Optimize your lif e. - HGH · Optimize your lif e. ... This therapy involves Human Growth Hormone...

LONGEVITY GUIDE TO

2 0 0 7

w w w . o p t i m a l h e a l t h m d . c o m

Optimal Health & Rejuvenation Center, LLC © 2007

Optimize your l i fe. ®

Call Optimal Health:

1-877-224-3633www. o p t im a l h e a l t hm d . c om


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INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .I

DO YOU NEED THERAPY? . . . . . . . . . . . . . . . . . . . . . . . . .1

HORMONE REPLACEMENT Q & A’S . . . . . . . . . . . . . . . .2-3

GETTING STARTED . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .5

HUMAN GROWTH HORMONE - HGH . . . . . . . .SECTION II

INTRODUCTION TO HGH . . . . . . . . . . . . . . . . . . . . . . . . . .9

ANTI-AGING BENEFITS . . . . . . . . . . . . . . . . . . . . . . . . . . .10

DYNAMICS OF HGH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11

BENEFITS VS. RISKS . . . . . . . . . . . . . . . . . . . . . . . . . . . . .12

STAYINGYOUNG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13

HEALTHY LIVING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14

TESTOSTERONE . . . . . . . . . . . . . . . . . . . . . . . .SECTION III

INTRODUCTION TO TESTOSTERONE . . . . . . . . . . . . . . . . .17

DEFICIENCIES & BENEFITS . . . . . . . . . . . . . . . . . . . . . . .18

DIAGNOSIS & TREATMENT . . . . . . . . . . . . . . . . . . . . . . . .19-20

TESTOSTERONE PROGRAMS . . . . . . . . . . . . . . . . . . . . . .21

ANCILLARY SUPPLEMENTS . . . . . . . . . . . . . . . . . . . . . .22

ORDER FORMS . . . . . . . . . . . . . . . . . . . . . . . . .SECTION IV

Welcome to Optimal Health & Rejuvenation Center, LLC. - We specialize in age management

programs that focus on preventive medicine as a means to reduce the negative effects of aging.

Our programs are a result of extensive medical research and advances in biotechnology, which

have allowed us to combine both mainstream and alternative medical treatments in an effort

to provide individuals with the benefits of a vibrant lifestyle and extended lifespan.

Optimal Health combines several medical specialties that involve nutrition profiling, body

chemistry, conditioning and hormone modulation, which deals with the endocrine system as key

factor in optimal hormone balance.This guide will help you understand the importance of such

hormones like: Human Growth Hormone, Estrogen, Testosterone, Melatonin and DHEA, that

decline as we get older beyond 35 years of age. Right now you may already be experiencing

many of chronic deficiencies that are a direct cause of premature aging, many are caused by a

hormone deficiency or nutritional imbalance. Do you feel tired more often or forgetful, easily

stressed or anxious, sudden weight gain, muscle loss and a diminish appearance or physique. All

of the mentioned conditions have a direct impact in your lifestyle; they can lead to poor job

performance, low self-esteem, lack of ambition and diminishing sex drive.

Through our network of specialist and trained counselors, we can provide you with a safe and

effective way to enter a medically supervised program that is specifically designed to deliver

the optimal result you desire.We will be with you every step of the way, providing you with the

guidance and advice to provide you with an exceptional outcome.

After reading this guide you may have questions and we are here to provide you with answers.

We know you will be eager to start on the path to a healthy and vibrant lifestyle, please call us

with any questions you may have and one of our counselors will assist you.

To get started, call us at: 1-877-224-3633

specialist

Optimize your l i fe.


What if we told you that Optimal Health has the power to reverse symptoms associatedwith the aging process and has the ability to make you feel, look, perform and live better,what would you think?

Optimal Health has successfully treated thousands of patients with hormone replacementtherapy, primarily focusing on medically supervised Human Growth Hormone (HGH) andTestosterone Replacement Programs.

Right now, it is very likely your levels of Human Growth Hormone andTestosterone are notat their optimal level. Take this simple quiz to see if you are a candidate for HormonalReplacement Therapy (HRT):

Do you have a decrease in libido (sex drive)? Yes No

Do you have a lack of energy and motivation? Yes No

Do you have a decrease in strength and endurance? Yes No

Have you developed love handles or a “spare tire”? Yes No

Are you losing your figure and muscle tone? Yes No

Have you noticed a decrease in enjoyment of life? Yes No

Do you have a tendency to be sad and grouchy? Yes No

Do you easily tire in the afternoon or after meals? Yes No

Do you find yourself being forgetful? Yes No

Do you have a lack of drive and ambition? Yes No

If you have answered yyeess to at least half of these questions, chances are, you may alreadyhave low to moderately low levels of either Human Growth Hormone or Testosterone.

Fortunately, there is something Optimal Health can do to help. Through one of our programs we can elevate your levels to the optimal ranges you may have enjoyed in youryounger years.

How do you know if you need therapy?

[ ]1Optimal Health & Rejuvenation Center, LLC © 2007

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What is HRT?Hormone Replacement Therapy (HRT) is a proven and effective process in which hormone levels are brought backto normal levels. Good levels will help maintain your energy levels, healthy mood, increased fertility and sexualdesire. This therapy involves Human Growth Hormone (HGH) and Testosterone. HGH is the largest proteinproduced by the pituitary gland which is made up of 191 amino acids . HGH is genetically engineered of thesame 191 amino acids. It is the same genetic engineering used for insulin. Cloning the identical sequence of theDNA for that of HGH makes it physically, chemically and biologically identical to the one made naturally bythe pituitary gland. Testosterone is the Androgenic Hormone primarily responsible for normal growth anddevelopment of the male sex and reproductive organs. It facilitates the development of secondary male sexcharacteristics such as musculature, bone mass, fat distribution, hair patterns, and vocal chord thickening.

