Paper Gerd

7/25/2019 Paper Gerd

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FARDAH AKIL

CLINICAL PICTURES & PREDISPOSITION FACTORS

IN PATIENTS WITH EROSIVE AND NON EROSIVE

GASTROESOPHAGEAL REFLUX DISEASE


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INT O UCTION

Gastroesophageal reflux (GERD) is a disease with

heterogenicity feature, already known but usually is

annoyed

GERD appear if refluxate come into oesophagus with

enough amount and time so that could stimulate mucosa

symptoms wout mucosal damages (esophagitis)

GERD ha!e !arious of clinical symptoms, where

heartburnwout regurgitationreflux as spesific symptoms,

beside dyspepsia and extraesophageal symptoms


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"ased on upper endoscopy patients with heartburn or

GERD can subdi!ided into # catagories $ those with orwithout erosi!e esophagitis

%re!alence of GERD #&' on adult, male is e*ual with

female (gender analysis)

EGERD + with mild stage, male female - #'.$&

%atophysiology and pathogenesis of GERD were

multifactorial, initially in esophagus, gastroesophageal

/unction, gastroduodenal 0 genetic


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%rogression of GERD is influenced by an interplay betweenendogen and exogen factors

1n 2sia symptom of GERD not se!ere, /ust in 3ERD setting

4ohort analysis in 5apan $ mild EGERD to se!ere EGERD &678,

"arrett oesophagus 9 with predisposition factors $ older age,

female, initial symptoms when diagnosed with endoscopy

examination, hiatal hernia 9, atropic gastritis 0 :7pylori infection

;imited data in 1ndonesia < =yafruddin (&>>?) $ esofagitis ##7?in dyspeptic patients


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4apability of endoscopy to diagnose EGERD $ high

sensiti!ity 0 specificity, to e!aluate population pre!alence

not common

GERD incidence is difficult to assess


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PURPOSE

To determine the distribution of

endoscopic result, factor associated andclinical variation of symptoms among

GERD patients undergoing upper

gastrointestinal endoscopy


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SUBJECT AND METHODS

@bser!ational study with cross sectional approach in!ol!ing dyspeptic patients in #

teaching hospital in Aakassar

=tudy was conducted between #666 3o!ember to

#66 @ctober


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2ll sub/ects were *uestioned in regard to clinical symptoms

before endoscopic examination

Diagnosis 0 classification of reflux esophagitis was based

on the ;2 4lassification

2bsence of reflux esophagitis with typical symptoms of

GERD was diagnosis as ha!ing 3ERD


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Erosi!e and 3on'erosi!e GERD were analysed

in relation to age, gender, and some of

predisposition factors $ hiatus hernia, coffe

drinking, smoking and the used of 3=21D


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RESULT

Of 1290 dyspeptic patients, 540 (41.9%)

were diagnosed as having G!" #ased ontypica$ syptos of G!"


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Bable &74haracteristics of GERD patients


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Babel #7 Distribution of endoscopic results in GERD patients

C GERD - Gastroesophageal reflux disease, EGERD - Erosi!e GERD, 3ERD - 3on erosi!ereflux disease


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C GERD - Gastroesophageal reflux disease, EGERD - Erosi!e GERD, 3ERD - 3on erosi!e

reflux disease p 67686 significant

Bable .7 Distribution of GERD patients by gender


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Bable 7 Distribution of GERD patients by age

C GERD - Gastroesophageal reflux disease, EGERD - Erosi!e GERD, 3ERD - 3on erosi!e

reflux disease p+ 6768


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!

"

#

$

%

&

'one (ile reflu) Erosif Ulcer Gastriccancer

'ERD

EGERD

Graphic &7 Findings of gastric lesions in GERD patients


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Babel 87 %redisposisition factors of GERD patients

EGERD - Erosi!e GERD, 3ERD - 3on erosi!e reflux disease, 3=21D - 3on steroid anti inflammation drugs

p+ 67686


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Graphic #7 =ymptoms pattern of GERD patients with reflux as a common

symptom


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Graphic .7 Distribution of symptoms pattern of GERD patients


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CONCLUSION

3ERD constituted larger proportion and mostlyseen in female while EGERD was commonly inmale

=ymptoms pattern between EGERD dan3ERD are identical

Bhe findings of gastric lesions was found toha!e relationship with GERD symptom


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EGERD in patients with GERD in

Aakassar was found higher and ma/ority

case was grade 2 0 "

=ome of predisposition factors in this

study are not associated in the se!erity of

GERD


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