P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach,...

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F1_R2 NTP Study Number: C20303 Lock Date: 05/09/2008 Cage Range: ALL Date Range: ALL Reasons For Removal: ALL Removal Date Range: ALL Treatment Groups: Include ALL Study Gender: Both TDMSE Version: 2.5.0.0_004 PWG Approval Date: NONE Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011 Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55 Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05 Species/Strain: RATS/F 344/N Lab: BNW

Transcript of P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach,...

Page 1: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

F1_R2NTP Study Number: C20303

Lock Date: 05/09/2008

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

Study Gender: Both

TDMSE Version: 2.5.0.0_004

PWG Approval Date: NONE

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

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ANIMAL ID: 1 TRT#: 1 SEX: Male DAY ON TEST: 677DOSE: Control DISP: Moribund Sacrifice HISTO: 53519

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mesenteric * Mammary Gland* Nose * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Testes * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 2 TRT#: 1 SEX: Male DAY ON TEST: 661DOSE: Control DISP: Moribund Sacrifice HISTO: 53520

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Mammary Gland * Nose * Pancreas* Parathyroid Gland Peripheral Nerve * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle Spinal Cord * Spleen* Stomach, Forestomach * Stomach, Glandular * Testes * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Adenoma* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal* Lung Alveolar Epith Hyperplasia Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Skin Trichoepithelioma

[ Trichoepithelioma TGLs = 1-14 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 3 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53521

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Nose * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 1-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 4 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53522

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Nose * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Islets, Pancreatic Hyperplasia Moderate* Kidney Nephropathy Moderate* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal* Lymph Node, Mediastinal Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 1-3 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 2-14 ]* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 4-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 5 TRT#: 1 SEX: Male DAY ON TEST: 514DOSE: Control DISP: Moribund Sacrifice HISTO: 53523

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Bronchial * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Nose * Parathyroid Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 2-14 ]

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Hyperplasia Moderate* Preputial Gland Carcinoma

[ Carcinoma TGLs = 1-15 ]* Spleen Hematopoietic Cell Proliferation Mild* Testes Atrophy Minimal

PRIMARY CAUSE OF DEATH - Preputial Gland Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 6 TRT#: 1 SEX: Male DAY ON TEST: 712DOSE: Control DISP: Moribund Sacrifice HISTO: 53524

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Nose* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Minimal

Thrombosis Mild[ Thrombosis TGLs = 3-6 ]

* Kidney Leukemia MononuclearNephropathy Minimal

* Liver Hepatocellular AdenomaBile Duct Hyperplasia Mild

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 8,9-6+18 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-21 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 10-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 6 TRT#: 1 SEX: Male DAY ON TEST: 712DOSE: Control DISP: Moribund Sacrifice HISTO: 53524

ORGAN AND ACCOUNTABLE SITE STATUS

* Skin Keratoacanthoma[ Keratoacanthoma TGLs = 1-14+15+16 ]

* Spleen Fibrosis MildLeukemia Mononuclear

[ Fibrosis TGLs = 7-21 ][ Leukemia Mononuclear TGLs = 6-21 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 4-9 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 7 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53525

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Nose* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MildInflammation Chronic, Minimal

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 3-9 ][ Atrophy TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 8 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53526

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Nose * Pancreas * Parathyroid Gland * Preputial Gland* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Minimal* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Mesenteric Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Prostate Hyperplasia Mild* Spleen Leukemia Mononuclear* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2,3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 9 TRT#: 1 SEX: Male DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53527

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Nose* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Eye Retina Atrophy Moderate

Cataract ModerateCornea Inflammation Chronic Active, Moderate

[ Inflammation TGLs = 1-13 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-6 ]* Pituitary Gland Pars Intermed Angiectasis Mild

[ Angiectasis TGLs = 4-10 ]* Spleen Leukemia Mononuclear* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 10 TRT#: 1 SEX: Male DAY ON TEST: 705DOSE: Control DISP: Moribund Sacrifice HISTO: 53528

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Nose * Parathyroid Gland* Preputial Gland * Salivary Glands * Seminal Vesicle * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLymph Node Pancreatic Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 5-16 ]* Lymph Node, Mediastinal Hyperplasia Lymphoid, Moderate* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma* Prostate Hyperplasia Mild* Skin Basal Cell Carcinoma

[ Basal Cell Carcinoma TGLs = 1-14 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 4-9 ]

PRIMARY CAUSE OF DEATH - Skin Basal Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 11 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53529

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Nose * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalBile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalMesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]* Pancreas Basophilic Focus

Hyperplasia Mild* Pituitary Gland Pars Distalis Hyperplasia Mild* Skin Squamous Cell Papilloma

[ Squamous Cell Papilloma TGLs = 2-15 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 12 TRT#: 1 SEX: Male DAY ON TEST: 686DOSE: Control DISP: Natural Death HISTO: 53530

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Nose * Parathyroid Gland * Prostate * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Seminal Vesicle

OBSERVATIONS* Adrenal Medulla Pheochromocytoma Benign

Pheochromocytoma Malignant[ Pheochromocytoma Malignant TGLs = 1-7 ]

* Heart Cardiomyopathy Moderate* Intestine Large, Cecum Inflammation Acute, Marked

Necrosis Moderate[ Inflammation TGLs = 4-16 ]

* Kidney Nephropathy Marked* Liver Fatty Change Diffuse, Mild

Bile Duct Hyperplasia Minimal* Pancreas Atrophy Marked* Pituitary Gland Pars Distalis Adenoma* Preputial Gland Hyperplasia Mild* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 3-16 ][ Atrophy TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 12 TRT#: 1 SEX: Male DAY ON TEST: 686DOSE: Control DISP: Natural Death HISTO: 53530

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Adrenal Medulla Pheochromocytoma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 15

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ANIMAL ID: 13 TRT#: 1 SEX: Male DAY ON TEST: 719DOSE: Control DISP: Moribund Sacrifice HISTO: 53531

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Nose * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Spleen * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Malignant

[ Pheochromocytoma Malignant TGLs = 4-7 ]* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal* Lymph Node, Mediastinal Ectasia Mild

[ Ectasia TGLs = 2-3 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Skin Cyst Epithelial Inclusion

[ Cyst Epithelial Inclusion TGLs = 1-14 ]* Testes Atrophy Mild* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 16

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ANIMAL ID: 14 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53532

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland* Prostate * Salivary Glands * Seminal Vesicle * Spleen* Stomach, Forestomach * Stomach, Glandular * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Minimal* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Nose Inflammation Chronic Active, Minimal* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma* Preputial Gland Adenoma

[ Adenoma TGLs = 1-14 ]* Skin Hyperplasia Squamous, Minimal

Inflammation Chronic Active, Marked[ Hyperplasia TGLs = 5-15 ][ Inflammation TGLs = 3,4-14+15 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 17

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ANIMAL ID: 15 TRT#: 1 SEX: Male DAY ON TEST: 669DOSE: Control DISP: Moribund Sacrifice HISTO: 53533

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Liver * Lymph Node, Mesenteric * Mammary Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONSBlood Vessel Aorta Mineralization Moderate

* Eye Cornea Inflammation Acute, Moderate* Heart Mineralization Moderate

[ Mineralization TGLs = 3-6 ]* Kidney Mineralization Moderate

Nephropathy Marked[ Nephropathy TGLs = 5-7 ]

* Lung Mineralization Moderate* Nose Inflammation Acute, Moderate* Pancreas Atrophy Mild* Parathyroid Gland Hyperplasia Moderate* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 4-10 ]* Stomach, Forestomach Mineralization Moderate* Stomach, Glandular Mineralization Moderate* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 6-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Kidney Nephropathy

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 18

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ANIMAL ID: 16 TRT#: 1 SEX: Male DAY ON TEST: 620DOSE: Control DISP: Moribund Sacrifice HISTO: 53534

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Testes * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland* Thymus

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-6 ]* Lung Alveolar/Bronchiolar Adenoma

Alveolar Epith Hyperplasia MildLeukemia Mononuclear

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Respirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MinimalThrombosis Mild

* Pancreas Atrophy Moderate* Pituitary Gland Pars Distalis Adenoma

Pars Distalis Angiectasis Mild[ Adenoma TGLs = 2-10 ][ Angiectasis TGLs = 1-10 ]

* Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 19

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ANIMAL ID: 16 TRT#: 1 SEX: Male DAY ON TEST: 620DOSE: Control DISP: Moribund Sacrifice HISTO: 53534

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 3,4,5-14 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 20

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ANIMAL ID: 17 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53535

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Spleen* Stomach, Forestomach * Stomach, Glandular * Testes * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Marked

[ Nephropathy TGLs = 4-7 ]* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lymph Node, Bronchial Hyperplasia Lymphoid, Mild[ Hyperplasia TGLs = 1-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-15 ]

* Nose Inflammation Chronic Active, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Skin Cyst Epithelial Inclusion

[ Cyst Epithelial Inclusion TGLs = 5-16 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 21

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ANIMAL ID: 18 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53536

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Nose * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Adenoma* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Islets, Pancreatic Carcinoma* Kidney Nephropathy Moderate* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Mild

Inflammation Chronic, Minimal* Lung Alveolar Epith Hyperplasia Minimal

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2,3-14+15 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Testes Interstit Cell AdenomaHemorrhage Mild

[ Adenoma TGLs = 1-9 ][ Hemorrhage TGLs = 5-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 22

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ANIMAL ID: 19 TRT#: 1 SEX: Male DAY ON TEST: 367DOSE: Control DISP: Moribund Sacrifice HISTO: 53537

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Liver * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Bone Osteosarcoma

[ Osteosarcoma TGLs = 5-14+20+22 ]* Heart Cardiomyopathy Minimal

Pericardium Osteosarcoma Metastatic (Bone)[ Osteosarcoma TGLs = 3-15 ]

* Kidney Nephropathy Minimal* Lung Osteosarcoma Metastatic (Bone)

[ Osteosarcoma TGLs = 4,8,10,6,7,9-4+5+17+16+18 ]* Lymph Node, Bronchial Osteosarcoma Metastatic (Bone)* Pituitary Gland Pars Distalis Hyperplasia Moderate

Skeletal Muscle Osteosarcoma Metastatic (Bone)[ Osteosarcoma TGLs = 2-21 ]

* Testes Interstit Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Bone Osteosarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 23

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ANIMAL ID: 20 TRT#: 1 SEX: Male DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53538

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Nose* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lung Alveolar/Bronchiolar Adenoma[ Alveolar/Bronchiolar Adenoma TGLs = 4-15 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 1-15 ]

* Pituitary Gland Pars Intermed Hyperplasia Mild* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 24

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ANIMAL ID: 21 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53539

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Mammary Gland * Nose * Pancreas * Parathyroid Gland* Pituitary Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Minimal* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 25

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ANIMAL ID: 22 TRT#: 1 SEX: Male DAY ON TEST: 679DOSE: Control DISP: Natural Death HISTO: 53540

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Harderian Gland* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Spleen * Stomach, Forestomach * Stomach, Glandular* Testes * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Eye * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Nose* Seminal Vesicle

OBSERVATIONS* Heart Cardiomyopathy Moderate* Kidney Nephropathy Marked

[ Nephropathy TGLs = 5-7+14 ]* Liver Basophilic Focus

Inflammation Chronic, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 1-15 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 26

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ANIMAL ID: 23 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53541

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Nose * Parathyroid Gland* Preputial Gland * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalNecrosis Moderate

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Prostate Hyperplasia Minimal* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-14 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 5-9 ]* Thyroid Gland C Cell Adenoma

[ Adenoma TGLs = 1-3 ]Tooth Dysplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 27

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ANIMAL ID: 24 TRT#: 1 SEX: Male DAY ON TEST: 676DOSE: Control DISP: Moribund Sacrifice HISTO: 53542

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Lymph Node, Mesenteric* Mammary Gland * Nose * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Medulla Hyperplasia Moderate* Heart Cardiomyopathy Mild* Islets, Pancreatic Adenoma* Kidney Nephropathy Mild* Liver Bile Duct Hyperplasia Minimal* Lung Mediastinum Inflammation Granulomatous, Moderate

[ Inflammation TGLs = 1-4+5 ]Mesentery Inflammation Chronic Active, Mild

[ Inflammation TGLs = 2-14 ]* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Stomach, Forestomach Ulcer Moderate* Testes Interstit Cell Hyperplasia Minimal* Thyroid Gland Follicular Cel Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 28

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ANIMAL ID: 25 TRT#: 1 SEX: Male DAY ON TEST: 675DOSE: Control DISP: Moribund Sacrifice HISTO: 53543

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone Marrow * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Liver * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland Peripheral Nerve* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle

Spinal Cord * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Bone Osteoma

[ Osteoma TGLs = 4-17 ]* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Lung Foreign Body

Inflammation Chronic Active, Marked[ Inflammation TGLs = 1,2-5+4 ]

* Nose Foreign BodyInflammation Acute, Minimal

* Pancreas Hyperplasia Moderate* Pituitary Gland Pars Distalis Hyperplasia Moderate* Skin Keratoacanthoma

[ Keratoacanthoma TGLs = 3-14+15 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 5-9 ]

PRIMARY CAUSE OF DEATH - Lung Inflammation

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 29

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ANIMAL ID: 26 TRT#: 1 SEX: Male DAY ON TEST: 492DOSE: Control DISP: Moribund Sacrifice HISTO: 53544

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Nose* Parathyroid Gland * Pituitary Gland * Prostate * Salivary Glands* Seminal Vesicle * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus* Pancreas Atrophy Minimal* Preputial Gland Carcinoma

[ Carcinoma TGLs = 2-14+15 ]* Skin Inflammation Chronic Active, Marked

[ Inflammation TGLs = 1-14+15 ]* Spleen Hematopoietic Cell Proliferation Mild* Testes Interstit Cell Hyperplasia Mild* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Preputial Gland Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 30

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ANIMAL ID: 27 TRT#: 1 SEX: Male DAY ON TEST: 551DOSE: Control DISP: Moribund Sacrifice HISTO: 53545

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mandibular* Nose * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-1 ]* Heart Leukemia Mononuclear* Intestine Large, Cecum Leukemia Mononuclear* Intestine Small, Duodenum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Lymph Node, Mesenteric Leukemia Mononuclear* Pancreas Atrophy Mild

Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 31

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ANIMAL ID: 27 TRT#: 1 SEX: Male DAY ON TEST: 551DOSE: Control DISP: Moribund Sacrifice HISTO: 53545

ORGAN AND ACCOUNTABLE SITE STATUS

* Stomach, Forestomach Ulcer Marked[ Ulcer TGLs = 7-15 ]

* Testes Interstit Cell Adenoma[ Adenoma TGLs = 5-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 32

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ANIMAL ID: 28 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53546

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Nose * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Moderate* Islets, Pancreatic Carcinoma* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2,3-15+14 ]

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1,5-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 33

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ANIMAL ID: 29 TRT#: 1 SEX: Male DAY ON TEST: 635DOSE: Control DISP: Moribund Sacrifice HISTO: 53547

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Nose* Pancreas * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Glandular* Testes * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Inflammation Chronic Active, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Prostate Inflammation Suppurative, Mild* Stomach, Forestomach Ulcer Moderate

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 34

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ANIMAL ID: 30 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53548

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Nose * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Kidney Nephropathy Moderate* Liver Degeneration Cystic, Mild

Bile Duct Hyperplasia MinimalLeukemia Mononuclear

* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-3 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-23 ]

* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 5-10 ]

* Skin Cyst Epithelial InclusionSquamous Cell Papilloma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 35

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ANIMAL ID: 30 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53548

ORGAN AND ACCOUNTABLE SITE STATUS

[ Cyst Epithelial Inclusion TGLs = 2-22 ][ Squamous Cell Papilloma TGLs = 1-24 ]

* Spleen Leukemia Mononuclear* Testes Atrophy Moderate* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 36

Page 37: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 31 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53549

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Mammary Gland * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, MarkedBile Duct Hyperplasia Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-14 ]

* Lung Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-15 ]

* Nose Respirat Epith Hyperplasia MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Minimal* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Prostate Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 37

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ANIMAL ID: 31 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53549

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]* Thyroid Gland Follicular Cel Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 38

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ANIMAL ID: 32 TRT#: 1 SEX: Male DAY ON TEST: 591DOSE: Control DISP: Moribund Sacrifice HISTO: 53550

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Jejunum * Islets, Pancreatic* Mammary Gland * Nose * Parathyroid Gland * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Nephropathy Mild* Larynx Inflammation Chronic Active, Mild* Liver Bile Duct Hyperplasia Mild

Leukemia Mononuclear* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-4+5 ]Lymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-14 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Pancreas Atrophy Moderate

Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-14 ]* Testes Bilateral, Interstit Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 39

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ANIMAL ID: 32 TRT#: 1 SEX: Male DAY ON TEST: 591DOSE: Control DISP: Moribund Sacrifice HISTO: 53550

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 2-9 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 40

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ANIMAL ID: 33 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53551

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Nose * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Testes * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Moderate

Skeletal Muscle Lipoma[ Lipoma TGLs = 1-14+15 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-6 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 41

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ANIMAL ID: 33 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53551

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 42

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ANIMAL ID: 34 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53552

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Medulla Hyperplasia Moderate* Bone Marrow Hyperplasia Reticulum Cell, Marked* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, Minimal

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Skin Cyst Epithelial Inclusion Moderate

[ Cyst Epithelial Inclusion TGLs = 1-7 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2,4-9 ]* Thyroid Gland C Cell Adenoma

C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 43

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ANIMAL ID: 35 TRT#: 1 SEX: Male DAY ON TEST: 564DOSE: Control DISP: Moribund Sacrifice HISTO: 53553

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

INSUFFICIENT TISSUE* Thymus

OBSERVATIONS* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Hepatodiaphragmatic Nodule

Bile Duct Hyperplasia MildInflammation Chronic, MinimalLeukemia Mononuclear

[ Hepatodiaphragmatic Nodule TGLs = 4-6 ][ Leukemia Mononuclear TGLs = 3-6 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-4+5 ]

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-16 ]

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 44

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ANIMAL ID: 35 TRT#: 1 SEX: Male DAY ON TEST: 564DOSE: Control DISP: Moribund Sacrifice HISTO: 53553

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mesenteric Leukemia MononuclearMesentery Inflammation Chronic Active, Mild

[ Inflammation TGLs = 8-17 ]* Nose Respirat Epith Hyperplasia Minimal

Inflammation Chronic Active, Minimal* Pituitary Gland Pars Distalis Adenoma* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-15 ]* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 7-9 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 45

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ANIMAL ID: 36 TRT#: 1 SEX: Male DAY ON TEST: 698DOSE: Control DISP: Moribund Sacrifice HISTO: 53554

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Pancreas * Parathyroid Gland * Preputial Gland* Salivary Glands * Seminal Vesicle * Skin * Stomach, Glandular* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

INSUFFICIENT TISSUE* Intestine Large, Rectum

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild

Thrombosis Minimal* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Bile Duct Hyperplasia Mild

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-6 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-4+5 ]

Lymph Node Pancreatic Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Thrombosis Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 36 TRT#: 1 SEX: Male DAY ON TEST: 698DOSE: Control DISP: Moribund Sacrifice HISTO: 53554

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Inflammation Suppurative, Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-14 ]* Stomach, Forestomach Ulcer Moderate

[ Ulcer TGLs = 7,9-10+15 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 6-9 ]* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 37 TRT#: 1 SEX: Male DAY ON TEST: 614DOSE: Control DISP: Natural Death HISTO: 53555

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Harderian Gland* Islets, Pancreatic * Larynx * Lymph Node, Bronchial * Lymph Node, Mesenteric* Nose * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Testes * Thymus * Thyroid Gland* Trachea

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Adrenal Cortex * Adrenal Medulla * Bone Marrow * Eye* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Stomach, Glandular * Urinary Bladder

OBSERVATIONS* Brain Hemorrhage Mild* Heart Cardiomyopathy Moderate* Kidney Nephropathy Minimal* Liver Basophilic Focus

Eosinophilic FocusBile Duct Hyperplasia Mild

* Lung Alveolar/Bronchiolar AdenomaMesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-14 ]* Pancreas Atrophy Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 38 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53556

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Nose * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Adenoma* Adrenal Medulla Hyperplasia Moderate* Heart Cardiomyopathy Mild

[ Cardiomyopathy TGLs = 1-6 ]* Kidney Nephropathy Moderate* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Minimal

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Testes Interstit Cell AdenomaAtrophy Marked

[ Adenoma TGLs = 2-14 ][ Atrophy TGLs = 3-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 39 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53557

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lymph Node, Mesenteric Hyperplasia Lymphoid, Mild* Nose Olfactory Epi Metaplasia Respiratory, Minimal* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Spleen Hyperplasia Stromal, Moderate

[ Hyperplasia TGLs = 2-6 ]* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]

Animal Note: TGL 3 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 50

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ANIMAL ID: 40 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53558

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Parathyroid Gland* Preputial Gland * Salivary Glands * Seminal Vesicle * Stomach, Forestomach* Stomach, Glandular * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Eye Retina Atrophy Marked

Cataract Marked[ Cataract TGLs = 1-13 ]

* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MildInflammation Chronic, MinimalLeukemia MononuclearMixed Cell Focus

[ Clear Cell Focus TGLs = 6-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-7 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 40 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53558

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Foreign BodyRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, Mild* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Angiectasis Mild

Leukemia Mononuclear[ Angiectasis TGLs = 7-10 ]

* Prostate Hyperplasia Mild* Skin Squamous Cell Papilloma

[ Squamous Cell Papilloma TGLs = 2-14 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Testes Interstit Cell Adenoma

Atrophy Moderate[ Adenoma TGLs = 4-9 ]

* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 52

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ANIMAL ID: 41 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53559

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose * Pancreas* Parathyroid Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Pheochromocytoma Benign* Eye Cataract Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14+15+16 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4,5-7+6 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Preputial Gland Adenoma* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 53

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ANIMAL ID: 42 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53560

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Nose * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Skin Keratoacanthoma

[ Keratoacanthoma TGLs = 2-22 ]* Testes Atrophy Marked

[ Atrophy TGLs = 1-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 54

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ANIMAL ID: 43 TRT#: 1 SEX: Male DAY ON TEST: 645DOSE: Control DISP: Moribund Sacrifice HISTO: 53561

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Nose Inflammation Chronic Active, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Prostate Inflammation Suppurative, Mild* Testes Interstit Cell Hyperplasia Minimal* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 55

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ANIMAL ID: 44 TRT#: 1 SEX: Male DAY ON TEST: 654DOSE: Control DISP: Natural Death HISTO: 53562

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Nose * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia MononuclearPheochromocytoma Benign

* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Mesenchymal Tumor MalignantNephropathy Mild

[ Mesenchymal Tumor Malignant TGLs = 4-15+16+17 ]* Liver Bile Duct Hyperplasia Mild

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-6 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 8-20 ]* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 6-19 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 56

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ANIMAL ID: 44 TRT#: 1 SEX: Male DAY ON TEST: 654DOSE: Control DISP: Natural Death HISTO: 53562

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-14 ]* Testes Interstit Cell Adenoma

PRIMARY CAUSE OF DEATH - Kidney Mesenchymal Tumor Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 57

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ANIMAL ID: 45 TRT#: 1 SEX: Male DAY ON TEST: 730DOSE: Control DISP: Terminal Sacrifice HISTO: 53563

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal* Nose Respirat Epith Hyperplasia Mild

Inflammation Chronic Active, Minimal* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Hyperplasia Mild

[ Hyperplasia TGLs = 1-10 ]* Testes Interstit Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 58

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ANIMAL ID: 46 TRT#: 1 SEX: Male DAY ON TEST: 717DOSE: Control DISP: Moribund Sacrifice HISTO: 53564

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Mammary Gland * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Testes * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Heart Leukemia Mononuclear* Islets, Pancreatic Adenoma* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Eosinophilic Focus

Bile Duct Hyperplasia MildLeukemia Mononuclear

[ Eosinophilic Focus TGLs = 9,11,10,12-6+16+15 ][ Leukemia Mononuclear TGLs = 6-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 8-8 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 7-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 59

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ANIMAL ID: 46 TRT#: 1 SEX: Male DAY ON TEST: 717DOSE: Control DISP: Moribund Sacrifice HISTO: 53564

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Leukemia MononuclearThrombosis Mild

* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 2-10 ]

* Spleen Fibrosis MildLeukemia Mononuclear

[ Fibrosis TGLs = 4,5-15+16 ][ Leukemia Mononuclear TGLs = 3-14 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 1-3 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia MononuclearAnimal Note: TGL 13 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 60

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ANIMAL ID: 47 TRT#: 1 SEX: Male DAY ON TEST: 670DOSE: Control DISP: Moribund Sacrifice HISTO: 53565

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Testes * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Degeneration Cystic, Mild

Bile Duct Hyperplasia MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-15 ]* Nose Inflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Minimal* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 1-10 ]

* Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 47 TRT#: 1 SEX: Male DAY ON TEST: 670DOSE: Control DISP: Moribund Sacrifice HISTO: 53565

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 2-14 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 48 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53566

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Nose * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Moderate[ Nephropathy TGLs = 3-7 ]

* Liver Basophilic FocusClear Cell FocusEosinophilic Focus

Bile Duct Hyperplasia MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Spleen Fibrosis Moderate

Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 48 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53566

ORGAN AND ACCOUNTABLE SITE STATUS

[ Fibrosis TGLs = 1-6 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 49 TRT#: 1 SEX: Male DAY ON TEST: 729DOSE: Control DISP: Terminal Sacrifice HISTO: 53567

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Nose * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Benign* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lung Inflammation Chronic Active, Minimal[ Inflammation TGLs = 3-5 ]

* Pituitary Gland Pars Distalis Hyperplasia Mild* Skin Basal Cell Adenoma* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 50 TRT#: 1 SEX: Male DAY ON TEST: 562DOSE: Control DISP: Moribund Sacrifice HISTO: 53568

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland* Preputial Gland * Salivary Glands * Skin * Stomach, Glandular* Thymus * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Mesothelioma Malignant* Adrenal Medulla Hyperplasia Moderate* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild

Thrombosis Marked* Intestine Small, Ileum Mesothelioma Malignant* Intestine Small, Jejunum Mesothelioma Malignant* Kidney Mesothelioma Malignant

Nephropathy Mild* Liver Necrosis Mild

[ Necrosis TGLs = 6-6 ]* Lung Thrombosis Mild

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2-15 ]

* Nose Thrombosis Moderate* Pancreas Mesothelioma Malignant* Pituitary Gland Pars Distalis Adenoma* Prostate Inflammation Suppurative, Mild

Mesothelioma Malignant* Seminal Vesicle Mesothelioma Malignant

Skeletal Muscle Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 50 TRT#: 1 SEX: Male DAY ON TEST: 562DOSE: Control DISP: Moribund Sacrifice HISTO: 53568

ORGAN AND ACCOUNTABLE SITE STATUS

[ Mesothelioma Malignant TGLs = 7,8-16+17 ]* Spleen Hematopoietic Cell Proliferation Moderate

Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Testes Interstit Cell Adenoma

Atrophy ModerateMesothelioma Malignant

[ Adenoma TGLs = 4-9 ][ Atrophy TGLs = 3-9 ][ Mesothelioma Malignant TGLs = 5-18 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Testes Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 201 TRT#: 3 SEX: Male DAY ON TEST: 631DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53819

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mesenteric * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland* Thymus

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Stomach, Forestomach Inflammation Chronic Active, Moderate* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 202 TRT#: 3 SEX: Male DAY ON TEST: 619DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53820

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Parathyroid Gland * Pituitary Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear

Necrosis Mild* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Fatty Change Diffuse, Mild

Bile Duct Hyperplasia MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear

Lymph Node Renal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-15 ]

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-16 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Leukemia Mononuclear* Prostate Inflammation Suppurative, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 202 TRT#: 3 SEX: Male DAY ON TEST: 619DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53820

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-14 ]

* Stomach, Forestomach Hyperplasia Squamous, MinimalUlcer Marked

[ Hyperplasia TGLs = 6-10 ][ Ulcer TGLs = 6-16 ]

* Testes Interstit Cell Adenoma[ Adenoma TGLs = 1-9 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 203 TRT#: 3 SEX: Male DAY ON TEST: 611DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53821

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Leukemia Mononuclear

Lymph Node Renal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-16 ]

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 7-8 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 203 TRT#: 3 SEX: Male DAY ON TEST: 611DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53821

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2,3-14 ]

* Testes Hemorrhage Minimal[ Hemorrhage TGLs = 4-9 ]

* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 204 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53822

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Bronchial* Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Benign* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Mild* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Marked* Pancreas Atrophy Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 205 TRT#: 3 SEX: Male DAY ON TEST: 630DOSE: 25 ppm DISP: Natural Death HISTO: 53823

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Islets, Pancreatic* Larynx * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Thyroid Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Heart Cardiomyopathy Mild

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-7 ]* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 205 TRT#: 3 SEX: Male DAY ON TEST: 630DOSE: 25 ppm DISP: Natural Death HISTO: 53823

ORGAN AND ACCOUNTABLE SITE STATUS

Leukemia MononuclearOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 6-10 ]* Prostate Inflammation Suppurative, Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3,4-14 ]* Testes Atrophy Marked* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 206 TRT#: 3 SEX: Male DAY ON TEST: 543DOSE: 25 ppm DISP: Natural Death HISTO: 53824

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Brain* Esophagus * Eye * Harderian Gland * Islets, Pancreatic* Kidney * Lung * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Thymus * Thyroid Gland

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Bone Marrow * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Pituitary Gland * Trachea

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Thrombosis Mild* Liver Inflammation Chronic, Minimal

Necrosis Moderate[ Necrosis TGLs = 6-6 ]

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 3-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Minimal

Thrombosis Marked* Prostate Mesothelioma Malignant* Spleen Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 206 TRT#: 3 SEX: Male DAY ON TEST: 543DOSE: 25 ppm DISP: Natural Death HISTO: 53824

ORGAN AND ACCOUNTABLE SITE STATUS

* Testes Bilateral, Interstit Cell AdenomaMesothelioma Malignant

[ Adenoma TGLs = 4,5-9 ][ Mesothelioma Malignant TGLs = 2-15 ]

* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 207 TRT#: 3 SEX: Male DAY ON TEST: 355DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53825

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Parathyroid Gland * Preputial Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Kidney Hydronephrosis Moderate

Inflammation Suppurative, MildNephropathy Moderate

[ Hydronephrosis TGLs = 3-7 ]* Liver Carcinoma Metastatic (Urinary Bladder)

[ Carcinoma TGLs = 4-14 ]* Lung Carcinoma Metastatic (Urinary Bladder)

Mesentery Carcinoma Metastatic (Urinary Bladder)[ Carcinoma TGLs = 2-17 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy ModerateCarcinoma Metastatic (Urinary Bladder)

[ Carcinoma TGLs = 7-6 ]* Pituitary Gland Pars Distalis Hyperplasia Mild* Prostate Carcinoma Metastatic (Urinary Bladder)* Seminal Vesicle Carcinoma Metastatic (Urinary Bladder)

Skeletal Muscle Carcinoma Metastatic (Urinary Bladder)

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 207 TRT#: 3 SEX: Male DAY ON TEST: 355DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53825

ORGAN AND ACCOUNTABLE SITE STATUS

[ Carcinoma TGLs = 6-18 ]* Testes Interstit Cell Hyperplasia Minimal

Hyperplasia Mesothelium, Minimal* Urinary Bladder Transit Epithe Carcinoma

[ Carcinoma TGLs = 5-10+15+16 ]

PRIMARY CAUSE OF DEATH - Urinary Bladder Transit Epithe Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 208 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53826

