PANCREATITIS SAI YAN AU CHEE SIONG KOH. INTRODUCTION Mrs Emilie Rezek, a 78 years old elderly...
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Transcript of PANCREATITIS SAI YAN AU CHEE SIONG KOH. INTRODUCTION Mrs Emilie Rezek, a 78 years old elderly...
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PANCREATITISPANCREATITIS
SAI YAN AUSAI YAN AU
CHEE SIONG KOHCHEE SIONG KOH
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INTRODUCTIONINTRODUCTION
Mrs Emilie Rezek, a 78 years old Mrs Emilie Rezek, a 78 years old elderly female, presents with an elderly female, presents with an hour’s history of severe epigastric hour’s history of severe epigastric pain radiating to the back.pain radiating to the back.
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PAST HISTORYPAST HISTORY
““Bad turn” of the heart about 1 month agoBad turn” of the heart about 1 month ago Admitted to RHH and had a cardiac stentingAdmitted to RHH and had a cardiac stenting On a background of chest pain 6 to 7 years On a background of chest pain 6 to 7 years
ago ago Exertion inducedExertion induced On medication – LoprexOn medication – Loprex Worsening over the 6 to 7 yearsWorsening over the 6 to 7 years
Acute Myocardial Infarction 10 years agoAcute Myocardial Infarction 10 years ago
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Long standing stomachache Long standing stomachache (DYSPEPSIA) – gastroscopy in 1994(DYSPEPSIA) – gastroscopy in 1994
CholecystectomyCholecystectomy On ZoloftOn Zoloft
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No hypertensionNo hypertension No diabetes mellitusNo diabetes mellitus No asthma and epilepsyNo asthma and epilepsy NKANKA
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PRESENTING PRESENTING COMPLAINT(PC)COMPLAINT(PC)
EPIGASTRIC PAINEPIGASTRIC PAIN
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HISTORY OF PCHISTORY OF PC
EPIGASTRIC PAINEPIGASTRIC PAIN Started 1 day after discharge from RHHStarted 1 day after discharge from RHH Was sleeping at time of attackWas sleeping at time of attack Lasted for 15 min and spontaneous Lasted for 15 min and spontaneous
resolve for 10 min and started again – resolve for 10 min and started again – call for ambulancecall for ambulance
Ripping pain on a scale of 6/10(1Ripping pain on a scale of 6/10(1stst episode) and 10/10( 2episode) and 10/10( 2ndnd episode) which episode) which radiates to the backradiates to the back
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EPIGASTRIC PAINEPIGASTRIC PAIN No relieving or aggravating factorsNo relieving or aggravating factors Other associated features includes Other associated features includes
shortness of breath, nausea and shortness of breath, nausea and perspiration(diaphoresis)perspiration(diaphoresis)
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FAMILY HISTORYFAMILY HISTORY
Father died in world war II – Father died in world war II – traumatic injuries traumatic injuries
Mother died in world war II – Mother died in world war II – marrow problemmarrow problem
Has 3 sons:Has 3 sons: One has heart diseaseOne has heart disease One died of traumatic injuriesOne died of traumatic injuries One is a/wOne is a/w
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SOCIAL HISTORYSOCIAL HISTORY
Came from Prague in 1949 with husbandCame from Prague in 1949 with husband Lives alone since death of husbandLives alone since death of husband Able to cook and clean the house until 2 Able to cook and clean the house until 2
months ago when shortness of breath months ago when shortness of breath worsenedworsened
Non smoker Non smoker Non drinkerNon drinker Has a dogHas a dog
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SYSTEMIC REVIEWSYSTEMIC REVIEW
Cardiovascular systemCardiovascular system Chest pain Chest pain Shortness of breath of few years Shortness of breath of few years
worsened 2 to 3 months agoworsened 2 to 3 months ago No palpitation No palpitation No PNDNo PND
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GastrointestinalGastrointestinal Vomiting for 3 to 4 times for past 2 Vomiting for 3 to 4 times for past 2
monthsmonths Constipated for past 2 months – goes to Constipated for past 2 months – goes to
toilet every 3 daystoilet every 3 days No loss of appetiteNo loss of appetite No loss of weightNo loss of weight No diarrhoeaNo diarrhoea Good energy statusGood energy status
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CardiovascularCardiovascular Chest painChest pain Shortness of breath worsened 2 to 3 Shortness of breath worsened 2 to 3
months agomonths ago No palpitationNo palpitation No PNDNo PND
