Optimizing pre-hospital triage and transfer pathways for ... pre... · Optimizing pre-hospital...

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1 Stroke Unit. Neurology Dpt. Hospital Universitari Vall d’Hebron. Barcelona. Optimizing pre-hospital triage and transfer pathways for LVO stroke - lessons from RACECAT Marc Ribo Stroke Option A Option B Uchino K, for the CLOTBUST Collaborators ISC 2003 11% 0.22 0.07-0.76 29% 0.71 0.41-1.2 44 % 2.12 1.21-3.71 Prob. OR 95% IC n=250 TIBI 1 TIBI 5 + 1 hour iv-tPA

Transcript of Optimizing pre-hospital triage and transfer pathways for ... pre... · Optimizing pre-hospital...

Page 1: Optimizing pre-hospital triage and transfer pathways for ... pre... · Optimizing pre-hospital triage and transfer pathways for LVO stroke -lessons from RACECAT Marc Ribo Stroke OptionA

1Stroke Unit. Neurology Dpt.Hospital Universitari Vall d’Hebron. Barcelona.

Optimizing pre-hospital triage and transfer pathways for LVO stroke - lessons from RACECAT

Marc Ribo

Stroke

Option A

Option B

Uchino K, for the CLOTBUST Collaborators ISC 2003

11% 0.22 0.07-0.76

29% 0.71 0.41-1.2

44 % 2.12 1.21-3.71

Prob. OR 95% ICn=250

TIBI 1 TIBI 5

+ 1 houriv-tPA

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Stroke Unit

Stroke Unit

Comprehensive Stroke Centers

Primary Stroke Centers

100 Pre-Hospital Acute Stroke Codes

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Mimic

Ischemic LVO-

Ischemic LVO+

ICH

100 Pre-Hospital Acute Stroke Codes

Comprehensive StrokeCenter

PrimaryStroke Center

Expert StrokeNeurologist

Geo- location

Remote assessment

Stroke Mimic

Ischemic LVO-

Ischemic LVO+

ICH

Mimic

Ischemic LVO-

Ischemic LVO+

ICH

100 Pre-Hospital Acute Stroke Codes

Perfect Screen

16 minutesreduction

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Probability of Large Vessel Occlusion

TRIAGE

Mimic

Ischemic LVO-

Ischemic LVO+

ICH

100 Pre-Hospital Acute Stroke Codes

Perfect Screen

60%Ischemic tPA+

LVO+LVO-ICHMimic

35%Ischemic

LVO+iv-tPA EVT

iv-tPA

EVT

Option A

Shortcut

Case 1

iv-tPA EVT

iv-tPA

EVT

Option A

Shortcut

Recanalization

Case 2

iv-tPA EVT

iv-tPA

EVT

Option A

Shortcut

No LVO

Case 3

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iv-tPA

EVT

DIDO

60

EVT

OOODIDODIDODIDODIDO

606060

Stroke Unit

Stroke UnitThe Catalan Stroke Registry

Stroke Codes

Ischemic

Iv-tPA

EVT

Primary EVT

Iv-tPA + EVT

Only iv-tPA

Stroke code AlertsInitial Transfer

Town of initial alert

11.000

PSC

CSC

No stroke ready

Secondary transfers for EVT11.000TransfersTransfers

Transfer TimeEVT / No EVT

ASPECTS at PSCNIHSS at PSC

ASPECTS at CSCNIHSS at ISC

LVO */-

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ASPE

CTS

at P

SC

NIHS

S at

PSC

ASPECTS at CSC after transfer

0-5 6-10

Clinical and Neuroimaging Criteria to Improve Transfers to Comprehensive Stroke Centers

for Endovascular Treatment evaluation Rubiera M.ISC 2019, Hawaii

2016

2017

2018

# EVT / #STROKE CODE ACTIVATED(per regions)

Geographical spread of EVT

Increase in absolute number of SC

Increase in absolute number of EVT

Uneaven activation of stroke codes

1

2

Stroke Code activation by EMS1: too rare2: too selective

Barcelona

iv-tPA treatmentsAccording to onset location

EVTAccording to onset location

Town of initial alert

In specific áreas: Better Access to iv-tPA than to EVT

Iv-tPA

EVT

Stroke

Option A

Option B

Stroke

Option A Vs Option B ?

ENDPOINTS:

Option A Vs Option B ?

A B

CVs

CCSECONDARY ENDPOINTS:

Safety / efficacy: according to distance, time from onset

Safety /efficacy in ischemic / hemorrhagic strokes

% patients receiving iv-TPA /EVT

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Interim analysis

Interim analysis

Interim analysis

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

Expected

Found

RACE SCALE SCORES DISTRIBUTION AT INCLUSION

RACE 5 RACE 6 RACE 7 RACE 8 RACE 9

Median NIHSS at firsthospital:

17 (12-21)

Administrative and Safety Analysis 700*

43

45.4

21

18.5 4.7

28

24

8

7.4

0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

Expected

Found

Diagnostic at Hospital Arrival

LVO No LVO LVO ? ICH Mimic

43 21Expected

Expected EVT%: Group A: 12%Group B: 35%

Expected EVT%: Group A: 12%Group B: 35%

average 23.5%

Administrative and Safety Analysis n=700*

29.63% of all patients

Found43.2% of all ischemicEVT