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Transcript of Osu 2014 asco review savvides pres head & neck
![Page 1: Osu 2014 asco review savvides pres head & neck](https://reader034.fdocuments.net/reader034/viewer/2022052618/54985b25ac795925288b5784/html5/thumbnails/1.jpg)
ASCO Review: H&N Cancer
Panos Savvides, MD PhD MPH
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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute 2
ASCO 2014 Review: What’s new in H&N?
Results of SELECT, a lenvatinib phase III clinical trial in Radioactive Iodine Refractory Thyroid Cancer: A new treatment standard? Role of induction chemotherapy in locally advanced
head and neck cancer Italian Induction phase III clinical trial Induction in Nasopharyngeal cancer Treatment de-intensification in Oropharyngeal Cancer
Predictive and prognostic markers to therapy Cetuximab and HPV
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A phase 3, multicenter, randomized, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with 131I-refractory differentiated thyroid cancer (SELECT)
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Slide 17
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Study Rationale
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Study 303: Study Schema
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Patient Characteristics
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Primary Endpoint:<br />Kaplan-Meier Estimate of PFS
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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PFS by Previous VEGF-Targeted Therapy
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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PFS Subgroup Analyses
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Response Rates
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Best Tumor Response
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Overall Survival, ITT population
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Study Medication Exposure
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Treatment-emergent Adverse Events (TEAEs)
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Most Frequent Treatment-related Adverse Events (> 20%)
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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TEAEs of Special Interest
Presented By Martin Schlumberger at 2014 ASCO Annual Meeting
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Clinical trial comparison DECIDE v SELECT
Presented By A. Colevas at 2014 ASCO Annual Meeting
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tumor reduction
Presented By A. Colevas at 2014 ASCO Annual Meeting
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Primary endpoint: PFS
Presented By A. Colevas at 2014 ASCO Annual Meeting
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Survival: Neither sorafenib nor lenvatinib improve survival in these trials
Presented By A. Colevas at 2014 ASCO Annual Meeting
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Toxicity and dosing issues
Presented By A. Colevas at 2014 ASCO Annual Meeting
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Lingering questions
Presented By A. Colevas at 2014 ASCO Annual Meeting
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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute 24
ASCO 2014 Review: What’s new in H&N?
Results of SELECT, a lenvatinib phase III clinical trial in Radioactive Iodine Refractory Thyroid Cancer: A new treatment standard? Role of induction chemotherapy in locally
advanced head and neck cancer Italian Induction phase III clinical trial Induction in Nasopharyngeal cancer Treatment de-intensification in Oropharyngeal Cancer
Predictive and prognostic markers to therapy Cetuximab and HPV
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History of Induction Chemotherapy
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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ICT vs. CRT
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute 27
ASCO 2014 Review: What’s new in H&N?
Results of SELECT, a lenvatinib phase III clinical trial in Radioactive Iodine Refractory Thyroid Cancer: A new treatment standard? Role of induction chemotherapy in locally
advanced head and neck cancer Italian Induction phase III clinical trial Induction in Nasopharyngeal cancer Treatment de-intensification in Oropharyngeal Cancer
Predictive and prognostic markers to therapy Cetuximab and HPV
![Page 28: Osu 2014 asco review savvides pres head & neck](https://reader034.fdocuments.net/reader034/viewer/2022052618/54985b25ac795925288b5784/html5/thumbnails/28.jpg)
Slide 7
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Slide 8
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Slide 9
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Trial Comparison
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Slide 11
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Slide 12
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Questions Pertained to the Italian Study
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Overall Survival based on RT quality/volume
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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What can we conclude about ICT?
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute 37
ASCO 2014 Review: What’s new in H&N?
Results of SELECT, a lenvatinib phase III clinical trial in Radioactive Iodine Refractory Thyroid Cancer: A new treatment standard? Role of induction chemotherapy in locally advanced
head and neck cancer Italian Induction phase III clinical trial Induction in Nasopharyngeal cancer Treatment de-intensification in Oropharyngeal Cancer
Predictive and prognostic markers to therapy Cetuximab and HPV
![Page 38: Osu 2014 asco review savvides pres head & neck](https://reader034.fdocuments.net/reader034/viewer/2022052618/54985b25ac795925288b5784/html5/thumbnails/38.jpg)
Chemotherapy in NPC
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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NCCS Trial Treatment Schema
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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NCCS Outcomes
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Why is NCCS Trial Negative
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute 42
ASCO 2014 Review: What’s new in H&N?
Results of SELECT, a lenvatinib phase III clinical trial in Radioactive Iodine Refractory Thyroid Cancer: A new treatment standard? Role of induction chemotherapy in locally advanced
head and neck cancer Italian Induction phase III clinical trial Induction in Nasopharyngeal cancer Treatment de-intensification in Oropharyngeal
Cancer Predictive and prognostic markers to therapy Cetuximab and HPV
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Risk Group Definition base on HPV, Tobacco use & T/N status – Possible role for dose de-escalation in a patient subgroup
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Slide 28
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Results of E1308
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Endpoint: 2yr PFS and OS
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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Questions to address in good risk HPV+ patients
Presented By Quynh-Thu Le at 2014 ASCO Annual Meeting
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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute 48
ASCO 2014 Review: What’s new in H&N?
Results of SELECT, a lenvatinib phase III clinical trial in Radioactive Iodine Refractory Thyroid Cancer: A new treatment standard? Role of induction chemotherapy in locally advanced
head and neck cancer Italian Induction phase III clinical trial Induction in Nasopharyngeal cancer Treatment de-intensification in Oropharyngeal Cancer
Predictive and prognostic markers to therapy Cetuximab and HPV
![Page 49: Osu 2014 asco review savvides pres head & neck](https://reader034.fdocuments.net/reader034/viewer/2022052618/54985b25ac795925288b5784/html5/thumbnails/49.jpg)
Biomarkers
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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HPV and cetuximab
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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Cetuximab + Chemotherapy in SCCHN
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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SPECTRUM: OS and PFS by arm and p16
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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RT + cetuximab significantly improves LRC and 5-year OS
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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Slide 10
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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Slide 11
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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Interactions between HPV and the EGFR signaling pathway
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting
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Slide 14
Presented By Vassiliki Papadimitrakopoulou at 2014 ASCO Annual Meeting