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Other systemsOther systems No positive findingsNo positive findings
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CLINICAL EXAMINATIONCLINICAL EXAMINATION
Elderly ladyElderly lady Not cyanosed or jaundicedNot cyanosed or jaundiced Non cachecticNon cachectic AfebrileAfebrile Heart rate - 76/min, regular rhythmHeart rate - 76/min, regular rhythm Blood pressure - 140/80 mmHgBlood pressure - 140/80 mmHg Respiratory rate - 20/minRespiratory rate - 20/min
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Positive findings : -Positive findings : - GITGIT
Right cholecystectomy scarRight cholecystectomy scar Right upper quadrant tendernessRight upper quadrant tenderness Non distended abdomenNon distended abdomen No organ enlargementNo organ enlargement No enlarged lymph nodesNo enlarged lymph nodes No palpable massNo palpable mass No ascites No ascites No renal bruitNo renal bruit Bowel sound presenceBowel sound presence
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CVS, RESPI, MSK, GUT, HAEMO, CVS, RESPI, MSK, GUT, HAEMO, ENDO AND NEURO – no abnormal ENDO AND NEURO – no abnormal findingsfindings
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DIFFERENTIAL DIAGNOSISDIFFERENTIAL DIAGNOSIS
PancreatitisPancreatitis Peptic ulcer disease ?Peptic ulcer disease ? Acute Myocardial Infarction ?Acute Myocardial Infarction ?
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LOCATION OF PANCREASLOCATION OF PANCREAS
Elongated structure that lies in the epigastrium and the left upper Elongated structure that lies in the epigastrium and the left upper quadrant.quadrant.
Soft, lobulated and situated on the posterior abdominal wall Soft, lobulated and situated on the posterior abdominal wall behind the peritoneum.behind the peritoneum.
Crosses the transpyloric planeCrosses the transpyloric plane Divided into a head, neck, body, and tail.Divided into a head, neck, body, and tail.
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THE PANCREASTHE PANCREAS
Here is the normal gross appearance of the adult pancreas; a small Here is the normal gross appearance of the adult pancreas; a small portion of duodenum is at the left next to the head; the tail of the portion of duodenum is at the left next to the head; the tail of the pancreas is at the right. The pancreas has a tan, lobular architecture. pancreas is at the right. The pancreas has a tan, lobular architecture. Adjacent adipose tissue and lymph nodes are closely apposed. Adjacent adipose tissue and lymph nodes are closely apposed.
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PANCREATITISPANCREATITIS
Definition : -Definition : - An inflammatory disorder of the An inflammatory disorder of the
pancreas pancreas Characterized by abdominal painCharacterized by abdominal pain Attacks range from mild to severeAttacks range from mild to severe Can occur as acute form (acute Can occur as acute form (acute
pancreatitis), recurrent acute form pancreatitis), recurrent acute form (chronic relapsing pancreatitis) and (chronic relapsing pancreatitis) and persistent (chronic pancreatitis)persistent (chronic pancreatitis)
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ACUTE PANCREATITISACUTE PANCREATITIS
Mild, self -limited, and more seriousMild, self -limited, and more serious Female > maleFemale > male Peak incidence - between 50 to 60 YOPeak incidence - between 50 to 60 YO Most common causes - gallstones, Most common causes - gallstones,
alcoholalcohol Other causes - iatrogenic or traumatic, Other causes - iatrogenic or traumatic,
metabolic, infection and idiopathicmetabolic, infection and idiopathic
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Pathophysiology : -Pathophysiology : - Sudden onset of diffuse inflammationSudden onset of diffuse inflammation Acute haemorrhage Acute haemorrhage Causes extensive necrosis of the organCauses extensive necrosis of the organ
Clinical features : -Clinical features : - Mild attackMild attack Moderate attack Moderate attack Severe attackSevere attack
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This is an example of acute pancreatitis. The pancreas is This is an example of acute pancreatitis. The pancreas is swollen and does not show the typical tan, lobulated swollen and does not show the typical tan, lobulated architecture. Instead, it has areas of hemorrhagic necrosis that architecture. Instead, it has areas of hemorrhagic necrosis that appear as blotchy black red areas at the mid right of the appear as blotchy black red areas at the mid right of the photograph.photograph.