How are the hormones replaced?Testosterone is replaced using either weekly subcutaneous (under the skin) injections or a specially formulatedtransdermal topical gel. The gel is typically applied to the surface of the skin in the morning and HGH isadministered by daily injection. The Optimal Health Doctors and Medically Trained Counselors will explain theeasy and painless process.

Is it safe?Yes! There are numerous studies that have come out over the past years that have attested to the safety ofnatural hormone replacement.

Does it work?Yes! This is not a fanciful search for the fountain of youth. It is medical science at its best. Over the years therehave been thousands of case studies and medical trials that provide absolute, conclusive evidence that hormonetherapy works and has many benefits that result in better health, energy and sexuality. Board CertifiedPhysicians using sophisticated lab tests and treatment protocols make possible these favorable, life-alteringresults.

When should I think about replacing hormones?The typical person’s hormones start to decline by the mid to late 20’s. By age 35 declines are sufficient thatsymptoms may be evident. A great time to start replacing hormones is between the ages of 35 and 55. However,it is never too late. We have people in their 80's that have found a new life through HRT.

Do you recommend replacing both HGH and Testosterone at the same time?Hormones may be replaced separately or in any combination. Better results are obtained from taking a combinationof hormones. We like to say there is a “1+1=3” relationship - since the results are three times as high when taken inconjunction.

How will I lose weight?HGH re-contours the body, changing your body composition to reduce the fat and increase lean muscle mass.It is like a metabolic liposuction, vacuuming out the fat from underneath, particularly throughout theabdominal area. Unfortunately, the more body fat you have in your mid-section, the less HGH your bodyreleases. HGH accelerates the burning of fat by making it available as a “fuel”. By increasing free fatty acids,HGH makes the fat stored available for energy production. This is due to fat cells having HGH receptors thatthe HGH binds to. This triggers a series of enzymatic reactions in the cell to break down the fat. A processcalled “lipolysis”. With HGH you are changing the hormonal message telling your body to get rid of fat. HGHalso increases your overall energy expenditures so that you actually burn calories faster, a great metabolicaftereffect. Unlike other fat-reducing methods which work against the body, HGH works with your body’snatural order to lessen fat and increase muscle.

Hormone Replacement Therapy- Q&A


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How will I build solid muscle?HGH working thru IGF-1 increases the uptake of amino acids in the cell and enhances synthesis of DNAand RNA proteins, extra-cellular proteins, carbs, and sugars. The result is an increase in cell size,accelerating cell division and resulting in accelerated muscle growth. It also builds muscle by conservingthe nitrogen needed for muscle tissue. Ordinarily when you loose weight you excrete nitrogen, but HGHkeeps the body from losing nitrogen. It also increases protein synthesis without increasing the breakdownof proteins in the cell. Accelerated cell division also means speedy healing and repair after injury.

Will Hormone Therapy help sexual dysfunction?Although sexual dysfunction can have many causes; replacing hormones is one of the best places to starttreatment. We suggest raising your testosterone to a healthy level along with growth hormone, to boostyour sex drive. There are many products that increase the amount of nitric oxide in the blood to aid sexualmechanics. Products like Viagra will not assist with the overall sexual function, they temporarily fix themechanics of the problem. Our restorative Hormone Therapy Programs have been found to fix over 90%of problems of sexual dysfunction and will have you eagerly performing at optimum levels. Rarely will therebe a need to supplement our effective programs, but you may safely take additional performancesupplements along with one of our programs.

Will hormone replacement cause my natural hormone production to decline?Cycling of hormones is designed to minimize the possibility of a decline in your natural hormone production. Cycling is taking time off from hormone replacement. When synthetic hormones are introducedinto the body, the gland producing that hormone senses that the body has an adequate supply of thehormone and minimizes production. Cycling is mandatory for HGH and for men under 45 on testosterone.

Are there side effects?If used under a doctor’s care, there is absolutely no evidence suggesting any unfavorable long term sideeffects. If abused, you may develop carpel tunnel syndrome which is inflammation of wrist tendons, waterretention, gynecomastia (testicle shrinkage) or acromegaly (enlargement of the bones).

What about oral HGH or HGH stimulants?It has been medically proven that HGH cannot be absorbed through the digestive system. Advertisementsthat claim they have real HGH in a spray or pill may in fact only contain small amounts of HGH. There issome evidence that HGH can enter the blood stream if absorbed directly into the membranes of the mouth,but oral HGH therapy is not as effective as a medically supervised injectable program.

Do I have to come to the Optimal Health Clinic in Miami Beach?No. We provide nationwide services through our network of affiliates. Within 48 hours of placing yourorder, one of our counselors will call you to arrange for a blood test and a physical exam at an affiliate inyour area or in the privacy of your own home or office.

How do I get started?It is easy. Call us at 11..887777..222244..33663333. Our counselors will guide you through the various programs andhelp you fill out a confidential patient medical history form. This process usually takes no more than 15minutes and can be completed over the telephone. Provided you qualify for treatment, your order will beshipped via FedEx.

What if the doctor does not write a prescription?If your blood work or medical history results disqualify you from treatment, we will refund you 100%within 24 hours.


Although every case has its variations, generally you can expect:

1st Month:Increase in mental sharpness, enthusiasm for life and areduction of mild to moderate depression. Higher levels ofenergy, better results from exercise and weight controlefforts. Better sleep.

2nd Month:Improved muscle tone, enhanced sexual function,improvement in nail growth and skin tone, better digestion,increased strength and weight loss. Improved hair growthand thickening of the hair with shinier and healthierappearance.

