Ozone TherapyFor COVID – a plausible ”penny costing therapy,

essentially totally safe, very inexpensive, and likely of high

efficacy

(Special thanks to Silvia Menendez and Velio Bocci who graciously provided me slides of their research)

© Robert Rowen, MD 03/2020

Robert Rowen, MD Quote

!“With the exception of diet/nutrition, detoxification, and stress reduction, ozone does more good, for more conditions, than everything I have ever used in medicine - COMBINED.”

!“This is a therapy that supports the body’s own Creator designed healing processes, rather than endure chemicals to suppress symptoms.”

PHYSICO-CHEMICAL PROPERTIES OF OZONE

• SOFT SKY-BLUE COLOR, but in liquid state has a dark blue color

• IRRITATING

• UNSTABLE (at 20 oC thehalf-life is 40 min)

• PUNGENT ACRID SMELL (perceptible at a concentration of 0.005-0.01 ppm)

! BOILING POINT (at 760 mmHg): -111.9 0C

! POWERFUL OXIDANT (the thirdstronguest after fluorine and persulphate)

! MORE SOLUBLE IN WATER THAN OXYGEN (10 times more)

! CHEMICAL SELECTIVITY OF REACTION [in order of preference, lipids (polyunsaturated fattyacids), antioxidants (uric and ascorbic acid, reduced glutathione, alpha-tocopherol, bilirubin), cysteine-rich proteins and carbohydrates].

Ozone mesomeric states in dynamic equilibrium

O

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116 49o , O

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O: .. ::::: : :

..

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.... .. .. ..

..

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..

.... .. ..

7

26,6

55,5

33,3 33,3

62,5 62,5

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10

20

30

40

50

60

70

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Cont

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A (24h) B (72h)Grupos

OOP effect on rat survival in the model of peritoneal sepsis

Ozone here was given BEFORE the insult

A- Sepsis was induced 24 h after the last ozone applicationB- Sepsis was induced 72 h after the last ozone application

Peritoneal sepsis was induced by ip injection of cecal material (0,65 g/kg weight) in the right side of the abdomen. IP (intraperitoneal) O3concentrations of 10, 50 and 100 mg/L and a volume of 80 mL/kg were used (corresponding to doses of 0.8; 4 and 8 mg/kg, respectively).

Since 2006, more than $1500 million has been spent on special drugs to treat multiresistant bacterias and virus. The “superbacteria”, as the methicilin resistant Staphylococcus aureus(MRSA), now cause more than 50% of the infections by Staphylococcus in the United States hospitals.

Survival (%)

Groups

HEPATOTOXICIY (CCl4) (EXPERIMENTAL)

DEMOSTRATED PROTECTION MEDIATED BY O3/O2

DIABETES(EXPERIMENTAL)

ISCHEMIA/REPERFUSIONIN LIVER AND KIDNEYS(EXPERIMENTAL)

ROS

ACUTE NEPHROTOXICITY INDUCED BY CISPLATIN(EXPERIMENTAL)

TOXIC GLOMERULONEPHRITIS INDUCED BY ADRIAMICINE(EXPERIMENTAL)

ENDOTOXIC SHOCK INDUCED BY LPS(EXPERIMENTAL)

LETHAL PERITONITIS(EXPERIMENTAL)

BURNT MOUSE

CHRONIC RENAL INSUFFICIENCY

ANIMAL MODELS

!Yes, I am even getting wonderful results with tough to treat conditions like:

!Lyme!CFIDS!Multiple chemical sensitivity!Even depression!

So Many Different Conditions?

How Can One Modality Do This?

! 1 – Oxygen, the source of all energy! 2 – Immune modulation

0102030405060708090

0 2 4 6 8 10 12 14 16Days

mm H

g

Venous PO2Arterial PO2

Behavior of the venous and arterial oxygen partialpressure during the ozone therapy treatment

Increased a-v O2 difference means greater O2 consumption!