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Mild attackMild attack Acute abdominal painAcute abdominal pain Minimal/rapidly resolving abdo signsMinimal/rapidly resolving abdo signs Minimum systemic illnessMinimum systemic illness
Moderate attackModerate attack Severe acute abdo painSevere acute abdo pain TachycardiaTachycardia Abdo distension, tenderness and Abdo distension, tenderness and
guardingguarding
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Severe attacksSevere attacks Severe acute abdominal painSevere acute abdominal pain Severe toxaemia and shockSevere toxaemia and shock Generalised peritonitisGeneralised peritonitis ARDSARDS
Reference : Essential Surgery, Burkitt,Quick and Gatt, 2nd Edition, page 275
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INVESTIGATIONSINVESTIGATIONS
Serum amylase level ( >1200 Serum amylase level ( >1200 i.u/mL)i.u/mL)
Liver Function Tests (ALT) – raised 3 Liver Function Tests (ALT) – raised 3 times more than normal in gallstone times more than normal in gallstone pancreatitispancreatitis
Plain x – rays of chest ( erect ) and Plain x – rays of chest ( erect ) and abdomen ( supine )abdomen ( supine )
ERCPERCP Peritoneal tapPeritoneal tap
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MANAGEMENT MANAGEMENT
““NIL by mouth” and I/V fluidsNIL by mouth” and I/V fluids Nasogastric aspirationNasogastric aspiration Broad - spectrum I/V antibioticsBroad - spectrum I/V antibiotics Intensive careIntensive care
Fluild and electrolyte managementFluild and electrolyte management Treatment of hypocalcaemiaTreatment of hypocalcaemia Ventilatory supportVentilatory support
surgerysurgery
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CHRONIC PANCREATITISCHRONIC PANCREATITIS
Continuous or relapsing Continuous or relapsing inflammation of the pancreas inflammation of the pancreas leading to irreversible morphologic leading to irreversible morphologic damage and permanent damage and permanent impairment of functionimpairment of function
Etiology – alcohol, gallstonesEtiology – alcohol, gallstones Pathophysiology : -Pathophysiology : -
Loss of pancreatic parenchymaLoss of pancreatic parenchyma Replacement by fibrous tissueReplacement by fibrous tissue
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Clinical features : -Clinical features : - Persistent and severe upper Persistent and severe upper
abdominal painabdominal pain Steatorrhoea, vomiting, abdo Steatorrhoea, vomiting, abdo
distension and progressive weight distension and progressive weight loss.loss.
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INVESTIGATIONINVESTIGATION
Serum amylaseSerum amylase Ultrasound Ultrasound Abdominal x-rayAbdominal x-ray CT scanCT scan ERCPERCP
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MANAGEMENTMANAGEMENT
Medical interventionMedical intervention Treat the painTreat the pain Maintain nutritional statusMaintain nutritional status Reduced symptomsReduced symptoms
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SurgerySurgery Removal of pancreatic duct stonesRemoval of pancreatic duct stones Partial pancreatectomy of the head Partial pancreatectomy of the head
and tailand tail Sphincteroplasty of the pancreatic Sphincteroplasty of the pancreatic
duct openingduct opening