Pathology 430/826 The Molecular Basis of Disease.
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Transcript of Pathology 430/826 The Molecular Basis of Disease.
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Pathology 430/826
The Molecular Basis of Disease
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Path 430/826 - 0.5 creditsCourse Coordinator
David Lillicrap
Room 201G Richardson Laboratory
http://clinlabs.path.queensu.ca/path430/
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Monday 8.30 – 10.30 am
Room 101 Richardson Laboratory
Will need to start at 8.35 am
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Course Format
5 Human Disease Themes
Blood malignancyBleeding diseases
Thrombotic diseasesNeurological disorders
Urological cancer
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Course Instructors
Dr. David Lillicrap Coordinator/Anemia/Thrombosis/Bleeding diseases
Dr. Laura Swystun Bleeding diseases/Thrombosis
Dr. Michael Rauh Blood malignancies
Dr. David Good Blood malignancies
Dr. Harriet Feilotter Neurologic disease
Dr. John Rossiter Neurologic disease
Dr. David Berman Urological Cancer
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Human Disease Themes
1. Common and rare
2. Inherited and acquired
3. Malignant and benign
4. Different organ systems
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Course Objectives
1. To understand the molecular basis of a group of“model” human diseases (molecular pathogenesis).
2. To gain insights into diagnostic and therapeutic strategies for human disease.
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Human Disease Pathology/Pathogenesis
Diagnosis of Disease
Treatment of Disease
Central Place of Disease Mechanisms
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Human Pathology - Disease
Genetics
ImmunologyBiochemistry
Molecular biologyHistology
Microbiology
Diagnosis and Therapy
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Week 1
1. Introduction to Path 430-826/Evaluations/Expectations
2. Introduction to Molecular Medicine/Personalized Medicine
3. A highly prevalent inherited disease – Thalassemia
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Week 2
Introductory background to blood malignanciesLymphoma/leukemia
~40 mins - Then 10 min break
Student Presentation #1
20 mins + 15 mins discussion/questions
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Week 3
2 X 20 minute students presentations
~15 mins discussion/questions per presentation
Leukemia/Lymphoma - introductory presentation (~30 mins)
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Evaluative Components
Path 430 and Path 826
1 oral presentation 30%
1 Term paper 50%
Course Participation 20%
No mid-term or final exam
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Term Paper Choice and Format
• 5 paper titles will be distributed just before Reading Week
• 10 pages – double spaced, not including figures/references
• Include at least 1 figure and 15 references
• Return by Monday April 4th 2016 at 4pm.
Path 430
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Term Paper Choice and Format
• 1 paper title will be available by Reading Week
• 12 pages – double spaced, not including figures/references
• Include at least 2 figures and 25 references
• Return by Tuesday April 4th 2016 at 4pm.
Path 826
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Student Presentations• No longer than 20 mins
• No more than 30 slides
• Focus on• Brief background• Study objectives• Overall study results• Study conclusions• Any study limitations/weaknesses
Do not get distracted/confused by the minutia of results
Better to present a clear representative example from the data - ie. several illustrative graphs or figures
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Course Participation
• Expectation that everyone in class has read some of theassigned papers, and can ask relevant questions about the work.
• Each week, every student will be expected to hand to the Course TA, 2 questions pertinent to the papers being presented. Two or three of these questions will be asked during the class.
• In addition, for each paper presentation, two students will be asked at random (everyone will be asked equally over the term)to either comment on a weakness of the work, or to ask the presenter a question.
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Course Expectations1. Possession of a good background knowledge of the biological
sciences
2. Show an interest in furthering this knowledge
3. Class involvement –
interest in discussion
responses to questions
4. Demonstrate the ability to communicate scientific knowledge, both orally and in writing, in a clear, precise and succinct manner.