Expression of COX-2 mRNA (after 24 h) in the macrophages of themarginal zone of the PALS (periarteriolar lymphatic sheaths of thespleen), in a model of lethal peritonitis in rats

Without ozone

With ozone(Rowen note: Ozone might be an ideal cox-2 inhibitor – knocks it out without toxic side effects)

Erythrocytes in a ¨pile of coins¨ formation

After ozone application (30 mg/L)

After ozone application (60 mg/L)

In arterial occlusion disease the "pile of coins" erythrocyte formation is typical

Expected Knock out of Spike Proteins by Ozone

Virology. 2009 Oct 25;393(2):265-71. doi: 10.1016/j.virol.2009.07.038. Epub 2009 Aug 29.

SARS-coronavirus spike S2 domain flanked by cysteine residues C822 and C833 is important for activation of membrane fusion.

! C-terminal to this S2 cleavage site is a conserved region flanked by cysteine residues C822 and C833. Here, we investigated the importance of this well conserved region for SARS-CoV S-mediated fusion activation. We show that the residues between C822-C833 are well conserved across all coronaviruses. Mutagenic analysis of SARS-CoV S, combined with cell-cell fusion and pseudotyped virion infectivity assays, showed a critical role for the core-conserved residues C822, D830, L831, and C833. Based on available predictive models, we propose that the conserved domain flanked by cysteines 822 and 833 forms a loop structure that interacts with components of the SARS-CoV S trimer to control the activation of membrane fusion.

Genetic Analysis of Determinants for Spike Glycoprotein Assembly into Murine Coronavirus Virions: Distinct Roles for Charge-Rich and Cysteine-Rich Regions of the Endodomain DOI: 10.1128/JVI.78.18.9904-9917.2004

!Virus is dependent on cysteine rich residues in spike proteins for fusion and entry

Important Role for the Transmembrane Domain of Severe Acute Respiratory Syndrome Coronavirus Spike Protein during Entry Journal of Virology DOI: 10.1128/JVI.80.3.1302-1310.2006

!The spike protein (S) of severe acute respiratory syndrome coronavirus (SARS-CoV) is responsible for receptor binding and membrane fusion. It contains a highly conserved transmembrane domain that consists of three parts: an N-terminal tryptophan-rich domain, a central domain, and a cysteine-rich C-terminal domain.

Oxidation of Amino Acids, Peptides and Proteins by Ozone: A Review Ozone: Science & EngineeringThe Journal of the International Ozone Association Volume 32, 2010 - Issue 2

!The order of reactivity for the oxidation of amino acids by O3 at pH 8 is cysteine > tryptophan ≈ methionine > phenylalanine ≈ histidine > others, with half-lives mostly in the range of milliseconds to tens of seconds (1 mg L-1 O3 dose).

Oxidation of Thiols!SH + SH + O3 > S-S + H2O + O2 and releasing surplus energy

Similar reaction of SH groups and reactive ozonide oxygen species.

the finger

Reduction¬

Kräusslich HG.Cold Spring Harb Perspect Biol. 2011 Oct 1;3(10):a004820. doi: 10.1101/cshperspect.a004820.Role of lipids in virus replication.Lorizate M

! Abstract

! Alterations of membrane lipid composition can block viral release and entry, and certain lipids act as fusion inhibitors, suggesting a potential as antiviral drugs.

! Conslusion: Understanding the manifold roles of lipids in viral replication also led to the discovery of lipid-active compounds as potential antivirals, but current compounds largely lack specificity and are thus unacceptably toxic.

Journal of General Virology (1999), 80, 2861–2865. Printed in Great Britain Free thiol groups are essential for infectivity of human cytomegalovirus

!……free thiol groups on CMV are required for infectivity and may participate in disulfide bond formation during virus entry.

! Ryser et al. (1994) have recently suggested that HIV and its target cell engage in a thiol–disulfide interchange reaction and that reduction of critical disulfide bonds in viral glycoproteins may be the initial event that triggers the conformational changes required for HIV entry.

Ebola is a lipid enveloped virus, with electron rich double bonds and with glycoproteins, vulnerable to ozone!Ozone and/or ozonides might alter the lipid

envelope its contents to destroy ability to enter cells

. -David A Sanders Associate Professor of Biological Sciences Ph.D 1989 -University of California, Berkeley

…..reduction to SH the Ebola glycoprotein complex, GP1 and GP2, is a critical step in

the entry of Ebola virus into cells.” http://bilbo.bio.purdue.edu/~viruswww/Sanders_home/research.html

and personal communication

Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry March 1, 2004; Blood: 103 (5)

! Vaccinia virus entry similarly depends on the reduction of critical disulfides in the core proteins, which disrupts viral structure and allows delivery of the viral core into the cytoplasm.

