Patho- PUD.ppt

7/23/2019 Patho- PUD.ppt

1/15

GROUP 2-H.E.I

PATHOPHYSIOLOGIC

BASIC OF PUD


2/15

Ulcersare defined as breaks in the

mucosal surface>5 mmin size, with

depth to thesubmucosa


3/15

EPIDEMIOLOGY


4/15

PATHOLOGY


5/15

H.PYLORI AND PEPTICACID DISORDER


6/15

THE BACTERIUM

What do you know about H.pylori?

- Gram?

- How can it survive in the acidic environment of

the stomach?


7/15

THE BACTERIUM

gram-negative microaerophilic

deeper portions of the mucous gel coating the

gastric mucosa or between the mucous layer and

the gastric epithelium.S-shaped (~0.5 x 3 m in size)

sheathedflagella

Produce urease. Ure -> Amonia : alkanizing


8/15

EPIDEMIOLOGY

Standard of livingRate of infection: decrease in industrializedcountries

Risk factors of H.p infection:

1/ Poor socioeconomic status

2/ less education

3/ birth or residence in a developing country

4/ domestic crowding

5/ unsanitary living conditions

6/ unclean food or water

7/ exposure to gastric contents of an infectedindividual


9/15

EPIDEMIOLOGY:

How do H.p transmit?

Person to person by oral- oral route or fecal- oral

route


10/15

PATHOPHYSIOLOGY


11/15

PATHOPHYSIOLOGY


12/15

NSAIDS


13/15

EPIDEMIOLOGY

the most commonly used medications in the

United States

Complications: nausea, dyspepsia -> ulcerations,

perforation

Even 75 mg/d of aspirin may lead to serious

gastrointestinal ulceration; thus, no dose of

NSAID is completely safe.


14/15

Established risk factors:

include advanced age

history of ulcer

concomitant use of glucocorticoids

high-dose NSAIDs

multiple NSAIDs

concomitant use of anticoagulantsserious or multisystem disease

Possible risk factors:

concomitant infection withH. pylori

cigarette smoking

alcohol consumption.


15/15

PATHOPHYSIOLOGY

Patho- PUD.ppt

Documents

Transcript of Patho- PUD.ppt