Osteoarthritis Typically affects the fingers, spine, hips and knees.
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Transcript of Osteoarthritis Typically affects the fingers, spine, hips and knees.
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Osteoarthritis
• Typically affects the fingers, spine, hips and knees
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BYBY
INT. KAMOLWANINT. KAMOLWAN
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OA KNEE
• Chronic, degenerative disorder of multifactorial aetiology, characterised by loss of articular cartilage and periarticular bone remodelling, particularly large weight-bearing joints
• Common in older patients but can occur in younger patients ( genetic mechanism , previous joint trauma )
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Pathophysiology
• Degenerative alterations primarily begin in the articular cartilage
• External forces accelerate the catabolic effects of the chondrocytes and disrupt the cartilaginous matrix
• Enzymatic destruction increases cartilage degradation ↓ proteoglycans and collagen synthesis
• Decreased strength of the cartilage is compounded by adverse alterations of the collagen
• Reduced contact area of the cartilage
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Pathophysiology
• Loss of cartilage results in the loss of the joint space
• Progressive erosion of the damaged cartilage occurs until the underlying bone is exposed
• Subchondral bone responds with vascular invasion and increased cellularity, at areas of pressure
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Pathophysiology
• The traumatized subchondral bone may undergo cystic degeneration
• At nonpressure areas along the articular margin → irregular outgrowth of new bone (osteophytes)
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• Normal joint• hinge joint formed
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• Surface layer of cartilage break down and wears away,causes the bones under the cartilage to rub together
• Pain, swelling, and loss of motion result
• formation of bone spurs
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Incidence
• Incidence increases with age
• USA approximately 80-90% of individuals older than 65 years have evidence of primary osteoarthritis
• After age 55 years, the prevalence increases in women in comparison with men
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Incidence
• Equivalent prevalence occurs in men and women aged 45-55 years (↑dramatically after the age of 50 years)
• Most adults older than 55 years show radiographic evidence of osteoarthritis
• No significant correlation exists between incidence of OA and race
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Causes
Primary OA
• Idiopathic
• Defective gene
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Causes
Secondary OA – Obesity – Repetitive use (ie, jobs requiring heavy labor
and bending)– Previous trauma (ie, posttraumatic OA)– Infection
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Causes
– Crystal deposition– Acromegaly– Previous rheumatoid arthritis (ie, burnt-out
rheumatoid arthritis)– Heritable metabolic causes (eg, alkaptonuria,
hemochromatosis, Wilson disease)
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Causes
– Hemoglobinopathies (eg, sickle cell disease, thalassemia)
– Underlying orthopedic disorders (eg, congenital hip dislocation, slipped femoral capital epiphysis)
– Disorders of bone (eg, Paget disease, avascular necrosis)
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History
• Insidious throbbing arthralgias with activity
• Initially, resting relieves the pain
• Eventually, the pain occurs even at rest
• Morning stiffness ≥ 30 minutes
• Intermittent joint swelling
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Symptoms
• Pain
• Stiffness
• Gelling
• Instability
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Signs
• Pain
• Tenderness
• Swelling
• Effusion
• Crepitus
• Limitation of movement and muscle wasting
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Physical
• Early– Joints may appear normal– Gait may be antalgic if weight-bearing joints
are involved
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Physical
• Later – Visible osteophytes may be noted– Joints may be warm to palpation– Palpable osteophytes frequently are noted– Joint effusion frequently is evidenced in
superficial joints
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Physical
– Range-of-motion limitations, because of bony restrictions and/or soft tissue contractures, are characteristic
– Crepitus with range of motion is not uncommon
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Imaging
• Plain radiographs
• Bone scans may be helpful in early diagnosis of OA of the hand
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• The space between the bones of the upper and lower leg is smaller
• Bony spurs (osteophytes)
• Increase bone density at the margin of the joint
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- x ray findings
– Joint space narrowing
– Osteophytes– Subchondral sclerosis : ↑ bone density, fre
quently found adjacent to joint space
– Subchondral cysts : fluid-filled sacs which extrude from the joint
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Diagnosis
• On the basis of the initial history and examination
• X-rays
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PROGRESS
• Osteoarthritis begins when the joint cartilage starts to become worn down → decreases the ability of the cartilage to work as a shock-absorber to reduce the impact of stress on the joints
• The remaining cartilage wears down faster→ bones to grind against one another
• Bone spurs may form
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Treatment
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Goals of managing OA
• Controlling pain
• Maintaining and improving the range of movement and stability of affected joints
• Limiting functional impairment
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Treatment
• Education and behavioural intervention- Aim is to provide patients with an
understanding of the disease process, its prognosis and the rationale and implications of managing their condition
• Weight loss - Weight loss (< 5 kg) has significant short-
term and long-term reduction in symptoms of OA
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Treatment
• Mechanical aids
- Wear shock-absorbing footwear with good mediolateral support, adequate arch support and calcaneal cushion
• Exercise - Aim of exercise is to reduce pain and disability
by strengthening muscle, improving joint stability, increasing the range of movement and improving aerobic fitness
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Treatment
• Medication
- Acetaminophen (Tylenol®) is a mild pain reliever with few side effects
- Anti-inflammatory medication, such as ibuprofen and aspirin
- COX-2 inhibitors
- Glucosamine and Chondroitin sulfate
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Treatment
• Intra-articular injection
- Glucocorticoids injection
- Hyaluronic Acid (HA) and similar
hyaluronan preparations (eg, Synvisc)
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Treatment
• Surgery
- Arthroscopy (including debridement,and lavage/irrigation)
- Proximal Tibial Osteotomy
- Artificial Knee Replacement
- Osteotomy
- Arthroplasty or Joint Replacement