! Inhibitors of redox-active enzymes can prevent Envconformational change by blocking thiol/disulfide reorganization, thereby inhibiting membrane fusion and subsequent entry.

Ozonides!Ozone may disappear in blood very quickly.

But its reactive species, including hydrogen peroxide may react with viral products

!Increasing oxidants in blood reduces pathogenic opportunists. This has been seen for decades in medical research.

Influenza Pneumonia 1918

!British physician Oliver in India found that infusing dilute hydrogen peroxide intravenously cut the mortality of this lethal condition by 50%. Peroxide disappears instantly in blood. However, the oxidation effects clearly last. He only treated the severe and hopeless cases!

!Lancet, Feb 21, 1920

WHAT ABOUT BACTERIA?

Antimicrobial Effects of Ozonated Water Against Generic E.coli on Swine IntestinesVarying Ozone Concentrations

and Exposure Times SIG International Iowa Food Laboratory in conjunction with Ozone Solutions

Authors: Joel Leusink, Ozone Solutions, Inc. 451 Black Forest Road, Hull, IA 51239 e-mail: joel@ozonesolutions.com George

Kraft, Kraft Science Consulting, 821 Main Street, Boyden,

!Low levels of ozone in water achieve a nearly 100% kill rate within 2 seconds.

Ozone Water Quick Bacteria Kill

INSTANT KILL!Ozone acts on bacteria like a bullet through

the heart of a vertebrate. It kills before there can be any repair process! Bacteria don’t have mechanisms to repair this type of damage.

!In nature, sunlight kills bacteria the same way. UV energy oxidizes their membranes. Bacteria have had billions of years to get resistant to UV, but have not.

Now Compare to Bleach (ClO)Fact Sheet Disinfection Using Chlorine Bleach December, 2011 / OSU Biological Safety / Environmental Health & Safety / 541-737-4557 !Recommended Dilutions and Time ! achieve destruction of most common vegetative bacterial pathogens and

viruses within 2 minutes at room temperatures. A good rule of thumb is 10 minutes of contact time with 10% bleach achieves effective disinfection for most routine applications.

! Ozone accomplishes the same in seconds or less.

! Rowen note: Ebola decontamination was performed with chlorine compounds, with a proven speed of about 1% that of ozone. Same thing is going on with coronavirus.

So why does ozone kill viruses and bacteria, but not our cells?! 1. Our cells are aereobic and made for redox reacions. T.

(SOD, GpX, Catalase, vitamin E and other antioxidants, etc)

! 2. Viruses and most bacteria have none of these. They are inactivated and unable to repair.

!Finally, our cells actually generate reactive oxygen species to slay invaders. Among these are hypochlorite (bleach), hydrogen peroxide, superoxide, singlet oxygen, nitric oxide, and…………

!OZONE!

Published online before print February 24, 2003, 10.1073/pnas.0530251100PNAS | March 18, 2003 | vol. 100 | no. 6 | 3031-3034 From the Cover Chemistry / Biochemistry Investigating antibody-catalyzed ozone generation by human neutrophils Bernard M. Babior,, et al. The Scripps Research Institute, 7 Contributed by Bernard M. Babior, January 14, 2003

“Ozone is actually generated by immune cells (neutrophils) catalyzed by antibodies.

Hence, ozone is a natural substance produced by the body.

Into the Eye of the Cytokine StormMicrobiol. Mol. Biol. Rev. March 2012 vol. 76 no. 1 16-32

!Summary: …..Cytokine storms are associated with a wide variety of infectious and noninfectious diseases. The term was popularized largely in the context of avian H5N1 influenza virus infection, bringing the term into popular media.

! (Ebola kills by cytokine storm.)