3rd Month:Mental processes improve, including desire to do andcomplete projects, increased muscle size (particularlyimproved with exercise routine), hair re-growth, reductionin post menstrual symptoms in women, increased sexualdesire, greater body flexibility.

4th Month:Similar to 3rd Month: Generally, improvements areheightened and are more consistent.

5th Month:Impressive weight loss, reduction of fat and muscle tissueis increased. Toned improvement to skin texture, reducedappearance of wrinkles, vast improvements to hair growth.

6th Month:This is a rather significant stage for women, since cellulitegreatly diminishes, the body becomes more contoured,eyesight is improved, stronger resistance to colds, flu, andother illnesses, chronic pain diminishes, old wounds have atendency to heal, excellent exercise tolerance, grayed hairbegins to return to its natural color. Medical test show areduction in LDL cholesterol and triglycerides, bloodpressure normalizes, heart rate improves, some conditionsdue to disease vanish or are diminished and immune systemimproves.

What type of results can I expect?

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It is easy to get started on an Optimal Health Hormone Replacement Program. We haveset-up a five step plan that is designed to save you time, effort and maximize results.Entering one of our medically supervised programs is a relaxed and carefree process.

Step 1:

Call Optimal Health toll free at 1-877-224-3633. Our Medically Trained Counselorswill assess your goals, and guide you through the various programs we offer. If youchoose, you may also complete the program order forms and fax it to 1.954.926.1993.

Step 2:

Once you have chosen a program designed to deliver your specific results, Optimal Healthwill set up your account and ask you a series of qualifying questions to complete yourconfidential medical history form. A process that usually takes no more than 15minutes!

Step 3:

Within 48 hours of processing your information we will schedule a comprehensivephysical examination and procure a blood specimen through our nationwide network oflabs and medical affiliates. If preferred, this can be arranged to be done in the privacyof your own home or office. The results will be analyzed and sent directly to the OptimalHealth medical center.

Step 4:

Based on the results of the examination, lab-work and medical history, one of OptimalHealth’s affiliate physicians will write your necessary prescriptions for your supplies, andoffer any qualified advice.

Step 5:

That same day, your program supplies will be shipped via FedEx directly to you from oneof our US- based, associate pharmacies. You will soon begin your physician-supervisedHormone Replacement Program.

It is that easy! All of our programs are designed to offer you a quick, safe and effectiveway to self-administer a comprehensive anti-aging program. You are on your way to betterhealth, energy and performance with Optimal Health. Optimize your life!

How do I get started?

For additional information please contact Optimal Health at

1-877-224-3633www.optimalhealthmd.com

Optimize your l i fe. ™

[ ]7Optimal Health & Rejuvenation Center, LLC © 2007

HGHHUMAN GROWTHHORMONE

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Optimal Health offers physician prescribed and medically supervised Human Growth Hormone (HGH)replacement programs helping patients enter a cost effective, comprehensive age management andphysical development program.

HGH is one of several endocrine hormones such as estrogen, testosterone, melatonin and DHEA thatdecline in production as we age. While many of these hormones can be replaced to deter some of theeffects of aging, HGH goes far beyond suspending these effects. Not only does HGH retard biological agingbut it significantly reverses the aging process. Researchers have proven that HGH therapy can reverse theeffects of aging by as much as 20 years with less than one year of treatment. The benefits of HGH are seenmore and more as new studies manifest its many rewards. HGH Replacement Therapy is the key torejuvenation and added years of vitality to your life.

Hormones can be thought of as "messengers" that are produced by the endocrine glands which are sent allover the body to stimulate specified activities. For example, growth, digestion, reproduction, and sexualfunctions.

As its name suggests, HGH is a hormone that makes humans grow. HGH is a complex protein moleculemade up of 191 amino acids, which is secreted in pulses by the pituitary gland. These pulses vary between10 and 30 per day and can be strengthened by exercise. For years, doctors could only prescribe HGH forchildren who needed a growth boost; now HGH is prescribed to adults since it is integral for functions like:tissue repair, healing, muscle growth, bone strength, brain function, physical and mental health, andmetabolism.

HGH is produced at a rate that peaks during adolescence, at time when normal growth is accelerated,however, the production of HGH decreases with age. Humans normally produce about 500 micrograms(mcg) of HGH daily at age 20. By age 80, the daily production falls to 60 mcg (or less).

Somatropin is the man-made version of HGH. Each manufacturer of somatropin assigns its own brandname, such as Genotropin, Humatrope, Norditropin, Saizen, and Serostim. They are available only byprescription and administered by subcutaneous injection.

Once secreted by the pituitary gland, circulating levels of HGH stimulate production of Insulin-like GrowthFactor 1 (IGF-1) from the liver. You can think of HGH as the hormone that gets the ball rolling, but IGF-1, sometimes called Somatomedin-C, does most of the work. It is the IGF-1 that stimulates cells to divide,which causes growth. The amount of IGF-1 tends to mirror the amount of HGH that is produced byhumans and because blood levels of IGF-1 are more stable, labs usually test for IGF-1 levels to read theHGH levels.

For most people the pituitary gland produces sufficient HGH to retain a youthful appearance until age 35or so. Then, somewhere between age 40 and 50, the body's ability to produce HGH declines to the pointwhere the effects of aging are accelerated and begin to show. Simply put, HGH keeps humans young andattractive.

Optimal Health offers HGH replacement therapy in the form of medically- supervised HGH programs thatare designed to safely replenish and replace your body's own production of HGH. Whether your goals are anti-aging or physical development, Optimal Health has a cost-effective and comprehensive HGH program thatwill deliver the results you want.