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Pancreas * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Islets, Pancreatic Carcinoma

Hyperplasia Marked[ Carcinoma TGLs = 4-14 ]

* Kidney Nephropathy Mild* Liver Clear Cell Focus

Inflammation Chronic, Minimal* Lung Alveolar Epith Hyperplasia Minimal

[ Hyperplasia TGLs = 1-4 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3,5-9 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 209 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53827

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Pituitary Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Moderate* Liver Fatty Change Diffuse, Moderate

Inflammation Chronic, Minimal* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Mild* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 210 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53828

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Marked* Liver Clear Cell Focus

Fatty Change Diffuse, MildBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 2-14 ]

* Lung Alveolar/Bronchiolar Carcinoma* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-15 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 211 TRT#: 3 SEX: Male DAY ON TEST: 619DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53829

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Testes * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Moderate* Liver Basophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Minimal[ Hyperplasia TGLs = 2-4 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 1-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 212 TRT#: 3 SEX: Male DAY ON TEST: 668DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53830

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Brain Histiocytic Sarcoma

[ Histiocytic Sarcoma TGLs = 5-1 ]* Heart Histiocytic Sarcoma* Kidney Histiocytic Sarcoma

Nephropathy Mild[ Histiocytic Sarcoma TGLs = 6-7 ]

* Liver Histiocytic Sarcoma[ Histiocytic Sarcoma TGLs = 4-6 ]

* Lung Histiocytic Sarcoma[ Histiocytic Sarcoma TGLs = 2-4+5 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

Thrombosis Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild

[ Hyperplasia TGLs = 7-10 ]* Spleen Hematopoietic Cell Proliferation Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 212 TRT#: 3 SEX: Male DAY ON TEST: 668DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53830

ORGAN AND ACCOUNTABLE SITE STATUS

[ Hematopoietic Cell Proliferation TGLs = 3-14 ]* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 1-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Brain Histiocytic Sarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 213 TRT#: 3 SEX: Male DAY ON TEST: 548DOSE: 25 ppm DISP: Natural Death HISTO: 53831

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Heart * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland * Thymus

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum

OBSERVATIONS* Epididymis Granuloma Sperm Moderate

[ Granuloma Sperm TGLs = 4-9 ]* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Minimal[ Basophilic Focus TGLs = 5-6 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 1-10 ]

* Testes Atrophy MarkedMesothelioma Malignant

[ Atrophy TGLs = 2-9 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 214 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53832

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Bilateral Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Moderate* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Clear Cell Focus

Eosinophilic FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Pancreas Atrophy Marked* Parathyroid Gland Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 214 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53832

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 1-14 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-16 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 215 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53833

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate* Eye Degeneration Marked

[ Degeneration TGLs = 4-13 ]* Heart Cardiomyopathy Moderate* Kidney Nephropathy Marked

[ Nephropathy TGLs = 3-7 ]* Liver Angiectasis Mild

Fatty Change Diffuse, MildBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Skin Subcut Tiss Fibroma

Hyperkeratosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 215 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53833

ORGAN AND ACCOUNTABLE SITE STATUS

[ Fibroma TGLs = 1-15 ][ Hyperkeratosis TGLs = 2-16 ]

* Testes Atrophy ModerateArteriole Inflammation Moderate

Mesothelioma MalignantTongue Squamous Cell Papilloma

[ Squamous Cell Papilloma TGLs = 6-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 216 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53834

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Pancreas* Parathyroid Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

INSUFFICIENT TISSUE* Preputial Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate

Pheochromocytoma Benign* Heart Cardiomyopathy Moderate* Kidney Leukemia Mononuclear

Nephropathy Marked[ Nephropathy TGLs = 5-7 ]

* Liver Clear Cell FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Clear Cell Focus TGLs = 4-6 ]* Lung Alveolar Epith Hyperplasia Minimal

[ Hyperplasia TGLs = 1-5 ]* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 91

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ANIMAL ID: 216 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53834

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Hyperplasia Moderate* Spleen Leukemia Mononuclear* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 3-9 ][ Atrophy TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 217 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53835

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Parathyroid Gland * Preputial Gland * Salivary Glands * Skin* Thymus * Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia MononuclearNecrosis Minimal

[ Clear Cell Focus TGLs = 7-6 ][ Leukemia Mononuclear TGLs = 5-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 4-16 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy MildMesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 217 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53835

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 6-10 ]

* Prostate Mesothelioma Malignant* Seminal Vesicle Mesothelioma Malignant

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2-14 ]

* Spleen Leukemia Mononuclear* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 8-17 ][ Mesothelioma Malignant TGLs = 3-15 ]

* Urinary Bladder Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 218 TRT#: 3 SEX: Male DAY ON TEST: 711DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53836

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Glandular * Thymus* Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Pericardium Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 4-21 ]

* Kidney Renal Tubule Hyperplasia MildNephropathy Mild

* Liver Degeneration Cystic, MildHepatocellular Adenoma

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

[ Hepatocellular Adenoma TGLs = 5-18 ][ Inflammation TGLs = 6-6+18 ]

* Lung Alveolar Epith Hyperplasia MinimalMesothelioma Malignant

[ Mesothelioma Malignant TGLs = 11,12-5+4+17 ]* Mammary Gland Hyperplasia Mild

[ Hyperplasia TGLs = 1-14+15 ]Mesentery Fat Necrosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 218 TRT#: 3 SEX: Male DAY ON TEST: 711DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53836

ORGAN AND ACCOUNTABLE SITE STATUS

[ Necrosis TGLs = 8-19 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 9-10 ]

Pleura Mesothelioma MalignantSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 3-20 ]* Spleen Mesothelioma Malignant* Stomach, Forestomach Ulcer Mild* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 7-9 ]

* Urinary Bladder Transit Epithe Carcinoma[ Carcinoma TGLs = 13-10 ]

PRIMARY CAUSE OF DEATH - Pleura Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 219 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53837

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Lymph Node, Bronchial * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Islets, Pancreatic Adenoma* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, Mild

Bile Duct Hyperplasia MinimalInflammation Chronic, Mild

* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Mild

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Hyperplasia Moderate* Skin Squamous Cell Papilloma

[ Squamous Cell Papilloma TGLs = 2-14 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 220 TRT#: 3 SEX: Male DAY ON TEST: 599DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53838

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Mild

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-7 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Prostate Inflammation Suppurative, Mild* Stomach, Forestomach Inflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 98

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ANIMAL ID: 220 TRT#: 3 SEX: Male DAY ON TEST: 599DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53838

ORGAN AND ACCOUNTABLE SITE STATUS

* Testes Mesothelioma Malignant* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 99

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ANIMAL ID: 221 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53839

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Pancreas* Parathyroid Gland * Prostate * Salivary Glands * Seminal Vesicle* Stomach, Forestomach * Stomach, Glandular * Testes * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia MononuclearPheochromocytoma Benign

* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Basophilic Focus

Degeneration Cystic, MarkedEosinophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia Mononuclear

[ Degeneration TGLs = 3-15 ]* Lung Alveolar Epith Hyperplasia Mild

Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 100

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ANIMAL ID: 221 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53839

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 5-10 ]

* Preputial Gland Hyperplasia Mild* Skin Cyst Epithelial Inclusion

[ Cyst Epithelial Inclusion TGLs = 1-16 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 101

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ANIMAL ID: 222 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53840

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Pituitary Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Mild* Islets, Pancreatic Adenoma* Kidney Nephropathy Mild* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 1-6 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 2,3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 102

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ANIMAL ID: 223 TRT#: 3 SEX: Male DAY ON TEST: 563DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53841

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Jejunum * Islets, Pancreatic * Pancreas* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Larynx Carcinoma Metastatic (Thyroid Gland)* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Carcinoma Metastatic (Thyroid Gland)

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-15 ]

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 8-18 ]

* Lymph Node, Bronchial Carcinoma Metastatic (Thyroid Gland)

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 103

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ANIMAL ID: 223 TRT#: 3 SEX: Male DAY ON TEST: 563DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53841

ORGAN AND ACCOUNTABLE SITE STATUS

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-14 ]

* Lymph Node, Mesenteric Leukemia MononuclearMesentery Fat Necrosis Mild

[ Necrosis TGLs = 6-17 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Moderate

Thrombosis Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Prostate Inflammation Suppurative, Minimal* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-16 ]* Testes Mesothelioma Malignant* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 1-3 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 104

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ANIMAL ID: 224 TRT#: 3 SEX: Male DAY ON TEST: 656DOSE: 25 ppm DISP: Natural Death HISTO: 53842

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Islets, Pancreatic * Larynx * Mammary Gland * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Skin* Stomach, Forestomach * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

AUTO PRECLUDES DIAG.* Intestine Large, Colon * Intestine Small, Jejunum

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Adrenal Medulla Pheochromocytoma Benign* Bone Marrow Histiocytic Sarcoma* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild

Thrombosis Moderate* Intestine Large, Cecum Inflammation Acute, Moderate* Kidney Renal Tubule Carcinoma

Nephropathy Mild* Liver Fatty Change Diffuse, Marked

Necrosis Moderate[ Necrosis TGLs = 3-6 ]

* Lung Histiocytic Sarcoma* Lymph Node, Bronchial Histiocytic Sarcoma

[ Histiocytic Sarcoma TGLs = 1-3 ]* Lymph Node, Mesenteric Histiocytic Sarcoma* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 224 TRT#: 3 SEX: Male DAY ON TEST: 656DOSE: 25 ppm DISP: Natural Death HISTO: 53842

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Hyperplasia Mild

Mesothelioma Malignant* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Seminal Vesicle Mesothelioma Malignant* Spleen Histiocytic Sarcoma

Mesothelioma Malignant[ Histiocytic Sarcoma TGLs = 2-14 ]

* Stomach, Glandular Mesothelioma Malignant* Testes Atrophy Moderate

Interstit Cell Hyperplasia Minimal* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Spleen Histiocytic Sarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 225 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53843

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Mammary Gland * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Benign* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Clear Cell Focus

Fatty Change Diffuse, MildInflammation Chronic, MinimalLeukemia Mononuclear

[ Clear Cell Focus TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Mild* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-14 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 225 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53843

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Hyperplasia Moderate* Skin Cyst Epithelial Inclusion

[ Cyst Epithelial Inclusion TGLs = 1-7 ]* Spleen Leukemia Mononuclear* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 5-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 226 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53844

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Preputial Gland * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Adenoma* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Inflammation Chronic, Minimal* Lung Alveolar Epith Hyperplasia Minimal

Squamous Cell Carcinoma[ Squamous Cell Carcinoma TGLs = 3-5 ]

* Nose Turbinate Atrophy MildForeign Body

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Hyperplasia Moderate* Prostate Hyperplasia Mild* Salivary Glands Atrophy Mild* Testes Bilateral, Interstit Cell Adenoma

Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 226 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53844

ORGAN AND ACCOUNTABLE SITE STATUS

Mesothelioma Malignant[ Adenoma TGLs = 1,4-9 ][ Atrophy TGLs = 2-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 227 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53845

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Lymph Node, Mediastinal * Parathyroid Gland * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Moderate* Larynx Inflammation Chronic Active, Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-19 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 227 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53845

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy MildHyperplasia Minimal

* Skin Subcut Tiss Fibroma[ Fibroma TGLs = 1-14+15 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-17 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 4-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 228 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53846

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Hyperplasia Mesothelium, Minimal* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Fatty Change Diffuse, MildInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Testes Bilateral, Interstit Cell Adenoma

Tunic Hyperplasia Minimal[ Adenoma TGLs = 2,4-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 228 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53846

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 114

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ANIMAL ID: 229 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53847

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Intestine Small, Jejunum Sarcoma Stromal

[ Sarcoma Stromal TGLs = 5-14 ]* Kidney Nephropathy Mild* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Moderate[ Hyperplasia TGLs = 6,7-5+14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-7 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 115

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ANIMAL ID: 229 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53847

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 2-10 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 4,8-9 ]* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 1-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 116

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ANIMAL ID: 230 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53848

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Moderate* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 2-6 ]

* Lung Alveolar Epith Hyperplasia Moderate[ Hyperplasia TGLs = 1-4 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Hyperplasia Mild* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 117

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ANIMAL ID: 231 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53849

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Moderate* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, MildInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 2,3-7+6 ]* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Mild

Foreign BodyTurbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy Moderate* Pituitary Gland Pars Distalis Adenoma* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 1-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 118

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ANIMAL ID: 231 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53849

ORGAN AND ACCOUNTABLE SITE STATUS

* Testes Interstit Cell Hyperplasia Mild* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 4-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 232 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53850

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Clear Cell Focus

Hepatodiaphragmatic NoduleInflammation Chronic, MinimalLeukemia Mononuclear

[ Hepatodiaphragmatic Nodule TGLs = 2-6 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Prostate Hyperplasia Moderate* Spleen Leukemia Mononuclear* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 1-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 120

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ANIMAL ID: 232 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53850

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 233 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53851

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia Mild* Adrenal Medulla Bilateral Pheochromocytoma Benign* Heart Cardiomyopathy Moderate* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Degeneration Cystic, Moderate

Eosinophilic FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mandibular Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-16 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 233 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53851

ORGAN AND ACCOUNTABLE SITE STATUS

Respirat Epith Hyperplasia MildInflammation Chronic Active, Marked

Olfactory Epi Metaplasia Respiratory, Marked* Pancreas Hyperplasia Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-14 ]* Testes Interstit Cell Adenoma

Atrophy Moderate[ Adenoma TGLs = 3-9 ][ Atrophy TGLs = 4-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 234 TRT#: 3 SEX: Male DAY ON TEST: 466DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53852

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Medulla Pheochromocytoma Benign* Heart Inflammation Chronic Active, Moderate* Kidney Inflammation Suppurative, Mild

Nephropathy ModerateThrombosis Moderate

* Liver Fatty Change Diffuse, MinimalInflammation Chronic, MildNecrosis Moderate

[ Necrosis TGLs = 4-6 ]* Lung Inflammation Acute, Marked

Thrombosis Moderate[ Inflammation TGLs = 2-4+5 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-7 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Minimal

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 234 TRT#: 3 SEX: Male DAY ON TEST: 466DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53852

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Necrosis Mild[ Necrosis TGLs = 5-6 ]

* Testes Interstit Cell Hyperplasia Mild* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Heart Inflammation

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 235 TRT#: 3 SEX: Male DAY ON TEST: 535DOSE: 25 ppm DISP: Natural Death HISTO: 53853

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Harderian Gland * Intestine Large, Colon * Intestine Large, Rectum* Islets, Pancreatic * Kidney * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Pituitary Gland* Preputial Gland * Salivary Glands * Skin * Thymus* Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

AUTO PRECLUDES DIAG.* Eye * Intestine Large, Cecum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum

OBSERVATIONS* Adrenal Cortex Adenoma* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Liver Inflammation Chronic, Minimal

Necrosis Moderate[ Necrosis TGLs = 7-6 ]

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 3-14 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

Thrombosis Marked* Pancreas Mesothelioma Malignant

Peritoneum Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2,4,8-17+15+16 ]

* Prostate Inflammation Suppurative, MildMesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 235 TRT#: 3 SEX: Male DAY ON TEST: 535DOSE: 25 ppm DISP: Natural Death HISTO: 53853

ORGAN AND ACCOUNTABLE SITE STATUS

* Seminal Vesicle Mesothelioma Malignant* Spleen Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 5,6-9 ]

* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Peritoneum Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 236 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53854

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Benign* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Islets, Pancreatic Hyperplasia Moderate* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, Minimal

Bile Duct Hyperplasia MinimalInflammation Chronic, Mild

[ Basophilic Focus TGLs = 6-6 ][ Clear Cell Focus TGLs = 6-6 ]

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 5-16 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 236 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53854

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Adenoma

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2-14 ]

* Testes Interstit Cell AdenomaMesothelioma Malignant

[ Adenoma TGLs = 4-9 ][ Mesothelioma Malignant TGLs = 3-15 ]

* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 237 TRT#: 3 SEX: Male DAY ON TEST: 294DOSE: 25 ppm DISP: Natural Death HISTO: 53855

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Colon * Intestine Large, Rectum * Islets, Pancreatic* Kidney * Larynx * Lung * Lymph Node, Mesenteric* Parathyroid Gland * Pituitary Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Testes * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum

OBSERVATIONS* Heart Cardiomyopathy Minimal* Liver Inflammation Chronic, Minimal* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy Minimal* Skin Subcut Tiss Sarcoma

[ Sarcoma TGLs = 1-14+15 ]

PRIMARY CAUSE OF DEATH - Skin Subcut Tiss Sarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 238 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53856

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Lymph Node, Mesenteric* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Islets, Pancreatic Hyperplasia Mild* Kidney Cyst Mild

Nephropathy Mild[ Cyst TGLs = 6-16 ]

* Liver Clear Cell FocusFatty Change Diffuse, Minimal

Bile Duct Hyperplasia MildInflammation Chronic, Mild

[ Clear Cell Focus TGLs = 3-6 ]* Lung Alveolar/Bronchiolar Adenoma* Lymph Node, Bronchial Ectasia Moderate

[ Ectasia TGLs = 1-3 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildInflammation Chronic Active, Marked

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 238 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53856

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Hyperplasia Mild* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 239 TRT#: 3 SEX: Male DAY ON TEST: 661DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53857

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland* Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate* Eye Cornea Inflammation Acute, Mild* Kidney Renal Tubule Carcinoma

Nephropathy Mild[ Carcinoma TGLs = 3-14 ]

* Liver Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Minimal

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 4-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 239 TRT#: 3 SEX: Male DAY ON TEST: 661DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53857

ORGAN AND ACCOUNTABLE SITE STATUS

Zymbal's Gland Carcinoma[ Carcinoma TGLs = 1-15 ]

PRIMARY CAUSE OF DEATH - Zymbal's Gland Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 240 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53858

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Mild

* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 1-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 241 TRT#: 3 SEX: Male DAY ON TEST: 694DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53859

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Pancreas* Parathyroid Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Degeneration Cystic, Mild

Eosinophilic FocusBile Duct Hyperplasia Mild

Inflammation Chronic, MinimalLeukemia MononuclearMixed Cell Focus

[ Eosinophilic Focus TGLs = 5,6,7,8,9,10-19+18+17+20+21+22 ][ Leukemia Mononuclear TGLs = 10-6 ][ Mixed Cell Focus TGLs = 10-22 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 241 TRT#: 3 SEX: Male DAY ON TEST: 694DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53859

ORGAN AND ACCOUNTABLE SITE STATUS

[ Necrosis TGLs = 3-18 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Hyperplasia Marked* Preputial Gland Carcinoma

[ Carcinoma TGLs = 1-14+15 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-17 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 4-9 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 242 TRT#: 3 SEX: Male DAY ON TEST: 607DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53860

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Mammary Gland * Parathyroid Gland * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal

Thrombosis Mild* Kidney Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-6 ]

* Lung Alveolar Epith Hyperplasia MinimalLeukemia Mononuclear

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy Minimal* Skin Subcut Tiss Sarcoma

[ Sarcoma TGLs = 1-14+15+16 ]* Spleen Leukemia Mononuclear* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 242 TRT#: 3 SEX: Male DAY ON TEST: 607DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53860

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 243 TRT#: 3 SEX: Male DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53861

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Epididymis Hyperplasia Mesothelium, Minimal* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Clear Cell Focus

Eosinophilic FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal[ Eosinophilic Focus TGLs = 2-6 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Hyperplasia Mild* Testes Bilateral, Interstit Cell Adenoma

Tunic Hyperplasia MinimalHyperplasia Mesothelium, Minimal

[ Adenoma TGLs = 1-9 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 244 TRT#: 3 SEX: Male DAY ON TEST: 492DOSE: 25 ppm DISP: Natural Death HISTO: 53862

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mesenteric * Pancreas * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Spleen * Stomach, Forestomach * Stomach, Glandular * Testes* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Moderate* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Mild

* Pituitary Gland Pars Distalis Hemorrhage Moderate[ Hemorrhage TGLs = 3-10 ]

* Skin Keratoacanthoma[ Keratoacanthoma TGLs = 2-14 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Hemorrhage

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 245 TRT#: 3 SEX: Male DAY ON TEST: 649DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53863

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Glandular* Testes * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Necrosis Moderate* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Malignant[ Pheochromocytoma Malignant TGLs = 3-14 ]

* Heart Cardiomyopathy Minimal* Kidney Nephropathy Marked

[ Nephropathy TGLs = 4-7+14 ]* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, MinimalNecrosis Marked

* Nose Turbinate Atrophy MildTurbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 5-10 ]

* Stomach, Forestomach Hyperplasia Squamous, Moderate

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 246 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53864

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Harderian Gland Hyperplasia Minimal* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 3-6 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Pancreas Atrophy Moderate* Parathyroid Gland Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma* Skin Keratoacanthoma

[ Keratoacanthoma TGLs = 1-14 ]* Testes Bilateral, Interstit Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 246 TRT#: 3 SEX: Male DAY ON TEST: 730DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53864

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 247 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53865

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Stomach, Forestomach* Stomach, Glandular * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Eye Cataract Mild* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Clear Cell Focus

Degeneration Cystic, ModerateBile Duct Hyperplasia Minimal

Inflammation Chronic, MildLeukemia Mononuclear

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 247 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53865

ORGAN AND ACCOUNTABLE SITE STATUS

Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Skin Keratoacanthoma

[ Keratoacanthoma TGLs = 1-14 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-16 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3,5-9 ]* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 248 TRT#: 3 SEX: Male DAY ON TEST: 560DOSE: 25 ppm DISP: Natural Death HISTO: 53866

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Mammary Gland

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Small, Jejunum

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-4+5 ]Lymph Node Renal Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-15 ]* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-14 ]* Lymph Node, Mesenteric Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 248 TRT#: 3 SEX: Male DAY ON TEST: 560DOSE: 25 ppm DISP: Natural Death HISTO: 53866

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 7-17 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4,5-16+18 ]* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3,8-9 ]* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 249 TRT#: 3 SEX: Male DAY ON TEST: 729DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53867

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Mild

[ Clear Cell Focus TGLs = 1-6 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 2-7 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Hyperplasia Mild* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3,4-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 250 TRT#: 3 SEX: Male DAY ON TEST: 723DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53868

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Eye * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Larynx * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Glandular* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland* Thymus

INSUFFICIENT TISSUE* Esophagus

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Epididymis Hyperplasia Mesothelium, Minimal* Harderian Gland Hyperplasia Minimal* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Islets, Pancreatic Carcinoma

[ Carcinoma TGLs = 4-14 ]* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Angiectasis Mild

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 250 TRT#: 3 SEX: Male DAY ON TEST: 723DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53868

ORGAN AND ACCOUNTABLE SITE STATUS

* Lung Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildInflammation Chronic Active, MildLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Mild

Peritoneum Mesothelium Hyperplasia Minimal* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Stomach, Forestomach Ulcer Minimal* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 401 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53719

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Larynx * Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Islets, Pancreatic Adenoma* Kidney Nephropathy Marked

[ Nephropathy TGLs = 8-7 ]* Liver Clear Cell Focus

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, MildMesothelioma MalignantNecrosis Minimal

[ Clear Cell Focus TGLs = 7-6 ][ Eosinophilic Focus TGLs = 7-6 ]

* Lung Alveolar Epith Hyperplasia Moderate* Lymph Node, Mediastinal Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 2-3 ]Mesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 5-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 401 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53719

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy MildPeritoneum Tunica Vaginal Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 4-14 ]* Pituitary Gland Pars Distalis Hyperplasia Mild

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 6-16 ]

* Testes Interstit Cell AdenomaMesothelioma Malignant

[ Adenoma TGLs = 3-9 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 402 TRT#: 5 SEX: Male DAY ON TEST: 705DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53720

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Esophagus * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Stomach, Glandular * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Granular Cell Tumor Benign

[ Granular Cell Tumor Benign TGLs = 14-20 ]* Epididymis Mesothelioma Malignant* Eye Retina Atrophy Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate* Liver Cyst Mild

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia MononuclearNecrosis Mild

[ Cyst TGLs = 12-21 ][ Leukemia Mononuclear TGLs = 11-6+21 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 16-4+5 ]

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Mesothelioma MalignantFat Necrosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 402 TRT#: 5 SEX: Male DAY ON TEST: 705DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53720

ORGAN AND ACCOUNTABLE SITE STATUS

[ Mesothelioma Malignant TGLs = 7-16 ][ Necrosis TGLs = 8-21 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

Thrombosis Mild* Pancreas Atrophy Moderate

Mesothelioma Malignant* Pituitary Gland Pars Distalis Hyperplasia Mild

[ Hyperplasia TGLs = 15-10 ]* Prostate Hyperplasia Mild

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 6-15 ]

* Skin Subcut Tiss FibromaSquamous Cell Papilloma

[ Fibroma TGLs = 13-17+18 ][ Squamous Cell Papilloma TGLs = 1-23 ]

* Spleen Leukemia MononuclearMesothelioma MalignantNecrosis Moderate

[ Leukemia Mononuclear TGLs = 9-22 ][ Necrosis TGLs = 10-22 ]

* Stomach, Forestomach Ulcer Mild* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 5-9 ][ Mesothelioma Malignant TGLs = 3,4-14+9 ]

* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 403 TRT#: 5 SEX: Male DAY ON TEST: 603DOSE: 50 ppm DISP: Natural Death HISTO: 53721

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Brain* Epididymis * Esophagus * Intestine Large, Colon * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mesenteric * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland * Preputial Gland

AUTO PRECLUDES DIAG.* Bone Marrow * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Lymph Node, Mediastinal * Seminal Vesicle * Thymus * Urinary Bladder

OBSERVATIONS* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Fatty Change Diffuse, Moderate

Inflammation Chronic, Minimal* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Prostate Inflammation Suppurative, Moderate* Testes Interstit Cell Adenoma

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis AdenomaAnimal Note: TGL 1 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 404 TRT#: 5 SEX: Male DAY ON TEST: 642DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53722

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Parathyroid Gland* Preputial Gland * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, MinimalMesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 6-16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Pancreas Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 5-6 ]Peritoneum Mesothelioma Malignant

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 7-10 ]

* Prostate Hyperplasia MildSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 2-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 404 TRT#: 5 SEX: Male DAY ON TEST: 642DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53722

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Mesothelioma Malignant* Testes Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 3-9 ][ Mesothelioma Malignant TGLs = 4-15 ]

PRIMARY CAUSE OF DEATH - Testes Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 405 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53723

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland * Parathyroid Gland* Thymus

INSUFFICIENT TISSUE* Pituitary Gland * Thyroid Gland

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 1-6 ]

* Lung Alveolar Epith Hyperplasia Moderate* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy Minimal* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 406 TRT#: 5 SEX: Male DAY ON TEST: 500DOSE: 50 ppm DISP: Natural Death HISTO: 53724

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Skin * Thymus * Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Mesothelioma Malignant* Liver Inflammation Chronic, Minimal

Necrosis Moderate[ Necrosis TGLs = 5-6 ]

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 4-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MinimalRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Marked

Thrombosis Marked* Pancreas Mesothelioma Malignant

Peritoneum Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 6-14 ]

* Pituitary Gland Pars Distalis Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 406 TRT#: 5 SEX: Male DAY ON TEST: 500DOSE: 50 ppm DISP: Natural Death HISTO: 53724

ORGAN AND ACCOUNTABLE SITE STATUS

* Seminal Vesicle Mesothelioma Malignant* Spleen Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 2,3-9 ]

* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 407 TRT#: 5 SEX: Male DAY ON TEST: 698DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53725

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Stomach, Forestomach * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Brain Histiocytic Sarcoma* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Histiocytic Sarcoma

Nephropathy Mild* Liver Histiocytic Sarcoma

[ Histiocytic Sarcoma TGLs = 8-6 ]* Lung Histiocytic Sarcoma

[ Histiocytic Sarcoma TGLs = 3-4+5 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, ModerateThrombosis Moderate

* Pancreas Atrophy Marked* Pituitary Gland Pars Distalis Adenoma* Prostate Inflammation Suppurative, Moderate* Skin Cyst Epithelial Inclusion

Subcut Tiss Histiocytic Sarcoma[ Cyst Epithelial Inclusion TGLs = 10-19 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 407 TRT#: 5 SEX: Male DAY ON TEST: 698DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53725

ORGAN AND ACCOUNTABLE SITE STATUS

[ Histiocytic Sarcoma TGLs = 9-14+15+16 ]* Spleen Hematopoietic Cell Proliferation Marked

[ Hematopoietic Cell Proliferation TGLs = 6-18 ]* Stomach, Glandular Necrosis Minimal* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 5-9 ][ Mesothelioma Malignant TGLs = 4-19 ]

* Thyroid Gland C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Skin Subcut Tiss Histiocytic Sarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 163

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ANIMAL ID: 408 TRT#: 5 SEX: Male DAY ON TEST: 660DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53726

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Mammary Gland * Parathyroid Gland Peripheral Nerve * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin

Spinal Cord * Spleen * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate

[ Nephropathy TGLs = 3-7 ]* Liver Fatty Change Diffuse, Moderate

Inflammation Chronic, Mild[ Fatty Change TGLs = 6-6 ]

* Lung Alveolar Epith Hyperplasia MinimalMesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 164

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ANIMAL ID: 408 TRT#: 5 SEX: Male DAY ON TEST: 660DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53726

ORGAN AND ACCOUNTABLE SITE STATUS

* Testes Atrophy MarkedMesothelioma Malignant

[ Mesothelioma Malignant TGLs = 2-15 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 409 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53727

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Mammary Gland* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Medulla Bilateral Pheochromocytoma Benign* Heart Cardiomyopathy Mild* Islets, Pancreatic Adenoma* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Clear Cell Focus

Eosinophilic FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, MildLeukemia MononuclearMixed Cell Focus

[ Clear Cell Focus TGLs = 5-17 ][ Eosinophilic Focus TGLs = 3,4,6-15+16+18 ][ Mixed Cell Focus TGLs = 2-14 ]

* Lung Alveolar Epith Hyperplasia MinimalLeukemia Mononuclear

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MarkedInflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 409 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53727

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Leukemia Mononuclear* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 410 TRT#: 5 SEX: Male DAY ON TEST: 661DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53728

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Jejunum * Larynx * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Islets, Pancreatic Hyperplasia Mild* Kidney Leukemia Mononuclear

Nephropathy Moderate[ Leukemia Mononuclear TGLs = 9-7 ]

* Liver Inflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia MononuclearLymph Node Deep Cervical Leukemia Mononuclear

Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-14 ][ Leukemia Mononuclear TGLs = 12-18 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 410 TRT#: 5 SEX: Male DAY ON TEST: 661DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53728

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 13-16 ]Mesentery Mesothelioma Malignant

Fat Necrosis Mild[ Necrosis TGLs = 10-17 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 11-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5,6,7-15 ]

* Stomach, Glandular Leukemia Mononuclear* Testes Interstit Cell Hyperplasia Mild

Mesothelioma Malignant[ Hyperplasia TGLs = 14-9 ][ Mesothelioma Malignant TGLs = 8-9 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 3-3 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 411 TRT#: 5 SEX: Male DAY ON TEST: 586DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53729

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Pancreas * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Esophagus Carcinoma Metastatic (Thyroid Gland)* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate

[ Nephropathy TGLs = 5-7 ]* Larynx Carcinoma Metastatic (Thyroid Gland)* Liver Degeneration Cystic, Mild

Inflammation Chronic, Minimal* Lung Carcinoma Metastatic (Thyroid Gland)

[ Carcinoma TGLs = 3-4+5 ]Lymph Node Pancreatic Congestion Mild

[ Congestion TGLs = 6-6 ]* Lymph Node, Mesenteric Congestion Mild

[ Congestion TGLs = 9-8 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 8-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 411 TRT#: 5 SEX: Male DAY ON TEST: 586DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53729

