Parasitic Infections in Central Nervous System Saleha...
Transcript of Parasitic Infections in Central Nervous System Saleha...
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Parasitic Infections in Central Nervous System
Saleha Sungkar
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Malaria
• Aetiology: - P. falciparum- P. vivax- P. malariae - P. ovale• Trias: fever, anemia
and splenomegaly
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Plasmodium falciparum- Its specific behaviour: sequestration
(mengasingkan diri) in deep capillary for schizogony and gametogony process
- Sequestration in brain, lung, heart, liver, kidney, etc Sequestration forms sludge and inhibits micro-circulation temporary organ dysfunction/ failure. If patients are cured in this stage, no sequel is observed
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Parasite` sequestration
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Parasite` sequestration
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Pathogenesis of Cerebral Malaria
• Capillary obstruction mechanism:– Rosetting (erythrocyte segregation )– Cytoadherence (erythrocyte adherence to
endothel)• Impaired delivery substrate: hypoglycaemia,
hypoxia, anemia• Endotoxin mechanism: NO, cytokines, etc• Clotting coma, seizures, hyperpyrexia
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Malaria diagnosis• To find parasite or parasite product in
blood circulation: Plasmodium spp live in erythrocyte, by
making thick and thin blood smear, morphologically plasmodium could be differentiated according to the species
(Giemsa, QBC)• P. falciparum Antigen Detection• Detection DNA or RNA parasite
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Neurosistiserkosis
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Important species in Indonesia
• Taenia saginata; intermediate host: cow• Taenia solium; intermediate host: pig, dog
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Life Cycle Undercooked meat
+ cysticercus
cysticercus evaginated in human small intestinal
scolex + neck
Immature proglotid
mature proglotid
Gravid proglotid expelled
Eggs in faeces
Intermediate host
cysticercus
}
Taeniasis
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Distribusi Taeniasis/Sistiserkosisdi Indonesia
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Cysticercosis• aetiology:
cysticercus cellulosae (larvae of the tapeworm T. solium)
• Larvae are acquired by ingestion of T. solium ova
Microscopically can not be differentiated between T. saginata and T. solium
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Cysticercus : a white opalescent vescicle, ovoid to round, measuring 8-15 mm x 5-8 mm containing only one protoscolex May infect many organs (subcutaneous tissue, brain, eye, muscles).
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Cysticercosis:
• the onchospheres migrate to the tissues and develop to cysticerci
• the cysticercus dies and becomes calcified depend on location of the larvae:
- subcutaneous - eye- muscle- cerebral tumor
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Pathogenesis of Neurocysticercosis
• mechanical compression & damage of tissue e.g. granuloma
• immunopathological eg cellular infiltration
• late secondary sequelae of cysticercosis e.g. fibrotic scar
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Clinical Manifestions
• epilepsy• cerebellar ataxia• sensory defect• acute onset of focal seizures• less common: hemiparesis, visual
changes and sensory disturbances• no fever
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Risk Factors
• Immigrant from endemic area • poor sanitation, use of sewage for
fertilizer and lack of controlled pens for pigs
• Contact with other household member who often travel to endemic area (carrier)
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Pig, intermediate host of T. solium
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PROSMISCUOUS DEFAECATION
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Playing at dirty places
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Diagnosis• Microscopic: to find Taenia egg examine
stools for ova & parasites (3 consecutive days) • Serology: antibody detection by enzyme-
linked immunotransfer blot (EITB) and ELISA • Radiology: 1. CT scan shows the cyst (solitary or multiple
and usually 5-20 mm in diameter) and granuloma stages of neurocysticercosis. Most often in the cortex / gray-white junction.
