Palestra pgf ppartointerveting-alexei
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Reduction by 95% of the weight (approx. 8-9kg) in 20-25 days
How does it happen?
1. Through lochia (20%)Shedding of caruncles
2 – Absorption (80%)Similar to inflammatory process
Retrospective view on the use of prostaglandins in post partum
Started with the treatment of calving problems (since 1978)
Later verified with the information that the treated animals apart from showing clinical improvement also returned earlier to reproductive activity (1987)
* Significativo pelo teste de ‘t’ a 5% de probabilidade
Efficacy of the treatment of placental retention with oxytetracycline HCl with or without simultaneous administration of cloprostenol (Fernandes, 1999)
Variable Oxytetracycline HCl
Oxyt+ Cloprostenol
Number of animals 90 90Infection at 30d post partum (%) 44,4 42,2Degree of uterine involution* (%) 1,92 2,43Interval calving-to-conception (d)* 78,4 54,1Breeding period (d)* 131,3 111,7Services/conception 2,41 2,03
Retrospectiva da utilização de prostaglandinas no pós-parto
Started with the treatment of calving problems (since 1978)
Later verified with the information that the treated animals apart from showing clinical improvement also returned earlier to reproductive activity (1987)
Relationship between uterine involution and resumption of ovarian activity (1993)
Use in animals without calving problems (2002)
Effects of Ciosin® administered during post partum in various scientific studies in comparison to a control group
Author Number of females
Reduction in post calving interval (d)
Breed
Fernandes, 2002 217 32,0 Holandês
Zanchet,2004
159 38,7Holandês
Zanchet,2004
227 32,5Jersey
Fernandes,2004
190 17,3Nelore (primíparas)
Fernandes,2004
295 12,2Nelore (multíparas)
Fernandes,2006 320 14,7
Vacas mestiças
Silveira 2008 78 12,3 Bufalos
Uterine involution The process of absorption relies
on a mechanism similar to inflammation
Chemical mediators involved are also similar
Derivatives of arachidonic acid, principally prostaglandins are among the most important
Take care when using anti-inflammatory drugs
Uterine size and involution speed according to the number of days post partum
More than 50% of the involution takes place within the 1st week Higher production of PGF and
related substances Increase in the number of
receptors for PGF and analogues
1 5 10 15 20 25 30
Uterine Size
Dayss Post partum
Group Treatment scheme
ControlAdministration of one dose of 2ml physiological solution, intramuscularly, at 2 days post partum
Group 2Administration of 0.530mg cloprostenol (Ciosin®) in a single dose, intramuscularly, at 2 days post partum
Group 3Administration of 0.530mg cloprostenol (Ciosin®), intramuscularly, at 2 days post partum. Second dose administered at 3-5 days post the 1st dose
Effect of cloprostenol sodium administered post partum in dairy cows and resumption of reproductive activity (Fernandes et al., 2002ab)
Treatment scheme in post partum animals
Degree of uterine involution, assessed through rectal palpation at 30d post partum in different treatment groups (Fernandes et al.
2002)
Degree of Involution 1 – Palpation possible
only of the tips of uterine horns
2. Palpation of more than half of the uterine body possible within the abdominal cavity
3. More than half of the uterus located in the pelvic cavity
P<0,05 Between Control and Ciosin 2x
Average incidence of puerperal uterine infections in dairy cows treated with cloprostenol sodium in post partum period (Fernandes et al. 2002)
Effect of PGF1. Mechanical – reduction of uterine volume and expulsion of the lochiae2. Direct effect of PGF on the activity of cells forming the uterine immune defense
P<0,05 Between Control and Ciosin 2x
Number of services per conception in cows treated with cloprostenol sodium post partum (Fernandes et al. 2002)
P>0,05
Reproductive performance of cows treated with cloprostenol sodium post partum (Fernandes et al. 2002)
P<0,05 Between Goups 1 and 3
Treatment scheme in post partum animals
Group NoGroup
descriptionTreatment scheme
Control 120 Control2ml of physiological saline intramuscularly, two doses
Group 2 120Cloprostenol – 1st week
Two doses of 0.530mg cloprostenol, intramuscularly, during the first week pp, with interval of 2-3 days
Group 3 120Cloprostenol – 3rd week
Two doses of 0.530mg cloprostenol, intramuscularly, during the third week pp, with interval of 2-3 days
Esquema de tratamento dos animais após o parto
GRUPO N Descrição
Controle 120 Sem tratamento
Clorp 2x – 1ª Sem 120
Duas doses de 0,530mg de Cloprostenol via intramuscular, na
1ª semana pós-parto, com 2 a 3 dias de intervalo
Clorp 2x – 3ª Sem 120
Duas doses de 0,530mg de Cloprostenol via intramuscular, na
3ª semana pós-parto, com 2 a 3 dias de intervalo
Efeitos do cloprostenol em diferentes períodos no pós-parto de vacas leiteiras (Camargos e Fernandes,
2009)
Effects of cloprostenol administered at different times during post partum period in dairy cows (Camargos e
Fernandes, 2009)
P<0,05 Between Control and 1st Week
Treatment scheme in post partum animals
Effect of different cloprostenol (Ciosin®) doses administered in post partum in beef cows (Fernandes et
al, 2007)
Treatment groupNumber of
animalsTreatment description
Control 130 No treatment
Clopr 2ml 132A single dose of 0.530mg cloprostenol (Ciosin®), intramuscularly, within the
first 2 days post calving
Clopr 4ml 136
A single dose of 1.060mg cloprostenol (Ciosin®), intramuscularly, within the
first 2 days post calving
Average interval calving-to-1st AI, cumulative and in different production sites and treatment groups
(Fernandes et al., 2007) (Fernandes et al., 2007)
P<0,05 Between Control and 2ml or 4mlNo Difference betweem 2ml and 4ml
Average breeding period, cumulative and in different production sites and treatment groups (Fernandes et al.,
2007)
P<0,05 Between Control and 2ml or 4mlNo Difference betweem 2ml and 4ml
Pilot study – 20 animals(Fernandes et al., 2009, data not published)
Treatment scheme in post partum animals
Treatment group
Number of animals
Treatment description
Control 5 No treatment
Clopr1x 5 0.530mg cloprostenol as a single dose
Clopr2x 50.530mg cloprostenol divided in two doses with
a 24h interval
Clopr4x 50.530mg cloprostenol divided into 4 doses with
12h interval
Average interval calving-to-1st AI in different production sites and treatment groups (Fernandes et al.,
2007)
Conclusões
Dosage and number of administrations
Doubling of the dose does not always result in an improvement of results Saturation of existing PGF receptors Rapid metabolism (half life of 90min) Dividing of the dose into a higher number of
administrations Obtain better results with the same total dose
“O sucesso nasce do querer. Sempre que o homem aplicar a determinação e a persistência para um objetivo, ele vencerá os obstáculos, e, se não atingir o alvo, pelo menos fará coisas admiráveis”.
J os é de Al e nc ar
Carlos Antônio de Carvalho Fernandes
Med. Vet. D.Sc.