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Testes Interstit Cell AdenomaAtrophy Moderate

[ Adenoma TGLs = 7-9 ]* Thymus Carcinoma Metastatic (Thyroid Gland)

[ Carcinoma TGLs = 2-3 ]* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 1-3 ]* Trachea Carcinoma Metastatic (Thyroid Gland)

PRIMARY CAUSE OF DEATH - Thyroid Gland C Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 412 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53730

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Minimal* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild

[ Nephropathy TGLs = 3-7 ]* Liver Clear Cell Focus

Inflammation Chronic, Minimal* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma* Skin Cyst Epithelial Inclusion Mild

Keratoacanthoma[ Keratoacanthoma TGLs = 1-14+15 ]

* Testes Bilateral, Interstit Cell AdenomaMesothelioma Malignant

[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 412 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53730

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 413 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53731

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland* Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate

[ Nephropathy TGLs = 4-7 ]* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 3-6 ]

* Lung Alveolar Epith Hyperplasia MinimalAlveolar Epith Metaplasia Squamous, Mild

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Adenoma* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 413 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53731

ORGAN AND ACCOUNTABLE SITE STATUS

* Testes Interstit Cell AdenomaAtrophy Moderate

[ Adenoma TGLs = 2-9 ][ Atrophy TGLs = 1-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 414 TRT#: 5 SEX: Male DAY ON TEST: 642DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53732

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Minimal

Leukemia MononuclearPheochromocytoma Benign

* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild

Thrombosis Moderate[ Thrombosis TGLs = 12-6 ]

* Kidney Infarct ModerateLeukemia MononuclearNephropathy Mild

[ Infarct TGLs = 11-7 ]* Liver Eosinophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2,4,3-6+14 ]* Lung Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 414 TRT#: 5 SEX: Male DAY ON TEST: 642DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53732

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 10-8 ]Mesentery Mesothelioma Malignant

Fat Necrosis Mild[ Necrosis TGLs = 7-16 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

Thrombosis Mild* Pituitary Gland Pars Distalis Hyperplasia Moderate* Spleen Leukemia Mononuclear

Mesothelioma Malignant[ Leukemia Mononuclear TGLs = 5-15 ][ Mesothelioma Malignant TGLs = 6-15 ]

* Testes Bilateral, Interstit Cell AdenomaMesothelioma Malignant

[ Adenoma TGLs = 8-9 ][ Mesothelioma Malignant TGLs = 9-17 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 415 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53733

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Degeneration Cystic, Moderate

Eosinophilic FocusBile Duct Hyperplasia Mild

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 1-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 415 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53733

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Marked* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 6-10 ]* Prostate Hyperplasia Minimal* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 4-9 ][ Atrophy TGLs = 5-9 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Adenoma

C Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 416 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53734

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Bronchial * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Bilateral Pheochromocytoma Benign* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Moderate* Kidney Renal Tubule Carcinoma

Nephropathy Mild[ Carcinoma TGLs = 8-17 ]

* Liver Fatty Change Diffuse, MinimalHepatodiaphragmatic Nodule

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalMesothelioma MalignantMixed Cell Focus

[ Hepatodiaphragmatic Nodule TGLs = 7-19 ][ Mixed Cell Focus TGLs = 6-6 ]

* Lung Carcinoma Metastatic (Kidney)Mesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 5-15 ]* Nose Turbinate Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 416 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53734

ORGAN AND ACCOUNTABLE SITE STATUS

Foreign BodyTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Mesothelioma Malignant* Pituitary Gland Pars Distalis Adenoma

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 4-14 ]

* Stomach, Forestomach Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 2-9 ][ Mesothelioma Malignant TGLs = 3-16+9 ]

* Thyroid Gland C Cell Hyperplasia MinimalFollicular Cel Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 417 TRT#: 5 SEX: Male DAY ON TEST: 296DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53735

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Parathyroid Gland* Pituitary Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Testes * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, Minimal* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Minimal

PRIMARY CAUSE OF DEATH - UNCERTAIN

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 418 TRT#: 5 SEX: Male DAY ON TEST: 418DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53736

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Testes * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Minimal* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Prostate Inflammation Suppurative, Mild

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 419 TRT#: 5 SEX: Male DAY ON TEST: 666DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53737

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-7 ]

* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-1 ]* Heart Leukemia Mononuclear* Kidney Renal Tubule Hyperplasia Minimal

Leukemia MononuclearRenal Tubule Necrosis Minimal

Nephropathy Mild* Liver Degeneration Cystic, Mild

Bile Duct Hyperplasia MildInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-4+5 ]Lymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 8-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 419 TRT#: 5 SEX: Male DAY ON TEST: 666DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53737

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-3 ]

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 10-16 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-17 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Capsule Hyperplasia Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-14 ]

* Stomach, Glandular Leukemia Mononuclear* Testes Interstit Cell Adenoma

Tunic Hyperplasia MinimalMesothelioma Malignant

[ Adenoma TGLs = 9-9 ]* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 420 TRT#: 5 SEX: Male DAY ON TEST: 557DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53738

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Mammary Gland * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Intestine Large, Cecum Arteriole Inflammation Minimal* Intestine Large, Colon Arteriole Inflammation Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Fatty Change Diffuse, ModerateInflammation Chronic, Minimal

[ Fatty Change TGLs = 1-6 ]* Lung Alveolar Epith Hyperplasia Mild* Lymph Node, Bronchial Congestion Mild

[ Congestion TGLs = 3-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Prostate Inflammation Suppurative, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 186

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ANIMAL ID: 420 TRT#: 5 SEX: Male DAY ON TEST: 557DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53738

ORGAN AND ACCOUNTABLE SITE STATUS

* Skin Inflammation Acute, Moderate* Testes Atrophy Moderate

Interstit Cell Hyperplasia MinimalArteriole Inflammation Minimal

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 421 TRT#: 5 SEX: Male DAY ON TEST: 502DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53739

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Preputial Gland* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Thymus * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

INSUFFICIENT TISSUE* Esophagus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Blood Vessel Aorta Mineralization Moderate* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Transit Epithe Hyperplasia Moderate

Inflammation Suppurative, MarkedNephropathy Marked

[ Inflammation TGLs = 5-7 ]* Liver Inflammation Chronic, Minimal* Lung Mineralization Mild* Lymph Node, Mediastinal Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 2-3 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Mild* Parathyroid Gland Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 421 TRT#: 5 SEX: Male DAY ON TEST: 502DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53739

ORGAN AND ACCOUNTABLE SITE STATUS

Penis Inflammation Suppurative, Marked[ Inflammation TGLs = 6-14 ]

* Pituitary Gland Pars Distalis Hyperplasia Moderate* Prostate Inflammation Suppurative, Moderate* Stomach, Glandular Mineralization Marked* Testes Atrophy Marked

[ Atrophy TGLs = 3-9 ]* Thyroid Gland C Cell Hyperplasia Mild* Urinary Bladder Transit Epithe Hyperplasia Moderate

Inflammation Chronic Active, Mild

PRIMARY CAUSE OF DEATH - Penis Inflammation

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 422 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53740

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Marked

[ Nephropathy TGLs = 5-7 ]* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalInflammation Chronic, MinimalMixed Cell Focus

[ Clear Cell Focus TGLs = 2-6 ][ Mixed Cell Focus TGLs = 2,4-6+14 ]

* Lymph Node, Bronchial Ectasia Marked[ Ectasia TGLs = 1-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Moderate* Parathyroid Gland Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 422 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53740

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 423 TRT#: 5 SEX: Male DAY ON TEST: 689DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53741

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Bronchial * Lymph Node, Mesenteric * Mammary Gland* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Benign* Epididymis Mesothelioma Malignant* Heart Thrombosis Moderate

[ Thrombosis TGLs = 3-14 ]* Intestine Large, Rectum Thrombosis Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MildBile Duct Hyperplasia Mild

Inflammation Chronic, MildBile Duct Inflammation Suppurative, Marked

Necrosis Moderate[ Inflammation TGLs = 6-6+15 ][ Necrosis TGLs = 5-15 ]

* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 423 TRT#: 5 SEX: Male DAY ON TEST: 689DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53741

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, ModerateThrombosis Marked

* Pancreas Duct CarcinomaInflammation Chronic Active, Marked

[ Carcinoma TGLs = 8-17 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 7-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pancreas Duct Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 424 TRT#: 5 SEX: Male DAY ON TEST: 591DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53742

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Eye* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Preputial Gland* Salivary Glands * Seminal Vesicle * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Mammary Gland * Skin

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Harderian Gland Leukemia Mononuclear* Heart Cardiomyopathy Mild

Leukemia Mononuclear* Intestine Large, Cecum Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Bile Duct Hyperplasia Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-6 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Lymph Node, Mandibular Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-3 ]* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 194

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ANIMAL ID: 424 TRT#: 5 SEX: Male DAY ON TEST: 591DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53742

ORGAN AND ACCOUNTABLE SITE STATUS

[ Necrosis TGLs = 6-16 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, ModerateLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked* Pancreas Atrophy Minimal

Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Prostate Inflammation Suppurative, Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-14 ]* Testes Interstit Cell Hyperplasia Minimal* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 425 TRT#: 5 SEX: Male DAY ON TEST: 683DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53743

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Parathyroid Gland * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Islets, Pancreatic Carcinoma

[ Carcinoma TGLs = 5-14 ]* Kidney Nephropathy Mild* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear* Lung Alveolar/Bronchiolar Adenoma

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-4+5 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Marked* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3,4-14 ]* Testes Bilateral, Interstit Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 196

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ANIMAL ID: 425 TRT#: 5 SEX: Male DAY ON TEST: 683DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53743

ORGAN AND ACCOUNTABLE SITE STATUS

Mesothelioma Malignant[ Adenoma TGLs = 2-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 197

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ANIMAL ID: 426 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53744

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Bilateral Hyperplasia Moderate* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Marked* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, MildLeukemia MononuclearMixed Cell Focus

* Lung Alveolar Epith Hyperplasia MildLeukemia Mononuclear

* Lymph Node, Bronchial Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Carcinoma

[ Carcinoma TGLs = 1-17 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 198

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ANIMAL ID: 426 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53744

ORGAN AND ACCOUNTABLE SITE STATUS

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Marked

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma* Skin Trichoepithelioma

[ Trichoepithelioma TGLs = 2-18 ]* Spleen Leukemia Mononuclear* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 4-9 ][ Mesothelioma Malignant TGLs = 5-16 ]

* Thymus Leukemia Mononuclear* Thyroid Gland Follicular Cel Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 199

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ANIMAL ID: 427 TRT#: 5 SEX: Male DAY ON TEST: 668DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53745

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Islets, Pancreatic* Larynx * Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland* Preputial Gland * Salivary Glands * Skin * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Benign* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild

Thrombosis Moderate* Intestine Large, Cecum Mesothelioma Malignant* Intestine Small, Jejunum Mesothelioma Malignant* Kidney Nephropathy Moderate* Liver Fatty Change Diffuse, Minimal

Necrosis Moderate[ Necrosis TGLs = 4-6 ]

* Lung Thrombosis MinimalMesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 7-16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

Thrombosis Marked* Pancreas Mesothelioma Malignant* Pituitary Gland Pars Distalis Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 200

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ANIMAL ID: 427 TRT#: 5 SEX: Male DAY ON TEST: 668DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53745

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Mesothelioma Malignant* Seminal Vesicle Mesothelioma Malignant

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 3-14 ]

* Spleen Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 6-9 ][ Mesothelioma Malignant TGLs = 5-15 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 201

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ANIMAL ID: 428 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53746

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 1-6 ]

* Lung Alveolar Epith Hyperplasia MinimalMesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Moderate* Pituitary Gland Pars Distalis Hyperplasia Moderate* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 202

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ANIMAL ID: 429 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53747

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, ModerateBile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalMesentery Mesothelioma Malignant

Fat Necrosis Mild[ Mesothelioma Malignant TGLs = 2-14 ][ Necrosis TGLs = 2-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 203

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ANIMAL ID: 429 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53747

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 1-10 ]* Testes Mesothelioma Malignant* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 204

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ANIMAL ID: 430 TRT#: 5 SEX: Male DAY ON TEST: 535DOSE: 50 ppm DISP: Natural Death HISTO: 53748

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Islets, Pancreatic* Lung * Lymph Node, Mesenteric * Parathyroid Gland * Pituitary Gland* Preputial Gland * Salivary Glands * Skin * Thymus* Thyroid Gland * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Adrenal Cortex * Adrenal Medulla * Bone Marrow * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Kidney* Larynx * Stomach, Glandular * Trachea

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild

Thrombosis Moderate[ Thrombosis TGLs = 3-6 ]

* Liver Inflammation Chronic, MinimalNecrosis Marked

[ Necrosis TGLs = 4-6 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateThrombosis Marked

* Pancreas Mesothelioma MalignantPeritoneum Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 7-16 ]* Prostate Mesothelioma Malignant* Seminal Vesicle Mesothelioma Malignant

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 6-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 430 TRT#: 5 SEX: Male DAY ON TEST: 535DOSE: 50 ppm DISP: Natural Death HISTO: 53748

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Testes Interstit Cell Adenoma

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 5-9+14 ]

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 431 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53749

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Mammary Gland * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Glandular* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Bilateral Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Leukemia Mononuclear* Islets, Pancreatic Carcinoma* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Eosinophilic Focus

Bile Duct Hyperplasia MildInflammation Chronic, MinimalLeukemia Mononuclear

[ Eosinophilic Focus TGLs = 4,5,6,8-6+14+15+7 ]* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 10-4+5 ]Lymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 9-15 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 431 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53749

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Hyperplasia Moderate

Leukemia Mononuclear* Spleen Fibrosis Mild

Leukemia Mononuclear[ Fibrosis TGLs = 3-14 ][ Leukemia Mononuclear TGLs = 2-14 ]

* Stomach, Forestomach Hyperplasia Squamous, Minimal* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]* Thymus Leukemia Mononuclear

Animal Note: TGL 7 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 432 TRT#: 5 SEX: Male DAY ON TEST: 637DOSE: 50 ppm DISP: Natural Death HISTO: 53750

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Harderian Gland * Intestine Large, Colon* Intestine Large, Rectum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Pancreas * Parathyroid Gland* Pituitary Gland * Preputial Gland * Prostate * Salivary Glands* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum

OBSERVATIONS* Epididymis Mesothelioma Malignant* Eye Cataract Minimal* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, Mild* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MinimalInflammation Chronic Active, Marked

Olfactory Epi Metaplasia Respiratory, ModerateSarcoma

[ Sarcoma TGLs = 5-11+12 ]* Seminal Vesicle Hyperplasia Mild* Skin Trichoepithelioma

[ Trichoepithelioma TGLs = 2-15 ]* Testes Atrophy Mild

Interstit Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 432 TRT#: 5 SEX: Male DAY ON TEST: 637DOSE: 50 ppm DISP: Natural Death HISTO: 53750

ORGAN AND ACCOUNTABLE SITE STATUS

Mesothelioma Malignant[ Atrophy TGLs = 4-9 ]

PRIMARY CAUSE OF DEATH - Nose Sarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 433 TRT#: 5 SEX: Male DAY ON TEST: 555DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53751

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Parathyroid Gland* Salivary Glands * Seminal Vesicle * Skin * Stomach, Glandular* Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland* Thymus

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Thrombosis Marked[ Thrombosis TGLs = 3-14+4 ]

* Kidney Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Necrosis Mild* Lung Thrombosis Mild

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 5-16 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

Thrombosis Moderate* Pancreas Mesothelioma Malignant* Pituitary Gland Pars Distalis Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 433 TRT#: 5 SEX: Male DAY ON TEST: 555DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53751

ORGAN AND ACCOUNTABLE SITE STATUS

* Preputial Gland Carcinoma[ Carcinoma TGLs = 4-9 ]

* Prostate Inflammation Suppurative, MinimalSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 9-15 ]* Spleen Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 8-6 ]* Stomach, Forestomach Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 6-9 ][ Mesothelioma Malignant TGLs = 7-17 ]

* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Heart Thrombosis

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 434 TRT#: 5 SEX: Male DAY ON TEST: 574DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53752

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Stomach, Forestomach * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-6 ]

* Lung Leukemia MononuclearAlveolar Epith Metaplasia Mucous, Mild

[ Leukemia Mononuclear TGLs = 2-4+5 ]Lymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-14 ]* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 434 TRT#: 5 SEX: Male DAY ON TEST: 574DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53752

ORGAN AND ACCOUNTABLE SITE STATUS

Thrombosis Moderate* Pancreas Atrophy Mild* Skin Keratoacanthoma

[ Keratoacanthoma TGLs = 1-16 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4,5-14 ]* Stomach, Glandular Ulcer Moderate

[ Ulcer TGLs = 9-15 ]* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 8-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 435 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53753

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Fatty Change Diffuse, MildInflammation Chronic, Minimal

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Testes Interstit Cell AdenomaAtrophy ModerateMesothelioma Malignant

[ Adenoma TGLs = 1-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 215

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ANIMAL ID: 436 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53754

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Spleen * Stomach, Forestomach* Stomach, Glandular * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalInflammation Chronic, MinimalMixed Cell Focus

* Lung Alveolar/Bronchiolar CarcinomaAlveolar Epith Hyperplasia Mild

[ Alveolar/Bronchiolar Carcinoma TGLs = 2-5+16 ][ Hyperplasia TGLs = 4-4 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma* Skin Keratoacanthoma

[ Keratoacanthoma TGLs = 1-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 436 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53754

ORGAN AND ACCOUNTABLE SITE STATUS

* Testes Interstit Cell Adenoma[ Adenoma TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 437 TRT#: 5 SEX: Male DAY ON TEST: 423DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53755

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Pituitary Gland * Preputial Gland* Prostate * Salivary Glands * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Kidney Nephropathy Minimal

[ Nephropathy TGLs = 2-7 ]* Liver Inflammation Chronic, Minimal* Lung Inflammation Chronic Active, Minimal

[ Inflammation TGLs = 3,4-14+5 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Minimal* Seminal Vesicle Adenoma* Skin Inflammation Chronic Active, Marked

[ Inflammation TGLs = 1-9+17 ]* Testes Interstit Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Skin Inflammation

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 218

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ANIMAL ID: 438 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53756

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Pancreas * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Heart Cardiomyopathy Minimal* Islets, Pancreatic Carcinoma

[ Carcinoma TGLs = 5-14 ]* Kidney Nephropathy Moderate* Liver Inflammation Chronic, Mild

Leukemia Mononuclear* Lung Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 219

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ANIMAL ID: 438 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53756

ORGAN AND ACCOUNTABLE SITE STATUS

Necrosis Mild[ Leukemia Mononuclear TGLs = 2-14 ][ Necrosis TGLs = 3-14 ]

* Testes Interstit Cell Adenoma[ Adenoma TGLs = 6-9 ]

* Thyroid Gland C Cell AdenomaC Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 439 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53757

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Harderian Gland Hyperplasia Moderate* Heart Cardiomyopathy Mild* Kidney Nephropathy Marked

[ Nephropathy TGLs = 4-7 ]* Liver Degeneration Cystic, Minimal

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, MildMixed Cell Focus

[ Eosinophilic Focus TGLs = 3-6 ][ Mixed Cell Focus TGLs = 3-6 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, MarkedOlfactory Epi Metaplasia Squamous, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 439 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53757

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Hyperplasia Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 1-14+15+16 ]* Testes Interstit Cell Adenoma

Atrophy Marked[ Adenoma TGLs = 2-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 440 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53758

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Larynx * Lung * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

[ Hyperplasia TGLs = 8-7 ]* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Islets, Pancreatic Hyperplasia Moderate* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Degeneration Cystic, MildBile Duct Hyperplasia Minimal

Inflammation Chronic, Mild[ Clear Cell Focus TGLs = 7-6 ]

* Lymph Node, Bronchial Ectasia Mild[ Ectasia TGLs = 4-22 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MinimalRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 440 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53758

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 6-10 ]* Prostate Inflammation Suppurative, Moderate* Skin Subcut Tiss Fibroma Multiple

[ Fibroma TGLs = 1,3-14+15+16+18+19+20 ]* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 9-24 ]

* Thyroid Gland Follicular Cel Carcinoma[ Carcinoma TGLs = 5-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 441 TRT#: 5 SEX: Male DAY ON TEST: 617DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53759

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-15 ]Mesentery Inflammation Chronic Active, Mild

Fat Necrosis Mild[ Inflammation TGLs = 7-16 ][ Necrosis TGLs = 4-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 441 TRT#: 5 SEX: Male DAY ON TEST: 617DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53759

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Moderate

Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Moderate

Leukemia Mononuclear[ Hyperplasia TGLs = 1-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-14 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 5-9 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 442 TRT#: 5 SEX: Male DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53760

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Parathyroid Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusDegeneration Cystic, Minimal

Bile Duct Hyperplasia MinimalInflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Alveolar Epith Hyperplasia Mild

Leukemia Mononuclear[ Hyperplasia TGLs = 5-5 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 442 TRT#: 5 SEX: Male DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53760

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Marked* Pancreas Atrophy Mild

Hyperplasia Mild* Pituitary Gland Pars Distalis Hyperplasia Mild* Preputial Gland Adenoma

[ Adenoma TGLs = 1-14 ]* Spleen Leukemia Mononuclear* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 2,3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 443 TRT#: 5 SEX: Male DAY ON TEST: 596DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53761

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 8-6 ]* Lung Leukemia Mononuclear

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-14 ]

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-7 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 229

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ANIMAL ID: 443 TRT#: 5 SEX: Male DAY ON TEST: 596DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53761

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MinimalLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Leukemia Mononuclear* Pituitary Gland Leukemia Mononuclear* Prostate Inflammation Suppurative, Mild

Leukemia Mononuclear* Spleen Fibrosis Mild

Leukemia Mononuclear[ Fibrosis TGLs = 2-14 ][ Leukemia Mononuclear TGLs = 1-14 ]

* Stomach, Forestomach Leukemia Mononuclear* Stomach, Glandular Leukemia Mononuclear

Necrosis Minimal[ Necrosis TGLs = 9-15 ]

* Testes Interstit Cell AdenomaAtrophy ModerateMesothelioma Malignant

[ Adenoma TGLs = 3-9 ]* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 444 TRT#: 5 SEX: Male DAY ON TEST: 563DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53762

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Mammary Gland * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Minimal* Intestine Large, Cecum Leukemia Mononuclear* Intestine Large, Colon Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Renal Tubule Necrosis MildNephropathy Mild

[ Necrosis TGLs = 5-17 ]* Liver Bile Duct Hyperplasia Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-6 ]

* Lung Leukemia MononuclearLymph Node Deep Cervical Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-15 ]* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-18 ]* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 231

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ANIMAL ID: 444 TRT#: 5 SEX: Male DAY ON TEST: 563DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53762

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Moderate

Thrombosis Moderate* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Marked

Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-16 ]* Stomach, Forestomach Hyperplasia Squamous, Moderate

Leukemia Mononuclear* Stomach, Glandular Leukemia Mononuclear* Testes Interstit Cell Hyperplasia Mild* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 232

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ANIMAL ID: 445 TRT#: 5 SEX: Male DAY ON TEST: 575DOSE: 50 ppm DISP: Natural Death HISTO: 53763

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Harderian Gland * Islets, Pancreatic* Kidney * Larynx * Lung * Lymph Node, Mesenteric* Pancreas * Parathyroid Gland * Pituitary Gland * Salivary Glands* Skin * Stomach, Forestomach * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

AUTO PRECLUDES DIAG.* Eye * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Seminal Vesicle

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Thrombosis Mild[ Thrombosis TGLs = 2-14 ]

* Liver Inflammation Chronic, MildNecrosis Moderate

[ Necrosis TGLs = 7-6 ]* Lymph Node, Mediastinal Congestion Moderate

[ Congestion TGLs = 3-3 ]Mesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 8-17 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Minimal

Thrombosis Marked* Preputial Gland Carcinoma

[ Carcinoma TGLs = 4-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 233

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ANIMAL ID: 445 TRT#: 5 SEX: Male DAY ON TEST: 575DOSE: 50 ppm DISP: Natural Death HISTO: 53763

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Hyperplasia Mild* Spleen Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 6-6 ]* Stomach, Glandular Necrosis Minimal

[ Necrosis TGLs = 10-10+16 ]* Testes Interstit Cell Adenoma

Atrophy MarkedMesothelioma Malignant

[ Adenoma TGLs = 5-9 ][ Mesothelioma Malignant TGLs = 9-16 ]

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 234

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ANIMAL ID: 446 TRT#: 5 SEX: Male DAY ON TEST: 617DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53764

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Degeneration Cystic, MildInflammation Chronic, Minimal

Lymph Node Pancreatic Infiltration Cellular Histiocyte, Mild[ Infiltration Cellular TGLs = 7-6 ]

* Lymph Node, Mesenteric Hyperplasia Lymphoid, Mild[ Hyperplasia TGLs = 6-8 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-7 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Skin Subcut Tiss Schwannoma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 235

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ANIMAL ID: 446 TRT#: 5 SEX: Male DAY ON TEST: 617DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53764

ORGAN AND ACCOUNTABLE SITE STATUS

[ Schwannoma Malignant TGLs = 1-14 ]* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]

PRIMARY CAUSE OF DEATH - Skin Subcut Tiss Schwannoma MalignantAnimal Note: TGL 3 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 236

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ANIMAL ID: 447 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53765

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Islets, Pancreatic Adenoma* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Inflammation Chronic, Mild[ Clear Cell Focus TGLs = 5-6 ]

* Lung Alveolar/Bronchiolar Adenoma[ Alveolar/Bronchiolar Adenoma TGLs = 1-5 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, MarkedRespirat Epith Metaplasia Squamous, Mild

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Prostate Hyperplasia Mild* Testes Interstit Cell Adenoma

Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 237

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ANIMAL ID: 447 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53765

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 2,3-9 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 238

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ANIMAL ID: 448 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53766

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Parathyroid Gland * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Benign* Epididymis Hyperplasia Mesothelium, Minimal* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, Mild[ Clear Cell Focus TGLs = 3-6 ]

* Lung Alveolar/Bronchiolar AdenomaAlveolar Epith Hyperplasia Mild

[ Hyperplasia TGLs = 2-5 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Moderate* Pituitary Gland Pars Distalis Adenoma* Preputial Gland Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 448 TRT#: 5 SEX: Male DAY ON TEST: 730DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53766

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 1-14 ]* Prostate Hyperplasia Mild* Testes Bilateral, Interstit Cell Adenoma

Tunic Hyperplasia Minimal[ Adenoma TGLs = 4-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 449 TRT#: 5 SEX: Male DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53767

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Lung * Lymph Node, Mesenteric* Parathyroid Gland * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

INSUFFICIENT TISSUE* Adrenal Medulla

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Islets, Pancreatic Hyperplasia Moderate* Kidney Nephropathy Moderate* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MildMixed Cell Focus

[ Clear Cell Focus TGLs = 4-6 ][ Mixed Cell Focus TGLs = 4-6 ]

* Nose Respirat Epith AdenomaTurbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 449 TRT#: 5 SEX: Male DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53767

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Preputial Gland Carcinoma

[ Carcinoma TGLs = 1-14 ]* Prostate Hyperplasia Mild* Testes Interstit Cell Adenoma

Atrophy Moderate[ Adenoma TGLs = 2-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 450 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53768

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Moderate* Islets, Pancreatic Carcinoma

[ Carcinoma TGLs = 3-14 ]* Kidney Nephropathy Mild* Liver Clear Cell Focus

Inflammation Chronic, MildMixed Cell Focus

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 1-15 ]

* Nose Turbinate Atrophy ModerateForeign Body

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 450 TRT#: 5 SEX: Male DAY ON TEST: 729DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53768

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 2-10 ]* Testes Interstit Cell Adenoma* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 601 TRT#: 7 SEX: Male DAY ON TEST: 701DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53619

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Mammary Gland* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Basophilic Focus

Fatty Change Diffuse, ModerateBile Duct Hyperplasia Mild

Inflammation Chronic, Mild[ Basophilic Focus TGLs = 8,10,9-6+17 ]

Lymph Node Pancreatic Hyperplasia Lymphoid, Minimal[ Hyperplasia TGLs = 12-17 ]

* Lymph Node, Mediastinal Hyperplasia Lymphoid, Mild[ Hyperplasia TGLs = 1-3 ]

* Lymph Node, Mesenteric Hyperplasia Lymphoid, Mild[ Hyperplasia TGLs = 13-8 ]

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 5-15 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 601 TRT#: 7 SEX: Male DAY ON TEST: 701DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53619

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy MinimalPeritoneum Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 6-16 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 11-10 ]* Spleen Mesothelioma Malignant* Testes Interstit Cell Adenoma

Atrophy ModerateMesothelioma Malignant

[ Adenoma TGLs = 7-9 ][ Mesothelioma Malignant TGLs = 3,4-14+9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 602 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53620

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Testes* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Islets, Pancreatic Carcinoma* Kidney Nephropathy Moderate* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, MildMixed Cell Focus

[ Basophilic Focus TGLs = 3-6 ][ Mixed Cell Focus TGLs = 3-6 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-15+16 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Marked

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 602 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53620

ORGAN AND ACCOUNTABLE SITE STATUS

* Thymus Infiltration Cellular Polymorphnuclr, Moderate* Thyroid Gland C Cell Carcinoma

[ Carcinoma TGLs = 1-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 603 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53621

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Mammary Gland* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Hepatodiaphragmatic NoduleInflammation Chronic, ModerateMixed Cell Focus

[ Clear Cell Focus TGLs = 6-6 ][ Hepatodiaphragmatic Nodule TGLs = 2-7 ][ Mixed Cell Focus TGLs = 3-6 ]

* Lymph Node, Mesenteric Ectasia Moderate[ Ectasia TGLs = 4-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 249

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ANIMAL ID: 603 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53621

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Atrophy MinimalInflammation Chronic Active, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 5-10 ]

* Testes Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 604 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53622

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Benign* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate

[ Nephropathy TGLs = 9-7 ]* Liver Clear Cell Focus

Fatty Change Diffuse, ModerateBile Duct Hyperplasia Minimal

Inflammation Chronic, Mild[ Clear Cell Focus TGLs = 8-6 ]

* Lung Alveolar Epith Hyperplasia Moderate[ Hyperplasia TGLs = 3-5 ]

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 6-17 ]

* Nose Respirat Epith AdenomaTurbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 251

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ANIMAL ID: 604 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53622

ORGAN AND ACCOUNTABLE SITE STATUS

Respirat Epith Hyperplasia MildInflammation Chronic Active, Marked

Olfactory Epi Metaplasia Respiratory, Marked* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 7-10 ]Skeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 2-16 ]* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 1-14 ]* Spleen Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 4-9 ][ Mesothelioma Malignant TGLs = 5-9+18 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 605 TRT#: 7 SEX: Male DAY ON TEST: 635DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53623

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Testes* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, ModerateMesentery Fat Necrosis Mild

[ Necrosis TGLs = 2,4-14+15 ]* Nose Respirat Epith Adenoma

Turbinate Atrophy MarkedTurbinate Hyperostosis Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Thyroid Gland C Cell Carcinoma[ Carcinoma TGLs = 1-3 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 606 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53624

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Bilateral Pheochromocytoma Benign[ Pheochromocytoma Benign TGLs = 6-7 ]

* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Marked[ Nephropathy TGLs = 5-7 ]

* Liver Degeneration Cystic, MildEosinophilic Focus

Bile Duct Hyperplasia MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 8-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 7-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 254

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ANIMAL ID: 606 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53624