INTRODUCTION TO HUMAN GROWTH HORMONE


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ANTI-AGING HGH BENEFITS

Signs of aging and hormone decline

- THINNING SKIN AND INCREASED WRINKLING

- DECREASED ENERGY AND STAMINA

- EXCESS BODY FAT

- LACK OF SEX DRIVE AND DESIRE

- LOSS OF MEMORY & FOCUS

- DECREASED KIDNEY FUNCTION

- HIGHER LDL CHOLESTEROL LEVELS

- WEAKENING HEART ND CIRCULATION

- HAIR LOSS AND DISCOLORATION

- INCREASED ANXIETY AND STRESS

- DIMINISHED BONE DENSITY

- REDUCTION IN THE REJUVENATION PROCESS

- GENERAL FATIGUE

Benefits of HGH replacement therapy

+ ENHANCED SEXUAL PERFORMANCE

+ IMPROVED EXERCISE CAPACITY

+ IMPROVED QUALITY OF DEEP SLEEP

+ BOOST IN ENERGY LEVELS

+ INCREASED LEAN BODY MASS

+ STRENGTHENED IMMUNE SYSTEM

+ SHARPER MEMORY AND CONCENTRATION

+ STRONGER BONES

+ REDUCTION IN CHRONIC FATIGUE

+ REDUCTION IN BODY FAT

+ NORMALIZING OF BLOOD PRESSURE

+ INCREASED HDL (GOOD CHOLESTEROL)

+ DECREASED LDL (BAD CHOLESTEROL)

+ ENHANCED FEELING OF WELL BEING

+ TIGHTER, MORE HYDRATED ANDSMOOTHER SKIN

+ AND MANY OTHER ANTI-AGING AND PERFORMANCE ENHANCING BENEFITS

––––– ++++++

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–++++ + +

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HGH - Our hormone system is best understood if you think of it as a cascade with the brain at the topfollowed by the pituitary gland, then the target organs,e.g. ovaries, thyroid, testicles; and finally physical andmental functions e.g., skin thickness, menstrualperiods, sex characteristics, aggression, hairdistribution, etc. Simply put, Human Growth Hormone(HGH) keeps humans young. For most people thepituitary gland produces sufficient HGH to retain ayouthful appearance until age 35 or so. Then,somewhere between age 40 and 50, the body's abilityto produce HGH declines and the signs of agingbecome more apparent.

Figure 1.

Brain - The hypothalamus is part of the brain and iswhere hormone release originates, starting off thecascade by secreting "releasing hormones" whichactivate the pituitary glands.

Pituitary -The pituitary gland is known as our "mastergland." It sits at the base of our brain andcommunicates directly with the hypothalamus byspecial nerves and blood vessels. “Releasinghormones” travel from the hypothalamus to thepituitary and stimulate the formation and release ofpituitary hormones into our circulatory system. Thepituitary hormones exert their effects on many of ourorgans, such as the thyroid, adrenal glands, testicles,ovaries, and breasts.

There are five basic pituitary hormones:

• Growth Hormone (GH) • Adrenocorticotropic Hormone (ACTH) • Thyroid stimulating Hormone (TSH) • Follicle stimulating Hormone (FSH) • Luteinizing Hormone (LH)

The pituitary hormones are released into the generalcirculation and have effects on specific target organs,which then release hormones of their own. Thus, thepituitary hormones act like traffic controllers, theysurvey the scene, determine what is needed, and tell theorgans when to release their hormones.

DYNAMICS OF HGH REPLACEMENT THERAPY

HGH - Human Growth Hormone decline (ng/ml)

AGE

HG

H O

ptim

al r

ange

(ng

/ml)

1205

870

950

850

1025

1025

1010

1010

10 20 4030 50 60 8070

HGH decline: general approximations Age:

HGHIGF-1 ng/dl

16-24 25-39 40-54 55-60 60-70 70-80

182-780 114-492 90-360 71-290 — —

BRAIN

GHFSHLHLHTSH

IGFESTROGEN

PROGESTERONE

TESTOSTERONE

HYDROCORTISONE

ADRENALGLANDS

TESTICLES OVARIES LIVER THYROID

PITUITARY

HYPOTHALAMUS HGHRELEASING FACTORS

Figure 2.


[ ] Optimal Health & Rejuvenation Center, LLC ©2006 12

BENEFITS VS. RISKS

HGH replacement therapy raises IGF-1 levels in the blood. It is the higher levels of IGF-1 that mediate all theeffects attributed to HGH. Most studies about the use of HGH in adults and children fail to show any cancerrelated risks associated with the use of HGH or higher levels of IGF-1. A review article published in the NewEngland Journal of Medicine on October 14, 1999, authored by Mary Lee Vance, M.D. and Nellie Mauras, M.D.,concluded that there is "at present no evidence that Growth Hormone modulation affects the risk of cancer". Allpatients should be aware, however, that there are other reports that do indicate that there may be a risk. In 1998,two published studies claimed a higher incidence of prostate cancer among men who had higher IGF-1 levelsyears before the onset of the cancer. However, a number of experts agree that these studies are inconclusive andtheir methods may be flawed. Problems cited within these studies included: the method of statistical analysis,the interval between the blood sampling and the onset of cancer and the absence of any IGF-1 measurement atthe time of cancer diagnosis. Several other studies show no difference in IGF-1 levels between normal healthymen and those with prostate cancer at the time of diagnosis and beyond.

More recently, some studies point to a higher incidence of breast cancer in pre-menopausal women (but not postmenopausal), who had higher IGF-1 levels one to five years prior to the onset of breast cancer. In this study, theblood specimens were also drawn prior to diagnosis and were not analyzed for several years, making theseconclusions somewhat suspect and inconclusive.

