OpenLIMScOmprehensive sOlutiOn fOr the labOratOry cOmplement

Our missiOn is tO prOvide

a prOfessiOnal and cOmplete

lims fOr the labOratOry

cOmplement

OpenLIMS is the new generation of the Laboratory Information Management System, equipped with open architecture. This LIMS supports several local laboratories, as well as domestic labora-tory chains.

OpenLIMS‘ new generation development began in 2003. The new generation development is based on the great experiences reached during the long period of providing the first generation of LIS (more than 250 installations in the Czech Republic and 100 installations in the Slovak Republic). The works on the first generation of LIS started in 1985, and the first PC-version was installed in 1991.

Two laboratories in the Czech Republic started to work with OpenLIMS in 2005 as pilot projects. From 2006 the system is being released for commercial use in any types of laboratories, and it is capable of managing a wide range of laboratory chains‘ requirements. OpenLIMS supports the following laboratory qualifications: biochemistry, hematology, virology, parasitology, immunology, cytology, bacteriology, microbiology, genetics and pathology.

OpenLIMS is a modern and flexible system, which uses the newest available technologies. OpenLIMS has completely secure access to the data. OpenLIMS is suitable not only for small laboratories with a single workstation, but also for wide

laboratory chains with thousands of workstations. (The biggest installation: 200 workstations with 60 on-line connected analysers).

OpenLIMS enables management of the laboratory chain with joint data sources. OpenLIMS enables communication with all types of analyzers and can easily define the

communication interface with external systems (HIS). OpenLIMS includes many functions for lab assistants, chemists and laboratory managers. OpenLIMS has important operational modules, which are accessible via WWW interface.

WWW interface enables on-line laboratory examination ordering and result-viewing.

Openlims characteristics

analytical capabilities

OpenLIMS supports language modification and enables easy module customization according to any specific legislation.

OpenLIMS has the user friendly interface responding to Microsoft Windows standards. The important work forms are fully configurable and adjustable.

OpenLIMS is directly connected to Stapro HelpDesk application. An experienced team of spe-cialists is ready to help with the laboratory processes optimalization.

OpenLIMS can be constantly monitored from the remote centre in Stapro, Czech Republic. It enables accessibility to the critical parts of the system – database, applications and communica-tion server.

Openlims capabilities Reference range mechanism - It allows the method evaluation in nine intervals differentiated by

various parameters such as sex, age, diagnosis, collection time and other common conditions (i.e. the dependence on the other method result). The reference range has it‘s own history, and it is possible to change it through time. Except for the reference range (physiological range, pathological range), it is possible to define the intervals of the feasible ranges for the numerical values entrance.

Delta Check - Once Delta Check mechanism is configured and activated, every value over the given limits (growth/drop) of test results are checked. The evaluation may be defined by age, sex, diagnosis or other common conditions.

Calculated tests - Common calculated mechanism ena-bles the immediate calcula-tion of the results according to the given results‘ methods and related information.

Inconsistency and automa-tic evaluation - According to pre-defined rules, it is possible to evaluate the methods and their results between them, together with other patient data.

Result history - All previous patient results may be viewed on-line, including all evaluation and text descriptions. The result history may be used when the results have been automatically or manually validated, when the cumulative report has been printed and when Delta Check has been proceeded.

Redundant methods - The redundant examinations are indicated, which can produce reduction in lab costs.

Automatic result approval - According to the reference range evaluation, Delta Check, QC results and other conditions are the automatic result approval provided.

Manual result approval - Manual result approval may be provided in several levels – lab assistant, chemist, doctor, etc.

QC – Internal quality control - The QC archives all samples results manually inserted, or on-line information received from the analyzers. It enables its graphic presentation (Levey-Jen-nings graph, Younden graph) and the comparison of the atest and aberrations. QC includes on-line evaluation of the Westgards rules. The part of QC is also the monitoring of the result averages, where extremes are excluded.

TAT (Total Around Time) - TAT is used for the monitoring and evaluation of the period necessary for the manipulation with all different types of samples.

Definition of calculated test

Result database - The user access policy can be defined separately for some users, and integrated for others.

