Open Drug Discovery Teams
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Transcript of Open Drug Discovery Teams
Open Drug Discovery Teams
(ODDT)http://slidesha.re/xzGhFH
A New Challenge
Mid January Pistoia Alliance ask for volunteers to present in a Dragon’s Den scenario Feb 8th at the RSC
Ideas that will transform Pharma R&D in 2014 So my natural response was :
“If I am going to take part I want to create something real”
http://pistoiaalliance.org/
http://bit.ly/wImJtH
Could an app transform R&D ?
Tuberculosis Kills 1.6-1.7m/yr (~1 every 8 seconds) equivalent to malaria No new drugs in over 40 yrs Pipeline is thin and weak BMGF & NIH do not coordinate TB efforts, not
mandating open data.
> 7000 rare diseases e.g. Jill Wood started a foundation, raises money, awareness, funds
ground breaking research happening globally.
She is in a race against time – what can we do to translate ideas from bench to patient faster?
How can we help parents and families ?
Inspiration There are many 1000s of diseases and few with cures
Science Online 2012 on open notebooks and data overload
Could we create an app for science like Flipboard?
http://slidesha.re/why7gg
Within about 10 days Alex Clark Created ODDT to present at the Pistoia meeting
Focused on Tuberculosis, Malaria, HIV/AIDS, Huntington’s Disease, Sanfilippo Syndrome, and Green Chemistry as topics in version 1
We did not win the competition but had useful feedback – the need to articulate the value proposition
http://slidesha.re/GzVSPr
The Value Proposition The project is intended to bring together open data in a single aggregated
collection, and then facilitate forming open research teams around this data
Disseminate important information to a highly relevant target audience
Network and discover other researchers with complementary interests, and opportunities to collaborate
Team members will be able to borrow and reuse a growing collection of existing Open data.
The community as a whole can debate, contest or endorse data based on its quality.
The app could also be used as a type of “lab notebook” whereby individual researchers share links (URLs) to content and the app aggregates these.
http://slidesha.re/weDFLg
Latest Layout
9 Panels includes one on ODDT information
Can use multiple Twitter accounts Here is my icon
Stats summary
About App
Tap on a panel and look at Incoming contents
Click here to endorse or disapprove
Click here to follow hyperlink
Incoming is sorted by time of creation
Browse through multiple pages of tweets
Endorse, Disapprove and Comment
Recent contents
Click on image to open it
Recent isfactoids with a vote count of +1 or better
Content
Ranked content
Click on image to open it
Content is currently anything with a votecount of +1 or better, sorted by most popular first
Tap on a link or image
Be able to download content
Look at your own statistics
Exposing rare diseases – creating communities of researchers and sparking
discussion
My tweets on recent analyses and ideas
My Retweets
Coming Soon
Rewards – badges Beta version More ideas that may need funding to cover server
etc - Would you fund us if we posted ODDT on
Kickstarter or Petridish.org or IndieGoGo?? Are there sponsors for specific pages or content?
From idea to appstore in ~2 months Available on appstore since April 12 Future versions will allow user to specify topics Presented at ACS Submitted business plan to ACS GCI
Thank you Alpha testers
Antony J. Williams Hans De Winter Chris Swain Andrew Lang Carlo Yuvienco Paul Reinheimer Michael S. Lajiness Nancy Connell Greta Beekhuis Joe Hupcey III Freundlich, Joel Tanya Parrish Peter Olinga Peter Caduff
ODDTPhoto for San Fillipo Syndrome courtesy of Jill Wood www.jonahsjustbegun.org
More Information Please contact us for further details or suggestions at:
[email protected] and [email protected]
You can learn more about the ODDT app at: http://www.scimobileapps.com/index.php?title=Open_Drug_Discovery_Teams
And frequent blogs at http://www.collabchem.com and http://cheminf20.org/
User guide now available at SlideShare http://slidesha.re/JcDTOsand FigShare http://bit.ly/IjR52V