Although the majority of studies overwhelmingly point toward the safety of HGH, there is, as in virtually any areaof medical science, some conflicting data among studies that may confuse the issue. This is true because of thecomplex nature of the human body and its physiology -- and the truism that medicine is not an exact science. Aswith any aspect of medical therapeutics, each of us must evaluate the information that is available, along withour needs and desires and measure these against any potential risk. Your Optimal Health team can help youunderstand and evaluate all the information available. Obviously we feel that for most patients the benefit ofHGH therapy far outweighs the risk. Only you however, can make the final decision.

To put it into context, similar controversy has surrounded the use of estrogen in post-menopausal women for thepast 30 years. We are now aware that certain studies have shown that estrogen replacement in women mayincrease the risk of breast and endometrial cancer along with other risk factors. However, because of estrogen'sproven protective effects against many other diseases (alzheimer's disease, heart disease, osteoporosis and coloncancer), the overall mortality is lower in women who take estrogen than it is in those who do not. It will be sometime before there is as much data on HGH as there is on estrogen, yet we are convinced that for most peoplewho have lower IGF-1 levels, the benefits of HGH replacement therapy outweigh the risks.

[ ]Optimal Health & Rejuvenation Center, LLC © 2007 13

There are many things one can do to "staying young." Being born with good genes, eating healthy foods,exercising regularly, watching your weight, avoiding stress, and getting enough quality sleep. Good habitswe must all practice, yet these practices in fact, only delay and postpone the signs, symptoms and problemsassociated with aging.

A medically supervised HGH program has many benefits that can improve life on many levels. All of thechoices that you already have about healthy living are still true and should be practiced, whether you arestarting HGH therapy or not. If you are serious about an anti-aging program, remember all good programsshould consist of discipline and commitment in five major areas: HGH replacement, proper diet, nutrition,exercise, and restful sleep.

1. HGH REPLACEMENT

2. PROPER DIET

3. NUTRITION

4. EXERCISE

5. SLEEP

For years, researchers have hunted for a more dramatic way to staying young. Now, after centuries ofseeking the "Fountain of Youth" it appears that medical science has achieved the first major breakthrough,Human Growth Hormone therapy.

The first major study showing the promise of HGH therapy was published in the New England Journal ofMedicine (Rudman; 323:1-6 1990). This study divided 21 men (between the ages of 60 and 80) with IGF-1 levels less than 350 IU per liter into two groups: 12 test subjects and 9 control subjects.

A 6-month period of data collection was followed by a 6-month period in which the test subjects receivedHGH injections. The results were promising: increases in lean muscle mass, decreases in adipose fat tissue,and increases in vertebral bone height. All test subjects had measurable increases in HGH levels, asmeasured by IGF-1 blood values.

The control subject group on the other hand, had none of these results. The effects of six months of humangrowth hormone on body mass and adipose-tissue mass were equivalent in magnitude to the changes incurredduring 10 to 20 years of aging.

For a complete background on recent and past HGH studies and information on HGH therapy in general,we suggest the book entitled “Grow Young With HGH” by Dr. Ronald Klatz (ISBN 0-06-098434-1).

STAYING YOUNG WITH HGH

[ ] Optimal Health & Rejuvenation Center, LLC © 20071

> Begin with small doses - like many hormones,HGH is potent and effective. More is not better! Ifyou are just starting HGH replacement therapy,begin with small doses in the range of 0.1 to 0.8 mgper day. Remember that the goal of HGHreplacement therapy is to restore your HGHproduction level to normal to upper normal ranges---not to exceed normal production.

> Morning injections - Your own production of HGHoccurs mostly at night, during periods of deep sleep.By injecting HGH at bedtime, you have the potentialof discouraging your normal HGH production. So, itis better to inject in the morning. Also, manyphysicians recommend giving your body 1 to 2 "daysoff" per week.

> Watch for adverse side effects - Almost alladverse effects of HGH (water retention, soremuscles, Carpal Tunnel Syndrome) are related todoses that are too high. If you are retaining water,ask your Counselor and/or Physician at OptimalHealth about correcting your dosage. Prolongedoverproduction of HGH can cause serious sideeffects. This can occur in adults who have ahormonal disorder called acromegaly. This disorderis characterized by abnormal growth of the handsand feet. Soft tissue swelling of the hands and feetis often an early symptom, with patients noticinga change in ring or shoe size. If you notice any signsassociated with acromegaly, consult your OptimalHealth Counselor and/or Physician.

> ExerciseIf you do not have an exercise program, you shouldstart one. It does not require membership at a gym.Find a program that fits your lifestyle---walking,swimming, sports---anything that provides areasonable workout several times a week. Studieshave shown that HGH replacement therapy is moreeffective for people who exercise regularly.

> NutritionContinue with a good nutrition supplement programthat includes a good quality multi-vitamin andadditional vitamin supplements containing vitaminsA, C and E along with mineral supplementation.

> SleepSleep is important to good health and it appearsthat several anti-aging hormones, including HGH,are produced at higher levels during sleep thanduring waking hours. On average, 8 hours of sleep issufficient rest for our bodies.

> Proper dietThe daily intake of high glucose carbohydrates, willretard the efforts you are putting into your anti-aging program. You must keep processed foods to anabsolute minimum. Focus on diets containing plentyof vegetables, fruits and plenty of water. Buying abook that gives the glucose ratings of various foodswill help you avoid a high glucose intake.

> Watch your weightHGH replacement therapy is not a weight lossprogram. While it does tend to build lean muscle andreduce fat, many users also find increased appetites.

> Skin and sunWhen you are in the sun, use sun protection. Alsouse a good moisturizer morning and night to helpbalance out and maintain your skin.

> Don't smokeIf you have started HGH replacement therapy tolook and feel better, smoking will only burden theprocess. Among other things, smoking makes yourskin look older.

> WaterDrink plenty of water---every day! A hydrated bodyfunctions better and aids good health.

