Osseolive® Dental Bone Graft

This unique new osteobiologic graft is designed for optimal bone grafting: it works with the body’s natural healing response to stimulate physiologic bone regeneration—without the problems associated with autograft or potential safety risks of allograft.

Osseolive Dental is a new class of biomaterials made from bioactive calcium-potassium-sodium- phosphate, a modified and advanced form of tricalcium phosphate.

Clinical evaluations have shown excellent bone remodeling with favorable outcomes in implantology and sinus lifts among other indications.

When time matters, it's time for Osseolive.

Resorption and Remodeling Osseolive Dental is an osteobiologic that provides rapid resorption and remodeling, as demonstrated in this pre-clinical sheep scapula model. 1

Fig. 1. Osseolive particle and particle fragment at 2 weeks showing excellent bone formation at their surface (white arrows). In addition, strong osteocalcin expression of the mineralized bone matrix is present (short yellow arrows). Also beginning particle degradation is visible with new bone formation in these areas (black arrows). The considerable extent of new bone formation after two weeks demonstrates the excellent bioactivity of this material as well as its enhanced stimulatory effect on bone formation.

Fig. 2. Critical-size defect 1 month after implantation of Osseolive. Extensive woven bone formation has occurred filling the majority of the defect. Osseolive particles exhibit excellent bone-particle contact (white arrows). In addition, strong osteocalcin expression of the mineral-ized bone matrix is present (short yellow arrows), indicating that matrix mineralization is actively progressing in these areas.

Fig. 1

Fig. 2

T = 0

photo courtesy: Dr. Robert Miller

T = 2 months Implant placement T = 2 months

About curasanAn innovative developer, manufacturer and marketer of biomaterials for bone and tissue

regeneration, curasan focuses on the world-wide dental, orthopedic and spine markets.

Numerous patents and a comprehensive and expanding list of scientific studies demonstrate

the clinical success of the innovative curasan product portfolio.

ph: 919.941.9770www.curasan.com

LIT 500-22 Rev A 7/2019

1 Knabe, et al; Effect of Silicon-Doped Calcium Phosphate Bone Substitutes on Bone Formation and Osteoblastic Phenotype Expression In Vivo, Key Engineering Materials, 2014, Vol 614, pp 31-34 2 Knabe, C., Ducheyne, P., Adel-Khattab, D., and Stiller, M. (2017) 7.20 Dental Graft Materials. In: Ducheyne, P., Grainger, D.W., Healy, K.E., Hutmacher, D.W., and Kirkpatrick, C.J. (eds.), Comprehensive Biomaterials II, vol. 7, pp. 378–405. Oxford: Elsevier.

Item Number Description Granule Size Volume Unit PkgL05-V0250 Osseolive Granule 250-1000µm 0.5cc 1 vial/pk

L10-V0250 Osseolive Granule 250-1000µm 1.0cc 1 vial/pk

L20-V0250 Osseolive Granule 250-1000µm 2.0cc 1 vial/pk

L05-M0250 Osseolive Granule 250-1000µm 0.5cc 5 vials/pk

L10-M0250 Osseolive Granule 250-1000µm 1.0cc 5 vials/pk

L20-M0250 Osseolive Granule 250-1000µm 2.0cc 5 vials/pk

L05-V1000 Osseolive Granule 1000-2000µm 0.5cc 1 vial/pk

L10-V1000 Osseolive Granule 1000-2000µm 1.0cc 1 vial/pk

L20-V1000 Osseolive Granule 1000-2000µm 2.0cc 1 vial/pk

L05-M1000 Osseolive Granule 1000-2000µm 0.5cc 5 vials/pk

L10-M1000 Osseolive Granule 1000-2000µm 1.0cc 5 vials/pk

L20-M1000 Osseolive Granule 1000-2000µm 2.0cc 5 vials/pk

Innovation that Delivers Osteobiologic Solutions.

Results Count2 In a thirty-eight patient sinus lift study, Osseolive "showed excellent bone formation in the sinus floor and that the bone graft had been mostly replaced by newly formed bone at six months.Excellent formation of cancellous bone in the sinus floor with few residual highly degraded Ossseolive particle fragments embedded in the newly formed bone.”

(d–g) histomicrographs of deacrylated sawed section stained immunohistochemically for osteocalcin (yellow arrows – residual ceramic particle fragments embedded in newly formed bone, green arrows – osteogenic mes-enchym with strong osteocalcin expression, black arrows – bone formation at the surface and within the residual degrading calcium alkali orthophosphate particles, which is indicative of the excellent bone bonding behavior of this material as well as of its ability to induce bone for-mation at its surface, ie, its excellent bioactivity

( f )

(g) (h)