting by Beijing 301 Hospital, September 10-13, 2015, Beijing, China

A Practical Approach to Intraoperative Consultation in Breast Lesions. National Advanced Pathology

Meeting by Beijing 301 Hospital, September 10-13, 2015, Beijing, China

Cervical cancer screening hot points: Is negative cervical cancer present? The 2015 Red House Forum.

Shanghai, China, June 20-21, 2015

The introduction of current cervical cancer screening status in the USA. 2015 Chinese Annual Cyto-

pathology Meeting. Hefei, China, June 12-14, 2015.

PRESENTATIONS

FOR ACCESS TO WEB PAGE FOR ECU LOG-ON

ECU data for the academic year July 1, 2015 to June 30, 2016 for collection now. Please be sure your info

is entered via our Department’s web page link.

For faculty with a UPMC network ID, please use this link. Accessing this link off of the UPMC network will

bring up a login prompt: https://epssecure.upmc.com/ECUAdmin/auth/index.cfm

For faculty without a UPMC ID, please use this link: https://epssecure.upmc.com/ECUTrack/index.cfm

These links are also available on the Department of Pathology webpage under links

at:http://path.upmc.edu/links.htm.

From the home page select which ECU activity is to be logged, and whether the activity is for medical or

graduate students. Then fill in all fields on the form with an option for a free-text note at the end. Confirma-

ation will be given and the activity will be entered into the database for submission at the end of the academic

term.

Erroneous and duplicate entries may now be deleted by faculty. From the View Entries page, select entries to

remove via the checkbox, then click the Delete Selected Entries button at the bottom. Those entries will not

appear in reports.

For questions or feedback, please contact Thomas Harper at ISD (harperth@upmc.edu).

Thank you.

P A G E 1 7

Wednesday, November 4, 2015 - 12:00 - 1:00 p.m.

1105AB Scaife Hall

"Small Blue Round Cell Tumors Applying the Advances

Of Molecular Diagnosis in Routine Practice"

Cristina Antonescu, M.D.

Director, Bone and Soft Tissue Pathology

Memorial Sloan Kettering Cancer Center

New York, NY

_____________________________________

ANNUAL TOTTEN LECTURE

Wednesday, November 18, 2015 - 12:00 - 1:00 p.m.

1104 Scaife Hall

"Evolving Classifications of Soft Tissue Tumors"

Christopher Fletcher, M.D.

Vice Chair, Anatomic Pathology

Brigham and Women's Hospital

Professor, Harvard Medical School

Boston, MA

_________________________________________

Wednesday, December 2, 2015 - 12:00 - 1:00 p.m.

1104 Scaife Hall

"Analyzing the Role of Wnt Signaling in Skeletal Develop-

ment and Homeostasis"

Bart O. Williams, Ph.D.

Professor and Director

Center for Cancer and Cell Biology

Van Andel Research Institute

Grand Rapids, MI

_________________________________________

Wednesday, December 9, 2015 - 12:00 - 1:00 p.m.

1104 Scaife Hall

"Transcriptional Control of Bladder Tumor Progression"

David J. DeGraff, Ph.D.

Assistant Professor of Pathology

Division of Experimental Pathology

Penn State Milton S. Hershey Medical Center

Hershey, PA

ANNUAL MARTINEZ MEMORIAL LECTURE

Wednesday, December 16, 2015 - 12:00 - 1:00 p.m.

1104 Scaife Hall

"The Clinicopathologic Spectrum of Neurodegenerative

Tauopathies"

Dennis W. Dickson, M.D.

Robert E. Jacoby Professor of Alzheimer's Research

Mayo Clinic

Jacksonville, FL

________________________________________________

ANNUAL MENTEN LECTURE

Wednesday, January 6, 2016—12:00—1:00 p.m.

1104 Scaife Hall

“Liver Regeneration”

George K Michalopoulos, M.D., Ph.D.

Menten Professor and Chair

Department of Pathology

University of Pittsburgh

_________________________________________________

Wednesday, January 13, 2016—12:00-1:00 p.m.

1104 Scaife Hall

“The Role of Focal Adhesion Kinase in

Hepatocarcinogenesis”

Wei Qiu, Ph.D.

Assistant Professor

Loyola University

Chicago, IL

__________________________________________________

Wednesday, January 20, 2016—12:00—1:00 p.m.

1104 Scaife Hall

“How Hepatocytes Polarize and What Happens When They

Don’t”

Irwin Arias, M.D.

Professor of Physiology Emeritus

Senior Scientist Emeritus, NIH

Bethesda, MD

P A G E 1 8

CME Credit Update

The University of Pittsburgh School of Medicine, Center for Continuing Education for the Health Sciences

CME transcripts can be obtained via the Internet at ccehs.upmc.edu. Click on link “Credit Transcripts” en-

ter the required information (last name, last five digits of social security number). The transcript reflects

the American Medical Association Category 1 credits or the Continuing Education Units (CEUs) which have

been entered into the Center’s database. Credits from other institutions can be entered using the option

“add/modify” credit information. For questions about the Continuing Medical Education Credits, please

contact 412.647.8232.

Educational Credit Unit Update

Just a reminder that the Educational Credit Units (ECUs) are being collected from every faculty member

who has been involved with teaching activities of the medical or graduate school programs from July 1,

2015 to June 30, 2016. We have initiated a web-page (see directions for access to page on Page 17) to

collect teaching as it happens. Please be sure to update your teaching data. The School of Medicine will

be asking for the information in July. If you have any questions please contact Chris Szalkuski at

szalkuskict@upmc.edu.

Publication Notification Process Update

This is a reminder the Dean has requested a Notification of Publication form for each manuscript accept-

ed for publication in a peer-reviewed journal. The notification ensures compliance with human and animal

research policies, technology transfer/patent guidelines and the requirements for citation of grant support.

It also allows for newsworthy publications to be passed onto the University media. Please submit preprint

information via the website at: https://pnf.hs.pitt.edu . If you have any questions, please contact Chris

Szalkuski at szalkuskict@upmc.edu.

P A G E 1 9

Veteran's Day National Remembrance Day Roll Call

November 11, 2015— 1:00pm

The University of Pittsburgh Office of Veterans Services (OVS) celebrates those

who have served and are serving, and remember with gratitude those who gave

all, both within Pitt's student body and throughout the region.

All Pennsylvania service members who have died while serving our country in Iraq and

Afghanistan, will be honored. Visit the Heinz Chapel Website to learn more.