HEALTHY LIVING AND HGH

Important issues to consider with a HGH replacement therapy program.

TESTOSTERONE

REPLACEMENT

THERAPY

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Testosterone is the androgenic hormone primarilyresponsible for normal growth and development ofmale sex and reproductive organs, including the penis,testicles, scrotum, prostate, and seminal vesicle. Itfacilitates the development of secondary male sexcharacteristics such as musculature, bone mass, fatdistribution, hair patterns, laryngeal enlargement, andvocal chord thickening. Additionally, normal testosteronelevels maintain energy levels, healthy mood, fertility, andsexual desire.

The testes produce testosterone regulated by a complexchain of signals that begins in the brain. This chain iscalled the hypothalamic-pituitary-gonadal axis. Thehypothalamus secretes gonadotropin-releasinghormone (GnRH) to the pituitary gland in carefullytimed pulses (bursts), which triggers the secretion ofthe leutenizing hormone (LH) from the pituitary gland.Leutenizing hormones thus stimulate the Leydig cellsof the testes to produce testosterone. Normally, thetestes produce 4–7 milligrams (mg) of testosteronedaily.

Testosterone production increases rapidly at the onsetof puberty and starts to decrease thereafter. Itdecreases rapidly after age 40 (from 20% to 70% ofpeak level by age 70). Approximately 50 million men inthe United States experience testosterone deficiencyand approximately 700,000 receive treatment.

As men age, the decline in male sex hormones, calledandrogens, results in decreased muscular strength,decline in energy, decreased libido and an increasedrisk of erectile dysfunction resulting in poor sexualperformance.

Testosterone production declines naturally with age.Testosterone deficiency (TD) may result from diseaseor damage to the hypothalamus, pituitary gland, or testicles which inhibits hormone secretion andtestosterone production, known as hypogonadism.Depending on age, insufficient testosterone productioncan lead to abnormalities in muscle and bonedevelopment, underdeveloped genitalia, and diminishedvirility.

For men with a low level of free testosterone in theblood, testosterone or other Hormone ReplacementTherapy (HRT) can be considered. HRT can help menwith low testosterone levels, increase their libido andsexual arousal. Testosterone replacement also canimprove muscle strength and bone mineral density inmen and women with low levels of testosterone.

Androgens such as testosterone, also promote anoverall decrease in fat, an increase in muscle strengthand lean body mass. Testosterone replacement therapyhas been shown to lift mood and decrease anxiety. Itmay enhance orientation and memory and it may alsohave antidepressant effects.

Whether your goals are anti-aging or physicaldevelopment, Optimal Health has a cost-effective andcomprehensive testosterone replacement therapyprogram designed to get the results you want.

By contacting us, you have taken the first step towardbetter health, increased energy and improved sexuality.Optimal Health offers many testosterone programsthat are designed to safely replenish and replace yourbody's own production of testosterone.

INTRODUCTION TO TESTOSTERONE THERAPY

Testosterone decline (general approximations): Age:

Testosterone: ng/dl

20-30 30-40 40-50 50-60 60-70 70-80

280-1205 350-1010 255-1025 255-950 120-870 38-850

[ ]17

Figure 3.

TESTOSTERONE DEFICIENCIES AND BENEFITS

Testosterone deficiency signs

- LOW ENERGY AND STAMINA

- LACK OF SEX DRIVE AND DESIRE

- LOSS OF MEMORY & FOCUS

- MUSCLE WEAKNESS

- HIGH LDL CHOLESTEROL LEVELS

- MOOD DISORDERS

- DEPRESSION

- HAIR LOSS

Testosterone replacement benefits

+ BUILDS LEAN MUSCLE

+ IMPROVES MEMORY

+ IMPROVES MOOD

+ IMPROVES ATHLETIC PERFORMANCE

+ ENHANCES SEX DRIVE

+ IMPROVES SEXUAL PERFORMANCE

+ LOWERS LDL CHOLESTEROL

+ INCREASES ENERGY

+ PROTECTS AGAINST HEART DISEASE

––––– ++++++

–––

–++++ + +

[ ]18 Optimal Health & Rejuvenation Center, LLC © 2007

[ ]1-ContinuedOptimal Health & Rejuvenation Center, LLC © 2007

Types and Causes Hypogonadsim is classified by the location of its cause along the hypothalamic-pituitary-gonadal axis:

• Primary, disruption in the testicles

• Secondary, disruption in the pituitary

• Tertiary, disruption in the hypothalamus. Disease, injury, surgery, and drug side effects can causehypogonadism and testosterone deficiency. Hypogonadism is congenital or acquired, depending on thenature of the underlying condition.

Congenital causes include the following:

• Anorchia (vanishing testes syndrome; causing primary hypogonadism)

• Cryptorchidism (failure of testicles to descend into scrotum; causing primary hypogonadism)

• Hormonal deficiency (e.g., deficiency of leutenizing hormone (LH) releasing hormone; causingsecondary or tertiary hypogonadism)

• Kallmann Syndrome (insufficient hypothalamic GnRH production; causing tertiary hypogonadism)

• Klinefelter Syndrome (underdeveloped testicles; causing primary hypogonadism

Acquired causes include the following:

• Chemotherapy

• Damage procured during surgery to the pituitary gland, hypothalamus, or testes

• Glandular malformation

• Head trauma (affecting the hypothalamus)

• Infection (e.g., meningitis, syphilis, mumps)

• Isolated LH deficiency (e.g., Fertile Eunuch Syndrome)

• Radiation

• Testicular trauma

• Tumors (of the pituitary gland, hypothalamus, or testicles)

TESTOSTERONE DEFICIENCY

[ ] Optimal Health & Rejuvenation Center, LLC © 200720

Signs and Symptoms Signs depend on the age of onset and the duration of hormonal deficiency. Congenital hypogonadism isgenerally characterized by underdeveloped genitalia (testes that do not descend into the scrotum) and,occasionally, undeterminable genitalia. The develop-ment of hypogonadism near puberty can result ingynecomastia (enlargement of breast tissue), sparse or absent pubic and body hair, an underdevelopedpenis, testes, and muscle. Adult men may experience diminished libido, erectile dysfunction, muscleweakness, loss of body hair, depression, and other mood disorders.