Access rules - The users‘ definition and allocation to the access rights groups ena-bles to set different access to the modules. It also manages the access to the operational parts or to the methods for each user.

Logging system - Keeps history of all changes in the system and its authors, including the list of cancel-led results/records.

Standard reports - All different kinds of working protocols, main books, name lists, extreme result books, result list, etc.

Report generator - Flexible parametric reports and scripts, colour printing. Automatic report creation on the background

OpenLIMS has a separate communication component. It communicates with analyzers, devices and external subjects (such as HIS, IS for general practitioners, etc.)

The communication component does not depend on the core. It enables communication with analyzers even during possible temporary failure of the connection with OpenLIMS central database.

The communication has been tested on more then 300 analyzers and devices. It supports one-way and two-way communication within the batch mode and also through on-

line mode. It supports POCT analyzers. It provides on-line control transfer to the QC system. It enables transfer of the failure codes from analyzers. Also, there is the possibility upon require-

ment for the automation of repeated or additional examinations according to the measurement results.

It communicates with analyzers through USB, RS 232 or TCP/IP protocol. It communicates with external systems in data standard (Ministry of Health of the Czech

Republic), HL7 interface. The XML format is supported.

Result lists - The format of result lists can be defined by users according to the type of the appli-cants.

Print reports archive - All print reports are archived, if needed with the electronic signature and time stamp.

Electronic distribution - The selected applicants may received the results in electronic format, such as TXT, XML and data standard (Ministry of Health of the Czech Republic). The guaran-teed and secure transfer is provided by product called MISE.

WWW interface for examination requirement input. WWW interface for displaying results.

Submission of requests, identifications and results

security

print recOrds

cOmmunicatiOn

results distributiOn

remOte access

Barcodes - The barcodes are used for the patient identifi-cation, sample identification and for communication with analyzers.

OMR (Optical Mark Reading) - The one-way and two-way automation optical mark reader can be con-nected.

Central entry - All require-ments enter the system in one place and are automati-cally distributed to the ope-rational parts of laboratories.

Sample tracking mechanism - for each sample, a track is kept in the analytical process and in the storage room.

Sequence - Often repeated activities can be predefined and manually or automatically run, when defined conditions are fulfilled. Sequences may be activated on the background as server processes.

Work management - Specifically defined rules help to automatically modify work when defined conditions occur.

Statistics module - Statis-tics reports are generated according to the applicants, type of method and working parts or its groups.

Financial module - It is the separate component, which represents the legislative needs of specific country.

Invoicing - The user is able to make the invoice for the examination (preliminary or final) and also aggregate invoice for the applicant/department.

Daily operation - It enables the creation of reports about all samples in specific parts of the system. Daily statistics - Continuous report about the numbers of samples, daily averages and aberrations. Daily operation control - Continuous control of the daily work, such as duplicity and

misspells.

technOlOgyOpenLIMS uses the newest available development technologies. The system is developed with fol-lowing basic parameters:

component solution in Microsoft.Net and C# technology n-tier architecture database independents national independents (language and application) www interface for the system administration and for the specific components operation

Result report

View of result history

WOrk autOmatiOn

statistics and finance

additiOnal functiOns

system architecture

N-tier architecture represents the strict database separation, application logic and clients presenta-tion tier. The database tier fully respects the rules of SQL databases. It enables to choose the specific database according to the customer need and possibilities.

The operation system on which is the database installed can be UNIX, LINUX or Microsoft servers. For the OpenLIMS client part, Microsoft Windows is used. OpenLIMS works on one PC or on larger networks. The work on large networks has a definite advantage; the database and application server may be separated, and the output is divided according to the operation needs.

The possible OpenLIMS methods of installation: on one workstation with OS Windows-run database, application tier and client tier on server-run database and application tier; workstations run client tier the individual server is used for database and application tier, on workstation-run client tier

According to the needs, the application tier may be installed on more servers/workstations. This enables division of the load among more workstations while several workstations are in use.

For higher accessibility, it is possible to use the cluster solution for the database/application tier.