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Spleen Fibrosis Moderate

Leukemia Mononuclear[ Fibrosis TGLs = 3-14 ][ Leukemia Mononuclear TGLs = 2-14 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 1-9 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

Follicular Cel Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 607 TRT#: 7 SEX: Male DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53625

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Glandular* Testes * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Moderate* Kidney Nephropathy Marked

[ Nephropathy TGLs = 2-7 ]* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, ModerateInflammation Chronic, MildNecrosis Mild

[ Necrosis TGLs = 4-6 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Stomach, Forestomach Hyperplasia Squamous, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 607 TRT#: 7 SEX: Male DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53625

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 608 TRT#: 7 SEX: Male DAY ON TEST: 495DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53626

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Lung* Lymph Node, Bronchial * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Larynx Metaplasia Squamous, Mild* Liver Fatty Change Diffuse, Moderate

Inflammation Chronic, Moderate[ Fatty Change TGLs = 4-6 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-14 ]

* Nose Turbinate Atrophy MarkedForeign Body

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Testes Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 608 TRT#: 7 SEX: Male DAY ON TEST: 495DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53626

ORGAN AND ACCOUNTABLE SITE STATUS

Mesothelioma Malignant* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 609 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53627

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Clear Cell Focus

Degeneration Cystic, MildEosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, ModerateLeukemia Mononuclear

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Respirat Epith Adenoma

Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 609 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53627

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Minimal

Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma* Prostate Hyperplasia Moderate* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-6 ]* Testes Bilateral, Interstit Cell Adenoma

Tunic Hyperplasia Minimal[ Adenoma TGLs = 1-9 ]

* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 610 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53628

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate

Coagulating Gland Hyperplasia Moderate* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalBile Duct Hyperplasia Minimal

Inflammation Chronic, Moderate[ Clear Cell Focus TGLs = 3-6 ]

* Lung Alveolar/Bronchiolar Adenoma[ Alveolar/Bronchiolar Adenoma TGLs = 1-5 ]

* Lymph Node, Mediastinal Hyperplasia Lymphoid, Moderate[ Hyperplasia TGLs = 4-3 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Marked

Inflammation Chronic Active, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 262

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ANIMAL ID: 610 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53628

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Marked* Pituitary Gland Pars Distalis Adenoma* Testes Interstit Cell Adenoma

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 611 TRT#: 7 SEX: Male DAY ON TEST: 449DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53629

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Mammary Gland * Pancreas * Parathyroid Gland * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-1 ]* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Larynx Leukemia Mononuclear* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-6 ]* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-4+5 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-7 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 611 TRT#: 7 SEX: Male DAY ON TEST: 449DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53629

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, ModerateLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Moderate* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-15 ]* Testes Interstit Cell Adenoma

Tunic Hyperplasia Minimal* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 612 TRT#: 7 SEX: Male DAY ON TEST: 542DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53630

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Esophagus * Eye * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Parathyroid Gland * Pituitary Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Stomach, Glandular * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

INSUFFICIENT TISSUE* Thymus

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-1 ]* Epididymis Mesothelioma Malignant* Harderian Gland Leukemia Mononuclear* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-6 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-4+5 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 612 TRT#: 7 SEX: Male DAY ON TEST: 542DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53630

ORGAN AND ACCOUNTABLE SITE STATUS

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, ModerateThrombosis Mild

* Pancreas Atrophy Mild* Prostate Inflammation Suppurative, Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-14 ]* Stomach, Forestomach Ulcer Moderate* Testes Interstit Cell Hyperplasia Minimal

Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 613 TRT#: 7 SEX: Male DAY ON TEST: 726DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53631

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Rectum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Parathyroid Gland * Preputial Gland * Salivary Glands* Skin * Thymus * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Thrombosis Moderate

[ Thrombosis TGLs = 10-6 ]* Intestine Large, Cecum Mesothelioma Malignant* Intestine Large, Colon Mesothelioma Malignant* Intestine Small, Duodenum Mesothelioma Malignant* Intestine Small, Ileum Mesothelioma Malignant* Kidney Nephropathy Mild* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-17 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 9-3 ]* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2,8-14+17 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Marked

Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 613 TRT#: 7 SEX: Male DAY ON TEST: 726DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53631

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

Thrombosis Mild* Pancreas Mesothelioma Malignant* Pituitary Gland Pars Distalis Hyperplasia Mild* Prostate Mesothelioma Malignant* Seminal Vesicle Mesothelioma Malignant

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 3-15 ]

* Spleen Leukemia Mononuclear* Stomach, Forestomach Mesothelioma Malignant

Ulcer Moderate* Stomach, Glandular Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 7-9 ][ Mesothelioma Malignant TGLs = 6-16 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Spleen Leukemia MononuclearAnimal Note: TGL 5 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 614 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53632

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Spleen * Stomach, Forestomach* Stomach, Glandular * Testes * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalBile Duct Hyperplasia Minimal

Inflammation Chronic, Mild[ Clear Cell Focus TGLs = 4-6 ]

* Lung Alveolar/Bronchiolar Carcinoma[ Alveolar/Bronchiolar Carcinoma TGLs = 2-16 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 614 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53632

ORGAN AND ACCOUNTABLE SITE STATUS

* Skin Basal Cell Adenoma[ Basal Cell Adenoma TGLs = 1-14 ]

* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 615 TRT#: 7 SEX: Male DAY ON TEST: 670DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53633

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Testes* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Clear Cell Focus

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, Mild

[ Clear Cell Focus TGLs = 3-6 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15+16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MarkedRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Parathyroid Gland Hyperplasia Mild* Pituitary Gland Pars Distalis Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 616 TRT#: 7 SEX: Male DAY ON TEST: 10DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53634

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Kidney * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Pancreas * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Testes * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Epididymis Degeneration Mild* Liver Inflammation Chronic, Minimal* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MinimalInflammation Chronic Active, Minimal

Pleura Hyperplasia MildInfiltration Cellular Mononuclear Cl, Moderate

PRIMARY CAUSE OF DEATH - Pleura Infiltration Cellular

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 617 TRT#: 7 SEX: Male DAY ON TEST: 718DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53635

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Lung * Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Testes* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Islets, Pancreatic Carcinoma

Hyperplasia Mild[ Carcinoma TGLs = 1-14 ]

* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Fatty Change Diffuse, ModerateInflammation Chronic, Minimal

[ Fatty Change TGLs = 3-6 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Carcinoma[ Carcinoma TGLs = 2-15 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 5-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 617 TRT#: 7 SEX: Male DAY ON TEST: 718DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53635

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 618 TRT#: 7 SEX: Male DAY ON TEST: 676DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53636

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Larynx * Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Minimal* Islets, Pancreatic Carcinoma* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Bile Duct Hyperplasia Moderate

Inflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia MononuclearMesentery Fat Necrosis Mild

[ Necrosis TGLs = 2-16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

Thrombosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 618 TRT#: 7 SEX: Male DAY ON TEST: 676DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53636

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-15 ]* Stomach, Forestomach Ulcer Moderate* Testes Interstit Cell Hyperplasia Minimal

Tongue Hyperplasia Squamous, Moderate[ Hyperplasia TGLs = 1-14 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 619 TRT#: 7 SEX: Male DAY ON TEST: 534DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53637

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Jejunum * Islets, Pancreatic * Pancreas* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Moderate* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 7-14 ]* Heart Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Larynx Inflammation Chronic Active, Moderate* Liver Degeneration Cystic, Mild

Inflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-4+5 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, MarkedThrombosis Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 619 TRT#: 7 SEX: Male DAY ON TEST: 534DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53637

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-15 ]

* Stomach, Forestomach Ulcer Marked[ Ulcer TGLs = 5,8-10+15 ]

* Testes Interstit Cell Adenoma[ Adenoma TGLs = 3-9 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 620 TRT#: 7 SEX: Male DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53638

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate

Pheochromocytoma Malignant* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Basophilic Focus

CholangiocarcinomaClear Cell FocusDegeneration Cystic, MarkedFatty Change Diffuse, MinimalHepatodiaphragmatic NoduleInflammation Chronic, MinimalLeukemia MononuclearMixed Cell Focus

[ Clear Cell Focus TGLs = 5-6+18 ][ Hepatodiaphragmatic Nodule TGLs = 7-6 ][ Mixed Cell Focus TGLs = 5-18 ]

* Lung Alveolar Epith Hyperplasia ModerateLeukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 620 TRT#: 7 SEX: Male DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53638

ORGAN AND ACCOUNTABLE SITE STATUS

[ Hyperplasia TGLs = 9-5 ]* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-18 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 8-10 ]

* Prostate Hyperplasia Mild* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 2-14+15+16 ]* Spleen Leukemia Mononuclear* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 621 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53639

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Clear Cell Focus

Degeneration Cystic, MinimalInflammation Chronic, Mild

Mesentery Mesothelioma MalignantFat Necrosis Mild

[ Necrosis TGLs = 1-15 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, ModerateOlfactory Epi Metaplasia Squamous, Minimal

* Pancreas Hyperplasia Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 621 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53639

ORGAN AND ACCOUNTABLE SITE STATUS

* Testes Mesothelioma Malignant* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 622 TRT#: 7 SEX: Male DAY ON TEST: 600DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53640

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Forestomach* Stomach, Glandular * Testes * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Minimal* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Harderian Gland Leukemia Mononuclear* Heart Cardiomyopathy Minimal

Leukemia MononuclearThrombosis Mild

[ Cardiomyopathy TGLs = 8-14 ]* Kidney Infarct Mild

Leukemia MononuclearNephropathy Mild

[ Infarct TGLs = 9,10-16+7 ]* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-6 ]* Lung Leukemia Mononuclear

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-15 ]

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 622 TRT#: 7 SEX: Male DAY ON TEST: 600DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53640

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, MarkedLeukemia Mononuclear

Respirat Epith Metaplasia Squamous, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Spleen Leukemia Mononuclear

Necrosis Mild[ Leukemia Mononuclear TGLs = 4,5-15 ][ Necrosis TGLs = 7-15 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 623 TRT#: 7 SEX: Male DAY ON TEST: 561DOSE: 100 ppm DISP: Natural Death HISTO: 53641

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland* Pituitary Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Thymus * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

AUTO PRECLUDES DIAG.* Intestine Large, Cecum

OBSERVATIONS* Epididymis Mesothelioma Malignant* Kidney Mesothelioma Malignant

Nephropathy Mild* Liver Inflammation Chronic, Mild

Necrosis ModerateMesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 3-16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MarkedInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, ModerateThrombosis Marked

* Pancreas Atrophy MinimalMesothelioma Malignant

Peritoneum Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 6-15 ]

Skeletal Muscle Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 623 TRT#: 7 SEX: Male DAY ON TEST: 561DOSE: 100 ppm DISP: Natural Death HISTO: 53641

ORGAN AND ACCOUNTABLE SITE STATUS

[ Mesothelioma Malignant TGLs = 7-14 ]* Spleen Fibrosis Moderate

Mesothelioma Malignant[ Fibrosis TGLs = 2-6 ]

* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant

Ulcer Moderate* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 4-9 ][ Mesothelioma Malignant TGLs = 5-17 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma MalignantAnimal Note: TGL 8 - NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 624 TRT#: 7 SEX: Male DAY ON TEST: 619DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53642

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Epididymis * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Parathyroid Gland * Preputial Gland * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Testes * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Mild* Liver Fatty Change Diffuse, Moderate

Hepatodiaphragmatic NoduleInflammation Chronic, Mild

[ Hepatodiaphragmatic Nodule TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Moderate

[ Hyperplasia TGLs = 1-5 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Prostate Inflammation Suppurative, Moderate

[ Inflammation TGLs = 4-14 ]* Thyroid Gland C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 625 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53643

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Larynx * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild

Leukemia Mononuclear* Islets, Pancreatic Hyperplasia Moderate* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Bile Duct Hyperplasia Mild

Inflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-4+5 ]* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-14 ]* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 625 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53643

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Angiectasis Mild

Pars Distalis Hyperplasia Mild[ Angiectasis TGLs = 2-10 ]

* Spleen Fibrosis MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-15 ]* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 6-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 626 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53644

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Degeneration Cystic, MinimalFatty Change Diffuse, Mild

Bile Duct Hyperplasia MinimalInflammation Chronic, ModerateMixed Cell Focus

[ Clear Cell Focus TGLs = 3-17+18 ][ Mixed Cell Focus TGLs = 3-18 ]

* Lung Alveolar Epith Hyperplasia Moderate* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedRespirat Epith Metaplasia Squamous, MildOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 626 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53644

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Prostate Hyperplasia Mild* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 1-14+15 ]* Testes Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 627 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53645

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland * Preputial Gland* Prostate * Salivary Glands * Seminal Vesicle * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Benign* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Degeneration Cystic, MinimalFatty Change Diffuse, MildInflammation Chronic, Mild

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy Mild* Pituitary Gland Pars Distalis Adenoma* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 627 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53645

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 628 TRT#: 7 SEX: Male DAY ON TEST: 628DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53646

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Preputial Gland* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Testes * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Moderate

Pheochromocytoma BenignCoagulating Gland Hyperplasia Moderate

* Heart Cardiomyopathy Mild* Kidney Transit Epithe Hyperplasia Minimal

Nephropathy Marked[ Nephropathy TGLs = 2-7 ]

* Liver Fatty Change Diffuse, ModerateInflammation Chronic, Minimal

[ Fatty Change TGLs = 1-6 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Prostate Inflammation Suppurative, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 295

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ANIMAL ID: 628 TRT#: 7 SEX: Male DAY ON TEST: 628DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53646

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Transit Epithe Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 629 TRT#: 7 SEX: Male DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53647

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Pituitary Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild

[ Nephropathy TGLs = 4-7 ]* Liver Inflammation Chronic, Mild* Lung Alveolar Epith Hyperplasia Mild

[ Hyperplasia TGLs = 3-4 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Moderate

* Skin Keratoacanthoma[ Keratoacanthoma TGLs = 1,6-15+14 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 5-9 ]

* Thyroid Gland C Cell Carcinoma[ Carcinoma TGLs = 2-3 ]

PRIMARY CAUSE OF DEATH - UNCERTAIN

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 630 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53648

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Stomach, Glandular * Testes* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Moderate

Pheochromocytoma Benign* Eye Cornea Inflammation Chronic Active, Minimal* Heart Cardiomyopathy Moderate* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Degeneration Cystic, Mild

Eosinophilic FocusFatty Change Diffuse, MinimalHepatodiaphragmatic Nodule

Bile Duct Hyperplasia MinimalInflammation Chronic, ModerateLeukemia Mononuclear

[ Hepatodiaphragmatic Nodule TGLs = 6-14 ][ Leukemia Mononuclear TGLs = 5-6 ]

* Lung Leukemia MononuclearMetaplasia Osseous, Mild

[ Metaplasia TGLs = 4-4+5 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 298

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ANIMAL ID: 630 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53648

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Respirat Epith Adenoma

Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 7-10 ]* Spleen Fibrosis Moderate

Leukemia Mononuclear[ Fibrosis TGLs = 3-6 ]

* Thyroid Gland C Cell Hyperplasia MinimalTongue Hyperplasia Squamous, Mild

[ Hyperplasia TGLs = 1-7 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 631 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53649

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Pancreas * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Inflammation Chronic, Moderate

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Foreign BodyTurbinate Hyperostosis MarkedRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked* Pituitary Gland Pars Distalis Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 300

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ANIMAL ID: 631 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53649

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-6 ]

* Testes Bilateral, Interstit Cell Adenoma[ Adenoma TGLs = 1-9 ]

* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 301

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ANIMAL ID: 632 TRT#: 7 SEX: Male DAY ON TEST: 694DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53650

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Larynx * Lymph Node, Bronchial * Lymph Node, Mesenteric * Parathyroid Gland* Preputial Gland * Salivary Glands * Seminal Vesicle * Skin* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild

Coagulating Gland Inflammation Suppurative, Moderate* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Thrombosis Mild* Islets, Pancreatic Hyperplasia Mild* Kidney Inflammation Suppurative, Moderate

Nephropathy Mild* Liver Degeneration Cystic, Mild

Fatty Change Diffuse, MildInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia MinimalOsteosarcoma Metastatic (Uncertain Primary Site)

[ Osteosarcoma TGLs = 3-4+5 ]Mesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 8-19 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 302

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ANIMAL ID: 632 TRT#: 7 SEX: Male DAY ON TEST: 694DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53650

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Marked* Pancreas Atrophy Moderate

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2-20 ]

Peritoneum Osteosarcoma Metastatic (Uncertain Primary Site)[ Osteosarcoma TGLs = 4-14+15+16 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 10-10 ]

* Prostate Inflammation Suppurative, MarkedSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 7-18 ]* Spleen Mesothelioma Malignant* Testes Interstit Cell Adenoma

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 5,6-17+9 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Transit Epithe Hyperplasia Mild

Inflammation Acute, Mild[ Inflammation TGLs = 9-22 ]

PRIMARY CAUSE OF DEATH - Peritoneum Osteosarcoma Uncertain Primary Site

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 633 TRT#: 7 SEX: Male DAY ON TEST: 437DOSE: 100 ppm DISP: Natural Death HISTO: 53651

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Rectum* Intestine Small, Duodenum * Islets, Pancreatic * Larynx * Parathyroid Gland* Preputial Gland * Salivary Glands * Seminal Vesicle * Skin* Stomach, Glandular * Testes * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Ileum * Intestine Small, Jejunum* Thyroid Gland * Trachea

OBSERVATIONS* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-1 ]* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, ModerateLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, ModerateThrombosis Moderate

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 633 TRT#: 7 SEX: Male DAY ON TEST: 437DOSE: 100 ppm DISP: Natural Death HISTO: 53651

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 2-10 ]* Prostate Inflammation Suppurative, Moderate* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4,7-15 ]* Stomach, Forestomach Ulcer Marked

[ Ulcer TGLs = 6-10 ]* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 634 TRT#: 7 SEX: Male DAY ON TEST: 583DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53652

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Epididymis * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Mammary Gland * Pancreas * Parathyroid Gland * Pituitary Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Stomach, Forestomach * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 7-14 ]* Heart Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Leukemia Mononuclear* Lung Leukemia Mononuclear

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-17 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 9-8 ]

* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 634 TRT#: 7 SEX: Male DAY ON TEST: 583DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53652

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3,4,5-16 ]* Stomach, Glandular Leukemia Mononuclear* Testes Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 635 TRT#: 7 SEX: Male DAY ON TEST: 701DOSE: 100 ppm DISP: Natural Death HISTO: 53653

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Esophagus * Eye * Harderian Gland* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Islets, Pancreatic* Larynx * Mammary Gland * Pancreas * Preputial Gland* Prostate * Skin * Stomach, Forestomach * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Small, Ileum * Intestine Small, Jejunum * Seminal Vesicle

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Bone Osteosarcoma

[ Osteosarcoma TGLs = 9-14 ]* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Leukemia Mononuclear* Lung Leukemia Mononuclear

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 10-15 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-3 ]

* Lymph Node, Mesenteric Leukemia MononuclearMesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 6-19 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 635 TRT#: 7 SEX: Male DAY ON TEST: 701DOSE: 100 ppm DISP: Natural Death HISTO: 53653

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Parathyroid Gland Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma* Salivary Glands Leukemia Mononuclear

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 4-17 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-15 ]

* Stomach, Glandular Leukemia MononuclearNecrosis Minimal

[ Necrosis TGLs = 11-10 ]* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 7,8-16+9 ][ Mesothelioma Malignant TGLs = 5-18 ]

* Thymus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 636 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53654

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Pancreas * Parathyroid Gland* Pituitary Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Marked* Epididymis Mesothelioma Malignant* Kidney Nephropathy Marked

[ Nephropathy TGLs = 5-7 ]* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 4-6 ]* Nose Turbinate Atrophy Marked

Foreign BodyTurbinate Hyperostosis MarkedRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Skin Subcut Tiss FibrosarcomaSubcut Tiss Lipoma

Squamous Cell Papilloma[ Fibrosarcoma TGLs = 2-16+17+18 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 636 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53654

ORGAN AND ACCOUNTABLE SITE STATUS

[ Lipoma TGLs = 6-20 ][ Squamous Cell Papilloma TGLs = 1-14 ]

* Testes Bilateral, Interstit Cell AdenomaMesothelioma Malignant

[ Adenoma TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 637 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53655

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Preputial Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 2-6 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis MarkedRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Hyperplasia Moderate* Prostate Adenoma* Seminal Vesicle Adenoma* Testes Bilateral, Interstit Cell Adenoma

[ Adenoma TGLs = 1-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 312

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ANIMAL ID: 638 TRT#: 7 SEX: Male DAY ON TEST: 593DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53656

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Bronchial * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland * Salivary Glands* Skin * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Epididymis Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 9-9 ]* Heart Thrombosis Mild* Kidney Nephropathy Mild* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, MildMesothelioma Malignant

[ Inflammation TGLs = 4-6+14 ][ Mesothelioma Malignant TGLs = 5-14 ]

* Lung Alveolar/Bronchiolar AdenomaMesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 10-15 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MarkedInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 6-14 ]* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 313

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ANIMAL ID: 638 TRT#: 7 SEX: Male DAY ON TEST: 593DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53656

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Hyperplasia MinimalMesothelioma Malignant

* Seminal Vesicle Mesothelioma MalignantSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 3-16 ]* Spleen Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant* Testes Interstit Cell Adenoma

Atrophy ModerateMesothelioma Malignant

[ Adenoma TGLs = 8-9 ][ Mesothelioma Malignant TGLs = 7-17 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 314

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ANIMAL ID: 639 TRT#: 7 SEX: Male DAY ON TEST: 534DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53657

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Pancreas * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Epididymis Mesothelioma Malignant* Esophagus Hyperplasia Squamous, Moderate* Kidney Transit Epithe Hyperplasia Mild

Nephropathy Minimal* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, Mild[ Fatty Change TGLs = 1-7 ]

* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Mesenteric Inflammation Granulomatous, Moderate

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 315

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ANIMAL ID: 639 TRT#: 7 SEX: Male DAY ON TEST: 534DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53657

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Inflammation Suppurative, Mild* Testes Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 316

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ANIMAL ID: 640 TRT#: 7 SEX: Male DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53658

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Parathyroid Gland * Preputial Gland * Prostate * Salivary Glands* Seminal Vesicle * Skin * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

INSUFFICIENT TISSUE* Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Moderate

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Leukemia Mononuclear

Thrombosis Mild[ Thrombosis TGLs = 4-6 ]

* Kidney Infarct MildLeukemia MononuclearNephropathy Mild

[ Infarct TGLs = 13-21 ]* Liver Degeneration Cystic, Moderate

Hepatodiaphragmatic NoduleBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 317

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ANIMAL ID: 640 TRT#: 7 SEX: Male DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53658

ORGAN AND ACCOUNTABLE SITE STATUS

Leukemia Mononuclear[ Hepatodiaphragmatic Nodule TGLs = 12-20 ][ Leukemia Mononuclear TGLs = 11-6+20 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 15-20 ]* Lymph Node, Mediastinal Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-3 ]* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 16-8 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]Mesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 8-16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, MarkedOlfactory Epi Metaplasia Squamous, Minimal

* Pancreas Atrophy Mild* Pituitary Gland Angiectasis Mild

Pars Distalis Hyperplasia Mild[ Hyperplasia TGLs = 14-10 ]

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 10-18 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 9-19 ]

* Stomach, Forestomach Leukemia Mononuclear* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 318

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ANIMAL ID: 640 TRT#: 7 SEX: Male DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53658

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 5,6-9 ][ Mesothelioma Malignant TGLs = 7-17 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 641 TRT#: 7 SEX: Male DAY ON TEST: 535DOSE: 100 ppm DISP: Natural Death HISTO: 53659

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Brain* Epididymis * Esophagus * Kidney * Lung* Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland * Salivary Glands* Spleen * Stomach, Forestomach * Testes * Thymus* Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

AUTO PRECLUDES DIAG.* Bone Marrow * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Pancreas* Seminal Vesicle * Thyroid Gland * Trachea

OBSERVATIONS* Heart Cardiomyopathy Mild

Thrombosis Moderate* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, MinimalNecrosis Moderate

* Lymph Node, Bronchial Infiltration Cellular Histiocyte, Moderate[ Infiltration Cellular TGLs = 2-7 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Thrombosis Marked* Pituitary Gland Pars Distalis Hyperplasia Mild

[ Hyperplasia TGLs = 3-10 ]* Prostate Inflammation Suppurative, Moderate* Skin Keratoacanthoma

[ Keratoacanthoma TGLs = 1-14 ]* Stomach, Glandular Necrosis Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 641 TRT#: 7 SEX: Male DAY ON TEST: 535DOSE: 100 ppm DISP: Natural Death HISTO: 53659

ORGAN AND ACCOUNTABLE SITE STATUS

[ Necrosis TGLs = 4-10 ]

PRIMARY CAUSE OF DEATH - Heart Thrombosis

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 642 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53660

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Epididymis* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Pancreas * Parathyroid Gland* Preputial Gland * Prostate * Salivary Glands * Seminal Vesicle* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Testes * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Renal Tubule Carcinoma

Nephropathy Marked[ Carcinoma TGLs = 1-14 ]

* Liver Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, ModerateMixed Cell FocusNecrosis Minimal

[ Clear Cell Focus TGLs = 3-6 ][ Mixed Cell Focus TGLs = 2-7 ]

* Lung Alveolar/Bronchiolar AdenomaAlveolar Epith Hyperplasia Mild

[ Alveolar/Bronchiolar Adenoma TGLs = 7-5 ][ Hyperplasia TGLs = 5-16 ]

* Nose Turbinate Atrophy MarkedForeign Body

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 642 TRT#: 7 SEX: Male DAY ON TEST: 729DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53660

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 643 TRT#: 7 SEX: Male DAY ON TEST: 583DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53661

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Stomach, Glandular* Thymus * Thyroid Gland * Trachea

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Minimal

Thrombosis Moderate[ Thrombosis TGLs = 2-6 ]

* Intestine Large, Colon Adenoma[ Adenoma TGLs = 13-8 ]

* Kidney Renal Tubule Hyperplasia MarkedNephropathy Minimal

* Liver Fatty Change Diffuse, MinimalInflammation Chronic, MinimalLeukemia MononuclearMesothelioma Malignant

[ Leukemia Mononuclear TGLs = 7-6 ][ Mesothelioma Malignant TGLs = 8,12-6 ]

* Lung Alveolar Epith Hyperplasia ModerateLeukemia Mononuclear

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 643 TRT#: 7 SEX: Male DAY ON TEST: 583DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53661

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mesenteric Leukemia MononuclearMesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 6-17 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 10-15 ]

* Pituitary Gland Pars Distalis Hyperplasia ModerateSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 11-18 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 9-14 ]* Stomach, Forestomach Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 4,5-9+16 ]

* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Epididymis Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 644 TRT#: 7 SEX: Male DAY ON TEST: 653DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53662

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Parathyroid Gland * Pituitary Gland * Preputial Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Mammary Gland

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Benign* Epididymis Mesothelioma Malignant* Kidney Nephropathy Mild* Liver Degeneration Cystic, Mild

Bile Duct Hyperplasia MinimalInflammation Chronic, ModerateNecrosis Moderate

[ Necrosis TGLs = 8,9-6+14 ]* Lung Alveolar Epith Hyperplasia Mild

Mesentery Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 10-17 ]

* Nose Turbinate Atrophy MarkedForeign Body

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, MarkedOlfactory Epi Metaplasia Squamous, Minimal

* Pancreas Atrophy Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 644 TRT#: 7 SEX: Male DAY ON TEST: 653DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53662

ORGAN AND ACCOUNTABLE SITE STATUS

* Prostate Mesothelioma Malignant* Seminal Vesicle Mesothelioma Malignant

Skeletal Muscle Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 2-15 ]

* Spleen Hyperplasia Lymphoid, Mild[ Hyperplasia TGLs = 6-6 ]

* Testes Bilateral, Interstit Cell AdenomaMesothelioma Malignant

[ Adenoma TGLs = 4-9 ][ Mesothelioma Malignant TGLs = 5-16 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Testes Mesothelioma MalignantAnimal Note: TGL 3 = NCLAnimal Note: TGL 7 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 327

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ANIMAL ID: 645 TRT#: 7 SEX: Male DAY ON TEST: 607DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53663

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Epididymis * Esophagus* Eye * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Parathyroid Gland * Preputial Gland * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Stomach, Glandular* Testes * Thyroid Gland * Trachea

MISSING* Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Harderian Gland Degeneration Moderate* Heart Leukemia Mononuclear* Kidney Inflammation Suppurative, Mild

Leukemia MononuclearMesenchymal Tumor Malignant

[ Mesenchymal Tumor Malignant TGLs = 7-7 ]* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, MildLeukemia Mononuclear

[ Inflammation TGLs = 5-6 ][ Leukemia Mononuclear TGLs = 6-6 ]

* Lung Carcinoma Metastatic (Kidney)Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-4+5 ]Lymph Node Deep Cervical Leukemia Mononuclear

Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 328

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ANIMAL ID: 645 TRT#: 7 SEX: Male DAY ON TEST: 607DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53663

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 13,14-19 ]* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-14 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 15,16-18 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, MarkedOlfactory Epi Metaplasia Squamous, Mild

* Pancreas Atrophy MinimalLeukemia Mononuclear

* Pituitary Gland Pars Distalis AdenomaLeukemia Mononuclear

[ Adenoma TGLs = 11-10 ]* Prostate Inflammation Suppurative, Marked

[ Inflammation TGLs = 12-10 ]* Spleen Leukemia Mononuclear

Necrosis Moderate[ Leukemia Mononuclear TGLs = 4,8,9-16+17 ][ Necrosis TGLs = 10-17 ]

* Thymus Leukemia Mononuclear* Urinary Bladder Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 646 TRT#: 7 SEX: Male DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53664

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Pancreas * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Skin * Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland * Thymus

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Moderate

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Epididymis Mesothelioma Malignant* Heart Leukemia Mononuclear* Islets, Pancreatic Carcinoma* Kidney Leukemia Mononuclear

Nephropathy Moderate[ Nephropathy TGLs = 8-7 ]

* Liver Bile Duct Hyperplasia MinimalInflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 7-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear[ Hyperplasia TGLs = 11-16 ]

Lymph Node Deep Cervical Leukemia MononuclearPancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-16 ][ Leukemia Mononuclear TGLs = 12-17 ]

* Lymph Node, Mediastinal Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 646 TRT#: 7 SEX: Male DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53664

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mesenteric Leukemia MononuclearMesentery Mesothelioma Malignant

Fat Necrosis Mild[ Necrosis TGLs = 9-19 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Marked

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, MarkedOlfactory Epi Metaplasia Squamous, Minimal

* Pituitary Gland Pars Distalis AdenomaLeukemia Mononuclear

* Seminal Vesicle Mesothelioma MalignantSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 10-15 ]* Spleen Leukemia Mononuclear

Mesothelioma Malignant[ Leukemia Mononuclear TGLs = 3,4-17 ][ Mesothelioma Malignant TGLs = 5-17 ]

* Stomach, Forestomach Ulcer Moderate* Stomach, Glandular Necrosis Mild

[ Necrosis TGLs = 13-18 ]* Testes Atrophy Moderate

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 6-14 ]

* Urinary Bladder Mesothelioma Malignant

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 647 TRT#: 7 SEX: Male DAY ON TEST: 619DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53665

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Preputial Gland* Prostate * Salivary Glands * Skin * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Parathyroid Gland

OBSERVATIONS* Epididymis Mesothelioma Malignant* Heart Cardiomyopathy Mild

Thrombosis Marked[ Thrombosis TGLs = 8-6 ]

