P20 Heterotransplantation of the reconstructed skin model to SCID mice
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92 Ahmum JSlDjCSlD Joint Meeting P15 P18 P16 P17 THE CLINICAL HETEHOCENEITY OF LYMPHOMATOID I’AI’lILOSIS D.K.M.Chaneand K., Division of Drrmutolog; UniversiQ of Alberta, Edmonton, Alberta, CYlMdC4 l.~mphomatu~d Papulosis is a chronic cutaneous disease cbaracwrued by mvoluting and recurring papules. plaques, and nodules. Some ofthrsc ma) progrcss to form vesicular crusted lesions that heal nltb roarring. On histologic examination. lymphomatoid papulosis is chamctcrixd by P dense wdge-shaped infiltrate which contains either lnrgc at!pnd lymphocytes (type A )or small cerebrifomt atypical I? mphuc?tes (t~pr B). 10.20% ol~cases are associated with lymphoma ot’n hicb mycosis fungoides. Hodgkin’s disease, lymphocytic I! mphoma. immunoblastnc lymphoma. anaplastic large-cell lymphoma. id lethal m,dlinc !@uloma have been reponed. We repo” here five cases of I? mphomatoid papulosis each of which has had different clinical presentations. One case presented with scar-like plaques. 2 cases rhoued small scattered papules and grouped lesions. A foutth patlent had a grnerallzed papulonecrotic eruption. The final case presented m childhood and after a prolonged interval the patient de\ eloped leukemia from which he subsequently died. PlP P20 HETEROTRANSPLANTATION OF THE RECONSTRUCTED SKIN MODEL TO SCID MICE Ta NishiyPma*. TSawki’ .N Jshhii*. H Nakajima*. M Tsuncn;aa**. To Nishiyama”, *Dept. of Dcmwtalog) .Yokohama Cit! Unix wit! School of Mcdicinc, Yokohama. Japan. **Lift Scicncc Rcscarch Laboratories. Shiscido Rcswrc Ccntcr. Yokohama. Jaoan. WC made a 3.dimensional rcconstmctcd skin m&l through simultanwus culture of normel human skin tihrohlasts and kcratinwytcs. In thi\ culture system. the btmcturc was gradualI) dcstroycd and no lunger usable as an cxpcrimcntal aystcm about 3 weeks after the stat of culture. Thus wc implanted the 3. dimcnrional rcconstruacd skin mtticl into SCID mice Lo maintilin the str~cturc of the model for u longcr pxiod of time. WC compared morphological changes of the skin m&l bctwccn in vitro cultivation and trawplantation as a time COUISE study. Tltc strwturc of tbc skin m&l tmnsplantcd inta the SCID mice could hc succcssfullg tt&taincd more then 5 weeks
Transcript of P20 Heterotransplantation of the reconstructed skin model to SCID mice
92 Ahmum JSlDjCSlD Joint Meeting
P15 P18
P16
P17
THE CLINICAL HETEHOCENEITY OF LYMPHOMATOID I’AI’lILOSIS D.K.M.Chaneand K., Division of Drrmutolog; UniversiQ of Alberta, Edmonton, Alberta, CYlMdC4
l.~mphomatu~d Papulosis is a chronic cutaneous disease
cbaracwrued by mvoluting and recurring papules. plaques, and nodules.
Some ofthrsc ma) progrcss to form vesicular crusted lesions that heal
nltb roarring. On histologic examination. lymphomatoid papulosis is
chamctcrixd by P dense wdge-shaped infiltrate which contains either
lnrgc at!pnd lymphocytes (type A )or small cerebrifomt atypical
I? mphuc?tes (t~pr B). 10.20% ol~cases are associated with lymphoma
ot’n hicb mycosis fungoides. Hodgkin’s disease, lymphocytic
I! mphoma. immunoblastnc lymphoma. anaplastic large-cell lymphoma.
id lethal m,dlinc !@uloma have been reponed. We repo” here five
cases of I? mphomatoid papulosis each of which has had different
clinical presentations. One case presented with scar-like plaques. 2
cases rhoued small scattered papules and grouped lesions. A foutth
patlent had a grnerallzed papulonecrotic eruption. The final case
presented m childhood and after a prolonged interval the patient
de\ eloped leukemia from which he subsequently died.
PlP
P20
HETEROTRANSPLANTATION OF THE
RECONSTRUCTED SKIN MODEL TO SCID MICE
Ta NishiyPma*. TSawki’ .N Jshhii*. H Nakajima*. M Tsuncn;aa**.
To Nishiyama”, *Dept. of Dcmwtalog) .Yokohama Cit! Unix wit!
School of Mcdicinc, Yokohama. Japan. **Lift Scicncc Rcscarch
Laboratories. Shiscido Rcswrc Ccntcr. Yokohama. Jaoan.
WC made a 3.dimensional rcconstmctcd skin m&l
through simultanwus culture of normel human skin
tihrohlasts and kcratinwytcs. In thi\ culture system.
the btmcturc was gradualI) dcstroycd and no lunger
usable as an cxpcrimcntal aystcm about 3 weeks after the stat of culture. Thus wc implanted the 3.
dimcnrional rcconstruacd skin mtticl into SCID mice
Lo maintilin the str~cturc of the model for u longcr
pxiod of time. WC compared morphological changes of the skin m&l bctwccn in vitro cultivation and
trawplantation as a time COUISE study. Tltc strwturc
of tbc skin m&l tmnsplantcd inta the SCID mice
could hc succcssfullg tt&taincd more then 5 weeks