For the communication with analysers and devices, it is possible to use the individual server. It‘s work is independent to the other parts of the system. This enables communication with analysers, including during possible temporary failure of the main OpenLIMS database.

OpenLIMS is developed as a component system. The basic services are run by the core of the system. Other components are added according to the labo-ratory needs.

The core provides: the access rights and the sys-

tem security the documentation of all

changes made within the sys-tem

the access to the identificati-on register and to the results database

the processes over the register and results database: calculation, validation, print reports, etc. the codes administration and users‘ configuration administration the system versions list and possible upgrade administration

The main components working over the core are: the access to the identification, examination requirements and results input the communication with analyzers and devices the results presentation the print component the statistics including QC and financial components (invoicing, billing)

In OpenLIMS more laboratories can be defined, using the same list of patients applying for the examination. Each laboratory can use its own code lists (methods, texts, etc.) and it‘s work can be divided into independent parts. They may have their own parameters for work with numerical lines of samples and for examination requirements, for results validation, for results distribution, etc.

the verified databases are

micrOsOft sQl v2000

and Oracle v9

system characteristic

System setup

The design of the entrance window for each operational laboratory part may be adjusted according to laboratory needs.

Pentium 4 (or equivalent) PCStandard 512 MB RAM, optimal 1 GB RAM1024x768 VGA17“ color monitor 20 GB Hard DiskRS232 or USB for connectivity with lab analyzers

Depending on the size of the laboratory, it is recommended that a single processor or dual proces-sor server with min. 2GB RAM, equipped with disk array for data storage. For data back-up, tape or DVD RW is used.

The server accessibility will increase, when the two servers in the cluster connected to the disk array would be installed.

Server - UNIX or Linux or Microsoft SQL 2000/2005 Server Database - possibilities: Oracle v9, Microsoft SQL v2000/2005 Application server - Microsoft SQL server 2000/2005 or Windows 2000/XP Workstation - Microsoft Windows 2000/XP and Microsoft .Net Framework Remote administration - RDP (Remote Desktop Protokol) and active Internet

WOrkstatiOn reQuirements

server reQuirements

sOftWare and OperatiOn

systems reQuirements

STAPRO s. r. o.Pernstynske nam. 51 530 02 Pardubice Czech Republic Phone: +420 467 003 111 Fax: +420 467 003 119 E-mail: stapro@stapro.cz

www.stapro.cz

Holder of quality management certificate under ISO 9001:2000 and environmental management certificate under ISO 14001:2004

blOck schema Of n-tier

architecture

Openlims – small labOratOry

Openlims standard

cOnfiguratiOn

Openlims the labOratOry

chain

The List of Connected Analyzers and Devices

Producer TypeBiochemical analyzers

LiasysAbbott AlcyonAbbott Spectrum CCxAbbott Spectrum EPxAbbott AerosetAL Instruments AlixiaAL Instruments Mascott +Baker ENCOREBayer ADVIA 1650Bayer ADVIA 1200Beckmann Synchron CX 4, CX 5Beckmann Synchron CX 7Beckmann LX 20Boehringer Mannheim Hitachi 704Boehringer Mannheim Hitachi 705Boehringer Mannheim Hitachi 717Boehringer Mannheim Hitachi 737Boehringer Mannheim Hitachi 902Boehringer Mannheim Hitachi 911Boehringer Mannheim Hitachi 912Boehringer Mannheim Hitachi 917Boehringer Mannheim ModularCiba Corning Alliance CL -7000Ciba Corning Express +, 550, 560,…Ciba Corning Merck MegaCiba Corning Merck Selectra, Selectra

2,VIVACiba Corning Flexor FDade (Du Pont) Dimension ARDade (Du Pont) Dimension SMS, ESDade (Du Pont) Dimension XL, XPANDDPC Primus CLC 385

Primus PDQEppendorf ELANEppendorf ELAN DUOEppendorf EPOSHoffmann-La Roche Cobas MiraHoffmann-La Roche Cobas Mira S