* Kidney Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Inflammation Acute, MildNecrosis Mild

[ Necrosis TGLs = 6-6 ]Mesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 7-16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Mesothelioma Malignant* Pituitary Gland Pars Distalis Hyperplasia Minimal* Seminal Vesicle Mesothelioma Malignant

Skeletal Muscle Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 647 TRT#: 7 SEX: Male DAY ON TEST: 619DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53665

ORGAN AND ACCOUNTABLE SITE STATUS

[ Mesothelioma Malignant TGLs = 3-14 ]* Spleen Mesothelioma Malignant* Stomach, Forestomach Mesothelioma Malignant* Stomach, Glandular Mesothelioma Malignant* Testes Bilateral, Interstit Cell Adenoma

Mesothelioma Malignant[ Adenoma TGLs = 5-9 ][ Mesothelioma Malignant TGLs = 4-15 ]

PRIMARY CAUSE OF DEATH - Heart Thrombosis

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 333

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ANIMAL ID: 648 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53666

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Harderian Gland* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Salivary Glands* Seminal Vesicle * Skin * Stomach, Forestomach * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Epididymis Leukemia Mononuclear* Eye Degeneration Marked

[ Degeneration TGLs = 6-13 ]* Heart Cardiomyopathy Mild* Intestine Large, Cecum Leukemia Mononuclear* Intestine Large, Colon Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Bile Duct Hyperplasia Mild

Inflammation Chronic, ModerateLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Alveolar Epith Hyperplasia Marked

Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 334

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ANIMAL ID: 648 TRT#: 7 SEX: Male DAY ON TEST: 730DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53666

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 8-7 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Mild

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Respirat Epith Metaplasia Squamous, MildOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 7-10 ]

* Preputial Gland Leukemia Mononuclear* Prostate Hyperplasia Mild

Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3,4-14+6 ]* Stomach, Glandular Leukemia Mononuclear* Testes Interstit Cell Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 2-9 ]

* Thymus Leukemia MononuclearTissue NOS Abdominal Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 9-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 335

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ANIMAL ID: 649 TRT#: 7 SEX: Male DAY ON TEST: 617DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53667

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Spleen * Stomach, Forestomach* Stomach, Glandular * Testes * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Mammary Gland

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Eye Retina Atrophy Marked

Cataract Marked[ Cataract TGLs = 2-13 ]

* Heart Cardiomyopathy MinimalFibrous Histiocytoma Metastatic (Skin)

* Kidney Nephropathy Mild* Liver Clear Cell Focus

Degeneration Cystic, ModerateInflammation Chronic, MinimalMixed Cell Focus

[ Mixed Cell Focus TGLs = 4-14 ]* Lung Fibrous Histiocytoma Metastatic (Skin)

Alveolar Epith Hyperplasia Mild[ Fibrous Histiocytoma TGLs = 3-4+5 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 649 TRT#: 7 SEX: Male DAY ON TEST: 617DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53667

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma* Skin Subcut Tiss Fibrous Histiocytoma

[ Fibrous Histiocytoma TGLs = 1-15 ]

PRIMARY CAUSE OF DEATH - Skin Subcut Tiss Fibrous Histiocytoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 650 TRT#: 7 SEX: Male DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53668

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Epididymis * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Lymph Node, Mesenteric* Mammary Gland * Parathyroid Gland * Preputial Gland * Prostate* Salivary Glands * Seminal Vesicle * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Islets, Pancreatic Adenoma

[ Adenoma TGLs = 3-6 ]* Kidney Nephropathy Moderate* Liver Basophilic Focus

Fatty Change Diffuse, ModerateInflammation Chronic, Moderate

[ Basophilic Focus TGLs = 2-6 ]* Lung Alveolar Epith Hyperplasia Mild* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Atrophy Mild

Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Testes Interstit Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 101 TRT#: 2 SEX: Female DAY ON TEST: 732DOSE: Control DISP: Terminal Sacrifice HISTO: 53569

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Nose * Pancreas * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia MildHypertrophy Mild

* Adrenal Medulla Hyperplasia Mild* Harderian Gland Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusHepatodiaphragmatic Nodule

[ Hepatodiaphragmatic Nodule TGLs = 5-6 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 6-9 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]* Ovary Granulosa-Theca Tumor Malignant

[ Granulosa-Theca Tumor Malignant TGLs = 3-9 ]* Pituitary Gland Pars Distalis Hyperplasia Mild* Uterus Bilateral Polyp Stromal

[ Polyp Stromal TGLs = 1,2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 102 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53570

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate

Hypertrophy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2,3-17+16+18 ]* Pituitary Gland Pars Distalis Angiectasis Minimal

Pars Distalis Hyperplasia Mild[ Angiectasis TGLs = 5-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 4-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 103 TRT#: 2 SEX: Female DAY ON TEST: 551DOSE: Control DISP: Moribund Sacrifice HISTO: 53571

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Bronchial * Lymph Node, Mesenteric * Mammary Gland* Nose * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Eosinophilic FocusInflammation Chronic, Minimal

* Lung Inflammation Chronic Active, MinimalAlveolar Epith Metaplasia Squamous, Minimal

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-16 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Skin Keratoacanthoma[ Keratoacanthoma TGLs = 1,2-14 ]

* Thyroid Gland C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 104 TRT#: 2 SEX: Female DAY ON TEST: 724DOSE: Control DISP: Moribund Sacrifice HISTO: 53572

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Glandular * Thymus* Thyroid Gland * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Eye Cornea Inflammation Chronic Active, Mild* Heart Cardiomyopathy Minimal* Kidney Hydronephrosis Mild

Leukemia Mononuclear* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 6-18 ]* Nose Inflammation Acute, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 104 TRT#: 2 SEX: Female DAY ON TEST: 724DOSE: Control DISP: Moribund Sacrifice HISTO: 53572

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-16 ]

* Stomach, Forestomach Ulcer Moderate[ Ulcer TGLs = 8-10 ]

* Urinary Bladder Inflammation Chronic Active, Mild[ Inflammation TGLs = 3-17 ]

* Uterus Inflammation Chronic Active, Marked[ Inflammation TGLs = 4-14 ]

PRIMARY CAUSE OF DEATH - Uterus Inflammation

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 105 TRT#: 2 SEX: Female DAY ON TEST: 666DOSE: Control DISP: Moribund Sacrifice HISTO: 53573

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Lung* Lymph Node, Mesenteric * Nose * Ovary * Pancreas* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Carcinoma

Hypertrophy Mild[ Carcinoma TGLs = 5-7 ]

* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Larynx Metaplasia Squamous, Minimal* Liver Angiectasis Minimal

Basophilic FocusInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1-15+16+17 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 6-14 ]

* Parathyroid Gland Hyperplasia Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 106 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53574

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose* Ovary * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Bilateral Adenoma

Hyperplasia Moderate* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-9 ]

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Angiectasis Moderate

Pars Distalis Hyperplasia Mild[ Angiectasis TGLs = 3-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 345

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ANIMAL ID: 107 TRT#: 2 SEX: Female DAY ON TEST: 732DOSE: Control DISP: Terminal Sacrifice HISTO: 53575

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Mammary Gland * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Mixed Cell Focus[ Mixed Cell Focus TGLs = 2,3,5,6,4,7-14+16+6+7+15 ]

* Lymph Node, Mesenteric Hyperplasia Lymphoid, Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Thyroid Gland C Cell Adenoma

C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 108 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53576

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Kidney* Larynx * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Pituitary Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

* Lung Alveolar/Bronchiolar Adenoma[ Alveolar/Bronchiolar Adenoma TGLs = 2-4 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14+15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 109 TRT#: 2 SEX: Female DAY ON TEST: 725DOSE: Control DISP: Moribund Sacrifice HISTO: 53577

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Bronchial * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Nose * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Clitoral Gland * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Marked* Bone Osteosarcoma* Heart Cardiomyopathy Minimal* Kidney Renal Tubule Hyperplasia Mild

Nephropathy Mild* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, MinimalMixed Cell Focus

[ Eosinophilic Focus TGLs = 8-6 ][ Mixed Cell Focus TGLs = 9,10-6+14 ]

* Lung Alveolar Epith Hyperplasia Mild[ Hyperplasia TGLs = 11-4 ]

* Mammary Gland Carcinoma MultipleFibroadenoma Multiple

[ Carcinoma TGLs = 2,7-14+16 ][ Fibroadenoma TGLs = 5,6-17+18+15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 109 TRT#: 2 SEX: Female DAY ON TEST: 725DOSE: Control DISP: Moribund Sacrifice HISTO: 53577

ORGAN AND ACCOUNTABLE SITE STATUS

* Ovary Interstit Cell Hyperplasia Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 110 TRT#: 2 SEX: Female DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53578

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Nose * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2,3,4-16+17+18+19 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 6-7 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 5-10 ]

* Thyroid Gland C Cell AdenomaC Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 350

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ANIMAL ID: 111 TRT#: 2 SEX: Female DAY ON TEST: 698DOSE: Control DISP: Moribund Sacrifice HISTO: 53579

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Nose * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Intestine Large, Rectum * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-6 ]

* Lung Alveolar Epith Hyperplasia Mild[ Hyperplasia TGLs = 3-4 ]

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2-14+15+16+18+19+20 ]

* Pituitary Gland Pars Distalis Hyperplasia Moderate[ Hyperplasia TGLs = 4-10 ]

* Spleen Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 112 TRT#: 2 SEX: Female DAY ON TEST: 724DOSE: Control DISP: Moribund Sacrifice HISTO: 53580

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Brain Carcinoma Metastatic (Pituitary Gland)* Clitoral Gland Adenoma

[ Adenoma TGLs = 4-14 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 3-15 ]

* Pituitary Gland Pars Distalis Carcinoma[ Carcinoma TGLs = 2-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 113 TRT#: 2 SEX: Female DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53581

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Nose * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Carcinoma

Fibroadenoma[ Carcinoma TGLs = 2-23 ][ Fibroadenoma TGLs = 1-22 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 114 TRT#: 2 SEX: Female DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53582

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-23 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 115 TRT#: 2 SEX: Female DAY ON TEST: 732DOSE: Control DISP: Terminal Sacrifice HISTO: 53583

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Nose* Ovary * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Malignant

[ Pheochromocytoma Malignant TGLs = 5-7 ]* Clitoral Gland Carcinoma

[ Carcinoma TGLs = 1-14 ]* Heart Cardiomyopathy Mild* Kidney Nephropathy Moderate* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Lung Pheochromocytoma Malignant Metastatic (Adrenal Medulla)* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 2,3-15+16 ]* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 116 TRT#: 2 SEX: Female DAY ON TEST: 547DOSE: Control DISP: Moribund Sacrifice HISTO: 53584

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Ovary * Pancreas * Parathyroid Gland * Pituitary Gland* Salivary Glands * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Eye Lymphoma Malignant

[ Lymphoma Malignant TGLs = 3-13 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Eosinophilic FocusLymph Node Deep Cervical Lymphoma Malignant

[ Lymphoma Malignant TGLs = 1-14 ]* Lymph Node, Mediastinal Lymphoma Malignant* Lymph Node, Mesenteric Lymphoma Malignant* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 2-15 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-16 ]* Nose Lymphoma Malignant* Skin Subcut Tiss Lymphoma Malignant

[ Lymphoma Malignant TGLs = 5,6-14+11+12+17 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Skin Subcut Tiss Lymphoma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 356

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ANIMAL ID: 117 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53585

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Clitoral Gland Adenoma* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MinimalHepatodiaphragmatic Nodule

[ Hepatodiaphragmatic Nodule TGLs = 5-6 ]* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Carcinoma

Fibroadenoma[ Carcinoma TGLs = 2-15 ][ Fibroadenoma TGLs = 1-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-7 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 357

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ANIMAL ID: 118 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53586

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Nose * Ovary* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2-14+15 ]

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Angiectasis Minimal

Pars Distalis Hyperplasia Mild[ Angiectasis TGLs = 4-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 358

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ANIMAL ID: 119 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53587

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Nose * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Kidney Nephropathy Minimal* Larynx Inflammation Chronic Active, Moderate* Liver Basophilic Focus

Eosinophilic FocusInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2-15+16+14 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 359

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ANIMAL ID: 120 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53588

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Nose * Ovary * Parathyroid Gland * Salivary Glands* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 2-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3,5-16+15 ]

* Pancreas Acinus Atrophy MildBasophilic Focus

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Skin Subcut Tiss Fibroma[ Fibroma TGLs = 1-17 ]

* Thyroid Gland C Cell Hyperplasia Mild* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 6-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 360

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ANIMAL ID: 121 TRT#: 2 SEX: Female DAY ON TEST: 661DOSE: Control DISP: Moribund Sacrifice HISTO: 53589

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Nose * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Blood Vessel Leiomyosarcoma[ Leiomyosarcoma TGLs = 3-14 ]

* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-15+16+17 ]* Ovary Bursa Dilatation Mild

[ Dilatation TGLs = 4-9 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 122 TRT#: 2 SEX: Female DAY ON TEST: 687DOSE: Control DISP: Moribund Sacrifice HISTO: 53590

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Ovary * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

* Lymph Node, Mediastinal Ectasia Moderate[ Ectasia TGLs = 2-18 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-18 ]

* Nose Respirat Epith Hyperplasia MildInflammation Chronic Active, Mild

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Tongue Squamous Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 362

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ANIMAL ID: 122 TRT#: 2 SEX: Female DAY ON TEST: 687DOSE: Control DISP: Moribund Sacrifice HISTO: 53590

ORGAN AND ACCOUNTABLE SITE STATUS

[ Squamous Cell Carcinoma TGLs = 3-16 ]

PRIMARY CAUSE OF DEATH - Tongue Squamous Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 363

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ANIMAL ID: 123 TRT#: 2 SEX: Female DAY ON TEST: 698DOSE: Control DISP: Moribund Sacrifice HISTO: 53591

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Nose* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear* Liver Basophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia Mononuclear* Lymph Node, Mandibular Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-15+16+17+18 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-20 ]* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 123 TRT#: 2 SEX: Female DAY ON TEST: 698DOSE: Control DISP: Moribund Sacrifice HISTO: 53591

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 4-10 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 124 TRT#: 2 SEX: Female DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53592

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-21+22 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 125 TRT#: 2 SEX: Female DAY ON TEST: 592DOSE: Control DISP: Moribund Sacrifice HISTO: 53593

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mesenteric * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Minimal* Lymph Node, Bronchial Congestion Moderate

[ Congestion TGLs = 4-14 ]* Mammary Gland Carcinoma

[ Carcinoma TGLs = 3-15 ]* Nose Inflammation Chronic Active, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Thyroid Gland C Cell Hyperplasia Marked

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 126 TRT#: 2 SEX: Female DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53594

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Mammary Gland * Nose * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-7 ]

* Pituitary Gland Pars Distalis Adenoma* Uterus Polyp Stromal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 127 TRT#: 2 SEX: Female DAY ON TEST: 579DOSE: Control DISP: Natural Death HISTO: 53595

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Nose * Ovary* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

AUTO PRECLUDES DIAG.* Intestine Large, Cecum

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Lymph Node, Mediastinal Hemorrhage Moderate[ Hemorrhage TGLs = 2-3 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-16 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4,5-14+15 ]

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Uterus Polyp Stromal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 128 TRT#: 2 SEX: Female DAY ON TEST: 719DOSE: Control DISP: Moribund Sacrifice HISTO: 53596

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland CarcinomaFibroadenoma

[ Carcinoma TGLs = 4-15 ][ Fibroadenoma TGLs = 3-14 ]

* Nose Foreign BodyRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Minimal

* Ovary Bursa Dilatation Mild[ Dilatation TGLs = 5-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 7-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 370

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ANIMAL ID: 129 TRT#: 2 SEX: Female DAY ON TEST: 656DOSE: Control DISP: Moribund Sacrifice HISTO: 53597

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Rectum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Nose * Parathyroid Gland * Salivary Glands * Skin* Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Intestine Large, Cecum Leukemia Mononuclear* Intestine Large, Colon Leukemia Mononuclear* Intestine Small, Duodenum Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-14 ]* Ovary Bursa Dilatation Minimal

Leukemia Mononuclear[ Dilatation TGLs = 2-9 ]

* Pancreas Leukemia Mononuclear* Pituitary Gland Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-6 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 371

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ANIMAL ID: 129 TRT#: 2 SEX: Female DAY ON TEST: 656DOSE: Control DISP: Moribund Sacrifice HISTO: 53597

ORGAN AND ACCOUNTABLE SITE STATUS

* Stomach, Forestomach Leukemia Mononuclear* Stomach, Glandular Leukemia Mononuclear* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Leukemia Mononuclear* Uterus Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-10 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 372

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ANIMAL ID: 130 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53598

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusBile Duct Hyperplasia Minimal

Inflammation Chronic, Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-7 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 373

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ANIMAL ID: 131 TRT#: 2 SEX: Female DAY ON TEST: 687DOSE: Control DISP: Moribund Sacrifice HISTO: 53599

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 4-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-16 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 374

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ANIMAL ID: 132 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53600

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Bone Marrow Hyperplasia Reticulum Cell, Marked* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, MinimalMixed Cell Focus

[ Mixed Cell Focus TGLs = 2-7 ]* Lung Alveolar Epith Hyperplasia Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Thyroid Gland C Cell Hyperplasia Mild* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 1-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 375

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ANIMAL ID: 133 TRT#: 2 SEX: Female DAY ON TEST: 675DOSE: Control DISP: Moribund Sacrifice HISTO: 53601

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Clitoral Gland* Esophagus * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Parathyroid Gland* Salivary Glands * Skin * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Eye Leukemia Mononuclear* Harderian Gland Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Leukemia Mononuclear

Lymph Node Deep Cervical Leukemia MononuclearPancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-3 ][ Leukemia Mononuclear TGLs = 6-18 ]

* Lymph Node, Mandibular Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-14 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-16 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 9-19 ]

* Nose Respirat Epith Hyperplasia MinimalInflammation Chronic Active, MildLeukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 376

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ANIMAL ID: 133 TRT#: 2 SEX: Female DAY ON TEST: 675DOSE: Control DISP: Moribund Sacrifice HISTO: 53601

ORGAN AND ACCOUNTABLE SITE STATUS

* Ovary Leukemia Mononuclear* Pancreas Acinus Atrophy Minimal

Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Moderate

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7,8-17+20 ]

* Stomach, Forestomach Leukemia MononuclearUlcer Mild

* Stomach, Glandular Leukemia MononuclearNecrosis Mild

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 377

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ANIMAL ID: 134 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53602

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 2-9+14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-7 ]

* Nose Foreign BodyRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, Minimal* Ovary Sertoli Cell Tumor Malignant* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 378

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ANIMAL ID: 135 TRT#: 2 SEX: Female DAY ON TEST: 631DOSE: Control DISP: Moribund Sacrifice HISTO: 53603

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Bronchial * Ovary * Pancreas* Parathyroid Gland * Pituitary Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Harderian Gland Inflammation Chronic, Mild* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Bile Duct Hyperplasia Mild

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma* Nose Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 379

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ANIMAL ID: 135 TRT#: 2 SEX: Female DAY ON TEST: 631DOSE: Control DISP: Moribund Sacrifice HISTO: 53603

ORGAN AND ACCOUNTABLE SITE STATUS

[ Polyp Stromal TGLs = 1-10 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 136 TRT#: 2 SEX: Female DAY ON TEST: 732DOSE: Control DISP: Terminal Sacrifice HISTO: 53604

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Lymph Node, Mesenteric * Mammary Gland * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Larynx Inflammation Chronic Active, Moderate* Liver Basophilic Focus

Fatty Change FocalHepatodiaphragmatic Nodule

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

[ Hepatodiaphragmatic Nodule TGLs = 1-7 ]* Lung Alveolar Epith Hyperplasia Mild* Pituitary Gland Pars Distalis Hyperplasia Moderate* Skin Basal Cell Adenoma

[ Basal Cell Adenoma TGLs = 2-14 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 137 TRT#: 2 SEX: Female DAY ON TEST: 703DOSE: Control DISP: Moribund Sacrifice HISTO: 53605

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Nose * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Hyperplasia Oncocytic, Moderate

Nephropathy Moderate* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, MildMixed Cell Focus

[ Basophilic Focus TGLs = 7-6+16 ][ Mixed Cell Focus TGLs = 7-16 ]

* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Mediastinal Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 6-3 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 3,4,5-17+18+14 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 8-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 137 TRT#: 2 SEX: Female DAY ON TEST: 703DOSE: Control DISP: Moribund Sacrifice HISTO: 53605

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 138 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53606

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Hepatocellular AdenomaInflammation Chronic, Minimal

[ Hepatocellular Adenoma TGLs = 1-7 ]* Lung Alveolar Epith Hyperplasia Mild* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 3-14 ]* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 2-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 139 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53607

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Clitoral Gland* Esophagus * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Nose * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Eye Retina Atrophy Mild

Cataract Mild* Heart Cardiomyopathy Minimal* Kidney Infarct Mild

Leukemia MononuclearNephropathy Minimal

[ Infarct TGLs = 4-7 ]* Liver Basophilic Focus

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-15 ]* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 385

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ANIMAL ID: 139 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53607

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Fibrosis MildLeukemia Mononuclear

[ Fibrosis TGLs = 3-14 ][ Leukemia Mononuclear TGLs = 2-14 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 386

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ANIMAL ID: 140 TRT#: 2 SEX: Female DAY ON TEST: 731DOSE: Control DISP: Terminal Sacrifice HISTO: 53608

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Nose * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Clitoral Gland Adenoma* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Minimal

[ Fatty Change TGLs = 2-6 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-21 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 387

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ANIMAL ID: 141 TRT#: 2 SEX: Female DAY ON TEST: 732DOSE: Control DISP: Terminal Sacrifice HISTO: 53609

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change FocalInflammation Chronic, Minimal

[ Fatty Change TGLs = 6-7 ]* Mammary Gland Fibroadenoma

Hyperplasia Mild[ Fibroadenoma TGLs = 1-14 ][ Hyperplasia TGLs = 2,3-15+16+18 ]

* Pituitary Gland Pars Distalis Hyperplasia Mild[ Hyperplasia TGLs = 5-10 ]

* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 388

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ANIMAL ID: 142 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53610

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 4-7 ]* Mammary Gland Fibroadenoma

Galactocele Mild[ Fibroadenoma TGLs = 1-14 ][ Galactocele TGLs = 2-15 ]

* Nose Inflammation Chronic Active, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Spleen Fibrosis Moderate

[ Fibrosis TGLs = 5-6+16 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 389

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ANIMAL ID: 143 TRT#: 2 SEX: Female DAY ON TEST: 694DOSE: Control DISP: Moribund Sacrifice HISTO: 53611

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Kidney * Larynx * Mammary Gland * Nose* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Bone Sarcoma Metastatic (Uncertain Primary Site)

[ Sarcoma TGLs = 11-19 ]* Liver Basophilic Focus

Fatty Change MildInflammation Chronic, MinimalSarcoma Metastatic (Uncertain Primary Site)

[ Sarcoma TGLs = 9-20 ]* Lung Sarcoma Metastatic (Uncertain Primary Site)

[ Sarcoma TGLs = 3,4,5,6,7,8-5+4 ]* Lymph Node, Mesenteric Congestion Moderate

[ Congestion TGLs = 12-21 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 10-10 ]Skeletal Muscle Sarcoma Metastatic (Uncertain Primary Site)

[ Sarcoma TGLs = 1-14+15 ]* Thymus Sarcoma Metastatic (Uncertain Primary Site)

[ Sarcoma TGLs = 2-17+18 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Lung Sarcoma Uncertain Primary Site

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 144 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53612

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Nose * Ovary * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Mild* Liver Angiectasis Mild

Basophilic FocusClear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

[ Angiectasis TGLs = 3-7 ][ Clear Cell Focus TGLs = 2-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Pancreas Acinus Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 1-14+16 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 391

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ANIMAL ID: 145 TRT#: 2 SEX: Female DAY ON TEST: 732DOSE: Control DISP: Terminal Sacrifice HISTO: 53613

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Mammary Gland * Nose * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 392

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ANIMAL ID: 146 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53614

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Nose * Ovary * Parathyroid Gland* Salivary Glands * Stomach, Forestomach * Stomach, Glandular * Thyroid Gland* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-15 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-7 ]* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Skin Cyst Epithelial Inclusion Moderate

[ Cyst Epithelial Inclusion TGLs = 2-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 393

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ANIMAL ID: 146 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53614

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-6 ]

* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 394

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ANIMAL ID: 147 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53615

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Nose* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Minimal* Pituitary Gland Pars Distalis Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 395

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ANIMAL ID: 148 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53616

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Mammary Gland * Pancreas * Parathyroid Gland * Pituitary Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear

Vacuolization Cytoplasmic Moderate* Adrenal Medulla Leukemia Mononuclear* Clitoral Gland Adenoma

[ Adenoma TGLs = 1-9 ]* Eye Degeneration Marked

[ Degeneration TGLs = 5-13 ]* Harderian Gland Hyperplasia Mild* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Inflammation Chronic Active, Minimal* Ovary Bursa Dilatation Mild

Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 148 TRT#: 2 SEX: Female DAY ON TEST: 733DOSE: Control DISP: Terminal Sacrifice HISTO: 53616

ORGAN AND ACCOUNTABLE SITE STATUS

[ Dilatation TGLs = 2-9 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Moderate* Uterus Endometrium Hyperplasia Cystic, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 397

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ANIMAL ID: 149 TRT#: 2 SEX: Female DAY ON TEST: 732DOSE: Control DISP: Terminal Sacrifice HISTO: 53617

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Nose* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, Minimal

Bile Duct Hyperplasia MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14 ]

* Pituitary Gland Pars Distalis Angiectasis ModeratePars Distalis Hyperplasia Mild

[ Angiectasis TGLs = 2-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 398

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ANIMAL ID: 150 TRT#: 2 SEX: Female DAY ON TEST: 691DOSE: Control DISP: Moribund Sacrifice HISTO: 53618

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Nose* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Basophilic Focus

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15 ]* Ovary Bursa Dilatation Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-17 ]* Stomach, Forestomach Ulcer Minimal* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 399

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ANIMAL ID: 150 TRT#: 2 SEX: Female DAY ON TEST: 691DOSE: Control DISP: Moribund Sacrifice HISTO: 53618

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 400

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ANIMAL ID: 301 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53869

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildHepatodiaphragmatic NoduleInflammation Chronic, Minimal

[ Basophilic Focus TGLs = 5-6 ][ Clear Cell Focus TGLs = 5-6 ][ Hepatodiaphragmatic Nodule TGLs = 2,3-7+14 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Ovary Granulosa Cell Tumor Benign* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 401

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ANIMAL ID: 302 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53870

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Ovary* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Mild* Liver Basophilic Focus

Eosinophilic FocusInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-15+16+17+18 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]* Nose Turbinate Atrophy Mild

Foreign BodyTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Thyroid Gland C Cell Hyperplasia Mild* Uterus Polyp Stromal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 402

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ANIMAL ID: 303 TRT#: 4 SEX: Female DAY ON TEST: 675DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53871

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Kidney Leukemia Mononuclear* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-17 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 403

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ANIMAL ID: 303 TRT#: 4 SEX: Female DAY ON TEST: 675DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53871

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 6-10 ]* Spleen Fibrosis Mild

Hemorrhage MildLeukemia Mononuclear

[ Fibrosis TGLs = 2-15 ][ Hemorrhage TGLs = 3-16 ][ Leukemia Mononuclear TGLs = 4-14 ]

* Stomach, Forestomach Leukemia Mononuclear* Stomach, Glandular Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Mild* Uterus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 404

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ANIMAL ID: 304 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53872

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Minimal* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Angiectasis Minimal

Eosinophilic FocusInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-16+17+18 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 6-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 5-9 ]* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 405

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ANIMAL ID: 304 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53872

ORGAN AND ACCOUNTABLE SITE STATUS

* SkinNote: TGLs 7 and 8 were normal subcutaneous fat.