2. Magnetic resonance imaging
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Toxoplasmosis• Mode of infection:- ingestion of cyst in
raw meats- ingestion of oocyst
(in cat faeces)- transplacental- transfusion- organ
transplantation- laboratory accident Toxoplasma gondii
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Organ damage
• depends on host age, virulence and organ infected (CNS and eye: more severe)
• CNS: - meningoencephalitis- brain abscess (multiple)- aquaductus sylvii congestion
hydrocephalus- intracranial calcification- mental and motoric retardation
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Acquired Toxoplasmosis
• Rarely detected (asymptomatic)• Lymphadenopathy (self limiting)• Fever, headache, myalgia, sore throat,
hepatosplenomegaly• Retinochoroiditis• Myocarditis • Encephalitis
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Congenital ToxoplasmosisDisease in Infants
• Normal at birth• Hepatosplenomegaly• Icterus• Lymphadenopathy• Erythroblastosis• Hydrops foetalis• Death: 5% - 15%• Classic triad
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Classic triad1. Hydrocephalus2. Intracranial
calcification3. Retinochoroiditis:
atrophy of retina & choroid
pigmentation4. + Psychomotoric
retardation Tetrade Sabin
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Toxoplasmosis Serology
Acute toxoplasmosis:• Serial blood exam: IgG increase
significantly after 3 weeks or more (4 fold)• Conversion: negative to positive• IgG and IgM in neonatal blood• Polymerase chain reaction
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Amebic Brain Abscess• Aetiology: Entamoeba histolytica• usually occurs in the framework of systemic
amebiasis • fewer than 10% of patients with a hepatic
amebic abscess have cerebral amebiasis • the cerebral abscesses are usually multiple
with accompanying cerebral edema. • abscesses are most commonly located in
the cerebral hemisphere, although a cerebellar location is not infrequent
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chronic amoebiasis colitis ↓
portal vein↓
amebic lever abscess ↓
hematogenous spread↓
pulmonary amoebiasis abscess↓
brain abscess
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Clinical manifestations• usually preceded by gastrointestinal or
hepatic or respiratory symptoms. • an abrupt onset of mental status change
and/or focal neurologic deficits, headache, nausea, vomiting, delirium, coma, sensorial alteration
• meningitis can occur• cranial nerve involvement is frequent• death occurs over 12-72 hours without
adequate therapy
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Diagnosis
• Serologic tests, such as IFA, ELISA, for specific antibodies to E. histolytica are very helpful in diagnosis of invasive amebiasis
• Computed tomograph (CT) and nuclear magnetic resonance (NMR) for the brain abscess
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Free living amoeba
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Naegleria fowleri
• Infect immunocompetent host• Infective stage: the trophozoites• Mode of infection:
1. through the olfactory neuroepithelium2. nasal passages when water is forced into the nose via diving or jumping or submerged underwater
• Trophozoites are found in cerebrospinal fluid and tissue
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Primary Amebic Meningoencephalitis (PAM)
• an acute, a deadly disease of the brain characterized by necrotizing and haemorrhagic meningoencephalitis
• symptoms usually occurs 3-7 days after infection
• aetiology: Naegleria fowleri • epidemiology: individuals with warm water
related activities, diving in the river, summer time
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Clinical features• Fever• Sore throat• Swelling in nose• Severe headache• Stiff neck and back• Nausea, vomiting• Confusion, seizures
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Diagnosis
• Microscopic examination• Culture• Immunofluorescent antibody• Polymerase chain reaction
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Granulomatous Amebic Encephalitis
• Aetiology: Acanthamoeba sp (A.castellani, A.polyphaga, A.culbertsoni) free living amoeba capable of causing subacute or chronic in individuals with imunocompetent and compromised and also in animals
• The trophozoites and cysts are the infective forms entry into the body through the lower respiratory tract, ulcerated or broken skin and invade the central nervous system by hematogenous dissemination
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Clinical features• Subfebris• Headache• Altered mental status• Stiff neck• Nausea and vomit• Focal neurologic deficit which progresses
over several weeks to death
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Trypanosomiasis
1. T. rhodesiense Vektor: Glossina morsitans
2. T. gambienseVektor: Glossina palpalis
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African trypanosomiasis
• Chancre trypanosoma on port d’ entrée
• Fever• Hepatosplenomegaly• Lymphadenopathy
(winter bottom sign)• Meningoencephalitis:
apathy, lethargy, coma and death (T.rhodesiense more virulent)
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Sleeping sickness
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American trypanosomiasis/Chagas disease
• .• caused by T.cruzi • amastigot forms in macrophages on port d’ entrée• granuloma formation• unilateral orbital edema and conjunctivitis (romana sign)
Triatoma
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American trypanosomiasis/ Chagas disease
• Hepatosplenomegaly, generalized lymphadenopathy
• Myocarditis• Meningoencephalitis, ganglion cell
disruption and autonomic function loss resulting in megaesophagus and megacolon
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Diagnosis
1. Finding the parasite (biopsy, blood examination, etc)
2. Culture3. Inoculation / xenodiagnosis4. Immunological reactions5. PCR
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Wassalamualaikum
Terima Kasih