ComplicationsTestosterone deficiency has been linked to muscle weakness and osteoporosis. Some studies show, proximaland distal muscle weakness detected in 68% of men with primary or secondary hypogonadism. Spinal,trabecular, and radial cortical bone density may also be significantly reduced in testosterone-deficient men.30 % of men with spinal osteoporosis have long-standing testosterone deficiency, and one-third of thesetestosterone-deficient men have subnormal bone density that puts them at risk for fractures and/or injury.

DiagnosisSerum and blood testing is done to determine the availability of testosterone and levels of LH and GnRHin the body. Men with low testosterone, in whom normal or high gonadotropin levels are found, typicallyhave primary hypogonadism; which may stem from a problem in the testicles. Secondary and tertiary types,caused by problems of the hypothalamus or pituitary gland, often result in low testosterone and lowgonadotropin levels.

Other tests involve injecting GnRH or clomiphene citrate (an estrogen) to stimulate a diagnostic responsewithin the hypothalamic-pituitary gonadal axis. Rarely, is there a need for a testicular biopsy, usually onlyin cases where sperm is absent from ejaculate despite normal testicle development is it necessary. A biopsy,which involves using a needle to collect a sample of testicular tissue, may detect a malfunction in spermproduction.

TreatmentTreatment involves hormone replacement therapy. The method of delivery is determined by age andduration of deficiency. Optimal Health offers many testosterone replacement therapy programs, designed todeliver maximum results in the safest way possible.

Who qualifies for testosterone therapy programs.Treatment for adults is aimed at maintaining secondary sex characteristics, improving energy, strength,mood, and feelings of well-being, and preventing bone degeneration. Modes of delivery include transdermal(gel), injection and oral forms of testosterone.

Transdermal delivery (absorbed through the skin) is used to administer therapeutic agents for hormonereplacement.

Transdermal replacement therapy with a gel or cream is becoming the most common method of treatmentfor testosterone deficiency in adults. It establishes and maintains adequate serum levels without causingsignificant side effects. The most common side effects associated with transdermal testosterone therapymay include itching, discomfort, and irritation at the site of application. Some men may experience fluidretention, acne, and temporary gynecomastia. If necessary, Optimal Health can prescribe medications thathelp prevent these side effects.

This method delivers testosterone for 24 hours when used properly. The gel must be allowed to dry on theskin before contact with clothing and must be applied at least 6 hours before showering or swimming. Thegel should not be applied directly to the genitals.

TESTOSTERONE CONDITIONS & TREATMENT

[ ]

Kallmann Syndrome in adults may be treated with human chorionic gonadotropin, (HCG) which can curecryptorchidism and infertility. Optimal Health has programs that include HCG and can answer any of yourquestions.

Intramuscular (IM) injection is used less frequently because it is associated with erratic testosteronelevels. Levels that shift abruptly between doses may cause fluctuating moods, disrupt energy levels, andinterrupt your libido. Even as such, many athletes and sports people favor IM injections because of thequick results and concentrated method. Optimal Health has programs that include the most popular andsafest forms of injectable testosterone such as Nandrolone Decanoate, Cypionate and Propionate.

Possible side effects The goal of testosterone replacement therapy is to achieve normal to optimal levels of testosterone. Formost patients, testosterone replacement therapy is safe.

Possible side effects, however, include water retention, male pattern baldness, gynecomastia (enlargedbreasts). The oral forms are also associated with some liver problems and the use of large doses oftestosterone (in bodybuilding, for example) increases the risks of these side effects.

Decreased normal testosterone production, prolonged or excessive testosterone therapy prompts thepituitary gland to stop producing the hormone gonadotropin. This, in turn, suppresses normal testosteroneand sperm production, accompanied by shrinkage of the testicles and frequent or continuing (andsometimes painful) erections. Because of this, testosterone replacement therapy is usually prescribed incycles. After a 2- or 3-month period, the patient takes a different drug (such as HCG) that stimulates thetesticles to begin production again.

Remember, the Optimal Health team will give qualified guidance through the various programs availableand individually counsel each patient through the expected benefits and any potential risks.

21Optimal Health & Rejuvenation Center, LLC © 2007

[ ]22

TESTOSTERONE

Testosterone Cypionate: Long acting oil-based injectable, which will keeptestosterone levels sufficiently elevated forapproximately two weeks. It is said to produce aslightly higher level of water retention, and slowingdown the release of testosterone therefore, causing lessproduction of estrogen build-up. However, since thetestosterone is high in estrogen conversion, it can causegynecomastia, this is why an accompanying drug likeNolvadex is added. Although active in the body for amuch longer time period, Cypionate is injected on aweekly basis.

Testosterone Propionate: Oil-based injectable containing ester which slows downthe release for a few days. The Propionate is muchfaster acting and requires a much more frequent dosingschedule that can cause irritation at the site ofinjection. At the same time the buildup of estrogen andDHT will be pronounced, increasing the risk ofgynecomastia. Users therefore need to add an anti-estrogen such as Nolvadex to counteract thisoccurrence. Propionate is a powerful mass-buildingdrug, capable of producing rapid gains in size andstrength.