* Thyroid Gland C Cell Carcinoma[ Carcinoma TGLs = 2-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 406

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ANIMAL ID: 305 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53873

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Ovary * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, MinimalMixed Cell Focus

[ Basophilic Focus TGLs = 4-6 ][ Clear Cell Focus TGLs = 4-6 ][ Mixed Cell Focus TGLs = 4-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14+15 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-16 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 407

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ANIMAL ID: 305 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53873

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Mild* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 408

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ANIMAL ID: 306 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53874

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Clitoral Gland Adenoma

[ Adenoma TGLs = 1-14 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusInflammation Chronic, MinimalMixed Cell Focus

* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3,4-10 ]* Skin Inflammation Chronic Active, Moderate

[ Inflammation TGLs = 2,5,6-7+14+15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 409

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ANIMAL ID: 306 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53874

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 410

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ANIMAL ID: 307 TRT#: 4 SEX: Female DAY ON TEST: 470DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53875

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Mammary Gland * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Thymus * Thyroid Gland* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-1 ]* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-5 ]* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MinimalInflammation Chronic Active, MinimalLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, MildThrombosis Minimal

* Ovary Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 411

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ANIMAL ID: 307 TRT#: 4 SEX: Female DAY ON TEST: 470DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53875

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6,7-6 ]* Stomach, Glandular Necrosis Mild

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 412

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ANIMAL ID: 308 TRT#: 4 SEX: Female DAY ON TEST: 712DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53876

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, MildMixed Cell Focus

* Lung Alveolar Epith Hyperplasia Mild* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,3,5-14+15+16 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Thyroid Gland C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 308 TRT#: 4 SEX: Female DAY ON TEST: 712DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53876

ORGAN AND ACCOUNTABLE SITE STATUS

Animal Note: TGL 4 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 309 TRT#: 4 SEX: Female DAY ON TEST: 653DOSE: 25 ppm DISP: Natural Death HISTO: 53877

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Harderian Gland* Intestine Large, Rectum * Intestine Small, Duodenum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

AUTO PRECLUDES DIAG.* Eye * Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Ileum* Intestine Small, Jejunum

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Minimal

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 1-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 415

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ANIMAL ID: 310 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53878

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal

Mesothelioma Malignant[ Mesothelioma Malignant TGLs = 4,8-16+6 ]

* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, MinimalMixed Cell Focus

[ Mixed Cell Focus TGLs = 15-14 ]* Lung Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 6,7-4+5 ]* Lymph Node, Mediastinal Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 3-3 ]* Mammary Gland Carcinoma Multiple

Fibroadenoma Multiple[ Carcinoma TGLs = 11,12-20+19 ][ Fibroadenoma TGLs = 9,10,13-22+23+21+15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 416

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ANIMAL ID: 310 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53878

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 14-10 ]

Pleura Mesothelioma MalignantSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 2,5-18+17 ]* Thyroid Gland C Cell Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 311 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53879

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Moderate* Liver Clear Cell Focus

Inflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-15 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 418

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ANIMAL ID: 311 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53879

ORGAN AND ACCOUNTABLE SITE STATUS

* Ovary Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-6 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Mild

Vagina Granular Cell Tumor Benign[ Granular Cell Tumor Benign TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 419

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ANIMAL ID: 312 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53880

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Moderate* Kidney Nephropathy Minimal* Liver Angiectasis Mild

Basophilic FocusClear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2,3-14+15+16 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 4-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 420

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ANIMAL ID: 312 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53880

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 6-10 ]

* Spleen Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 421

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ANIMAL ID: 313 TRT#: 4 SEX: Female DAY ON TEST: 541DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53881

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Lymph Node, Mesenteric * Ovary* Pancreas * Parathyroid Gland * Skin * Stomach, Forestomach* Stomach, Glandular * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONSBlood Vessel Aorta Schwannoma Malignant Metastatic (Heart)

* Eye Retina Atrophy Mild* Harderian Gland Schwannoma Malignant Metastatic (Heart)

[ Schwannoma Malignant TGLs = 6-13 ]* Heart Schwannoma Malignant* Kidney Schwannoma Malignant Metastatic (Heart)* Larynx Schwannoma Malignant Metastatic (Heart)* Liver Basophilic Focus

Fibrosis Focal, ModerateInflammation Chronic, Minimal

[ Inflammation TGLs = 11-15 ]* Lung Schwannoma Malignant Metastatic (Heart)* Mammary Gland Fibroadenoma Multiple

Schwannoma Malignant Metastatic (Heart)[ Fibroadenoma TGLs = 1,2-17+19 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 13,14-16+7 ]

* Nose Turbinate Atrophy MildTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 422

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ANIMAL ID: 313 TRT#: 4 SEX: Female DAY ON TEST: 541DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53881

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 7-10 ]

* Salivary Glands Schwannoma Malignant Metastatic (Heart)[ Schwannoma Malignant TGLs = 5-18 ]

Skeletal Muscle Schwannoma Malignant Metastatic (Heart)[ Schwannoma Malignant TGLs = 3-16 ]

* Spleen Schwannoma Malignant Metastatic (Heart)[ Schwannoma Malignant TGLs = 12-6 ]

* Thyroid Gland Schwannoma Malignant Metastatic (Heart)* Trachea Schwannoma Malignant Metastatic (Heart)

PRIMARY CAUSE OF DEATH - Heart Schwannoma MalignantAnimal Note: TGLs 8,9,10 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 423

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ANIMAL ID: 314 TRT#: 4 SEX: Female DAY ON TEST: 719DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53882

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Larynx* Lung * Lymph Node, Mesenteric * Ovary * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

INSUFFICIENT TISSUE* Thymus

OBSERVATIONS* Heart Cardiomyopathy Minimal* Islets, Pancreatic Hyperplasia Moderate* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, MildMixed Cell Focus

[ Fatty Change TGLs = 4-6 ][ Mixed Cell Focus TGLs = 3-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 2-14 ]

* Nose Turbinate Atrophy ModerateForeign Body

Turbinate Hyperostosis MinimalRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 424

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ANIMAL ID: 314 TRT#: 4 SEX: Female DAY ON TEST: 719DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53882

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Acinus Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]* Thyroid Gland Follicular Cel Adenoma

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 425

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ANIMAL ID: 315 TRT#: 4 SEX: Female DAY ON TEST: 571DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53883

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 6-9 ]Peritoneum Inflammation Acute, Moderate

[ Inflammation TGLs = 3-6+14 ]* Pituitary Gland Pars Distalis Angiectasis Moderate

Pars Distalis Hyperplasia Moderate[ Angiectasis TGLs = 2-10 ]

* Spleen Inflammation Acute, Mild[ Inflammation TGLs = 4-6 ]

* Stomach, Forestomach Hyperplasia Squamous, Moderate* Stomach, Glandular Necrosis Mild* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 426

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ANIMAL ID: 315 TRT#: 4 SEX: Female DAY ON TEST: 571DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53883

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Spleen InflammationAnimal Note: TGLs 1,5,6,7 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 316 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53884

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild

Pheochromocytoma Benign* Clitoral Gland Hyperplasia Minimal* Eye Retina Atrophy Marked

Cataract Moderate[ Cataract TGLs = 1-13 ]

* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, MinimalMixed Cell Focus

[ Clear Cell Focus TGLs = 4-6+18 ][ Fatty Change TGLs = 4-18 ][ Mixed Cell Focus TGLs = 4-18 ]

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma Multiple

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 428

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ANIMAL ID: 316 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53884

ORGAN AND ACCOUNTABLE SITE STATUS

[ Fibroadenoma TGLs = 2,3-14+15 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Pancreas Acinus Atrophy Marked* Pituitary Gland Pars Distalis Hyperplasia Moderate* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 317 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53885

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Bronchial * Ovary* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Adrenal Medulla Hyperplasia Mild* Clitoral Gland Adenoma

[ Adenoma TGLs = 1-14 ]* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusInflammation Chronic, Mild

[ Basophilic Focus TGLs = 6-6 ][ Clear Cell Focus TGLs = 6-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Mesenteric Hyperplasia Lymphoid, Marked* Mammary Gland Fibroadenoma

Hyperplasia Mild[ Fibroadenoma TGLs = 9-23 ][ Hyperplasia TGLs = 3,4,8,9-16+17+18+19+20+21+22+23 ]

* Nose Turbinate Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 317 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53885

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Acinus Hyperplasia Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Thyroid Gland C Cell Carcinoma* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 7-10 ]

Animal Note: TGL 2 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 318 TRT#: 4 SEX: Female DAY ON TEST: 717DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53886

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Mammary Gland * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Eye Retina Atrophy Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Angiectasis Mild

Basophilic FocusFatty Change Diffuse, MildInflammation Chronic, MinimalMixed Cell Focus

[ Basophilic Focus TGLs = 2-6 ][ Mixed Cell Focus TGLs = 2-6 ]

* Lung Alveolar Epith Hyperplasia MarkedMesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 318 TRT#: 4 SEX: Female DAY ON TEST: 717DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53886

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Endometrium Hyperplasia Cystic, Moderate

[ Hyperplasia TGLs = 1-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 319 TRT#: 4 SEX: Female DAY ON TEST: 661DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53887

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Brain Carcinoma Metastatic (Pituitary Gland)* Heart Cardiomyopathy Minimal* Kidney Fibrosis Mild

Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2-14+15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MinimalOlfactory Epi Metaplasia Respiratory, Mild

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Carcinoma

[ Carcinoma TGLs = 3-10 ]* Thyroid Gland C Cell Hyperplasia Mild* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 4-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 320 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53888

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Kidney * Larynx * Lung * Lymph Node, Mesenteric* Mammary Gland * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Benign* Clitoral Gland Adenoma

[ Adenoma TGLs = 2-14 ]* Eye Degeneration Marked

[ Degeneration TGLs = 1-13 ]* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Angiectasis Moderate[ Angiectasis TGLs = 3-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 321 TRT#: 4 SEX: Female DAY ON TEST: 451DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53889

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Mammary Gland * Ovary * Pancreas * Parathyroid Gland* Pituitary Gland * Salivary Glands * Skin * Stomach, Forestomach* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild* Kidney Infarct Mild

Nephropathy Minimal[ Infarct TGLs = 4-7 ]

* Liver Fatty Change Diffuse, MildInflammation Chronic, MinimalLeukemia MononuclearNecrosis Mild

[ Leukemia Mononuclear TGLs = 2-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, MildThrombosis Mild

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 321 TRT#: 4 SEX: Female DAY ON TEST: 451DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53889

ORGAN AND ACCOUNTABLE SITE STATUS

* Stomach, Glandular Necrosis Minimal[ Necrosis TGLs = 3-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 322 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53890

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Kidney* Larynx * Lung * Lymph Node, Mesenteric * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-15+16 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 323 TRT#: 4 SEX: Female DAY ON TEST: 709DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53891

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Clitoral Gland Adenoma

[ Adenoma TGLs = 2-15 ]* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, MildLeukemia MononuclearMixed Cell Focus

[ Leukemia Mononuclear TGLs = 4-6+17 ][ Mixed Cell Focus TGLs = 7-17 ]

* Lymph Node, Mediastinal Hyperplasia Plasma Cell, Mild[ Hyperplasia TGLs = 3-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-17 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 439

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ANIMAL ID: 323 TRT#: 4 SEX: Female DAY ON TEST: 709DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53891

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 6-10 ]

* Spleen Leukemia Mononuclear* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 324 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53892

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Mammary Gland * Ovary * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Adrenal Medulla Hyperplasia Mild* Clitoral Gland Adenoma* Heart Cardiomyopathy Mild* Kidney Nephropathy Marked* Liver Basophilic Focus

Clear Cell FocusDegeneration Cystic, ModerateEosinophilic FocusFatty Change Diffuse, MinimalHepatodiaphragmatic NoduleInflammation Chronic, Minimal

[ Basophilic Focus TGLs = 3-15 ][ Clear Cell Focus TGLs = 3-15 ][ Hepatodiaphragmatic Nodule TGLs = 2-14 ]

* Nose Turbinate Atrophy ModerateForeign Body

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 324 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53892

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Acinus Adenoma* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Adenoma

[ Adenoma TGLs = 1-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 325 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53893

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Pancreas * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Adrenal Medulla Pheochromocytoma Benign* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Larynx Inflammation Chronic Active, Moderate

Metaplasia Squamous, Moderate* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Minimal

[ Basophilic Focus TGLs = 5-6 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-14+15+16 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3,6-7+14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Granulosa-Theca Tumor Benign

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 325 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53893

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 326 TRT#: 4 SEX: Female DAY ON TEST: 661DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53894

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Clitoral Gland* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Brain Hydrocephalus Mild* Kidney Nephropathy Mild* Liver Angiectasis Mild

Basophilic FocusFatty Change Diffuse, MildInflammation Chronic, Moderate

Mesentery Inflammation Chronic Active, Mild[ Inflammation TGLs = 3-10 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Minimal

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 2-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 327 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53895

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Kidney* Larynx * Lung * Lymph Node, Mesenteric * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hematopoietic Cell Proliferation Moderate* Clitoral Gland Adenoma* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, MinimalMixed Cell Focus

[ Clear Cell Focus TGLs = 3-19 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 2-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Skin Subcut Tiss Schwannoma Malignant

[ Schwannoma Malignant TGLs = 1-15+16+17+18 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 328 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53896

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Ovary* Pancreas * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

INSUFFICIENT TISSUE* Pituitary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalHepatodiaphragmatic NoduleInflammation Chronic, Minimal

[ Hepatodiaphragmatic Nodule TGLs = 2-6 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-7 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Parathyroid Gland Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 328 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53896

ORGAN AND ACCOUNTABLE SITE STATUS

* Thymus Thymoma Benign[ Thymoma Benign TGLs = 1-3 ]

* Thyroid Gland C Cell CarcinomaC Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 329 TRT#: 4 SEX: Female DAY ON TEST: 535DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53897

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Kidney * Larynx * Mammary Gland* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Minimal* Clitoral Gland Adenoma

[ Adenoma TGLs = 5-9 ]* Heart Thrombosis Moderate

[ Thrombosis TGLs = 4-6 ]* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, MinimalLeukemia MononuclearNecrosis Minimal

[ Leukemia Mononuclear TGLs = 1-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, MildThrombosis Marked

* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 329 TRT#: 4 SEX: Female DAY ON TEST: 535DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53897

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 2-10 ]* Spleen Leukemia Mononuclear* Stomach, Forestomach Necrosis Mild* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 330 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53898

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Adenoma

Carcinoma* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, MildMixed Cell Focus

[ Mixed Cell Focus TGLs = 3-6 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, ModerateOral Mucosa Squamous Cell Papilloma

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Skin Subcut Tiss Neural Crest Tumor[ Neural Crest Tumor TGLs = 4-16 ]

* Spleen Inflammation Granulomatous, Marked[ Inflammation TGLs = 1-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 330 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53898

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 452

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ANIMAL ID: 331 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53899

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Heart Cardiomyopathy Mild* Kidney Renal Tubule Hyperplasia Mild

Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MinimalLeukemia Mononuclear

* Lung Bronchiole Hyperplasia MildInflammation Chronic Active, MinimalLeukemia Mononuclear

[ Inflammation TGLs = 8-5 ]* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-3 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-15+16+14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 453

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ANIMAL ID: 331 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53899

ORGAN AND ACCOUNTABLE SITE STATUS

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3,7-7+14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 6-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Spleen Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 454

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ANIMAL ID: 332 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53900

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Kidney * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MildMixed Cell Focus

[ Basophilic Focus TGLs = 2-6 ][ Mixed Cell Focus TGLs = 2-6 ]

* Lung Bronchiole Hyperplasia Mild* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 4-16 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 455

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ANIMAL ID: 333 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53901

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Ovary * Pancreas * Parathyroid Gland * Pituitary Gland* Salivary Glands * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Clitoral Gland Adenoma

Hyperplasia Moderate* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

[ Basophilic Focus TGLs = 7-14 ]* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 2,3,4-15+16+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-17 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 456

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ANIMAL ID: 333 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53901

ORGAN AND ACCOUNTABLE SITE STATUS

* Skin Basal Cell Adenoma[ Basal Cell Adenoma TGLs = 1-14 ]

* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 457

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ANIMAL ID: 334 TRT#: 4 SEX: Female DAY ON TEST: 689DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53902

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Brain Carcinoma Metastatic (Pituitary Gland)* Clitoral Gland Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MildFatty Change FocalInflammation Chronic, MildMixed Cell Focus

[ Mixed Cell Focus TGLs = 4-19 ]* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-14+15+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-20 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 458

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ANIMAL ID: 334 TRT#: 4 SEX: Female DAY ON TEST: 689DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53902

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Carcinoma

[ Carcinoma TGLs = 5-10 ]* Thyroid Gland Follicular Cel Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 459

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ANIMAL ID: 335 TRT#: 4 SEX: Female DAY ON TEST: 639DOSE: 25 ppm DISP: Natural Death HISTO: 53903

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Duodenum * Larynx* Lung * Lymph Node, Mesenteric * Pancreas * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Thymus* Thyroid Gland * Trachea * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Parathyroid Gland

AUTO PRECLUDES DIAG.* Intestine Small, Ileum * Intestine Small, Jejunum

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Intestine Large, Rectum Leiomyosarcoma Metastatic (Vagina)* Islets, Pancreatic Carcinoma

[ Carcinoma TGLs = 3-6 ]* Kidney Hydronephrosis Moderate

Mineralization ModeratePapilla Necrosis Mild

Nephropathy Moderate[ Hydronephrosis TGLs = 4-7 ]

* Liver Basophilic FocusInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-16 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 7-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 460

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ANIMAL ID: 335 TRT#: 4 SEX: Female DAY ON TEST: 639DOSE: 25 ppm DISP: Natural Death HISTO: 53903

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Mild* Ovary Bursa Dilatation Mild

[ Dilatation TGLs = 5-9 ]* Pituitary Gland Pars Distalis Hyperplasia Mild

[ Hyperplasia TGLs = 2-10 ]* Stomach, Glandular Mineralization Moderate* Urinary Bladder Leiomyosarcoma Metastatic (Vagina)

Vagina Leiomyosarcoma[ Leiomyosarcoma TGLs = 6-14 ]

PRIMARY CAUSE OF DEATH - Vagina Leiomyosarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 336 TRT#: 4 SEX: Female DAY ON TEST: 551DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53904

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Kidney * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Eosinophilic FocusInflammation Chronic, MinimalMixed Cell Focus

[ Mixed Cell Focus TGLs = 4-14 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-15+16+17+18+19 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Mild* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 5-9 ]* Pancreas Acinus Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 337 TRT#: 4 SEX: Female DAY ON TEST: 639DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 63905

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Clitoral Gland Inflammation Chronic Active, Mild* Eye Retina Atrophy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Mild

[ Basophilic Focus TGLs = 3-6 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 2-9 ]* Pancreas Acinus Atrophy Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 337 TRT#: 4 SEX: Female DAY ON TEST: 639DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 63905

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 338 TRT#: 4 SEX: Female DAY ON TEST: 625DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53906

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Bone Osteoma

[ Osteoma TGLs = 6-14 ]* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-15+16 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Thyroid Gland C Cell Adenoma* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 7-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 339 TRT#: 4 SEX: Female DAY ON TEST: 633DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53907

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Mild

* Mammary Gland Galactocele Moderate[ Galactocele TGLs = 6-9 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 340 TRT#: 4 SEX: Female DAY ON TEST: 694DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53908

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Larynx Inflammation Chronic Active, Moderate

Metaplasia Squamous, Moderate* Liver Basophilic Focus

Fatty Change Diffuse, MildHepatodiaphragmatic NoduleInflammation Chronic, MildMixed Cell Focus

[ Hepatodiaphragmatic Nodule TGLs = 7-16 ]* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Bronchial Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 2-3 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 467

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ANIMAL ID: 340 TRT#: 4 SEX: Female DAY ON TEST: 694DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53908

ORGAN AND ACCOUNTABLE SITE STATUS

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 3-17 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 8-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 341 TRT#: 4 SEX: Female DAY ON TEST: 600DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53909

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear* Liver Basophilic Focus

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-6 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-7 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-14+16 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Hyperplasia MildLeukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 469

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ANIMAL ID: 341 TRT#: 4 SEX: Female DAY ON TEST: 600DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53909

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-15 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 470

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ANIMAL ID: 342 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53910

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Benign* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Mild

[ Basophilic Focus TGLs = 4-14 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-15+16+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-14 ]* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 6-10 ]* Thyroid Gland C Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 471

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ANIMAL ID: 342 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53910

ORGAN AND ACCOUNTABLE SITE STATUS

[ Carcinoma TGLs = 3-3 ]* Uterus Polyp Stromal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 472

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ANIMAL ID: 343 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53911

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Degeneration Cystic, ModerateInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 343 TRT#: 4 SEX: Female DAY ON TEST: 733DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53911

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis AdenomaLeukemia Mononuclear

[ Adenoma TGLs = 5-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Mild* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 474

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ANIMAL ID: 344 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53912

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Ovary * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia Mild* Adrenal Medulla Pheochromocytoma Benign* Eye Degeneration Marked

[ Degeneration TGLs = 2-13 ]* Heart Cardiomyopathy Minimal* Kidney Renal Tubule Hyperplasia Moderate

Nephropathy Moderate* Liver Clear Cell Focus

Eosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, Minimal

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Acinus Atrophy Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 475

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ANIMAL ID: 344 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53912

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis AdenomaPars Distalis Angiectasis Moderate

[ Adenoma TGLs = 3-10 ][ Angiectasis TGLs = 3-10 ]

* Thyroid Gland C Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 345 TRT#: 4 SEX: Female DAY ON TEST: 613DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53913

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Bronchial* Lymph Node, Mesenteric * Ovary * Parathyroid Gland * Salivary Glands* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 3-16 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 1-15 ]* Spleen Hyperplasia Lymphoid, Moderate

[ Hyperplasia TGLs = 2-14 ]

PRIMARY CAUSE OF DEATH - Skin Subcut Tiss Fibroma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 346 TRT#: 4 SEX: Female DAY ON TEST: 691DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53914

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Harderian Gland * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Stomach, Glandular * Trachea

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

INSUFFICIENT TISSUE* Intestine Large, Cecum

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Moderate

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Eye Leukemia Mononuclear* Heart Cardiomyopathy Mild

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, ModerateLeukemia MononuclearNecrosis Mild

[ Leukemia Mononuclear TGLs = 9-6 ]* Lung Leukemia Mononuclear

Lymph Node Deep Cervical Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-7 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 346 TRT#: 4 SEX: Female DAY ON TEST: 691DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53914

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-21 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 10-22 ]

* Mammary Gland Fibroadenoma MultipleGalactocele MildLeukemia Mononuclear

[ Fibroadenoma TGLs = 1,6-14+15+16+19 ][ Galactocele TGLs = 2-21 ]

* Nose Turbinate Atrophy ModerateForeign Body

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 7-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-18 ]

* Stomach, Forestomach Leukemia Mononuclear* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Moderate* Urinary Bladder Leukemia Mononuclear* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 8-10 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 347 TRT#: 4 SEX: Female DAY ON TEST: 610DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53915

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas * Parathyroid Gland* Pituitary Gland * Salivary Glands * Skin * Spleen* Thymus * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hematopoietic Cell Proliferation Moderate

Hyperplasia Mild[ Hematopoietic Cell Proliferation TGLs = 10-7 ]

* Kidney Mesenchymal Tumor Malignant[ Mesenchymal Tumor Malignant TGLs = 8-7+14 ]

* Larynx Metaplasia Squamous, Minimal* Liver Hepatodiaphragmatic Nodule

Inflammation Chronic, Minimal[ Hepatodiaphragmatic Nodule TGLs = 9-15 ]

* Lung Mesenchymal Tumor Malignant Metastatic (Kidney)* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 4-16 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 7-15 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Mild* Ovary Bursa Dilatation Mild

[ Dilatation TGLs = 5-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 347 TRT#: 4 SEX: Female DAY ON TEST: 610DOSE: 25 ppm DISP: Moribund Sacrifice HISTO: 53915

ORGAN AND ACCOUNTABLE SITE STATUS

* Stomach, Forestomach Ulcer Mild* Stomach, Glandular Necrosis Moderate

[ Necrosis TGLs = 11-10 ]* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 6-10 ]

PRIMARY CAUSE OF DEATH - Kidney Mesenchymal Tumor Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 481

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ANIMAL ID: 348 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53916

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Eye Degeneration Marked

[ Degeneration TGLs = 1-13 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, MinimalMixed Cell Focus

[ Clear Cell Focus TGLs = 3-6 ][ Mixed Cell Focus TGLs = 2-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Angiectasis MildPars Distalis Hyperplasia Mild

[ Angiectasis TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 482

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ANIMAL ID: 348 TRT#: 4 SEX: Female DAY ON TEST: 731DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53916

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland Follicular Cel Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 483

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ANIMAL ID: 349 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53917

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Ovary * Pancreas * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusFatty Change Diffuse, MildHepatodiaphragmatic NoduleInflammation Chronic, Mild

[ Clear Cell Focus TGLs = 3-15 ][ Hepatodiaphragmatic Nodule TGLs = 2-14 ]

* Mammary Gland Fibroadenoma* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 1-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 484

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ANIMAL ID: 350 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53918

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mesenteric * Mammary Gland * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Brain Oligodendroglioma Benign* Clitoral Gland Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Marked* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MinimalMixed Cell Focus

[ Basophilic Focus TGLs = 2-6 ][ Clear Cell Focus TGLs = 2-6 ][ Mixed Cell Focus TGLs = 2-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Mediastinal Carcinoma Metastatic (Thyroid Gland)* Nose Turbinate Atrophy Mild

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 485

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ANIMAL ID: 350 TRT#: 4 SEX: Female DAY ON TEST: 732DOSE: 25 ppm DISP: Terminal Sacrifice HISTO: 53918

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Marked* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 3-9 ]* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Carcinoma

C Cell Hyperplasia Mild[ Carcinoma TGLs = 1-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 486

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ANIMAL ID: 501 TRT#: 6 SEX: Female DAY ON TEST: 583DOSE: 50 ppm DISP: Natural Death HISTO: 53769

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Large, Colon

OBSERVATIONS* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Angiectasis Minimal

Fatty Change Diffuse, MildInflammation Chronic, Mild

* Lung Alveolus Infiltration Cellular Histiocyte, Mild* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-15 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 487

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ANIMAL ID: 501 TRT#: 6 SEX: Female DAY ON TEST: 583DOSE: 50 ppm DISP: Natural Death HISTO: 53769

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 488

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ANIMAL ID: 502 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53770

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Pituitary Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, Mild

[ Clear Cell Focus TGLs = 1,4,5-15+6 ]* Lung Alveolar Epith Metaplasia Squamous, Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 2-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 489

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ANIMAL ID: 503 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53771

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Ovary* Pancreas * Pituitary Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland * Thyroid Gland

OBSERVATIONS* Adrenal Cortex Adenoma

Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 2-6 ]* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, Moderate* Uterus Sarcoma Stromal

[ Sarcoma Stromal TGLs = 1-14+15+16+18+19+20+21+22 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 490

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ANIMAL ID: 504 TRT#: 6 SEX: Female DAY ON TEST: 563DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53772

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, MinimalLeukemia Mononuclear

[ Inflammation TGLs = 6-6 ][ Leukemia Mononuclear TGLs = 5,7-6 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-4+5 ]

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-14 ]

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 15-21 ]* Mammary Gland Galactocele Moderate

[ Galactocele TGLs = 13,14-19+20 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 491

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ANIMAL ID: 504 TRT#: 6 SEX: Female DAY ON TEST: 563DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53772

ORGAN AND ACCOUNTABLE SITE STATUS

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 11,12-17+18 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 9-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 8-15 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Sarcoma Stromal

[ Sarcoma Stromal TGLs = 10-16 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia MononuclearAnimal Note: TGL 6 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 492

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ANIMAL ID: 505 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53773

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Ovary * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Clitoral Gland Adenoma

[ Adenoma TGLs = 2-14 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change FocalInflammation Chronic, Mild

[ Basophilic Focus TGLs = 3-6 ][ Clear Cell Focus TGLs = 3-6 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Angiectasis Mild* Thyroid Gland C Cell Adenoma* Uterus Endometrium Hyperplasia Cystic, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 493

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ANIMAL ID: 506 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53774

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary* Pancreas * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Angiectasis Minimal

Basophilic FocusClear Cell FocusEosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, MildMixed Cell Focus

[ Clear Cell Focus TGLs = 5-6 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-14+15+16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Parathyroid Gland Angiectasis Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 506 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53774

ORGAN AND ACCOUNTABLE SITE STATUS

[ Angiectasis TGLs = 3-3 ]* Pituitary Gland Pars Distalis Hyperplasia Mild

[ Hyperplasia TGLs = 4-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 495

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ANIMAL ID: 507 TRT#: 6 SEX: Female DAY ON TEST: 634DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53775

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Parathyroid Gland * Pituitary Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, MinimalNecrosis Moderate

[ Necrosis TGLs = 4-6 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 6-9 ]Mesentery Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 5-15 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Moderate

Olfactory Epi Metaplasia Respiratory, ModerateThrombosis Mild

* Ovary Mesothelioma Malignant* Pancreas Mesothelioma Malignant

Peritoneum Mesothelioma MalignantSkeletal Muscle Mesothelioma Malignant

[ Mesothelioma Malignant TGLs = 3-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 496

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ANIMAL ID: 507 TRT#: 6 SEX: Female DAY ON TEST: 634DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53775

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Hematopoietic Cell Proliferation ModerateMesothelioma Malignant

PRIMARY CAUSE OF DEATH - Peritoneum Mesothelioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 497

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ANIMAL ID: 508 TRT#: 6 SEX: Female DAY ON TEST: 672DOSE: 50 ppm DISP: Natural Death HISTO: 53776

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Islets, Pancreatic * Kidney* Larynx * Lung * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Pituitary Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum

OBSERVATIONS* Liver Inflammation Chronic, Minimal

[ Inflammation TGLs = 1-6 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 2-9 ]* Thyroid Gland C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - UNCERTAIN

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 498

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ANIMAL ID: 509 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53777

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Parathyroid Gland * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Kidney Nephropathy Minimal* Liver Fatty Change Focal

Inflammation Chronic, MinimalMixed Cell Focus

[ Fatty Change TGLs = 6-6 ][ Mixed Cell Focus TGLs = 5-14 ]

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 2-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 4-9 ]* Pancreas Acinus Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 499

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ANIMAL ID: 509 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53777

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Salivary Glands Basophilic Focus* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 500

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ANIMAL ID: 510 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53778

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, ModerateInflammation Chronic, Mild

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2,3,4-15+16+17+18 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, ModerateOlfactory Epi Metaplasia Squamous, Minimal

* Ovary Bursa Dilatation Marked[ Dilatation TGLs = 6-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 7-10 ]

* Thymus Thymoma Malignant[ Thymoma Malignant TGLs = 5-3+14 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 501

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ANIMAL ID: 511 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53779

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusHepatodiaphragmatic NoduleInflammation Chronic, MinimalLeukemia MononuclearMixed Cell Focus

[ Hepatodiaphragmatic Nodule TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-15 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 502

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ANIMAL ID: 511 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53779

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Angiectasis Mild

[ Angiectasis TGLs = 5-10 ]* Spleen Leukemia Mononuclear* Stomach, Forestomach Hyperplasia Squamous, Mild* Thyroid Gland C Cell Carcinoma

C Cell Hyperplasia Mild[ Carcinoma TGLs = 2-3 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 503

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ANIMAL ID: 512 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53780

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Mild

[ Clear Cell Focus TGLs = 4-6 ]* Lung Alveolar Epith Hyperplasia Minimal

Alveolar Epith Metaplasia Squamous, Mild[ Metaplasia TGLs = 3-5 ]

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 2,6-15+16+9 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Atrophy Mild* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 504

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ANIMAL ID: 512 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53780

ORGAN AND ACCOUNTABLE SITE STATUS

Zymbal's Gland Carcinoma[ Carcinoma TGLs = 1-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 505

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ANIMAL ID: 513 TRT#: 6 SEX: Female DAY ON TEST: 621DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53781

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-6 ]

* Lung Alveolar/Bronchiolar AdenomaLeukemia Mononuclear

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 2-15+16 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 506

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ANIMAL ID: 513 TRT#: 6 SEX: Female DAY ON TEST: 621DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53781

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Leukemia Mononuclear* Pancreas Acinus Atrophy Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild

Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-14 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 507

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ANIMAL ID: 514 TRT#: 6 SEX: Female DAY ON TEST: 670DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53782

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Spleen * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Eye Retina Atrophy Moderate

Cataract Mild[ Cataract TGLs = 1-13 ]

* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Angiectasis Mild

Basophilic FocusHepatodiaphragmatic NoduleInflammation Chronic, Minimal

[ Angiectasis TGLs = 8-17 ][ Hepatodiaphragmatic Nodule TGLs = 7-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 2,4-18+15 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 508

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ANIMAL ID: 514 TRT#: 6 SEX: Female DAY ON TEST: 670DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53782

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 6-10 ]

* Skin Keratoacanthoma[ Keratoacanthoma TGLs = 3-14 ]

* Thyroid Gland C Cell Carcinoma[ Carcinoma TGLs = 5-3 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 509

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ANIMAL ID: 515 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53783

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mesenteric * Mammary Gland * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild

Lacrimal Gland Cytoplasmic Alteration Mild[ Cytoplasmic Alteration TGLs = 3-14 ]

* Liver Basophilic FocusFatty Change Diffuse, MinimalHepatodiaphragmatic NoduleInflammation Chronic, MinimalMixed Cell Focus

[ Hepatodiaphragmatic Nodule TGLs = 1-6 ][ Mixed Cell Focus TGLs = 1-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 2-9 ]* Pituitary Gland Pars Distalis Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 510

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ANIMAL ID: 516 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53784

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Bronchial * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Mammary Gland * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, MildMixed Cell Focus

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 1-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 517 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53785

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, ModerateInflammation Chronic, MinimalMixed Cell Focus

[ Basophilic Focus TGLs = 2-6 ][ Eosinophilic Focus TGLs = 2-6 ][ Mixed Cell Focus TGLs = 2-6 ]

* Lung Inflammation Chronic Active, Minimal[ Inflammation TGLs = 1-5 ]

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 5,6-16+17 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Marked

Inflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 517 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53785

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Adenoma* Skin

Note: TGL 4 and 7 were normal subcutaneous fat.* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 513

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ANIMAL ID: 518 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53786

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Parathyroid Gland * Salivary Glands * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Degeneration Cystic, Moderate

Inflammation Chronic, MinimalMixed Cell Focus

[ Degeneration TGLs = 3-6 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Marked[ Dilatation TGLs = 2-9 ]

* Pancreas Acinus Hyperplasia Minimal* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 514

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ANIMAL ID: 518 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53786

ORGAN AND ACCOUNTABLE SITE STATUS

* Skin Hyperkeratosis Mild[ Hyperkeratosis TGLs = 1-14 ]

* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 515

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ANIMAL ID: 519 TRT#: 6 SEX: Female DAY ON TEST: 663DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53787

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Mammary Gland * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Leukemia Mononuclear* Kidney Renal Tubule Adenoma