Hoffmann-La Roche Cobas Mira+Hoffmann-La Roche Cobas Integra 400Hoffmann-La Roche Cobas Integra 700Hoffmann-La Roche Cobas Integra 800Instrument Laboratory ILAB 600Instrument Laboratory ILAB 900Johnson&Johnson Vitros (Ektachem) 250Johnson&Johnson Vitros (Ektachem) 500,

950Johnson&Johnson Vitros EciJohnson&Johnson Vitros (Ektachem) 700,

700XR, 800Orto clinical diagnostic Vitros FusionKone Konelab 30iKone Konelab 60iKone Konelab 20iOlympus AU 400, AU640Olympus AU 560Olympus AU 600Olympus AU 800Olympus AU 2700Technicon AxonTechnicon RA 1000Technicon RA XT

Tosoh G5, Tosoh G7Minerals, ASTRUP, ELFO, ...

Variant IIBioRAD D10

ECA 180Super G, Super GL

AVL AVL 945, 995AVL AVL Compact 1AVL AVL Compact 2AVL AVL Compact 3AVL AVL OMNIAVL AVL 9181AVL AVL OMNI CBiorad VariantCiba Corning Chiron 248Ciba Corning Chiron 348Ciba Corning Chiron 644

Ciba Corning Chiron 850Ciba Corning Chiron 865Eppendorf EBIOEppendorf EFIXEppendorf EFOX 5053, EFIX 5055fotometr - reader BTS 230Instrumentation Lab. EasyLiteInstrumentation Lab. IL 1306Instrumentation Lab. ILAB 900Labsystém FP 901Nova Nova STP 8Nova Nova STAT PROFILE MNova Nova CCX BiomedicalOlympus HiTe320Radiometer ABL 50Radiometer ABL 300Radiometer ABL 330Radiometer ABL 500, 510Radiometer ABL 520Radiometer ABL 625, ABL 620Radiometer ABL 7xx - 725,730,740Instrumentation Lab. GEM Premier 3000Sebia DVS - denzitometrSebia Hyris - denzitometrSebia Preference - denzi-

tometrSebia Foresys. CapillarisBeckman Coulter Paragon cze 2000Instrumentation Lab. Easy Blood GasArkray Osmometr OM6050Bayer Rapidlab 855BD Sedi-15 InstrumentUrine analyzersArkray AUTION JET 4270Arkray AUTION JET 4280Arkray Poket ChemBayer Clintec 50Lachema Laura

Uriscan Pro+Bayer Clintec 500Boehringer Mannheim Miditron M

Urilux SBoehringer Mannheim Miditron JuniorBoehringer Mannheim SupertronDOT LabUReaderLachema UriphanNova NucleusRoche Urisys 2400Roche Urisys 1800Roche Urisys 1100Toa Medical E.CO. Sysmex UF-50, 100

Quidel UrineQuickIQ 200 IRIS

Immunological analyzersprogram LIANAVidas

Abbott ArchitectAbbott AxSYMAbbott Commander PPCAbbott IMxAbbott ADxAbbott LCxBayer CentaurBeckmann AccessBeckmann Unicel DXI 800(=Ac-

cess)Beckmann Array System Beckmann ImmageBeckmann LS 6500Behring Nephelometr BN 100Behring Nephelometr BN2Behring Nephelometr BNABehring OpusBehring BN ProspecBoehringer Mannheim ES 300 (TWIN 300)Boehringer Mannheim Elecsys 1010Boehringer Mannheim Elecsys 2010Ciba Corning ACS 180Diagnostic Products Corp.

DCP Imullite

Diagnostic Products Corp.

DCP Imullite 2000, 2500

Abbott Abbott CellDyn 1800 Abbott Abbott CellDyn 3000 Abbott Abbott CellDyn 3200 Abbott Abbott CellDyn 3500 Abbott Abbott CellDyn 3700 Abbott Abbott CellDyn 4000 Abbott Abbott Sapphire Bayer Advia 60Bayer Advia 120Bayer ADVIA 70Bayer Centrallink WorkcellCiba Corning Chiron 850Coulter Counter M-530 (4)Coulter MAX´M (3-5 p Diff)Coulter HMXCoulter GENS (5p diff)Coulter MD 18, MD II -18Coulter MD 8Coulter Onyx (3-5 p Diff)Coulter S560 (5)Coulter STK-S (5 p Diff)Coulter STKR (5p? diff)Coulter T540 (5)Coulter T660 (6)Coulter T840 (8)Coulter T890 (8)Coulter ACT, ACT 8, ACT 2Coulter ACT 5 diffCoulter LH750Dannam Excell 16Diatron AbbacusHoffmann-La Roche Cobas MicrosHoffmann-La Roche Cobas Minos, STX,