Effects of ozone oxidative preconditioning on TNFα levels in serum of mice treated with LPS (endotoxic shock) (O3 as good as Dex)

TNF- α (pg/ml)

TNF Inhibition (%)B:Ozone 30 mg/L (1.2 mg/kg, i.p.)A: Saline solution

C: LPSD: Ozone 5 mg/L (0.2 mg/kg, i.p.) + LPS

E: Ozone 10 mg/L (0.4 mg/kg, i.p.) + LPSF: Ozone 30 mg/L (1.2 mg/kg, i.p.) + LPS

G: Ozone 5 mg/L (0.2 mg/kg, r.i.) + LPSH: Ozone 10 mg/L (0.4 mg/kg, r.i.) + LPS

I: Dexametasone (30 mg/kg) + LPS

* p < 0.05, ** p<0.01 vs. LPS

*

** **

*

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PSDe

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g)+L

PS

Groups

50% 47%37%

77%

TNFα was measured in serum, 1 h after the LPS injection. NO was measured 24 h after the LPS injection

Ip O3 applications exert beneficial effects, avoiding the establishment of a chronic inflammatory response and the consequent oxidative stress.

0

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A B C D E F G H I

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NaCl O3 LPS O3IP O3IP O3IP O3 RI O3 RI Dex

!Because of the foregoing, I believed ozone therapy to be the ideal treatment for Ebola and perhaps a boost for most all infections.

Sierra Leone! Realizing the potential of my life’s work in oxidation, I

decided to go to Africa in the midst of an epidemic of the most vicious virus the world has ever seen.

! I recruited Howard Robins, DPM who pioneered simple direct intravenous (DIV) gas.

! He refused at first, scared to death. However, when it was clear I was going regardless, he said, “I am coming with you. I can’t let you get all the credit!”

! We became blood brothers on the Ebola battlefield!

Active Streets in presence of Ebola. Imagine if it happened here

Now compare to America with coronavirus

Signs Everywhere

Teaching DIV at Sierra Leone Ebola Treatment Center 10-14

Visiting President Koroma

RAPID RESOLUTION OF HEMORRHAGIC FEVER (EBOLA) IN SIERRA LEONE WITH OZONE THERAPY

Rowen, Robins, et al., Afr. J. Infect. Dis. (2016) 10 (1): 49– 54

! Summary: Three of three lab test confirmed cases, one symptomatic case with Ebola needle stick contamination, and the symptomatic consort of the country’s senior physician (who died of Ebola the night before) were treated by the Rowen-Robins method of DIV ozone and nutritional supplements.

! All 5 cleared their symptoms within 48-72 hours, and had no deterioration after the first treatment.

! The death rate was 60% at this time.! Odds of this result by chance – about 1%, and much less considering effectively instant

improvement. ! Ebola mortality fell at Hastings treatment center from 60% (on my arrival there) to about

25% weeks later. No one knows “why”.! Dr. K was refused permission to treat with DIV ozone. However, I learned that in “giving

thanks” to his cure, he secretly spirited in ozone water to give to the patients.

Explanation for the Rapid Effects!Ozone enhances oxygen delivery.!Ozone improves blood rheology and modulates

NO.!Ozone modulates the immune system and

cytokines (TNF alpha).!Ozone inactivates viruses on contact.!Ozone induces production of gamma interferon.!Ozone enhances/modulates immune cells. !It is SAFE! Hence, it may be the IDEAL

treatment for ebola, coronavirus, and other viral infections.

Direct Intravenous Gas (Ozone) Injection

!Dangerous? Controversial?!I’ve done it since 1986. Oxygen is a

metabolically active gas. It is not air, it is not nitrogen. It is quickly metabolized.

!I just want to show that direct IV injections of gas have been going on for decades…….

Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease. Prostaglandins LeukotEssent Fatty Acids. 2001 Oct;65(4):211-4.

! Oxygen infusion is used in complementary medicine for treatment of peripheral occlusive arterial disease.

! Previously Unknown mechanism of action! The mechanism of action is unknown. ! We demonstrate a shift of the prostacyclin/thromboxane ratio

towards prostacyclin by IV O2 gas.! We provide a mechanism of action of IV O2 gas.