Nephropathy Minimal* Liver Fatty Change Diffuse, Mild

Bile Duct Hyperplasia MildInflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-6 ]* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-3 ]* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 7-15 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 6-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 516

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ANIMAL ID: 519 TRT#: 6 SEX: Female DAY ON TEST: 663DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53787

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-14 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 517

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ANIMAL ID: 520 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53788

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Kidney * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Minimal* Heart Cardiomyopathy Mild

[ Cardiomyopathy TGLs = 2-6 ]* Liver Basophilic Focus

Eosinophilic FocusInflammation Chronic, MinimalMixed Cell Focus

[ Basophilic Focus TGLs = 4-6 ][ Mixed Cell Focus TGLs = 4,6-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14+15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Granulosa Cell Tumor Malignant[ Granulosa Cell Tumor Malignant TGLs = 5-9 ]

* Pituitary Gland Pars Distalis Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 518

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ANIMAL ID: 520 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53788

ORGAN AND ACCOUNTABLE SITE STATUS

[ Hyperplasia TGLs = 3-10 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 519

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ANIMAL ID: 521 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53789

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Clitoral Gland Adenoma

[ Adenoma TGLs = 2-14 ]* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Fatty Change FocalInflammation Chronic, Mild

[ Clear Cell Focus TGLs = 4-6 ]* Lung Alveolar/Bronchiolar Adenoma

Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-15 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-7 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 520

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ANIMAL ID: 521 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53789

ORGAN AND ACCOUNTABLE SITE STATUS

[ Dilatation TGLs = 3-9 ]* Pancreas Acinus Atrophy Marked* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 6-10 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 521

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ANIMAL ID: 522 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53790

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MinimalMixed Cell Focus

[ Basophilic Focus TGLs = 7-6 ][ Clear Cell Focus TGLs = 7-6 ][ Mixed Cell Focus TGLs = 7-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Lymph Node, Mediastinal Hemorrhage Mild

[ Hemorrhage TGLs = 3-3 ]* Mammary Gland Carcinoma

Fibroadenoma[ Carcinoma TGLs = 2-15 ][ Fibroadenoma TGLs = 1-14 ]

Mesentery Fat Hemorrhage MildFat Necrosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 522

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ANIMAL ID: 522 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53790

ORGAN AND ACCOUNTABLE SITE STATUS

[ Hemorrhage TGLs = 4-14 ][ Necrosis TGLs = 5-7 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 8-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 6-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 523

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ANIMAL ID: 523 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53791

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Medulla Pheochromocytoma Benign

Pheochromocytoma Malignant[ Pheochromocytoma Malignant TGLs = 4-7 ]

* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, MildMixed Cell Focus

[ Basophilic Focus TGLs = 3-6 ][ Clear Cell Focus TGLs = 3-6 ]

Lymph Node Deep Cervical Hyperplasia Lymphoid, Mild[ Hyperplasia TGLs = 6-14 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-15 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 524

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ANIMAL ID: 523 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53791

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild

[ Hyperplasia TGLs = 2-10 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 525

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ANIMAL ID: 524 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53792

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mesenteric* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Harderian Gland Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, MinimalMixed Cell Focus

[ Mixed Cell Focus TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-15+16 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 2-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 526

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ANIMAL ID: 524 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53792

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 527

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ANIMAL ID: 525 TRT#: 6 SEX: Female DAY ON TEST: 606DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53793

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Hyperplasia Minimal* Bone Chondroma

[ Chondroma TGLs = 2-12 ]* Kidney Nephropathy Minimal* Liver Eosinophilic Focus

Inflammation Chronic, MinimalNecrosis Mild

[ Necrosis TGLs = 3-14 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Mild

[ Dilatation TGLs = 5-9 ]* Pituitary Gland Pars Distalis Angiectasis Moderate

[ Angiectasis TGLs = 1-10 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 525 TRT#: 6 SEX: Female DAY ON TEST: 606DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53793

ORGAN AND ACCOUNTABLE SITE STATUS

* Uterus Polyp Stromal[ Polyp Stromal TGLs = 6-10 ]

PRIMARY CAUSE OF DEATH - Bone Chondroma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 529

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ANIMAL ID: 526 TRT#: 6 SEX: Female DAY ON TEST: 526DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53794

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Pancreas* Parathyroid Gland * Pituitary Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Minimal* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear* Liver Inflammation Chronic, Minimal

Leukemia MononuclearNecrosis Minimal

* Lung Alveolar/Bronchiolar AdenomaLeukemia Mononuclear

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

Thrombosis Mild* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 2-9 ]* Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 530

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ANIMAL ID: 526 TRT#: 6 SEX: Female DAY ON TEST: 526DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53794

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 1-6 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 531

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ANIMAL ID: 527 TRT#: 6 SEX: Female DAY ON TEST: 563DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53795

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mesenteric * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Hyperplasia Oncocytic, Minimal

Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Mild

* Lung Alveolus Infiltration Cellular Histiocyte, Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 3-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 1-9 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 532

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ANIMAL ID: 528 TRT#: 6 SEX: Female DAY ON TEST: 698DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53796

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Heart Cardiomyopathy Minimal

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Basophilic Focus

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-4+5 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15+16 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-18 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 533

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ANIMAL ID: 528 TRT#: 6 SEX: Female DAY ON TEST: 698DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53796

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Follicle Cyst Mild* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-18 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 534

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ANIMAL ID: 529 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53797

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Parathyroid Gland * Stomach, Glandular * Thyroid Gland* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Intestine Large, Rectum Adenoma

[ Adenoma TGLs = 12-8 ]* Kidney Nephropathy Mild* Liver Angiectasis Moderate

Basophilic FocusClear Cell FocusEosinophilic FocusFatty Change Diffuse, MinimalHepatodiaphragmatic NoduleInflammation Chronic, MildLeukemia Mononuclear

[ Angiectasis TGLs = 8,9,10-6+7+15 ][ Clear Cell Focus TGLs = 6-14 ][ Eosinophilic Focus TGLs = 7-14 ][ Hepatodiaphragmatic Nodule TGLs = 5-6 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,3-14+16+17 ]* Nose Turbinate Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 535

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ANIMAL ID: 529 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53797

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Cyst Moderate

[ Cyst TGLs = 11-9 ]* Pancreas Acinus Atrophy Marked* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Salivary Glands Basophilic Focus* Skin Subcut Tiss Fibroma

[ Fibroma TGLs = 4-9+18+19+20+21+22+23 ]* Spleen Leukemia Mononuclear* Stomach, Forestomach Hyperplasia Squamous, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 536

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ANIMAL ID: 530 TRT#: 6 SEX: Female DAY ON TEST: 514DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53798

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Trachea * Urinary Bladder

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Renal Tubule Necrosis Mild[ Leukemia Mononuclear TGLs = 2-7 ]

* Liver Fatty Change Diffuse, ModerateInflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-17 ]

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-16 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3,4-14+15 ]* Stomach, Glandular Necrosis Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 537

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ANIMAL ID: 530 TRT#: 6 SEX: Female DAY ON TEST: 514DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53798

ORGAN AND ACCOUNTABLE SITE STATUS

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 538

Page 539: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 531 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53799

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Lymph Node, Mesenteric * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Larynx Inflammation Chronic Active, Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Mild

[ Basophilic Focus TGLs = 5-6 ][ Fatty Change TGLs = 5-6 ]

* Lung Bronchiole Hyperplasia MildAlveolar Epith Hyperplasia Mild

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2-14+15+16+17 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 539

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ANIMAL ID: 531 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53799

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Acinus Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 540

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ANIMAL ID: 532 TRT#: 6 SEX: Female DAY ON TEST: 659DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53800

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mesenteric * Mammary Gland * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Eye Retina Atrophy Marked

Cataract Moderate[ Cataract TGLs = 2-13 ]

* Kidney Nephropathy Mild* Liver Basophilic Focus

Degeneration Cystic, MildFatty Change Diffuse, MarkedInflammation Chronic, Minimal

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 541

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ANIMAL ID: 533 TRT#: 6 SEX: Female DAY ON TEST: 603DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53801

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Mammary Gland* Ovary * Parathyroid Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Bone Hyperostosis Moderate* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-15 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-4+5 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 6-7 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MinimalRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Leukemia Mononuclear* Pituitary Gland Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 542

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ANIMAL ID: 533 TRT#: 6 SEX: Female DAY ON TEST: 603DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53801

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 3-10 ]* Spleen Fibrosis Mild

Leukemia Mononuclear[ Fibrosis TGLs = 5-14 ][ Leukemia Mononuclear TGLs = 4-14 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 543

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ANIMAL ID: 534 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53802

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mesenteric* Mammary Gland * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 1-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 544

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ANIMAL ID: 535 TRT#: 6 SEX: Female DAY ON TEST: 726DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53803

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Larynx * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Pituitary Gland

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Islets, Pancreatic Carcinoma

[ Carcinoma TGLs = 13-22 ]* Kidney Nephropathy Mild* Liver Basophilic Focus

Degeneration Cystic, MildHepatocellular AdenomaInflammation Chronic, MildLeukemia MononuclearNecrosis Mild

[ Leukemia Mononuclear TGLs = 8,10,11-23+6 ]* Lung Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 12-21 ]* Mammary Gland Carcinoma

Fibroadenoma[ Carcinoma TGLs = 6-14+15+16 ][ Fibroadenoma TGLs = 7, 9-17+18 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 535 TRT#: 6 SEX: Female DAY ON TEST: 726DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53803

ORGAN AND ACCOUNTABLE SITE STATUS

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4,5-21+22 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation ModerateLeukemia Mononuclear

[ Dilatation TGLs = 3-9 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1-20 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 546

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ANIMAL ID: 536 TRT#: 6 SEX: Female DAY ON TEST: 729DOSE: 50 ppm DISP: Natural Death HISTO: 53804

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Kidney* Larynx * Lung * Lymph Node, Mesenteric * Ovary* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, Minimal

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2,3,4-15+16+14+17 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Acinus Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Stomach, Forestomach Ulcer Mild* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 547

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ANIMAL ID: 537 TRT#: 6 SEX: Female DAY ON TEST: 514DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53805

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Mammary Gland * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, MinimalNecrosis Moderate

[ Necrosis TGLs = 4-6 ]* Lung Hemorrhage Minimal

Sarcoma Metastatic (Skeletal Muscle)[ Hemorrhage TGLs = 2-4 ]

Lymph Node Deep Cervical Hemorrhage Moderate[ Hemorrhage TGLs = 1-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

Skeletal Muscle Sarcoma[ Sarcoma TGLs = 5-15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 548

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ANIMAL ID: 537 TRT#: 6 SEX: Female DAY ON TEST: 514DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53805

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Hematopoietic Cell Proliferation Moderate* Thyroid Gland C Cell Hyperplasia Moderate

PRIMARY CAUSE OF DEATH - Skeletal Muscle Sarcoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 549

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ANIMAL ID: 538 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53806

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Inflammation Chronic, Minimal[ Clear Cell Focus TGLs = 6-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2,3,4-17+16+15+14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 5-9 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 7-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 550

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ANIMAL ID: 539 TRT#: 6 SEX: Female DAY ON TEST: 579DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53807

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-6 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

Deep Cervical Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-14 ][ Leukemia Mononuclear TGLs = 2-17 ]

* Lymph Node, Mandibular Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-16 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 10-8 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 11-15 ]

Mesentery Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 551

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ANIMAL ID: 539 TRT#: 6 SEX: Female DAY ON TEST: 579DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53807

ORGAN AND ACCOUNTABLE SITE STATUS

Fat Necrosis Mild[ Necrosis TGLs = 9-18 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 8-9 ]

* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Angiectasis Mild

[ Angiectasis TGLs = 3-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5,6-14 ]* Stomach, Glandular Leukemia Mononuclear* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 552

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ANIMAL ID: 540 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53808

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Clitoral Gland Adenoma

[ Adenoma TGLs = 9-16 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, MildMixed Cell Focus

[ Basophilic Focus TGLs = 5-6 ][ Clear Cell Focus TGLs = 5-6 ][ Mixed Cell Focus TGLs = 5-6 ]

* Mammary Gland FibroadenomaGalactocele Moderate

[ Fibroadenoma TGLs = 1-17 ][ Galactocele TGLs = 2-18 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 6-7 ]

* Nose Turbinate Atrophy Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 553

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ANIMAL ID: 540 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53808

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis MildInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Moderate* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Endometrium Carcinoma

[ Carcinoma TGLs = 7-14+16 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 554

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ANIMAL ID: 541 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53809

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary* Parathyroid Gland * Salivary Glands * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Mild

[ Basophilic Focus TGLs = 5-6 ][ Clear Cell Focus TGLs = 3,5-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 2-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-14 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Atrophy Moderate* Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 555

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ANIMAL ID: 541 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53809

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 6-10 ]* Skin Inflammation Chronic Active, Moderate* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 556

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ANIMAL ID: 542 TRT#: 6 SEX: Female DAY ON TEST: 423DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53810

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Kidney * Larynx * Lung * Lymph Node, Bronchial* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary * Parathyroid Gland* Pituitary Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular

INSUFFICIENT TISSUE* Thyroid Gland

OBSERVATIONS* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Inflammation Chronic, Mild* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15+16+17 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Atrophy Minimal

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 557

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ANIMAL ID: 543 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53811

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Heart Cardiomyopathy Minimal* Intestine Large, Colon Cyst Moderate

[ Cyst TGLs = 8-14 ]* Kidney Nephropathy Mild* Liver Clear Cell Focus

Degeneration Cystic, MildFatty Change Diffuse, MinimalInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 5-6 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-14+15 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-7 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Mild

Yolk Sac Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 558

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ANIMAL ID: 543 TRT#: 6 SEX: Female DAY ON TEST: 731DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53811

ORGAN AND ACCOUNTABLE SITE STATUS

[ Dilatation TGLs = 7-9 ][ Yolk Sac Carcinoma TGLs = 6-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 559

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ANIMAL ID: 544 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53812

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Clitoral Gland Hyperplasia Mild

[ Hyperplasia TGLs = 5-9 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

[ Basophilic Focus TGLs = 3-6 ][ Clear Cell Focus TGLs = 3-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 2-14+15 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-7 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Hyperplasia Moderate[ Hyperplasia TGLs = 1-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 544 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53812

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 561

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ANIMAL ID: 545 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53813

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Eye Degeneration Marked

[ Degeneration TGLs = 2-13 ]* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Fatty Change Diffuse, Minimal

Inflammation Chronic, MinimalLeukemia Mononuclear

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild

Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 562

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ANIMAL ID: 545 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53813

ORGAN AND ACCOUNTABLE SITE STATUS

[ Hyperplasia TGLs = 3-10 ]Skeletal Muscle Fibrosis Moderate

[ Fibrosis TGLs = 1-14 ]* Spleen Fibrosis Mild

Leukemia Mononuclear[ Fibrosis TGLs = 4-6 ][ Leukemia Mononuclear TGLs = 5-6 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 563

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ANIMAL ID: 546 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53814

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Bilateral Pheochromocytoma Benign* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 3-6 ]* Lung Alveolar/Bronchiolar Adenoma

Alveolar Epith Hyperplasia Moderate* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 2-16+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 564

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ANIMAL ID: 546 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53814

ORGAN AND ACCOUNTABLE SITE STATUS

* Skin Subcut Tiss Fibroma[ Fibroma TGLs = 1-15 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 565

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ANIMAL ID: 547 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53815

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Ovary* Pancreas * Parathyroid Gland * Salivary Glands * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Eye Cataract Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, Minimal

[ Basophilic Focus TGLs = 4-6 ][ Clear Cell Focus TGLs = 4-6 ]

* Lung Alveolar Epith Hyperplasia Mild[ Hyperplasia TGLs = 3-5 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-7 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 566

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ANIMAL ID: 547 TRT#: 6 SEX: Female DAY ON TEST: 733DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53815

ORGAN AND ACCOUNTABLE SITE STATUS

* Skin Subcut Tiss Sarcoma[ Sarcoma TGLs = 1-7 ]

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 567

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ANIMAL ID: 548 TRT#: 6 SEX: Female DAY ON TEST: 421DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53816

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Brain* Clitoral Gland * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Mammary Gland * Ovary * Pituitary Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Thyroid Gland * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Bone Marrow Leukemia Mononuclear* Eye Retina Atrophy Mild* Heart Leukemia Mononuclear* Intestine Large, Colon Leukemia Mononuclear* Intestine Small, Ileum Leukemia Mononuclear* Kidney Leukemia Mononuclear* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4,5-15+16 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-8 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Atrophy MinimalLeukemia Mononuclear

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-14 ]

* Thymus Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 568

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ANIMAL ID: 548 TRT#: 6 SEX: Female DAY ON TEST: 421DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53816

ORGAN AND ACCOUNTABLE SITE STATUS

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 569

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ANIMAL ID: 549 TRT#: 6 SEX: Female DAY ON TEST: 715DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53817

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Medulla Pheochromocytoma Malignant

[ Pheochromocytoma Malignant TGLs = 7-7 ]* Heart Cardiomyopathy Minimal* Islets, Pancreatic Adenoma* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, Minimal

[ Fatty Change TGLs = 6-18 ]* Lung Pheochromocytoma Malignant Metastatic (Adrenal Medulla)

[ Pheochromocytoma Malignant TGLs = 2-4+5 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15+16 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 3-19 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 570

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ANIMAL ID: 549 TRT#: 6 SEX: Female DAY ON TEST: 715DOSE: 50 ppm DISP: Moribund Sacrifice HISTO: 53817

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 4-9 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 8-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis AdenomaAnimal Note: TGL 5 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 571

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ANIMAL ID: 550 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53818

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Mild

[ Basophilic Focus TGLs = 4-6 ][ Fatty Change TGLs = 4-6 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2,3-14+7 ]

* Nose Turbinate Atrophy ModerateTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Periovarn Tiss Cyst Mild[ Cyst TGLs = 5-9 ]

* Pancreas Inflammation Granulomatous, Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 1-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 572

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ANIMAL ID: 550 TRT#: 6 SEX: Female DAY ON TEST: 732DOSE: 50 ppm DISP: Terminal Sacrifice HISTO: 53818

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 573

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ANIMAL ID: 701 TRT#: 8 SEX: Female DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53669

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lymph Node, Mandibular * Parathyroid Gland * Skin* Trachea

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear

Necrosis Mild* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Bile Duct Hyperplasia Minimal

Inflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Leukemia Mononuclear* Pancreas Leukemia Mononuclear* Pituitary Gland Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 574

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ANIMAL ID: 701 TRT#: 8 SEX: Female DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53669

ORGAN AND ACCOUNTABLE SITE STATUS

* Salivary Glands Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 1,2-14 ]* Stomach, Forestomach Leukemia Mononuclear

Ulcer Marked[ Ulcer TGLs = 6-10 ]

* Stomach, Glandular Leukemia Mononuclear* Thymus Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-3 ]* Thyroid Gland C Cell Hyperplasia Mild* Urinary Bladder Leukemia Mononuclear* Uterus Endometrium Carcinoma

Leukemia Mononuclear[ Carcinoma TGLs = 5-10 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 575

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ANIMAL ID: 702 TRT#: 8 SEX: Female DAY ON TEST: 395DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53670

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Pancreas * Parathyroid Gland * Pituitary Gland * Salivary Glands* Skin * Thymus * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Adrenal Medulla * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear* Liver Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-10 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Mild

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

Thrombosis Moderate* Ovary Bursa Dilatation Mild

Leukemia Mononuclear[ Dilatation TGLs = 1-9 ]

* Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 576

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ANIMAL ID: 702 TRT#: 8 SEX: Female DAY ON TEST: 395DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53670

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 2-6 ]* Stomach, Forestomach Leukemia Mononuclear

Ulcer Moderate* Stomach, Glandular Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 577

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ANIMAL ID: 703 TRT#: 8 SEX: Female DAY ON TEST: 705DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53671

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Angiectasis Mild

Basophilic FocusDegeneration Cystic, MildFatty Change Diffuse, MildInflammation Chronic, MildLeukemia Mononuclear

[ Angiectasis TGLs = 6-18 ][ Degeneration TGLs = 6-18 ][ Leukemia Mononuclear TGLs = 3,4-6+18+19 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14+15+16 ]* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

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ANIMAL ID: 703 TRT#: 8 SEX: Female DAY ON TEST: 705DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53671

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis MildInflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked* Ovary Leukemia Mononuclear* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 2-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-20 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 579

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ANIMAL ID: 704 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53672

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Angiectasis Mild

Basophilic FocusFatty Change Diffuse, MildInflammation Chronic, ModerateLeukemia Mononuclear

[ Angiectasis TGLs = 5-14 ][ Basophilic Focus TGLs = 4-6 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Carcinoma

Fibroadenoma[ Carcinoma TGLs = 1-15 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2,6-7+14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 580

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ANIMAL ID: 704 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53672

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 3-9 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 7-10 ]* Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 581

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ANIMAL ID: 705 TRT#: 8 SEX: Female DAY ON TEST: 704DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53673

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildInflammation Chronic, Moderate

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14+15 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-17 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Marked

Polyp, Inflammatory Marked* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 2-17 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 582

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ANIMAL ID: 705 TRT#: 8 SEX: Female DAY ON TEST: 704DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53673

ORGAN AND ACCOUNTABLE SITE STATUS

Follicular Cel Adenoma

PRIMARY CAUSE OF DEATH - Nose Polyp, Inflammatory

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 583

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ANIMAL ID: 706 TRT#: 8 SEX: Female DAY ON TEST: 725DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53674

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Stomach, Forestomach * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

INSUFFICIENT TISSUE* Intestine Large, Rectum

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear

Necrosis Mild[ Leukemia Mononuclear TGLs = 6-1 ]

* Heart Cardiomyopathy Mild* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Inflammation Chronic, Marked

Leukemia MononuclearNecrosis Mild

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5-14 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1,8-3+15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 584

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ANIMAL ID: 706 TRT#: 8 SEX: Female DAY ON TEST: 725DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53674

ORGAN AND ACCOUNTABLE SITE STATUS

* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 2-16+17 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, MarkedThrombosis Moderate

* Ovary Leukemia Mononuclear* Pituitary Gland Pars Distalis Hyperplasia Mild

Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-14 ]* Stomach, Glandular Necrosis Minimal

[ Necrosis TGLs = 7-10 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 585

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ANIMAL ID: 707 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53675

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, ModerateInflammation Chronic, MinimalMixed Cell Focus

[ Clear Cell Focus TGLs = 7-6 ][ Mixed Cell Focus TGLs = 7-6 ]

* Mammary Gland CarcinomaFibroadenoma Multiple

[ Carcinoma TGLs = 2-16 ][ Fibroadenoma TGLs = 1,2,6-14+16+17+18+19+15 ]

* Nose Turbinate Atrophy MarkedForeign Body

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 586

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ANIMAL ID: 707 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53675

ORGAN AND ACCOUNTABLE SITE STATUS

[ Dilatation TGLs = 3-9 ]* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 587

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ANIMAL ID: 708 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53676

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Kidney* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Mild* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 3,4,5,6-6+14+15+16 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-17+18+19 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 2-7 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild* Thyroid Gland C Cell Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 588

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ANIMAL ID: 709 TRT#: 8 SEX: Female DAY ON TEST: 642DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53677

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Minimal

[ Clear Cell Focus TGLs = 3-6 ]* Lung Alveolar Epith Metaplasia Squamous, Mild* Lymph Node, Bronchial Hyperplasia Lymphoid, Mild

[ Hyperplasia TGLs = 1-3 ]* Lymph Node, Mesenteric Hyperplasia Lymphoid, Mild* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 6-15+16+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, ModerateOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 589

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ANIMAL ID: 709 TRT#: 8 SEX: Female DAY ON TEST: 642DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53677

ORGAN AND ACCOUNTABLE SITE STATUS

Polyp, Inflammatory Mild* Ovary Bursa Dilatation Marked

[ Dilatation TGLs = 4-9 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 2-10 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 590

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ANIMAL ID: 710 TRT#: 8 SEX: Female DAY ON TEST: 567DOSE: 100 ppm DISP: Natural Death HISTO: 53678

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Islets, Pancreatic* Kidney * Larynx * Lymph Node, Mandibular * Lymph Node, Mesenteric* Mammary Gland * Ovary * Parathyroid Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Thymus* Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mediastinal

AUTO PRECLUDES DIAG.* Intestine Large, Cecum * Intestine Small, Ileum * Intestine Small, Jejunum

INSUFFICIENT TISSUE* Pituitary Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Heart Cardiomyopathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, MildNecrosis Minimal

* Lung Alveolus Infiltration Cellular Histiocyte, Minimal* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Atrophy Minimal* Stomach, Glandular Necrosis Mild

[ Necrosis TGLs = 2-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 591

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ANIMAL ID: 710 TRT#: 8 SEX: Female DAY ON TEST: 567DOSE: 100 ppm DISP: Natural Death HISTO: 53678

ORGAN AND ACCOUNTABLE SITE STATUS

* Uterus Polyp Stromal[ Polyp Stromal TGLs = 1-14 ]

PRIMARY CAUSE OF DEATH - UNCERTAIN

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 592

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ANIMAL ID: 711 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53679

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Kidney* Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Islets, Pancreatic Adenoma

[ Adenoma TGLs = 9-6 ]* Liver Clear Cell Focus

Fatty Change Diffuse, MildInflammation Chronic, ModerateMixed Cell Focus

[ Clear Cell Focus TGLs = 7-6 ][ Mixed Cell Focus TGLs = 6-14 ]

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2,3-15+17+18+16 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 8-14 ]* Nose Turbinate Atrophy Marked

Foreign BodyTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 593

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ANIMAL ID: 711 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53679

ORGAN AND ACCOUNTABLE SITE STATUS

* Ovary Bursa Dilatation Mild[ Dilatation TGLs = 4-9 ]

Peritoneum Mesothelium Hyperplasia Minimal* Pituitary Gland Pars Distalis Hyperplasia Mild* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 5-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 594

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ANIMAL ID: 712 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53680

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Minimal* Clitoral Gland Carcinoma* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal

Lacrimal Gland Degeneration Mild[ Degeneration TGLs = 8-22 ]

* Liver Clear Cell FocusDegeneration Cystic, MildFatty Change Diffuse, MildInflammation Chronic, MildLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 11-6 ]* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2,3,4-14+15+16+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5,6,7,10-18+19+20+21 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 595

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ANIMAL ID: 712 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53680

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Mild* Uterus Polyp Stromal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 596

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ANIMAL ID: 713 TRT#: 8 SEX: Female DAY ON TEST: 655DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53681

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Eye Retina Atrophy Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, Mild

[ Basophilic Focus TGLs = 3-6 ][ Clear Cell Focus TGLs = 3-6 ][ Fatty Change TGLs = 3-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 4-15+16+17 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 6-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 597

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ANIMAL ID: 713 TRT#: 8 SEX: Female DAY ON TEST: 655DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53681

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 598

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ANIMAL ID: 714 TRT#: 8 SEX: Female DAY ON TEST: 677DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53682

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Mammary Gland * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate

Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Eye Retina Atrophy Moderate

Cataract Mild[ Cataract TGLs = 5-13 ]

* Kidney Leukemia MononuclearNephropathy Minimal

* Liver Degeneration Cystic, ModerateFatty Change Diffuse, MinimalInflammation Chronic, MildLeukemia MononuclearMixed Cell Focus

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 599

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ANIMAL ID: 714 TRT#: 8 SEX: Female DAY ON TEST: 677DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53682

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 1-9 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 6-10 ]* Spleen Leukemia Mononuclear

Necrosis Moderate[ Leukemia Mononuclear TGLs = 2-14 ][ Necrosis TGLs = 3-15 ]

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 600

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ANIMAL ID: 715 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53683

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Parathyroid Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, ModerateLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-9+15+16+14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 3-9 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 601

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ANIMAL ID: 715 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53683

ORGAN AND ACCOUNTABLE SITE STATUS

* Pancreas Acinus Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Spleen Leukemia Mononuclear* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 602

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ANIMAL ID: 716 TRT#: 8 SEX: Female DAY ON TEST: 703DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53684

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Bone * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Thymus

OBSERVATIONS* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Basophilic Focus

Fatty Change Diffuse, MildBile Duct Hyperplasia Minimal

Inflammation Chronic, MildLeukemia MononuclearNecrosis Mild

[ Leukemia Mononuclear TGLs = 7,11-6+16 ]* Lung Leukemia Mononuclear

Lymph Node Deep Cervical Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-18 ]

* Lymph Node, Mandibular Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-17 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 10-8 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 603

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ANIMAL ID: 716 TRT#: 8 SEX: Female DAY ON TEST: 703DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53684

ORGAN AND ACCOUNTABLE SITE STATUS

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 2-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 8-17 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 9-9 ]* Pituitary Gland Pars Distalis Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-16 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 604

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ANIMAL ID: 717 TRT#: 8 SEX: Female DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53685

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Heart * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Thyroid Gland * Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Kidney Nephropathy Minimal* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MildHepatodiaphragmatic NoduleInflammation Chronic, MarkedLeukemia Mononuclear

[ Hepatodiaphragmatic Nodule TGLs = 8-14 ][ Leukemia Mononuclear TGLs = 9,11-6+18 ]

* Lung Alveolar Epith Hyperplasia MinimalLeukemia Mononuclear

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-17 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateInflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 605

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ANIMAL ID: 717 TRT#: 8 SEX: Female DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53685

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Squamous, Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 10-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3,7-15 ]* Uterus Polyp Stromal

[ Polyp Stromal TGLs = 4-10 ]Vagina Polyp

[ Polyp TGLs = 5-16 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 606

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ANIMAL ID: 718 TRT#: 8 SEX: Female DAY ON TEST: 579DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53686

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Bronchial * Lymph Node, Mesenteric * Mammary Gland* Ovary * Pancreas * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Clitoral Gland Carcinoma

[ Carcinoma TGLs = 2-16 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Necrosis Mild[ Necrosis TGLs = 5-6 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 7-17 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MildOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Hyperplasia Mild* Spleen Hematopoietic Cell Proliferation Marked

[ Hematopoietic Cell Proliferation TGLs = 3-15 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Clitoral Gland Carcinoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 607

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ANIMAL ID: 719 TRT#: 8 SEX: Female DAY ON TEST: 712DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53687

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Clitoral Gland Adenoma

Carcinoma[ Carcinoma TGLs = 1-15 ]

* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, MildMixed Cell Focus

[ Basophilic Focus TGLs = 3-14 ][ Mixed Cell Focus TGLs = 3-14 ]

* Mammary Gland Carcinoma[ Carcinoma TGLs = 2-16 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 5-16 ]

* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 608

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ANIMAL ID: 719 TRT#: 8 SEX: Female DAY ON TEST: 712DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53687

ORGAN AND ACCOUNTABLE SITE STATUS

ChondromaTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

[ Chondroma TGLs = 6-11 ]* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 609

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ANIMAL ID: 720 TRT#: 8 SEX: Female DAY ON TEST: 642DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53688

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Mammary Gland* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

Thrombosis Mild* Ovary Bursa Dilatation Marked

Leukemia Mononuclear[ Dilatation TGLs = 3-15 ]

* Pituitary Gland Pars Distalis AdenomaLeukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 610

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ANIMAL ID: 720 TRT#: 8 SEX: Female DAY ON TEST: 642DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53688

ORGAN AND ACCOUNTABLE SITE STATUS

[ Adenoma TGLs = 8-10 ]* Spleen Leukemia Mononuclear

Necrosis Moderate[ Leukemia Mononuclear TGLs = 4-14 ][ Necrosis TGLs = 5,6,7-14 ]

* Stomach, Forestomach Leukemia Mononuclear* Stomach, Glandular Leukemia Mononuclear

