Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor...
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![Page 1: Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of.](https://reader036.fdocuments.net/reader036/viewer/2022062409/56649f515503460f94c7439a/html5/thumbnails/1.jpg)
Pain Day – The Basics of Pain
Randall Reed PhDDirector Center for Sensory Biology
Professor
Department of Molecular Biology and Genetics
Department of Neuroscience
Department of Otolaryngology – HNS
![Page 2: Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of.](https://reader036.fdocuments.net/reader036/viewer/2022062409/56649f515503460f94c7439a/html5/thumbnails/2.jpg)
Our Senses Share Many Common Properties
The IBBS Center for Sensory Biology
• Randall Reed - olfaction• Paul Fuchs - hearing• Michael Caterina - Pain/touch• Xinzhong Dong - Pain/touch• Craig Montell - vision/taste• Elisabeth Glowatzki - hearing• Jeremy Nathans - vision• King-Wai Yau - vision/olfaction• Angelika Doetzlhofer – hearing• Michael Deans - hearing
![Page 3: Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of.](https://reader036.fdocuments.net/reader036/viewer/2022062409/56649f515503460f94c7439a/html5/thumbnails/3.jpg)
Classic View of the Senses The Five Senses - Provide Information
Vision Smell Taste Hearing Touch
Also Provide Protection
![Page 4: Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of.](https://reader036.fdocuments.net/reader036/viewer/2022062409/56649f515503460f94c7439a/html5/thumbnails/4.jpg)
The Spectrum of Sensations
Pain from a Broad Perspective:
PainItchTouch
![Page 5: Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of.](https://reader036.fdocuments.net/reader036/viewer/2022062409/56649f515503460f94c7439a/html5/thumbnails/5.jpg)
TRP Channels: Molecular Gatekeepers for the Senses
TRP Channels Mediate:
•Thermal Sensation / Pain•Taste
Some aspects of:
•Vision•Olfaction•Hearing
![Page 6: Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of.](https://reader036.fdocuments.net/reader036/viewer/2022062409/56649f515503460f94c7439a/html5/thumbnails/6.jpg)
The Senses: Targets of Environmental Assault
Sensory Systems lie at interface between our inner and outer world – Subject to Damage
•Hearing Loss
•Burn/Itch
•Olfactory Loss
•Light Induced Damage
![Page 7: Pain Day – The Basics of Pain Randall Reed PhD Director Center for Sensory Biology Professor Department of Molecular Biology and Genetics Department of.](https://reader036.fdocuments.net/reader036/viewer/2022062409/56649f515503460f94c7439a/html5/thumbnails/7.jpg)
Key Opportunities/Practical Implications of Advances in Sensory Biology
Strategies to modulate (up or down) sensory perception (Pain/Auditory/Chemosensory)
Organization/Interaction of cells in tissues
Molecular and cellular genesis of specialized organelles
Understand processes of neuronal damage, repair and regeneration