STELHoffmann-La Roche Cobas Vega (5 p Diff)MS Labboratories MS 8 II (diff)MS Labboratories MS 4Nihon Kohden Celltac alfa(MEK6318)Nihon Kohden Celltac F, Celltac ENihon Kohden Celltac F - doubleMUREX Minilyser 2001

Diagnostic Products Corp.

MAXM

Diagnostic Products Corp.

RAS

Dynex Dynatech MRX + SW Dynex technologie Dynex DSXHoffmann-La Roche Cobas CoreHoffmann-La Roche Cobas Core 2Johnson&Johnson AmmerliteKIM soft program KIM-E, T, Q, ...KIM soft program KIM-WRelevation Technologies PHAMAS CapsystemStratec Electronic StratecDiaForin Etimax 3000

AdaltisKryptorLaisonAIA 600AIA 360

Biorad EvolisRADIM(SEAC) BRIORADIM(SEAC) DELTARADIM(SEAC) ALISEI

ABI PRISM 700RIA analyzersBerthold LBIS, LB 2104 (fluores-

cence)Berthold LB 958Hewlett-Packard Cobra IIPharmaTech Wizard 1480RIA LABECO JNG-402,403 with

program RIA LABECOStratec Electronic Stratec RIA with

program TSRINVData submission (differential, ...)Elstasit UPD

EolaBlood picture analyzers

HY CELL + (14-16)Abbott Abbott CellDyn 1200 Abbott Abbott CellDyn 1600Abbott Abbott CellDyn 1700

Serono Serono Baker System 9000

Serono Serono Baker 9018Tecan MiniswiftToa Medical E.CO. Sysmex F-500 (5)Toa Medical E.CO. Sysmex F-800 (8)Toa Medical E.CO. Sysmex K-1000Toa Medical E.CO. Sysmex KX-21 (3 p

Diff)Toa Medical E.CO. Sysmex K-4500Toa Medical E.CO. Sysmex K-800 (8)Toa Medical E.CO. Sysmex NE-1500Toa Medical E.CO. Sysmex SE-9000Toa Medical E.CO. Sysmex SF-3000Toa Medical E.CO. Sysmex XT 1800iToa Medical E.CO. Sysmex XT 2000iToa Medical E.CO. Sysmex XE 2100Melet Schloesing lab. MS 95

AU Micros 60Diamond Diagnostics Pentra 80DiameD AG Diamed, SW MaestroMythic 18

Biosen C-line CoagulometersBehnk Electronik CL 4Behnk Electronik CM 2Behnk Electronik CL 2Behnk Electronik TrombostatBehring Fibrintimer ABehring Fibrintimer BF10Behring BCFInstrumentation Lab. ACL 100-300Instrumentation Lab. ACL FuturaInstrumentation Lab. ACL AdvanceInstrumentation Lab. ACL 9000Instrumentation Lab. ACL 7000Stago ST4Stago CompactToa Medical E.CO. Sysmex CA-500,CA-

540, CA-560Toa Medical E.CO. Sysmex CA-1000Toa Medical E.CO. Sysmex CA-1500

Toa Medical E.CO. Sysmex CA-5000Toa Medical E.CO. Sysmex CA-6000Toa Medical E.CO. SYSMEX CA 7000

AMAXRack Rotor

Organon technika Coag a MateOrganon technika Thrombolyser Compact

XInterpretive programs, LIS connectionALPHAHem-Himas interpretation BiantaHem-Himas interperetation CractesImmunotech WinlianaRoche PSM without result

transferRoche PSM with result transferRoche PSM direct regimeBeckman Remisol