Necrosis Mild* Thymus Leukemia Mononuclear* Thyroid Gland Follicular Cel Hyperplasia Mild

C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 611

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ANIMAL ID: 721 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53689

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Fatty Change Diffuse, MinimalInflammation Chronic, MinimalLeukemia Mononuclear

[ Clear Cell Focus TGLs = 3-6 ]* Lung Alveolar Epith Metaplasia Squamous, Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]* Nose Turbinate Atrophy Marked

Foreign BodyTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Mild[ Dilatation TGLs = 2-9 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 612

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ANIMAL ID: 721 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53689

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 613

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ANIMAL ID: 722 TRT#: 8 SEX: Female DAY ON TEST: 645DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53690

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Stomach, Glandular * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Mild

Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Fatty Change Diffuse, Mild

Inflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 5-15 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildInflammation Chronic Active, Marked

Olfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 614

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ANIMAL ID: 722 TRT#: 8 SEX: Female DAY ON TEST: 645DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53690

ORGAN AND ACCOUNTABLE SITE STATUS

Respirat Epith Metaplasia Squamous, ModerateThrombosis Mild

Oral Mucosa Pharyngeal Hyperplasia Squamous, Moderate[ Hyperplasia TGLs = 6-16 ]

* Ovary Leukemia Mononuclear* Pancreas Acinus Atrophy Mild

Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 615

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ANIMAL ID: 723 TRT#: 8 SEX: Female DAY ON TEST: 670DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53691

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Adenoma* Clitoral Gland Adenoma* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Fatty Change Diffuse, MarkedBile Duct Hyperplasia Minimal

Inflammation Chronic, Moderate[ Fatty Change TGLs = 3-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 616

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ANIMAL ID: 723 TRT#: 8 SEX: Female DAY ON TEST: 670DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53691

ORGAN AND ACCOUNTABLE SITE STATUS

* Thyroid Gland C Cell Carcinoma[ Carcinoma TGLs = 2-3 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 617

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ANIMAL ID: 724 TRT#: 8 SEX: Female DAY ON TEST: 655DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53692

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Parathyroid Gland * Salivary Glands* Skin * Stomach, Glandular * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Bile Duct Hyperplasia Mild

Inflammation Chronic, ModerateLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-6 ]* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-15 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 618

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ANIMAL ID: 724 TRT#: 8 SEX: Female DAY ON TEST: 655DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53692

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, MarkedThrombosis Moderate

* Ovary Bursa Dilatation MarkedLeukemia Mononuclear

[ Dilatation TGLs = 2-9 ]* Pancreas Leukemia Mononuclear* Pituitary Gland Leukemia Mononuclear* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-14 ]* Stomach, Forestomach Hyperplasia Squamous, Mild

Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 619

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ANIMAL ID: 725 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53693

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mesenteric * Mammary Gland* Ovary * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Clitoral Gland Carcinoma

[ Carcinoma TGLs = 1-9 ]* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MildInflammation Chronic, Moderate

[ Clear Cell Focus TGLs = 5-7 ][ Inflammation TGLs = 6-6 ]

* Lung Alveolar Epith Hyperplasia Marked[ Hyperplasia TGLs = 3-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 2-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis MildRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 620

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ANIMAL ID: 725 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53693

ORGAN AND ACCOUNTABLE SITE STATUS

Olfactory Epi Metaplasia Respiratory, Marked* Pancreas Acinus Atrophy Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 4-10 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 621

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ANIMAL ID: 726 TRT#: 8 SEX: Female DAY ON TEST: 628DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53694

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Ovary * Parathyroid Gland* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Kidney Nephropathy Minimal* Liver Inflammation Chronic, Mild

Necrosis Minimal[ Inflammation TGLs = 2,3-6 ]

Lymph Node Renal Lymphoma Malignant[ Lymphoma Malignant TGLs = 6-14 ]

* Lymph Node, Bronchial Lymphoma Malignant[ Lymphoma Malignant TGLs = 4-7 ]

* Lymph Node, Mandibular Lymphoma Malignant[ Lymphoma Malignant TGLs = 1-9 ]

* Lymph Node, Mesenteric Inflammation Granulomatous, Marked[ Inflammation TGLs = 8-8 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 7-15+16 ]

Mesentery Lymphoma Malignant[ Lymphoma Malignant TGLs = 5-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 622

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ANIMAL ID: 726 TRT#: 8 SEX: Female DAY ON TEST: 628DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53694

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Hyperplasia Moderate* Salivary Glands Basophilic Focus* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 623

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ANIMAL ID: 727 TRT#: 8 SEX: Female DAY ON TEST: 717DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53695

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Ovary * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Trachea * Urinary Bladder

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild

Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Mild* Liver Basophilic Focus

Bile Duct Hyperplasia MildInflammation Chronic, ModerateLeukemia MononuclearNecrosis Moderate

[ Leukemia Mononuclear TGLs = 2-6 ]* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 5,6-15+16 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 624

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ANIMAL ID: 727 TRT#: 8 SEX: Female DAY ON TEST: 717DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53695

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 3-10 ]

* Spleen Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-14 ]

* Stomach, Glandular Leukemia MononuclearNecrosis Mild

[ Leukemia Mononuclear TGLs = 7-14 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 625

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ANIMAL ID: 728 TRT#: 8 SEX: Female DAY ON TEST: 683DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53696

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Heart * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Parathyroid Gland * Salivary Glands * Skin* Stomach, Glandular * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Degeneration Cystic, Moderate

Leukemia Mononuclear* Kidney Nephropathy Minimal* Liver Basophilic Focus

Degeneration Cystic, ModerateEosinophilic FocusInflammation Chronic, MinimalLeukemia MononuclearMixed Cell Focus

[ Basophilic Focus TGLs = 6-21 ][ Mixed Cell Focus TGLs = 6-21 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 8-4+5 ]

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 7-22 ]

* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-14+15+16+17+18+19 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 626

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ANIMAL ID: 728 TRT#: 8 SEX: Female DAY ON TEST: 683DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53696

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation MarkedLeukemia Mononuclear

[ Dilatation TGLs = 5-9 ]* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 3-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-22 ]* Stomach, Forestomach Hyperplasia Squamous, Moderate

[ Hyperplasia TGLs = 9-23 ]

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 627

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ANIMAL ID: 729 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53697

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Clitoral Gland Carcinoma* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Clear Cell Focus

Eosinophilic FocusFatty Change Diffuse, MildHepatodiaphragmatic NoduleInflammation Chronic, ModerateMixed Cell Focus

[ Clear Cell Focus TGLs = 4-6 ][ Hepatodiaphragmatic Nodule TGLs = 3-6 ][ Mixed Cell Focus TGLs = 4-6 ]

* Lung Bronchiole Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 5-15 ]* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 628

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ANIMAL ID: 729 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53697

ORGAN AND ACCOUNTABLE SITE STATUS

Foreign BodyTurbinate Hyperostosis MarkedRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Thyroid Gland C Cell AdenomaC Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 629

Page 630: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 730 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53698

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Kidney* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Ovary * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Thyroid Gland * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, MildMixed Cell Focus

[ Clear Cell Focus TGLs = 4-16 ][ Mixed Cell Focus TGLs = 3-6 ]

* Mammary Gland CarcinomaFibroadenoma Multiple

[ Carcinoma TGLs = 1-17+18+19 ][ Fibroadenoma TGLs = 1,5-17+18+19+16 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Hyperplasia Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 630

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ANIMAL ID: 731 TRT#: 8 SEX: Female DAY ON TEST: 669DOSE: 100 ppm DISP: Natural Death HISTO: 53699

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Harderian Gland * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lung * Lymph Node, Mediastinal* Lymph Node, Mesenteric * Ovary * Pancreas * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Parathyroid Gland

AUTO PRECLUDES DIAG.* Eye * Intestine Large, Cecum

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate* Heart Cardiomyopathy Mild* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusEosinophilic FocusFatty Change Diffuse, ModerateInflammation Chronic, Moderate

[ Clear Cell Focus TGLs = 2-6 ][ Fatty Change TGLs = 2-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14 ]

* Nose Respirat Epith AdenomaTurbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 631

Page 632: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 731 TRT#: 8 SEX: Female DAY ON TEST: 669DOSE: 100 ppm DISP: Natural Death HISTO: 53699

ORGAN AND ACCOUNTABLE SITE STATUS

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 3-10 ]

* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 632

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ANIMAL ID: 732 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53700

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Pancreas* Parathyroid Gland * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Moderate

Leukemia MononuclearPheochromocytoma Benign

* Heart Cardiomyopathy Minimal* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Eosinophilic Focus

Hepatocellular AdenomaHepatodiaphragmatic NoduleInflammation Chronic, MildLeukemia MononuclearMixed Cell Focus

[ Hepatodiaphragmatic Nodule TGLs = 10-7 ][ Leukemia Mononuclear TGLs = 8,9-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2,3,4-15+16+17+14 ]* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 633

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ANIMAL ID: 732 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53700

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedRespirat Epith Metaplasia Squamous, MildOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 5-9 ]

* Pituitary Gland Pars Distalis Hyperplasia Mild* Salivary Glands Atrophy Mild* Spleen Fibrosis Mild

Leukemia Mononuclear[ Fibrosis TGLs = 11-14 ][ Leukemia Mononuclear TGLs = 6,7-6 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 634

Page 635: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 733 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53701

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Brain Carcinoma Metastatic (Pituitary Gland)* Heart Cardiomyopathy Minimal* Kidney Renal Tubule Hyperplasia Moderate

Nephropathy Mild* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, ModerateNecrosis Mild

[ Basophilic Focus TGLs = 3-6 ][ Eosinophilic Focus TGLs = 3-6 ][ Necrosis TGLs = 3-6 ]

* Lung Alveolar Epith Hyperplasia Minimal* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-14 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 4-15 ]* Nose Turbinate Atrophy Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 635

Page 636: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 733 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53701

ORGAN AND ACCOUNTABLE SITE STATUS

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation Mild[ Dilatation TGLs = 2-9 ]

* Pituitary Gland Pars Distalis Carcinoma[ Carcinoma TGLs = 5-10 ]

* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 636

Page 637: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 734 TRT#: 8 SEX: Female DAY ON TEST: 701DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53702

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Hyperplasia Mild* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Angiectasis Mild

Basophilic FocusInflammation Chronic, MinimalLeukemia MononuclearMixed Cell Focus

[ Mixed Cell Focus TGLs = 6-20 ]* Lung Alveolar Epith Hyperplasia Minimal

Leukemia MononuclearLymph Node Deep Cervical Leukemia Mononuclear

Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-22 ][ Leukemia Mononuclear TGLs = 15-24 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 14-8 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 637

Page 638: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 734 TRT#: 8 SEX: Female DAY ON TEST: 701DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53702

ORGAN AND ACCOUNTABLE SITE STATUS

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,2,12-14+15+16+18+23 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 7,8,13-22+21+23 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation ModerateLeukemia Mononuclear

[ Dilatation TGLs = 9-9 ]* Pancreas Acinus Hyperplasia Mild

Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 11-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-21 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Adenoma

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 638

Page 639: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 735 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53703

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mesenteric * Mammary Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

INSUFFICIENT TISSUE* Parathyroid Gland

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Clear Cell Focus

Eosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, ModerateMixed Cell Focus

[ Clear Cell Focus TGLs = 3-6 ]* Lung Alveolar Epith Hyperplasia Moderate

[ Hyperplasia TGLs = 5-5 ]* Lymph Node, Mediastinal Ectasia Minimal

[ Ectasia TGLs = 1-3 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, Marked

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 639

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ANIMAL ID: 735 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53703

ORGAN AND ACCOUNTABLE SITE STATUS

Respirat Epith Metaplasia Squamous, MildOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation Marked[ Dilatation TGLs = 2-9 ]

* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 4-10 ]* Thyroid Gland C Cell Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 640

Page 641: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 736 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53704

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Moderate* Heart Cardiomyopathy Minimal* Kidney Nephropathy Moderate* Liver Basophilic Focus

Fatty Change Diffuse, ModerateHepatocellular Adenoma MultipleInflammation Chronic, Minimal

[ Hepatocellular Adenoma TGLs = 3,4-6+14 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2-7+14+15 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MildRespirat Epith Hyperplasia Marked

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 6-10 ]

* Uterus Polyp Stromal[ Polyp Stromal TGLs = 7-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 641

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ANIMAL ID: 736 TRT#: 8 SEX: Female DAY ON TEST: 732DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53704

ORGAN AND ACCOUNTABLE SITE STATUS

Animal Note: TGL 5 = NCL

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 642

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ANIMAL ID: 737 TRT#: 8 SEX: Female DAY ON TEST: 116DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53705

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Kidney * Larynx * Liver * Lung* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Mammary Gland * Ovary* Pancreas * Parathyroid Gland * Pituitary Gland * Salivary Glands* Skin * Spleen * Stomach, Forestomach * Stomach, Glandular* Thymus * Thyroid Gland * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Heart Pericardium Fibrosis Mild

[ Fibrosis TGLs = 2-9 ]* Nose Turbinate Atrophy Moderate

Turbinate Hyperostosis MinimalOlfactory Epi Metaplasia Respiratory, Mild

Pleura Hyperplasia MildInfiltration Cellular Mononuclear Cl, Moderate

PRIMARY CAUSE OF DEATH - Heart Pericardium Fibrosis

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 643

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ANIMAL ID: 738 TRT#: 8 SEX: Female DAY ON TEST: 676DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53706

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Ovary* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Degeneration Cystic, Marked

Eosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, MinimalLeukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-6 ]* Lung Leukemia Mononuclear* Lymph Node, Bronchial Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-6 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,2,8-17+14+18 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 644

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ANIMAL ID: 738 TRT#: 8 SEX: Female DAY ON TEST: 676DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53706

ORGAN AND ACCOUNTABLE SITE STATUS

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, MarkedPolyp, Inflammatory Moderate

* Pancreas Acinus Hyperplasia Mild* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 7-10 ]* Spleen Fibrosis Moderate

Leukemia Mononuclear[ Fibrosis TGLs = 5-16 ][ Leukemia Mononuclear TGLs = 4-16 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Moderate

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 645

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ANIMAL ID: 739 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53707

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Larynx * Lymph Node, Bronchial * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Forestomach* Stomach, Glandular * Trachea * Uterus

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Heart Leukemia Mononuclear

Thrombosis Moderate[ Thrombosis TGLs = 5-6 ]

* Kidney Leukemia MononuclearNephropathy Minimal

* Liver Basophilic FocusHepatodiaphragmatic Nodule

Bile Duct Hyperplasia MinimalInflammation Chronic, MildLeukemia MononuclearNecrosis Minimal

[ Hepatodiaphragmatic Nodule TGLs = 2-6 ][ Leukemia Mononuclear TGLs = 1-6 ]

* Lung Leukemia Mononuclear* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 7-14+15 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 646

Page 647: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 739 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53707

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis MarkedRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MildLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, MarkedThrombosis Mild

* Ovary Bursa Dilatation ModerateLeukemia Mononuclear

[ Dilatation TGLs = 6-9 ]* Pituitary Gland Pars Distalis Adenoma

Leukemia Mononuclear[ Adenoma TGLs = 8-10 ]

* Spleen Fibrosis ModerateLeukemia Mononuclear

[ Fibrosis TGLs = 4-6 ][ Leukemia Mononuclear TGLs = 3-6 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Adenoma* Urinary Bladder Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 647

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ANIMAL ID: 740 TRT#: 8 SEX: Female DAY ON TEST: 697DOSE: 100 ppm DISP: Natural Death HISTO: 53708

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Bone Marrow * Brain * Esophagus* Eye * Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon* Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum* Islets, Pancreatic * Kidney * Larynx * Lung* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Spleen * Stomach, Forestomach * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal * Thymus

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Adrenal Medulla Hyperplasia Mild* Clitoral Gland Adenoma

[ Adenoma TGLs = 2-16 ]* Heart Cardiomyopathy Minimal* Liver Basophilic Focus

Degeneration Cystic, ModerateEosinophilic FocusFatty Change Diffuse, MildInflammation Chronic, MildMixed Cell FocusNecrosis Mild

[ Degeneration TGLs = 6-6 ][ Inflammation TGLs = 5-14 ][ Mixed Cell Focus TGLs = 5-14 ]

* Lymph Node, Bronchial Infiltration Cellular Histiocyte, Mild[ Infiltration Cellular TGLs = 3-3 ]

* Lymph Node, Mesenteric Histiocytic Sarcoma* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-18+19+20+21+22 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 648

Page 649: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 740 TRT#: 8 SEX: Female DAY ON TEST: 697DOSE: 100 ppm DISP: Natural Death HISTO: 53708

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Ovary Bursa Dilatation Moderate[ Dilatation TGLs = 4-15 ]

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 7-10 ]

* Stomach, Glandular Necrosis Minimal[ Necrosis TGLs = 8-17 ]

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 649

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ANIMAL ID: 741 TRT#: 8 SEX: Female DAY ON TEST: 724DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53709

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Lymph Node, Bronchial* Lymph Node, Mesenteric * Ovary * Parathyroid Gland * Pituitary Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Hypertrophy Mild* Clitoral Gland Adenoma* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Angiectasis Mild

Basophilic FocusDegeneration Cystic, MildEosinophilic FocusFatty Change Diffuse, MarkedInflammation Chronic, MildNecrosis Mild

[ Angiectasis TGLs = 8-14 ][ Degeneration TGLs = 8-14 ][ Fatty Change TGLs = 6-6+14 ]

* Lung Alveolar Epith Hyperplasia MinimalThrombosis Minimal

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 1,4,5-17+18+19+20+21+22+23+24+16+14 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 650

Page 651: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 741 TRT#: 8 SEX: Female DAY ON TEST: 724DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53709

ORGAN AND ACCOUNTABLE SITE STATUS

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-7 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Mild

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pancreas Acinus Hyperplasia Mild* Thyroid Gland C Cell Adenoma

C Cell Hyperplasia Mild

PRIMARY CAUSE OF DEATH - Mammary Gland Fibroadenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 651

Page 652: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 742 TRT#: 8 SEX: Female DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53710

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric * Parathyroid Gland* Salivary Glands * Skin * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Trachea * Urinary Bladder* Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Brain Oligodendroglioma Malignant

[ Oligodendroglioma Malignant TGLs = 6-1 ]* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Fatty Change Diffuse, Mild

Hepatodiaphragmatic NoduleInflammation Chronic, Mild

[ Hepatodiaphragmatic Nodule TGLs = 3-6 ][ Inflammation TGLs = 2-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 5-15 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Cyst Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 652

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ANIMAL ID: 742 TRT#: 8 SEX: Female DAY ON TEST: 656DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53710

ORGAN AND ACCOUNTABLE SITE STATUS

[ Cyst TGLs = 1-9 ]* Pancreas Acinus Atrophy Minimal* Pituitary Gland Pars Distalis Hyperplasia Mild* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Brain Oligodendroglioma Malignant

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 653

Page 654: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 743 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53711

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Spleen * Stomach, Forestomach* Stomach, Glandular * Thymus * Thyroid Gland * Trachea* Urinary Bladder * Uterus

MISSING* Clitoral Gland * Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Heart Cardiomyopathy Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusInflammation Chronic, Moderate

[ Basophilic Focus TGLs = 3-6 ][ Clear Cell Focus TGLs = 3-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-9+14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-7 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis ModerateRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 2-10 ]

* Skin Inflammation Chronic Active, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 654

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ANIMAL ID: 744 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53712

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Cortex * Adrenal Medulla * Bone * Bone Marrow* Brain * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Lung * Lymph Node, Mediastinal * Lymph Node, Mesenteric* Pancreas * Parathyroid Gland * Salivary Glands * Skin* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Heart Cardiomyopathy Minimal* Kidney Nephropathy Mild* Liver Basophilic Focus

Eosinophilic FocusFatty Change Diffuse, MinimalInflammation Chronic, Moderate

[ Basophilic Focus TGLs = 3-6 ][ Fatty Change TGLs = 3-6 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis MarkedRespirat Epith Hyperplasia Moderate

Inflammation Chronic Active, MarkedOlfactory Epi Metaplasia Respiratory, Marked

* Ovary Bursa Dilatation Marked[ Dilatation TGLs = 2-9 ]

* Pituitary Gland Pars Distalis Angiectasis Moderate[ Angiectasis TGLs = 4-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 655

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ANIMAL ID: 744 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53712

ORGAN AND ACCOUNTABLE SITE STATUS

* Spleen Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Polyp Stromal

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 656

Page 657: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 745 TRT#: 8 SEX: Female DAY ON TEST: 586DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53713

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Mammary Gland * Parathyroid Gland * Salivary Glands* Skin * Stomach, Forestomach * Stomach, Glandular * Thyroid Gland* Trachea

MISSING* Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Heart Leukemia Mononuclear* Kidney Leukemia Mononuclear

Nephropathy Minimal* Liver Inflammation Chronic, Minimal

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 4-6 ]

* Lung Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 5,6,7-5+4+17 ]

Lymph Node Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 9-16 ]

* Lymph Node, Bronchial Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 1-18 ]

* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis ModerateOlfactory Epi Metaplasia Respiratory, Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 657

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ANIMAL ID: 745 TRT#: 8 SEX: Female DAY ON TEST: 586DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53713

ORGAN AND ACCOUNTABLE SITE STATUS

* Ovary Bursa Dilatation MildLeukemia Mononuclear

[ Dilatation TGLs = 10-9 ]* Pancreas Acinus Atrophy Minimal

Leukemia Mononuclear* Pituitary Gland Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 3-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 8-15 ]* Thymus Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-14 ]* Urinary Bladder Leukemia Mononuclear* Uterus Leukemia Mononuclear

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 658

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ANIMAL ID: 746 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53714

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Brain * Clitoral Gland * Esophagus* Eye * Harderian Gland * Heart * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Parathyroid Gland* Salivary Glands * Skin * Stomach, Forestomach * Stomach, Glandular* Trachea * Urinary Bladder

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Leukemia Mononuclear* Adrenal Medulla Leukemia Mononuclear

Bilateral Pheochromocytoma Benign* Bone Marrow Leukemia Mononuclear* Kidney Renal Tubule Hyperplasia Moderate

Leukemia Mononuclear* Liver Angiectasis Mild

Basophilic FocusClear Cell FocusEosinophilic FocusInflammation Chronic, MinimalLeukemia Mononuclear

[ Basophilic Focus TGLs = 7-6 ][ Clear Cell Focus TGLs = 6-6 ][ Eosinophilic Focus TGLs = 8,9-14+15 ][ Leukemia Mononuclear TGLs = 5-6+14+15 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 13-15 ]* Lymph Node, Mediastinal Leukemia Mononuclear* Lymph Node, Mesenteric Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 659

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ANIMAL ID: 746 TRT#: 8 SEX: Female DAY ON TEST: 731DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53714

ORGAN AND ACCOUNTABLE SITE STATUS

[ Leukemia Mononuclear TGLs = 14-14 ]* Mammary Gland Fibroadenoma

[ Fibroadenoma TGLs = 1-16+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 10-7 ]* Nose Turbinate Atrophy Marked

Turbinate Hyperostosis MarkedInflammation Chronic Active, Minimal

Olfactory Epi Metaplasia Respiratory, Moderate* Ovary Bursa Dilatation Marked

Leukemia Mononuclear[ Dilatation TGLs = 2-9 ]

* Pancreas Leukemia Mononuclear* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 12-10 ]* Spleen Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-14 ]* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Uterus Endometrium Hyperplasia Cystic, Moderate

Leukemia MononuclearPolyp Stromal

[ Hyperplasia TGLs = 3-10 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 660

Page 661: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 747 TRT#: 8 SEX: Female DAY ON TEST: 607DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53715

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Brain * Clitoral Gland* Esophagus * Eye * Harderian Gland * Intestine Large, Cecum* Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum * Intestine Small, Ileum* Intestine Small, Jejunum * Islets, Pancreatic * Larynx * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Stomach, Glandular* Thymus * Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Bone Marrow Leukemia Mononuclear* Heart Cardiomyopathy Moderate* Kidney Infarct Mild

Leukemia MononuclearNephropathy Minimal

[ Infarct TGLs = 9-7 ]* Liver Inflammation Chronic, Mild

Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 8-6 ]

* Lung Leukemia MononuclearLymph Node Pancreatic Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 6-15 ]* Lymph Node, Mediastinal Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 2-3 ]* Lymph Node, Mesenteric Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 12-8 ]* Mammary Gland Fibroadenoma Multiple

[ Fibroadenoma TGLs = 1,10-16+17 ]Mesentery Fat Necrosis Mild

[ Necrosis TGLs = 11-18 ]

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 661

Page 662: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 747 TRT#: 8 SEX: Female DAY ON TEST: 607DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53715

ORGAN AND ACCOUNTABLE SITE STATUS

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis MildRespirat Epith Hyperplasia Minimal

Inflammation Chronic Active, MarkedLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, Marked* Ovary Bursa Dilatation Moderate

[ Dilatation TGLs = 7-9 ]* Pituitary Gland Pars Distalis Hyperplasia Moderate

[ Hyperplasia TGLs = 3-10 ]* Spleen Leukemia Mononuclear

Necrosis Mild[ Leukemia Mononuclear TGLs = 4-14 ][ Necrosis TGLs = 5-14 ]

* Stomach, Forestomach Leukemia MononuclearUlcer Moderate

* Thyroid Gland C Cell Hyperplasia Minimal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 662

Page 663: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 748 TRT#: 8 SEX: Female DAY ON TEST: 691DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53716

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Clitoral Gland * Esophagus * Eye * Harderian Gland* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lung * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Thyroid Gland* Trachea * Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular * Lymph Node, Mediastinal

OBSERVATIONS* Adrenal Cortex Hypertrophy Mild* Heart Cardiomyopathy Minimal* Kidney Nephropathy Minimal* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, ModerateInflammation Chronic, MildMixed Cell Focus

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 2-14 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 3-16 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MinimalOlfactory Epi Metaplasia Respiratory, Moderate

* Pituitary Gland Pars Distalis Adenoma[ Adenoma TGLs = 1-10 ]

PRIMARY CAUSE OF DEATH - Pituitary Gland Pars Distalis Adenoma

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 663

Page 664: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 749 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53717

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Adrenal Medulla * Bone * Bone Marrow * Brain* Esophagus * Eye * Harderian Gland * Heart* Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum * Intestine Small, Duodenum* Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic * Larynx* Lymph Node, Mediastinal * Lymph Node, Mesenteric * Ovary * Pancreas* Parathyroid Gland * Salivary Glands * Skin * Spleen* Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea* Urinary Bladder * Uterus

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild* Clitoral Gland Hyperplasia Mild* Kidney Nephropathy Mild* Liver Basophilic Focus

Clear Cell FocusFatty Change Diffuse, MinimalInflammation Chronic, MildMixed Cell Focus

[ Clear Cell Focus TGLs = 6-6 ][ Mixed Cell Focus TGLs = 6-6 ]

* Lung Alveolar/Bronchiolar Carcinoma Multiple[ Alveolar/Bronchiolar Carcinoma TGLs = 1-5 ]

* Mammary Gland Fibroadenoma Multiple[ Fibroadenoma TGLs = 2,3-14+15+16+17 ]

Mesentery Fat Necrosis Mild[ Necrosis TGLs = 4-7 ]

* Nose Turbinate Atrophy MarkedForeign Body

Turbinate Hyperostosis Moderate

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 664

Page 665: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 749 TRT#: 8 SEX: Female DAY ON TEST: 733DOSE: 100 ppm DISP: Terminal Sacrifice HISTO: 53717

ORGAN AND ACCOUNTABLE SITE STATUS

Respirat Epith Hyperplasia MinimalInflammation Chronic Active, Mild

Olfactory Epi Metaplasia Respiratory, Marked* Pituitary Gland Pars Distalis Adenoma

[ Adenoma TGLs = 5-10 ]* Thyroid Gland C Cell Hyperplasia Mild

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 665

Page 666: P14: Individual Animal Pathology Data for Rats …...* Spleen * Stomach, Forestomach * Stomach, Glandular * Thymus * Trachea * Urinary Bladder MISSING * Lymph Node, Bronchial * Lymph

ANIMAL ID: 750 TRT#: 8 SEX: Female DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53718

ORGAN AND ACCOUNTABLE SITE STATUS

NORMAL* Bone * Clitoral Gland * Esophagus * Eye* Harderian Gland * Intestine Large, Cecum * Intestine Large, Colon * Intestine Large, Rectum* Intestine Small, Duodenum * Intestine Small, Ileum * Intestine Small, Jejunum * Islets, Pancreatic* Larynx * Parathyroid Gland * Salivary Glands * Skin* Stomach, Forestomach * Trachea

MISSING* Lymph Node, Bronchial * Lymph Node, Mandibular

OBSERVATIONS* Adrenal Cortex Hyperplasia Mild

Leukemia MononuclearMetaplasia Osseous, Mild

* Adrenal Medulla Hyperplasia MildLeukemia Mononuclear

* Bone Marrow Leukemia Mononuclear* Brain Leukemia Mononuclear* Heart Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 5-20 ]* Kidney Infarct Mild

Leukemia MononuclearNephropathy Mild

[ Infarct TGLs = 13-7 ]* Liver Eosinophilic Focus

Fatty Change Diffuse, MinimalInflammation Chronic, ModerateLeukemia MononuclearNecrosis Mild

[ Leukemia Mononuclear TGLs = 10,11,12-20+18+6 ]* Lung Leukemia Mononuclear

[ Leukemia Mononuclear TGLs = 4-4+5 ]Lymph Node Deep Cervical Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 666

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ANIMAL ID: 750 TRT#: 8 SEX: Female DAY ON TEST: 698DOSE: 100 ppm DISP: Moribund Sacrifice HISTO: 53718

ORGAN AND ACCOUNTABLE SITE STATUS

Pancreatic Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 3-19 ][ Leukemia Mononuclear TGLs = 15-21 ]

* Lymph Node, Mediastinal Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 2-3 ]

* Lymph Node, Mesenteric Leukemia Mononuclear[ Leukemia Mononuclear TGLs = 14-8 ]

* Mammary Gland Fibroadenoma[ Fibroadenoma TGLs = 1-14+15+16 ]

* Nose Turbinate Atrophy MarkedTurbinate Hyperostosis Moderate

Inflammation Chronic Active, MildLeukemia Mononuclear

Olfactory Epi Metaplasia Respiratory, ModerateThrombosis Minimal

* Ovary Bursa Dilatation ModerateLeukemia Mononuclear

[ Dilatation TGLs = 8-21 ]* Pancreas Leukemia Mononuclear* Pituitary Gland Leukemia Mononuclear* Spleen Fibrosis Moderate

Leukemia Mononuclear[ Fibrosis TGLs = 7-19 ][ Leukemia Mononuclear TGLs = 6-18 ]

* Stomach, Glandular Necrosis Minimal[ Necrosis TGLs = 16-22 ]

* Thymus Leukemia Mononuclear* Thyroid Gland C Cell Hyperplasia Minimal* Urinary Bladder Leukemia Mononuclear* Uterus Polyp Stromal

PRIMARY CAUSE OF DEATH - Spleen Leukemia Mononuclear

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 667

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*** END OF REPORT ***

Experiment Number: 20303 - 05 P14: INDIVIDUAL ANIMAL PATHOLOGY DATA Date Report Requested: 12/12/2011Test Type: CHRONIC Vinylidene chloride Time Report Requested: 09:47:55

Route: RESPIRATORY EXPOSURE WHOLE BODY CAS Number: 75-35-4 First Dose M/F: 06/06/05 / 06/06/05Species/Strain: RATS/F 344/N Lab: BNW

* PROTOCOL REQUIRED TISSUE

Page 668