Oxygen Absorption in Hemoglobin and Brain Activity Measurement · Motivation zA need for...
Transcript of Oxygen Absorption in Hemoglobin and Brain Activity Measurement · Motivation zA need for...
Oxygen Absorption in Hemoglobin and Brain Activity Measurement
Quantitation of Oxygen ConcentrationShakera Guess
Advisor: Dr. Britton Chance Ph. D, Sc. D, M.D
Motivation
Current methods of lie detection– Polygraph
Breathing rate, pulse, blood pressure, perspirationAnxiety Detector
Motivation
Current methods of lie detection– fMRI
Brain mappingCurrently most favorableImmobilizationExpensive
Motivation
A need for non-invasively measuring cognitive function
Current methods of measuring brain function include positron emission tomography (PET imaging) and electroencephalography (EEG).
Background
•Near Infrared Spectroscopy (NIRS)•Many benefits
•Used in a variety of procedures
•700-900 nmLCC HbOHbOHbHbeGII )(
022αα +−=
– Absorption in body contains information about hemoglobin level changes
– Thinking = BV level changes
– Biological tissue transparent 700-900 nm
– NIRS can predict certain thought processes
Background
Project Goals
Different methods of quantitationNIRS and Cognosensor
Oxygen Absorption in Yeast
Oxygen Absorption Measurement in Yeast UsingOxygen Electrode
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Time (min)
Absorption
Yeast
Water
•Results of experiment performed with Clarke Oxygen Electrode, yeast, and water.
•Electrode used to connect with the non-metallic part of a circuit
using equation
O2 + H2O + 2e- → H2O2 + 2OH-
Oxygen Absorption in Hemoglobin
Oxygen Electrode Data 7/19
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Time
Intensity
Intensity•Results of oxygen absorption measurement in hemoglobin performed with Clarke Oxygen Electrode.
Oxygen (Electrode) and Hemoglobin (Brain Probe)Data Merged
-300
-200
-100
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27.7
50.5
53.3
61.1
88.8
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Time
Intensity/Blood
Volume
Oxygen
Hemoglobin (x5)
Further Uses
Early breast cancer detection– Women under 40– High risk– Underserved population
Right Left Right Left
Further Uses
Lie detection– Many ground-
breaking studies– Changes in blood
oxygenation in cortex– Cognitive components
of deception and emotional response
– NIRS used to differentiate
Conclusions
Near Infra-Red Spectroscopy (NIRS) used to measure the change of blood volumes in the brainSimple and cheap handheld device used to non-invasively measure cognitive functionMany uses including lie detection and early breast cancer detection
Acknowledgements
SUNFEST ParticipantsDr. Britton ChanceDr. Van der Spiegel– His office, DeloresSpecial thanks to the
National Science Foundation and the University of Pennsylvania.
Thank You!
Shakera Guess