Robert Jay Rowen, MD ©

European Studies on Direct Intravenous Oxygen Gas

Impact of intravenous oxygen therapy on the expression of reticulocyte-type 15-lipoxygenase in human volunteers Prostaglandins, Leukotrienes and Essential Fatty Acids Volume 71, Issue 5 , November 2004, Pages 271-276

Robert Jay Rowen, MD ©

Intravenous infusion of oxygen gas has been used in complementary medicine since its introduction in 1954 as therapeutic approach for the treatment of inflammatory disorders with unclear genesis and for the therapy of peripheral occlusive arterial diseases [1 and 2]. Although a number of uncontrolled studies and case reports suggest the beneficial character of intravenous oxygen infusion [3, 4 and 5] no large-scale clinical study is available at the moment. One reason for the lack of controlled clinical studies is the fact that the mechanism of action of this therapeutic approach has not been investigated so far. Only recently it has been shown that intravenous oxygen infusion increases the prostacyclin/thromboxane ratio in patients with peripheral occlusive arterial diseases and thus, may improve peripheral blood flow [5]. For inflammatory disorders it has been suggested that a change in the functionality of eosinopils, the number of which are usually increased during the time-course of classical intravenous oxygen therapy [6], may contribute to the anti-inflammatory effects [7]. Interestingly, the therapeutic effects of intravenous oxygen infusion are particularly evident in eosinophils-related diseases like asthma, psoriasis and atopic eczema. For a long time eosinophils have been considered pro-inflammatory cells, but there appears to be a recent modification of this paradigm [8 and 9]. In fact, eosinophils may act as anti-inflammatory cells, which counteract the pro-inflammatory activities of granulocytes and other classical pro-inflammatory leukocytes.

Robert Jay Rowen, MD ©

We found that 15-lipoxygenase 1 expression and the eosinophil count were significantly increased during the treatment period but returned to normal after the therapy was stopped. There was a striking correlation between the relative number of 15-lipoxygenase transcripts and the eosinophil counts suggesting eosinophils as major source of 15-lipoxygenase 1 expression. Since 15-lipoxygenase has been implicated in the resolving phase of acute inflammatory diseases the anti-inflammatory effects of intravenous oxygen infusion may be explained at least in part by our experimental findings.

Note - I have found PROFOUND elevations of eosinophils after HBO3.

Robert Jay Rowen, MD ©

The infused amount of oxygen gas was linearly increased during the time course of oxygen therapy starting with 15 to 50 ml/day for males and 10 to 40 ml/day for females. The infusion rate was 1–2 ml/min for both genders. [This is nearly identical to the predicted volume amount dissolved gases you will see shortly with HBO3]

[Regelsberger's intravenous oxygen therapy--an interpretation of results in practice from a biochemical and physiological point of view].

! improvement in oxygen availability,

! eosinophilia, which can be valued as an increase in undetermined cellular immunological resistance.

! Improved rheological qualities of the blood

! Diuresis improved

! Release of oxygen into the tissue is increased

! Blood pH is normalized.

! Compared with hyperbaric oxygen therapy, i.v. oxygen therapy seems to have less side effects. Application is less complicated, less expensive but probably of higher efficacy. (This statement does not apply to issues related to diving medicine.)

! Forsch Komplementarmed Klass Naturheilkd. 2002 Feb;9(1):7-18.

Influenzal Pneumonia (IV H2O2)Lancet 2-21-1920, Oliver, et.al.

! IV H2O2 can be given intravenously without oxygen gas embolism

! The anoxemia can be markedly benefited! The toxemia appears to be overcome in many instances.! The mortality (40%) compares very favorably with the

80% death rate in similar cases not so treated and “more so when it is remembered that we treated the most severe and apparently hopeless.”

Finally - UBI

!Ozone’s sister oxidation therapy with stunning roots in America’s medical past.

Finally - UBI

Miley and Christensen, Archives of Physical Therapy, November, 1944, pp. 651-656.

!Int J Biosocial Med Research, Vol. 14(2), 115-132, 1996. 1044-

!Ultraviolet Blood Irradiation Therapy (Photo-Oxidation) The Cure That Time Forgot

!Robert Jay Rowen, MD!This article summarizes most all of the

relevant American literature

One of the Last Remaining Knott Machines on Earth

Ozone Therapy as Seen by:

!Silvia Menendez, PhD - Cuba!Velio Bocci, MD - Italy!Robert Rowen, MD – USA

!Again, with thanks to both researchers for their generous gift to me of slides for teaching purposes.