Nandrolone - Decanoate (Deca):Extremely long acting compound, with a slow releasetime of up to three or four weeks. It exhibits muchweaker androgenic properties than testosterone and isless likely to cause unwanted androgenic side effects.This can also show an extremely lower tendency forestrogen conversion, making water retention a non-issue. Deca has shown not only to be effective at safelybringing up the lean body weight, but is beneficial tothe immune system and works to lubricate the joints.Deca is not known as a "fast" builder. The slow onsetand its mild properties make this more suited for cycleswith of a longer duration. With a cycle lasting 8 to 12weeks, one can expect to elicit a slow even gain ofquality mass.

Testosterone Gel: A clear, colorless, alcohol based gel that gets applied once daily to the inner groin (being careful not to applydirectly to genitals). Upon application, the gel drieswithin a few minutes and the skin absorbs thetestosterone. This serves as a reservoir for the hormone,which slowly enters the bloodstream. Normaltestosterone levels are usually achieved soon after theapplication. One can experience a significant increasein libido (sex drive) an increase in lean body mass,reduction of fatigue, increased bone density, improvedenergy levels, and muscle strength and endurance.

TESTOSTERONE PROGRAMS AVAILABLE

Testosterone - Cypionate Injectable

0

10

20

30

40

50

0 5 10 15

DAY

(ng/

ml)

2520

Testosterone - Propionte Injectable

DAY

(ng/

ml)

0

5

10

15

1 2 43

Testosterone - Nandrolone Decanoate

0

23

1

4

5

6

8

7

1 53 7 9 11 13 16

DAY

(ng/

ml)

Testosterone - Gel

0

23

1

4

5

6

8

7

1 105 15 20 25 30 35

DAY

(ng/

ml)

Figure 4.1

Figure 4.2

Figure 4.3

Figure 4.4


ESTROGEN BLOCKERS

Arimedex (Anastrozole):A non-steroidal agent, Arimidex is the aromataseinhibitor of choice. Especially appropriate when usingsubstantial amounts of aromatizing steroids or whenone is prone to gynecomastia while using moderateamounts of such steroids. Arimidex can achieve a highdegree of estrogen blockage. However, it is possible toreduce estrogen too much with Arimidex---for thisreason blood tests, or the less preferred salivary tests,should be done after the first week of use. This willdetermine if the dosing is correct. Arimidex's mechanismof action is in blocking conversion of aromatizablesteroids to estrogen.

Clomid ( Clomiphene Citrate):Not an anabolic steroid, but a synthetic estrogen withboth agonist/antagonist properties, and is very similarto Nolvadex. It is used to block negative feedback ofestrogens which can cause gynecomastia and enhances therelease of LH and FSH causing natural testosteroneproduction to increase. This is most beneficial at theconclusion of a testosterone cycle. If testosterone levelsare not brought back to normal, a dramatic loss in sizeand strength can occur. Dosages range from 50-100mgdaily over a four to six week period to bring testos-terone production back to normal levels.

Nolvadex (Tamoxifen Citrate): A non-steroidal agent that demonstrates potentantiestrogenic properties. This drug also shows theability to increase production of FSH and LH in themale body. This is accomplished by blocking negativefeedback inhibition caused by estrogen which can causegynecomastia. Since a higher release of LH canstimulate the Leydig’s cells in the testes to producemore testosterone, Nolvadex can have a positive impacton one’s serum testosterone level and help restore abalance in hormone levels. It can also increase therigidity and definition in the muscles. Nolvadex shouldbe taken on the third week of a testosterone cycle untilthe point when natural testosterone levels are wellunder control. Dosages are typically in the range of 10to 30mg daily.

Teslac (Testalactone):Also an estrogen blocker, would be used with HGHinstead of Nolvadex or Chlomid, which can suppressthe effects of HGH. Teslac blocks negative feedbackcaused by estrogen and has the ability to increaseproduction of FSH & LH. This stimulates the leydigscell in the testes to produce more of your own naturaltestosterone. Also helps to harden and define musclesas well as help restore a balance in hormone levels.

LH HORMONE RELEASER

Novarel/HCG (Human Chorionic Gonadotropin):Used to stimulate the production of endogenoustestosterone. It has the ability to mimic the LH, apituitary hormone that stimulates the testes tomanufacture testosterone. The excessive stimulationcan likewise cause the testicles to rapidly return totheir normal size and level of activity. Dosages rangefrom 1000- 2000mg for a duration usually no longerthan 2 or 3 weeks. A combination of HCG andNolvadex appears to be very synergistic, HCG providingan immediate effect on the testes (shocking them outof inactivity) while the antiestrogenic helps to blockinhibition of gynecomastia.

TESTOSTERONE ANCILLARY SUPPLEMENTS

Sample Ancillary Supplement Cycle

STROGEN BLOCKERNolvadexArimidex Clomid Teslac HCG

TESTOSTERONE

1

2

3

456

789

10

11

12

13

14

15

WEEK

Testosterone Estrogen Blocker HCG

Figure 5 is an estimated chart for an average 3 month testosteronecycle. Always consult your physician and follow the recommendedprescribed dosage for each therapy and ancillary supplementprogram combination.

These statements have not been evaluated by the Food and DrugAdministration. Optimal Health & Rejuvenation Center, LLC ©2003

[ ]23

Figure 5


1 Information listed in this document is provided for informational purposes and is not meant to substitute for the advice provided by your ownphysician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease,or prescribing any medication. If you have or suspect that you have a medical problem, promptly contact your health care provider.

2 These statements have not been evaluated by the Food and Drug Administration.



For additional information please contact Optimal Health at

1-877-224-3633www.optimalhealthmd.com

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have made the first step in the right direction towards a vastly improved lifestyle on every level.

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For additional information please contact Optimal Health & Rejuvematin at

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