Medical Ozone can be administered:! In blood directly as gas, or

dissolved in blood (preferred)

! Subcutaneous & soft tissue! IM! Rectal! Vaginal! In bladder! Intradermal! Topical gas! Joints, connective tissue

! Intra peritoneal! Ozone water (ingested

drink, wounds, orifices)! Ear insufflation! Intravenous! Intraarterial! Intra pleural! CSF (as per pediatrician Mayer)

! Ozonized oils topical, rectal oral and vaginal

Ozone can be given most any way to the body, including teeth, with one exception – the lungs

2,3 DGP is required to release oxygen from the RBC. What good is total oxygen saturation of your red cells if they won’t release the cargo to the tissues? It would be analogous to ordering cement for your driveway. The truck comes but doesn’t release its payload before leaving.

Summary of Revitalization Effects - Bocci

1. Activation of immunocompetent cells2. Activation of RBC metabolism and improved O2 release. Increases NAD+ This is the rate limiting step in RBC glycolysis. Prolonged treatment may result in supergifted RBCs generated in the bone marrow, according to Bocci. Ozone improvement reportedly lasts 4 months (the life of RBCs).3. Activation of enzymatic antioxidant status4. Ozone increases plasma protein thiol groups.5. Increases plasma and tissue H2O26. Increases nitric oxide levels.7. Induction of synthesis of potent cytokines and interferons which modulate immune system and stimulate regeneration of tissue, such as TGFB-1. 8.Modulates NO production. NO is necessary but excess is toxic.

Autoimmune Disease - DermatomyositisOctober 17, 2013: methotrexate, Immuran, Prednisone 80 mg, PlaquenilLabs (CPK, ESR, etc. way off the scale.

July 27, 2015. No drugs. Only having had several ozone treatments and infected teeth removed. All labs normal.

His CPK peaked at over 9000 and he was pushed to 120mg prednisone. Autoimmunity Highlights Autoimmunity Highlights (2018) 9:7

Just Published

!A Plausible "Penny" Costing Effective Treatment for Corona Virus - Ozone Therapy

! Journal of Infectious Diseases and Epidemiology! ISSN: 2474-3658! J Infect Dis Epidemiol! Abbrevation: JIDE! DOI: 10.23937/2474-3658/1510113! Pub Date: March 06, 2020

Italy! From: Gaspari Orbisphera <antonio.gaspari@orbisphera.org>! Subject: Re: OZONE THERAPY! Date: March 31, 2020 at 6:45:58 AM EDT! To: Harry Herman <harryherman@me.com

Dear Harry Hermancurrently 15 hospitals in Italy are using oxygen ozone therapy with the SIOOT protocol to treat people with covid - 19.We will communicate the first results already this weekend.Informally, I can tell you that they were exceptional results, which go far beyond our predictions. [emphasis added]Have Good dayAntonio Gaspari Direttore Direttore Orbisphera

! www.orbisphera.org! antonio.gaspari@orbisphera.orgw.orbisphera.organtonio.gaspari@orbisphera.org

China

!5 confirmed cases treated with ozona!2 critically ill!These two cases responded immediately to

ozone therapy and recovered. !The milder cases had an uneventful

revovery

China results in progress! Ozone Autohemotherapy----A new trial for Novel coronavirus

pneumonia! Patient gender: male, 56 years old. He was sent to hospital due to the

fever symptom. The nucleic acid testing for the Novel coronavirus was positive, PaO2 74.8mmHg, oxygenation index 80.43, SaO2 95%, Chest CT: ground—glass opacity. The patient was a critical patient.

!

! Specialist consultation team decided to use Ozone Autohemotherapy as follows: ozone concentration 30ug/ml, draw 100ml blood from the patient and mix the blood with the ozone, then transfuse the blood into the body. The index after 3 hours, PaO2 99.2mmHg, oxygenation index 132.3, SaO2 98%. The patient felt good, and had a relieved symptom.

!

! After 10 pass of the Ozone Autohemotherapy, PaO2 134mmHg, oxygenation index 462, SaO2 100% (2LPM oxygen flow Nasal Tube in Oxygen Treatment)

! 1 critical patient, received 10 pass Ozone Autohemotherapy treatment. He felt very good, the index improved and recovered.

! 1 critical patient, received 2 pass Ozone Autohemotherapy treatment, and improved to normal patient. Fully recovered.

! 1 normal patient, received 1 pass Ozone Autohemotherapy treatment. Fully recovered.

! 1 normal patient, received 1 pass Ozone Autohemotherapy treatment. Fully recovered.

! The above information was provided by Dr. Shi Kemeifrom the second hospital of Tianjin medical university, Tianjin, China who trained the medical staff of Tianjin Haihe Hospital . For more information, please contact:

Peter.li1998@hotmail.com

Ebola Article Third Author

!African, on trip to Germany contracts COVID and has symptoms.

!Receives a single ozone treatment and all symptoms are gone in 4 hours and he is able to return to Sierra Leone.

Ozone challenges!1. Ozone is currently regarded by the FDA

as a toxic gas with no medical uses despite the presence of a plethora of publications to the contrary, which apparently, the agency has ignored. (However, at least one ozone machine is registered with the FDA for importation.

Ozone Challenges!2. Ozone cannot be patented for profit.

Hence, financing (likely need of $150M for full study to obtain “approval” is highly unlikely. There is no financial gain. Any study funding would have to come from fully altruistic sources. We cannot expect a profit driven Pharma industry to be benevolent, especially with a therapy that could undo billions in sales of chemicals.

Ozone Challenges

!3. Ozone suffers from the “tomato effect”. (Rejection of highly efficacious therapies). Though published as safe and effective, it is rejected by conventional medicine, for the reasons listed herein and medicine’s lockout of anything outside FDA “approval.”

! Goodwin JS, Goodwin JM (1984) The tomato effect. Rejection of highly efficacious therapies. JAMA 251(18):2387–2390

Ozone Challenges

!4. OT suffers from regulatory board challenges. Not being pharmaceutical “standard of care” some physicians have been investigated over their use of OT. The current medical paradigm of only using “approved” therapies handcuffs ozone’s integration into medicine.

Ozone Challenges! 5. “Condemned to Die with No Right to Try.” Hospitals

(and most conventional physicians) will not even consider non-approved (FDA) therapies. In 2018, despite providing several original published reports contained in this review’s references, the author was refused permission to use ozone to treat a terminally ill infected (superbug) airline pilot, already given up to die, by a Texas hospital after the distraught family so requested, and providing liability waiver to protect the hospital. The hospitalist cited “policy” to me. The man died shortly afterwards.

Ozone Challenges!6. DIV has clear advantages in cost, ease of

administration, and medical waste, compatible with ALL other treatments, but can scleroseveins, and cause temporary chest tightness. It may be most suitable in third world countries and for patients who do not have the larger veins required for MAH or HBO3, or in a pandemic where time and resources are scarce. Fast administration time, 2-3 minutes, depending on patient response. Less than $1 in materials.

Beauty of Ozone Therapy

!Very low cost!No profiting off suffering!Extremely safe!Rapidly deployable!Can treat quickly!Can treat many quickly and with one machine!Known and in continuous use for over 100 yrs!Providers can be trained quickly

Dr. Velio Bocci elaborates–

! “It depresses me to think that ozone, the cheapest drug on earth, is today either badly or minimally used because orthodox medicine refuses to evaluate it and Health Authorities are antagonistic or negligent. Both are responsible for leaving millions of people suffering and dying. I must not get discouraged and continue to work and hope that ozone therapy will eventually benefit many people.”

Robert Rowen, MD: “ Ozone offers more good for more medical and health matters than any other thing I’ve seen in my entire career except proper nutrition and detox.”

www.DrRowenDrSu.com707-578-7787

It appears that even the most deadly viruses are quite fragile and if we would exploit this

fragility based on our own innate defenses, we could avoid pain, expense, suffering and

death.Thank you for the honor of your attendance